1 EXHIBIT 21.1 SUBSIDIARIES OF THE REGISTRANT: Glycomed Incorporated 10275 Science Center Drive San Diego, California 92121 Ligand Pharmaceuticals (Canada) Inc. 374 3rd Avenue South Saskatoon, Saskatchawan Canada STKIMS Ligand JVR, Inc. 10275 Science Center Drive San Diego, California 92121 Allergan Ligand Retinoid Therapeutics, Inc. 10275 Science Center Drive San Diego, California 92121 Knight Acquisition Corporation 10275 Science Center Drive San Diego, California 92121