<MOORE STEPHENS, P.C.LETTERHEAD> MOORE STEPHENS, P.C. CERTIFIED PUBLIC ACCOUNTANTS Exhibit 16.1 ------------- April 11, 2000 Securities and Exchange Commission 450 5th Street, N.W. Washington, DC 20549 Ladies and Gentlemen: We have read the statements made by Embryo Development Corporation (the "Company") (File No. 0-27028) which we understand will be filed with the Securities and Exchange Commission (the "Commission"), pursuant to the requirements of Item 4 of Form 8-K, as part of the Company's Current Report on Form 8-K to be filed with the Commission. We agree with the statements made concerning Moore Stephens, P.C. in such Form 8-K. Sincerely, /s/ Moore Stephens, P.C. ------------------------ CRANFORD OFFICE 340 North Avenue, Cranford, NJ 07016-2496 TELEPHONE 908-272-7000 FAX 908-272-7101 Member of the American Institute of Certified Public Accountants SEC and Private Companies Practice Sections