EXHIBIT 10.34

                         LOAN  AND  SECURITY  AGREEMENT

                              Exelixis,  Inc.






                                TABLE OF CONTENTS
                              -------------------


     HEADING                                                                        PAGE
     -------                                                                       -----
                                                                               

     1.    ACCOUNTING AND OTHER TERMS . . . . . . . . . . . . . . . . . . . . . . .    1

     2.    LOAN AND TERMS OF PAYMENT. . . . . . . . . . . . . . . . . . . . . . . .    1
           2.1    Promise to Pay . .  . . . . . . . . . . . . . . . . . . . . . . .    1
           2.2    Overadvances. . . . . . . . . . . . . . . . . . . . . . . . . . .    1
           2.3    Interest Rate, Payments . . . . . . . . . . . . . . . . . . . . .    2
           2.4    Fees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .    2

     3.    CONDITIONS OF LOANS. . . . . . . . . . . . . . . . . . . . . . . . . . .    3
           3.1    Conditions Precedent to Initial Credit Extension. . . . . . . . .    3
           3.2    Conditions Precedent to all Credit Extensions . . . . . . . . . .    3

     4.    CREATION OF SECURITY INTEREST. . . . . . . . . . . . . . . . . . . . . .    3

     5.    REPRESENTATIONS AND WARRANTIES . . . . . . . . . . . . . . . . . . . . .    3
           5.1    Due Organization and Authorization. . . . . . . . . . . . . . . .    3
           5.2    Collateral. . . . . . . . . . . . . . . . . . . . . . . . . . . .    3
           5.3    Litigation. . . . . . . . . . . . . . . . . . . . . . . . . . . .    4
           5.4    No Material Adverse Change in Financial Statements. . . . . . . .    4
           5.5    Regulatory Compliance . . . . . . . . . . . . . . . . . . . . . .    4
           5.6    Full Disclosure . . . . . . . . . . . . . . . . . . . . . . . . .    4

     6.    AFFIRMATIVE COVENANTS. . . . . . . . . . . . . . . . . . . . . . . . . .    4
           6.1    Government Compliance . . . . . . . . . . . . . . . . . . . . . .    4
           6.2    Financial Statements, Reports, Certificates . . . . . . . . . . .    5
           6.3    Taxes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .    5
           6.4    Deposits. . . . . . . . . . . . . . . . . . . . . . . . . . . . .    5
           6.5    Further Assurances. . . . . . . . . . . . . . . . . . . . . . . .    5

     7.    NEGATIVE COVENANTS . . . . . . . . . . . . . . . . . . . . . . . . . . .    5
           7.1    Dispositions. . . . . . . . . . . . . . . . . . . . . . . . . . .    5
           7.2    Changes in Business, Ownership, Management or Business Locations.    6
           7.3    Indebtedness. . . . . . . . . . . . . . . . . . . . . . . . . . .    6
           7.4    Encumbrances. . . . . . . . . . . . . . . . . . . . . . . . . . .    6
           7.5    Distributions; Investments. . . . . . . . . . . . . . . . . . . .    6
           7.6    Transactions with Affiliates. . . . . . . . . . . . . . . . . . .    6
           7.7    Subordinated Debt.. . . . . . . . . . . . . . . . . . . . . . . .    6
           7.8    Compliance. . . . . . . . . . . . . . . . . . . . . . . . . . . .    6

     8.    EVENTS OF DEFAULT. . . . . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.1    Payment Default.. . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.2    Covenant Default. . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.3    Material Adverse Change.. . . . . . . . . . . . . . . . . . . . .    7
           8.4    Attachment. . . . . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.5    Insolvency. . . . . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.6    Other Agreements. . . . . . . . . . . . . . . . . . . . . . . . .    7
           8.7    Judgments.. . . . . . . . . . . . . . . . . . . . . . . . . . . .    8
           8.8    Misrepresentations. . . . . . . . . . . . . . . . . . . . . . . .    8

     9.    BANK'S RIGHTS AND REMEDIES . . . . . . . . . . . . . . . . . . . . . . .    8
           9.1    Rights and Remedies.. . . . . . . . . . . . . . . . . . . . . . .    8
           9.2    Power of Attorney.. . . . . . . . . . . . . . . . . . . . . . . .    8
           9.3    Bank Expenses.. . . . . . . . . . . . . . . . . . . . . . . . . .    8
           9.4    Bank's Liability for Collateral.. . . . . . . . . . . . . . . . .    9
           9.5    Remedies Cumulative . . . . . . . . . . . . . . . . . . . . . . .    9
           9.6    Demand Waiver . . . . . . . . . . . . . . . . . . . . . . . . . .    9

    10.    NOTICES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .    9

    11.    CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER . . . . . . . . . . . . . . .    9

    12.    GENERAL PROVISIONS . . . . . . . . . . . . . . . . . . . . . . . . . . .    9
           12.1    Successors and Assigns . . . . . . . . . . . . . . . . . . . . .    9
           12.2    Indemnification. . . . . . . . . . . . . . . . . . . . . . . . .   10
           12.3    Time of Essence. . . . . . . . . . . . . . . . . . . . . . . . .   10
           12.4    Severability of Provision. . . . . . . . . . . . . . . . . . . .   10
           12.5    Amendments in Writing, Integration . . . . . . . . . . . . . . .   10
           12.6    Counterparts . . . . . . . . . . . . . . . . . . . . . . . . . .   10
           12.7    Survival . . . . . . . . . . . . . . . . . . . . . . . . . . . .   10
           12.8    Confidentiality. . . . . . . . . . . . . . . . . . . . . . . . .   10
           12.9    Attorneys' Fees, Costs and Expenses. . . . . . . . . . . . . . .   11

    13.    DEFINITIONS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .   11


EXHIBITS
- --------
Exhibit  A  -  Description  of  Collateral
Exhibit  B  -  Loan  Payment/Advance  Request  Form
Exhibit  C  -  Form  of  Loan  Agreement  Supplement
Exhibit  D  -  Form  of  Compliance  Certificate



     This LOAN AND SECURITY AGREEMENT dated May 22, 2002, between SILICON VALLEY
BANK,  a  California-chartered bank ("Bank") whose address is 3003 Tasman Drive,
Santa  Clara,  California  95054,  and  EXELIXIS,  INC.,  a Delaware corporation
("Borrower") whose address is 170 Harbor Way, P.O. Box 511, South San Francisco,
California  94083,  provides  the  terms on which Bank will lend to Borrower and
Borrower  will  borrow  from  Bank.  The  parties  agree  as  follows:

1.   ACCOUNTING  AND  OTHER  TERMS.
     -----------------------------

     Accounting  terms  not  defined  in  this  Agreement  will  be construed in
accordance with GAAP. Calculations and determinations must be made in accordance
with GAAP. The term "financial statements" includes the notes and schedules. The
terms  "including"  and  "includes" always mean "including (or includes) without
limitation,"  in  this  or  any  Loan  Document.

2.   LOAN  AND  TERMS  OF  PAYMENT.
     -----------------------------

2.1  PROMISE  TO  PAY.
     ----------------

     Borrower  promises  to  pay  Bank the unpaid principal amount of all Credit
Extensions and interest on the unpaid principal amount of all Credit Extensions.

2.1.1  EQUIPMENT  ADVANCES.
       -------------------

     (a)  Subject  to the terms and conditions of this Agreement, Bank agrees to
lend  to  Borrower, from the Closing Date until the Commitment Termination Date,
equipment  advances  (the  "Equipment  Advances")  in an aggregate amount not to
exceed the Committed Equipment Line. When repaid, the Equipment Advances may not
be  re-borrowed.  The  proceeds of each Equipment Advance will be used solely to
reimburse  Borrower  for  100% of the Original Stated Cost of Eligible Equipment
purchased. Bank's obligation to lend hereunder shall terminate on the earlier of
(i)  the  occurrence  and  continuance  of  an  Event  of  Default,  or (ii) the
Commitment  Termination  Date.  For  purposes of this Section 2.1.1, the maximum
number of Equipment Advances that may be made is eight and the minimum amount of
each  Equipment  Advance (except for the Initial Equipment Advance and the final
Equipment  Advance)  shall  be  $500,000.

     (b) To obtain an Equipment Advance, Borrower will deliver to Bank, at least
three (3) Business Days before the proposed funding date (the "Funding Date"), a
completed  supplement  in  the  form  attached  as Exhibit C ("Loan Supplement")
signed  by  a  Responsible  Officer  or  his or her designee and such additional
information  as  Bank may request. On the Funding Date, Bank will specify in the
Loan  Supplement the Basic Rate, the periodic principal payments and the Payment
Dates, all in accordance with the terms of this Agreement. If Borrower satisfies
the  conditions  of  the Equipment Advances specified herein, Bank will disburse
such  Equipment  Advance by internal transfer to Borrower's deposit account with
Bank.  The  Loan  Supplement  for  each  Equipment Advance shall be considered a
promissory  note  evidencing  the  amounts  due  under  such  Equipment Advance.

2.2  OVERADVANCES.
     ------------

     If  the  Obligations  under Sections 2.1.1 at any time exceed the Committed
Equipment  Line or the principal balance of the segregated securities account(s)
required  by  Section  6.4 hereof at any time is less than 110% of the principal
portion  of  the  Obligations,  then  Borrower  will be in an Overadvance to the
extent  of  such  excess amount. If Borrower is in an Overadvance, then Borrower
shall  immediately  repay  to  Bank  such  excess  amount.

2.3  INTEREST  RATE,  PAYMENTS.
     -------------------------

2.3.1  EQUIPMENT  ADVANCES.

     (a)  Borrower  will  repay  each  of  the  Equipment  Advances on the terms
provided  in  the  Loan  Supplement for such Equipment Advance, effected through
debits of Borrower's accounts as provided in Section 2.3.2 hereof. Borrower will
make  48 equal monthly payments of principal in arrears, plus accrued and unpaid
interest  (collectively,  "Scheduled Payments"), on the last Business Day of the
month  following  the  Funding  Date  (or commencing on the Funding Date, if the
Funding  Date  is  the last Business Day of the month) and continuing thereafter
during  the  Repayment  Period  on  the last Business Day of each calendar month
(each,  a  "Payment  Date"),  and all then-outstanding principal and accrued and
unpaid interest as to each Equipment Advance shall be due and payable in full on
the  Maturity  Date  for  that  Equipment Advance. Payments received after 12:00
noon,  Pacific  Time,  are considered received at the opening of business on the
next  Business  Day.

     (b)  Borrower  will pay interest on the Payment Dates at the per annum rate
of  interest  equal  to  the Basic Rate, as the Basic Rate may from time to time
change.  Any  amounts  outstanding during the continuance of an Event of Default
shall  bear  interest  at  a  per  annum  rate equal to the Basic Rate plus five
percent  (5.00%).  If  any  change  in  the law after the date of this Agreement
increases  Bank's  expenses or decreases its return from the Equipment Advances,
Borrower  will  pay Bank upon request the amount of such increase of expenses or
an  amount  equal  to  the difference between Bank's anticipated return from the
Equipment  Advances  and  the decreased return actually received by Bank (as the
case  may  be).

     (c)  If  the Equipment Advances are accelerated following the occurrence of
an  Event  of  Default,  then  Borrower  will  immediately  pay to Bank, without
duplication,  (i)  all  unpaid  Scheduled  Payments  (including  principal  and
interest), (ii) all principal with respect to remaining Scheduled Payments (iii)
all accrued unpaid interest, including the default rate of interest, to the date
of  the  prepayment, and (iv) all other sums, if any, that shall have become due
and  payable  with  respect  to  the  Equipment  Advances.

     (d)  Borrower  shall have the option to prepay, without penalty or premium,
the  Equipment Advances in whole or in part at any time; provided, however, that
Borrower  (i) gives written notice to Bank of its election to prepay at least 30
days  prior  to  such  prepayment  and (ii) pays, on the date of the prepayment,
without  duplication, (A) all unpaid Scheduled Payments (including principal and
interest)  with  respect  to  the  Equipment  Advances  to  be prepaid, (B) such
principal  portion  of the Equipment Advance as Borrower notified Bank was to be
prepaid,  (C) all unpaid accrued interest on the principal portion so prepaid to
the  date  of  the  prepayment,  and (D) all other sums, if any, that shall have
become  due  and  payable  hereunder  with  respect to such principal portion so
prepaid.

2.3.2  DEBIT  OF  BORROWER'S  ACCOUNTS.

     Bank  will  debit  any  of  Borrower's  deposit accounts, including Account
Number  3300161062,  for  principal and interest payments, and any other amounts
Borrower owes Bank when due. Bank will notify Borrower when it debits Borrower's
accounts.  Any  such  debits  are  not  a  set-off.

2.4  FEES.
     ----
     (a)  Borrower  will  pay all Bank Expenses (including reasonable attorneys'
fees  and  reasonable  expenses)  incurred  through  and  after the date of this
Agreement,  provided,  however,  that Borrower's obligation to pay Bank Expenses
incurred  through the Closing Date shall be limited to $3,000. All Bank Expenses
are  due  and  payable  upon  demand  from  Bank.

     (b)  Borrower  will  pay  the  Loan  Fee  on  or  before  the Closing Date.

3.   CONDITIONS  OF  LOANS.

3.1  CONDITIONS  PRECEDENT  TO  INITIAL  CREDIT  EXTENSION.
     -----------------------------------------------------

     Bank's obligation to make the initial Credit Extension is subject to Bank's
having  received  the  agreements,  documents  and  fees  that  it  requires.

3.2  CONDITIONS  PRECEDENT  TO  ALL  CREDIT  EXTENSIONS.
     --------------------------------------------------

     Bank's  obligations  to  make  each Credit Extension, including the initial
Credit  Extension,  is  subject  to  the  following:

     (a)  Bank shall have received any Loan Payment/Advance Request Form and any
Loan  Supplement.

     (b)  The  representations  and warranties in Section 5 shall be true in all
material  respects  on  the  date  of  the  Payment/Advance  Form  and  the Loan
Supplement,  and on the effective date of each Credit Extension, and no Event of
Default  may  have  occurred  and  be  continuing,  or  result  from  the Credit
Extension.  Each  Credit  Extension is Borrower's representation and warranty on
that  date  that  the representations and warranties of Section 5 remain true in
all  material  respects.

     (c) Borrower shall have opened its primary operating accounts with Bank and
shall  have  opened  a  segregated investment account with the Bank's Investment
Products  and  Services  Division  with  a principal balance in an amount at all
times  equal  to  not less than 110% of the principal portion of the Obligations
plus  the  amount  of the requested Credit Extension(s).

4.   CREATION  OF  SECURITY  INTEREST.

     Borrower  grants  Bank a continuing first priority security interest in all
presently  existing  and later acquired Collateral to secure all Obligations and
the  performance of each of Borrower's duties under the Loan Documents. Bank may
place  a  "hold"  on  any  deposit  account and/or securities account pledged as
Collateral.  If  this Agreement is terminated, Bank's lien and security interest
in  the Collateral will continue until Borrower fully satisfies its Obligations.

5.   REPRESENTATIONS  AND  WARRANTIES.

     Borrower  represents  and  warrants  as  follows:

5.1  DUE  ORGANIZATION  AND  AUTHORIZATION.
     -------------------------------------

     Borrower  and  each Subsidiary is duly existing and in good standing in its
jurisdiction  of  formation and is qualified and licensed to do business in, and
in  good  standing in, each jurisdiction in which the conduct of its business or
its  ownership  of  property  requires  that  it  be qualified, except where the
failure  to  do  so could not reasonably be expected to cause a Material Adverse
Change.  Borrower  is  a  Delaware  corporation.  The  execution,  delivery  and
performance  by Borrower of the Loan Documents have been duly authorized, and do
not  conflict  with  Borrower's  formation documents, nor constitute an event of
default under any material agreement by which Borrower is bound. Borrower is not
in  default  under  any  agreement to which or by which it is bound in which the
default  could  reasonably  be  expected  to  cause  a  Material Adverse Change.

5.2  COLLATERAL.
     ----------

     Borrower  has  good  title  to the Collateral, free of all Liens except the
Lien  in  favor  of  the  Bank.

5.3  LITIGATION.
     ----------

     Except  as  shown  in  the  Schedules,  there are no actions or proceedings
pending  or,  to the knowledge of Borrower's Responsible Officers, threatened by
or  against  Borrower  or  any  Subsidiary  in  which  an adverse decision could
reasonably  be  expected  to  cause  a  Material  Adverse  Change.

5.4  NO  MATERIAL  ADVERSE  CHANGE  IN  FINANCIAL  STATEMENTS.
     --------------------------------------------------------

     All  separate  or  consolidated  financial  statements for Borrower and any
Subsidiary  delivered  to  Bank  fairly  present  in  all material respects such
entity's  separate  and  consolidated  financial  condition  and  separate  and
consolidated  results  of  operations.  There  has  not  been  any  material
deterioration  in  Borrower's consolidated financial condition since the date of
the  most  recent  financial  statements  submitted  to  Bank.

5.5  REGULATORY  COMPLIANCE.
     ----------------------

     Neither  Borrower  nor  any  Subsidiary,  is  an  "investment company" or a
company  "controlled"  by  an  "investment company" under the Investment Company
Act.  Neither  Borrower  nor  any Subsidiary, is engaged, as one of its material
activities,  in  extending  credit  for  margin stock (under Regulations T and U
promulgated  by  the Board of Governors of the Federal Reserve System). Borrower
has complied in all material respects with the Federal Fair Labor Standards Act.
Borrower  has not violated any laws, ordinances or rules, the violation of which
could  reasonably  be  expected  to  cause  a  Material  Adverse Change. None of
Borrower's or any Subsidiary's properties or assets has been used by Borrower or
any  Subsidiary or, to the best of Borrower's knowledge, by previous Persons, in
disposing,  producing, storing, treating or transporting any hazardous substance
other  than  in  a legal manner in substantial compliance with all environmental
laws  and regulations. Each of Borrower and each Subsidiary has timely filed all
required  tax  returns and paid, or made adequate provision to pay, all material
taxes,  except  those being contested in good faith with adequate reserves under
GAAP.  Each of Borrower and each Subsidiary has obtained all consents, approvals
and  authorizations  of,  made  all  declarations or filings with, and given all
notices  to,  all  government  authorities  that  are  necessary to continue its
business  as  currently  conducted,  except where the failure to do so could not
reasonably  be  expected  to  cause  a  Material  Adverse  Change.

5.6  FULL  DISCLOSURE.
     ----------------

     No  written  representation, warranty or other statement of Borrower in any
certificate  or  written  statement  given to Bank (taken together with all such
written  certificates  and  written  statements  to  Bank)  contains  any untrue
statement of a material fact or omits to state a material fact necessary to make
the  statements  contained  in the certificates or statements not misleading, it
being recognized by Bank that the projections and forecasts provided by Borrower
in  good faith and based upon reasonable assumptions are not viewed as facts and
that actual results during the period or periods covered by such projections and
forecasts  may  differ  from  the  projected  and  forecasted  results.

6.   AFFIRMATIVE  COVENANTS.

     Borrower will do all of the following for so long as Bank has an obligation
to  lend,  or  there  are  outstanding  Obligations:

6.1  GOVERNMENT  COMPLIANCE.
     ----------------------

     Borrower  will  maintain its and all Subsidiaries' legal existence and good
standing in its respective jurisdictions of formation and maintain qualification
in  each  jurisdiction  in  which  the failure to so qualify could reasonably be
expected to result in a Material Adverse Change. Borrower will comply, and cause
each Subsidiary to comply, with all laws, ordinances and regulations to which it
is  subject,  noncompliance  with  which could reasonably be expected to cause a
Material  Adverse  Change.

6.2  FINANCIAL  STATEMENTS,  REPORTS,  CERTIFICATES.
     ----------------------------------------------

     (a)  Borrower  will deliver to Bank: (i) as soon as available, but no later
than  45  days  after  the  last  day  of  each  of  the first three quarters of
Borrower's  fiscal  year,  company-prepared  unaudited separate and consolidated
balance  sheets  and  income  statements  covering the separate and consolidated
operations  of Borrower and its Subsidiaries during the fiscal quarter (with the
exception of when annual statements are due), certified by a Responsible Officer
and in a form acceptable to Bank; (ii) as soon as available but no later than 90
days  after  the  last  day  of  Borrower's  fiscal  year,  audited separate and
consolidated  financial  statements  for  Borrower and all Subsidiaries prepared
under  GAAP,  consistently  applied, together with an unqualified opinion on the
financial  statements  from  an  independent  certified  public  accounting firm
reasonably  acceptable  to  Bank; (iii) except as otherwise disclosed in filings
with  the  U.S. Securities and Exchange Commission, a prompt report of any legal
actions  pending  or  threatened  against  Borrower or any Subsidiary that could
result  in damages or costs to Borrower or any Subsidiary of $5,000,000 or more;
and  (iv)  any  Forms  10-K and 10-Q filed with the U.S. Securities and Exchange
Commission,  within  10  days  of  such  filing.

     (b)  Concurrently  with  the delivery of the quarterly and annual financial
statements,  Borrower  will deliver to Bank a Compliance Certificate in the form
of  Exhibit  D,  signed  by  a  Responsible  Officer.

6.3  TAXES.
     -----
     Borrower  will  make,  and cause each Subsidiary to make, timely payment of
all  material  federal,  state, and local taxes or assessments (other than taxes
and  assessments  which  Borrower  is  contesting  in  good faith, with adequate
reserves  maintained  in  accordance  with  GAAP)  and  will deliver to Bank, on
demand,  appropriate  certificates  attesting  to  the  payment.

6.4  DEPOSITS.
     --------

     Borrower will at all times maintain its primary operating accounts with the
Bank.  In  addition,  Borrower  will  at  all  times  maintain  on  deposit in a
segregated  securities  account with Bank or its Investment Products and Service
Division  a principal balance in a value equal to at least 110% of the principal
portion  of  the  Obligations plus all requested Credit Extensions, the value of
such  account  to  be  marked  to market on a monthly basis. The balance in such
account  must  be  invested  in a manner consistent with the Investment Policies
approved  by  Borrower's  Board  of Directors dated April 28, 2000, or in mutual
funds  offered  by  Bank  or  one  of  its  Affiliates.

6.5  FURTHER  ASSURANCES.
     -------------------

     Borrower  will execute all further instruments and take all further actions
as  Bank  reasonably  requests  to  perfect  or  continue  Bank's first priority
security  interest  in  the  Collateral  and  to  effect  the  purposes  of this
Agreement.

7.   NEGATIVE  COVENANTS.

     For  so long as Bank has an obligation to lend or there are any outstanding
Obligations,  Borrower  will not do any of the following to the extent that such
actions  impair  Bank's  Lien  on  the Collateral unless Borrower obtains Bank's
prior  written  consent:

7.1  DISPOSITIONS.
     ------------

     Borrower  will  not  convey,  sell, lease, transfer or otherwise dispose of
(collectively  "Transfer"),  all or any part of its business or property, except
for  Transfers  (i)  of  Inventory  in  the ordinary course of business, (ii) of
licenses and similar arrangements for the use of the property of Borrower or its
Subsidiaries  in  the  ordinary  course  of  business,  or  (iii) of worn-out or
obsolete  Equipment.

7.2  CHANGES  IN  BUSINESS,  OWNERSHIP,  MANAGEMENT  OR  BUSINESS  LOCATIONS.
     ------------------------------------------------------------------------

     Borrower will not, without the prior written consent of Bank, engage in any
business  other  than  the  businesses  currently  engaged  in  by  Borrower  or
businesses  reasonably  related  thereto. Borrower will not, without at least 30
days  prior  written  notice  to  Bank,  relocate  its  chief  executive office.

7.3  INDEBTEDNESS.
     ------------

     Borrower  will not create, incur, assume or be liable for any Indebtedness,
or  permit  any  Subsidiary  to  do  so,  other  than  Permitted  Indebtedness.

7.4  ENCUMBRANCES.
     ------------

     Borrower  will  not  create, incur or allow to exist any Lien on any of its
properties,  or assign or convey any right to receive income (including the sale
of  any  Accounts),  or  permit  any  of  its  Subsidiaries to do so, except for
Permitted  Liens,  or  permit  any  Collateral  not  to  be subject to the first
priority  security  interest herein granted to Bank, subject to Permitted Liens.

7.5  DISTRIBUTIONS;  INVESTMENTS.
     ---------------------------

     Borrower  will  not  directly  or  indirectly pay any dividends or make any
distribution  or  payment  related to, or redeem, retire or purchase any of, its
capital  stock,  except for (i) dividends and distributions consisting solely of
the  capital  stock  of  Borrower  and  (ii)  repurchases  of  stock from former
employees  or  directors  of  Borrower  under the terms of applicable repurchase
agreements  or pursuant to Borrower's employee stock option plans as approved by
Borrower's  board  of  directors.

7.6  TRANSACTIONS  WITH  AFFILIATES.
     ------------------------------

     Borrower  will not directly or indirectly enter into or permit any material
transaction  with  any  Affiliate,  except transactions that are in the ordinary
course of Borrower's business, on terms less favorable to Borrower than would be
obtained  in  an  arm's  length  transaction  with  a  non-affiliated  Person.

7.7  SUBORDINATED  DEBT.
     -------------------

     Borrower  will  not  make  or  permit  any payment on any Subordinated Debt
except  under the express terms of the Subordinated Debt, or amend any provision
in  any document relating to the Subordinated Debt, without Bank's prior written
consent.

7.8  COMPLIANCE.
     ----------

     Borrower will not become an "investment company" or a company controlled by
an  "investment company," under the Investment Company Act of 1940, or undertake
as  one  of its material activities extending credit to purchase or carry margin
stock,  or  use  the  proceeds of any Credit Extension for that purpose; fail to
meet  the  minimum  funding  requirements of ERISA, permit a Reportable Event or
Prohibited  Transaction  (as defined in ERISA) to occur; fail to comply with the
Federal  Fair Labor Standards Act or violate any other law or regulation, if the
violation  could  reasonably  be  expected  to have a material adverse effect on
Borrower's  business  or operations (or the business or operations of Guarantor)
or  would  reasonably  be expected to cause a Material Adverse Change, or permit
any  of  its  Subsidiaries  to  do  so.

8.   EVENTS  OF  DEFAULT.

8.1  PAYMENT  DEFAULT.
     ----------------

     Borrower  fails  to  pay  any of the Obligations within three Business Days
after  their due date. During the three-Business Day period, the failure to cure
the default is not itself an Event of Default (but Bank shall have no obligation
to  make  a  Credit  Extension  during  the  three-Business  Day  period).

8.2  COVENANT  DEFAULT.
     -----------------
     (a)  Borrower  fails  to  perform  any obligation under Section 6.4 of this
Agreement,  or  violates any of the covenants in Article 7 of this Agreement, or

     (b)  Borrower  fails  or  neglects  to  perform,  keep or observe any other
material term, provision, condition, covenant or agreement in this Agreement, in
any  other  Loan  Documents  or in any other present or future agreement between
Borrower  and  Bank  and,  as  to  any default under such other term, provision,
condition,  agreement  or  covenant  that  can  be cured, has failed to cure the
default  within  ten  (10) days after the occurrence thereof; provided, however,
that if the default cannot by its nature be cured within the ten-day period, and
such  default  is  likely  to be cured within a reasonable time thereafter, then
Borrower shall have an additional reasonable time period (which shall not in any
case exceed ten additional days) to cure such default. During the ten-day period
and  (if  applicable)  the  additional  ten-day  period, the failure to cure the
default  is not itself an Event of Default (but Bank shall have no obligation to
make  a  Credit  Extension  during  such  periods).

8.3  MATERIAL  ADVERSE  CHANGE.
     -------------------------

     There  occurs  (i) a material adverse change in the business, operations or
condition  (financial  or otherwise) of the Borrower, (ii) a material impairment
of  the  prospect  of  repayment  of  any portion of the Obligations, or (iii) a
material  impairment  to  the value of, or the priority of Bank's Lien upon, the
Collateral  (or  any  material  portion  thereof).

8.4  ATTACHMENT.
     ----------

     Any material portion of Borrower's assets is attached, seized or levied on,
or  comes  into possession of a trustee or receiver, and the attachment, seizure
or  levy  is  not  removed,  or  the  possession by a trustee or receiver is not
terminated,  in  ten  days;  or Borrower is enjoined, restrained or prevented by
court  order  from conducting a material part of its respective businesses; or a
judgment  or  other  claim  becomes  a  Lien on a material portion of Borrower's
assets;  or  a  notice  of  lien,  levy  or  assessment  is filed against any of
Borrower's  assets  by  any government agency and not paid within ten days after
Borrower  receives  notice thereof. None of the foregoing is an Event of Default
if  stayed  or  if  a bond is posted pending contest by Borrower (but Bank shall
have no obligation to make a Credit Extension during such stay period or pending
contest).

8.5  INSOLVENCY.
     ----------

     Borrower  becomes  insolvent  or  begins  an  Insolvency  Proceeding, or an
Insolvency  Proceeding  is begun against Borrower and is not dismissed or stayed
within  30  days  (but  Bank shall have no obligation to make a Credit Extension
before  any  Insolvency  Proceeding  is  dismissed).

8.6  OTHER  AGREEMENTS.
     -----------------

     There is a default in any agreement between Borrower and a third party that
gives  the  third  party  the  right  to  accelerate  any Indebtedness exceeding
$1,000,000.

8.7  JUDGMENTS.
     ---------

     A  money  judgment(s)  in  the aggregate of at least $5,000,000 is rendered
against  Borrower  and  is unsatisfied and unstayed for ten days (but Bank shall
have  no  obligation to make a Credit Extension before the judgment is stayed or
satisfied).

8.8  MISREPRESENTATIONS.
     ------------------

     Borrower,  or  any  Person  acting  for  Borrower,  makes  any  material
misrepresentation  or  material  misstatement  now  or  later in any warranty or
representation in this Agreement or in any writing delivered to Bank or in order
to  induce  Bank  to  enter  this  Agreement  or  any  Loan  Document.

9.   BANK'S  RIGHTS  AND  REMEDIES.

9.1  RIGHTS  AND  REMEDIES.
     ---------------------

     When  an  Event  of Default occurs and any period for cure has expired Bank
may,  without  notice  or  demand,  do  any  or  all  of  the  following:

     (a) Declare all Obligations immediately due and payable (but if an Event of
Default  described in Section 8.5 occurs all Obligations are immediately due and
payable  without  any  action  by  Bank);

     (b)  Stop  advancing money or extending credit for Borrower's benefit under
this  Agreement  or  under  any  other  agreement  between  Borrower  and  Bank;

     (c)  Make  any  payments  and  do any acts that Bank considers necessary or
reasonable  to  protect  its  security  interest  in  the  Collateral;

     (d)  Apply  to  the  Obligations,  after first applying the balances of the
segregated  investment  accounts  thereto,  any  (i)  balances  and  deposits of
Borrower  that  Bank  holds,  and  (ii) amounts held by Bank owing to or for the
credit  or  the  account  of  Borrower;  and

     (e)  Dispose  of  the  Collateral  according  to  the  Code.

9.2  POWER  OF  ATTORNEY.
     -------------------

     Borrower  irrevocably  appoints  and  constitutes  Bank  as  its  lawful
attorney-in-fact,  with full power and in the name of Borrower, to do all of the
following  upon  the  occurrence  and  continuation  of an Event of Default: (i)
endorse Borrower's name on any checks or other forms of payment or security; and
(ii)  transfer the Collateral into the name of Bank or a third party as the Code
permits.  Notwithstanding the foregoing, Bank may exercise the power of attorney
to  sign  Borrower's  name on any documents necessary to perfect or continue the
perfection  of  any  security interest regardless of whether an Event of Default
has  occurred.  Bank's  appointment  as  Borrower's attorney-in-fact, and all of
Bank's rights and powers, are coupled with an interest and irrevocable until all
Obligations  have  been  fully  repaid  and  performed  and Bank's obligation to
provide  Credit  Extensions  terminates.

9.3  BANK  EXPENSES.
     --------------

     If  Borrower  fails  to  pay  any  amount  or furnish any required proof of
payment  to third persons, Bank may make all or part of the payment. Any amounts
paid by Bank are Bank Expenses and immediately due and payable, bearing interest
at  the  then-applicable rate and secured by the Collateral. No payments by Bank
are  deemed  an  agreement  to make similar payments in the future or constitute
Bank's  waiver  of  any  Event  of  Default.

9.4  BANK'S  LIABILITY  FOR  COLLATERAL.
     ----------------------------------

     If  Bank  complies with reasonable banking practices and the Code, it shall
not  be  liable  for:  (i)  the  safekeeping of the Collateral; (ii) any loss or
damage  to  the Collateral; (iii) any diminution in the value of the Collateral;
or  (iv)  any  act  or  default  of  any carrier, warehouseman, bailee, or other
person.  Borrower  bears  all  risk  of  loss,  damage  or  destruction  of  the
Collateral.

9.5  REMEDIES  CUMULATIVE.
     --------------------

     Bank's  rights  and remedies under this Agreement, the other Loan Documents
and  all  other  agreements  are  cumulative.  Bank  has all rights and remedies
provided  under  the Code, by law and in equity. Bank's exercise of one right or
remedy  is  not  an election, and Bank's waiver of any Event of Default is not a
continuing  waiver.  Bank's  delay is not a waiver, election or acquiescence. No
waiver  is  effective  unless signed by Bank, and then is only effective for the
specific  instance  and  purpose  for  which  it  was  given.

9.6  DEMAND  WAIVER.
     --------------

     Borrower  waives  demand,  notice of default or dishonor, notice of payment
and  nonpayment,  notice  of  any  default,  nonpayment  at  maturity,  release,
compromise,  settlement,  extension  or  renewal  of  accounts,  documents,
instruments,  chattel  paper  and  guaranties  held by Bank on which Borrower is
liable.

10.  NOTICES.

     All  notices  or  demands  by  any  party about this Agreement or any other
related  agreement  must be in writing and be personally delivered or sent by an
overnight  delivery service, by certified mail, (postage prepaid, return receipt
requested)  or  by  telefacsimile to the addresses set forth at the beginning of
this  Agreement. A party may change its notice address by giving the other party
written  notice  thereof.

11.  CHOICE  OF  LAW,  VENUE  AND  JURY  TRIAL  WAIVER.

     California  law  governs the Loan Documents without regard to principles of
conflicts of law. Borrower and Bank each submit to the exclusive jurisdiction of
the  State  and  Federal  courts  in  Santa  Clara  County,  California.

BORROWER  AND  BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE
OF  ACTION  ARISING  OUT  OF  ANY  OF  THE  LOAN  DOCUMENTS  OR ANY CONTEMPLATED
TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS
WAIVER  IS  A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT.
EACH  PARTY  HAS  REVIEWED  THIS  WAIVER  WITH  ITS  COUNSEL.

12.  GENERAL  PROVISIONS.

12.1 SUCCESSORS  AND  ASSIGNS.
     ------------------------

     This Agreement binds and is for the benefit of the successors and permitted
assigns  of  each  party.  Borrower  may not assign this Agreement or any rights
under  it without Bank's prior written consent, which may be granted or withheld
in  Bank's  discretion.  Bank has the right, without the consent of or notice to
Borrower,  to  sell,  transfer,  negotiate or grant participations in all or any
part  of, or any interest in, Bank's obligations, rights and benefits under this
Agreement.

12.2 INDEMNIFICATION.
     ---------------

     Borrower  will  indemnify,  defend and hold harmless Bank and its officers,
employees,  and  agents  against:  (i)  all  obligations,  demands,  claims, and
liabilities  asserted  by  any  other  party in connection with the transactions
contemplated  by  the  Loan  Documents;  and  (ii)  all losses and Bank Expenses
incurred  or  paid  by  Bank  from,  following  or consequential to transactions
between  Bank  and  Borrower (including reasonable attorneys fees and expenses),
except  in  each  case  for  losses caused by Bank's gross negligence or willful
misconduct.

12.3 TIME  OF  ESSENCE.
     -----------------

     Time  is  of  the  essence  for  the performance of all obligations in this
Agreement.

12.4 SEVERABILITY  OF  PROVISION.
     ---------------------------

     Each provision of this Agreement is severable from every other provision in
determining  the  enforceability  of  any  provision.

12.5 AMENDMENTS  IN  WRITING,  INTEGRATION.
     -------------------------------------

     All  amendments to this Agreement must be in writing and signed by Borrower
and  Bank.  This  Agreement  represents  the entire agreement about this subject
matter,  and  supersedes prior negotiations or agreements. All prior agreements,
understandings, representations, warranties and negotiations between the parties
about  the  subject  matter  of this Agreement merge into this Agreement and the
other  Loan  Documents.

12.6 COUNTERPARTS.
     ------------

     This  Agreement  may  be  executed  in  any  number  of counterparts and by
different  parties  on  separate  counterparts, each of which, when executed and
delivered,  are  an  original,  and all of which, taken together, constitute one
Agreement.

12.7 SURVIVAL.
     --------

     All  covenants,  representations  and  warranties  made  in  this Agreement
continue in full force while any Obligations remain outstanding. The obligations
of Borrower in Section 12.2 to indemnify Bank will survive until all statutes of
limitations  for  actions  that  may  be  brought  against  Bank  have  run.

12.8 CONFIDENTIALITY.
     ---------------

     In  handling  any  confidential  information,  Bank  will exercise the same
degree  of  care  that  it  exercises  for  its own proprietary information, and
disclosure  of  information  may  be made by Bank: (i) to Bank's subsidiaries or
affiliates  in connection with their business with Borrower; (ii) to prospective
transferees  or  purchasers  of  any  interest  in the Loan Documents (provided,
however,  Bank  shall  use  commercially  reasonable  efforts  in obtaining such
prospective  transferee or purchasers agreement of the terms of this provision);
(iii)  as required by law, regulation, subpoena or other order; (iv) as required
in  connection  with  Bank's  examination  or  audit;  and (v) as Bank considers
appropriate  in  exercising  remedies  under  this  Agreement.  Confidential
information  does  not  include  information  that  either: (i) is in the public
domain  or  in  Bank's possession when disclosed to Bank, or becomes part of the
public  domain  after  disclosure  to  Bank through no fault of Bank; or (ii) is
disclosed  to  Bank by a third party, if Bank does not know that the third party
is  prohibited  from  disclosing  the  information.

12.9 ATTORNEYS'  FEES,  COSTS  AND  EXPENSES.
     ---------------------------------------

     In  any  action  or proceeding between Borrower and Bank arising out of the
Loan  Documents, the prevailing party will be entitled to recover its reasonable
attorneys' fees and other reasonable costs and expenses incurred, in addition to
any  other  relief  to  which  it  may  be  entitled.

13.  DEFINITIONS.

     In  this  Agreement:

     "AFFILIATE"  of  a  Person  is a Person that owns or directly or indirectly
controls  the  Person,  any Person that controls or is controlled by or is under
common  control  with  the  Person,  and  each of that Person's senior executive
officers,  directors,  partners  and, for any Person that is a limited liability
company,  that  Person's  managers  and  members.

     "BANK  EXPENSES"  are  all audit fees and expenses and reasonable costs and
expenses  (including  reasonable  attorneys'  fees  and expenses) for preparing,
negotiating,  administering,  defending  and  enforcing  the  Loan  Documents
(including  appeals  and  Insolvency  Proceedings).

     "BASIC RATE" is, as to each Equipment Advance, the Prime Rate, as that rate
shall  change  from  time  to  time.

     "BORROWER'S  BOOKS"  are  all  of  Borrower's  books and records, including
ledgers,  records  regarding  Borrower's  assets or liabilities, the Collateral,
business operations or financial condition and all computer programs or discs or
any  equipment  containing  the  information.

     "BUSINESS  DAY"  is  any day that is not a Saturday, Sunday or other day on
which  the  Bank  is  closed.

     "CLOSING  DATE"  is  the  date  of  this  Agreement.

     "CODE"  is  the  Uniform  Commercial  Code,  as  applicable.

     "COLLATERAL"  is  the  property  described  on  Exhibit  A.

     "COMMITTED EQUIPMENT LINE" is the principal sum of $16,000,000 of Equipment
Advances.

     "COMMITMENT  TERMINATION  DATE"  is the one-year anniversary of the Closing
Date.

     "CONTINGENT  OBLIGATION"  is,  for  any  Person,  any  direct  or  indirect
liability,  contingent  or  not, of that Person for (i) any indebtedness, lease,
dividend,  letter of credit or other obligation of another such as an obligation
directly  or  indirectly  guaranteed, endorsed, co-made, discounted or sold with
recourse  by  that  Person,  or  for which that Person is directly or indirectly
liable;  (ii)  any  obligations for undrawn letters of credit for the account of
that  Person;  and  (iii)  all  obligations  from any interest rate, currency or
commodity  swap  agreement,  interest  rate  cap  or  collar agreement, or other
agreement  or  arrangement designated to protect a Person against fluctuation in
interest  rates,  currency  exchange  rates or commodity prices; but "Contingent
Obligation"  does  not  include endorsements in the ordinary course of business.
The  amount of a Contingent Obligation is the stated or determined amount of the
primary  obligation  for  which  the  Contingent  Obligation  is made or, if not
determinable,  the maximum reasonably anticipated liability for it determined by
the  Person  in  good  faith;  but  the amount may not exceed the maximum of the
obligations  under  the  guarantee  or  other  support  arrangement.

     "CREDIT  EXTENSION"  is  each  Equipment  Advance or any other extension of
credit  made  by  Bank  to  Borrower  or  for  Borrower's  benefit.

     "DOLLARS"  and  "$"  is  United  States  dollars.

     "ELIGIBLE  EQUIPMENT"  is  new  or used general purpose computer equipment,
office  equipment,  test  and  laboratory  equipment and furnishings, as well as
Other  Equipment.

     "EQUIPMENT"  is  all  present  and  future  machinery,  equipment,  tenant
improvements,  furniture,  fixtures,  vehicles,  tools, parts and attachments in
which  Borrower  has  any  interest.

     "EQUIPMENT  ADVANCE"  is  defined  in  Section  2.1.1.

     "EQUIPMENT LOAN AMOUNT" is the amount of each Equipment Advance. "ERISA" is
the  Employment  Retirement  Income  Security  Act of 1974, and its regulations.

     "EVENT  OF  DEFAULT"  is the occurrence of any event described in Article 8
but  does  not  include  any  cure  period  provided  therein.

     "FINANCED  EQUIPMENT"  is  defined  in  the  Loan  Supplement.

     "FUNDING  DATE"  is  a  date on which an Equipment Advance is made to or on
account  of  Borrower.

     "GAAP"  is  generally  accepted accounting principles, consistently applied
over  the  period(s)  in  question.

     "INDEBTEDNESS" is (a) indebtedness for borrowed money or the deferred price
of  property or services, such as reimbursement and other obligations for surety
bonds  and  letters  of  credit,  (b)  obligations  evidenced  by  notes, bonds,
debentures  or  similar  instruments,  (c)  capital  lease  obligations  and (d)
Contingent  Obligations.

     "INITIAL  EQUIPMENT  ADVANCE"  is  the  first  Equipment  Advance under the
Committed  Equipment  Line.

     "INSOLVENCY PROCEEDINGS" are proceedings by or against any Person under the
United  States  Bankruptcy  Code  or  any  other  bankruptcy  or insolvency law,
including  assignments  for  the  benefit of creditors, compositions, extensions
generally with its creditors, or proceedings seeking reorganization, arrangement
or  other  relief.

     "INVESTMENT"  is  any  beneficial  ownership  (including stock, partnership
interest  or  other  securities)  of any Person, or any loan, advance or capital
contribution  to  any  Person.

     "LIEN"  is  a  mortgage,  lien,  deed  of  trust,  charge, pledge, security
interest  or  other  encumbrance.

     "LOAN  DOCUMENTS" are, collectively, this Agreement, any note or notes, and
any  other present or future agreement between Borrower to or for the benefit of
Bank  in  connection  with this Agreement, all as amended, extended or restated.

     "LOAN  FEE"  is  an  amount  equal  to  $80,000.

     "LOAN  SUPPLEMENT"  is  attached  as  Exhibit  C.
                                           ----------

     "MATERIAL  ADVERSE  CHANGE"  is  described  in  Section  8.3.

     "MATURITY  DATE"  is,  as  to  each  Equipment Advance, the last day of the
Repayment  Period  for  such  Equipment  Advance  or,  if  earlier,  the date of
acceleration  of  the  Equipment  Advance by Bank following an Event of Default.

     "OBLIGATIONS"  are  debts,  principal,  interest,  Bank  Expenses and other
amounts  that  Borrower  owes  to  Bank  now or later, including cash management
services,  letters  of  credit  and  foreign  exchange  contracts  (if  any) and
including  interest  accruing  after  Insolvency  Proceedings  begin, and debts,
liabilities  or  obligations  of  Borrower  assigned  to  Bank.

     "ORIGINAL  STATED  COST"  is  (i), the original cost to the Borrower of the
item  of  new  Eligible  Equipment net of any and all freight, installation, tax
(except  to  the  extent Eligible Equipment constitutes Other Equipment) or (ii)
the fair market value assigned to such item of used Eligible Equipment by mutual
agreement  of  Borrower  and Bank at the time of making of an Equipment Advance.

     "OTHER  EQUIPMENT" is leasehold improvements, taxes, freight, installation,
intangible  property  such as computer software and software licenses, equipment
specifically  designed  or manufactured for Borrower, other intangible property,
limited  use  property  and  other  similar  property.

     "OVERADVANCE"  is  described  in  Section  2.2.

     "PERMITTED  INDEBTEDNESS"  is:

     (a)  Borrower's indebtedness to Bank under this Agreement or any other Loan
Document;

     (b)  Indebtedness  existing  on the Closing Date that is acceptable to Bank
and  shown  on  the  Schedules;

     (c)  Subordinated  Debt;

     (d)  Indebtedness  to  trade  creditors  incurred in the ordinary course of
business;  and

     (e)  Indebtedness  of Borrower to any Subsidiary and Contingent Obligations
of  any  Subsidiary  with  respect to obligations of Borrower (provided that the
primary  obligations  are  not  prohibited  hereby),  and  Indebtedness  of  any
Subsidiary  to any other Subsidiary and Contingent Obligations of any Subsidiary
with  respect  to obligations of any other Subsidiary (provided that the primary
obligations  are  not  prohibited  by);

     (f) other Indebtedness not otherwise permitted by Section 7.4 not exceeding
$1,000,000  in  the  aggregate  outstanding  at  any  time;  and

     (g)  Indebtedness  secured  by  Permitted  Liens.

     "PERMITTED  INVESTMENTS"  are:

     (a)  Investments  existing  on the Closing Date that are acceptable to Bank
and  shown  on  the  Schedules;

     (b)  (i) marketable direct obligations issued or unconditionally guaranteed
by  the  United States or its agency or any State maturing within two years from
its  acquisition, (ii) commercial paper maturing no more than one year after its
creation and having the highest rating from either Standard & Poor's Corporation
or  Moody's  Investors  Service,  Inc., and (iii) Bank's certificates of deposit
issued  maturing  no  more  than  one  year  after  issue;

     (c)  Investments  consisting  of  Borrower's  accounts  receivable  in  the
ordinary  course  of  business;

     (d)  Investments  consisting  of loans to employees, officers or directors;

     (e)  other Investments in accordance with Borrower's investment policies as
approved  in  good  faith  by  Borrower's  board  of  directors;  and

     (f) checking, savings, money market and investment accounts with Bank or an
Affiliate  of  Bank.

     "PERMITTED  LIENS"  are:

     (a)  Liens  existing  on  the  Closing Date that are acceptable to Bank and
shown  on the Schedules or arising under this Agreement or other Loan Documents;

     (b)  Liens  for  taxes,  fees,  assessments  or other government charges or
levies,  either  not  delinquent  or being contested in good faith and for which
Borrower maintains adequate reserves on its Books, if they have no priority over
any  of  Bank's  security  interests;

     (c)  purchase  money Liens (i) on Equipment acquired or held by Borrower or
its  Subsidiaries  incurred  for  financing the acquisition of the Equipment, or
(ii)  existing  on  equipment  when  acquired,  if  the  Lien is confined to the
property  and  improvements and the proceeds of the equipment, provided that any
such  lien  pertaining  to  Eligible Equipment that is financed by the Equipment
Advances  must  be  in  favor  of  Bank;

     (d)  licenses  or  sublicenses granted in the ordinary course of Borrower's
business  and  any  interest  or  title  of  a  licensor or under any license or
sublicense,  if  the  licenses  and  sublicenses permit granting Bank a security
interest;

     (e)  leases  or  subleases  granted  in  the  ordinary course of Borrower's
business,  including  in  connection  with  Borrower's leased premises or leased
property;

     (f)  Liens  in  favor  of  Bank  hereunder;

     (g)  Liens  arising from judgments, decrees or attachments in circumstances
not  constituting  an  Event  of  Default  under  Section  8.7;  and

     (h)  Liens  incurred  in  the  extension,  renewal  or  refinancing  of the
indebtedness  secured  by Liens described in (a) through (c), but any extension,
renewal  or  replacement  Lien must be limited to the property encumbered by the
existing  Lien  and  the principal amount of the indebtedness so secured may not
increase.

     "PERSON"  is  any  individual,  sole  proprietorship,  partnership, limited
liability  company,  joint  venture,  company association, trust, unincorporated
organization, association, corporation, institution, public benefit corporation,
firm,  joint  stock  company,  estate,  entity  or  government  agency.

     "PRIME  RATE" is Bank's most recently announced "prime rate," even if it is
not  the  lowest  rate  at  which  Bank makes loans or otherwise extends credit.

     "REPAYMENT  PERIOD"  as  to  each  Equipment  Advance  is  48  months.

     "RESPONSIBLE  OFFICER"  is  each  of  the  Chief  Executive  Officer,  the
President,  the  Chief  Financial  Officer  and  the  Controller  of  Borrower.

     "SCHEDULED  PAYMENTS"  is  described  in  Section  2.3.1(a).

     "SCHEDULES"  are  the  attached  schedules  of  exceptions.

     "SUBORDINATED  DEBT"  is  debt incurred by Borrower that is subordinated to
Borrower's  Indebtedness  owed  to  Bank  and  that  is  reflected  in a written
agreement  in  a  manner  and  form  acceptable  to Bank and approved by Bank in
writing.

     "SUBORDINATION  AGREEMENT"  shall  mean  one or more agreements in favor of
Bank  as  senior  creditor  relating  to  Subordinated  Debt.

     "SUBSIDIARY"  is,  for Borrower, any business entity of which more than 20%
of  the  voting stock or other equity interests is owned or controlled, directly
or  indirectly,  by  Borrower  or  one  or  more  Affiliates  of  Borrower.

     IN  WITNESS  WHEREOF,  each  of  the  parties  hereto  has  caused its duly
authorized  representative  to  execute  and  deliver this Agreement on the date
first  set  forth  above.

BANK:                                        BORROWER:
SILICON  VALLEY  BANK,                       EXELIXIS,  INC.,
a  California-chartered  bank                a  Delaware  corporation.

By: /s/ D. Edward Wohlleb                    By: /s/ Glen Y. Sato
    ------------------------------               ------------------------------
Name: D. Edward Wohlleb                      Name: Glen Y. Sato
      ----------------------------                 ----------------------------
Title: Vice President                        Title: CFO & VP Legal Affairs
       ---------------------------                  ---------------------------

                                    EXHIBIT A
                                   ----------

     The  Collateral  consists of all of Borrower's right, title and interest in
and  to  the  following:

     All documents, cash, deposit accounts, securities, securities entitlements,
securities  accounts,  investment property, financial assets, letters of credit,
certificates  of  deposit and instruments held in segregated investment accounts
with  Bank or an affiliate of Bank, whether now owned or hereafter acquired, and
all  proceeds  of  any of the foregoing, and all of Borrower's Books relating to
the  foregoing.



                                    EXHIBIT B
                                    ---------
LOAN  PAYMENT/ADVANCE  REQUEST  FORM


FAX  TO:                                                     DATE:
          --------------------------                               ------------
- -------------------------------------------------------------------------------
 Loan  Payment:
- -
                                 EXELIXIS, INC.
From  Account  #                              To  Account  #
                 ----------------------                      ------------------
                  (Deposit  Account  #)                        (Loan Account #)

Principal  $                     and/or  Interest  $
            ---------------------                   ----------------------------
All  Borrower's representation and warranties in the Loan and Security Agreement
are  true,  correct  and complete in all material respects to on the date of the
telephone  transfer  request  for  and  advance,  but  those representations and
warranties  expressly  referring  to  another  date  shall  be true, correct and
complete  in  all  material  respects  as  of  the  date:

AUTHORIZED  SIGNATURE:                           Phone  Number:
                      ---------------------------              --------------

- --------------------------------------------------------------------------------

 LOAN  ADVANCE:
- -

COMPLETE  OUTGOING  WIRE  REQUEST SECTION BELOW IF ALL OR A PORTION OF THE FUNDS
FROM  THIS  LOAN  ADVANCE  ARE  FOR  AN  OUTGOING  WIRE.

From  Account  #                              To  Account  #
                 ----------------------                      ------------------
                  (Deposit  Account  #)                        (Loan Account #)

Amount  of  Revolving  Advance  $
                                 ---------------------------------

All  Borrower's representation and warranties in the Loan and Security Agreement
are  true,  correct  and complete in all material respects to on the date of the
telephone  transfer  request  for  and  advance,  but  those representations and
warranties  expressly  referring  to  another  date  shall  be true, correct and
complete  in  all  material  respects  as  of  the  date:


AUTHORIZED  SIGNATURE:                           Phone  Number:
                      ---------------------------              --------------

- --------------------------------------------------------------------------------

OUTGOING  WIRE  REQUEST
COMPLETE ONLY IF ALL OR A PORTION OF FUNDS FROM THE LOAN ADVANCE ABOVE ARE TO BE
WIRED.
Deadline  for  same  day  processing  is  12:00  p.m.,  P.T.

Beneficiary  Name:                         Amount  of  Wire:  $
                  -----------------------                      ----------------
Beneficiary  Bank:                         Account  Number:
                  -----------------------                      ----------------

City  and  Sate:
                -------------------------
Beneficiary  Bank  Transit  (ABA)  #:
                                     -- -- -- -- -- - --
Beneficiary Bank Code  (Swift,  Sort,  Chip,  etc.):
                                                     --------------------------

                          (FOR INTERNATIONAL WIRE ONLY)

Intermediary  Bank:                          Transit  (ABA)  #:
                   -------------------------                   ----------------
For  Further  Credit  to:
                         ------------------------------------------------------
Special  Instruction:
                      ---------------------------------------------------------
By  signing  below,  I  (we)  acknowledge and agree that my (our) funds transfer
request  shall  be  processed  in  accordance  with and subject to the terms and
conditions  set  forth  in the agreements(s) covering funds transfer service(s),
which  agreements(s)  were  previously  received  and  executed  by  me  (us).

Authorized  Signature:                    2nd Signature (If Required):
                      -------------------                             ---------
Print  Name/Title:                        Print  Name/Title:
                  ----------------------                     ------------------
Telephone  #                              Telephone  #
             ----------------------------                -- -------------------
- -------------------------------------------------------------------------------


     EXHIBIT  C
     ----------
                        FORM OF LOAN AGREEMENT SUPPLEMENT
                        ---------------------------------

                        LOAN AGREEMENT SUPPLEMENT No. [ ]

LOAN  AGREEMENT  SUPPLEMENT No. [ ], dated        , 200  ("Supplement"), to the
                                           --------    --
Loan  and  Security  Agreement dated as of May 22, 2002 (the "Loan Agreement) by
and  between  the  undersigned  ("Borrower"),  and Silicon Valley Bank ("Bank").
Capitalized terms used herein but not otherwise defined herein are used with the
respective  meanings  given  to  such  terms  in  the  Loan  Agreement. The Loan
Agreement  is  hereby  incorporated  by reference herein and is hereby ratified,
approved  and  confirmed.

Borrower  hereby  requests  an  Equipment  Advance  in  the  amount  of
$                    in  order  to  finance  the Eligible Equipment set forth on
 -------------------
Annex  A  hereto.  Annex  A (Eligible Equipment Schedule) and Annex B (Equipment
Advance  Terms  Schedule)  are  attached  hereto and incorporated herein for all
purposes.

The  proceeds  of the Loan should be transferred to Borrower's account with Bank
set  forth  below:

Bank  Name:     Silicon  Valley  Bank

Account  No.:
               ------------------------

Borrower hereby certifies that (i) the foregoing information is true and correct
and authorizes Bank to endorse in its respective books and records the principal
amount  set  forth  in  the  Equipment  Advance  Terms  Schedule;  (ii)  the
representations  and  warranties made by Borrower in the Loan Agreement are true
and  correct  in  all  material respects on the date hereof and will be true and
correct  in  all  material  respects on such Funding Date; and (iii) no Event of
Default  has  occurred  and  is  continuing  under  the  Loan  Agreement.  This
Supplement  may  be executed by Borrower and Bank in separate counterparts, each
of  which  when  so  executed  and  delivered shall be an original, but all such
counterparts  shall  together  constitute  but  one  and  the  same  instrument.

This  Supplement  is  delivered  as  of  this  day and year first above written.

SILICON  VALLEY  BANK,                          EXELIXIS,  INC.,
a  California-chartered  bank                   a  Delaware  corporation


By:                                             By:
   -------------------------                       -------------------------
  Name:                                           Name:
       ---------------------                           ---------------------
  Title:                                          Title:
        --------------------                            --------------------



                                     Annex A
                                     -------
                           ELIGIBLE EQUIPMENT SCHEDULE
                           ---------------------------
     The  Eligible  Equipment  being  financed  with the Equipment Advance as to
which  this  Loan  Agreement  Supplement  is  being  executed  is  listed below.

Description of Equipment                         Total Costs
- ------------------------                         -----------


                                     Annex B
                                     -------

                   EQUIPMENT ADVANCE TERMS SCHEDULE #________

Funding  Date:,           ,200
               -----------    --

Principal  Amount  of  Equipment  Advance  $
                                            --------------

Basic  Rate:  Prime  Rate  (floating)

Scheduled  Payment  Dates  and  Principal  Amounts*:

     Forty-eight (48) principal payments of $        due monthly in arrears from
                                             -------
           through          .
- ----------         ---------

Maturity  Date:
               -----------




                                    EXHIBIT D
                                    ---------
                             COMPLIANCE CERTIFICATE
                             ----------------------

TO:      SILICON  VALLEY  BANK
FROM:    EXELIXIS,  INC.
DATED:
         --------------------

     The undersigned authorized officer of Exelixis, Inc. ("Borrower") certifies
that under the terms and conditions of the Loan and Security Agreement dated May
22,  2002  between  Borrower  and  Bank  (the  "Agreement"),  (i) Borrower is in
complete compliance for the period ending on the date first set forth above with
all  required  covenants  except as noted below and (ii) all representations and
warranties  in  the  Agreement  are true and correct in all material respects on
this  date.  Attached  are  the required documents supporting the certification.
The  Officer  certifies  that  these  are  prepared in accordance with Generally
Accepted  Accounting  Principles  (GAAP) consistently applied from one period to
the  next  except  as  explained  in  an  accompanying letter or footnotes.  The
Officer  acknowledges that no borrowings may be requested at any time or date of
determination  that  Borrower  is not in compliance with any of the terms of the
Agreement,  and  that  compliance  is  determined  not  just  at  the  date this
certificate  is  delivered.

PLEASE  INDICATE  COMPLIANCE  STATUS BY CIRCLING YES/NO UNDER "COMPLIES" COLUMN.




  REPORTING COVENANTS                       REQUIRED                     COMPLIES
- ------------------------------------------  --------------------------  -------------
                                                                         
  Quarterly financial statements + CC. . .  Quarterly within 45 days    Yes       No
        after the end of each of first
        three quarters of each Fiscal Year
Annual audited financial statements + CC    Within 90 days of FYE       Yes       No
  Forms 10K and 10Q. . . . . . . . . . . .  Within 10 days of filing    Yes       No



COMMENTS  REGARDING  EXCEPTIONS:  See  Attached.

Sincerely,

EXELIXIS,  INC.,
a  Delaware  corporation


- --------------------------------------
SIGNATURE

- --------------------------------------
TITLE

- --------------------------------------
DATE

- --------------------------------------------------------------------------------

BANK USE ONLY

Received  by:
             ------------------------
              AUTHORIZED SIGNER

Date:
     --------------------------------

Verified:
         ----------------------------
              AUTHORIZED SIGNER

Date:
     --------------------------------

Compliance Status:          Yes   No