EXHIBIT 4.1 A BRITISH COLUMBIA BUSINESS CORPORATIONS ACT COMPANY NUMBER SHARES ASPREVA PHARMACEUTICALS ****0********* ZQ 123456 *****0******** ******0******* *******0****** ********0***** THIS CERTIFIES THAT CUSIP 04538T 10 9 ** SPECIMEN ** ISIN CA 04538T1093 SEE REVERSE FOR CERTAIN DEFINITIONS is the registered holder of ** ZERO ** FULLY PAID AND NON-ASSESSABLE COMMON SHARES WITHOUT PAR VALUE ASPREVA PHARMACEUTICALS CORPORATION in the Authorized share structure of the above named Corporation subject to the Articles of the Corporation transferable on the Central Securities Register of the Corporation by the registered holder in person or by attorney duly authorized in writing upon surrender of this certificate properly endorsed. This certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Corporation. IN WITNESS WHEREOF the Corporation has caused this certificate to be signed on its behalf by the facsimile signatures of its duly authorized officers, at Victoria, British Columbia. Dated [date] COUNTERSIGNED AND REGISTERED COMPUTERSHARE INVESTOR SERVICES INC. VOID (VANCOUVER) (TORONTO) (DENVER) TRANSFER AGENT AND REGISTRAR /s/ RICHARD GLICKMAN /s/ BRUCE COUSINS Chief Executive Officer Chief Financial Officer By VOID ----------------------------------------------------- Authorized Officer The shares represented by this certificate are transferable at the offices of Computershare Investor Services Inc. in Vancouver, BC, Toronto, ON and Denver, CO. SECURITY INSTRUCTIONS ON REVERSE VOIR LES INSTRUCTIONS DE SECURITE AU VERSO 104598 "Until the Separation Time (as defined in the Rights Agreement referred to below), this certificate also evidences and entitles the holder hereof to certain Rights as set forth in the Shareholder Rights Plan Agreement, dated as of the 4th day of February, 2005 as such may be from time to time amended, restated, varied or replaced, between Aspreva Pharmaceuticals Corporation (the "Corporation") and a Computershare Investor Services Inc., as Rights Agent (the "Rights Agreement"), the terms of which are hereby incorporated herein by reference and a copy of which is on file at the principal executive offices of the Corporation. Under certain circumstances, as set forth in the Rights Agreement, such Rights may be amended or redeemed, may expire, may become void (if, in certain cases, they are "BENEFICIALLY OWNED" by an "Acquiring Person", as such terms are defined in the Rights Agreement) whether currently held or on behalf of such Person or any subsequent holder or may be evidenced by separate certificates and may no longer be evidenced by this certificate. The Corporation will mail or arrange for the mailing of a copy of the Rights Agreement to the holder of this certificate without charge within five days after the receipt of a written request therefore." The following abbreviations shall be construed as though the words set forth below opposite each abbreviation were written out in full where such abbreviation appears: TEN COM - as tenants in common TEN ENT - as tenants by the entireties JT TEN - as joint tenants with rights of survivorship and not as tenants in common (Name) CUST (Name) UNIF - (Name) as Custodian for (Name) under the GIFT MIN ACT (State) (State) Uniform Gifts to Minors Act Additional abbreviations may also be used though not in the above list. ------------------------- * Please insert Social Insurance, Tax Identification, or other identifying number of transferee. ------------------------- For value received the undersigned hereby sells, assigns and transfers unto - -------------------------------------------------------------------------------- Insert name and address of transferee - -------------------------------------------------------------------------------- - -------------------------------------------------------------------------------- shares represented by this certificate and does hereby irrevocably constitute and appoint - -------------------------------------------------------------------------------- the attorney of the undersigned to transfer the said shares on the books of the Corporation with full power of substitution in the premises. DATED: ---------------------- ---------------------- ---------------------- Signature Signature of Shareholder of Guarantor SIGNATURE GUARANTEE: The signature on this assignment must correspond with the name as written upon the face of the certificate(s), in every particular, without alteration or enlargement, or any change whatsoever and must be guaranteed by a major Canadian Schedule I chartered bank, a major trust company in Canada or a member of an acceptable Medallion Signature Guarantee Program (STAMP, SEMP, MSP). The Guarantor must affix a stamp bearing the actual words "Signature Guaranteed". In the USA, signature guarantees must be done by members of a "Medallion Signature Guarantee Program" only. Signature guarantees are not accepted from Treasury Branches, Credit Unions or Caisses Populaires unless they are members of the Stamp Medallion Program. COMPUTERSHARE'S PRIVACY NOTICE: In the course of providing services to you and our corporate clients, Computershare receives non-public personal information about you - your name, address, social insurance number, securities holdings, transactions, etc. We use this to administer your account, to better serve your and our clients' needs and for other lawful purposes. We have prepared a Privacy Code to tell you more about our information practices and how your privacy is protected. It is available at our website, computershare.com, or by writing us at 100 University Avenue, Toronto, Ontario, M5J 2Y1. *You are required to provide your SIN if you will receive income on these securities. We will use this number for income reporting. Computershare may also ask for your SIN as an identification-security measure if you call or write to request service on your account; however you may decline this usage. SECURITY INSTRUCTIONS - INSTRUCTIONS DE SECURITE THIS IS WATERMARKED PAPER, DO NOT ACCEPT WITHOUT NOTING WATERMARK, HOLD TO LIGHT TO VERIFY WATERMARK. [MAP] PAPIER FILIGRANE, NE PAS ACCEPTER SANS VERIFIER LA PRESENCE DU FILIGRANE. POUR CE FAIRE, PLACER A LA LUMIERE. 0061RB