Exhibit 10.3

THE SECURITIES  REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY
NOT BE OFFERED FOR SALE, SOLD,  TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN
EFFECTIVE  REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF
1933,  AS AMENDED,  OR  APPLICABLE  STATE  SECURITIES  LAWS OR (B) AN OPINION OF
COUNSEL,  REASONABLY  SATISFACTORY  TO THE  COMPANY,  THAT  REGISTRATION  IS NOT
REQUIRED UNDER SAID ACT OR APPLICABLE  STATE SECURITIES LAWS. THE SECURITIES MAY
BE PLEDGED IN CONNECTION  WITH A BONA FIDE MARGIN  ACCOUNT OR OTHER LOAN SECURED
BY THE SECURITIES.

No.                                                         $
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                           HEMISPHERX BIOPHARMA, INC.

       SERIES B 7% SENIOR SECURED CONVERTIBLE DEBENTURE DUE JUNE 30, 2007

THIS  DEBENTURE  (this  "Debenture")  is  one  of a  duly  authorized  issue  of
replacement  Debentures  of  HEMISPHERX  BIOPHARMA,  INC.,  a  corporation  duly
organized and existing under the laws of the State of Delaware (the  "Company"),
now  designated as its 7% Senior  Secured  Convertible  Debentures  Due June 30,
2007.  The Debenture is one of a series of  debentures  that amend and replace a
series of 6% Senior Convertible  Debentures due January 31, 2006,  originally in
an  aggregate  principal  amount  of up  to  Four  Million  U.S.  Dollars  (U.S.
$4,000,000) (the  "Debentures").  The Debenture and the Series A and Series C 7%
Senior Secured  Convertible  Debentures Due June 30, 2007 are pari passu and the
designation of series is for identification purposes only.


                  FOR  VALUE  RECEIVED,  the  Company  promises  to pay to , the
holder hereof,  or its registered  assigns (the "Holder"),  the principal sum of
Dollars($____) when due, whether  on June 30,  2007  (subject  to  extension  as
provided herein, the "Maturity Date") or on any Installment Date with respect to
the Installment  Amount due on such  Installment Date (each, as defined herein),
and to pay interest ("Interest Payments") on the Outstanding Principal Amount at
the rate of 7% per annum which shall be  cumulative,  accrue,  but not compound,
daily from the date of  issuance  of this  Debenture  and be due and  payable in
arrears on the first day of each Quarterly Period  commencing with the Quarterly
Period  immediately  following the date of issuance of this Debenture  (each, an
"Interest  Payment Date").  If the Maturity Date is not a Business Day, then the
Maturity Date shall be deemed to be the Business Day immediately  following such
date.  If an Interest  Payment  Date is not a Business  Day,  then the  Interest
Payment shall be due and payable on the Business Day immediately  following such
Interest  Payment  Date.  Subject  to the  limitations  in  Sections  11 and 26,
interest  shall be payable by the issuance of shares of Common Stock  ("Interest
Shares")  to the  Holder or, at the  option of the  Company,  in cash (the "Cash
Interest  Payment");  provided,  however,  that the  Company  may not make  Cash
Interest  Payments and  interest  payments  shall be payable in Interest  Shares
unless the Company provides written notice to each holder of Debentures at least
five  Business  Days prior to the  applicable  Interest  Payment  Date that such
Interest  Payments  shall be made in cash.  Interest  Shares  shall be paid in a
number of fully paid and nonassessable shares (rounded up or down to the nearest
whole  share) of Common  Stock  equal to the  quotient  of (1) the amount of the
Interest  Payment due on the  applicable  Interest  Payment  Date divided by (2)
ninety-five percent (95%) of the arithmetic average of the Closing Sale Price of
the Common Stock on the five  consecutive  Business Days ending on and including
the third Business Day  immediately  preceding the applicable  Interest  Payment
Date (the "Interest Share Conversion Rate"); provided, further; that in no event
may the Company  issue more than an aggregate  of 40,000  shares of Common Stock
(as  equitably  adjusted for any stock  dividend,  stock split or other  similar
transaction), pro rata among all holders of Debentures, in respect of any single
Interest  Payment (it being  understood  that the balance of each such  Interest
Payment shall be paid in the form of a Cash Interest  Payment).  Notwithstanding
the foregoing,  the Company shall be required to make a Cash Interest Payment on
any Interest  Payment Date if (a) any event  constituting an Event of Default or
an event that with the passage of time and without being cured would  constitute
an Event of Default, has occurred and is continuing on the Interest Payment Date
or any date which is within 10 Business Days prior to the Interest Payment Date,
unless otherwise consented to in writing by the holder of the Debenture entitled
to  receive  such  Interest  Payment  or (b) from and  after  the time  that any
Registration  Statement (as defined in the Registration  Rights  Agreement,  the
"Registration  Statement")  is  required  to  be  effective,  such  Registration
Statement  is not then  effective  and  available  for the  resale of all of the
Registrable  Securities (as defined in the Registration Rights Agreement) on the
Interest Payment Date or each date which is within 10 Business Days prior to the
Interest  Payment Date. Any accrued and unpaid interest which is not paid within
five (5)  Business  Days of the  Interest  Payment Date on which such payment of
interest  was due shall bear  interest  at the rate of 14.0% per annum from such
Interest  Payment Date until the same is paid in full (or, if less,  the maximum
interest rate then permitted by applicable law) (the "Default Interest").

                  Interest  Payments and payments of principal will be paid only
to the  person  in  whose  name  this  Debenture  (or  one or  more  predecessor
Debentures) is registered on the records of the Company  regarding  registration
and transfers of the Debentures (the "Debenture Register").

                  This   Debenture  is  subject  to  the  following   additional
provisions:

1. Exchange.  The Debentures are exchangeable  for an equal aggregate  principal
amount of  Debentures  of  different  denominations,  as requested by the Holder
surrendering  the same. No service charge will be charged to the Holder for such
registration transfer or exchange.

2.   Transfers.   This   Debenture   has  been  issued   subject  to  investment
representations  of the  original  purchaser  hereof and may be  transferred  or
exchanged in the United States only in  compliance  with the  Securities  Act of
1933, as amended (the "Act"), and applicable state securities laws. Prior to due
presentment for transfer of this Debenture,  the Company may treat the person in
whose name this Debenture is duly registered on the Company's Debenture Register
as the owner hereof for the purpose of receiving  payment as herein provided and
all other  purposes,  whether or not this Debenture is overdue,  and the Company
shall not be affected by notice to the contrary.

3. Definitions. For purposes of this Debenture, the location of defined terms in
this  Debenture  is set  forth on the  Index of Terms  attached  hereto  and the
following terms shall have the following meanings:

                  "Account  Control  Agreement"  shall have the meaning ascribed
thereto in the Securities Purchase Agreement.

                  "Agent" shall mean Portside Growth & Opportunity  Fund, in its
capacity as collateral agent for the holders of Debentures, and any successor in
such capacity.

                  "Approved  Stock Plan shall mean any  employee  benefit  plan,
stock  incentive  plan or  other  similar  plan or  arrangement  which  has been
approved by the Board of  Directors of the Company or any  authorized  committee
thereof,  pursuant  to which  the  Company's  securities  may be  issued  to any
employee, officer, consultant or director for services provided to the Company.

                  "ASE" shall mean The American Stock Exchange.
                   ---

                  "Bloomberg"  shall  mean  Bloomberg  Financial  Markets or any
other similar  financial  reporting service as may be selected from time to time
by the  Company  and the  holders  of not less than 60% of the then  Outstanding
Principal Amount of Debentures issued on the Original Issuance Date.

                  "Business Day" shall mean any day other than Saturday,  Sunday
or any  other  day on  which  commercial  banks  in The  City  of New  York  are
authorized or required by law to remain closed.

                  "Cash Collateral Account" shall mean the account maintained by
the Company at the Cash Collateral  Account Bank, in the name of Portside Growth
& Opportunity Fund  ("Portside") and subject to the control of Portside pursuant
to the Account Control Agreement, together with any successor account designated
by Portside.  The Cash Collateral Account referred to herein is the same account
being used for all debentures of the Company,  including replacement debentures,
originally issued to Portside and Leonardo L.P. (collectively "PL Debentures").


                  "Cash  Collateral  Account  Bank"  shall  mean  the  financial
institution  designated  as the Cash  Collateral  Account Bank under the Account
Control Agreement.

                  "Cash  Transaction" shall mean any Organic Change with a third
party on an arm's length basis pursuant to which the holders of the Common Stock
are to receive consideration consisting solely of cash.

                  "Closing  Sale Price"  shall mean,  for any security as of any
date, the last closing trade price for such security on the Principal  Market as
reported  by  Bloomberg,  or if the  Principal  Market  begins to  operate on an
extended hours basis,  and does not designate the closing trade price,  then the
last trade price at 4:00 p.m., New York City Time, as reported by Bloomberg,  or
if the foregoing do not apply,  the last closing trade price of such security in
the  over-the-counter  market on the electronic bulletin board for such security
as reported by  Bloomberg,  or, if no last  closing  trade price is reported for
such  security by  Bloomberg,  the last  closing  ask price of such  security as
reported by  Bloomberg,  or, if no last  closing ask price is reported  for such
security by  Bloomberg,  the average of the highest bid price and the lowest ask
price of any market makers for such security as reported in the "pink sheets" by
the Pink Sheets LLC. If the Closing  Sale Price  cannot be  calculated  for such
security on such date on any of the foregoing  bases,  the Closing Sale Price of
such security on such date shall be the fair market value as mutually determined
by the Company and the holders of no less than 60% of the Outstanding  Principal
Amount of the Debentures  issued on the Original Issuance Date then outstanding.
If the Company and the  holders of the  Debentures  are unable to agree upon the
fair  market  value of the Common  Stock,  then such  dispute  shall be resolved
pursuant  to  Section  4(e)(iii)  below.  All  such   determinations   shall  be
appropriately  adjusted  for any stock  dividend,  stock split or other  similar
transaction during such period.

                  "Collateral" shall mean all of the property and assets,  other
than Intellectual  Property,  and all interests therein and proceeds thereof now
owned or hereafter  acquired by the  Company,  any of its  Subsidiaries  and any
other  Person  upon which a Lien is granted or  purported  to be granted by such
Person as security for all or any part of the  obligations  of the Company under
the Debentures.

                  "Common  Stock" shall mean the Common Stock,  par value $0.001
per share, of the Company.

                  "Common  Stock Deemed  Outstanding"  shall mean,  at any given
time,  the number of shares of Common Stock  actually  outstanding at such time,
plus the number of shares of Common Stock deemed to be  outstanding  pursuant to
Sections  6(a)(i)  and  6(a)(ii)  hereof  regardless  of whether  the Options or
Convertible  Securities are actually exercisable at such time, but excluding any
shares of Common  Stock  owned or held by or for the  account of the  Company or
issuable upon conversion of the Debentures or exercise of the Warrants.

                  "Conversion Failure" shall mean that for any reason the Holder
has not  received  all of the  shares  of Common  Stock to which  the  Holder is
entitled  prior to the tenth (10th)  Business Day after the Share  Delivery Date
with respect to a conversion of this Debenture.

                  "Conversion Price" shall mean (A) as of any Conversion Date or
other date of determination (other than with respect to an Installment Amount on
an Installment  Date pursuant to a Company  Conversion (as defined in Section 24
(a)), the Fixed Conversion Price, and (B) with respect to any Installment Amount
on an Installment  Date pursuant to a Company  Conversion,  at the option of the
Holder,  either the Fixed Conversion  Price or the Company  Conversion Price (as
defined  in  Section  24(d)),  each in  effect as of such  date and  subject  to
adjustment as provided herein.

                  "Convertible  Securities"  shall mean any stock or  securities
(other than Options) directly or indirectly  convertible into or exchangeable or
exercisable for Common Stock.

                  "Default  Conversion  Price"  shall  mean the lower of (a) the
Conversion  Price then in effect and (b) 95% of the  lowest  Closing  Sale Price
during the three (3) trading days ending on and including the Conversion Date or
other date of determination.

                  "Fixed  Conversion Price" shall mean as of any Conversion Date
or other date of  determination  $2.08,  subject to  adjustment  as  provided in
Section 6, Anti-dilution Adjustments to Conversion Price.

                  "Intellectual  Property"  means all  trademarks,  trade names,
trade dress, service marks, service mark registrations,  service names, patents,
patent  rights,   copyrights,   inventions,   technology  licenses,   approvals,
governmental  authorizations,  trade  secrets  and other  intellectual  property
rights.

                  "Interferon Acquisition" shall mean the acquisition of certain
assets and technology of Interferon Sciences,  Inc.  ("Interferon")  pursuant to
asset purchase  agreements,  dated as of March 11, 2003, between the Company and
Interferon,  a true and complete copy of which has been delivered by the Company
to each initial holder of Debentures in accordance with the Securities  Purchase
Agreement.

                  "Letters of Credit" shall mean the irrevocable standby letters
of  credit  in the  aggregate  stated  amount  of  $1,000,000  issued  by  banks
acceptable to the Agent and naming the Agent as beneficiary,  and any letters of
credit issued in  substitution  or replacement  thereof,  in accordance with the
Securities Purchase Agreement.

                  "Mortgage" shall mean each mortgage,  deed of trust or deed to
secure debt, made by the Company in favor of the Agent and recorded against each
real property location  acquired by the Company from Interferon  pursuant to the
Interferon Acquisition.

                  "NASDAQ"  shall mean The Nasdaq  National  Market,  The Nasdaq
Small Cap Market or the ASE.

                  "NYSE" shall mean The New York Stock Exchange, Inc.
                   ----

                  "Options"  shall  mean any  rights,  warrants  or  options  to
subscribe for or purchase Common Stock or Convertible Securities.

                  "Original  Issuance  Date" shall mean  January 26,  2004,  the
first date on which any Debentures  have been issued  pursuant to the Securities
Purchase Agreement.

                  "Outstanding  Principal  Amount"  shall mean the principal sum
outstanding from time to time under this Debenture.

                  "Person"  shall  mean  an  individual,   a  limited  liability
company,  a  partnership,   a  joint  venture,   a  corporation,   a  trust,  an
unincorporated  organization  and a  government  or  any  department  or  agency
thereof.

                  "Principal  Market" shall mean the ASE, or if the Common Stock
is not traded on the ASE,  then the  principal  securities  exchange  or trading
market for the Common Stock.

                  "Quarterly  Period" shall mean each of the following  periods:
the period  beginning  on and  including  January 1 and ending on and  including
March 31;  the  period  beginning  on and  including  April 1 and  ending on and
including  June 30, the period  beginning on and including  July 1 and ending on
and including  September 30; and the period beginning on and including October 1
and ending on and including December 31.

                  "Registration   Rights  Agreement"  shall  mean  that  certain
registration rights agreement between the Company and the initial holders of the
Debentures  relating  to the filing of a  registration  statement  covering  the
resale of the shares of Common Stock issuable upon  conversion of the Debentures
and exercise of the Warrants, as such agreement may be amended from time to time
as provided in such agreement.

                  "SEC" shall mean the United  States  Securities  and  Exchange
Commission.

                  "Securities   Purchase  Agreement"  shall  mean  that  certain
securities purchase agreement between the Company and the initial holders of the
Debentures,  as such  agreement  may be amended from time to time as provided in
such agreement.

                  "Security Agreement" shall mean that certain third amended and
restated  security  agreement  made by the Company in favor of the Agent for the
benefit of all holders of the Debentures,  as such agreement may be amended from
time to time as provided in such agreement.

                  "Strategic  Financing" shall mean the issuance of Common Stock
or Options in connection with any acquisition by the Company, by whatever means,
of any business, assets or technologies,  or to any strategic investor,  vendor,
customer,  lease or similar arrangement,  the primary purpose of which is not to
raise equity  capital;  provided that the  aggregate  number of shares of Common
Stock which the Company may issue pursuant to this  definition  shall not exceed
(i)  25% of the  total  outstanding  equity  on the  Original  Issuance  Date in
connection  with  any one or more  related  issuances  to  strategic  investors,
vendors,  customers,  lessors  or  similar  parties  or  (ii)  40% of the  total
outstanding  equity  on the  Original  Issuance  Date  in  connection  with  all
issuances to strategic investors, vendors, customers, lessors or similar parties
(in each case,  subject to adjustment for stock splits,  stock dividends,  stock
combinations and similar transactions).

                  "Subsidiary" shall mean, as to any Person, any entity in which
such Person,  directly or  indirectly,  owns 30% or more of the capital stock or
other equity or similar  interests  or owns capital  stock or holds an equity or
similar  interest which  ownership  entitles such Person to elect 30% or more of
the board of directors or similar governing body of such entity.

                  "Transaction   Documents"  shall  have  the  meaning  ascribed
thereto in the Securities Purchase Agreement.

                  "Warrants"  shall  mean the  warrants  to  purchase  shares of
Common  Stock  issued  by  the  Company  pursuant  to  the  Securities  Purchase
Agreement.

                  "Weighted  Average  Price" shall mean,  for any security as of
any date, the dollar  volume-weighted  average price per share for such security
on the Principal  Market during the period beginning at 9:30 a.m., New York City
Time,  and ending at 4:00 p.m.,  New York City Time,  as reported  by  Bloomberg
through its "Volume at Price" function or, if the foregoing does not apply,  the
dollar  volume-weighted  average  price  per  share  of  such  security  in  the
over-the-counter  market on the  electronic  bulletin  board  for such  security
during the period beginning at 9:30 a.m., New York City Time, and ending at 4:00
p.m.,  New  York  City  Time,  as  reported  by  Bloomberg,  or,  if  no  dollar
volume-weighted  average  price is reported for such  security by Bloomberg  for
such hours,  the average of the highest closing bid price and the lowest closing
ask price of any of the market makers for such security as reported in the "pink
sheets"  by the Pink  Sheets  LLC.  If the  Weighted  Average  Price  cannot  be
calculated  for such  security on such date on any of the foregoing  bases,  the
Weighted  Average  Price of such  security on such date shall be the fair market
value as mutually  determined by the Company and the holders of no less than 60%
of the  Outstanding  Principal  Amount of the Debentures  issued on the Original
Issuance Date then outstanding. If the Company and the holders of the Debentures
are unable to agree upon the fair market  value of the Common  Stock,  then such
dispute shall be resolved  pursuant to Section 4(e)(iii) with the term "Weighted
Average  Price" being  substituted  for the term  "Closing Sale Price." All such
determinations  shall be  appropriately  adjusted for any stock dividend,  stock
split or other similar transaction during such period.

4. Conversion.  The Holder of this Debenture shall have the following conversion
rights:


(a)  Holder's  Right to  Convert.  Subject to Sections 11 and 26, at any time or
times  until 5:00 p.m.,  New York City Time,  on the  Business  Day prior to the
Maturity Date this Debenture is convertible, at the option of the Holder hereof,
into fully paid,  validly  issued and  nonassessable  shares of Common  Stock in
accordance  with Section 4(d) at the  Conversion  Rate (as defined  below).  The
Holder hereof may convert a portion of the Outstanding  Principal Amount of this
Debenture if such portion is an integral  multiple of $1,000.  If this Debenture
remains  outstanding on the Maturity Date, then this Debenture shall be redeemed
by the Company in accordance with Section 5(a).  Notwithstanding anything herein
to the contrary,  concurrent with each delivery of Conversion Shares to a holder
pursuant to this Debenture,  the Company shall pay (in Interest Shares,  only if
all terms,  conditions and requirements  set forth in this Debenture  concerning
payment of  interest in the form of Interest  Shares are  satisfied,  or cash as
determined by the Company) to such holder all accrued and unpaid interest on the
Outstanding  Principal  Amount then being  converted from the last date on which
interest  had  been  paid on  such  Outstanding  Principal  Amount  through  the
Conversion Date.

(b)  Company's  Right to  Mandatory  Conversion.  Subject to  Sections 11 and 26
hereof,  if at any time from and after the Original  Issuance  Date the Weighted
Average Price of the Common Stock shall exceed 175% of the Conversion  Price for
any 25 consecutive trading days (the "Mandatory  Conversion  Measuring Period"),
the Company may deliver on or before the second (2nd) Business Day following the
end of the Mandatory  Conversion  Measuring  Period a written notice to all, but
not less than all, of the Holders and the Transfer  Agent (as defined in Section
4(e)(i)) (the  "Mandatory  Conversion  Notice"),  indicating that the Company is
requiring each Holder to convert the then  Outstanding  Principal Amount of such
Holder's  Debenture plus accrued and unpaid  interest  thereon to the date fixed
for  conversion  into fully paid,  validly  issued and  nonassessable  shares of
Common Stock in accordance with Section 4(d) hereof at the Conversion Rate as of
the Mandatory Conversion Date (as defined below);  provided,  however,  that the
Company may not require such  conversion  if (i) an Event of Default  shall have
occurred at any time on or prior to the Mandatory Conversion Date and shall have
not been cured to the reasonable  satisfaction  of the holder of this Debenture,
(ii) an event shall have  occurred and be  continuing at any time on or prior to
the Mandatory  Conversion Date which with the passage of time and the failure to
cure would  result in an Event of  Default,  (iii)  either (A) any  Registration
Statement is not  effective  and  available  for the sale of at least all of the
Registrable  Securities  (as  defined  in  the  Registration  Rights  Agreement)
required to be included in such Registration Statement or (B) there has been any
Grace Period,  in either case on any trading day during the period  beginning on
the first day of the  Mandatory  Conversion  Measuring  Period and ending on the
Mandatory  Conversion  Date or (iv)  there has been a public  announcement  of a
pending,  proposed or intended Change of Control, unless such pending,  proposed
or intended Change of Control has been terminated,  abandoned or consummated and
the Company has publicly announced such termination, abandonment or consummation
of such Change of Control (a "Mandatory Conversion"). The Company shall send the
Mandatory  Conversion  Notice by facsimile and overnight  courier to each Holder
and shall  indicate (X) the date fixed for  conversion,  which shall be not less
than  fifteen  (15) days nor more than  thirty  (30) days  after  each  Holder's
receipt of the Mandatory  Conversion Notice (the "Mandatory  Conversion  Date"),
(Y) the  Conversion  Price and (Z) the  number  of shares of Common  Stock to be
issued to such Holder as of the  Mandatory  Conversion  Date. If the Company has
elected a Mandatory Conversion, the mechanics of conversion set forth in Section
4(e) shall apply, to the extent  applicable,  as if the Company and the Transfer
Agent  had  received  from  each  Holder  on  the  Mandatory  Conversion  Date a
Conversion  Notice (as  defined  below) with  respect to the entire  Outstanding
Principal Amount of the Debenture and the interest accrued and unpaid thereon as
of the Mandatory  Conversion Date.  Promptly following the Mandatory  Conversion
Date,  the Holder shall  surrender  its Debenture to the Company or the Transfer
Agent.

(c) Partial Conversion of Debenture. If this Debenture is converted in part, the
remaining  portion of this Debenture not so converted  shall remain  entitled to
the conversion rights provided herein.

(d) Conversion  Price for Holder  Converted  Shares.  The Outstanding  Principal
Amount of this  Debenture that is converted into shares of Common Stock shall be
convertible  into the  number  of  shares of Common  Stock  which  results  from
application of the following formula:

                                        P
                                ----------------
                                Conversion Price

   P = Outstanding Principal Amount of this Debenture submitted for conversion

                  The number of shares of Common Stock into which this Debenture
hereto may be converted  pursuant to the foregoing formula is hereafter referred
to as the "Conversion Rate."

(e) Mechanics of Conversion. The conversion of this Debenture shall be conducted
in the following manner:

(i) Holder's  Delivery  Requirements.  To convert this Debenture (in whole or in
part)  into full  shares  of Common  Stock on any  date,  the  Holder  shall (A)
transmit by facsimile (or otherwise physically deliver), for receipt on or prior
to 5:00 p.m.,  New York City Time, on such date, a copy of a properly  completed
notice of  conversion  executed  by the  Holder in the form  attached  hereto as
Exhibit I (the "Conversion  Notice") to the Company and the Company's designated
transfer  agent (the  "Transfer  Agent") and (B) surrender  this  Debenture to a
common carrier for delivery to the Company as soon as practicable following such
date.

(ii) Company's  Response.  Upon receipt by the Company of a copy of a Conversion
Notice,  the Company shall (A) as soon as  practicable,  but in any event within
two (2) Business Days,  send, via facsimile,  a confirmation  of receipt of such
Conversion  Notice to such holder and the  Transfer  Agent,  which  confirmation
shall constitute an instruction to the Transfer Agent to process such Conversion
Notice in accordance with the terms herein and (B) then, on or before the second
(2nd)  Business  Day  following  the  date of  receipt  by the  Company  of such
Conversion  Notice (the  "Share  Delivery  Date"),  (x) issue and deliver to the
address as specified in the Conversion Notice, a certificate,  registered in the
name of the Holder or its designee,  for the number of shares of Common Stock to
which the Holder  shall be  entitled,  or (y) in the case of a public  resale of
such  Conversion  Shares in accordance  with the  provisions of the  Irrevocable
Transfer Agent Instructions, provided the Transfer Agent is participating in The
Depository Trust Company ("DTC") Fast Automated Securities Transfer Program and,
if required by DTC,  the holder  provides a customary  representation  letter to
DTC, upon the request of the holder,  credit such aggregate  number of shares of
Common Stock to which the holder  shall be entitled to the  holder's  designee's
balance account with DTC through its Deposit Withdrawal Agent Commission system.
If the specified principal amount submitted for conversion is less than the then
Outstanding Principal Amount of this Debenture,  then the Company shall, as soon
as practicable  using  reasonable best efforts,  and in no event later than five
Business Days after receipt of the Debenture (the "Debenture Delivery Date") and
at its own expense, issue and deliver to the holder a new Debenture representing
the Outstanding Principal Amount not converted. The effective date of conversion
(the  "Conversion  Date")  shall be deemed  to be the date on which the  Company
receives by facsimile the Conversion  Notice, and the Person or Persons entitled
to receive the shares of Common Stock  issuable  upon such  conversion  shall be
treated  for all  purposes  as the record  holder or  holders of such  shares of
Common Stock on such date.

(iii) Dispute  Resolution.  In the case of a dispute as to the  determination of
the Closing Sale Price,  the Weighted Average Price, the Conversion Price or the
arithmetic  calculation of the  Conversion  Rate, the Company shall instruct the
Transfer  Agent to issue to the Holder the number of shares of Common Stock that
is not disputed and shall transmit an explanation of the disputed determinations
or arithmetic  calculations to the Holder via facsimile  within two (2) Business
Days  of  receipt  of  the   Holder's   Conversion   Notice  or  other  date  of
determination.  If the  Holder  and the  Company  are  unable to agree  upon the
determination  of the Closing  Sale  Price,  the  Weighted  Average  Price,  the
Conversion Price or arithmetic calculation of the Conversion Rate within two (2)
Business Days of such disputed  determination  or arithmetic  calculation  being
transmitted  to the Holder,  then the Company shall within two (2) Business Days
submit via facsimile (A) the disputed  determination  of the Closing Sale Price,
the  Weighted  Average  Price or the  Conversion  Price,  as  applicable,  to an
independent,  reputable  investment bank selected by the Company and approved by
the  holders  of at  least  60%  of  the  Outstanding  Principal  Amount  of the
Debentures  issued on the Original  Issuance  Date then  outstanding  or (B) the
disputed  determination  of the Conversion  Price, the Weighted Average Price or
the Conversion Price, as applicable,  or the disputed arithmetic  calculation of
the  Conversion  Rate to the  Company's  independent,  outside  accountant.  The
Company shall cause the investment bank or the  accountant,  as the case may be,
to perform the  determinations  or  calculations  and notify the Company and the
holders of the  results no later  than ten (10)  Business  Days from the time it
receives the disputed determinations or calculations.  Such investment bank's or
accountant's determination or calculation,  as the case may be, shall be binding
upon all parties absent manifest error.

(iv)     Company's Failure to Timely Convert.
         -----------------------------------

(A) If (x) within  five (5)  Business  Days after the  Company's  receipt of the
facsimile  copy of a  Conversion  Notice  the  Company  has  failed to issue and
deliver a  certificate  to a Holder or credit the  Holder's  designee's  balance
account  with DTC,  in  accordance  with  Section  4(e) hereof for the number of
shares  of Common  Stock to which  the  Holder  is  entitled  upon the  Holder's
conversion  of this  Debenture  or (y)  within  five  (5)  Business  Days of the
Company's  receipt of this Debenture the Company has failed to issue and deliver
a  Debenture  representing  the  principal  amount  of  this  Debenture  not  so
converted,  then in addition to all other  available  remedies which such holder
may pursue  hereunder and under the  Securities  Purchase  Agreement  (including
indemnification pursuant to Section 8 thereof), the Company shall pay additional
damages  to such  holder  for each day after the Share  Delivery  Date that such
conversion is not timely effected  and/or each day after the Debenture  Delivery
Date that this  Debenture  is not  delivered  in an amount equal to 0.05% of the
product of (I) the sum of the number of shares of Common Stock not issued to the
holder  on or prior to the  Share  Delivery  Date and to which  such  holder  is
entitled as set forth in the applicable  Conversion Notice and, in the event the
Company  has  failed to  deliver a  Debenture  to the  holder on or prior to the
Debenture  Delivery  Date,  the number of shares of Common Stock  issuable  upon
conversion  of this  Debenture as of the  Debenture  Delivery  Date and (II) the
Closing Sale Price of the Common Stock on the Share  Delivery  Date, in the case
of the failure to deliver Common Stock,  or the Debenture  Delivery Date, in the
case of failure to  deliver a  Debenture.  The  foregoing  notwithstanding,  the
damages set forth in this Section  4(e)(iv)  shall be stayed with respect to the
number of shares of Common Stock for which there is a good faith  dispute  being
resolved pursuant to Section 4(e)(iii), pending the resolution of such dispute.

(B) If for any  reason a holder  has not  received  all of the  shares of Common
Stock to which such holder is entitled  prior to the tenth  (10th)  Business Day
after the Share  Delivery Date with respect to a conversion  of this  Debenture,
then the Holder, upon written notice to the Company, with a copy to the Transfer
Agent, may void its Conversion Notice; provided that the voiding of the Holder's
Conversion  Notice  shall  not  affect  the  Company's  obligations  to make any
payments which have accrued prior to the date of such notice pursuant to Section
4(e)(iv)(A) or otherwise.

(f) No Fractional Shares. The Company shall not issue any fraction of a share of
Common Stock upon any  conversion.  If the issuance would result in the issuance
of a fraction of a share of Common Stock,  the Company shall round such fraction
of a share of Common Stock up or down to the nearest whole share.

(g) Release of Funds from Segregated Account. Notwithstanding anything herein to
the  contrary,  if at any time and from time to time,  the  balance of the funds
remaining  in the  Segregated  Account  (as defined in the  Securities  Purchase
Agreement),  if any, that were paid into the  Segregated  Account by the initial
holder of this Debenture, as set forth on the Schedule of Buyers attached to the
Securities Purchase Agreement,  exceeds the then Outstanding Principal Amount of
this Debenture,  together with accrued  interest thereon and so long as no Event
of Default, or event that with notice or lapse of time would constitute an Event
of Default, has occurred and is continuing, the holder agrees, by its acceptance
of this Debenture, to distribute promptly to the Company an amount in cash equal
to such excess from the Segregated Account  established by the initial holder of
this Debenture,  or, if advised in writing by the Company, to use such excess to
remit  payment for any  obligation  under this  Debenture  to the holder of this
Debenture.  If for any  reason any  portion of the funds held in the  Segregated
Account  established by the initial holder of this Debenture are not paid to the
Company in accordance  with the terms of the Securities  Purchase  Agreement and
the Outstanding  Principal  Amount on this Debenture,  together with accrued and
unpaid  interest  thereon,  becomes due and  payable  either at maturity or upon
acceleration or demand upon an Event of Default,  the Company and the holder, by
its  acceptance of this  Debenture,  agree that the funds held in the Segregated
Account shall be released to the holder of this Debenture and shall be deemed to
constitute  a  partial  payment  of the  Outstanding  Principal  Amount  of this
Debenture  together with accrued interest thereon then due in an amount equal to
the funds in the  Segregated  Account.  All such  payments  from the  Segregated
Account shall be deemed to be payments of (i) first, accrued and unpaid interest
on  the  Outstanding  Principal  Amount  of  this  Debenture  and  (ii)  second,
Outstanding Principal Amount of this Debenture.

                  (h)  Application of Conversion  Amounts.  Subject to the final
sentence of Section 24(b),  any portion of this Debenture that the Holder elects
to convert in accordance with this Section 4 shall be deducted, at the option of
the Holder (as set forth in the applicable  Conversion Notice),  either (x) from
the  Installment  Amount  relating to the latest  Installment  Date  (i.e.,  the
Installment Date nearest to the Maturity Date) with respect to which Installment
Amounts remain  outstanding or (y) from the  Installment  Amount relating to the
nearest Installment Date (i.e., nearest to the Installment Date that has not yet
occurred).

5.       Redemption.
         ----------

(a) Mandatory  Redemption at Maturity.  If this Debenture remains outstanding on
the  Maturity  Date,  the  Company  shall  redeem (a  "Maturity  Date  Mandatory
Redemption")  the  Outstanding  Principal  Amount of this  Debenture that is not
subject  to a  Conversion  Notice  for an  amount in cash  (the  "Maturity  Date
Redemption  Price") equal to the Outstanding  Principal  Amount of the Debenture
not converted into shares of Common Stock pursuant to a Conversion Notice,  plus
accrued and unpaid interest thereon. The Maturity Date Redemption Price shall be
paid  on the  Maturity  Date  to the  Holder  by wire  transfer  of  immediately
available  funds to an account  designated  in writing by such Holder.  Promptly
following  payment of the  Maturity  Date  Redemption  Price,  the Holder  shall
surrender this Debenture to the Company.

(b) Payment Failures If the Company fails to make any payment of a Maturity Date
Redemption  Price, then in addition to any remedy the Holder may have under this
Debenture,  the  Securities  Purchase  Agreement  and  the  Registration  Rights
Agreement,  until the Maturity Date  Redemption  Price is paid in full,  (x) the
Maturity Date  Redemption  Price payable in respect of such unpaid Maturity Date
Redemption Price shall bear interest at the rate of 1.5% per month, prorated for
partial months,  and (y) the Holder shall have the option to require the Company
to convert  any or all of the  Outstanding  Principal  Amount of this  Debenture
subject to redemption and for which the Maturity Date Redemption Price (together
with any  interest  thereon) has not been paid into a number of shares of Common
Stock equal to the quotient of the Maturity Date Redemption Price (together with
any interest thereon) divided by the Default Conversion Price.

6.  Anti-dilution  Adjustments to Conversion Price. The Conversion Price will be
subject to  adjustment  from time to time as provided  in this  Section 6 at all
times prior to, but not after,  the date on which cash collateral  payments have
been made  pursuant to Section 25 in an amount  equal to the entire  Outstanding
Principal  Amount,  together with accrued and unpaid  interest on all Debentures
outstanding:

(a) Anti-dilution  Adjustment of Conversion Price upon Issuance of Common Stock.
If and whenever on or after the Original  Issuance  Date and prior to the twelve
(12) month  anniversary  of the Original  Issuance  Date,  the Company issues or
sells, or in accordance with this Section 6(a) is deemed to have issued or sold,
any shares of Common Stock (but excluding  shares of Common Stock: (v) deemed to
have been issued by the Company in connection  with an Approved  Stock Plan; (w)
deemed to have been issued upon issuance of the  Debentures or the Warrants,  or
issued upon conversion of the Debentures or exercise of the Warrants; (x) issued
upon exercise of Options or Convertible  Securities which are outstanding on the
date  immediately  preceding the Original  Issuance Date,  provided that (except
with regard to the  Previously-Issued  Securities  (as defined in the Securities
Purchase  Agreement))  such  issuance of shares of Common Stock upon exercise of
such Options or  Convertible  Securities  is made  pursuant to the terms of such
Options or Convertible  Securities in effect on the date  immediately  preceding
the Original  Issuance  Date,  such Options or  Convertible  Securities  are not
amended after the date  immediately  preceding the Original  Issuance Date other
than with respect to Options  originally  issued  pursuant to an Approved  Stock
Plan and the purchase or exercise  price  provided for in any such Options,  the
additional consideration,  if any, payable upon the issue, conversion,  exchange
or  exercise  of any such  Convertible  Securities,  or the  rate at  which  any
Convertible  Securities are convertible  into or exchangeable or exercisable for
Common Stock does not change at any time after the Original  Issuance  Date; (y)
issued to the public pursuant to an underwritten offering registered pursuant to
the Securities Act (but in all events  excluding  offerings  pursuant to "equity
lines" or similar  products);  and (z) issued pursuant to a Strategic  Financing
((v) through (z) collectively  "Excluded  Issuances"))  for a consideration  per
share (the "New Securities  Issuance  Price") less than the Conversion  Price in
effect  immediately prior to such time (each such sale or issuance,  a "Dilutive
Issuance"),  then concurrent with such Dilutive  Issuance,  the Conversion Price
then in  effect  shall be  reduced  to an  amount  equal  to the New  Securities
Issuance Price. If and whenever on or after the twelve (12) month anniversary of
the Original Issuance Date and prior to the Maturity Date, the Company issues or
sells, or in accordance with this Section 6(a) is deemed to have issued or sold,
any  shares of Common  Stock (but  excluding  shares of Common  Stock  issued or
deemed to have been issued  pursuant  to any  Excluded  Issuance)  in a Dilutive
Issuance, then concurrent with such Dilutive Issuance, the Conversion Price then
in effect shall be reduced to a price (rounded to the nearest cent) equal to the
product of (A) the Conversion Price in effect immediately prior to such Dilutive
Issuance  and (B) the  quotient  determined  by dividing  (1) the sum of (I) the
product derived by multiplying the Conversion Price in effect  immediately prior
to such  Dilutive  Issuance  and the  number of shares  of Common  Stock  Deemed
Outstanding   immediately   prior  to  such  Dilutive  Issuance  plus  (II)  the
consideration,  if any, received by the Company upon such Dilutive Issuance,  by
(2) the  product  derived  by  multiplying  (I) the  Conversion  Price in effect
immediately  prior to such  Dilutive  Issuance  by (II) the  number of shares of
Common Stock Deemed Outstanding  immediately after such Dilutive  Issuance.  For
purposes of determining the adjusted  Conversion  Price under this Section 6(a),
the following shall be applicable:

(i)  Issuance  of  Options.  If the  Company in any  manner  grants or sells any
Options  and the lowest  price per share for which one share of Common  Stock is
issuable  upon the exercise of any such Option or upon  conversion,  exchange or
exercise of any Convertible  Securities issuable upon exercise of such Option is
less than the  Conversion  Price in effect  immediately  prior to such  Dilutive
Issuance,  then such share of Common Stock shall be deemed to be outstanding and
to have been issued and sold by the Company at the time of the  granting or sale
of such Option for such price per share.  For purposes of this Section  6(a)(i),
the "lowest price per share for which one share of Common Stock is issuable upon
the exercise of any such Option or upon conversion,  exchange or exercise of any
Convertible  Securities issuable upon exercise of such Option" shall be equal to
the sum of the lowest amounts of  consideration  (if any) received or receivable
by the Company with  respect to any one share of Common  Stock upon  granting or
sale of the Option, upon exercise of the Option and upon conversion, exchange or
exercise of any Convertible  Security  issuable upon exercise of such Option. No
further  adjustment  of the  Conversion  Price  shall be made  upon  the  actual
issuance  of such  Common  Stock  or of such  Convertible  Securities  upon  the
exercise of such  Options or upon the actual  issuance of such Common Stock upon
conversion, exchange or exercise of such Convertible Securities.

(ii) Issuance of Convertible Securities.  If the Company in any manner issues or
sells any  Convertible  Securities  and the lowest price per share for which one
share of Common  Stock is issuable  upon such  conversion,  exchange or exercise
thereof is less than the Conversion  Price in effect  immediately  prior to such
Dilutive  Issuance,  then  such  share of  Common  Stock  shall be  deemed to be
outstanding  and to have been  issued and sold by the Company at the time of the
issuance of sale of such  Convertible  Securities for such price per share.  For
the purposes of this Section 6(a)(ii), the "lowest price per share for which one
share of Common Stock is issuable  upon such  conversion,  exchange or exercise"
shall  be equal  to the sum of the  lowest  amounts  of  consideration  (if any)
received or  receivable  by the Company  with respect to any one share of Common
Stock  upon  the  issuance  or sale of the  Convertible  Security  and  upon the
conversion,  exchange  or  exercise  of such  Convertible  Security.  No further
adjustment  of the  Conversion  Price shall be made upon the actual  issuance of
such Common  Stock upon  conversion,  exchange  or exercise of such  Convertible
Securities, and if any such issue or sale of such Convertible Securities is made
upon exercise of any Options for which  adjustment of the  Conversion  Price had
been or are to be made  pursuant to other  provisions  of this Section  6(a), no
further adjustment of the Conversion Price shall be made by reason of such issue
or sale.

(iii) Change in Option Price or Rate of Conversion.  If the purchase or exercise
price provided for in any Options, the additional consideration, if any, payable
upon the issue, conversion,  exchange or exercise of any Convertible Securities,
or the  rate  at  which  any  Convertible  Securities  are  convertible  into or
exchangeable or exercisable for Common Stock changes at any time, the Conversion
Price in effect at the time of such change  shall be adjusted to the  Conversion
Price  which  would  have  been in  effect  at such  time  had such  Options  or
Convertible  Securities  provided for such changed  purchase  price,  additional
consideration  or  changed  conversion  rate,  as the case  may be,  at the time
initially granted,  issued or sold. For purposes of this Section  6(a)(iii),  if
the terms of any Option or Convertible  Security that was  outstanding as of the
date of issuance of the  Debentures  are changed in the manner  described in the
immediately preceding sentence, then such Option or Convertible Security and the
Common Stock deemed issuable upon exercise, conversion or exchange thereof shall
be deemed to have been issued as of the date of such change. No adjustment shall
be made if such adjustment  would result in an increase of the Conversion  Price
then in effect.

(iv)  Calculation  of  Consideration  Received.  In case any Option is issued in
connection with the issue or sale of other  securities of the Company,  together
comprising one  integrated  transaction  in which no specific  consideration  is
allocated  to such Options by the parties  thereto,  then solely for purposes of
this  Section  6,  the  Options  will  be  deemed  to  have  been  issued  for a
consideration of $0.01. If any Common Stock,  Options or Convertible  Securities
are  issued  or sold or  deemed  to have  been  issued  or sold  for  cash,  the
consideration  received  therefor will be deemed to be the gross amount received
by the Company therefor. If any Common Stock, Options or Convertible  Securities
are  issued or sold for a  consideration  other  than  cash,  the  amount of the
consideration  other than cash received by the Company will be the fair value of
such  consideration,  except  where such  consideration  consists of  marketable
securities,  in which case the amount of  consideration  received by the Company
will be the  arithmetic  average of the Closing  Sale Prices of such  securities
during the ten (10)  consecutive  trading  days ending on the date of receipt of
such  securities.  The  fair  value  of any  consideration  other  than  cash or
securities will be determined jointly by the Company and the holders of at least
60% of the Outstanding Principal Amount of the Debentures issued on the Original
Issuance Date then  outstanding.  If such parties are unable to reach  agreement
within ten (10) days after the occurrence of an event  requiring  valuation (the
"Valuation  Event"),  the fair value of such  consideration  will be  determined
within five  Business  Days after the tenth (10th) day  following  the Valuation
Event by an  independent,  reputable  appraiser  selected by the Company and the
holders of at least 60% of the  Outstanding  Principal  Amount of the Debentures
issued on the Original Issuance Date then outstanding. The determination of such
appraiser shall be deemed binding upon all parties absent manifest error and the
fees and expenses of such appraiser shall be borne by the Company.

(v) Record  Date.  If the Company  takes a record of the holders of Common Stock
for  the  purpose  of  entitling  them  (A)  to  receive  a  dividend  or  other
distribution payable in Common Stock,  Options or Convertible  Securities or (B)
to subscribe for or purchase  Common Stock,  Options or Convertible  Securities,
then such  record date will be deemed to be the date of the issue or sale of the
shares of Common Stock  deemed to have been issued or sold upon the  declaration
of such  dividend  or the making of such other  distribution  or the date of the
granting of such right of subscription or purchase, as the case may be.

(b)  Adjustment of Conversion  Price upon  Subdivision  or Combination of Common
Stock.  If the  Company  at any  time  subdivides  (by any  stock  split,  stock
dividend,  recapitalization or otherwise) its outstanding shares of Common Stock
into a greater  number of shares,  the  Conversion  Price in effect  immediately
prior to such subdivision will be proportionately reduced. If the Company at any
time combines (by combination, reverse stock split or otherwise) its outstanding
shares of Common Stock into a smaller number of shares and the Conversion  Price
in  effect  immediately  prior  to  such  combination  will  be  proportionately
increased.

(c)  Holder's  Right of  Alternative  Conversion  Price  Following  Issuance  of
Convertible  Securities.   If  the  Company  issues  or  sells  any  Options  or
Convertible  Securities  after the Original  Issuance Date that are  convertible
into or  exchangeable or exercisable for Common Stock at a price which varies or
may vary with the market price of the Common  Stock,  including by way of one or
more reset(s) to a fixed price (each of the formulations for such variable price
being herein  referred to as, the "Variable  Price"),  the Company shall provide
written  notice  thereof via facsimile and overnight  courier to the Holder (the
"Variable  Notice") on the date of issuance of such  Convertible  Securities  or
Options.  From and  after  the  date the  Company  issues  any such  Convertible
Securities  or  Options  with a  Variable  Price,  but  only for so long as such
Convertible  Securities  or Options are  outstanding,  the Holder shall have the
right, but not the obligation, in its sole discretion to substitute the Variable
Price for the Conversion  Price upon  conversion of any Debentures held by it by
designating  in  the  Conversion   Notice  delivered  upon  conversion  of  such
Debentures  that solely for purposes of such conversion the Holder is relying on
the Variable Price rather than the Conversion Price then in effect. The Holder's
election to rely on a Variable  Price for a particular  conversion of Debentures
shall not  obligate  the  Holder  to rely on a  Variable  Price  for any  future
conversions of Debentures.

(d) Other Events. If any event occurs of the type contemplated by the provisions
of this Section 6 in a private  transaction  (the primary purpose of which is to
raise  equity  capital)  but  not  expressly  provided  for by  such  provisions
(including,  without  limitation,  the  granting of stock  appreciation  rights,
phantom stock rights or other rights with equity features other than pursuant to
an  Excluded  Issuance),  then the  Company's  Board of  Directors  will make an
appropriate  adjustment in the  Conversion  Price so as to protect the rights of
the holders of the  Debentures;  provided that no such  adjustment will increase
the Conversion Price as otherwise determined pursuant to this Section 6.

(e)      Notices.
         -------

(i) Promptly  following any adjustment of the Conversion  Price pursuant to this
Section 6, the Company will give written notice  thereof to the Holder,  setting
forth in reasonable detail, and certifying,  the calculation of such adjustment.
In the case of a dispute as to the  determination of such adjustment,  then such
dispute shall be resolved in accordance with the procedures set forth in Section
4(e)(iii).

(ii) The  Company  will  give  written  notice  to the  Holder at least ten (10)
Business Days prior to the date on which the Company closes its books or takes a
record (A) with respect to any dividend or  distribution  upon the Common Stock,
(B) with respect to any pro rata  subscription  offer to holders of Common Stock
or (C) for  determining  rights to vote with  respect to any Organic  Change (as
defined in Section 7(a)), dissolution or liquidation,  provided that the Company
need not in any case provide such notice prior to the time such  information  is
made known to the public.

(iii) The Company will also give written  notice to the Holder at least ten (10)
Business  Days prior to the date on which any  Organic  Change,  dissolution  or
liquidation  will take place,  provided  that the  Company  need not in any case
provide  such  notice  prior to the time such  information  is made known to the
public.

7.       Other Rights.
         ------------

(a)  Reorganization,  Reclassification,   Consolidation,  Merger  or  Sale.  Any
recapitalization,  reorganization, reclassification, consolidation, merger, sale
of all or  substantially  all of the Company's assets to another Person or other
transaction  which is  effected in such a way that  holders of Common  Stock are
entitled to receive  (either  directly or upon  subsequent  liquidation)  stock,
securities or assets with respect to or in exchange for Common Stock is referred
to herein as "Organic  Change." Prior to the consummation of any (i) sale of all
or  substantially  all of the  Company's  assets to an acquiring  Person or (ii)
other Organic Change following which the Company is not a surviving entity,  the
Company will secure from the Person purchasing such assets or the successor, or,
if applicable,  the parent of the successor,  resulting from such Organic Change
(in each case,  the "Acquiring  Entity") a written  agreement to deliver to each
holder of  Outstanding  Principal  Amount of the Debentures in exchange for such
securities, a security of the Acquiring Entity evidenced by a written instrument
substantially  similar in form and substance to the  Debentures,  and reasonably
satisfactory to the holders of at least 60% of the Outstanding  Principal Amount
of the  Debentures  issued  on the  Original  Issuance  Date  then  outstanding;
provided that the new security of the Acquiring  Entity shall not be required to
be of rank equal to the  Debenture if the issuance of a security of such rank is
not permitted by, or is inconsistent  with, any agreement or instrument to which
the Acquiring  Entity is a party or any security of the Acquiring Entity that is
outstanding,  upon  the  consummation  of  the  Organic  Change.  Prior  to  the
consummation  of any other Organic  Change,  the Company shall make  appropriate
provision to insure that each of the holders of the Debentures  will  thereafter
have the right to acquire  and receive in lieu of or in addition to (as the case
may be) the  shares of  Common  Stock  immediately  theretofore  acquirable  and
receivable upon the conversion of such holder's Debentures such shares of stock,
securities  or assets  that  would have been  issued or payable in such  Organic
Change with  respect to or in exchange  for the number of shares of Common Stock
which would have been  acquirable  and  receivable  upon the  conversion of such
holder's  Debentures as of the date of such Organic Change  (without taking into
account  any  limitations  or  restrictions   on  the   convertibility   of  the
Debentures).

(b) Optional Redemption at Holder's Election Upon Change of Control. In addition
to the rights of the holders of Debentures under this Debenture,  the Securities
Purchase  Agreement  and the  Registration  Rights  Agreement,  upon a Change of
Control (as defined  below) of the Company each holder of Debentures  shall have
the right,  at such holder's  option,  to require the Company to redeem all or a
portion of such holder's  Debentures at a price equal to 100% of the Outstanding
Principal  Amount of such  Debentures  plus the  product of (1) 1.75 and (2) the
dollar  amount of all  Interest  Payments  scheduled  to be paid  following  the
consummation  of the Change of Control and on or prior to the  Maturity  Date on
the  total  Outstanding  Principal  Amount  of the  Debentures  on the  date  of
consummation of the Change of Control ("Change of Control Redemption Price"). No
sooner  than 20  Business  Days nor later  than 10  Business  Days  prior to the
consummation of a Change of Control, but not prior to the public announcement of
such Change of Control,  the Company shall deliver  written  notice  thereof via
facsimile and overnight courier (a "Notice of Change of Control") to each holder
of Debentures. At any time during the period beginning after receipt of a Notice
of Change of  Control  (or,  in the event a Notice of Change of  Control  is not
delivered at least 10 Business Days prior to a Change of Control, at any time on
or after the date which is 10 Business  Days prior to a Change of  Control)  and
ending on the date one (1)  Business  Day prior to such Change of  Control,  any
holder of the Debentures then  outstanding may require the Company to redeem all
or a portion of the holder's  Debentures then outstanding by delivering  written
notice thereof via facsimile and overnight courier (a "Notice of Redemption Upon
Change of Control") to the Company,  which Notice of  Redemption  Upon Change of
Control shall  indicate (i) the  principal  amount of the  Debentures  that such
holder is submitting for redemption,  and (ii) the applicable  Change of Control
Redemption  Price,  as  calculated  pursuant  to this  Section  7(b).  Upon  the
Company's  receipt of a Notice(s) of Redemption  Upon Change of Control from any
holder of Debentures, the Company shall promptly, but in no event later than two
(2) Business Days  following  such receipt,  notify each holder of Debentures by
facsimile of the Company's  receipt of such Notice(s) of Redemption  Upon Change
of Control.  The Company shall  deliver to the holder of each  Debenture who has
delivered a Notice of Redemption upon Change of Control,  the applicable  Change
of Control Redemption Price  simultaneously  with the consummation of the Change
of Control  provided that a holder's  Debentures shall have been so delivered to
the Company.  For purposes of this Section 7(b),  "Change of Control" shall mean
(i) the consolidation,  merger or other business combination of the Company with
or into another Person (other than (A) a consolidation, merger or other business
combination in which holders of the Company's voting power  immediately prior to
the transaction  continue after the transaction to hold, directly or indirectly,
the  voting  power of the  surviving  entity or  entities  necessary  to elect a
majority of the members of the board of directors (or their  equivalent if other
than a corporation)  of such entity or entities,  or (B) pursuant to a migratory
merger  effected  solely  for  the  purpose  of  changing  the  jurisdiction  of
incorporation of the Company), (ii) the sale or transfer of all or substantially
all of the  Company's  assets,  or (iii) a tender or exchange  offer made to and
accepted by the holders of more than 50% of the  aggregate  voting  power of the
outstanding Common Stock.

(c) Optional Redemption At the Company's Election Upon Cash Transaction.  At any
time or times on or after the date the  Company  publicly  discloses  a pending,
proposed or intended Cash Transaction,  the Company shall have the right, in its
sole discretion,  to require that all, but not less than all, of the Outstanding
Principal  Amount of this Debenture be redeemed  ("Cash  Transaction  Redemption
Election") at a price equal to 100% of the Outstanding  Principal Amount of this
Debenture plus the product of (1) 1.75 and (2) the dollar amount of all Interest
Payments scheduled to be paid following the consummation of the Cash Transaction
and on or prior to the Maturity Date on the total  Outstanding  Principal Amount
of the Debentures  redeemed on the date of consummation of the Cash  Transaction
(the "Cash Transaction  Redemption Price"). The Company shall exercise its right
to make a Cash  Transaction  Redemption  Election  by  providing  each holder of
Debentures written notice ("Notice of Cash Transaction Redemption") by facsimile
or overnight  courier,  after the public  disclosure  of a proposed,  pending or
intended Cash  Transaction and at least ten (10) Business Days prior to the date
of consummation of the Cash Transaction ("Cash Transaction  Election  Redemption
Date"), which Cash Transaction Election Redemption Date shall be the date of the
consummation of the Cash Transaction.  The Notice of Cash Transaction Redemption
shall indicate the anticipated Cash Transaction Election Redemption Date. If the
Company has exercised its right of Cash Transaction Redemption Election then the
Outstanding Principal Amount of the Debenture at the time of the consummation of
the  Cash  Transaction  shall  be  redeemed  on the  Cash  Transaction  Election
Redemption  Date by  payment by or on behalf of the  Company  to each  holder of
Debentures of the applicable Cash  Transaction  Redemption Price concurrent with
the closing of the Cash Transaction.  All holders of Debentures shall thereupon,
if the Cash Transaction  Redemption Price has been paid,  except as specifically
set forth herein,  in the Securities  Purchase  Agreement or in the Registration
Rights  Agreement,  cease to have any rights with respect to the  Debentures and
within two (2)  Business  Days after the Cash  Transaction  Election  Redemption
Date, or such earlier date as the Company and holders of no less then 60% of the
Outstanding  Principal Amount of the Debentures  issued on the Original Issuance
Date mutually agree, shall surrender all Debentures to the Company.

(d) Right to Convert on an Organic  Change or Change of Control or  Agreement of
the Parties.  In addition to the foregoing,  following the  announcement  of any
Change of Control or other Organic Change following which the Company is not the
surviving  entity or  otherwise  upon the mutual  agreement  of the  Company and
holders of at least 60% of the  Outstanding  Principal  Amount of all Debentures
issued on the Original  Issuance  Date,  the Holder shall  continue  pursuant to
Section  4(a)  hereof to have the right to  convert  the  Outstanding  Principal
Amount  of this  Debenture  at the then  prevailing  Conversion  Rate  until the
Debenture is redeemed or otherwise converted pursuant to this Section 7.

8. Reservation of Stock Issuable Upon Conversion.  The Company shall, so long as
any of the Debentures are outstanding,  take all action necessary to reserve and
keep available out of its authorized and unissued  Common Stock,  solely for the
purpose of effecting the conversions of the Debentures, such number of shares of
Common Stock as shall from time to time be sufficient  to effect the  conversion
of all of the Debentures then outstanding; provided that the number of shares of
Common  Stock  so  reserved  shall at no time  prior  to the date on which  cash
collateral  payments have been made pursuant to Section 25 in an amount equal to
the entire  Outstanding  Principal  Amount,  together  with  accrued  and unpaid
interest on all Debentures outstanding be less than 135% of the number of shares
of Common Stock needed to provide for the issuance of the shares of Common Stock
upon  conversion of all of the Debentures  (without regard to any limitations on
conversion)  and the maximum  number of Interest  Shares  issuable over the full
term of the Debentures (assuming the Company paid the maximum amount of interest
permitted  to be paid in Interest  Shares over the full term of the  Debentures)
and  after  such time 100% of the  number  of shares of Common  Stock  needed to
provide for the issuance of the shares of Common Stock upon conversion of all of
the Debentures (without regard to any limitations on conversion).

9. No Reissuance of Debentures.  No Debentures acquired by the Company by reason
of redemption, purchase, conversion or otherwise shall be reissued, and all such
Debentures shall be retired. No additional Debentures (other than the Debentures
issued  pursuant to the Securities  Purchase  Agreement)  shall be authorized or
issued  without the  consent of the  holders of at least 60% of the  Outstanding
Principal Amount of the Debentures issued on the Original Issuance Date.

10. No  Impairment.  The Company shall not  intentionally  take any action which
would impair the rights and privileges of the Debentures set forth herein or the
Holders thereof.

11. Limitation on Beneficial  Ownership.  The Company shall not effect and shall
have no obligation  to effect any  conversion  of  Debentures,  and no holder of
Debentures  shall have the right to convert any  Debentures,  to the extent that
after giving  effect to such  conversion,  the  beneficial  owner of such shares
(together with such Person's affiliates) would have acquired, through conversion
of Debentures or otherwise, beneficial ownership of a number of shares of Common
Stock that  exceeds  4.99% of the number of shares of Common  Stock  outstanding
immediately  after  giving  effect  to  such  conversion.  For  purposes  of the
foregoing sentence, the number of shares of Common Stock beneficially owned by a
Person and its  affiliates  shall  include the number of shares of Common  Stock
issuable  upon   conversion  of  the  Debentures   with  respect  to  which  the
determination  of such  sentence is being made,  but shall exclude the number of
shares of Common  Stock  which  would be  issuable  upon (A)  conversion  of the
remaining,  nonconverted  Debentures beneficially owned by such Person or any of
its affiliates and (B) exercise or conversion of the  unexercised or unconverted
portion of any other securities of the Company  (including,  without limitation,
any warrants) subject to a limitation on conversion or exercise analogous to the
limitation  contained  herein  beneficially  owned by such  Person or any of its
affiliates.  Except as set forth in the preceding sentence, for purposes of this
Section 11, beneficial  ownership shall be calculated in accordance with Section
13(d) of the Securities  Exchange Act of 1934, as amended.  For purposes of this
Section 11, in determining  the number of outstanding  shares of Common Stock, a
holder may rely on the number of outstanding shares of Common Stock as reflected
in (1) the  Company's  most recent Form 10-Q,  Form 10-K or other public  filing
with the SEC, as the case may be, (2) a more recent public  announcement  by the
Company,  or (3) any other notice by the Company or its transfer  agent  setting
forth the number of shares of Common Stock outstanding. Upon the written request
of the Holder,  the Company shall  promptly,  but in no event later than two (2)
Business Days  following  the receipt of such notice,  confirm in writing to the
Holder the number of shares of Common Stock then  outstanding.  In any case, the
number of  outstanding  shares of Common Stock shall be determined  after giving
effect to conversions  of Debentures by the Holder and its affiliates  since the
date as of which such number of outstanding shares of Common Stock was reported.

12. Obligations  Absolute.  No provision of this Debenture shall alter or impair
the obligation of the Company,  which is absolute and unconditional,  to pay the
principal of, and interest on, this  Debenture at the time,  place and rate, and
in the manner, herein prescribed.

13. Waivers of Demand,  Etc. The Company hereby  expressly waives (to the extent
permitted by  applicable  law) demand and  presentment  for  payment,  notice of
nonpayment,   protest,  notice  of  protest,  notice  of  dishonor,   notice  of
acceleration  or intent to accelerate,  bringing of suit and diligence in taking
any action to collect  amounts  called for  hereunder  and will be directly  and
primarily  liable  for the  payment  of all sums  owing and to be owing  hereon,
regardless  of and  without any  notice,  diligence,  act or omission as or with
respect to the collection of any amount called for hereunder.

14.  Replacement  Debentures.  In the event that any Holder notifies the Company
that  its  Debenture(s)  have  been  lost,  stolen  or  destroyed,   replacement
Debenture(s)  identical in all respects to the original Debenture(s) (except for
registration  number and Outstanding  Principal  Amount,  if different than that
shown on the  original  Debenture(s))  shall be  issued  by the  Company  to the
Holder,  provided  that the  Holder  executes  and  delivers  to the  Company an
agreement  reasonably  satisfactory to the Company to indemnify the Company from
any loss incurred by it in connection with such Debenture(s).

         14A.  Payment of  Expenses.  The Company  agrees to pay all  reasonable
expenses,  including  reasonable  attorneys'  fees, which may be incurred by the
Holder  in  successfully  enforcing  the  provisions  of this  Debenture  and/or
successfully  collecting  any amount due under this  Debenture,  the  Securities
Purchase Agreement,  the Security  Agreement,  the Account Control Agreement (as
defined in the Securities Purchase  Agreement),  the Warrants,  the Registration
Rights Agreement or any other Transaction Document.

15.      Defaults.  The following shall constitute "Events of Default":
         --------

(a)      Any Event of Default under any other Debenture; or

(b) The  suspension  from trading or failure of the Common Stock to be listed on
NASDAQ,  the ASE or the NYSE for more than an aggregate of ten (10) trading days
in any 365-day period; or

(c) Any money judgment  (including any arbitration award, but only if reduced to
a judgment),  writ or warrant of attachment, or similar process in excess of Two
Hundred and Fifty  Thousand  Dollars  ($250,000)  in the  aggregate,  net of any
applicable  insurance  coverage,  shall be entered or filed against the Company,
its  Subsidiaries  or any of their  properties  or other  assets and which shall
remain  unpaid,  unvacated,  unbonded and unstayed for a period of  seventy-five
(75) days; or

(d) The  Company  shall  default in the  payment  when due  (including,  without
limitation,  the  Company's  failure to pay any  redemption  payments or amounts
hereunder) of (i) interest on this  Debenture,  and such default shall  continue
for  thirty  (30)  calendar  days  after  the due  date  thereof,  or  (ii)  the
Outstanding Principal Amount of this Debenture; or

(e)  Any of the  representations  or  warranties  made  by  the  Company  herein
(including any Cash Collateral  Certificate delivered under Section 25(g)(iii)),
in the Securities Purchase Agreement,  the Warrants, the Security Agreement, the
Account Control Agreement,  any Mortgage,  the Registration  Rights Agreement or
any other  Transaction  Document shall be untrue in any material  respect at the
time made and such  condition  (to the  extent  capable  of being  cured)  shall
continue  uncured for a period of ten (10)  Business  Days after notice from the
Holder of such  condition;  and such breach of  representations  and warranties,
singly or in the aggregate,  would have a Material  Adverse Effect or materially
impair the ability of the Company to perform or satisfy its  obligations  to the
Holder pursuant to the Transaction Documents; or

(f) The  Company  shall fail to perform or observe in any  material  respect any
material  covenant  or  agreement  in the  Securities  Purchase  Agreement,  the
Security Agreement,  the Warrants,  any Mortgage, the Account Control Agreement,
the  Registration  Rights  Agreement,  this  Debenture or any other  Transaction
Document, including, without limitation, (i) the failure to honor any Conversion
Notice and deliver  shares  pursuant  thereto,  and such failure shall  continue
uncured for a period of ten (10)  Business  Days after notice from the Holder of
such  failure or (ii) the failure by the Company to comply with its  obligations
under Section 25(g) hereof, including, without limitation, (A) the obligation to
disclose  sufficient  and timely  information in its public filings with the SEC
for the holder to verify and  reconcile  Company  Consolidated  Revenues for the
relevant periods, as required by Section 25(g)(iv) hereof, (B) the obligation to
make  payments  timely as and when due and in the form of cash and/or  Repayment
Shares as provided thereunder,  (C) the failure of the Company to deliver timely
a  completed  Cash  Collateral  Certificate  in the manner  required  by Section
25(g)(v)  hereof and (D) the delivery by or on behalf of the Company of any Cash
Collateral  Certificate  to any holder of  Debentures  without the express prior
written consent of such holder; or

(g) The Company shall (i) become insolvent;  (ii) admit in writing its inability
to pay its debts  generally as they  mature;  (iii) make an  assignment  for the
benefit of creditors or commence proceedings for its dissolution;  or (iv) apply
for or consent to the appointment of a trustee, liquidator or receiver for it or
for a substantial part of its property or business; or

(h) A trustee,  liquidator or receiver shall be appointed for the Company or for
a substantial part of its property or business without its consent and shall not
be discharged within sixty (60) days after such appointment; or

(i) Any  governmental  agency  or any  court of  competent  jurisdiction  at the
instance of any governmental agency shall assume custody or control of the whole
or any substantial  portion of the properties or assets of the Company and shall
not be dismissed within sixty (60) days thereafter; or

(j) The Company  shall fail to pay any debt for borrowed  money or other similar
obligation or liability  ("Indebtedness")  (excluding  Indebtedness evidenced by
the Debentures,  Subordinated  Indebtedness and Pari Passu  Indebtedness) of the
Company,  or any  interest or premium  thereon,  when due  (whether by scheduled
maturity,  required  prepayment,  acceleration,  demand  or  otherwise),  in  an
outstanding  principal  amount  equal to or in  excess  of One  Million  Dollars
($1,000,000),  singly or in the aggregate and such failure shall  continue after
the applicable  grace period,  if any,  specified in the agreement or instrument
relating to such Indebtedness,  or any such Indebtedness of the Company shall be
declared  to be due and  payable,  or  required  to be prepaid  (other than by a
regularly scheduled required prepayment),  prior to the stated maturity thereof;
or

(k) The  Company  shall  fail to make any  payment  of  principal  in respect of
Subordinated  Indebtedness or Pari Passu Indebtedness or any interest or premium
thereon,   when  due  (whether  by  scheduled  maturity,   required  prepayment,
acceleration,  demand or  otherwise),  and such failure shall continue after the
applicable  grace  period,  if any,  specified in the  agreement  or  instrument
relating to such Subordinated  Indebtedness or Pari Passu  Indebtedness,  or any
such Subordinated  Indebtedness or Pari Passu  Indebtedness shall be declared to
be due and  payable,  or  required  to be  prepaid  (other  than by a  regularly
scheduled required prepayment), prior to the stated maturity thereof; or

(l) Bankruptcy,  reorganization,  insolvency or liquidation proceedings or other
similar  proceedings,  or relief under any bankruptcy law or any similar law for
the relief of debt  shall be  instituted  by or  against  the  Company  and,  if
instituted  against the Company,  shall not be dismissed  within sixty (60) days
after such  institution or the Company shall by any action or answer approve of,
consent  to,  or  acquiesce  in any such  proceedings  or admit to any  material
allegations of, or default in answering a petition filed in any such proceeding;
or

(m) Unless the  Company  shall have made cash  collateral  payments in an amount
equal to the entire  Outstanding  Principal  Amount of all Debentures,  together
with accrued and unpaid interest thereon,  in accordance with Section 25(g), the
Registration  Statement (as defined in the Registration Rights Agreement) is not
declared  effective by the SEC and available for the sale of at least all of the
Registrable Securities (as defined in the Registration Rights Agreement pursuant
to the terms of the Registration  Rights  Agreement)  required to be included in
such Registration Statement on or before July 26, 2004; or

(n) the Security Agreement,  any Mortgage (as defined in the Securities Purchase
Agreement) or any other security  document,  after delivery  thereof pursuant to
the Securities Purchase Agreement,  shall for any reason fail or cease to create
a valid and perfected and, except to the extent permitted by the terms hereof or
thereof,  first  priority  lien in favor of the  agent  for the  benefit  of the
holders of Debentures on any collateral purported to be covered thereby; or

(o) the Cash Collateral  Account Bank shall fail to comply with any of the terms
of the Account Control Agreement;

(p) at any time  required  to be in full force and effect  under the  Securities
Purchase  Agreement,  the Letters of Credit  shall for any reason cease to be in
full force and effect other than in  accordance  with their express terms or any
issuer of any of the Letters of Credit  shall fail to maintain a Minimum  Rating
(as  defined  in the  Securities  Purchase  Agreement)  or fail to  perform  its
obligations  thereunder  or shall,  in writing,  repudiate  the Letter of Credit
issued by it or deny that its  obligations  thereunder  are valid,  binding  and
enforceable,  and such failure  shall  continue  uncured for a period of fifteen
(15) days after notice from the Holder of such failure;

(q) the report of the Company's auditors on the Company's  consolidated  audited
financial  statements  for the year ended December 31, 2003 shall have contained
any going concern qualification; or

(r) any material  damage to, or loss,  theft or destruction  of, any Collateral,
whether  or not  insured,  or  any  strike,  lockout,  labor  dispute,  embargo,
condemnation,  act of God or public enemy,  or other casualty which causes,  for
more  than  fifteen  (15)   consecutive   days,  the  cessation  or  substantial
curtailment  of revenue  producing  activities  at any material  facility of the
Company or any of its Subsidiaries.

Unless an Event of  Default  shall  have been  waived in  writing  by the Holder
(which  waiver  shall not be deemed to be a waiver of any  subsequent  default),
upon the  occurrence  of an Event of  Default,  and for so long as such Event of
Default shall be continuing, at the option of and on notice by the Holder to the
Company in writing and in the Holder's sole discretion,  the Holder may consider
this Debenture immediately due and payable, without presentment, demand, protest
or notice of any kind, all of which are hereby expressly waived, anything herein
or in any other  instruments  contained to the contrary  notwithstanding  to the
extent permitted by applicable law (provided,  however, that upon the occurrence
of any Event of Default  described in subsection (g), (h) or (l) above,  without
any notice to the Company or any act by the Holder or the Agent,  this Debenture
shall become due and payable automatically and immediately, without presentment,
demand,  protest or notice of any kind, all of which are expressly waived by the
Company,  anything herein or in any other  instrument  contained to the contrary
notwithstanding  to the extent  permitted by applicable law), and the Holder may
immediately,  and without expiration of any further period of grace, enforce any
and all of the  Holder's  rights  and  remedies  provided  herein,  or under the
Security Agreement, the Mortgages, the Account Control Agreement and the Letters
of Credit or any other  rights or  remedies  afforded by law. In such event this
Debenture  shall  be  redeemed  at a  redemption  price  equal  to  100%  of the
Outstanding Principal Amount of the Debenture,  plus accrued and unpaid interest
on this Debenture.  In addition to the foregoing,  upon an Event of Default, the
rate of interest on this Debenture,  shall, to the maximum extent of the law, be
permanently  increased by two percent  (2%) per annum  (i.e.,  from 7% to 9% per
annum)  commencing  on the  first day of the  thirty  (30) day  period  (or part
thereof) following the Event of Default;  and, solely in the case of an Event of
Default  triggered by a Conversion  Failure,  an additional two percent (2%) per
annum  commencing  on the first day of each of the second and third such  thirty
(30) day periods (or part  thereof);  and an additional  one percent (1%) on the
first  day of  each  consecutive  thirty  (30)  day  period  (or  part  thereof)
thereafter  until this  Debenture has been duly  converted or redeemed as herein
provided;  provided that in no event shall the rate of interest exceed the lower
of 20% or the highest rate permitted by applicable law. The Company shall within
one (1) Business Day notify each Holder of Debentures upon becoming aware of the
occurrence of any Event of Default (whether or not waived by any other Holder of
Debentures)  or of any action taken by any Holder of Debentures  with respect to
the occurrence of any Event of Default.

16. Savings  Clause.  In case any provision of this Debenture is held by a court
of competent  jurisdiction  to be  excessive  in scope or  otherwise  invalid or
unenforceable, such provision shall be adjusted rather than voided, if possible,
so that it is enforceable to the maximum extent  possible,  and the validity and
enforceability of the remaining provisions of this Debenture will not in any way
be affected or impaired thereby.

17. Entire  Agreement.  This  Debenture and the  agreements  referred to in this
Debenture constitute the full and entire understanding and agreement between the
Company  and the  Holder  with  respect  to the  subject  hereof.  Neither  this
Debenture nor any term hereof may be amended,  waived,  discharged or terminated
other than by a written instrument signed by the Company and the Holder.

18.  Assignment,  Etc. The Holder may, subject to compliance with the Securities
Purchase Agreement and to applicable federal and state securities laws, transfer
or assign  this  Debenture  or any portion  thereof and may pledge,  encumber or
transfer  its rights or interest in and to this  Debenture  or any part  hereof,
provided,  that such transfer or assignment of this Debenture does not result in
more than ten (10)  holders  of the total  Outstanding  Principal  Amount of all
Debentures and any such part or portion of this  Debenture  constitutes at least
10% of the Outstanding  Principal  Amount or such lesser amount if such transfer
involves the entire  Outstanding  Principal Amount then held by such transferor.
Any such  transfer or  assignment  shall only be  effective  upon the  Company's
receipt of written notice  thereof.  Each such assignee,  transferee and pledgee
shall have all of the rights of the Holder  under this  Debenture.  The  Company
agrees that, subject to compliance with the Securities Purchase Agreement, after
receipt by the Company of written  notice of assignment  from the Holder and the
Holder's assignee, all principal, interest and other amounts which are then, and
thereafter  become,  due under this  Debenture  shall be paid to such  assignee,
transferee or pledgee at the place of payment  designated  in such notice.  This
Debenture  shall be binding upon the Company and its  successors and shall inure
to the benefit of the Holder and its successors and registered assigns.

19. No Waiver. No failure on the part of the Holder to exercise, and no delay in
exercising,  any  right,  remedy or power  hereunder  shall  operate as a waiver
thereof,  nor shall any single or partial  exercise  by the Holder of any right,
remedy or power  hereunder  preclude  any other or future  exercise of any other
right,  remedy or power. Each and every right, remedy or power hereby granted to
the Holder or allowed it by law or other  agreement  shall be cumulative and not
exclusive of any other, and may be exercised by the Holder from time to time.

20. Notices. Unless otherwise provided herein, any notices, consents, waivers or
other  communications  required or permitted to be given under the terms of this
Debenture must be in writing and will be deemed to have been delivered: (i) upon
receipt,  when delivered  personally;  (ii) upon receipt, when sent by facsimile
(provided   confirmation  of  transmission  is  mechanically  or  electronically
generated and kept on file by the sending party);  or (iii) one (1) Business Day
after deposit with a nationally  recognized  overnight delivery service, in each
case  properly  addressed to the party to receive the same.  The  addresses  and
facsimile numbers for such communications shall be:

                           If to the Company:

                                    Hemispherx Biopharma, Inc.
                                    1617 JFK Boulevard
                                    Suite 660
                                    Philadelphia, PA 19103
                                    Telephone:       (215) 998-8000
                                    Facsimile:       (215) 998-1739
                                    Attention:       Chief Executive Officer

                           With a copy to:

                                    Ransom W. Etheridge, Esq.
                                    2610 Potters Road
                                    Suite 200
                                    Virginia Beach, VA  23452
                                    Telephone:       (757-486-0599
                                    Facsimile:       (757) 486-0792


                  If to a holder,  to its address and facsimile number set forth
on the Schedule of Buyers attached to the Securities  Purchase  Agreement,  with
copies to such holder's  representatives as set forth on the Schedule of Buyers,
or to such other address and/or facsimile number and/or to the attention of such
other person as the  recipient  party has  specified by written  notice given to
each  other  party  five (5) days  prior to the  effectiveness  of such  change.
Written  confirmation  of receipt  (A) given by the  recipient  of such  notice,
consent,  waiver or other  communication,  (B)  mechanically  or  electronically
generated by the sender's facsimile machine containing the time, date, recipient
facsimile  number  and an image of the first  page of such  transmission  or (C)
provided by a courier or overnight courier service shall be rebuttable  evidence
of  personal  service,  receipt  by  facsimile  or  receipt  from  a  nationally
recognized  overnight  delivery  service in accordance  with clause (i), (ii) or
(iii) above, respectively.

21. Miscellaneous.  Whenever the sense of this Debenture requires,  words in the
singular  shall be deemed to include the plural and words in the plural shall be
deemed to include the singular.  Paragraph headings are for convenience only and
shall not affect the meaning of this document.

22.  Choice of Law and Venue;  Waiver of Jury  Trial.  THIS  DEBENTURE  SHALL BE
CONSTRUED  UNDER THE LAWS OF THE STATE OF NEW YORK WITHOUT  REGARD TO PRINCIPLES
OF CONFLICTS OF LAW OR CHOICE OF LAW (OTHER THAN SECTION  5-1401 OF THE NEW YORK
GENERAL  OBLIGATIONS  LAW).  The parties hereto hereby agree that all actions or
proceedings  arising  directly or  indirectly  from or in  connection  with this
Debenture  shall be litigated only in the Supreme Court of the State of New York
or the  United  States  District  Court for the  Southern  District  of New York
located  in New York  County,  New  York.  The  parties  hereto  consent  to the
jurisdiction  and venue of the foregoing  courts and consent that any process or
notice  of  motion or other  application  to  either  of said  courts or a judge
thereof may be served  inside or outside  the State of New York or the  Southern
District of New York by registered mail, return receipt  requested,  directed as
provided in Section 20 (and  service so made shall be deemed  complete  five (5)
days after the same has been posted as aforesaid)  or by personal  service or in
such other  manner as may be  permissible  under the rules of said  courts.  The
parties  hereto  hereby waive any right to a jury trial in  connection  with any
litigation pursuant to this Debenture.

23. Rule 144. With a view to making available to the Holder the benefits of Rule
144  promulgated  under the Act ("Rule 144") and any other rule or regulation of
the SEC that may at any time permit the Holder to sell the  underlying  stock of
the Company  issuable  upon  conversion  or exercise of the  Debentures  and the
Warrants  to the public  without  registration,  the  Company  agrees to use its
reasonable best efforts to:

(a) make and keep public  information  available,  as those terms are understood
and defined in Rule 144, at all times;

(b)  file  with the SEC in a timely  manner  all  reports  and  other  documents
required of the Company under the Act and the  Securities  Exchange Act of 1934,
as amended (the "Exchange Act"); and

(c) furnish to any Holder,  promptly  upon request,  a written  statement by the
Company  (provided  true at the time) that it has complied  with the  applicable
reporting and filing requirements of the Act and the Exchange Act, a copy of the
most recent annual or quarterly report of the Company,  and copies of such other
reports  and  documents  (if any) so filed by the  Company as may be  reasonably
requested to permit any such Holder to take  advantage of any rule or regulation
of the SEC permitting the selling of any such securities without registration.

         24.  Company Installment Conversion or Redemption.
              --------------------------------------------

(a) General. On each Installment Date (unless waived by the Holder), the Company
shall  pay to the  Holder  of  this  Note  the  Installment  Amount  as of  such
Installment Date by the combination of any of the following,  but subject to and
in accordance with the terms of this Section 24, (i) requiring the conversion of
a  portion  of the  applicable  Installment  Amount,  in whole  or in  part,  in
accordance  with  this  Section  24  but  subject  to  the  satisfaction  of the
Conditions to Company  Conversion (as defined  below) (a "Company  Conversion"),
and/or (ii) redeeming the applicable Installment Amount, in whole or in part, in
accordance with this Section 24 (a "Company  Redemption");  provided that all of
the outstanding  applicable  Installment Amount as of each such Installment Date
must be converted  and/or redeemed by the Company on the applicable  Installment
Date,  subject to the  provisions  of this  Section  24. On or prior to the date
which is at least 2 Trading Days prior to each Installment Measuring Period, the
Company shall deliver written notice to the Holder (each, a "Company Installment
Notice"),  which Company Installment Notice shall state (i) the portion, if any,
of the  applicable  Installment  Amount  which the  Company  elects  to  convert
pursuant  to a  Company  Conversion,  which  amount  when  added to the  Company
Redemption  Amount,  if any, must equal the applicable  Installment  Amount (the
"Company  Conversion  Amount"),  (ii) the  portion,  if any,  of the  applicable
Installment  Amount  which the  Company  elects to redeem  pursuant to a Company
Redemption  (the "Company  Redemption  Amount"),  which amount when added to the
Company Conversion Amount, if any, must equal the applicable Installment Amount,
and (iii) if the Company has elected, in whole or in part, a Company Conversion,
then the Company Installment Notice shall certify that the Conditions to Company
Conversion are satisfied as of the date of the Company  Installment  Notice.  If
the Company does not deliver a Company  Installment  Notice in  accordance  with
this  Section  24(a),  then the  "Company  Redemption  Amount" and the  "Company
Conversion  Amount"  with  respect  to such  Installment  Date  shall be in such
amounts and  proportions as the Holder shall designate in writing to the Company
in its sole  discretion  and the  Company  shall be deemed to have  delivered  a
Company Installment Notice setting forth such amounts.  Each Company Installment
Notice shall be irrevocable. Except as expressly provided in this Section 24(a),
the Company shall redeem and convert the applicable  Installment  Amount of this
Debenture pursuant to this Section 24 and the corresponding  Installment Amounts
of the other Debentures  pursuant to the  corresponding  provisions of the other
Debentures  in the same  ratio of the  Installment  Amount  being  redeemed  and
converted  hereunder.  The Company  Redemption  Amount (whether set forth in the
Company Installment Notice or by operation of this Section 24) shall be redeemed
in accordance  with Section 24(b),  and the Company  Conversion  Amount shall be
converted in accordance with Section 24(c).

(b) Mechanics of Company Redemption. If the Company elects, or is deemed to have
elected, a Company Redemption in accordance with Section 24(a), then the Company
Redemption  Amount,  if any, which is to be paid to the Holder on the applicable
Installment Date shall be redeemed by the Company on such Installment  Date, and
the Company shall pay to the Holder on such  Installment  Date, by wire transfer
of  immediately  available  funds,  an amount in cash (the "Company  Installment
Redemption  Price") equal to the sum of 100% of the Company  Redemption  Amount.
Notwithstanding  anything to the contrary in this Section 24(b),  but subject to
Sections 11 and 26, until the Company  Installment  Redemption  Price  (together
with any  interest  thereon)  is paid in full,  the  Company  Redemption  Amount
(together with any interest thereon to the extent permitted in this Debenture to
be paid by the Company in Common Stock) may be  converted,  in whole or in part,
by the Holder into Common Stock pursuant to Section 4.

(c) Mechanics of Company  Conversion.  Subject to Sections 11 and 26 and Section
24(e),  if the Company  delivers a Company  Installment  Notice and elects or is
deemed to have elected,  in whole or in part, a Company Conversion in accordance
with Section 24(a), then the applicable Company Conversion Amount, if any, which
remains outstanding shall be converted as of the applicable  Installment Date by
converting on such  Installment  Date such Company  Conversion  Amount as if the
Holder had delivered a Conversion  Notice  pursuant to Section 4 with respect to
such Company  Conversion  Amount on such Installment Date but without the Holder
being required to actually  deliver such  Conversion  Notice;  provided that the
Conditions  to Company  Conversion  are  satisfied  (or waived in writing by the
Holder) on such  Installment  Date. If the Conditions to Company  Conversion are
not  satisfied  (or waived in writing by the Holder) on such  Installment  Date,
then at the option of the Holder  designated  in  writing  to the  Company,  the
Holder may require the Company to do any one or more of the  following:  (i) the
Company shall redeem all or any part designated by the Holder of the unconverted
Company  Conversion  Amount (such designated amount is referred to as the "First
Redemption  Amount") on such  Installment  Date and the Company shall pay to the
Holder on such  Installment  Date,  by wire  transfer of  immediately  available
funds,  an amount in cash equal to such  First  Redemption  Amount,  or (ii) the
Company  Conversion  shall  be null  and void  with  respect  to all or any part
designated by the Holder of the unconverted  Company  Conversion  Amount and the
Holder shall be entitled to all the rights of a holder of this Note with respect
to such amount of the Company  Conversion Amount. If the Company fails to redeem
any First  Redemption  Amount on the applicable  Installment  Date by payment of
such amount on the applicable  Installment  Date, then the Holder shall have the
rights set forth in Section 24(b) as if the Company failed to pay the applicable
Company  Redemption  Price  and all other  rights  under  this Note  (including,
without limitation,  such failure  constituting an Event of Default described in
Section  15(d)).  In the event the Holder  delivers a  Conversion  Notice to the
Company  after the earlier of the date which is 10 days prior to the  applicable
Installment Date and the Holder's receipt of the Company  Installment  Notice in
respect of such  Installment  Date in which the  Company  elects or is deemed to
have  elected a Company  Redemption,  the  Principal  amount  specified  in such
Conversion Notice shall be deducted (1) first, from the Principal represented by
the Company  Redemption  Amount and then (2) second,  in accordance with Section
4(e)(h).

(d)  Conditions  to  Company  Conversion.  For  purposes  of  this  Section  24,
"Conditions to Company  Conversion" means (i) during the period beginning on the
Original  Issuance Date and ending on and including the  applicable  Installment
Date,  the  Company  shall  have  delivered  shares  of  Common  Stock  upon any
conversion  of  Conversion  Amounts  on a timely  basis as set forth in  Section
4(e)(ii) and analogous  provisions  under the other  Debentures,  and shall have
delivered shares of Common Stock upon exercise of any Warrants on a timely basis
as set forth in Section 2(a) of the Warrants; (ii) on each day during the period
beginning  on the  Original  Issuance  Date  and  ending  on and  including  the
applicable  Installment  Date, the Common Stock shall be listed on the Principal
Market  and  delisting  or  suspension  of the  Common  Stock by such  market or
exchange shall not have been threatened  either (A) in writing by such market or
exchange or (B) by falling below the minimum listing maintenance requirements of
such market or exchange for the Common Stock;  (iii) during the period beginning
on the  Original  Issuance  Date and  ending  on and  including  the  applicable
Installment   Date,  there  shall  not  have  occurred  either  (x)  the  public
announcement of a pending,  proposed or intended Change of Control which has not
been  abandoned,  terminated  or  consummated  or (y) an Event of Default;  (iv)
during the period beginning on the date which is the Original  Issuance Date and
ending on and including the applicable  Installment  Date,  there shall not have
occurred  an event  that  with the  passage  of time or giving  of  notice,  and
assuming it were not cured,  would  constitute an Event of Default;  (v) on each
day of the period  beginning  on the date of delivery  of a Company  Installment
Notice  with  respect  to an  Installment  Date  and  ending  on the  applicable
Installment  Date  either  (x)  the   Registration   Statement  or  Registration
Statements  required  pursuant to the  Registration  Rights  Agreement  shall be
effective and available for the resale of all of the  Registrable  Securities in
accordance  with and to the  extent  required  by the terms of the  Registration
Rights  Agreement or (y) all shares of Common Stock issuable upon  conversion of
the Debentures and shares of Common Stock issuable upon exercise of the Warrants
shall be eligible  for sale  without  restriction  (other  than any  restriction
arising under  applicable  federal or state  securities  laws as a result of the
holder of such  securities  being an  Affiliate  of the Company) and without the
need for  registration  under any applicable  federal or state  securities laws;
(vi) on each day of the period beginning on the applicable  Installment Date and
ending thirty Trading Days  thereafter  either (x) the  Registration  Statements
required  pursuant to the Registration  Rights Agreement shall be expected to be
effective  and  available  for the  resale  of at least  all of the  Registrable
Securities  in  accordance  with and to the extent  required by the terms of the
Registration  Rights  Agreement or (y) all shares of Common Stock  issuable upon
conversion of the  Debentures  and shares of Common Stock issuable upon exercise
of the Warrants shall be eligible for sale without  restriction  (other than any
restriction  arising  under  applicable  federal or state  securities  laws as a
result of the holder of such  securities  states as an Affiliate of the Company)
and  without the need for  registration  under any  applicable  federal or state
securities  laws;  and (vii) the Company  otherwise  shall have been in material
compliance  with and shall  not have  breached,  in any  material  respect,  any
provision,  covenant,  representation  or  warranty of the  Securities  Purchase
Agreement,  any of the  Warrants,  any of  the  Debentures  or any of the  other
Transaction Documents.

(e)  Certain  Definitions.  For  purposes  of this  Section  24,  the  following
capitalized terms shall have the following meanings:

     (i)  "Company   Conversion  Price"  means,  with  respect  to  any  Company
          Conversion,  that  price  which  shall  be  computed  as  95%  of  the
          arithmetic  average of the Weighted  Average Price of the Common Stock
          on each trading day in the Installment Measuring Period.

     (ii) "Installment  Amount" means, with respect to any Installment Date, the
          Outstanding  Principal  Amount of this Debenture as of the Installment
          Date divided by the number of full months between the Installment Date
          and June 30,  2007.  In the event the Holder  shall sell or  otherwise
          transfer  any  portion  of this  Debenture,  the  transferee  shall be
          allocated a pro rata portion of the Installment Amount.

     (iii)"Installment  Date" means each  monthly  anniversary  of the  Original
          Issuance Date, commencing on July 1, 2006.

     (iv) "Installment  Measuring  Period" means, with respect to an Installment
          Date,  the 10-day  trading day period  commencing on and including the
          eleventh  trading day immediately  preceding such Installment Date and
          ending on and including  the trading day  immediately  preceding  such
          Installment Date.

25. Rank; Covenants; Cash Collateral.

     (a) Definitions. For purposes of this Section 25, the following terms shall
have the following meanings:

(i)  "Acquisition  Buildings"  shall mean the buildings  being  purchased by the
Company in connection with the Interferon  Acquisition and located at 783 Jersey
Avenue, 5 Jules Lane, New Brunswick Middlesex Co., New Jersey.

(ii) "Acquisition Indebtedness" shall mean any Indebtedness incurred, assumed or
guaranteed by the Company or any of its  Subsidiaries in respect of the purchase
price for,  or in  connection  with the  purchase  of, any  assets,  business or
securities  (an  "Acquired  Business")  acquired  by the  Company  or any of its
Subsidiaries,  other  than  Indebtedness  incurred,  assumed  or  guaranteed  in
connection with the Interferon Acquisition.

(iii)  "Acquisition  Multiple" shall mean,  subject in all respects to the final
sentence of Section 25(b)(i) hereof,  (i) in the event the Acquired  Business is
not a Qualified  Competitor,  three times the EBITDA of the Acquired Business or
(ii) in the event the Acquired  Business is a Qualified  Competitor,  four times
the EBITDA of the Acquired  Business;  provided,  however,  that if prior to the
closing of the  acquisition of any Acquired  Business under  subsections  (i) or
(ii) of this  definition,  the Company  has not been  furnished  with  financial
statements  of such  Acquired  Business  that have been  audited by a nationally
recognized auditing firm, the Acquisition  Multiple shall be two and one half (2
1/2) times the EBITDA of the Acquired Business.

(iv)  "Biweekly  Revenue  Cash  Collateral  Date"  shall  mean the 15th and last
calendar  day of each month during the Initial Cash  Collateral  Period.  If any
Biweekly  Revenue Cash  Collateral Date is not a Business Day, then the Biweekly
Revenue Cash  Collateral  Date shall be the Business Day  immediately  following
such Biweekly Revenue Cash Collateral Date.

(v) "Cash  Collateral  Date" shall mean each  Biweekly  Revenue Cash  Collateral
Date,  Monthly  Revenue Cash Collateral  Date, the First Revenue  Milestone Cash
Collateral  Date, the Second Revenue  Milestone Cash Collateral  Date, the Third
Revenue Milestone Cash Collateral Date, the Qualified  Inventory  Financing Date
and the Qualified Mortgage Financing Date.

(vi) "Company Consolidated Revenues" shall mean the aggregate amount of all cash
collected by the Company and its Subsidiaries,  including,  without  limitation,
cash  proceeds  from the  sales  of  inventory,  cash  collections  of  accounts
receivable,  cash collections of licensing fees, cash proceeds from the issuance
of  all   Indebtedness   (excluding  cash  received  for  the  purchase  of  the
Debentures),  but excluding cash received from (a) the issuance of any equity or
equity linked securities of the Company,  (b) the Qualified  Mortgage  Financing
and (c) the Qualified Inventory Financing.

(vii)  "EBITDA"  shall mean (1) the  earnings  before  interest,  income  taxes,
depreciation and amortization of the Acquired  Business for the twelve (12) full
months immediately  preceding the closing date in respect of the purchase of the
Acquired  Business less (2) any capital  expenditures  of the Acquired  Business
during such period.

(viii) "First Revenue Milestone Cash Collateral Date" shall mean March 31, 2004.

(ix) "First Revenue Milestone Measuring Period" shall mean the period commencing
on January 1, 2004 and ending on the First  Revenue  Milestone  Cash  Collateral
Date.

(x) "First Revenue Milestone Target" shall mean $800,000.00.

(xi) "Initial Cash  Collateral  Period" shall mean the period  commencing on and
including April 15, 2004 and ending on and including April 29, 2005.

(xii)  "Inventory"  shall  mean,  with  respect  to any  Person,  all  goods and
merchandise of such Person,  including,  without limitation,  all raw materials,
work-in-process,  packaging,  supplies,  materials  and finished  goods of every
nature used or usable in connection with the shipping,  storing,  advertising or
sale of such goods and merchandise, whether now owned or hereafter acquired, and
all such other  property the sale or other  disposition of which would give rise
to an account receivable, including, without limitation, all of the items listed
on Exhibit B to this Debenture.

(xiii) "Lien" shall mean any mortgage, deed of trust, pledge, lien (statutory or
otherwise),  security  interest,  charge or other  encumbrance  or  security  or
preferential  arrangement  of any nature,  including,  without  limitation,  any
conditional sale or title retention  arrangement,  any capitalized lease and any
assignment,  deposit  arrangement or financing  lease intended as, or having the
effect of, security.

(xiv) "Monthly Revenue Cash Collateral Date" shall mean the 30th calendar day of
each month during the Secondary Cash Collateral  Period (except for the month of
January  2005,  which shall be the 31st calendar day of such month and the month
of February, which shall be the 28th calendar day of such month). If any Monthly
Revenue Cash  Collateral  Date is not a Business Day,  then the Monthly  Revenue
Cash  Collateral  Date shall be the  Business  Day  immediately  following  such
Monthly Revenue Cash Collateral Date.

(xv) "Pari Passu  Indebtedness"  shall mean  Indebtedness that is made expressly
"pari passu" in right of payment with the  Debentures  in an aggregate of (i) up
to an aggregate  principal amount of $5,000,000 of  Indebtedness,  (ii) up to an
additional aggregate principal amount of $5,000,000 of Indebtedness  incurred at
any time after the eighteen  (18) month  anniversary  of the  Original  Issuance
Date,  provided that in order to incur any Pari Passu  Indebtedness  pursuant to
this clause (ii) the  arithmetic  average of the Weighted  Average  Price of the
Common  Stock on each  trading  day during the twenty  consecutive  trading  day
period prior to the  incurrence of any such Pari Passu  Indebtedness  under this
clause  (ii) must equal or exceed 150% of the  Conversion  Price then in effect,
(iii)  up  to  an  additional   aggregate  principal  amount  of  $4,000,000  of
Indebtedness  incurred any time after the  Outstanding  Principal  Amount of all
Debentures is less than  $1,000,000;  provided,  that in order to incur any Pari
Passu  Indebtedness  under  this  clause  (iii) the  arithmetic  average  of the
Weighted Average Price of the Common Stock on each trading day during the twenty
consecutive  trading day period prior to the  incurrence  of any such Pari Passu
Indebtedness under this clause (iii) must equal or exceed 150% of the Conversion
Price  then  in  effect  (iv)  Acquisition  Indebtedness,   and  (v)  any  other
indebtedness  of the Company  which the Company and the holders of more than 60%
of the  then  Outstanding  Principal  Amount  of the  Debentures  issued  on the
Original   Issuance  Date  may  hereafter   from  time  to  time  expressly  and
specifically agree in writing shall constitute Pari Passu Indebtedness.

(xvi)    "Permitted Liens" shall mean:

     (A)  Liens securing all obligations under the Debentures and the agreements
          and instruments entered into in connection therewith;

     (B)  the Qualified Mortgage;

     (C)  the Qualified Inventory Liens;

     (D)  Liens  on  any  Intellectual  Property  of the  Company  or any of its
          Subsidiaries; and

(E) Liens securing all obligations under the Company's Series A and Serieis C 7%
Senior Secured  Convertible  Debentures Due June 30, 2007 and the agreements and
instruments entered into in connection therewith.


(xvii)   "Qualified   Competitor"  shall  mean  an  Acquired  Business  that  is
competitive  with and in the same business with a business of the Company or any
of its Subsidiaries,  where the Company's Board of Directors determines,  in its
reasonable  judgment,  that  substantially all overhead expenses of the Acquired
Business during the trailing twelve months immediately preceding the acquisition
of such Acquired  Business are duplicative with overhead expenses of the Company
or any of such  Subsidiaries  and such  duplicative  expenses will be eliminated
within  six (6)  months  immediately  following  the  purchase  of the  Acquired
Business.

(xviii) "Qualified  Indebtedness" shall mean Pari Passu Indebtedness that is not
evidenced by any certificate, instrument, note or other agreement that, directly
or indirectly,  permits or requires such  Indebtedness to be convertible into or
exercisable  or  exchangeable  for Common  Stock (other than Options that may be
issued by the Company to the holder(s) of such Indebtedness,  the value of which
does not exceed 10% of the  principal  amount of  Indebtedness  so incurred,  as
determined using the Black-Scholes valuation methodology).

(xix) "Qualified Inventory Financing" shall mean a single financing  arrangement
pursuant to which the Company and/or its Subsidiaries  obtains  financing solely
through the  granting of Liens on  Inventory  that yield total net  unrestricted
cash  proceeds to the  Company at the time of the  creation of such Liens of not
less than $2,000,000.00.

(xx)  "Qualified  Inventory  Financing  Date"  shall  mean the date on which the
Qualified Inventory Financing is consummated.

(xxi) "Qualified Inventory Liens" shall mean Liens on Inventory that are created
or imposed solely in connection with a Qualified Inventory Financing.

(xxii) "Qualified  Mortgage" shall mean a mortgage on the Acquisition  Buildings
that is  created or  imposed  solely in  connection  with a  Qualified  Mortgage
Financing.

(xxiii) "Qualified Mortgage Financing" shall mean a single financing arrangement
pursuant to which the Company  either (i) obtains  financing  solely through the
granting of Liens on the  Acquisition  Buildings  or (ii) sells the  Acquisition
Building,  in each case in a transaction that yields total net unrestricted cash
proceeds to the Company at the time of the creation of such Liens or at the time
of such sale, as applicable, of not less than $1,500,000.00.

(xxiv)  "Qualified  Mortgage  Financing  Date"  shall mean the date on which the
Qualified Mortgage Financing is consummated.

(xxv) "Secondary Cash Collateral Period" shall mean the period commencing on and
including April 30, 2005 and ending on and including the Maturity Date.

(xxvi) "Second Revenue Milestone Cash Collateral Date" shall mean June 30, 2004;
provided  that if such  day is not a  Business  Day,  then  the  Second  Revenue
Milestone Cash Collateral  Date shall be the Business Day immediately  following
the Second Revenue Milestone Cash Collateral Date.

(xxvii)  "Second  Revenue  Milestone  Measuring  Period"  shall  mean the period
commencing on January 1, 2004 and ending on the Second  Revenue  Milestone  Cash
Collateral Date.

(xxviii) "Second Revenue Milestone Target" shall mean $1,500,000.00.

(xxix) "Third  Revenue  Milestone Cash  Collateral  Date" shall mean December 31
2004;  provided  that if such day is not a Business  Day, then the Third Revenue
Milestone Cash Collateral  Date shall be the Business Day immediately  following
the Third Revenue Milestone Cash Collateral Date.

(xxx)  "Third  Revenue  Milestone   Measuring  Period"  shall  mean  the  period
commencing  on January 1, 2004 and ending on the Third  Revenue  Milestone  Cash
Collateral Date.

(xxxi)   "Third Revenue Milestone Target" shall mean $3,000,000.00.

     (b) Incurrence of Indebtedness.


(i) So  long  as any of the  Debentures  are  outstanding  and  cash  collateral
payments  have not  been  made in an  amount  equal  to the  entire  Outstanding
Principal  Amount and accrued and unpaid interest on all Debentures  pursuant to
Section  25(g),  the Company  shall not, and the Company shall not permit any of
its  Subsidiaries  to,  directly or  indirectly,  incur or guarantee,  assume or
suffer to exist any Indebtedness,  other than (A) the Indebtedness  evidenced by
the  Debentures  which shall rank ratably and equally with each other,  (B) Pari
Passu  Indebtedness  that is not  secured by any assets of the Company or any of
its  Subsidiaries  and that does not  provide at any time for the payment of any
principal  thereon  until  at  least  91 days  after  the  Maturity  Date of the
Debentures (except for the payment of principal on Qualified Indebtedness to the
extent permitted under Section 25(e)(ii)), (C) Indebtedness represented by trade
payables  incurred  by the  Company  in the  ordinary  course of  business,  (D)
Indebtedness  incurred  in  connection  with a  Qualified  Inventory  Financing,
provided that the proceeds of such Qualified  Inventory Financing are applied to
make cash  collateral  payments  on the  Debentures  in the manner  provided  in
Section  25(g)(i)(F)  hereof,  (E)  Indebtedness  incurred in connection  with a
Qualified  Mortgage  Financing,  provided  that the  proceeds of such  Qualified
Mortgage  Financing  are  applied  to  make  cash  collateral  payments  on  the
Debentures  in  the  manner  provided  in  Section   25(g)(i)(G)   hereof,   (F)
Indebtedness that is not secured by any assets or property of the Company or any
of its  Subsidiaries,  is made expressly  subordinate in right of payment to the
Debentures  and  that  does not  provide  at any  time  for the  payment  of any
principal  thereon  until  at  least  91 days  after  the  Maturity  Date of the
Debentures  ("Subordinated  Indebtedness") pursuant to a subordination agreement
containing the provisions attached hereto as Exhibit A executed and delivered by
the  Company  and any  holder of  Subordinated  Indebtedness  to each  holder of
Debentures  as  a  condition  to  the  incurrence  of  such  Indebtedness,   (G)
Indebtedness  incurred,  assumed or guaranteed in connection with the Interferon
Acquisition, and (H) Indebtedness relating to the Company's Series A and/or C 7%
Senior  Secured  Convertible  Debentures  Due  June  30,  2007.  Notwithstanding
anything herein to the contrary, no Qualified  Indebtedness may be incurred (but
excluding  Acquisition  Indebtedness) unless as a condition to the incurrence of
such  Indebtedness,  the Company shall have made cash collateral  payments in an
aggregate  amount of  Outstanding  Principal  Amount of all Debentures as of the
date of the  incurrence  of such  Indebtedness  (pro rata  among all  holders of
Debentures) in accordance with Section  25(g)(ii)  hereof equal to fifty percent
(50%) of the principal  amount of the  Indebtedness  so incurred or an amount as
otherwise  required by this Section 25 (or if such amount  exceeds the remaining
Outstanding  Principal  Amount on all outstanding  Debentures  together with the
accrued  and unpaid  interest  thereon,  then an amount  equal to the  remaining
Outstanding  Principal  Amount on all outstanding  Debentures  together with the
accrued and unpaid  interest  thereon).  The Company  shall file with the SEC on
Form 8-K true and complete  copies of the  financial  statements  of an Acquired
Business  for which the  purchase  price is paid or payable in cash  and/or cash
equivalents  and/or  Indebtedness  indicating  thereon,  among other things, the
items  comprising  the EBITDA of the  Acquired  Business  and  contemporaneously
therewith,  but in no event prior to the filing of such Form 8-K, deliver a copy
of such financial  statements to each holder of Debentures;  provided,  however,
that,  notwithstanding  anything herein to the contrary, if the Company does not
file with the SEC financial  statements  of any Acquired  Business for which the
purchase  price  is paid or  payable  in cash  and/or  cash  equivalents  and/or
Indebtedness  in the time  and  manner  provided  herein,  then the  Acquisition
Multiple with respect to such Acquired Business shall be deemed zero (0) and the
Company  shall not be entitled to acquire  such  Acquired  Business  unless as a
condition thereto, the Company shall have  contemporaneously with the closing of
the acquisition of such Acquired Business made a cash collateral  payment on the
Outstanding  Principal Amount of the Debentures then outstanding (pro rata among
all holders of  Debentures)  in an amount equal to 100% of the  aggregate  cash,
cash  equivalents and Acquisition  Indebtedness  incurred in connection with the
acquisition  of such  Acquired  Business in  accordance  with Section  25(g)(ii)
hereunder (or if such amount exceeds the remaining  Outstanding Principal Amount
on all  outstanding  Debentures  together  with the accrued and unpaid  interest
thereon,  then an amount equal to the remaining  Outstanding Principal Amount on
all  outstanding  Debentures  together  with the  accrued  and  unpaid  interest
thereon).

(ii)  Notwithstanding  the  foregoing,  so  long  as any of the  Debentures  are
outstanding and cash  collateral  payments have not been made in an amount equal
to the entire  Outstanding  Principal  Amount and accrued and unpaid interest on
all  Debentures  pursuant  to  Section  25(g),  no Pari  Passu  Indebtedness  or
Subordinated  Indebtedness  may be  incurred,  directly  or  indirectly,  by the
Company or any of its Subsidiaries if during the period  commencing on the tenth
(10th)  Business  Day (or in the case of clause (ii) of the  definition  of Pari
Passu Indebtedness, the twentieth (20th) Business Day) immediately preceding the
incurrence of any such Pari Passu Indebtedness or Subordinated  Indebtedness and
ending on and  including the date on which any such Pari Passu  Indebtedness  or
Subordinated  Indebtedness  is incurred  (A) an event  constituting  an Event of
Default or an event that with the passage of time and without  being cured would
constitute  an  Event  of  Default,  has  occurred  and is  continuing,  (B) any
Registration  Statement  that  is  required  to be  effective  pursuant  to  the
Registration  Rights Agreement is not effective and available for the sale of at
least all of the Registrable  Securities (as defined in the Registration  Rights
Agreement)  required to be included in such Registration  Statement  pursuant to
the terms of the  Registration  Rights Agreement or (C) there has been any Grace
Period (as such term is defined in the Registration Rights Agreement).

(iii)  If at any  time  when  any of the  Debentures  are  outstanding  and cash
collateral  payments  shall not have been made in an amount  equal to the entire
Outstanding  Principal Amount of the Debentures,  together with accrued interest
thereon,  in accordance with Section  25(g)(ii),  the Company shall purchase any
Acquired Business, whether in one or a series of transactions,  for an amount of
aggregate  consideration (whenever paid in the form of cash, cash equivalents or
Acquisition  Indebtedness)  that  exceeds  the  Acquisition  Multiple  for  such
Acquired  Business,   (such  excess  amount,  the  "Excess  Permitted  Aggregate
Consideration"),  the  Company  shall,  simultaneous  with  the  closing  of the
purchase of the Acquired Business,  make cash collateral  payments in respect of
an aggregate  Outstanding Principal Amount of the Debentures (pro rata among all
holders of Debentures) in accordance with Section  25(g)(ii) hereof equal to one
hundred percent (100%) of the Excess Permitted  Aggregate  Consideration  (or if
such  amount  exceeds  the  remaining   Outstanding   Principal  Amount  on  all
outstanding  Debentures  together with the accrued and unpaid interest  thereon,
then an  amount  equal to the  remaining  Outstanding  Principal  Amount  on all
outstanding Debentures together with the accrued and unpaid interest thereon).

(c) Restricted  Payments.  Notwithstanding  anything herein to the contrary,  so
long as any of the Debentures are outstanding and cash collateral  payments have
not been made in an amount equal to the entire Outstanding  Principal Amount and
accrued and unpaid  interest on all Debentures  pursuant to Section  25(g),  the
Company shall not, and the Company shall not permit any of its  Subsidiaries to,
directly or indirectly redeem, defease,  repurchase,  repay or make any payments
in respect  of, by the  payment  of cash or  marketable  securities,  including,
without  limitation,  Common Stock (in whole or in part,  whether by way of open
market purchases,  tender offers, private transactions or otherwise), all or any
portion of any Pari Passu Indebtedness,  Qualified Mortgage Financing, Qualified
Inventory  Financing or  Subordinated  Indebtedness of the Company or any of its
Subsidiaries,  whether by way of payment in respect of principal of (or premium,
if any) or  interest  on,  such  Pari  Passu  Indebtedness,  Qualified  Mortgage
Financing,   Qualified  Inventory  Financing  or  Subordinated  Indebtedness  or
otherwise;  provided,  however, that, so long as no event constituting,  or that
with the passage of time and without being cured would  constitute,  an Event of
Default  has  occurred  and is  continuing,  on the  date  any of the  following
payments is due or is otherwise  made and subject to the terms and conditions of
any subordination  agreement entered into in connection with the issuance of any
Subordinated Indebtedness as provided herein, the Company may, without regard to
the foregoing  limitation:  (i) pay in cash scheduled interest payments, in each
case in the manner set forth in the original  documentation  governing such Pari
Passu Indebtedness,  Qualified Mortgage Financing, Qualified Inventory Financing
or Subordinated Indebtedness, at an annual rate not to exceed (A) 10% per annum,
if such interest rate is fixed,  or (B) the prime rate plus two percent (2%), if
such  interest  rate is  floating,  of such Pari Passu  Indebtedness,  Qualified
Mortgage Financing,  Qualified Inventory Financing or Subordinated Indebtedness,
and (ii) make any principal  payments when due on any Qualified  Indebtedness at
any time  prior to the  two-year  anniversary  of the  Original  Issuance  Date;
provided,  however,  that the Company may not make any such  principal  payments
unless as a condition to each time any such Qualified  Indebtedness is incurred,
other  than  Acquisition  Indebtedness,   (including  each  time  any  Qualified
Indebtedness is incurred under a revolving  credit  facility or otherwise),  the
Company  shall have made cash  collateral  payments  in an  aggregate  amount of
Outstanding Principal Amount of all Debentures then outstanding at the time such
Qualified  Indebtedness  was incurred (pro rata among all holders of Debentures)
in accordance with Section  25(g)(ii) hereof equal to fifty percent (50%) of the
principal amount of the Qualified  Indebtedness so incurred, it being understood
and agreed that,  for the  avoidance of doubt,  if the Company has not satisfied
its cash collateral  payment  obligations  under Section 25(g)(ii) in connection
with the incurrence of any such Qualified Indebtedness, the Company may not make
any of the principal payments otherwise permitted under this subsection (ii).

(d)  Restrictions on Liens. So long as any of the Debentures are outstanding and
cash  collateral  payments  have not been made in an amount  equal to the entire
Outstanding  Principal  Amount and accrued and unpaid interest on all Debentures
pursuant to Section 25(g), the Company shall not create, incur, assume or suffer
to exist, or permit any of its Subsidiaries to create,  incur,  assume or suffer
to exist,  any Lien upon or with  respect  to any of its  assets or  properties,
whether  now owned or  hereafter  acquired;  file or  suffer to exist  under the
Uniform  Commercial  Code or any similar law or statute of any  jurisdiction,  a
financing  statement  (or the  equivalent  thereof)  that names it or any of its
Subsidiaries  as  debtor;  sign  or  suffer  to  exist  any  security  agreement
authorizing  any secured party  thereunder to file such financing  statement (or
the  equivalent  thereof);  sell any of its  property  or assets  subject  to an
understanding or agreement, contingent or otherwise, to repurchase such property
or assets (including sales of accounts receivable) with recourse to it or any of
its  Subsidiaries  or  assign  or  otherwise  transfer,  or  permit  any  of its
Subsidiaries  to assign or  otherwise  transfer,  any  account or other right to
receive income; other than, as to all of the above, Permitted Liens;

     (e) Restricted Investments.


(i) Except as provided in Section 4(v) of the Securities  Purchase Agreement and
except for cash held by the Company's Belgian  Subsidiary in connection with the
Belgian Contribution,  so long as any of the Debentures are outstanding and cash
collateral  payments  have  not  been  made in an  amount  equal  to the  entire
Outstanding  Principal  Amount and accrued and unpaid interest on all Debentures
pursuant to Section 25(g), the Company shall not and shall not permit any of its
Subsidiaries to, directly or indirectly,  deposit or hold any cash,  securities,
certificates  of deposit,  investments or other funds or cash  equivalent in any
account for which the Agent has not executed an account  control  agreement  and
obtained a perfected first priority security interest thereover.

(ii)  So long as any of the  Debentures  are  outstanding  and  cash  collateral
payments  have not  been  made in an  amount  equal  to the  entire  Outstanding
Principal  Amount and accrued and unpaid interest on all Debentures  pursuant to
Section 25(g), the Company shall not, directly or indirectly,  make or commit or
agree to make any loan,  advance,  guarantee of obligations,  other extension of
credit or capital  contributions  to, or hold or invest in or commit or agree to
hold or invest  in,  or  purchase  or  otherwise  acquire  or commit or agree to
purchase or otherwise  acquire any shares of the capital  stock,  bonds,  notes,
debentures or other  securities of, or make or commit or agree to make any other
investment in, any other Person (including,  without limitation,  a Subsidiary),
or purchase  or own any futures  contract  or  otherwise  become  liable for the
purchase or sale of currency or other commodities at a future date in the nature
of a futures contract,  or otherwise transfer any cash, property or other assets
to any Subsidiary, or permit any of its Subsidiaries to do any of the foregoing,
other  than  in  connection  with  (i)  the  Interferon  Acquisition,   (ii)  an
acquisition  of, or  investment  in, the  assets or  capital  stock of any other
Person by the Company or any of its  Subsidiaries for  consideration  consisting
solely of  shares  of  Common  Stock  that are not  subject  to any  repurchase,
retirement or redemption obligation of the Company or any of its Subsidiaries (a
"Stock  Acquisition")  and (iii) the  contribution by the Company to its Belgian
Subsidiary of not more than $25,000 in the aggregate for the payment of ordinary
course business expenses (the "Belgian Contribution").

(f) Restrictions on Asset Sales and Purchases.  So long as any of the Debentures
are  outstanding  and cash  collateral  payments have not been made in an amount
equal to the entire Outstanding Principal Amount and accrued and unpaid interest
on all Debentures pursuant to Section 25(g), the Company shall not and shall not
permit any of its Subsidiaries to convey,  sell, lease or sublease,  transfer or
otherwise  dispose  of,  whether  in one  transaction  or a  series  of  related
transactions,  all or any part of its business,  property or assets, whether now
owned or hereafter  acquired (or agree to do any of the foregoing),  other than,
so long as no event  constituting  an Event of Default or an event that with the
passage of time and without  being cured would  constitute  an Event of Default,
has  occurred  and is  continuing  at the  time  of  such  sale,  (i)  sales  of
Intellectual  Property,  (ii)  sales of  Inventory  in the  ordinary  course  of
business (iii) or as otherwise expressly permitted under this Debenture. So long
as any of the Debentures are outstanding  and cash collateral  payments have not
been made in an amount  equal to the  entire  Outstanding  Principal  Amount and
accrued and unpaid  interest on all Debentures  pursuant to Section  25(g),  the
Company  shall not and shall not permit any of its  Subsidiaries  to purchase or
otherwise   acquire,   whether  in  one  transaction  or  a  series  of  related
transactions,  all or  substantially  all of the  assets of any  Person  (or any
division thereof), other than in connection with (A) the Interferon Acquisition,
(B)  the  incurrence  of  Acquisition   Indebtedness  to  the  extent  permitted
hereunder,  (C)  a  Qualified  Inventory  Financing,  (D) a  Qualified  Mortgage
Financing or (E) a Stock Acquisition.

     (g) Cash Collateral.

(i) Unless and until such time as the  Company  shall have made cash  collateral
payments  in  respect  of  the  entire  Outstanding  Principal  Amount  of  this
Debenture,  together with accrued and unpaid interest thereon, the Company shall
make cash  collateral  payments in accordance with this Section 25(g) in respect
of a portion of the Outstanding  Principal  Amount of this  Debenture,  together
with  accrued  and unpaid  interest  thereon,  in cash and/or  Common  Stock (as
provided in Section 25(g)(ii) and (iii)) as follows:

(A) on each Biweekly  Revenue Cash Collateral  Date, the Company shall make cash
collateral  payments  in  respect  of the  Outstanding  Principal  Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
product derived by multiplying (i) .5 by (ii) the Company Consolidated  Revenues
for the period  commencing  on the date of the  immediately  preceding  Biweekly
Revenue Cash Collateral Date (or the Original  Issuance Date, in the case of the
first  Biweekly   Revenue  Cash  Collateral   Date)  through  the  Business  Day
immediately preceding the applicable Biweekly Revenue Cash Collateral Date;

(B) on each Monthly  Revenue Cash  Collateral  Date, the Company shall make cash
collateral  payments  in  respect  of the  Outstanding  Principal  Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
greater of (i) the product  derived by multiplying  (a) .1 by (b) the portion of
the  Outstanding  Principal  Amount of all  Debentures  and  accrued  and unpaid
interest  thereon for which cash  collateral  payments  have not been made under
Section 25(g) as of March 31, 2004 and (ii) the product  derived by  multiplying
(a) .5 by (b) the Company Consolidated Revenues for the period commencing on the
date of the immediately preceding Monthly Revenue Cash Collateral Date (or April
1, 2004, in the case of the first Monthly Revenue Cash Collateral  Date) through
the Business Day  immediately  preceding  the  applicable  Monthly  Revenue Cash
Collateral Date;

(C) on the First Revenue  Milestone Cash Collateral Date, the Company shall make
cash collateral  payments in respect of the Outstanding  Principal Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
sum of (i) $400,000 and (ii) the product  derived by  multiplying  (X) .8 by (Y)
the amount, if any, by which the Company Consolidated  Revenues during the First
Revenue Milestone Measuring Period exceeds the First Revenue Milestone Target;

(D) on the Second Revenue Milestone Cash Collateral Date, the Company shall make
cash collateral  payments in respect of the Outstanding  Principal Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
excess,  if any, of (i) the sum of (a) $750,000  and (b) the product  derived by
multiplying (X) .8 by (Y) the amount, if any, by which the Company  Consolidated
Revenues during the Second Revenue Milestone Measuring Period exceeds the Second
Revenue  Milestone  Target,  over (ii) the cumulative  amount of cash collateral
payments (including the dollar value attributed to any such payments made in the
form  of  Repayment   Shares  in  accordance  with  the  provisions  of  Section
25(g)(iii))  that have  been made by the  Company  prior to the  Second  Revenue
Milestone Cash Collateral Date pursuant to Sections  25(g)(i)(A) and 25(g)(i)(C)
hereof;

(E) on the Third Revenue  Milestone Cash Collateral Date, the Company shall make
cash collateral  payments in respect of the Outstanding  Principal Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
excess,  if any, of (i) the sum of (a) $1,500,000 and (b) the product derived by
multiplying (X) .8 by (Y) the amount, if any, by which the Company  Consolidated
Revenues during the Third Revenue  Milestone  Measuring Period exceeds the Third
Revenue  Milestone  Target,  over (ii) the cumulative  amount of cash collateral
payments (including the dollar value attributed to any such payments made in the
form  of  Repayment   Shares  in  accordance  with  the  provisions  of  Section
25(g)(iii))  that  have  been made by the  Company  prior to the  Third  Revenue
Milestone Cash Collateral Date pursuant to Sections 25(g)(i)(A), 25(g)(i)(C) and
25(g)(i)(D) hereof;

(F) on the Qualified  Inventory  Financing Date,  subject to Section 28(d),  the
Company  shall make cash  collateral  payments  in  respect  of the  Outstanding
Principal Amount of all Debentures,  together with accrued interest thereon,  in
an amount an amount equal to $2,000,000.00; and

(G) on the Qualified  Mortgage  Financing  Date,  subject to Section 28(c),  the
Company  shall make cash  collateral  payments  in  respect  of the  Outstanding
Principal Amount of all Debentures,  together with accrued interest thereon,  in
an amount equal to $1,500,000.00.

(ii) On each Cash  Collateral  Date  (and any date for  which a cash  collateral
payment is  required  under this  Section  25),  the Company  shall  irrevocably
deposit, or cause to be irrevocably  deposited into the Cash Collateral Account,
the portion of the total  Outstanding  Principal  Amount of all  Debentures  and
accrued and unpaid  interest  thereon  for which cash  collateral  payments  are
required to be made in accordance with Section  25(g)(i) (or any other provision
of  Section  25  requiring  cash  collateral   payments),   subject  to  Section
25(g)(iii),  in cash in U.S.  Dollars  to secure  payment of the  principal  of,
premium,  if  any,  penalties,  if  any,  and  interest  due on the  outstanding
Debentures,  pursuant to the Account  Control  Agreement  and such other written
agreements  and other  arrangements  satisfactory  to the  holders of 60% of the
Outstanding  Principal Amount of all Debentures  issued on the Original Issuance
Date then outstanding,  which shall, among other things,  confirm that the funds
deposited  in the Cash  Collateral  Account  and the  proceeds  of any letter of
credit issued shall be subject to a perfected first priority  security  interest
in favor of the Agent for the benefit of the holders of Debentures.

(iii)  Notwithstanding  anything  in Section  25(g)(ii)  hereof,  but subject to
Sections 11 and 26 hereof,  (A) on each Cash  Collateral Date relating to a cash
collateral payment under Section  25(g)(i)(A),  the Company shall make a payment
by way of delivery of 25,000 fully paid and nonassessable shares of Common Stock
(as  equitably  adjusted for any stock  dividend,  stock split or other  similar
transaction  and pro rata among all holders of Debentures)  and (B) on each Cash
Collateral Date relating to a cash collateral payment under Section 25(g)(i)(B),
the Company  shall make a payment by way of  delivery  of 50,000  fully paid and
nonassessable  shares  of  Common  Stock (as  equitably  adjusted  for any stock
dividend,  stock  split or other  similar  transaction  and pro rata  among  all
holders of Debentures), in each case delivered to the holder in lieu of cash for
such amount (it being  understood  and agreed that (x) the remaining  balance of
such  payments,  if any,  shall  be paid in  cash  in  accordance  with  Section
25(g)(ii)  above and (y)  irrespective  of  whether  the value of the  shares of
Common Stock payable under clauses (A) or (B) of this Section 25(g)(iii) exceeds
the amount otherwise due under Section  25(g)(i)(A) or Section  25(g)(i)(B),  as
applicable,  the  Company  shall  issue the full  amount of the 25,000 or 50,000
shares of Common Stock,  as applicable,  on the applicable  Cash Collateral Date
and the value of the additional shares of Common Stock, if any, delivered to the
holder  that  exceed  the  amount  required  to be  paid  under  the  applicable
subsection of this Section 25(g) shall be deemed to be a permitted prepayment of
this  Debenture as provided in the final  sentence of this  Section  25(g)(iii))
represented  by duly executed stock  certificates  registered in the name of the
holder or its designee  (the  "Repayment  Shares")  (or, in the case of a public
resale  of such  Repayment  Shares  in  accordance  with the  provisions  of the
Irrevocable  Transfer  Agent  Instructions,   provided  the  Transfer  Agent  is
participating  in The DTC Fast  Automated  Securities  Transfer  Program and, if
required by DTC, the holder provides a customary  representation  letter to DTC,
upon the request of the holder, credit such aggregate number of shares of Common
Stock to which the holder shall be entitled to the holder's  designee's  balance
account with DTC through its Deposit  Withdrawal Agent  Commission  system) with
each  Repayment  Share  being  ascribed a valued for  purposes  of this  Section
25(g)(iii)  equal to the  product  derived  by  multiplying  (A) .825 by (B) the
arithmetic  average of Weighted  Average  Prices of the Common Stock on the five
consecutive  Business Days ending on and including the Business Day  immediately
preceding the applicable Cash Collateral Date (the "Equity Collateral Conversion
Rate") provided,  however,  that (x) in no event may the Company pay any portion
of a cash collateral  payment  obligation in Repayment  Shares if a Registration
Statement  is not then  effective  and  available  for the  resale of all of the
Repayment  Shares on the applicable  Cash  Collateral Date or each date which is
within 10 Business  Days prior to such Cash  Collateral  Date, in which case the
full amount of such payments  shall  instead be made in cash in accordance  with
Section  25(g)(ii)  and (y) in the event the Company  does not have a sufficient
number of Repayment Shares reserved and available for issuance  pursuant to this
Section  25(g)(iii),  the Company  shall issue the maximum  number of  Repayment
Shares  that  are  available  for  issuance,  pro  rata  among  all  holders  of
Debentures,  and the balance of such  payment  shall  instead be made in cash in
accordance with Section 25(g)(ii) hereof.  Cash collateral payments validly made
in the form of Repayment  Shares under this Section  25(g)(iii)  shall be deemed
prepayments  of (i)  first,  accrued  and  unpaid  interest  on the  Outstanding
Principal Amount of this Debenture and (ii) second, Outstanding Principal Amount
of this Debenture.

(iv) The  Company  covenants  and agrees  that it shall  make all  calculations,
including,   without  limitation,   all  calculations  of  Company  Consolidated
Revenues,  necessary to determine the amounts to be paid from time to time under
this Section 25(g) in strict  accordance with the terms of this  Agreement.  The
Company  further  covenants  and agrees  that it shall  prepare  and publish its
quarterly and annual  earnings  releases and quarterly and annual  reports filed
with the SEC with  sufficient  detail so that the holder of this Debenture shall
be able to determine and verify solely from the  information  contained  therein
the amount of Company Consolidated Revenues used to calculate amounts to be paid
from time to time  under  this  Section  25(g) and to  reconcile  the  amount of
Company Consolidated  Revenues with the amounts actually paid under this Section
25(g).  If any  holder  of  Debentures  disputes  any  calculations  of  Company
Consolidated  Revenues  set forth in or omitted  from any public  release or SEC
filing that covers any period  relevant for the  determinations  required  under
this Section  25(g),  such holder shall  deliver  written  notice to the Company
within ten  Business  Days of the  publication  of such  release or SEC  filing,
describing  in  reasonable  detail the basis for such  dispute  (and the Company
shall promptly deliver such notice to all other holders). If the Company and the
disputing  holder(s) of Debentures are unable to resolve any such dispute within
two Business Days of the Company's receipt of notice thereof,  the Company shall
within two (2)  Business  Days  submit  the  disputed  matters to the  Company's
independent,  outside  accountant.  The Company  shall cause the  accountant  to
perform  the  determinations  or  calculations  and notify the  Company  and the
holders of the  results no later  than ten (10)  Business  Days from the time it
receives  the  disputed   determinations  or  calculations.   Such  accountant's
determination,  as the case may be,  shall be binding  upon all  parties  absent
manifest  error.  The  Company  shall bear all costs,  fees and  expenses of the
accountant in rendering any such determinations.

(v) On each Cash  Collateral  Date, the Company  covenants and agrees to execute
and deliver a  completed  Cash  Collateral  Accounting  Certificate  in the form
attached hereto as Exhibit C (the "Cash  Collateral  Certificate")  by facsimile
and first  class mail to the Person  designated  on the form of Cash  Collateral
Certificate (or such other Person or Persons as the holders of not less than 60%
of the then Outstanding  Principal Amount of Debentures may designate in writing
to the  Company),  which shall be certified to each holder of Debentures as true
and correct by the Chief  Executive  Officer or Chief  Financial  Officer of the
Company.  THE COMPANY  ACKNOWLEDGES  AND AGREES THAT IN NO EVENT SHALL IT OR ANY
PERSON ON THE COMPANY'S  BEHALF DELIVER ANY CASH  COLLATERAL  CERTIFICATE TO ANY
HOLDER OF DEBENTURES WITHOUT THE EXPRESS PRIOR WRITTEN CONSENT OF SUCH HOLDER.

(vi) All payments by the Company pursuant to this Section 25(g),  whether in the
form of cash or Repayment Shares, shall be made pro rata among all Debentures.

(vii) Notwithstanding  anything herein to the contrary, the Company shall not be
obligated  to make any  collateral  payments,  or  deliver  any Cash  Collateral
Certificates,  pursuant to this Section  25(g)  (whether in cash or in shares of
Common Stock) on any Biweekly Revenue Cash Collateral Date, Monthly Revenue Cash
Collateral  Date, the First Revenue  Milestone Cash Collateral  Date, the Second
Revenue  Milestone  Cash  Collateral  Date, or the Third Revenue  Milestone Cash
Collateral  Date to the extent that the balance in the Cash  Collateral  Account
(as defined in the Securities Purchase Agreement) is not less than $1,300,000.

(viii) the Holder  agrees that, in the event of any  unauthorized  distributions
(as defined below) from the Cash Collateral  Account,  the principal  amounts of
the Debentures will be reduced by the amount of such unauthorized distributions;
the  allocation  of such  reduction to the PL Debentures to be made pro rata. An
unauthorized  distribution  would be any  distribution  other than as  permitted
under the PL Debentures or the related agreements.



(h)  Conflicts.  In the event there is any  conflict  among  provisions  of this
Section 25 as to the amount of any cash collateral  payment  required to be paid
by the Company into the Cash  Collateral  Account,  the provision  requiring the
Company to pay the greater amount shall in all instances control.

26.  Limitation  on Number of  Conversion  Shares.  The Company (1) shall not be
obligated to issue  Conversion  Shares upon  conversion of this  Debenture,  (2)
shall not be permitted  to issue  Interest  Shares (but instead  shall make Cash
Interest  Payments),  (3) shall not be permitted to issue Repayment  Shares (but
instead shall make cash collateral payments in cash), (4) shall not be permitted
to make a Company Conversion, and (5) shall not be permitted to issue conversion
shares, interest shares,  repayment shares, or warrant shares in connection with
the  Previously-Issued   Securities  (as  defined  in  the  Securities  Purchase
Agreement),  in each case to the  extent  that the  issuance  of such  shares of
Common  Stock  would cause the Company to exceed that number of shares of Common
Stock  which the Company may issue under this  Debenture  (the  "Exchange  Cap")
without  breaching the Company's  obligations  under the rules or regulations of
the Principal  Market,  except that such limitation shall not apply in the event
that the Company  obtains the  approval of its  stockholders  as required by the
Principal  Market (or any successor rule or regulation)  for issuances of Common
Stock in excess of such amount.  Until such approval is obtained,  the holder of
this  Debenture  shall not be issued,  upon  conversion or redemption  of, or as
interest under, this Debenture, shares of Common Stock in an amount greater than
the difference between (i) the product of (x) the Exchange Cap amount multiplied
by (y) a fraction,  the numerator of which is the aggregate  principal amount of
Debentures issued to such Holder pursuant to the Securities  Purchase  Agreement
and the  denominator  of  which is the  aggregate  principal  amount  of all the
Debentures issued to all Debenture  holders pursuant to the Securities  Purchase
Agreement  and (ii) the sum of (A) the aggregate  number of Interest  Shares and
Repayment  Shares  and shares  issued in  connection  with a Company  Conversion
issued to the holder of this Debenture (and all  predecessor  holders) as of the
date of such conversion plus (B) the aggregate  number of shares of Common Stock
issued to the holder of this  Debenture (and all  predecessor  holders) upon the
exercise of any Warrants held by such holder (and all predecessor holders) as of
the date of such  conversion  plus (C) the aggregate  number of shares of Common
Stock  issued to the  holder of this  Debenture  (and all  predecessor  holders)
pursuant  to  the  Previously-Issued   Securities  (such  difference,  the  "Cap
Allocation  Amount").  If at any time when the Holder shall deliver a Conversion
Notice pursuant to Section 4 hereof the Company shall be prohibited  pursuant to
the  provisions  of this  Section  26 from  issuing  all or any  portion  of the
Conversion Shares issuable pursuant to such Conversion Notice,  then the Company
shall pay in immediately  available funds to the holder of this Debenture within
two (2)  Business  Days of the date of delivery of such  Conversion  Notice,  an
amount in cash equal to the product of (X) the number of shares of Common  Stock
which could not be issued by virtue of the limitations contained in this Section
26  multiplied  by (Y) the average of the Weighted  Average  Price of the Common
Stock on each of the five (5)  trading  days  ending  on the third  trading  day
immediately  preceding the date the date of delivery of such Conversion  Notice.
The Outstanding Principal Amount of this Debenture shall be reduced by an amount
equal to the Outstanding  Principal  Amount of this Debenture  designated in the
Conversion  Notice that could not be converted by virtue of the  limitations set
forth in this Section 26 and for which the Company has made payment  pursuant to
the immediately preceding sentence.

27. Taxes.


(a) The Company shall pay any and all documentary,  stamp, transfer (but only in
respect of the  registered  holder  thereof) and other similar taxes that may be
payable  with  respect to the  issuance  and  delivery of Common  Stock upon the
conversion  of  Debentures;  provided,  however,  that the Company  shall not be
required to pay any tax that may be payable in respect of any transfer  involved
in the issue or delivery of Common  Stock or other  securities  or property in a
name other than that of the registered  holder of this Debenture to be converted
and such holder shall pay such amount, if any, to cover any applicable  transfer
or similar tax.

(b) The Company  shall be  permitted to withhold  from any amounts  payable to a
Debenture  holder or a holder of Common  Stock any taxes  required  by law to be
withheld  from such  amount.  If the  Company  shall be  required to withhold or
deduct any tax,  levy or other  governmental  charge,  excluding  (A) net income
taxes,  franchise  taxes,  or taxes  imposed  on or  measured  by net income (or
overall  gross  receipts,  to the extent such tax is imposed in lieu of a tax on
net income by a  jurisdiction  that does not impose any tax based on or measured
by net  income)  on any  Debenture  holder  by the  jurisdiction  in which  such
Debenture holder is organized or any other  jurisdiction in which such Debenture
holder would be subject to tax without regard to the  transactions  contemplated
hereby  and (B)  U.S.  Federal  withholding  taxes  (unless  such  U.S.  Federal
withholding  taxes would not be imposed but for a change in or  amendment to the
Internal Revenue Code of 1986, as amended (the "Code"), the Treasury Regulations
or any  other  administrative  authority  thereunder  or any tax  treaty  or the
release or promulgation of any judicial decision relating thereto, in each case,
on or after the date such Debenture holder acquires a Debenture (each, a "Change
in Law")) (all such non-excluded  taxes,  levies or other governmental  charges,
"Taxes") from any payment of interest, or any accrual of original issue discount
(if  applicable),  for U.S.  Federal income tax purposes made hereunder or under
any Debenture to or for the benefit of any Debenture holder, then (A) the amount
payable  shall be  increased  by the amount  necessary  so that after making all
required deductions and withholdings (including deductions and withholdings with
respect to additional  amounts  payable under this Section 27(b)) such Debenture
holder shall  receive an amount equal to the amount it would have received if no
such deduction or withholding of Taxes had been required,  (B) the Company shall
make such deduction or withholding and (C) the Company shall pay the full amount
deducted to the appropriate governmental authority in accordance with applicable
law. If any Debenture holder is organized under the laws of a jurisdiction other
than the United  States,  any State thereof or the District of Columbia  (each a
"Non-U.S.  Debenture  Holder"),  it shall  deliver to the  Company two copies of
either  (A)  U.S.  Internal  Revenue  Service  Form  W-8BEN  (claiming  complete
exemption from U.S. Federal  withholding tax under an income tax treaty), or any
successor form; (B) U.S. Internal Revenue Service Form W-8ECI (claiming complete
exemption from U.S.  Federal  withholding  tax because the income is effectively
connected with a U.S. trade or business), or any successor form; (C) in the case
of a Non-U.S.  Debenture Holder claiming exemption from U.S. Federal withholding
tax under  Section  871(h) or 881(c) of the Code,  with  respect to  payments of
"portfolio  interest," U.S. Internal Revenue Service Form W-8BEN  (certifying as
to beneficial  ownership),  or any successor form, and a certificate in form and
substance  reasonably  acceptable to the Company representing that such Non-U.S.
Debenture  Holder is not a "bank" for purposes of Section 881(c) of the Code, is
not a 10-percent  shareholder (within the meaning of Section 871(h)(3)(B) of the
Code) of the Company and is not a "controlled  foreign  corporation"  related to
the Company (within the meaning of Section  864(d)(4) of the Code); or (D) other
applicable form, certificate or document prescribed by the U.S. Internal Revenue
Service  certifying  as to such Non-U.S.  Debenture  Holder's  entitlement  to a
complete  exemption from U.S.  Federal  withholding  tax, as applicable,  in all
cases such forms and other documents being properly  completed and duly executed
by such Non-U.S.  Debenture Holder claiming complete exemption from U.S. Federal
withholding  tax on payments of interest  (or of  original  issue  discount,  if
applicable)  for U.S.  Federal  income tax  purposes  by the  Company  under the
Debentures.  Each  Debenture  holder  and each  holder of common  stock  that is
organized  under the laws of a jurisdiction  other than the United  States,  any
State thereof or the District of Columbia (each a "Non-U.S. Equity Holder") also
shall deliver to the Company,  to the extent legally able to do so, with respect
to payments of dividends for U.S. Federal income tax purposes by the Company, if
applicable,  two copies of either (A) U.S.  Internal Revenue Service Form W-8BEN
(claiming a reduction of U.S. Federal withholding tax under an applicable income
tax treaty,  if any), or any successor form, (B) U.S.  Internal  Revenue Service
Form W-8ECI  (claiming  complete  exemption from U.S.  Federal  withholding  tax
because the income is effectively  connected with a U.S. trade or business),  or
any  successor  form,  or (C) other  applicable  form,  certificate  or document
prescribed by the U.S.  Internal Revenue Service  certifying as to such Non-U.S.
Equity  Holder's  entitlement  to an  exemption  from,  or a reduction  of, U.S.
Federal  withholding  tax on payments of dividends for U.S.  Federal  income tax
purposes  by the  Company,  as  applicable,  in all cases  such  forms and other
documents  being  properly  completed and duly executed by such Non-U.S.  Equity
Holder. In addition,  each Debenture holder and each holder of Common Stock that
is not otherwise exempt from "back-up  withholding" shall deliver to the Company
two properly  completed  and duly  executed  copies of either (A) U.S.  Internal
Revenue Service Form W-8BEN,  or any successor form, (B) U.S.  Internal  Revenue
Service Form W-8ECI,  or any successor form, (C) U.S.  Internal  Revenue Service
Form W-9, or any successor form, or (D) other  applicable  form,  certificate or
document prescribed by the U.S. Internal Revenue Service, as applicable, in each
case  indicating  that such  Debenture  holder or holder of Common  Stock is not
subject to "back-up withholding" for U.S. Federal income tax purposes. The forms
and other  documents  required to be delivered  pursuant to this  Section  27(b)
shall be delivered  (A) on or prior to the Original  Issuance  Date and (B) from
time to time  thereafter  if within ten (10)  Business  Days after  receipt of a
written request therefor by the Company. In addition,  each Debenture holder and
each  holder of Common  Stock shall  promptly  notify the Company at any time it
determines  that  it is no  longer  in a  position  to  provide  any  previously
delivered (or requested) form, document or certificate to the Company, including
as a result in whole or in part from a Change in Law;  provided,  however,  that
the failure to provide such notice shall not affect any Debenture holder's right
to any additional amounts hereunder.

(c) Notwithstanding anything to the contrary in Section 27(b) above, the Company
shall not be  required  to pay any  additional  amount to any  Debenture  holder
pursuant to the  preceding  paragraph  to the extent the Tax in respect of which
such  additional  amount would  otherwise be payable would not have been imposed
but for the  failure of such  Debenture  holder to comply  with its  obligations
under such  paragraph;  provided,  however,  that the  failure  to  provide  the
applicable form, document or certificate  pursuant to the preceding paragraph as
provided in the notice required by the preceding paragraph resulting in whole or
in part from a Change in Law shall not affect such  Debenture  holder's right to
any additional amounts hereunder.

28. Security.


(a) The Debentures  shall be secured to the extent and in the manner provided in
the Security Agreement.

(b) The Company  acknowledges and agrees that all amounts  deposited in the Cash
Collateral  Account (a) shall  constitute  Collateral for all obligations of the
Company  under  the  Debentures  (the  "Obligations").  At any time  during  the
continuance  of an Event of Default,  the Agent may require the Cash  Collateral
Account Bank to transfer all amounts held in the Cash Collateral  Account to the
Agent  for  application  to  the  Obligations  pursuant  to  the  terms  of  the
Debentures.

(c) In the event that the Company  desires to enter into the Qualified  Mortgage
Financing, the holder, by its acceptance of this Debenture,  agrees to cause the
Agent to enter into a written agreement,  reasonably  satisfactory to the Agent,
providing that, upon the  consummation of the Qualified  Mortgage  Financing and
the Company making the deposit into the Cash Collateral Account of not less than
$1,500,000 in cash in accordance with Sections  25(g)(i)(G)  and 25(g)(ii),  the
Agent shall release its Lien on the Acquisition  Buildings and shall execute and
deliver to the Company or to the provider of such  financing or the purchaser of
the  Acquisition  Buildings such release or  reconveyance  instruments  and such
other  documents  as shall be  reasonably  necessary  to release the Lien of the
Agent on the Acquisition  Buildings  pursuant to the Mortgages,  in each case at
the  sole  cost  and  expense  of  the  Company  and  without  any  warranty  or
representation by, or recourse to, the Agent or the holder of this Debenture.

(d) In the event that the Company desires to enter into the Qualified  Inventory
Financing, the holder, by its acceptance of this Debenture,  agrees to cause the
Agent to enter into a written agreement,  reasonably  satisfactory to the Agent,
providing that, upon the consummation of the Qualified  Inventory  Financing and
the deposit into the Cash Collateral Account of not less than $2,000,000 in cash
in accordance with Sections  25(g)(i)(F) and 25(g)(ii),  the Agent shall release
its Lien on the Inventory and shall execute and deliver to the Company or to the
provider of such financing such UCC3 Amendments (or  authorizations  to file the
same) and such other  documents as shall be reasonably  necessary to release the
Lien of the Agent on the Inventory pursuant to the Security  Agreement,  in each
case at the sole cost and expense of the  Company  and  without any  warranty or
representation by, or recourse to, the Agent or the holder of this Debenture.

(e) If at any time the Company  shall have  deposited  into the Cash  Collateral
Account an amount equal to the entire  Outstanding  Principal Amount and accrued
and unpaid interest on all Debentures  pursuant to Section 25(g), the holder, by
its  acceptance  of this  Debenture,  agrees to  release,  or cause the Agent to
release, its Lien on all Collateral, other than the Cash Collateral Account, and
shall  execute  and  deliver to the  Company  (or cause the Agent to execute and
deliver to the Company) such release or reconveyance  instruments and such other
documents  as  shall  be  reasonably  necessary  to  release  the  Liens  on the
Collateral  (other  than the Cash  Collateral  Account) in each case at the sole
cost and expense of the Company and without any warranty or  representation  by,
or recourse to, the Agent or the holder of this Debenture.






                  IN WITNESS WHEREOF,  the Company has caused this instrument to
be duly executed by an officer thereunto duly authorized.

Dated:  October 6, 2005
                                   HEMISPHERX BIOPHARMA, INC.

                                   By: s/
                                       -------------------------------
                                                           Name:
                                                           Title:
                                                     Print Address:
                                                     Telephone:
                                                     Facsimile:

ATTEST
- ------------------------------
Name:
Title:







                                                     EXHIBIT I

                                       (To be Executed by Registered Holder
                                          in order to Convert Debenture)

                                                 CONVERSION NOTICE
                                                        FOR
7% SENIOR SECURED CONVERTIBLE DEBENTURE DUE JUNE 30, 2007

                  The   undersigned,   as  Holder  of  the  7%  Senior   Secured
Convertible  Debenture  Due June 30, 2007 of  HEMISPHERX  BIOPHARMA,  INC.  (the
"Company"),  No.  _,  in the  outstanding  principal  amount  of  $_______  (the
"Debenture"),  hereby elects to convert  $_______ of the  outstanding  principal
amount of the Debenture (as well as accrued and unpaid  interest) into shares of
Common Stock,  par value $0.001 per share (the "Common  Stock"),  of the Company
according to the conditions of the Debenture, as of the date written below.

         Date of Conversion:
                            ---------------------------------------------------

         Principal Amount of Debentures to be converted:

         Accrued Interest to be converted:
          ------------------------------------------

         Installment Date to which the amount to be converted relates:

         Tax ID Number (If applicable):
           -------------------------------------------

Please confirm the following information:

         Conversion Price:_______________________

         Number of shares of Common Stock to be issued:

         Is the Variable Price being relied on pursuant to Section
                   6(c) of the Debenture?  (check one)  YES ____ No ____






         Please  issue the  Common  Stock into  which the  Debentures  are being
converted  and, if  applicable,  any check drawn on an account of the Company in
the following name and to the following address:

                  Issue to:
                           ------------------------------

2469:

                  Address: _________________________________________

                  Telephone Number: ________________________________

                  Facsimile Number:
                                   ----------------------------------

                  Authorization:
                                ------------------------------------

                  By:
                     -------------------------------------------

                  Title:
                        ----------------------------------------

                  Dated:
                  Account Number (if electronic book entry transfer):

                  Transaction Code Number (if electronic book entry transfer):



[NOTE TO HOLDER -- THIS FORM MUST BE SENT CONCURRENTLY TO TRANSFER AGENT]




                                                  ACKNOWLEDGMENT


                  The Company hereby  acknowledges  this  Conversion  Notice and
hereby  directs  Continental  Stock  Transfer & Trust Company to issue the above
indicated  number of shares of Common Stock in accordance  with the  Irrevocable
Transfer  Agent  Instructions  dated January 26, 2004 (as amended on October 24,
2005) from the  Company  and  acknowledged  and agreed to by  Continental  Stock
Transfer & Trust Company.


                                             HEMISPHERX BIOPHARMA, INC.


                                       By:
                                            ------------------------------
                                      Name:
                                            ------------------------------
                                     Title:
                                            ------------------------------










Account Control Agreement...................................................2
Acquiring Entity............................................................16
Act.........................................................................2
Agent.......................................................................3
Approved Stock Plan.........................................................3
ASE.........................................................................3
Bloomberg...................................................................3
Business Day................................................................3
Cap Allocation Amount.......................................................41
Cash Collateral Account.....................................................3
Cash Collateral Account Bank................................................3
Cash Collateral Certificate.................................................40
Cash Interest Payment.......................................................1
Cash Transaction..........................................................3,17
Change of Control...........................................................17
Change of Control Redemption Price..........................................16
Closing Sale Price.........................................................3,7
Collateral..................................................................4
Common Stock..............................................................4,46
Common Stock Deemed Outstanding.............................................4
Company...............................................................1,46, 55
Conversion Date.............................................................9
Conversion Failure..........................................................4
Conversion Notice...........................................................8
Conversion Price............................................................4
Conversion Rate.............................................................8
Convertible Securities......................................................4
Debenture.................................................................1,46
Debenture Delivery Date.....................................................9
Debenture Register..........................................................2
Debentures..................................................................1
Default Conversion Price....................................................4
Default Interest............................................................2
Dilutive Issuance...........................................................12
DTC.........................................................................9
Events of Default...........................................................19
Exchange Act................................................................25
Exchange Cap................................................................40
Fixed Conversion Price......................................................4
Holder......................................................................1
Indebtedness................................................................21
Intellectual Property.......................................................4
Interest Payment Date.......................................................1
Interest Payments...........................................................1
Interferon Acquisition......................................................4
Letters of Credit...........................................................5
Mandatory Conversion........................................................7
Mandatory Conversion Date...................................................8
Mandatory Conversion Measuring Period.......................................7
Mandatory Conversion Notice.................................................7
Maturity Date...............................................................1
Maturity Date Mandatory Redemption..........................................11
Maturity Date Redemption Price..............................................11
Mortgage....................................................................5
NASDAQ......................................................................5
New Securities Issuance Price...............................................2
Notice of Change of Control.................................................16
Notice of Redemption Upon Change of Control..............................16,17
NYSE........................................................................5
Options.....................................................................5
Organic Change..............................................................15
Original Issuance Date......................................................5
Outstanding Principal Amount................................................5
Person......................................................................5
Principal Market............................................................5
Quarterly Period............................................................5
Registration Rights Agreement...............................................5
Rule 144....................................................................25
SEC.........................................................................5
Securities Agreement........................................................6
Securities Purchase Agreement...............................................6
Share Delivery Date.........................................................8
Strategic Financing.........................................................6
Transaction Documents.......................................................6
Transfer Agent..............................................................8
Valuation Event.............................................................14
Warrants....................................................................6
Weighted Average Price.....................................................6,7




                                                     EXHIBIT A



                                             Subordination Provisions

Section 1.  Definitions.  As used  herein,  the  following  terms shall have the
following meanings:

"Borrower" shall mean [Hemispherx][applicable Subsidiary of Hemispherx].

"Hemispherx" shall mean Hemispherx Biopharma, Inc., a corporation duly organized
and existing under the laws of the State of Delaware.

"Loan  Documents"  shall mean any  agreement  executed  in  connection  with the
issuance of the Senior Debt, in each case as amended,  supplemented or otherwise
modified from time to time.

"Obligations"  shall  mean the  obligations  of the  Borrower  now or  hereafter
existing in favor of the  holders of the Senior  Debt,  whether  for  principal,
interest  (including  interest accruing subsequent to the filing of any petition
initiating  any   bankruptcy,   insolvency,   arrangement,   reorganization   or
receivership proceedings relating to the Borrower), fees, expenses or otherwise.

"Senior Debt" shall mean the Borrower's 7% Senior Secured Convertible Debentures
due June 30, 2007.

"Subordinated Creditor" shall mean            .
                                ----------------

"Subordinated Debt" shall mean all indebtedness of the Borrower now or hereafter
existing in favor of the  Subordinated  Creditor,  whether  created  directly or
acquired by assignment or otherwise, all interest thereon and all fees, premiums
and other amounts payable in respect thereof.

"Subordinated Loan Documents" shall mean the instruments and agreements to which
the Borrower is a party evidencing or relating to any Subordinated Debt.

                  Section 2. Agreement to Subordinate.  Each of the Subordinated
Creditor,  Hemispherx and the Borrower agrees that the Subordinated  Debt is and
shall be subordinate,  to the extent and in the manner hereinafter set forth, in
right of payment to the prior payment in full of the Obligations.

                  Section 3. Restrictions on Payment of the Subordinated Debt.
                             -------------------------------------------------

                  (a) The  Subordinated  Creditor may receive,  and the Borrower
may pay,  interest on the Subordinated  Debt evidenced by the Subordinated  Loan
Documents,  in the stated amounts and on the stated dates of payment  thereof as
set forth in the Subordinated Loan Documents,  provided,  however,  that no such
payments  shall be received or made at any time during which an Event of Default
(as defined in the Senior  Debt) shall have  occurred and be  continuing  on any
Senior Debt.

                  (b) In the event of any dissolution,  winding up, liquidation,
arrangement  or  reorganization  relating to Hemispherx or the Borrower,  in any
bankruptcy, insolvency, arrangement,  reorganization or receivership proceedings
or upon an assignment  for the benefit of creditors or any other  marshalling of
the assets  and  liabilities  of  Hemispherx  or the  Borrower,  any  payment or
distribution  of any kind (whether in cash,  securities or other property) which
otherwise  would  be  payable  or  deliverable  upon  or  with  respect  to  the
Subordinated  Debt shall be paid or  delivered  directly  to the  holders of the
Senior Debt for  application  (in the case of cash) to, or as collateral (in the
case of securities or other non-cash property) for, the payment or prepayment of
the Obligations until the Obligations shall have been paid in full.

                  (c) All payments or distributions  upon or with respect to the
Subordinated  Debt which are received by the Subordinated  Creditor  contrary to
these subordination provisions shall be received in trust for the benefit of the
holders of the Senior Debt for the  ratable  benefit of such  holders,  shall be
segregated from other funds and property held by the  Subordinated  Creditor and
shall be  forthwith  paid over to the holders of the Senior Debt for the ratable
benefit of such  holders  in the same form as so  received  (with any  necessary
endorsement)  to be applied (in the case of cash) to or held as  collateral  (in
the case of securities or other non-cash property) for the payment or prepayment
of the Obligations until the Obligations shall have been paid in full.

                  Section 4.        Obligations Unconditional.
                                    -------------------------

                  (a) All rights and interests of the holders of the Senior Debt
hereunder,  and all agreements and  obligations  of the  Subordinated  Creditor,
Hemispherx  and the  Borrower  hereunder,  shall remain in full force and effect
irrespective of: (i) any lack of validity or enforceability of any Loan Document
or any other agreement or instrument  relating  thereto,  (ii) any change in the
time,  manner or place of payment of, or in any other term in respect of, all or
any of the  Obligations,  or any other  amendment or waiver of or any consent to
departure  from  any Loan  Document,  (iii)  any  exchange  or  release  of,  or
non-perfection  of any lien on or security  interest in, any collateral,  or any
release or amendment or waiver of or consent to departure from any guaranty, for
all or any of the  Obligations,  or (iv)  any  other  circumstance  which  might
otherwise  constitute a defense  available to, or a discharge of,  Hemispherx or
the  Borrower  in  respect  of the  Obligations  or the  Subordinated  Creditor,
Hemispherx or the Borrower in respect of these subordination provisions.

                  (b)  These  subordination  provisions  shall  continue  to  be
effective or shall be reinstated, as the case may be, if at any time any payment
of any of the  Obligations  is  rescinded  or must  otherwise be returned by the
holders of the Senior Debt upon the insolvency,  bankruptcy or reorganization of
Hemispherx or the Borrower or otherwise, all as though such payment had not been
made.

                  Section  5.  Waivers.  Each  of  the  Subordinated   Creditor,
Hemispherx and the Borrower waives (i) promptness and diligence,  (ii) notice of
acceptance  and notice of the  incurrence of any Obligation by Hemispherx or the
Borrower,  (iii) notice of any actions  taken by the holders of the Senior Debt,
Hemispherx  or the Borrower  under any Loan  Document or any other  agreement or
instrument relating thereto, (iv) all other notices,  demands and protests,  and
all other  formalities of every kind in connection  with the  enforcement of the
Obligations or of the obligations of the Subordinated  Creditor,  Hemispherx and
the Borrower under these subordination  provisions,  the omission of or delay in
which,  but for the provisions of this Section 5, might  constitute  grounds for
relieving  the  Subordinated  Creditor,   Hemispherx  or  the  Borrower  of  its
obligations  under these  subordination  provisions and (v) any requirement that
the holders of the Senior Debt protect,  secure,  perfect or insure any security
interest or other lien or any property  subject  thereto or exhaust any right to
take any action against Hemispherx or the Borrower or any other person.

                  Section 6.  Subrogation.  No payment  or  distribution  to the
holders of the Senior Debt  pursuant  to these  subordination  provisions  shall
entitle  the  Subordinated  Creditor to exercise  any rights of  subrogation  in
respect thereof until the Obligations shall have been satisfied in full.

                  Section 7.        Miscellaneous.
                                    -------------

                  (a)  Each of the  Subordinated  Creditor,  Hemispherx  and the
Borrower  will,  at its expense and at any time and from time to time,  promptly
execute and deliver all further  instruments and other  documents,  and take all
further  action that the holders of the Senior  Debt may  reasonably  request in
order to reflect the subordination provisions set forth herein.

                  (b) These  subordination  provisions  shall be governed by and
construed in accordance  with the law of the State of New York without regard to
principles  of conflicts  of law or choice of law (other than section  5-1401 of
the New York General  Obligations Law). The parties hereto hereby agree that all
actions or proceedings arising directly or indirectly from or in connection with
these  subordination  provisions shall be litigated only in the Supreme Court of
the State of New York or the  United  States  District  Court  for the  Southern
District of New York located in New York County,  New York.  The parties  hereto
consent to the  jurisdiction  and venue of the foregoing courts and consent that
any process or notice of motion or other application to either of said courts or
a judge  thereof  may be served  inside or outside  the State of New York or the
Southern  District of New York by registered  mail,  return  receipt  requested,
directed as provided in (and service so made shall be deemed  complete  five (5)
days after the same has been posted as aforesaid)  or by personal  service or in
such other  manner as may be  permissible  under the rules of said  courts.  The
parties  hereto  hereby waive any right to a jury trial in  connection  with any
litigation pursuant to these subordination provisions.







                                    EXHIBIT B

                                    Inventory







                                    EXHIBIT C

                       FORM OF CASH COLLATERAL CERTIFICATE

IN NO EVENT SHALL THIS  CERTIFICATE  BE DELIVERED BY OR ON BEHALF OF THE COMPANY
TO ANY HOLDER OF DEBENTURES  WITHOUT THE EXPRESS  PRIOR WRITTEN  CONSENT OF SUCH
HOLDER.

CERTIFICATE TO BE DELIVERED ONLY TO THE RECIPIENT DESIGNATED BELOW.

To:

Eleazer Klein, Esq.
Schulte Roth & Zabel LLP
919 Third Avenue
New York, NY  10022
Telephone:  (212) 756-2000
Facsimile:   (212) 593-5955

                  The   undersigned,   the   duly   elected   [Chief   Executive
Officer/Chief Financial Officer] of HEMISPHERX BIOPHARMA,  INC. (the "Company"),
hereby certifies to the holders of the 7% Senior Secured Convertible  Debentures
Due June 30, 2007 of the Company (the "Debentures") pursuant to Section 25(g)(v)
of the  Debentures,  that the following  information  is true and correct in all
respects  (capitalized  terms used in this  certificate  and not defined  herein
shall have the meanings ascribed to them in the Debentures):

         Cash Collateral Date:                        .
                              ------------------------

         Qualified Inventory Financing Date (if applicable):                .
                                                          ------------------
         Qualified Mortgage Financing Date (if applicable):                 .
                                                          ------------------
         Amount of Cash Collateral Payment: $                               .
                                             -------------------------------
         Amount of Cash Collateral Payment Made in Cash: $                  .
                                                          ------------------
         Aggregate Dollar Value of Cash Collateral  Payments Made
         in Repayment Shares (if     applicable): $             .
                                                    -------------
         Aggregate Number of Repayment Shares Issued (if applicable):       .
                                                                     --------
         Equity Collateral Conversion Rate (if applicable):                 .
                                                           ------------------
         Company Consolidated  Revenues for the relevant period (if applicable):
$                  .
- -------------------

         Aggregate Amount of Cash Collateral Payments Made Prior to this Cash
         Collateral Date:$              .
                          --------------


         IN WITNESS WHEREOF, the undersigned has executed this certificate as of
this         day of           , 200  .
   ----------     ------------     -

                                          ------------------------------