ADOPTION AGREEMENT FOR

                            AUTOMATIC DATA PROCESSING
                     NON-STANDARDIZED 401(K) PROFIT SHARING
                                 PLAN AND TRUST

     The  undersigned  Employer  adopts  the  Automatic  Data  Processing
Non-Standardized  401(k)  Profit  Sharing Plan and Trust for those Employees who
shall  qualify  as  Participants  hereunder,  to  be  known  as  the

A1     Exelixis,  Inc.  401(k)  Plan
       -----------------------------
           (Enter  Plan  Name)

It  shall  be  effective  as  of  the  date specified below. The Employer hereby
selects  the  following  Plan  specifications:

CAUTION:     The failure to properly fill out this Adoption Agreement may result
             in  disqualification  of  the  Plan.

EMPLOYER  INFORMATION


B1          Name  of  Employer  Exelixis,  Inc.
                                ---------------


B2          Address  170  Harbor Way  P.  O.  Box  0511
                     ----------------------------------

                     San  Francisco,         CA            94083-0511
                     -----------------      -----          ----------
                           City             State              Zip

            Telephone   650-837-7000
                       -------------

B3     Employer  Identification  Number  04-3257395
                                         ----------

B4     Date  Business  Commenced  November  15,  1994
                                  -------------------

B5     TYPE  OF  ENTITY

     a. ( ) S Corporation
     b. ( ) Professional Service Corporation
     c. (X) Corporation
     d. ( ) Sole Proprietorship
     e. ( ) Partnership
     f. ( ) Other

     AND,  is  the  Employer  a  member  of
          g.  a  controlled  group?  (X)  Yes  (  )  No
          h.  an  affiliated  service  group?  (  )  Yes  (X)  No


B6     NAME(S)  OF  TRUSTEE(S)

     a. State Street Bank
       --------------------

     b.
       --------------------
     c.
       --------------------
     d.
       --------------------
     e.
       --------------------

B7     TRUSTEES'  ADDRESS

     a. ( ) Use Employer Address

     b. (X) 200 Newport Avenue, Q3N
            ---------------------------
                    Street

            North  Quincy     ,      Massachusetts           02171
            --------------           --------------         -------
                 City                    State                Zip

B8     LOCATION  OF  EMPLOYER'S  PRINCIPAL  OFFICE:

     a. (X) State b. ( ) Commonwealth of c. California and this Plan
                                            ----------
            and  Trust  shall  be  governed  under  the  same.

B9     EMPLOYER  FISCAL  YEAR  means  the  12  consecutive  month  period:

       Commencing  on  a.    January  1      (e.g.,  January  1st)  and
                          ---------------
                           month     day

       ending  on  b.  December  31     .
                      -------------
                      month     day


PLAN  INFORMATION

C1     EFFECTIVE  DATE

          This  Adoption  Agreement  of  the  Automatic  Data  Processing
          Non-Standardized  401(k)
          Profit  Sharing  Plan  and  Trust  shall:

          a.  (  )  establish  a new Plan and Trust effective as of (hereinafter
          called  the  "Effective  Date").

          b.  (X)  constitute  an amendment and restatement in its entirety of a
          previously  established qualified Plan and Trust of the Employer which
          was  effective  February  1,  1998  (hereinafter called the "Effective
                          ------------------
          Date").  Except  as  specifically  provided in the Plan, the effective
          date  of this amendment and restatement is October 1, 2001(For TRA '86
                                                     ---------------
          amendments,  enter  the  first day of the first Plan Year beginning in
          1989).

C2     PLAN  YEAR  means  the  12  consecutive  month  period:

          Commencing  on  a.  January  1  (e.g.,  January  1st)  and
                             -----------

          ending  on  b.  December  31  .
                         -------------

          IS  THERE  A  SHORT  PLAN  YEAR?

          c.  (X)  No
          d.  (  )  Yes,  beginning
                                   -----------
                    and  ending
                               ---------------

C3     ANNIVERSARY  DATE  of  Plan  (Annual  Valuation  Date)

          a.  December  31
              -------------
               month  day

C4     PLAN  NUMBER  assigned  by  the  Employer  (select  one)

          a.  (X)  001  b.  (  )  002  c.  (  )  003  d.  (  )  Other
                                                                      ---------

C5     NAME OF PLAN ADMINISTRATOR (Document provides for the Employer to appoint
       an  Administrator.  If  none  is  named,  the Employer will become the
       Administrator.)

          a.  (X)  Employer  (Use  Employer  Address)

          b.  (  )  Name

          Address  (  )  Use  Employer  Address

                   ------------------------------------------------------------

                   --------------------,     ----------------   ---------------

                         City                     State                Zip

                   Telephone
                            ---------------------------------------------------

                   Administrator's  I.D.  Number
                                                -------------------------------

C6     PLAN'S  AGENT  FOR  SERVICE  OF  LEGAL  PROCESS

          a.  (X)  Employer  (Use  Employer  Address)

          b.  (  )  Name
                        -------------------------------------------------------

                    Address
                           ----------------------------------------------------

                           ----------------------------------------------------



ELIGIBILITY,  VESTING  AND  RETIREMENT  AGE


D1     ELIGIBLE  EMPLOYEES  (Plan  Section  1.15)  shall  mean:

          a.  ( ) all Employees who have satisfied the eligibility requirements.
          b.  (X)  all Employees who have satisfied the eligibility requirements
          except  those  checked  below:

               1.  (  )  Employees  paid  by  commissions  only.
               2.  (  )  Employees  hourly  paid.
               3.  (  )  Employees  paid  by  salary.
               4.  (  )  Employees  whose employment is governed by a collective
               bargaining  agreement  between  the  Employer  and  "employee
               representatives" under which retirement benefits were the subject
               of  good  faith  bargaining. For this purpose, the term "employee
               representatives" does not include any organization more than half
               of  whose  members  are  employees  who  are owners, officers, or
               executives  of  the  Employer.
               5.  (  )  Highly  Compensated  Employees.
               6.  (  )  Employees  who  are non-resident aliens who received no
               earned income (within the meaning of Code Section 911(d)(2)) from
               the  Employer  which  constitutes  income from sources within the
               United  States  (within  the  meaning of Code Section 861(a)(3)).
               7.  (X)  Other  Leased  employee,  temps  or  interns
                        --------------------------------------------

          NOTE:  For  purposes  of this section, the term Employee shall include
          all  Employees  of this Employer and any leased employees deemed to be
          Employees  under  Code  Section  414(n)  or  414(o).

D2     EMPLOYEES  OF  AFFILIATED  EMPLOYERS  (Plan  Section  1.16)

          Employees  of  Affiliated  Employers:

          a.  (X)  will  not  or  N/A
          b.  ( )  will

          be  treated  as  Employees  of  the  Employer  adopting  the  Plan.

          NOTE:  If D2b is elected, each Affiliated Employer should execute this
                 Adoption Agreement as a Participating Employer.


D3     HOURS  OF  SERVICE (Plan Section 1.31) will be determined on the basis of
          the method selected below. Only one method may be selected. The method
          selected  will  be  applied  to  all Employees covered under the Plan.

          a.  (  ) On the basis of actual hours for which an Employee is paid or
          entitled  to  payment.
          b.  ( ) On the basis of days worked. An Employee will be credited with
          ten  (10)  Hours  of  Service if under the Plan such Employee would be
          credited  with  at  least  one  (1)  Hour  of  Service during the day.
          c. ( ) On the basis of weeks worked. An Employee will be credited
          forty-five (45) Hours of Service if under the Plan such Employee would
          be credited with at least one (1) Hour of Service during the week.
          d.  ( ) On the basis of semi-monthly payroll periods. An Employee will
          be  credited  ninety-five (95) Hours of Service if under the Plan such
          Employee  would  be  credited  with  at  least one (1) Hour of Service
          during  the  semi-monthly  payroll  period.
          e. (X) On the basis of months worked. An Employee will be credited one
          hundred  ninety (190) Hours of Service if under the Plan such Employee
          would  be  credited  with  at least one (1) Hour of Service during the
          month.

D4     CONDITIONS  OF  ELIGIBILITY  (Plan  Section  3.1)
       (Check  either  a  OR  b  and  c,  and  if  applicable,  d)

          Any  Eligible  Employee will be eligible to participate in the Plan if
          such Eligible Employee has satisfied the service and age requirements,
          if  any,  specified  below:

          a.  (  )  NO  AGE  OR  SERVICE  REQUIRED.

          b.  (X)  SERVICE  REQUIREMENT.  (may  not  exceed  1  year)

               1.  (  )  None
               2.  (  )  1/2  Year  of  Service
               3.  (  )  1  Year  of  Service
               4.  (X)  Other  immediate
                               -----------

          NOTE: If the Year(s) of Service selected is or includes a fractional
               year,  an Employee will not be required to complete any specified
               number  of Hours of Service to receive credit for such fractional
               year.  If expressed in Months of Service, an Employee will not be
               required  to complete any specified number of Hours of Service in
               a  particular  month.

          c.  (X)  AGE  REQUIREMENT  (may  not  exceed  21)

               1.  (  )  N/A  -  No  Age  Requirement.
               2.  (  )  20  1/2
               3.  (X)   21
               4.  (  )  Other

          d.  (  )  FOR  NEW  PLANS ONLY - Regardless of any of the above age or
          service  requirements,  any  Eligible Employee who was employed on the
          Effective  Date of the Plan shall be eligible to participate hereunder
          and  shall  enter  the  Plan  as  of  such  date.



D5     EFFECTIVE  DATE  OF  PARTICIPATION  (Plan  Section  3.2)
       An  Eligible  Employee  shall  become  a  Participant  as  of:

          a.  (  )  the  first  day  of  the  Plan  Year  in  which  he  met the
          requirements.
          b.  (  )  the  first  day  of  the  Plan  Year  in  which  he  met the
          requirements,  if he met the requirements in the first 6 months of the
          Plan  Year, or as of the first day of the next succeeding Plan Year if
          he  met  the  requirements  in  the  last  6  months of the Plan Year.
          c.  ( ) the earlier of the first day of the seventh month or the first
          day  of  the  Plan  Year coinciding with or next following the date on
          which  he  met  the  requirements.
          d. ( ) the first day of the Plan Year next following the date on which
          he  met  the requirements. (Eligibility must be 1/2 Year of Service or
          less  or  1  1/2 Years of Service or less if 100% immediate vesting is
          selected  and  age  20  1/2  or  less.)
          e.  (  )  the first day of the month coinciding with or next following
          the  date  on  which  he  met  the  requirements.
          f.  (X)  Other: Quarterly, provided that an Employee who has satisfied
                          ---------
          the maximum  age  and  service  requirements  that  are
          permissible  in  Section  D4  above  and  who is otherwise entitled to
          participate, shall commence participation no later than the earlier of
          (a)  6  months after such requirements are satisfied, or (b) the first
          day  of  the  first  Plan  Year after such requirements are satisfied,
          unless  the  Employee separates from service before such participation
          date.


D6     VESTING  OF  PARTICIPANT'S  INTEREST  (Plan  Section  6.4(b))

          The vesting schedule, based on number of Years of Service, shall be as
          follows:

          a.  (  ) 100% upon entering Plan. (Required if eligibility requirement
                   is  greater  than  one  (1)  Year  of  Service.)

          b.  (  )  0-2  years    0%       c.  (  )  0-4  years    0%
                      3  years  100%                   5  years  100%

          d.  (  )  0-1  year     0%       e.  (  )    1  year    25%
                      2  years   20%                   2  years   50%
                      3  years   40%                   3  years   75%
                      4  years   60%                   4  years  100%
                      5  years   80%
                      6  years  100%

          f.  (  )    1  year  20%         g.  (  )  0-2  years    0%
                      2  years  40%                    3  years   20%
                      3  years  60%                    4  years   40%
                      4  years  80%                    5  years   60%
                      5  years  100%                   6  years   80%
                      7  years  100%

          h.  (  ) Other - Must be at least as liberal as either c. or g. above.

                         Years  of  Service  Percentage
                         1                   33  1/3%
                         2                   66  2/3%
                         3                  100%


D7   FOR  AMENDED PLANS (Plan Section 6.4(f)) If the vesting schedule has been
     amended to a less favorable schedule, enter the pre-amended schedule below:

     a.  (X)  Vesting  schedule has not been amended or amended schedule is more
              favorable  in  all  years.

     b.  (  )  Years  of  Service  Percentage
               ------------------  ----------
               ------------------  ----------
               ------------------  ----------
               ------------------  ----------
               ------------------  ----------
               ------------------  ----------




D8   TOP  HEAVY VESTING (Plan Section 6.4(c)) If this Plan becomes a Top Heavy
     Plan,  the following vesting schedule, based on number of Years of Service,
     for  such  Plan Year and each succeeding Plan Year, whether or not the Plan
     is  a  Top Heavy Plan, shall apply and shall be treated as a Plan amendment
     pursuant  to  this  Plan. Once effective, this schedule shall also apply to
     any  contributions  made  prior  to  the effective date of Code Section 416
     and/or  before  the  Plan  became  a  Top  Heavy  Plan.

     a.  (X)  N/A  (D6a,  b,  d,  e  or  f  was  selected)

     b.  (  )  0-1  year  0%              c.  (  )  0-2  years   0%
                 2     years     20%                  3  years 100%
                 3     years     40%
                 4     years     60%
                 5     years     80%
                 6     years    100%

     NOTE:  This  section  does  not  apply  to  the  Account  balances  of  any
          Participant  who  does  not have an Hour of Service after the Plan has
          initially  become  top  heavy.  Such  Participant's  Account  balance
          attributable  to  Employer  contributions  and  Forfeitures  will  be
          determined  without  regard  to  this  section.

D9   VESTING (Plan Section 6.4(h)) In determining Years of Service for vesting
     purposes, Years of Service attributable to the following shall be EXCLUDED:

     a.  (  )  Service  prior to the Effective Date of the Plan     b. (X) N/A.
               or a predecessor plan.
     c.  (  )  Service prior to the time an Employee attained       d. (X) N/A.
               age 18.

D10     PLAN  SHALL  RECOGNIZE  SERVICE  WITH  PREDECESSOR  EMPLOYER

     a.  (X)  No.
     b.  (  ) Yes: Years of Service with ___ shall be recognized for the purpose
              of  this  Plan.

     NOTE:  If  the  predecessor  Employer  maintained this qualified Plan, then
          Years  of  Service  with such predecessor Employer shall be recognized
          pursuant  to  Section  1.74  and  b.  must  be  marked.

D11     NORMAL  RETIREMENT  AGE  ("NRA")  (Plan  Section  1.42)  means:

          a.  (X)  the  date  a  Participant  attains his 65th birthday. (not to
                   exceed  65th)
          b.  (  ) the later of the date a Participant attains his ___ birthday
                   (not  to  exceed  65th)  or  the  c.  __ (not to exceed 5th)
                   anniversary  of  the  first -- day of the Plan Year in which
                   participation  in  the  Plan  commenced.


D12     NORMAL  RETIREMENT  DATE  (Plan  Section  1.43)  shall  commence:

          a.  (X)  as  of  the  Participant's  "NRA."

               OR  (must  select  b.  or  c.  AND  1.  or  2.)

          b.  (  )  as  of  the  first  day  of  the  month
          c.  (  )  as  of  the  Anniversary  Date

               1. ( ) coinciding with or next following the Participant's "NRA."
               2. ( )  nearest  the  Participant's  "NRA."

D13     EARLY  RETIREMENT  DATE  (Plan  Section  1.12)  means  the:

          a.  (X) No  Early  Retirement  provision  provided.
          b.  ( ) date  on  which  a  Participant
          c.  ( ) first day of the month coinciding with or next following the
                  date  on  which  a  Participant
          d.  ( ) Anniversary Date coinciding with or next following the date on
                  which  a  Participant

          AND,  if  b.,  c.  or  d.  was  selected

               1.  (  )  attains  his  ___  birthday  and  has
               2.  (  )  completed  at  least  ___  Years  of  Service.


CONTRIBUTIONS,  ALLOCATIONS  AND  DISTRIBUTIONS


E1 a. COMPENSATION (Plan Section 1.9) with respect to any Participant means:

          1.  (X)  Wages,  tips  and  other  Compensation  on  Form  W-2.
          2.  (  )  Section  3401(a)  wages  (wages  for  withholding purposes).
          3.  (  )  415  safe-harbor  compensation.

          AND  COMPENSATION

          1.  (X)  shall
          2.  (  )  shall  not

          exclude  (even  if includible in gross income) reimbursements or other
          expense  allowances,  fringe  benefits  (cash  or  noncash),  moving
          expenses,  deferred  compensation,  and  welfare  benefits.

     b.   COMPENSATION shall be

          1.  (X)  actually  paid  (must  be  selected  if  Plan  is integrated)
          2.  (  )  accrued

     c.   HOWEVER, FOR NON-INTEGRATED PLANS, Compensation shall exclude (select
          all that apply):

          1.  (X)  N/A.  No  exclusions
          2.  (  )  overtime
          3.  (  )  bonuses
          4.  (  )  commissions
          5.  (  )  other  ___


     d.   FOR  PURPOSES  OF  THIS  SECTION  E1,  Compensation shall be based on:

          1. (X)the  Plan  Year.
          2. ( )the Fiscal Year coinciding with or ending within the Plan Year.
          3. ( )the  Calendar  Year  coinciding with or ending within the Plan
             Year.

     NOTE:  The  Limitation  Year  shall  be  the  same  as  the  year  on which
          Compensation  is  based.

     e.   HOWEVER,  for  an Employee's first year of participation, Compensation
          shall  be  recognized  as  of:

          1.  ( )  the  first  day  of  the  Plan  Year.
          2.  (X)  the  date  the  Participant  entered  the  Plan.

     f.   IN  ADDITION,  COMPENSATION  and  "414(s)  Compensation"
          1(  ).  shall  2.  (X) not include compensation which is not currently
          includible  in  the  Participant's  gross  income  by  reason  of  the
          application  of  Code Sections 125, 402(a)(8), 402(h)(1)(B) or 403(b).


E2   SALARY  REDUCTION  ARRANGEMENT  - ELECTIVE CONTRIBUTION (Plan Section 11.2)
     Each  Employee  may  elect  to  have  his  Compensation  reduced  by:

     a.   (  )  ___%

     b.   (X)  up  to  20%
                       ---
     c.   ( )  from%  to%
     d.   ( ) up to the maximum percentage allowable not to exceed the limits of
          Code  Sections  401(k),  404  and  415.

     AND

     e.   (X)  A  Participant may elect to commence salary reductions as of each
          business  day  (ENTER  AT LEAST ONE DATE OR PERIOD). A Participant may
          modify  the amount of salary reductions as of each business day (ENTER
          AT  LEAST  ONE DATE  OR  PERIOD).

     AND

          Shall  cash bonuses paid within 2 1/2 months after the end of the Plan
          Year  be  subject  to  the  salary  reduction  election?

     f.   (X)  Yes
     g.   (  )  No

E3   FORMULA  FOR  DETERMINING  EMPLOYER'S  MATCHING  CONTRIBUTION (Plan Section
     11.1(b))

     a.   (  )  N/A.  There  shall  be  no  matching  contributions.
     b.   (X) The Employer shall make matching contributions equal to 50_% (e.g.
          50%)  of  the  Participant's  salary  reductions.  Up  to  4%
     c.   (  )  The  Employer  may  make  matching  contributions  equal  to  a
          discretionary  percentage,  to  be  determined by the Employer, of the
          Participant's  salary  reductions.
     d.   ( ) The Employer shall make matching contributions equal to the sum of
          ____%  of the portion of the Participant's salary reduction which does
          not  exceed  ____% of the Participant's Compensation plus ____% of the
          portion  of the Participant's salary reduction which exceeds ____ % of
          the  Participant's  Compensation,  but  does  not  exceed ____% of the
          Participant's  Compensation.
     e.   (  )  The  Employer  shall  make  matching  contributions equal to the
          percentage  determined  under  the  following  schedule:

                 Participant's Total
                  Years of Service          Matching Percentage
                 -------------------        -------------------


FOR PLANS WITH MATCHING CONTRIBUTIONS

f.   (X)  Matching  contributions  g.  (  )  shall  h.  (X) shall not be used in
     satisfying  the  deferral  percentage  tests.  (If  used,  full vesting and
     restrictions  on  withdrawals will apply and the match will be deemed to be
     an  Elective  Contribution).
i.   (  )  Shall a Year of Service be required in order to share in the matching
     contribution?

     With  respect  to  Plan  Years  beginning  after  1989
          1.   (  )  Yes  (Could cause Plan to violate minimum participation and
               coverage  requirements  under  Code  Sections 401(a)(26) and 410)
          2.   (X)  No

     With  respect  to  Plan  Years  beginning  before  1990
          1.  (X)  N/A,  new  Plan,  or  same  as  years  beginning  after  1989
          2.  (  )  Yes
          3.  (  )  No

j.   (X)  In  determining  matching  contributions, only salary reductions up to
     4%of  a  Participant's  Compensation  will  be  matched.  k.  (  )  N/A
   ----
l.   (  ) The matching contribution made on behalf of a Participant for any Plan
     Year  shall  not  exceed  $  ____.  m.  (  X  )  N/A
                                      ------
n.   (X)  Matching  contributions  shall  be  made  on  behalf  of
          1.  (X)   all  Participants.
          2.  ( )   only  Non-Highly  Compensated  Employees.

o.   (  X  )  Notwithstanding anything in the Plan to the contrary, all matching
     contributions  which  relate  to  distributions  of  Excess  Deferred
     Compensation,  Excess  Contributions,  and  Excess  Aggregate Contributions
     shall  be  Forfeited.  (Select  this  option  only  if  it  is applicable.)


E4   WILL  A  DISCRETIONARY  EMPLOYER  CONTRIBUTION  BE  PROVIDED  (OTHER THAN A
     DISCRETIONARY  MATCHING  OR  QUALIFIED  NON-ELECTIVE  CONTRIBUTION)  (Plan
     Section  11.1(c))?

     a.  (  )  No.
     b.   ( ) Yes, the Employer may make a discretionary contribution out of its
          current  or  accumulated  Net  Profit.
     c.   (X)  Yes,  the Employer may make a discretionary contribution which is
          not  limited  to  its  current  or  accumulated  Net  Profit.

     IF  YES  (b.  or  c.  is  selected  above),  the  Employer's  discretionary
     contribution  shall  be  allocated  as  follows:

     d.   (X)  FOR  A  NON-INTEGRATED  PLAN

     The  Employer  discretionary  contribution  for  the  Plan  Year  shall  be
     allocated in the same ratio as each Participant's Compensation bears to the
     total  of  such  Compensation  of  all  Participants.

     e.   (  )  FOR  AN  INTEGRATED  PLAN

     The  Employer  discretionary  contribution  for  the  Plan  Year  shall  be
     allocated  in  accordance  with  Plan  Section  4.3(b)(2)  based  on  a
     Participant's  Compensation  in  excess  of:

          f.  (  )  The  Taxable  Wage  Base.
          g.  (  )  The  greater  of  $10,000  or  20% of the Taxable Wage Base.
          h.  (  )  ____%  of  the  Taxable  Wage  Base.  (See  Note  below)
          i.  (  )  $___.  (see  Note  below)

     NOTE:  The  integration  percentage  of  5.7%  shall  be  reduced  to:

               1.   4.3%  if  h.  or  i. above is more than 20% and less than or
                    equal  to  80%  of  the  Taxable  Wage  Base.
               2.   5.4%  if  h. or i. above is less than 100% and more than 80%
                    of  the  Taxable  Wage  Base.

E5     QUALIFIED  NON-ELECTIVE  CONTRIBUTIONS  (Plan  Section  11.1(d))

     a.   ( ) N/A. There shall be no Qualified Non-Elective Contributions except
          as  provided  in  Sections  11.5(b)  and  11.7(h)
     b.   (  )  The  Employer  shall  make a Qualified Non-Elective Contribution
          equal  to  ___% of the total Compensation of all Participants eligible
          to  share  in  the  allocations.
     c.   (X)  The Employer may make a Qualified Non-Elective Contribution in an
          amount  to  be  determined  by  the  Employer.


E6     FORFEITURES  (Plan  Section  4.3(e))

     a.   Forfeitures  of  contributions other than matching contributions shall
          be

          1.   (X)  added  to  the  Employer's  contribution  under  the  Plan.
          2.   (  )  allocated  to  all  Participants  eligible  to share in the
               allocations  in  the  same  proportion  that  each  Participant's
               Compensation  for  the  year  bears  to  the  Compensation of all
               Participants  for  such  year.

     b.  Forfeitures  of  matching  contributions  shall  be

          1.   ( )  N/A.  No  matching  contributions or match is fully vested.
          2.   (X)  used  to  reduce  the  Employer's  matching  contribution.
          3.   ( )  allocated  to  all  Participants  eligible  to share in the
               allocations in proportion to each such Participant's Compensation
               for  the  year.
          4.   ( )  allocated to all Non-Highly Compensated Employee's eligible
               to  share  in  the  allocations  in  proportion  to  each  such
               Participant's  Compensation  for  the  year.

E7   ALLOCATIONS  TO ACTIVE PARTICIPANTS (Plan Section 4.3) With respect to Plan
     Years  beginning  after  1989,  a  Participant

     a.  (  )  shall  (Plan  may  become  discriminatory)
     b.  (X  )  shall  not

     be  required  to  complete  a  Year  of  Service  in  order to share in any
     Non-Elective Contributions (other than matching contributions) or Qualified
     Non-Elective  Contributions. For Plan Years beginning before 1990, the Plan
     provides that a Participant must complete a Year of Service to share in the
     allocations.


E8   ALLOCATIONS  TO  TERMINATED  PARTICIPANTS  (Plan  Section  4.3(k))  Any
     Participant  who  terminated  employment  during  the  Plan  Year (i.e. not
     actively  employed on the last day of the Plan Year) for reasons other than
     death,  Total  and  Permanent  Disability  or  retirement:

     a.   With  respect  to  Employer  Non-Elective  Contributions  (other  than
          matching),  Qualified  Non-Elective  Contributions,  and  Forfeitures:

          1.  For  Plan  Years  beginning  after  1989,

               i.   ( )  N/A,  Plan  does  not  provide for such contributions.
               ii.  ( ) shall share in the allocations provided such Participant
                    completed  more  than  500  Hours  of  Service.
               iii. ( )  shall  share  in  such  allocations  provided  such
                    Participant  completed  a  Year  of  Service.
               iv.  (X) shall not share in such allocations, regardless of Hours
                    of  Service.

          2.  For  Plan  Years  beginning  before  1990,

               i.   (X) N/A, new Plan, or same as for Plan Years beginning after
                    1989.
               ii.  (  )  shall  share  in  such  allocations  provided  such
                    Participant  completed  a  Year  of  Service.
               iii. ( ) shall not share in such allocations, regardless of Hours
                    of  Service.

          NOTE:  If  a.1.iii  or  iv is selected, the Plan could violate minimum
          participation and coverage requirements under Code Sections 401(a)(26)
          and  410.

          b.  With respect to the allocation of Employer Matching Contributions,
          a  Participant:

          1.  For  Plan  Years  beginning  after  1989,

               i.   (  )  N/A, Plan does not provide for matching contributions.
               ii.  (  )  shall share in the allocations, regardless of Hours of
                    Service.
               iii. ( ) shall share in the allocations provided such Participant
                    completed  more  than  500  Hours  of  Service.
               iv.  (  )  shall  share  in  such  allocations  provided  such
                    Participant  completed  a  Year  of  Service.
               v.   (X) shall not share in such allocations, regardless of Hours
                    of  Service.

          2.  For  Plan  Years  beginning  before  1990,

               i.   (X)  N/A,  new  Plan, or same as years beginning after 1989.
               ii.  (  )  shall share in the allocations, regardless of Hours of
                    Service.
               iii. (  )  shall  share  in  such  allocations  provided  such
                    Participant  completed  a  Year  of  Service.
               iv.  ( ) shall not share in such allocations, regardless of Hours
                    of  Service.

          NOTE:  If  b.1.iv  or  v  is  selected, the Plan could violate minimum
          participation  and coverage requirements under Code Section 401(a)(26)
          and  410.

E9     LIMITATIONS  ON  ALLOCATIONS  (Plan  Section  4.4)

     a.   If  any  Participant is or was covered under another qualified defined
          contribution  plan  maintained by the Employer, other than a Master or
          Prototype  Plan,  or if the Employer maintains a welfare benefit fund,
          as  defined  in Code Section 419(e), or an individual medical account,
          as  defined in Code Section 415(l)(2), under which amounts are treated
          as  Annual  Additions  with  respect  to any Participant in this Plan:

          1.   (X)  N/A.
          2.   ( ) The provisions of Section 4.4(b) of the Plan will apply as if
               the  other  plan  were  a  Master  or  Prototype  Plan.
          3.   (  )  Provide  the  method under which the Plans will limit total
               Annual  Additions  to  the  Maximum  Permissible Amount, and will
               properly  reduce  any  Excess Amounts, in a manner that precludes
               Employer  discretion.

     b.   If  any  Participant  is  or  ever has been a Participant in a defined
          benefit  plan  maintained  by  the  Employer:

          1.   (X)  N/A.
          2.   (  ) In any Limitation Year, the Annual Additions credited to the
               Participant  under this Plan may not cause the sum of the Defined
               Benefit  Plan  Fraction  and the Defined Contribution Fraction to
               exceed  1.0.  If the Employer's contribution that would otherwise
               be  made  on  the Participant's behalf during the limitation year
               would  cause  the  1.0  limitation  to  be  exceeded, the rate of
               contribution  under  this Plan will be reduced so that the sum of
               the  fractions  equals  1.0.  If  the  1.0 limitation is exceeded
               because  of  an Excess Amount, such Excess Amount will be reduced
               in  accordance  with  Section  4.4(a)(4)  of  the  Plan.
          3.   (  )  Provide  the  method  under  which  the Plans involved will
               satisfy  the  1.0  limitation in a manner that precludes Employer
               discretion.

E10  DISTRIBUTIONS UPON DEATH (Plan Section 6.6(h)) Distributions upon the death
     of  a  Participant  prior  to  receiving  any  benefits  shall

     a.   (X)  be  made  pursuant  to  the  election  of  the  Participant  or
          beneficiary.
     b.   (  )  begin within 1 year of death for a designated beneficiary and be
          payable  over  the  life  (or  over  a  period  not exceeding the life
          expectancy) of such beneficiary, except that if the beneficiary is the
          Participant's spouse, begin within the time the Participant would have
          attained  age  70  1/2.
     c.   (  )  be  made  within  5  years  of  death  for  all  beneficiaries.
     d.   (  )  other  ___

E11  LIFE  EXPECTANCIES (Plan Section 6.5(f)) for minimum distributions required
     pursuant  to  Code  Section  401(a)(9)  shall

     a.   ( )   be  recalculated  at  the  Participant's  election.
     b.   (X)   be  recalculated.
     c.   ( )   not  be  recalculated.


E12  CONDITIONS  FOR  DISTRIBUTIONS  UPON  TERMINATION  Distributions  upon
     termination  of employment pursuant to Section 6.4(a) of the Plan shall not
     be  made  unless  the  following  conditions  have  been  satisfied:

     a.   (X)  N/A.  Immediate  distributions  may  be  made  at  Participant's
          election.
     b.   ( )  The  Participant  has  incurred ____ 1-Year Break(s) in Service.
     c.   ( )  The Participant has reached his or her Early or Normal Retirement
          Age.
     d.   ( )  Distributions  may  be  made at the Participant's election on or
          after  the  Anniversary  Date  following  termination  of  employment.
     e.   ( )  Other  ___

E13  FORM  OF  DISTRIBUTIONS (Plan Sections 6.5 and 6.6) Distributions under the
     Plan  may  be  made

     a.   1.  ( )  in  lump  sums.
          2.  (X)  in  lump  sums  or  installments.

     b.  AND,  pursuant  to  Plan  Section  6.13,

          1.  (X)  no  annuities  are allowed (avoids Joint and Survivor rules).
          2.  ( )  annuities  are  allowed (Plan Section 6.13 shall not apply).

     NOTE: b.1. above may not be elected if this is an amendment to a plan which
          permitted  annuities  as  a  form  of distribution or if this Plan has
          accepted a plan to plan transfer of assets from a plan which permitted
          annuities  as  a  form  of  distribution.

     c.   AND,  may  be  made  in

          1.  (X)  cash  only  (except  for  insurance  or  annuity  contracts).
          2.  ( )  cash  or  property.



TOP  HEAVY  REQUIREMENTS


F1   TOP  HEAVY DUPLICATIONS (Plan Section 4.3(i)): When a Non-Key Employee is a
     Participant  in  this  Plan  and  a  Defined Benefit Plan maintained by the
     Employer,  indicate  which method shall be utilized to avoid duplication of
     top  heavy  minimum  benefits.

     a.   (X)  The  Employer  does  not  maintain  a  Defined  Plan.
     b.   (  )  A  minimum,  non-integrated  contribution  of 5% of each Non-Key
          Employee's  total  Compensation  shall  be  provided  in this Plan, as
          specified  in  Section  4.3(i).  (The  Defined  Benefit  and  Defined
          Contribution  Fractions  will be computed using 100% if this choice is
          selected.)
     c.   (  )  A minimum, non-integrated contribution of 7 1/2% of each Non-Key
          Employee's  total  Compensation  shall  be  provided  in this Plan, as
          specified  in Section 4.3(i). (If this choice is selected, the Defined
          Benefit and Defined Contribution Fractions will be computed using 125%
          for  all  Plan Years in which the Plan is Top Heavy, but not Super Top
          Heavy.)
     d.   (  )  Specify  the method under which the Plans will provide top heavy
          minimum  benefits  for  Non-Key  Employees that will preclude Employer
          discretion  and avoid inadvertent omissions, including any adjustments
          required  under  Code  Section  415(e).

F2   PRESENT  VALUE OF ACCRUED BENEFIT (Plan Section 2.2) for Top Heavy purposes
     where  the  Employer  maintains  a Defined Benefit Plan in addition to this
     Plan,  shall  be  based  on

     a.   (X)  N/A.  The  Employer  does  not  maintain  a defined benefit plan.

     b.   (  )  Interest  Rate:  ____

                 Mortality  Table:  ____

F3   TOP  HEAVY  DUPLICATIONS:  Employer  maintaining  two  (2)  or more Defined
     Contribution  Plans.

     a.   (X)  N/A.
     b.   ( )  A  minimum,  non-integrated  contribution  of 3% of each Non-Key
          Employee's  total Compensation shall be provided in the Money Purchase
          Plan  (or  other plan subject to Code Section 412), where the Employer
          maintains  two (2) or more non-paired Defined Contribution Plans.
     c.   ( )  Specify  the  method under which the Plans will provide top heavy
          minimum  benefits  for  Non-Key  Employees that will preclude Employer
          discretion  and avoid inadvertent omissions, including any adjustments
          required  under  Code  Section  415(e).



MISCELLANEOUS

G1   LOANS  TO  PARTICIPANTS  (Plan  Section  7.5)

     a.   (X)  Yes,  loans  may  be  made  up to $50,000 or 1/2 Vested interest.
     b.   ( )  No,  loans  may  not  be  made.

     If   YES,  (check  all  that  apply)

     c.   (X)  loans  shall  be  treated  as  a  Directed  Investment.
     d.   ( )  loans  shall  only  be made for hardship or financial necessity.
     e.   (X)  the  minimum  loan  shall  be  $500.

     NOTE:  Department  of  Labor Regulations require the adoption of a SEPARATE
          written  loan  program setting forth the requirements outlined in Plan
          Section  7.5.

G2   DIRECTED  INVESTMENT  ACCOUNTS  (Plan  Section  4.8)  are permitted for the
     interest  in  any  one  or  more  accounts.

     a.   (X) Yes, regardless of the Participant's Vested interest in the Plan.
     b.   ( ) Yes, but only with respect to the Participant's Vested interest in
          the  Plan.
     c.   ( ) Yes,  but  only  with  respect  to those accounts which are 100%
          Vested.
     d.   ( )  No  directed  investments  are  permitted.

G3   TRANSFERS  FROM  QUALIFIED  PLANS  (Plan  Section  4.6)

     a.   (X)  Yes,  transfers  from  qualified  plans  (and  rollovers) will be
          allowed.
     b.   ( )  No,  transfers  from qualified plans (and rollovers) will not be
          allowed.

     AND, transfers  shall  be  permitted

     c.   (X)  from  any  Employee,  even  if  not  a  Participant.
     d.   ( )  from  Participants  only.

G4   EMPLOYEES'  VOLUNTARY  CONTRIBUTIONS  (Plan  Section  4.7)

     a.   ( ) Yes, Voluntary Contributions are allowed subject to the limits of
          Section  4.10
     b.   (X)  No,  Voluntary  Contributions  will  not  be  allowed.

     NOTE:  TRA  '86  subjects  voluntary contributions to strict discrimination
          rules.

G5   HARDSHIP  DISTRIBUTIONS  (Plan  Sections  6.11  and  11.8)

     a.   (X)  Yes,  from  any  accounts.
     b.   ( )  Yes,  from  Participant's  Elective  Account  only.
     c.   ( )  Yes,  but  limited  to  the  Participant's  Account  only.
     d.   ( )  No.

     NOTE:  Distributions  from  a Participant's Elective Account are limited to
          the  portion  of  such  account  attributable  to  such  Participant's
          Deferred Compensation and earnings attributable thereto up to December
          31,  1988.  Also  hardship  distributions  are  not  permitted  from a
          Participant's  Qualified  Non-Elective  Account.

G6     PRE-RETIREMENT  DISTRIBUTION  (Plan  Section  6.10)

     a.   (X)  If a Participant has reached the age of 59 1/2, distributions may
          be  made,  at  the  Participant's  election, from any accounts without
          requiring  the  Participant  to  terminate  employment.
     b.   ( )  No  pre-retirement  distribution  may  be  made.

     NOTE:Distributions  from  a  Participant's Elective Account and Qualified
          Non-Elective  Account  are  not  permitted  prior  to  age  59  1/2.


The  adopting  Employer may not rely on an opinion letter issued by the National
Office  of  the  Internal Revenue Service as evidence that the plan is qualified
under  Code  Section  401.  In  order  to  obtain  reliance with respect to plan
qualification,  the  Employer  must apply to the appropriate Key District Office
for  a  determination  letter.

This Adoption Agreement may be used only in conjunction with basic Plan document
01.  This Adoption Agreement and the basic Plan document shall together be known
as  Automatic  Data  Processing  Non-Standardized 401(k) Profit Sharing Plan and
Trust  01-001.

The  adoption  of  this  Plan, its qualification by the IRS, and the related tax
consequences  are the responsibility of the Employer and its independent tax and
legal  advisors.

Automatic Data Processing will notify the Employer of any amendments made to the
Plan  or of the discontinuance or abandonment of the Plan. Furthermore, in order
to  be  eligible to receive such notification, we agree to notify Automatic Data
Processing  of  any  change  in  address.



IN  WITNESS  WHEREOF,  the  Employer  and  Trustee  hereby cause this Plan to be
executed  on  August  21,  2001.
              -----------------

EMPLOYER:

Exelixis,  Inc.

By:______________________


_________________________              ___________________________
       TRUSTEE                                   TRUSTEE

_________________________              ___________________________
       TRUSTEE                                   TRUSTEE

_________________________
       TRUSTEE

PARTICIPATING  EMPLOYER:

________________________
     (enter  name)

By:_____________________

With  regard  to any questions regarding the provisions of the Plan, adoption of
the  Plan,  or the effect of an opinion letter from the IRS, call or write (this
information  must  be  completed  by  the sponsor of this Plan or its designated
representative):

Name          _________________________________________________________________

Address       _________________________________________________________________

              _________________________________________________________________

Telephone    (     ) __________________________________________________________