Filed by Endo Pharmaceuticals Holdings Inc. Pursuant to Rule 425 under the Securities Act of 1933 and deemed filed pursuant to Rule 14a-12 of the Securities Exchange Act of 1934 Subject Company: Algos Pharmaceutical Corporation Commission File No. 0-28844 The following is a description of a portion of a slide presentation that has been prepared for future presentation to affiliates of Kelso & Company. Endo Pharmaceuticals Inc. Kelso Conference May 2000 Algos Merger Endo Endo Pharmaceuticals Inc. Algos Algos is a leader in developing proprietary pain management products Algos products combine existing analgesics and anesthetics with NMDA-receptor antagonist drugs Endo Endo Pharmaceuticals Inc. Algos Merger On November 26, 1999 Endo announced that we entered into a definitive merger agreement with Algos Pharmaceuticals Initially 80%-20% Endo-Algos Possible ratios from 85%-15% to 60%-40% depending on: Timing of MorphiDex(R)approval Endo achieving a defined gross profit target in Fiscal 2000 Merger subject to Algos shareholder approval Collaboration agreement on Oxycodone Endo Endo Pharmaceuticals Inc. Merger Summary Carol A. Ammon named President and CEO and John W. Lyle named Chairman of the Board Endo in process of registering to become a public company on the Nasdaq ("ENDP") - Algos will merge with and into a subsidiary of Endo Series of warrants to be issued to address contingent nature of ownership ranges Merger anticipated to close late second quarter 2000 Endo Endo Pharmaceuticals Inc. Merger - Strategic Rationale Combined Company becomes a U.S. leader in pain management with brand equity and novel proprietary technology Marriage of established specialty pharmaceutical company with a broad technology development company Significant growth potential through: - Existing marketed products - Newly launched branded products - Pipeline of late stage development products Endo Endo Pharmaceuticals Inc. Merger- Strategic Rationale Focus on large, fast-growing Pain Management markets Accelerated market penetration of Algos' patented technology through existing Endo commercial capabilities Percocet(R) brand significantly enhanced with NMDA patented technology Endo Endo Pharmaceuticals Inc. Recent Algos Developments On August 2, 1999, Algos received a "non-approvable" letter from the FDA on its lead product MorphiDex(R) FDA meeting held December 1999 to resolve MorphiDex(R) NDA deficiencies Two additional large MorphiDex(R) post-operative pain studies underway MorphiDex(R) refiling preparation underway Endo Endo Pharmaceuticals Inc. Broad and Deep Portfolio Moderate Moderately Severe Severe -------- ----------------- ------ --------------------------------------> Existing Brands: Nubain(R) Percocet(R) 5.0, Percodan(R), Percolone(R), Numorphan(R) New Brands: Lidoderm(R) Percocet(R) 2.5 Percocet(R) 7.5, Percocet(R) 10 Zydone(R) 5, Zydone(R) 7.5, Zydone(R) 10 Pipeline Brands: EN3222 EN3223 Numorphan(R)IR and CR Patent Protected Brands HydrocoDex(TM) OxycoDex(TM) MorphiDex(R) EN3215 LidoDex(TM) NS NeuroDex(TM) EN3216 Endo Endo Pharmaceuticals Inc. On December 17, 1999, Algos Pharmaceutical Corporation filed a proxy statement/prospectus on Schedule 14A in connection with its proposed merger with Endo Pharmaceuticals Holdings Inc. Algos filed amendments to the proxy statement/prospectus on Schedule 14A with the Securities and Exchange Commission on March 3 and April 13, 2000. WE URGE INVESTORS TO READ THE PROXY STATEMENT/PROSPECTUS AND ANY OTHER RELEVANT DOCUMENTS TO BE FILED WITH THE SEC, BECAUSE THEY CONTAIN IMPORTANT INFORMATION. Investors and stockholders may obtain a free copy of Amendment No. 2 to the proxy statement/prospectus on Schedule 14A and other documents filed by Algos with the SEC at the SEC's website at www.sec.gov. In addition, the proxy statement/prospectus and other documents filed with the SEC by Algos may be obtained for free from Algos by directing a request to Algos Pharmaceutical Corporation, 1333 Campus Parkway, Neptune, New Jersey 07753-6815, Attention: Investor Relations, Telephone: (732) 938-5959. Endo, Algos, their respective directors, executive officers and other employees and certain other persons may be soliciting proxies from Algos stockholders in favor of the merger. Information concerning the participants in the solicitation is included in Amendment No. 2 to the proxy statement/prospectus on Schedule 14A filed by Algos with the Commission on April 13, 2000.