EXHIBIT 10.33





                               SUBLEASE AGREEMENT
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Toshiba  America  Medical Systems, Inc. ("TAMS"), located at 280 Utah Ave, South
San  Francisco,  CA,  and  Exelixis, Inc. ("TENANT"), located at 170 Harbor Way,
South  San  Francisco,  CA  hereby  agree (the "Sublease Agreement") as follows:

1.   SUBLEASE.  TAMS  hereby  subleases  to  TENANT  approximately  8,000 square
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     feet  (the  "Premises") of the space leased by TAMS at 280 Utah Ave., South
     San  Francisco,  CA,  (the  "Facility")  under  the Lease Agreement ("Lease
     Agreement")  entered  into  between  TAMS and Simeon Commercial Properties,
     Inc.  ("Landlord").  The  Lease  Agreement  is  attached hereto and by this
     reference is deemed incorporated into this Sublease Agreement. The Premises
     is  identified  on  the  attached  "Exhibit  B".

2.   NO  WARRANTIES.  Except  for  delivery  of  the  Premises  in  broom  clean
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     condition,  TAMS  subleases  the  Premises  to  TENANT  AS  IS, without any
     warranties  whatsoever  concerning  the  condition  of  the Premises or the
     suitability of the same for TENANT's purposes. To the extent required, TAMS
     must  obtain the consent of Landlord as a condition to the effectiveness of
     this  Sublease  Agreement.

3.   TERM.  The  term  of  this Sublease Agreement will begin on May 1, 2002 and
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     end  on March 31, 2004. However, TAMS may terminate this Sublease Agreement
     upon  thirty  (30)  days prior written notice during its term should TENANT
     breach any of the terms and conditions specified in the Sublease Agreement.
     TAMS  may  also  avail itself of any other remedies provided under the law.

4.   RENTAL.  The  monthly  rental  to  be  paid  by  TENANT will be as follows:
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     March  1,  2002  through  March  31,  2003  -          $10,800.00
     April  1,  2003  through  March  31,  2004  -          $11,120.00

     The  first installment of rent ($10,800.00) shall be paid upon execution of
     this  Sublease  Agreement.  Future installments, along with any "additional
     rent", as specified herein, will be paid in advance no later than the first
     day  of  each  month  throughout the term of this Sublease Agreement at the
     following  address  (or  any  other  to  be  designated  by  TAMS):

     TOSHIBA  AMERICA  MRI,  INC.
     280  Utah  Avenue,
     South  San  Franciso,  Ca.  94080
     Attention:  Accounts  Payable

     All  rentals  paid after due date will be assessed a late payment charge of
     the  lesser  of 1 1/2% per month or the maximum rate permitted by law. TAMS
     may require TENANT to pay the rent quarterly, in advance, if TENANT tenders
     late rent payments on three (3) or more occasions during the sublease term.
     Should  TAMS take such action, it does not constitute a waiver of any other
     rights  or  remedies TAMS may have regarding late or non-payment of rent by
     tenant.

5.   OPERATING  EXPENSES,  UTILITIES  AND  TAXES.  In  addition  to  the
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     obligations  specified  in  Section  4  above,  TENANT  shall  pay  for:

     -    All  Personal  property  taxes  associated  with the use, occupancy or
          contents  of  the  Premises.
     -    All  costs  related  to  the  security,  housekeeping,
          data/telecommunications  (service,  equipment  and  maintenance)  and
          maintenance  of  the  Premises.
     -    Tenant's proportionate share of all costs associated with the Premises
          where such costs are billed to TAMS as part of the overall cost of the
          Facility.

     To  the  extent  that  such  payments  will be made directly to the service
     provider  by  TENANT, TENANT will make each payment when due. Proportionate
     share  payments  will  be considered "additional rent", and must be paid to
     TAMS  in  accordance  with  Section  4  above.

6.   PARKING.  TENANT  may  use  all  parking  and shall pay for the same to the
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     extent  specified  in  the  Lease Agreement. But in no event will TENANT be
     allowed  to  use  more  than  32  parking  spaces  at  any  one  time

8.   SECURITY  DEPOSIT.  Upon  execution  of  this Sublease Agreement, TENANT is
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     to pay TAMS the sum of $10,800 (Ten Thousand and Eight Hundred dollars), to
     be  used  as  security  deposit for the performance of TENANT's obligations
     under  this Sublease Agreement including, without limitation, the surrender
     of  possession  of the Premises to TAMS upon expiration of the term of this
     Sublease Agreement. It is expressly understood and agreed that such deposit
     is  not  an advance rental deposit or a measure of TAMS' damages in case of
     TENANT's  default. If TAMS applies any part of the security deposit to cure
     any  default  of  TENANT,  TENANT  will, upon demand, deposit with TAMS the
     amount  so  applied  so that TAMS will have the full deposit on hand at all
     times  during  the term of this Sublease Agreement. No interest will be due
     on  the  security  deposit  and  TAMS  will  not  be obligated to apply the
     security  deposit  to  rents  or other charges in arrears or to damages for
     TENANT's  failure  to  perform under this Sublease Agreement. However, TAMS
     may  so  apply  the  security  deposit  at TAMS' option, and TAMS' right to
     possession  of  the Premises for nonpayment of rent or for any other reason
     will  not in any way be affected by reason of the fact that TAMS holds such
     security  deposit.

     Based  on  the  obligations  set  forth  in  Section  4 and this Section 8,
     Tenant's payment obligation upon execution of this Sublease Agreement shall
     be  $21,600.00  (Twenty  One  Thousand  and  Six  Hundred  Dollars).

9.   TENANT  IMPROVEMENTS.  TAMS will, it its sole expense, construct a demising
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     wall, as noted on Exhibit B. Any and all other improvements required by the
     TENANT will be at the sole expense of the TENANT, and must approved by TAMS
     per  the  terms  of  the  Lease  Agreement.

10.  FINANCIAL  INFORMATION.  TENANT  will  provide  TAMS  with  all  financial
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     information  reasonably  requested  by  TAMS from time to time to determine
     TENANT's  ability  to  comply  with  its  obligations  under  this Sublease
     Agreement.

11.  ASSUMPTION  OF  OBLIGATIONS.  TENANT  agrees  to  fully  perform all of the
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     obligations  of  TAMS  (except  TAMS' obligation to pay rent, and except as
     otherwise  specified  in  this  Sublease  Agreement) under the terms of the
     Lease  Agreement with respect to the Premises and to accord TAMS all of the
     rights,  privileges,  and  indemnities  with  respect  to  and from TAMS to
     Landlord  under  the  Lease  Agreement and agrees that all of the terms and
     conditions  of  the  Lease  Agreement as applied to the Premises are hereby
     incorporated in this Sublease Agreement, including, without limitation, the
     obligation  to  maintain  and  repair  the  Premises.

12.  INDEMNIFICATION.  TENANT  will  defend,  indemnify,  and hold TAMS harmless
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     from  all  claims,  damages,  liabilities,  and costs (including attorney's
     fees)  arising out of TENANT's failure to comply with its obligations under
     this  Sublease  Agreement or otherwise arising out of TENANT's occupancy of
     the  Premises,  including,  without  limitation,  any  claim  made  by  the
     Landlord.  TAMS  will  defend, indemnify, and hold TENANT harmless from all
     claims, damages, liabilities, and costs (including attorney's fees) arising
     out  of  failure by TAMS to comply with its obligations under this Sublease
     Agreement  or  the  Master  Lease, including, without limitation, any claim
     made  by  Landlord against TENANT with respect to such failure or breach by
     TAMS.

13.  ATTORNEY'S  FEES.  In  the  event  of  any  legal  proceeding involving any
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     party  to this Sublease Agreement against the other relating to the subject
     matter  of this Sublease Agreement, the prevailing party in such proceeding
     will  be  entitled to recover attorney's fees, expert fees, and court costs
     against  the  non-prevailing  party.

14.  USE  OF  FACILITY  LOBBY.  TENANT,  its  employees,  guests  and  invitees
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     may  use  the  Facility  Lobby  entrance  but none of the services provided
     therein,  other  than  the  use of the vending machine area, restrooms, and
     elevator  which  are  considered as part of the common shared rental space.

15.  ENTIRE  AGREEMENT;  MODIFICATION.  This  Agreement  and  its  attachments
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     contain the entire agreement and understanding between the parties relating
     to  its  subject  matter.  It  supersedes  all  prior  agreements  and
     understandings,  whether  oral or written, relating to such subject matter.
     It  also  supersedes  all  standard  terms and conditions on any form to be
     exchanged  between  the  parties, including, invoice, purchase order, order
     acknowledgment, quotation and delivery documents. This Agreement may not be
     amended  or modified in any manner except by means of a writing executed by
     all  parties.



TOSHIBA  AMERICA  MEDICAL  SYSTEMS,  INC.        EXELIXIS,  INC.



BY:   /s/ Fredric J. Friedberg                   BY: /s/ George A. Scangos
      -------------------------                      --------------------------
      FREDRIC  J.  FRIEDBERG                         GEORGE  A.  SCANGOS  PH.D.
      SENIOR  VICE  PRESIDENT                        PRESIDENT  &  CEO


DATED: April 12, 2002                            DATED: April 8, 2002
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