Exhibit 10.4

THE SECURITIES  REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY
NOT BE OFFERED FOR SALE, SOLD,  TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN
EFFECTIVE  REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF
1933,  AS AMENDED,  OR  APPLICABLE  STATE  SECURITIES  LAWS OR (B) AN OPINION OF
COUNSEL,  REASONABLY  SATISFACTORY  TO THE  COMPANY,  THAT  REGISTRATION  IS NOT
REQUIRED UNDER SAID ACT OR APPLICABLE  STATE SECURITIES LAWS. THE SECURITIES MAY
BE PLEDGED IN CONNECTION  WITH A BONA FIDE MARGIN  ACCOUNT OR OTHER LOAN SECURED
BY THE SECURITIES.

No.                                                              $
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                          HEMISPHERX BIOPHARMA, INC.

       SERIES C 7% SENIOR SECURED CONVERTIBLE DEBENTURE DUE JUNE 30, 2007

                 THIS DEBENTURE  (this  "Debenture") is one of a duly authorized
issue of  replacement  Debentures of HEMISPHERX  BIOPHARMA,  INC., a corporation
duly  organized  and  existing  under  the laws of the  State of  Delaware  (the
"Company"),  now designated as its 7% Senior Secured Convertible  Debentures Due
June 30, 2007.  The  Debenture is one of a series of  debentures  that amend and
replace a series of 6% Senior  Convertible  Debentures  due  January  31,  2006,
originally in an aggregate  principal  amount of up to Two Million U.S.  Dollars
(U.S. $2,000,000) (the "Debentures").  The Debenture and the Series A and Series
B 7% Senior Secured Convertible  Debentures Due June 30, 2007 are pari passu and
the designation of series is for identification purposes only.

FOR VALUE RECEIVED,  the Company promises to pay to , the holder hereof,  or its
registered  assigns (the "Holder"),the principal sum of Dollars($____) when due,
whether on June 30, 2007 (subject to extension as provided herein, the "Maturity
Date") or on any Installment Date with respect to the Installment  Amount due on
such Installment Date (each, as defined herein),  and to pay interest ("Interest
Payments") on the Outstanding Principal Amount at the rate of 7% per annum which
shall be cumulative,  accrue, but not compound,  daily from the date of issuance
of this  Debenture  and be due and  payable  in arrears on the first day of each
Quarterly Period commencing with the Quarterly Period immediately  following the
date of issuance of this Debenture  (each, an "Interest  Payment Date").  If the
Maturity  Date is not a Business  Day, then the Maturity Date shall be deemed to
be the Business Day immediately following such date. If an Interest Payment Date
is not a Business Day, then the Interest Payment shall be due and payable on the
Business Day immediately  following such Interest  Payment Date.  Subject to the
limitations in Sections 11 and 26,  interest shall be payable by the issuance of
shares of Common  Stock  ("Interest  Shares") to the Holder or, at the option of
the Company, in cash (the "Cash Interest Payment");  provided, however, that the
Company may not make Cash  Interest  Payments  and  interest  payments  shall be
payable in Interest  Shares unless the Company  provides  written notice to each
holder  of  Debentures  at least  five  Business  Days  prior to the  applicable
Interest  Payment  Date  that  such  Interest  Payments  shall  be made in cash.
Interest Shares shall be paid in a number of fully paid and nonassessable shares
(rounded up or down to the  nearest  whole  share) of Common  Stock equal to the
quotient  of (1)  the  amount  of the  Interest  Payment  due on the  applicable
Interest Payment Date divided by (2) ninety-five percent (95%) of the arithmetic
average of the Closing  Sale Price of the Common  Stock on the five  consecutive
Business  Days  ending on and  including  the  third  Business  Day  immediately
preceding the applicable  Interest  Payment Date (the "Interest Share Conversion
Rate");  provided,  further; that in no event may the Company issue more than an
aggregate of 40,000 shares of Common Stock (as equitably  adjusted for any stock
dividend, stock split or other similar transaction),  pro rata among all holders
of Debentures,  in respect of any single Interest  Payment (it being  understood
that the balance of each such  Interest  Payment  shall be paid in the form of a
Cash Interest  Payment).  Notwithstanding  the  foregoing,  the Company shall be
required to make a Cash Interest Payment on any Interest Payment Date if (a) any
event constituting an Event of Default or an event that with the passage of time
and without being cured would  constitute an Event of Default,  has occurred and
is  continuing  on the  Interest  Payment  Date or any date  which is  within 10
Business Days prior to the Interest Payment Date, unless otherwise  consented to
in writing by the holder of the  Debenture  entitled  to receive  such  Interest
Payment  or (b) from and  after  the time that any  Registration  Statement  (as
defined in the Registration Rights Agreement,  the "Registration  Statement") is
required to be effective,  such Registration Statement is not then effective and
available for the resale of all of the Registrable Securities (as defined in the
Registration  Rights  Agreement) on the Interest Payment Date or each date which
is within 10 Business Days prior to the Interest  Payment Date.  Any accrued and
unpaid  interest which is not paid within five (5) Business Days of the Interest
Payment Date on which such  payment of interest  was due shall bear  interest at
the rate of 14.0% per annum from such  Interest  Payment  Date until the same is
paid in full  (or,  if  less,  the  maximum  interest  rate  then  permitted  by
applicable law) (the "Default Interest").

Interest  Payments and payments of principal  will be paid only to the person in
whose name this Debenture (or one or more predecessor  Debentures) is registered
on the  records of the  Company  regarding  registration  and  transfers  of the
Debentures (the "Debenture Register").

This Debenture is subject to the following additional provisions:

1. Exchange.  The Debentures are exchangeable  for an equal aggregate  principal
amount of  Debentures  of  different  denominations,  as requested by the Holder
surrendering  the same. No service charge will be charged to the Holder for such
registration transfer or exchange.

2.   Transfers.   This   Debenture   has  been  issued   subject  to  investment
representations  of the  original  purchaser  hereof and may be  transferred  or
exchanged in the United States only in  compliance  with the  Securities  Act of
1933, as amended (the "Act"), and applicable state securities laws. Prior to due
presentment for transfer of this Debenture,  the Company may treat the person in
whose name this Debenture is duly registered on the Company's Debenture Register
as the owner hereof for the purpose of receiving  payment as herein provided and
all other  purposes,  whether or not this Debenture is overdue,  and the Company
shall not be affected by notice to the contrary.

3. Definitions. For purposes of this Debenture, the location of defined terms in
this  Debenture  is set  forth on the  Index of Terms  attached  hereto  and the
following terms shall have the following meanings:

"Account  Control  Agreement"  shall have the  meaning  ascribed  thereto in the
Securities Purchase Agreement.

"Agent"  shall mean  Portside  Growth &  Opportunity  Fund,  in its  capacity as
collateral  agent for the  holders  of  Debentures,  and any  successor  in such
capacity.

"Approved Stock Plan shall mean any employee  benefit plan, stock incentive plan
or other  similar plan or  arrangement  which has been  approved by the Board of
Directors of the Company or any authorized committee thereof,  pursuant to which
the Company's securities may be issued to any employee,  officer,  consultant or
director for services provided to the Company.

"ASE" shall mean The American Stock Exchange.
 ---

"Bloomberg"  shall  mean  Bloomberg  Financial  Markets  or  any  other  similar
financial  reporting service as may be selected from time to time by the Company
and the holders of not less than 60% of the then Outstanding Principal Amount of
Debentures issued on the Original Issuance Date.

"Business Day" shall mean any day other than  Saturday,  Sunday or any other day
on which  commercial banks in The City of New York are authorized or required by
law to remain closed.

"Cash  Collateral  Account" shall mean the account  maintained by the Company at
the Cash  Collateral  Account Bank, in the name of Portside Growth & Opportunity
Fund ("Portside") and subject to the control of Portside pursuant to the Account
Control  Agreement,  together with any successor account designated by Portside.
The Cash  Collateral  Account  referred to herein is the same account being used
for all debentures of the Company, including replacement debentures,  originally
issued to Portside and Leonardo L.P. (collectively "PL Debentures").

"Cash Collateral Account Bank" shall mean the financial  institution  designated
as the Cash Collateral Account Bank under the Account Control Agreement.

"Cash  Transaction" shall mean any Organic Change with a third party on an arm's
length  basis  pursuant to which the holders of the Common  Stock are to receive
consideration consisting solely of cash.

"Closing  Sale Price"  shall  mean,  for any  security as of any date,  the last
closing  trade price for such  security on the  Principal  Market as reported by
Bloomberg,  or if the Principal  Market  begins to operate on an extended  hours
basis, and does not designate the closing trade price, then the last trade price
at 4:00 p.m., New York City Time, as reported by Bloomberg,  or if the foregoing
do  not  apply,   the  last  closing   trade  price  of  such  security  in  the
over-the-counter  market on the  electronic  bulletin board for such security as
reported by  Bloomberg,  or, if no last closing trade price is reported for such
security by  Bloomberg,  the last closing ask price of such security as reported
by Bloomberg,  or, if no last closing ask price is reported for such security by
Bloomberg,  the average of the highest bid price and the lowest ask price of any
market  makers for such  security as  reported in the "pink  sheets" by the Pink
Sheets LLC. If the Closing Sale Price cannot be calculated  for such security on
such date on any of the foregoing bases, the Closing Sale Price of such security
on such  date  shall be the fair  market  value as  mutually  determined  by the
Company and the holders of no less than 60% of the Outstanding  Principal Amount
of the Debentures issued on the Original Issuance Date then outstanding.  If the
Company  and the  holders  of the  Debentures  are unable to agree upon the fair
market value of the Common Stock,  then such dispute shall be resolved  pursuant
to Section  4(e)(iii)  below.  All such  determinations  shall be  appropriately
adjusted for any stock dividend, stock split or other similar transaction during
such period.

"Collateral" shall mean all of the property and assets,  other than Intellectual
Property,  and all interests therein and proceeds thereof now owned or hereafter
acquired by the Company, any of its Subsidiaries and any other Person upon which
a Lien is granted or  purported to be granted by such Person as security for all
or any part of the obligations of the Company under the Debentures.

"Common Stock" shall mean the Common Stock,  par value $0.001 per share,  of the
Company.

"Common Stock Deemed  Outstanding"  shall mean, at any given time, the number of
shares of Common Stock  actually  outstanding  at such time,  plus the number of
shares of Common Stock deemed to be outstanding pursuant to Sections 6(a)(i) and
6(a)(ii) hereof regardless of whether the Options or Convertible  Securities are
actually  exercisable  at such time,  but  excluding  any shares of Common Stock
owned or held by or for the account of the Company or issuable  upon  conversion
of the Debentures or exercise of the Warrants.

"Conversion  Failure" shall mean that for any reason the Holder has not received
all of the shares of Common  Stock to which the Holder is entitled  prior to the
tenth  (10th)  Business  Day after the Share  Delivery  Date with  respect  to a
conversion of this Debenture.

"Conversion  Price"  shall mean (A) as of any  Conversion  Date or other date of
determination   (other  than  with  respect  to  an  Installment  Amount  on  an
Installment  Date  pursuant  to a Company  Conversion  (as defined in Section 24
(a)), the Fixed Conversion Price, and (B) with respect to any Installment Amount
on an Installment  Date pursuant to a Company  Conversion,  at the option of the
Holder,  either the Fixed Conversion  Price or the Company  Conversion Price (as
defined  in  Section  24(d)),  each in  effect as of such  date and  subject  to
adjustment as provided herein.

"Convertible Securities" shall mean any stock or securities (other than Options)
directly or indirectly  convertible  into or  exchangeable  or  exercisable  for
Common Stock.

"Default Conversion Price" shall mean the lower of (a) the Conversion Price then
in effect and (b) 95% of the  lowest  Closing  Sale  Price  during the three (3)
trading  days  ending on and  including  the  Conversion  Date or other  date of
determination.

"Fixed  Conversion  Price" shall mean as of any Conversion Date or other date of
determination   $2.08,   subject  to   adjustment  as  provided  in  Section  6,
Anti-dilution Adjustments to Conversion Price.

"Intellectual Property" means all trademarks,  trade names, trade dress, service
marks,  service mark  registrations,  service  names,  patents,  patent  rights,
copyrights,    inventions,    technology   licenses,   approvals,   governmental
authorizations, trade secrets and other intellectual property rights.

"Interferon  Acquisition"  shall  mean the  acquisition  of  certain  assets and
technology  of  Interferon  Sciences,  Inc.  ("Interferon")  pursuant  to  asset
purchase  agreements,  dated as of March  11,  2003,  between  the  Company  and
Interferon,  a true and complete copy of which has been delivered by the Company
to each initial holder of Debentures in accordance with the Securities  Purchase
Agreement.

"Letters of Credit" shall mean the irrevocable  standby letters of credit in the
aggregate  stated amount of $1,000,000  issued by banks  acceptable to the Agent
and  naming  the Agent as  beneficiary,  and any  letters  of  credit  issued in
substitution or replacement  thereof, in accordance with the Securities Purchase
Agreement.

"Mortgage" shall mean each mortgage,  deed of trust or deed to secure debt, made
by the Company in favor of the Agent and  recorded  against  each real  property
location  acquired by the Company  from  Interferon  pursuant to the  Interferon
Acquisition.

"NASDAQ" shall mean The Nasdaq National  Market,  The Nasdaq Small Cap Market or
the ASE.

"NYSE" shall mean The New York Stock Exchange, Inc.
 ----

"Options"  shall  mean any  rights,  warrants  or options  to  subscribe  for or
purchase Common Stock or Convertible Securities.

"Original  Issuance  Date" shall mean July 13, 2004, the first date on which any
Debentures have been issued pursuant to the Securities Purchase Agreement.

"Outstanding  Principal  Amount" shall mean the principal sum  outstanding  from
time to time under this Debenture.

"Person" shall mean an individual, a limited liability company, a partnership, a
joint venture,  a corporation,  a trust, an  unincorporated  organization  and a
government or any department or agency thereof.

"Principal  Market"  shall mean the ASE, or if the Common Stock is not traded on
the ASE, then the principal securities exchange or trading market for the Common
Stock.

"Quarterly  Period"  shall  mean  each  of the  following  periods:  the  period
beginning on and including  January 1 and ending on and including  March 31; the
period  beginning on and including  April 1 and ending on and including June 30,
the  period  beginning  on and  including  July 1 and  ending  on and  including
September 30; and the period beginning on and including  October 1 and ending on
and including December 31.

"Registration  Rights  Agreement"  shall mean that certain  registration  rights
agreement between the Company and the initial holders of the Debentures relating
to the filing of a registration  statement  covering the resale of the shares of
Common Stock  issuable  upon  conversion of the  Debentures  and exercise of the
Warrants, as such agreement may be amended from time to time as provided in such
agreement.

"SEC" shall mean the United States Securities and Exchange Commission.

"Securities  Purchase  Agreement"  shall mean that certain  securities  purchase
agreement between the Company and the initial holders of the Debentures, as such
agreement may be amended from time to time as provided in such agreement.

"Security Agreement" shall mean that certain third amended and restated security
agreement  made by the  Company  in favor of the  Agent for the  benefit  of all
holders of the Debentures, as such agreement may be amended from time to time as
provided in such agreement.

"Strategic  Financing"  shall mean the  issuance  of Common  Stock or Options in
connection  with any  acquisition  by the  Company,  by whatever  means,  of any
business,  assets  or  technologies,  or  to  any  strategic  investor,  vendor,
customer,  lease or similar arrangement,  the primary purpose of which is not to
raise equity  capital;  provided that the  aggregate  number of shares of Common
Stock which the Company may issue pursuant to this  definition  shall not exceed
(i)  25% of the  total  outstanding  equity  on the  Original  Issuance  Date in
connection  with  any one or more  related  issuances  to  strategic  investors,
vendors,  customers,  lessors  or  similar  parties  or  (ii)  40% of the  total
outstanding  equity  on the  Original  Issuance  Date  in  connection  with  all
issuances to strategic investors, vendors, customers, lessors or similar parties
(in each case,  subject to adjustment for stock splits,  stock dividends,  stock
combinations and similar transactions).

"Subsidiary"  shall  mean,  as to any Person,  any entity in which such  Person,
directly or indirectly, owns 30% or more of the capital stock or other equity or
similar  interests or owns capital stock or holds an equity or similar  interest
which  ownership  entitles  such  Person  to elect  30% or more of the  board of
directors or similar governing body of such entity.

"Transaction   Documents"  shall  have  the  meaning  ascribed  thereto  in  the
Securities Purchase Agreement.

"Warrants"  shall mean the warrants to purchase shares of Common Stock issued by
the Company pursuant to the Securities Purchase Agreement.

"Weighted Average Price" shall mean, for any security as of any date, the dollar
volume-weighted  average  price  per share for such  security  on the  Principal
Market during the period  beginning at 9:30 a.m., New York City Time, and ending
at 4:00 p.m.,  New York City Time, as reported by Bloomberg  through its "Volume
at  Price"   function  or,  if  the  foregoing   does  not  apply,   the  dollar
volume-weighted average price per share of such security in the over-the-counter
market on the  electronic  bulletin  board for such  security  during the period
beginning at 9:30 a.m.,  New York City Time,  and ending at 4:00 p.m.,  New York
City Time, as reported by Bloomberg,  or, if no dollar  volume-weighted  average
price is reported for such security by Bloomberg for such hours,  the average of
the  highest  closing  bid price and the lowest  closing ask price of any of the
market  makers for such  security as  reported in the "pink  sheets" by the Pink
Sheets LLC. If the Weighted Average Price cannot be calculated for such security
on such date on any of the foregoing  bases,  the Weighted Average Price of such
security on such date shall be the fair market value as mutually  determined  by
the  Company and the  holders of no less than 60% of the  Outstanding  Principal
Amount of the Debentures  issued on the Original Issuance Date then outstanding.
If the Company and the  holders of the  Debentures  are unable to agree upon the
fair  market  value of the Common  Stock,  then such  dispute  shall be resolved
pursuant to Section  4(e)(iii)  with the term  "Weighted  Average  Price"  being
substituted for the term "Closing Sale Price." All such determinations  shall be
appropriately  adjusted  for any stock  dividend,  stock split or other  similar
transaction during such period.


4.Conversion.  The  Holder  of this  Debenture  shall  have  the  following
conversion rights:


a) Holder's  Right to  Convert.  Subject to  Sections  11 and 26, at any time or
   times until 5:00 p.m.,  New York City Time,  on the Business Day prior to the
   Maturity  Date this  Debenture  is  convertible,  at the option of the Holder
   hereof,  into fully paid,  validly issued and nonassessable  shares of Common
   Stock in  accordance  with  Section 4(d) at the  Conversion  Rate (as defined
   below). The Holder hereof may convert a portion of the Outstanding  Principal
   Amount of this  Debenture if such portion is an integral  multiple of $1,000.
   If this  Debenture  remains  outstanding  on the  Maturity  Date,  then  this
   Debenture  shall be redeemed by the Company in accordance  with Section 5(a).
   Notwithstanding  anything  herein  to  the  contrary,  concurrent  with  each
   delivery of Conversion  Shares to a holder  pursuant to this  Debenture,  the
   Company  shall pay (in Interest  Shares,  only if all terms,  conditions  and
   requirements  set forth in this Debenture  concerning  payment of interest in
   the form of  Interest  Shares are  satisfied,  or cash as  determined  by the
   Company) to such holder all  accrued and unpaid  interest on the  Outstanding
   Principal  Amount then being  converted  from the last date on which interest
   had been paid on such  Outstanding  Principal  Amount  through the Conversion
   Date.

b) Company's  Right to  Mandatory  Conversion.  Subject  to  Sections  11 and 26
   hereof, if at any time from and after the Original Issuance Date the Weighted
   Average Price of the Common Stock shall exceed 175% of the  Conversion  Price
   for any 25  consecutive  trading days (the  "Mandatory  Conversion  Measuring
   Period"),  the Company may deliver on or before the second (2nd) Business Day
   following  the end of the  Mandatory  Conversion  Measuring  Period a written
   notice to all, but not less than all, of the Holders and the  Transfer  Agent
   (as  defined  in  Section  4(e)(i))  (the  "Mandatory   Conversion  Notice"),
   indicating  that the  Company is  requiring  each  Holder to convert the then
   Outstanding  Principal  Amount of such  Holder's  Debenture  plus accrued and
   unpaid  interest  thereon to the date fixed for  conversion  into fully paid,
   validly issued and  nonassessable  shares of Common Stock in accordance  with
   Section 4(d) hereof at the  Conversion  Rate as of the  Mandatory  Conversion
   Date (as defined below); provided,  however, that the Company may not require
   such conversion if (i) an Event of Default shall have occurred at any time on
   or prior to the  Mandatory  Conversion  Date and shall have not been cured to
   the reasonable  satisfaction of the holder of this  Debenture,  (ii) an event
   shall  have  occurred  and be  continuing  at any  time  on or  prior  to the
   Mandatory  Conversion  Date which with the passage of time and the failure to
   cure would result in an Event of Default,  (iii) either (A) any  Registration
   Statement is not  effective and available for the sale of at least all of the
   Registrable  Securities  (as defined in the  Registration  Rights  Agreement)
   required to be included in such Registration  Statement or (B) there has been
   any Grace  Period,  in either  case on any  trading  day  during  the  period
   beginning on the first day of the Mandatory  Conversion  Measuring Period and
   ending  on the  Mandatory  Conversion  Date or (iv)  there  has been a public
   announcement  of a pending,  proposed or intended  Change of Control,  unless
   such  pending,  proposed or intended  Change of Control has been  terminated,
   abandoned  or  consummated  and  the  Company  has  publicly  announced  such
   termination,  abandonment  or  consummation  of such  Change  of  Control  (a
   "Mandatory  Conversion").  The Company  shall send the  Mandatory  Conversion
   Notice by facsimile and overnight  courier to each Holder and shall  indicate
   (X) the date fixed for conversion,  which shall be not less than fifteen (15)
   days nor more than  thirty  (30) days  after  each  Holder's  receipt  of the
   Mandatory  Conversion  Notice  (the  "Mandatory  Conversion  Date"),  (Y) the
   Conversion Price and (Z) the number of shares of Common Stock to be issued to
   such Holder as of the Mandatory Conversion Date. If the Company has elected a
   Mandatory  Conversion,  the mechanics of conversion set forth in Section 4(e)
   shall  apply,  to the extent  applicable,  as if the Company and the Transfer
   Agent had  received  from  each  Holder on the  Mandatory  Conversion  Date a
   Conversion  Notice (as defined below) with respect to the entire  Outstanding
   Principal Amount of the Debenture and the interest accrued and unpaid thereon
   as of  the  Mandatory  Conversion  Date.  Promptly  following  the  Mandatory
   Conversion  Date, the Holder shall  surrender its Debenture to the Company or
   the Transfer Agent.

c) Partial  Conversion of Debenture.  If this  Debenture is converted in part,
   the  remaining  portion of this  Debenture  not so  converted  shall remain
   entitled to the conversion rights provided herein.

d) Conversion  Price for Holder  Converted  Shares.  The  Outstanding  Principal
   Amount of this  Debenture that is converted into shares of Common Stock shall
   be  convertible  into the number of shares of Common Stock which results from
   application of the following formula:

                                        P
                                ----------------
                                Conversion Price

   P = Outstanding Principal Amount of this Debenture submitted for conversion

The number of shares of Common  Stock into  which this  Debenture  hereto may be
converted  pursuant to the  foregoing  formula is  hereafter  referred to as the
"Conversion Rate."

e) Mechanics of Conversion.  The conversion of this Debenture shall be
   conducted in the following manner:


     i.   Holder's Delivery Requirements. To convert this Debenture (in whole or
          in part)  into full  shares of Common  Stock on any date,  the  Holder
          shall (A) transmit by facsimile (or otherwise physically deliver), for
          receipt on or prior to 5:00 p.m.,  New York City Time, on such date, a
          copy of a properly  completed  notice of  conversion  executed  by the
          Holder  in the form  attached  hereto as  Exhibit  I (the  "Conversion
          Notice") to the Company and the Company's  designated  transfer  agent
          (the  "Transfer  Agent") and (B) surrender  this Debenture to a common
          carrier for delivery to the Company as soon as  practicable  following
          such date.

     ii.  Company's  Response.  Upon  receipt  by the  Company  of a  copy  of a
          Conversion Notice,  the Company shall (A) as soon as practicable,  but
          in any event within two (2) Business  Days,  send,  via  facsimile,  a
          confirmation of receipt of such  Conversion  Notice to such holder and
          the Transfer Agent, which confirmation shall constitute an instruction
          to the Transfer Agent to process such Conversion  Notice in accordance
          with the terms  herein and (B) then,  on or before  the  second  (2nd)
          Business  Day  following  the date of receipt  by the  Company of such
          Conversion  Notice (the "Share Delivery Date"),  (x) issue and deliver
          to the address as specified in the Conversion  Notice,  a certificate,
          registered in the name of the Holder or its  designee,  for the number
          of shares of Common Stock to which the Holder  shall be  entitled,  or
          (y) in the  case of a  public  resale  of such  Conversion  Shares  in
          accordance  with the  provisions  of the  Irrevocable  Transfer  Agent
          Instructions,  provided the  Transfer  Agent is  participating  in The
          Depository  Trust Company ("DTC") Fast Automated  Securities  Transfer
          Program  and,  if  required  by DTC,  the holder  provides a customary
          representation  letter to DTC, upon the request of the holder,  credit
          such  aggregate  number of shares of Common  Stock to which the holder
          shall be entitled to the holder's  designee's balance account with DTC
          through  its  Deposit  Withdrawal  Agent  Commission  system.  If  the
          specified  principal  amount submitted for conversion is less than the
          then Outstanding Principal Amount of this Debenture,  then the Company
          shall, as soon as practicable using reasonable best efforts, and in no
          event later than five  Business  Days after  receipt of the  Debenture
          (the  "Debenture  Delivery  Date") and at its own  expense,  issue and
          deliver to the holder a new  Debenture  representing  the  Outstanding
          Principal Amount not converted.  The effective date of conversion (the
          "Conversion Date") shall be deemed to be the date on which the Company
          receives by facsimile the Conversion Notice, and the Person or Persons
          entitled  to receive  the shares of Common  Stock  issuable  upon such
          conversion  shall be treated for all purposes as the record  holder or
          holders of such shares of Common Stock on such date.

     iii. Dispute  Resolution.  In the case of a dispute as to the determination
          of the Closing Sale Price,  the Weighted Average Price, the Conversion
          Price  or the  arithmetic  calculation  of the  Conversion  Rate,  the
          Company shall  instruct the Transfer  Agent to issue to the Holder the
          number  of  shares  of Common  Stock  that is not  disputed  and shall
          transmit an explanation of the disputed  determinations  or arithmetic
          calculations to the Holder via facsimile  within two (2) Business Days
          of  receipt  of the  Holder's  Conversion  Notice  or  other  date  of
          determination.  If the Holder and the Company are unable to agree upon
          the  determination  of the Closing Sale Price,  the  Weighted  Average
          Price,  the  Conversion   Price  or  arithmetic   calculation  of  the
          Conversion  Rate  within  two  (2)  Business  Days  of  such  disputed
          determination  or  arithmetic  calculation  being  transmitted  to the
          Holder, then the Company shall within two (2) Business Days submit via
          facsimile  (A) the disputed  determination  of the Closing Sale Price,
          the Weighted Average Price or the Conversion Price, as applicable,  to
          an independent,  reputable investment bank selected by the Company and
          approved by the holders of at least 60% of the  Outstanding  Principal
          Amount of the  Debentures  issued on the Original  Issuance  Date then
          outstanding or (B) the disputed determination of the Conversion Price,
          the Weighted Average Price or the Conversion Price, as applicable,  or
          the disputed  arithmetic  calculation  of the  Conversion  Rate to the
          Company's independent, outside accountant. The Company shall cause the
          investment bank or the accountant,  as the case may be, to perform the
          determinations  or calculations and notify the Company and the holders
          of the results no later than ten (10)  Business  Days from the time it
          receives the disputed determinations or calculations.  Such investment
          bank's or accountant's  determination or calculation,  as the case may
          be, shall be binding upon all parties absent manifest error.

     iv.  Company's Failure to Timely Convert.


     A) If (x) within five (5) Business Days after the Company's  receipt of the
facsimile  copy of a  Conversion  Notice  the  Company  has  failed to issue and
deliver a  certificate  to a Holder or credit the  Holder's  designee's  balance
account  with DTC,  in  accordance  with  Section  4(e) hereof for the number of
shares  of Common  Stock to which  the  Holder  is  entitled  upon the  Holder's
conversion  of this  Debenture  or (y)  within  five  (5)  Business  Days of the
Company's  receipt of this Debenture the Company has failed to issue and deliver
a  Debenture  representing  the  principal  amount  of  this  Debenture  not  so
converted,  then in addition to all other  available  remedies which such holder
may pursue  hereunder and under the  Securities  Purchase  Agreement  (including
indemnification pursuant to Section 8 thereof), the Company shall pay additional
damages  to such  holder  for each day after the Share  Delivery  Date that such
conversion is not timely effected  and/or each day after the Debenture  Delivery
Date that this  Debenture  is not  delivered  in an amount equal to 0.05% of the
product of (I) the sum of the number of shares of Common Stock not issued to the
holder  on or prior to the  Share  Delivery  Date and to which  such  holder  is
entitled as set forth in the applicable  Conversion Notice and, in the event the
Company  has  failed to  deliver a  Debenture  to the  holder on or prior to the
Debenture  Delivery  Date,  the number of shares of Common Stock  issuable  upon
conversion  of this  Debenture as of the  Debenture  Delivery  Date and (II) the
Closing Sale Price of the Common Stock on the Share  Delivery  Date, in the case
of the failure to deliver Common Stock,  or the Debenture  Delivery Date, in the
case of failure to  deliver a  Debenture.  The  foregoing  notwithstanding,  the
damages set forth in this Section  4(e)(iv)  shall be stayed with respect to the
number of shares of Common Stock for which there is a good faith  dispute  being
resolved pursuant to Section 4(e)(iii), pending the resolution of such dispute.

     (B) If for any reason a holder has not received all of the shares of Common
Stock to which such holder is entitled  prior to the tenth  (10th)  Business Day
after the Share  Delivery Date with respect to a conversion  of this  Debenture,
then the Holder, upon written notice to the Company, with a copy to the Transfer
Agent, may void its Conversion Notice; provided that the voiding of the Holder's
Conversion  Notice  shall  not  affect  the  Company's  obligations  to make any
payments which have accrued prior to the date of such notice pursuant to Section
4(e)(iv)(A) or otherwise.

f) No Fractional  Shares. The Company shall not issue any fraction of a share of
Common Stock upon any  conversion.  If the issuance would result in the issuance
of a fraction of a share of Common Stock,  the Company shall round such fraction
of a share of Common Stock up or down to the nearest whole share.

g) Release of Funds from Segregated Account.  Notwithstanding anything herein to
the  contrary,  if at any time and from time to time,  the  balance of the funds
remaining  in the  Segregated  Account  (as defined in the  Securities  Purchase
Agreement),  if any, that were paid into the  Segregated  Account by the initial
holder of this Debenture, as set forth on the Schedule of Buyers attached to the
Securities Purchase Agreement,  exceeds the then Outstanding Principal Amount of
this Debenture,  together with accrued  interest thereon and so long as no Event
of Default, or event that with notice or lapse of time would constitute an Event
of Default, has occurred and is continuing, the holder agrees, by its acceptance
of this Debenture, to distribute promptly to the Company an amount in cash equal
to such excess from the Segregated Account  established by the initial holder of
this Debenture,  or, if advised in writing by the Company, to use such excess to
remit  payment for any  obligation  under this  Debenture  to the holder of this
Debenture.  If for any  reason any  portion of the funds held in the  Segregated
Account  established by the initial holder of this Debenture are not paid to the
Company in accordance  with the terms of the Securities  Purchase  Agreement and
the Outstanding  Principal  Amount on this Debenture,  together with accrued and
unpaid  interest  thereon,  becomes due and  payable  either at maturity or upon
acceleration or demand upon an Event of Default,  the Company and the holder, by
its  acceptance of this  Debenture,  agree that the funds held in the Segregated
Account shall be released to the holder of this Debenture and shall be deemed to
constitute  a  partial  payment  of the  Outstanding  Principal  Amount  of this
Debenture  together with accrued interest thereon then due in an amount equal to
the funds in the  Segregated  Account.  All such  payments  from the  Segregated
Account shall be deemed to be payments of (i) first, accrued and unpaid interest
on  the  Outstanding  Principal  Amount  of  this  Debenture  and  (ii)  second,
Outstanding Principal Amount of this Debenture.

h) Application of Conversion  Amounts.  Subject to the final sentence of Section
24(b),  any  portion  of this  Debenture  that the  Holder  elects to convert in
accordance  with this Section 4 shall be  deducted,  at the option of the Holder
(as set  forth  in the  applicable  Conversion  Notice),  either  (x)  from  the
Installment   Amount  relating  to  the  latest   Installment  Date  (i.e.,  the
Installment Date nearest to the Maturity Date) with respect to which Installment
Amounts remain  outstanding or (y) from the  Installment  Amount relating to the
nearest Installment Date (i.e., nearest to the Installment Date that has not yet
occurred).

5.       Redemption.

a) Mandatory  Redemption at Maturity.  If this Debenture remains  outstanding on
   the Maturity  Date,  the Company  shall redeem (a  "Maturity  Date  Mandatory
   Redemption")  the Outstanding  Principal Amount of this Debenture that is not
   subject  to a  Conversion  Notice for an amount in cash (the  "Maturity  Date
   Redemption Price") equal to the Outstanding Principal Amount of the Debenture
   not converted  into shares of Common Stock  pursuant to a Conversion  Notice,
   plus accrued and unpaid interest thereon.  The Maturity Date Redemption Price
   shall  be paid  on the  Maturity  Date to the  Holder  by  wire  transfer  of
   immediately  available  funds to an  account  designated  in  writing by such
   Holder. Promptly following payment of the Maturity Date Redemption Price, the
   Holder shall surrender this Debenture to the Company.

b) Payment  Failures If the Company fails to make any payment of a Maturity Date
   Redemption  Price,  then in  addition to any remedy the Holder may have under
   this Debenture, the Securities Purchase Agreement and the Registration Rights
   Agreement,  until the Maturity Date Redemption Price is paid in full, (x) the
   Maturity Date  Redemption  Price  payable in respect of such unpaid  Maturity
   Date  Redemption  Price  shall bear  interest  at the rate of 1.5% per month,
   prorated  for  partial  months,  and (y) the Holder  shall have the option to
   require the Company to convert any or all of the Outstanding Principal Amount
   of this  Debenture  subject to  redemption  and for which the  Maturity  Date
   Redemption Price (together with any interest  thereon) has not been paid into
   a number of shares of Common Stock equal to the quotient of the Maturity Date
   Redemption Price (together with any interest  thereon) divided by the Default
   Conversion Price.

6.  Anti-dilution  Adjustments to Conversion Price. The Conversion Price will be
subject to  adjustment  from time to time as provided  in this  Section 6 at all
times prior to, but not after,  the date on which cash collateral  payments have
been made  pursuant to Section 25 in an amount  equal to the entire  Outstanding
Principal  Amount,  together with accrued and unpaid  interest on all Debentures
outstanding:

a)  Anti-dilution  Adjustment of Conversion Price upon Issuance of Common Stock.
If and whenever on or after  January 26, 2004 and prior to the twelve (12) month
anniversary  of  Original  Issuance  Date,  the Company  issues or sells,  or in
accordance  with this Section 6(a) is deemed to have issued or sold,  any shares
of Common Stock (but excluding  shares of Common Stock:  (v) deemed to have been
issued by the Company in connection  with an Approved  Stock Plan; (w) deemed to
have been issued upon issuance of the Debentures  and the  debentures  issued on
January 26, 2004, pursuant to the Securities Purchase Agreement or the Warrants,
or issued upon conversion of the Debentures and the debentures issued on January
26,  2004,  pursuant to the  Securities  Purchase  Agreement  or exercise of the
Warrants;  (x) issued upon exercise of Options or Convertible  Securities  which
are outstanding on the date  immediately  preceding  January 26, 2004,  provided
that (except with regard to the Previously-Issued  Securities (as defined in the
Securities  Purchase  Agreement))  such  issuance of shares of Common Stock upon
exercise of such Options or Convertible Securities is made pursuant to the terms
of such  Options or  Convertible  Securities  in effect on the date  immediately
preceding  January 26, 2004,  such  Options or  Convertible  Securities  are not
amended after the date immediately  preceding  January 26, 2004, other than with
respect to Options  originally issued pursuant to an Approved Stock Plan and the
purchase or exercise  price  provided for in any such  Options,  the  additional
consideration,  if any, payable upon the issue, conversion, exchange or exercise
of any  such  Convertible  Securities,  or the  rate at  which  any  Convertible
Securities are convertible  into or exchangeable or exercisable for Common Stock
does not change at any time after  January  26,  2004;  (y) issued to the public
pursuant to an underwritten  offering  registered pursuant to the Securities Act
(but in all events  excluding  offerings  pursuant to "equity  lines" or similar
products);  and (z) issued  pursuant to a Strategic  Financing  ((v) through (z)
collectively  "Excluded  Issuances"))  for a  consideration  per share (the "New
Securities Issuance Price") less than the Conversion Price in effect immediately
prior to such time (each such sale or  issuance,  a "Dilutive  Issuance"),  then
concurrent with such Dilutive Issuance,  the Conversion Price then in effect (or
the initial  Conversion Price in case such Dilutive Issuance occurs prior to the
issuance  of this  Debenture)  shall be  reduced  to an amount  equal to the New
Securities  Issuance  Price.  If and  whenever on or after the twelve (12) month
anniversary  of the Original  Issuance Date and prior to the Maturity  Date, the
Company  issues or sells,  or in accordance  with this Section 6(a) is deemed to
have issued or sold, any shares of Common Stock (but excluding  shares of Common
Stock issued or deemed to have been issued pursuant to any Excluded Issuance) in
a Dilutive Issuance, then concurrent with such Dilutive Issuance, the Conversion
Price  then in effect (or the  initial  Conversion  Price in case such  Dilutive
Issuance occurs prior to the issuance of this  Debenture)  shall be reduced to a
price  (rounded to the nearest cent) equal to the product of (A) the  Conversion
Price in effect immediately prior to such Dilutive Issuance and (B) the quotient
determined by dividing (1) the sum of (I) the product derived by multiplying the
Conversion Price in effect  immediately  prior to such Dilutive Issuance and the
number of shares of Common Stock Deemed  Outstanding  immediately  prior to such
Dilutive Issuance plus (II) the  consideration,  if any, received by the Company
upon such Dilutive  Issuance,  by (2) the product derived by multiplying (I) the
Conversion Price in effect  immediately  prior to such Dilutive Issuance by (II)
the number of shares of Common Stock Deemed  Outstanding  immediately after such
Dilutive  Issuance.  For purposes of determining the adjusted  Conversion  Price
under this Section 6(a), the following shall be applicable:

     i.   Issuance of Options.  If the Company in any manner grants or sells any
          Options  and the lowest  price per share for which one share of Common
          Stock  is  issuable  upon the  exercise  of any  such  Option  or upon
          conversion,   exchange  or  exercise  of  any  Convertible  Securities
          issuable  upon  exercise  of such  Option is less than the  Conversion
          Price in effect immediately prior to such Dilutive Issuance, then such
          share of Common  Stock shall be deemed to be  outstanding  and to have
          been  issued and sold by the  Company at the time of the  granting  or
          sale of such  Option for such price per share.  For  purposes  of this
          Section  6(a)(i),  the "lowest  price per share for which one share of
          Common Stock is issuable  upon the exercise of any such Option or upon
          conversion,   exchange  or  exercise  of  any  Convertible  Securities
          issuable  upon  exercise of such Option"  shall be equal to the sum of
          the lowest amounts of consideration (if any) received or receivable by
          the  Company  with  respect  to any one  share of  Common  Stock  upon
          granting or sale of the Option,  upon  exercise of the Option and upon
          conversion,  exchange or exercise of any Convertible Security issuable
          upon exercise of such Option. No further  adjustment of the Conversion
          Price shall be made upon the actual  issuance of such Common  Stock or
          of such  Convertible  Securities  upon the exercise of such Options or
          upon  the  actual  issuance  of such  Common  Stock  upon  conversion,
          exchange or exercise of such Convertible Securities.

     ii.  Issuance  of  Convertible  Securities.  If the  Company  in any manner
          issues or sells any  Convertible  Securities  and the lowest price per
          share  for  which one  share of  Common  Stock is  issuable  upon such
          conversion,  exchange or exercise  thereof is less than the Conversion
          Price in effect immediately prior to such Dilutive Issuance, then such
          share of Common  Stock shall be deemed to be  outstanding  and to have
          been  issued and sold by the  Company at the time of the  issuance  of
          sale of such Convertible  Securities for such price per share. For the
          purposes of this  Section  6(a)(ii),  the "lowest  price per share for
          which one  share of Common  Stock is  issuable  upon such  conversion,
          exchange or exercise"  shall be equal to the sum of the lowest amounts
          of  consideration  (if any) received or receivable by the Company with
          respect to any one share of Common  Stock upon the issuance or sale of
          the Convertible Security and upon the conversion, exchange or exercise
          of such Convertible  Security. No further adjustment of the Conversion
          Price shall be made upon the actual issuance of such Common Stock upon
          conversion,  exchange or exercise of such Convertible Securities,  and
          if any such issue or sale of such Convertible  Securities is made upon
          exercise of any Options for which  adjustment of the Conversion  Price
          had  been or are to be  made  pursuant  to  other  provisions  of this
          Section 6(a), no further  adjustment of the Conversion  Price shall be
          made by reason of such issue or sale.

     iii. Change in  Option  Price or Rate of  Conversion.  If the  purchase  or
          exercise   price   provided  for  in  any  Options,   the   additional
          consideration, if any, payable upon the issue, conversion, exchange or
          exercise  of any  Convertible  Securities,  or the rate at  which  any
          Convertible   Securities  are  convertible  into  or  exchangeable  or
          exercisable for Common Stock changes at any time, the Conversion Price
          in  effect  at the  time of  such  change  shall  be  adjusted  to the
          Conversion Price which would have been in effect at such time had such
          Options or Convertible  Securities  provided for such changed purchase
          price,  additional  consideration  or changed  conversion rate, as the
          case may be,  at the  time  initially  granted,  issued  or sold.  For
          purposes  of this  Section  6(a)(iii),  if the terms of any  Option or
          Convertible  Security that was  outstanding as of the date of issuance
          of  the  Debentures  are  changed  in  the  manner  described  in  the
          immediately  preceding  sentence,  then  such  Option  or  Convertible
          Security  and  the  Common  Stock  deemed   issuable  upon   exercise,
          conversion or exchange  thereof shall be deemed to have been issued as
          of the  date of  such  change.  No  adjustment  shall  be made if such
          adjustment would result in an increase of the Conversion Price then in
          effect.

     iv.  Calculation of Consideration Received. In case any Option is issued in
          connection with the issue or sale of other  securities of the Company,
          together  comprising one  integrated  transaction in which no specific
          consideration  is allocated  to such  Options by the parties  thereto,
          then solely for purposes of this Section 6, the Options will be deemed
          to have been issued for a consideration of $0.01. If any Common Stock,
          Options or Convertible Securities are issued or sold or deemed to have
          been issued or sold for cash, the consideration received therefor will
          be deemed to be the gross amount received by the Company therefor.  If
          any Common Stock, Options or Convertible Securities are issued or sold
          for a consideration  other than cash, the amount of the  consideration
          other than cash received by the Company will be the fair value of such
          consideration,  except where such consideration consists of marketable
          securities,  in which case the amount of consideration received by the
          Company will be the  arithmetic  average of the Closing Sale Prices of
          such securities during the ten (10) consecutive trading days ending on
          the  date of  receipt  of  such  securities.  The  fair  value  of any
          consideration other than cash or securities will be determined jointly
          by the  Company  and the  holders  of at least 60% of the  Outstanding
          Principal  Amount of the  Debentures  issued on the Original  Issuance
          Date then  outstanding.  If such parties are unable to reach agreement
          within  ten (10)  days  after  the  occurrence  of an event  requiring
          valuation   (the   "Valuation   Event"),   the  fair   value  of  such
          consideration  will be determined  within five Business Days after the
          tenth (10th) day  following  the  Valuation  Event by an  independent,
          reputable  appraiser  selected  by the  Company  and the holders of at
          least 60% of the Outstanding Principal Amount of the Debentures issued
          on the Original Issuance Date then  outstanding.  The determination of
          such  appraiser  shall  be  deemed  binding  upon all  parties  absent
          manifest  error and the fees and expenses of such  appraiser  shall be
          borne by the Company.

     v.   Record  Date.  If the Company  takes a record of the holders of Common
          Stock for the purpose of  entitling  them (A) to receive a dividend or
          other  distribution  payable in Common Stock,  Options or  Convertible
          Securities or (B) to subscribe for or purchase  Common Stock,  Options
          or Convertible Securities,  then such record date will be deemed to be
          the date of the issue or sale of the shares of Common  Stock deemed to
          have been issued or sold upon the  declaration of such dividend or the
          making of such other  distribution or the date of the granting of such
          right of subscription or purchase, as the case may be.

(b)  Adjustment of Conversion  Price upon  Subdivision  or Combination of Common
Stock.  If the  Company  at any  time  subdivides  (by any  stock  split,  stock
dividend,  recapitalization or otherwise) its outstanding shares of Common Stock
into a greater  number of shares,  the  Conversion  Price in effect  immediately
prior to such subdivision (or the initial Conversion Price in case such Dilutive
Issuance occurs prior to the issuance of this Debenture) will be proportionately
reduced.  If the Company at any time  combines (by  combination,  reverse  stock
split or otherwise) its outstanding shares of Common Stock into a smaller number
of  shares  and  the  Conversion  Price  in  effect  immediately  prior  to such
combination will be proportionately increased.

(c)  Holder's  Right of  Alternative  Conversion  Price  Following  Issuance  of
Convertible  Securities.   If  the  Company  issues  or  sells  any  Options  or
Convertible  Securities  after the Original  Issuance Date that are  convertible
into or  exchangeable or exercisable for Common Stock at a price which varies or
may vary with the market price of the Common  Stock,  including by way of one or
more reset(s) to a fixed price (each of the formulations for such variable price
being herein  referred to as, the "Variable  Price"),  the Company shall provide
written  notice  thereof via facsimile and overnight  courier to the Holder (the
"Variable  Notice") on the date of issuance of such  Convertible  Securities  or
Options.  From and  after  the  date the  Company  issues  any such  Convertible
Securities  or  Options  with a  Variable  Price,  but  only for so long as such
Convertible  Securities  or Options are  outstanding,  the Holder shall have the
right, but not the obligation, in its sole discretion to substitute the Variable
Price for the Conversion  Price upon  conversion of any Debentures held by it by
designating  in  the  Conversion   Notice  delivered  upon  conversion  of  such
Debentures  that solely for purposes of such conversion the Holder is relying on
the Variable Price rather than the Conversion Price then in effect. The Holder's
election to rely on a Variable  Price for a particular  conversion of Debentures
shall not  obligate  the  Holder  to rely on a  Variable  Price  for any  future
conversions of Debentures.

(d) Other Events. If any event occurs of the type contemplated by the provisions
of this Section 6 in a private  transaction  (the primary purpose of which is to
raise  equity  capital)  but  not  expressly  provided  for by  such  provisions
(including,  without  limitation,  the  granting of stock  appreciation  rights,
phantom stock rights or other rights with equity features other than pursuant to
an  Excluded  Issuance),  then the  Company's  Board of  Directors  will make an
appropriate  adjustment in the  Conversion  Price so as to protect the rights of
the holders of the  Debentures;  provided that no such  adjustment will increase
the Conversion Price as otherwise determined pursuant to this Section 6.

(e)      Notices.
         -------

     Promptly  following any adjustment of the Conversion Price pursuant to this
Section 6, the Company will give written notice  thereof to the Holder,  setting
forth in reasonable detail, and certifying,  the calculation of such adjustment.
In the case of a dispute as to the  determination of such adjustment,  then such
dispute shall be resolved in accordance with the procedures set forth in Section
4(e)(iii).

     The  Company  will  give  written  notice  to the  Holder at least ten (10)
Business Days prior to the date on which the Company closes its books or takes a
record (A) with respect to any dividend or  distribution  upon the Common Stock,
(B) with respect to any pro rata  subscription  offer to holders of Common Stock
or (C) for  determining  rights to vote with  respect to any Organic  Change (as
defined in Section 7(a)), dissolution or liquidation,  provided that the Company
need not in any case provide such notice prior to the time such  information  is
made known to the public.

     The Company will also give  written  notice to the Holder at least ten (10)
Business  Days prior to the date on which any  Organic  Change,  dissolution  or
liquidation  will take place,  provided  that the  Company  need not in any case
provide  such  notice  prior to the time such  information  is made known to the
public.

7.       Other Rights.
         ------------

(a)  Reorganization,  Reclassification,   Consolidation,  Merger  or  Sale.  Any
recapitalization,  reorganization, reclassification, consolidation, merger, sale
of all or  substantially  all of the Company's assets to another Person or other
transaction  which is  effected in such a way that  holders of Common  Stock are
entitled to receive  (either  directly or upon  subsequent  liquidation)  stock,
securities or assets with respect to or in exchange for Common Stock is referred
to herein as "Organic  Change." Prior to the consummation of any (i) sale of all
or  substantially  all of the  Company's  assets to an acquiring  Person or (ii)
other Organic Change following which the Company is not a surviving entity,  the
Company will secure from the Person purchasing such assets or the successor, or,
if applicable,  the parent of the successor,  resulting from such Organic Change
(in each case,  the "Acquiring  Entity") a written  agreement to deliver to each
holder of  Outstanding  Principal  Amount of the Debentures in exchange for such
securities, a security of the Acquiring Entity evidenced by a written instrument
substantially  similar in form and substance to the  Debentures,  and reasonably
satisfactory to the holders of at least 60% of the Outstanding  Principal Amount
of the  Debentures  issued  on the  Original  Issuance  Date  then  outstanding;
provided that the new security of the Acquiring  Entity shall not be required to
be of rank equal to the  Debenture if the issuance of a security of such rank is
not permitted by, or is inconsistent  with, any agreement or instrument to which
the Acquiring  Entity is a party or any security of the Acquiring Entity that is
outstanding,  upon  the  consummation  of  the  Organic  Change.  Prior  to  the
consummation  of any other Organic  Change,  the Company shall make  appropriate
provision to insure that each of the holders of the Debentures  will  thereafter
have the right to acquire  and receive in lieu of or in addition to (as the case
may be) the  shares of  Common  Stock  immediately  theretofore  acquirable  and
receivable upon the conversion of such holder's Debentures such shares of stock,
securities  or assets  that  would have been  issued or payable in such  Organic
Change with  respect to or in exchange  for the number of shares of Common Stock
which would have been  acquirable  and  receivable  upon the  conversion of such
holder's  Debentures as of the date of such Organic Change  (without taking into
account  any  limitations  or  restrictions   on  the   convertibility   of  the
Debentures).

(b) Optional Redemption at Holder's Election Upon Change of Control. In addition
to the rights of the holders of Debentures under this Debenture,  the Securities
Purchase  Agreement  and the  Registration  Rights  Agreement,  upon a Change of
Control (as defined  below) of the Company each holder of Debentures  shall have
the right,  at such holder's  option,  to require the Company to redeem all or a
portion of such holder's  Debentures at a price equal to 100% of the Outstanding
Principal  Amount of such  Debentures  plus the  product of (1) 1.75 and (2) the
dollar  amount of all  Interest  Payments  scheduled  to be paid  following  the
consummation  of the Change of Control and on or prior to the  Maturity  Date on
the  total  Outstanding  Principal  Amount  of the  Debentures  on the  date  of
consummation of the Change of Control ("Change of Control Redemption Price"). No
sooner  than 20  Business  Days nor later  than 10  Business  Days  prior to the
consummation of a Change of Control, but not prior to the public announcement of
such Change of Control,  the Company shall deliver  written  notice  thereof via
facsimile and overnight courier (a "Notice of Change of Control") to each holder
of Debentures. At any time during the period beginning after receipt of a Notice
of Change of  Control  (or,  in the event a Notice of Change of  Control  is not
delivered at least 10 Business Days prior to a Change of Control, at any time on
or after the date which is 10 Business  Days prior to a Change of  Control)  and
ending on the date one (1)  Business  Day prior to such Change of  Control,  any
holder of the Debentures then  outstanding may require the Company to redeem all
or a portion of the holder's  Debentures then outstanding by delivering  written
notice thereof via facsimile and overnight courier (a "Notice of Redemption Upon
Change of Control") to the Company,  which Notice of  Redemption  Upon Change of
Control shall  indicate (i) the  principal  amount of the  Debentures  that such
holder is submitting for redemption,  and (ii) the applicable  Change of Control
Redemption  Price,  as  calculated  pursuant  to this  Section  7(b).  Upon  the
Company's  receipt of a Notice(s) of Redemption  Upon Change of Control from any
holder of Debentures, the Company shall promptly, but in no event later than two
(2) Business Days  following  such receipt,  notify each holder of Debentures by
facsimile of the Company's  receipt of such Notice(s) of Redemption  Upon Change
of Control.  The Company shall  deliver to the holder of each  Debenture who has
delivered a Notice of Redemption upon Change of Control,  the applicable  Change
of Control Redemption Price  simultaneously  with the consummation of the Change
of Control  provided that a holder's  Debentures shall have been so delivered to
the Company.  For purposes of this Section 7(b),  "Change of Control" shall mean
(i) the consolidation,  merger or other business combination of the Company with
or into another Person (other than (A) a consolidation, merger or other business
combination in which holders of the Company's voting power  immediately prior to
the transaction  continue after the transaction to hold, directly or indirectly,
the  voting  power of the  surviving  entity or  entities  necessary  to elect a
majority of the members of the board of directors (or their  equivalent if other
than a corporation)  of such entity or entities,  or (B) pursuant to a migratory
merger  effected  solely  for  the  purpose  of  changing  the  jurisdiction  of
incorporation of the Company), (ii) the sale or transfer of all or substantially
all of the  Company's  assets,  or (iii) a tender or exchange  offer made to and
accepted by the holders of more than 50% of the  aggregate  voting  power of the
outstanding Common Stock.

(c) Optional Redemption At the Company's Election Upon Cash Transaction.  At any
time or times on or after the date the  Company  publicly  discloses  a pending,
proposed or intended Cash Transaction,  the Company shall have the right, in its
sole discretion,  to require that all, but not less than all, of the Outstanding
Principal  Amount of this Debenture be redeemed  ("Cash  Transaction  Redemption
Election") at a price equal to 100% of the Outstanding  Principal Amount of this
Debenture plus the product of (1) 1.75 and (2) the dollar amount of all Interest
Payments scheduled to be paid following the consummation of the Cash Transaction
and on or prior to the Maturity Date on the total  Outstanding  Principal Amount
of the Debentures  redeemed on the date of consummation of the Cash  Transaction
(the "Cash Transaction  Redemption Price"). The Company shall exercise its right
to make a Cash  Transaction  Redemption  Election  by  providing  each holder of
Debentures written notice ("Notice of Cash Transaction Redemption") by facsimile
or overnight  courier,  after the public  disclosure  of a proposed,  pending or
intended Cash  Transaction and at least ten (10) Business Days prior to the date
of consummation of the Cash Transaction ("Cash Transaction  Election  Redemption
Date"), which Cash Transaction Election Redemption Date shall be the date of the
consummation of the Cash Transaction.  The Notice of Cash Transaction Redemption
shall indicate the anticipated Cash Transaction Election Redemption Date. If the
Company has exercised its right of Cash Transaction Redemption Election then the
Outstanding Principal Amount of the Debenture at the time of the consummation of
the  Cash  Transaction  shall  be  redeemed  on the  Cash  Transaction  Election
Redemption  Date by  payment by or on behalf of the  Company  to each  holder of
Debentures of the applicable Cash  Transaction  Redemption Price concurrent with
the closing of the Cash Transaction.  All holders of Debentures shall thereupon,
if the Cash Transaction  Redemption Price has been paid,  except as specifically
set forth herein,  in the Securities  Purchase  Agreement or in the Registration
Rights  Agreement,  cease to have any rights with respect to the  Debentures and
within two (2)  Business  Days after the Cash  Transaction  Election  Redemption
Date, or such earlier date as the Company and holders of no less then 60% of the
Outstanding  Principal Amount of the Debentures  issued on the Original Issuance
Date mutually agree, shall surrender all Debentures to the Company.

(d) Right to Convert on an Organic  Change or Change of Control or  Agreement of
the Parties.  In addition to the foregoing,  following the  announcement  of any
Change of Control or other Organic Change following which the Company is not the
surviving  entity or  otherwise  upon the mutual  agreement  of the  Company and
holders of at least 60% of the  Outstanding  Principal  Amount of all Debentures
issued on the Original  Issuance  Date,  the Holder shall  continue  pursuant to
Section  4(a)  hereof to have the right to  convert  the  Outstanding  Principal
Amount  of this  Debenture  at the then  prevailing  Conversion  Rate  until the
Debenture is redeemed or otherwise converted pursuant to this Section 7.

8. Reservation of Stock Issuable Upon Conversion.  The Company shall, so long as
any of the Debentures are outstanding,  take all action necessary to reserve and
keep available out of its authorized and unissued  Common Stock,  solely for the
purpose of effecting the conversions of the Debentures, such number of shares of
Common Stock as shall from time to time be sufficient  to effect the  conversion
of all of the Debentures then outstanding; provided that the number of shares of
Common  Stock  so  reserved  shall at no time  prior  to the date on which  cash
collateral  payments have been made pursuant to Section 25 in an amount equal to
the entire  Outstanding  Principal  Amount,  together  with  accrued  and unpaid
interest on all Debentures outstanding be less than 135% of the number of shares
of Common Stock needed to provide for the issuance of the shares of Common Stock
upon  conversion of all of the Debentures  (without regard to any limitations on
conversion)  and the maximum  number of Interest  Shares  issuable over the full
term of the Debentures (assuming the Company paid the maximum amount of interest
permitted  to be paid in Interest  Shares over the full term of the  Debentures)
and  after  such time 100% of the  number  of shares of Common  Stock  needed to
provide for the issuance of the shares of Common Stock upon conversion of all of
the Debentures (without regard to any limitations on conversion).

9. No Reissuance of Debentures.  No Debentures acquired by the Company by reason
of redemption, purchase, conversion or otherwise shall be reissued, and all such
Debentures shall be retired. No additional Debentures (other than the Debentures
issued  pursuant to the Securities  Purchase  Agreement)  shall be authorized or
issued  without the  consent of the  holders of at least 60% of the  Outstanding
Principal Amount of the Debentures issued on the Original Issuance Date.

10. No Impairment. The Company shall not intentionally take any action
which would impair the rights and  privileges  of the  Debentures  set
forth herein or the Holders thereof.

11. Limitation on Beneficial  Ownership.  The Company shall not effect and shall
have no obligation  to effect any  conversion  of  Debentures,  and no holder of
Debentures  shall have the right to convert any  Debentures,  to the extent that
after giving  effect to such  conversion,  the  beneficial  owner of such shares
(together with such Person's affiliates) would have acquired, through conversion
of Debentures or otherwise, beneficial ownership of a number of shares of Common
Stock that  exceeds  4.99% of the number of shares of Common  Stock  outstanding
immediately  after  giving  effect  to  such  conversion.  For  purposes  of the
foregoing sentence, the number of shares of Common Stock beneficially owned by a
Person and its  affiliates  shall  include the number of shares of Common  Stock
issuable  upon   conversion  of  the  Debentures   with  respect  to  which  the
determination  of such  sentence is being made,  but shall exclude the number of
shares of Common  Stock  which  would be  issuable  upon (A)  conversion  of the
remaining,  nonconverted  Debentures beneficially owned by such Person or any of
its affiliates and (B) exercise or conversion of the  unexercised or unconverted
portion of any other securities of the Company  (including,  without limitation,
any warrants) subject to a limitation on conversion or exercise analogous to the
limitation  contained  herein  beneficially  owned by such  Person or any of its
affiliates.  Except as set forth in the preceding sentence, for purposes of this
Section 11, beneficial  ownership shall be calculated in accordance with Section
13(d) of the Securities  Exchange Act of 1934, as amended.  For purposes of this
Section 11, in determining  the number of outstanding  shares of Common Stock, a
holder may rely on the number of outstanding shares of Common Stock as reflected
in (1) the  Company's  most recent Form 10-Q,  Form 10-K or other public  filing
with the SEC, as the case may be, (2) a more recent public  announcement  by the
Company,  or (3) any other notice by the Company or its transfer  agent  setting
forth the number of shares of Common Stock outstanding. Upon the written request
of the Holder,  the Company shall  promptly,  but in no event later than two (2)
Business Days  following  the receipt of such notice,  confirm in writing to the
Holder the number of shares of Common Stock then  outstanding.  In any case, the
number of  outstanding  shares of Common Stock shall be determined  after giving
effect to conversions  of Debentures by the Holder and its affiliates  since the
date as of which such number of outstanding shares of Common Stock was reported.

12. Obligations Absolute. No provision of this Debenture shall alter
or impair the obligation of the Company, which is absolute and
unconditional, to pay the principal of, and interest on, this
Debenture at the time, place and rate, and in the manner, herein
prescribed.

13. Waivers of Demand,  Etc. The Company hereby  expressly waives (to the extent
permitted by  applicable  law) demand and  presentment  for  payment,  notice of
nonpayment,   protest,  notice  of  protest,  notice  of  dishonor,   notice  of
acceleration  or intent to accelerate,  bringing of suit and diligence in taking
any action to collect  amounts  called for  hereunder  and will be directly  and
primarily  liable  for the  payment  of all sums  owing and to be owing  hereon,
regardless  of and  without any  notice,  diligence,  act or omission as or with
respect to the collection of any amount called for hereunder.

14.  Replacement  Debentures.  In the event that any Holder notifies the Company
that  its  Debenture(s)  have  been  lost,  stolen  or  destroyed,   replacement
Debenture(s)  identical in all respects to the original Debenture(s) (except for
registration  number and Outstanding  Principal  Amount,  if different than that
shown on the  original  Debenture(s))  shall be  issued  by the  Company  to the
Holder,  provided  that the  Holder  executes  and  delivers  to the  Company an
agreement  reasonably  satisfactory to the Company to indemnify the Company from
any loss incurred by it in connection with such Debenture(s).

         14A.  Payment of  Expenses.  The Company  agrees to pay all  reasonable
expenses,  including  reasonable  attorneys'  fees, which may be incurred by the
Holder  in  successfully  enforcing  the  provisions  of this  Debenture  and/or
successfully  collecting  any amount due under this  Debenture,  the  Securities
Purchase Agreement,  the Security  Agreement,  the Account Control Agreement (as
defined in the Securities Purchase  Agreement),  the Warrants,  the Registration
Rights Agreement or any other Transaction Document.

15.      Defaults.  The following shall constitute "Events of Default":
         --------

(a)      Any Event of Default under any other Debenture; or

(b) The  suspension  from trading or failure of the Common Stock to be listed on
NASDAQ,  the ASE or the NYSE for more than an aggregate of ten (10) trading days
in any 365-day period; or

(c) Any money judgment  (including any arbitration award, but only if reduced to
a judgment),  writ or warrant of attachment, or similar process in excess of Two
Hundred and Fifty  Thousand  Dollars  ($250,000)  in the  aggregate,  net of any
applicable  insurance  coverage,  shall be entered or filed against the Company,
its  Subsidiaries  or any of their  properties  or other  assets and which shall
remain  unpaid,  unvacated,  unbonded and unstayed for a period of  seventy-five
(75) days; or

(d) The  Company  shall  default in the  payment  when due  (including,  without
limitation,  the  Company's  failure to pay any  redemption  payments or amounts
hereunder) of (i) interest on this  Debenture,  and such default shall  continue
for  thirty  (30)  calendar  days  after  the due  date  thereof,  or  (ii)  the
Outstanding Principal Amount of this Debenture; or

(e)  Any of the  representations  or  warranties  made  by  the  Company  herein
(including any Cash Collateral  Certificate delivered under Section 25(g)(iii)),
in the Securities Purchase Agreement,  the Warrants, the Security Agreement, the
Account Control Agreement,  any Mortgage,  the Registration  Rights Agreement or
any other  Transaction  Document shall be untrue in any material  respect at the
time made and such  condition  (to the  extent  capable  of being  cured)  shall
continue  uncured for a period of ten (10)  Business  Days after notice from the
Holder of such  condition;  and such breach of  representations  and warranties,
singly or in the aggregate,  would have a Material  Adverse Effect or materially
impair the ability of the Company to perform or satisfy its  obligations  to the
Holder pursuant to the Transaction Documents; or

(f) The  Company  shall fail to perform or observe in any  material  respect any
material  covenant  or  agreement  in the  Securities  Purchase  Agreement,  the
Security Agreement,  the Warrants,  any Mortgage, the Account Control Agreement,
the  Registration  Rights  Agreement,  this  Debenture or any other  Transaction
Document, including, without limitation, (i) the failure to honor any Conversion
Notice and deliver  shares  pursuant  thereto,  and such failure shall  continue
uncured for a period of ten (10)  Business  Days after notice from the Holder of
such  failure or (ii) the failure by the Company to comply with its  obligations
under Section 25(g) hereof, including, without limitation, (A) the obligation to
disclose  sufficient  and timely  information in its public filings with the SEC
for the holder to verify and  reconcile  Company  Consolidated  Revenues for the
relevant periods, as required by Section 25(g)(iv) hereof, (B) the obligation to
make  payments  timely as and when due and in the form of cash and/or  Repayment
Shares as provided thereunder,  (C) the failure of the Company to deliver timely
a  completed  Cash  Collateral  Certificate  in the manner  required  by Section
25(g)(v)  hereof and (D) the delivery by or on behalf of the Company of any Cash
Collateral  Certificate  to any holder of  Debentures  without the express prior
written consent of such holder; or

(g) The Company shall (i) become insolvent;  (ii) admit in writing its inability
to pay its debts  generally as they  mature;  (iii) make an  assignment  for the
benefit of creditors or commence proceedings for its dissolution;  or (iv) apply
for or consent to the appointment of a trustee, liquidator or receiver for it or
for a substantial part of its property or business; or

(h) A trustee,  liquidator or receiver shall be appointed for the Company or for
a substantial part of its property or business without its consent and shall not
be discharged within sixty (60) days after such appointment; or

(i) Any  governmental  agency  or any  court of  competent  jurisdiction  at the
instance of any governmental agency shall assume custody or control of the whole
or any substantial  portion of the properties or assets of the Company and shall
not be dismissed within sixty (60) days thereafter; or

(j) The Company  shall fail to pay any debt for borrowed  money or other similar
obligation or liability  ("Indebtedness")  (excluding  Indebtedness evidenced by
the Debentures,  Subordinated  Indebtedness and Pari Passu  Indebtedness) of the
Company,  or any  interest or premium  thereon,  when due  (whether by scheduled
maturity,  required  prepayment,  acceleration,  demand  or  otherwise),  in  an
outstanding  principal  amount  equal to or in  excess  of One  Million  Dollars
($1,000,000),  singly or in the aggregate and such failure shall  continue after
the applicable  grace period,  if any,  specified in the agreement or instrument
relating to such Indebtedness,  or any such Indebtedness of the Company shall be
declared  to be due and  payable,  or  required  to be prepaid  (other than by a
regularly scheduled required prepayment),  prior to the stated maturity thereof;
or

(k) The  Company  shall  fail to make any  payment  of  principal  in respect of
Subordinated  Indebtedness or Pari Passu Indebtedness or any interest or premium
thereon,   when  due  (whether  by  scheduled  maturity,   required  prepayment,
acceleration,  demand or  otherwise),  and such failure shall continue after the
applicable  grace  period,  if any,  specified in the  agreement  or  instrument
relating to such Subordinated  Indebtedness or Pari Passu  Indebtedness,  or any
such Subordinated  Indebtedness or Pari Passu  Indebtedness shall be declared to
be due and  payable,  or  required  to be  prepaid  (other  than by a  regularly
scheduled required prepayment), prior to the stated maturity thereof; or

(l) Bankruptcy,  reorganization,  insolvency or liquidation proceedings or other
similar  proceedings,  or relief under any bankruptcy law or any similar law for
the relief of debt  shall be  instituted  by or  against  the  Company  and,  if
instituted  against the Company,  shall not be dismissed  within sixty (60) days
after such  institution or the Company shall by any action or answer approve of,
consent  to,  or  acquiesce  in any such  proceedings  or admit to any  material
allegations of, or default in answering a petition filed in any such proceeding;
or

(m) Unless the  Company  shall have made cash  collateral  payments in an amount
equal to the entire  Outstanding  Principal  Amount of all Debentures,  together
with accrued and unpaid interest thereon,  in accordance with Section 25(g), the
Registration  Statement (as defined in the Registration Rights Agreement) is not
declared  effective by the SEC and available for the sale of at least all of the
Registrable Securities (as defined in the Registration Rights Agreement pursuant
to the terms of the Registration  Rights  Agreement)  required to be included in
such Registration Statement on or before July 26, 2004; or

(n) the Security Agreement,  any Mortgage (as defined in the Securities Purchase
Agreement) or any other security  document,  after delivery  thereof pursuant to
the Securities Purchase Agreement,  shall for any reason fail or cease to create
a valid and perfected and, except to the extent permitted by the terms hereof or
thereof,  first  priority  lien in favor of the  agent  for the  benefit  of the
holders of Debentures on any collateral purported to be covered thereby; or

(o) the Cash Collateral Account Bank shall fail to comply with any of
the terms of the Account Control Agreement;

(p) at any time  required  to be in full force and effect  under the  Securities
Purchase  Agreement,  the Letters of Credit  shall for any reason cease to be in
full force and effect other than in  accordance  with their express terms or any
issuer of any of the Letters of Credit  shall fail to maintain a Minimum  Rating
(as  defined  in the  Securities  Purchase  Agreement)  or fail to  perform  its
obligations  thereunder  or shall,  in writing,  repudiate  the Letter of Credit
issued by it or deny that its  obligations  thereunder  are valid,  binding  and
enforceable,  and such failure  shall  continue  uncured for a period of fifteen
(15) days after notice from the Holder of such failure;

(q) the report of the Company's auditors on the Company's  consolidated  audited
financial  statements  for the year ended December 31, 2003 shall have contained
any going concern qualification; or

(r) any material  damage to, or loss,  theft or destruction  of, any Collateral,
whether  or not  insured,  or  any  strike,  lockout,  labor  dispute,  embargo,
condemnation,  act of God or public enemy,  or other casualty which causes,  for
more  than  fifteen  (15)   consecutive   days,  the  cessation  or  substantial
curtailment  of revenue  producing  activities  at any material  facility of the
Company or any of its Subsidiaries.

Unless an Event of  Default  shall  have been  waived in  writing  by the Holder
(which  waiver  shall not be deemed to be a waiver of any  subsequent  default),
upon the  occurrence  of an Event of  Default,  and for so long as such Event of
Default shall be continuing, at the option of and on notice by the Holder to the
Company in writing and in the Holder's sole discretion,  the Holder may consider
this Debenture immediately due and payable, without presentment, demand, protest
or notice of any kind, all of which are hereby expressly waived, anything herein
or in any other  instruments  contained to the contrary  notwithstanding  to the
extent permitted by applicable law (provided,  however, that upon the occurrence
of any Event of Default  described in subsection (g), (h) or (l) above,  without
any notice to the Company or any act by the Holder or the Agent,  this Debenture
shall become due and payable automatically and immediately, without presentment,
demand,  protest or notice of any kind, all of which are expressly waived by the
Company,  anything herein or in any other  instrument  contained to the contrary
notwithstanding  to the extent  permitted by applicable law), and the Holder may
immediately,  and without expiration of any further period of grace, enforce any
and all of the  Holder's  rights  and  remedies  provided  herein,  or under the
Security Agreement, the Mortgages, the Account Control Agreement and the Letters
of Credit or any other  rights or  remedies  afforded by law. In such event this
Debenture  shall  be  redeemed  at a  redemption  price  equal  to  100%  of the
Outstanding Principal Amount of the Debenture,  plus accrued and unpaid interest
on this Debenture.  In addition to the foregoing,  upon an Event of Default, the
rate of interest on this Debenture,  shall, to the maximum extent of the law, be
permanently  increased by two percent  (2%) per annum  (i.e.,  from 7% to 9% per
annum)  commencing  on the  first day of the  thirty  (30) day  period  (or part
thereof) following the Event of Default;  and, solely in the case of an Event of
Default  triggered by a Conversion  Failure,  an additional two percent (2%) per
annum  commencing  on the first day of each of the second and third such  thirty
(30) day periods (or part  thereof);  and an additional  one percent (1%) on the
first  day of  each  consecutive  thirty  (30)  day  period  (or  part  thereof)
thereafter  until this  Debenture has been duly  converted or redeemed as herein
provided;  provided that in no event shall the rate of interest exceed the lower
of 20% or the highest rate permitted by applicable law. The Company shall within
one (1) Business Day notify each Holder of Debentures upon becoming aware of the
occurrence of any Event of Default (whether or not waived by any other Holder of
Debentures)  or of any action taken by any Holder of Debentures  with respect to
the occurrence of any Event of Default.

16. Savings  Clause.  In case any provision of this Debenture is held by a court
of competent  jurisdiction  to be  excessive  in scope or  otherwise  invalid or
unenforceable, such provision shall be adjusted rather than voided, if possible,
so that it is enforceable to the maximum extent  possible,  and the validity and
enforceability of the remaining provisions of this Debenture will not in any way
be affected or impaired thereby.

17. Entire  Agreement.  This  Debenture and the  agreements  referred to in this
Debenture constitute the full and entire understanding and agreement between the
Company  and the  Holder  with  respect  to the  subject  hereof.  Neither  this
Debenture nor any term hereof may be amended,  waived,  discharged or terminated
other than by a written instrument signed by the Company and the Holder.

18.  Assignment,  Etc. The Holder may, subject to compliance with the Securities
Purchase Agreement and to applicable federal and state securities laws, transfer
or assign  this  Debenture  or any portion  thereof and may pledge,  encumber or
transfer  its rights or interest in and to this  Debenture  or any part  hereof,
provided,  that such transfer or assignment of this Debenture does not result in
more than ten (10)  holders  of the total  Outstanding  Principal  Amount of all
Debentures and any such part or portion of this  Debenture  constitutes at least
10% of the Outstanding  Principal  Amount or such lesser amount if such transfer
involves the entire  Outstanding  Principal Amount then held by such transferor.
Any such  transfer or  assignment  shall only be  effective  upon the  Company's
receipt of written notice  thereof.  Each such assignee,  transferee and pledgee
shall have all of the rights of the Holder  under this  Debenture.  The  Company
agrees that, subject to compliance with the Securities Purchase Agreement, after
receipt by the Company of written  notice of assignment  from the Holder and the
Holder's assignee, all principal, interest and other amounts which are then, and
thereafter  become,  due under this  Debenture  shall be paid to such  assignee,
transferee or pledgee at the place of payment  designated  in such notice.  This
Debenture  shall be binding upon the Company and its  successors and shall inure
to the benefit of the Holder and its successors and registered assigns.

19. No Waiver. No failure on the part of the Holder to exercise, and no delay in
exercising,  any  right,  remedy or power  hereunder  shall  operate as a waiver
thereof,  nor shall any single or partial  exercise  by the Holder of any right,
remedy or power  hereunder  preclude  any other or future  exercise of any other
right,  remedy or power. Each and every right, remedy or power hereby granted to
the Holder or allowed it by law or other  agreement  shall be cumulative and not
exclusive of any other, and may be exercised by the Holder from time to time.

20. Notices. Unless otherwise provided herein, any notices, consents, waivers or
other  communications  required or permitted to be given under the terms of this
Debenture must be in writing and will be deemed to have been delivered: (i) upon
receipt,  when delivered  personally;  (ii) upon receipt, when sent by facsimile
(provided   confirmation  of  transmission  is  mechanically  or  electronically
generated and kept on file by the sending party);  or (iii) one (1) Business Day
after deposit with a nationally  recognized  overnight delivery service, in each
case  properly  addressed to the party to receive the same.  The  addresses  and
facsimile numbers for such communications shall be:

                           If to the Company:

                                    Hemispherx Biopharma, Inc.
                                    1617 JFK Boulevard
                                    Suite 660
                                    Philadelphia, PA 19103
                                    Telephone:       (215) 998-8000
                                    Facsimile:       (215) 998-1739
                                    Attention:       Chief Executive Officer

                           With a copy to:

                                    Ransom W. Etheridge, Esq.
                                    2610 Potters Road
                                    Suite 200
                                    Virginia Beach, VA  23452
                                    Telephone:       (757-486-0599
                                    Facsimile:       (757) 486-0792


If to a holder, to its address and facsimile number set forth on the Schedule of
Buyers  attached  to the  Securities  Purchase  Agreement,  with  copies to such
holder's  representatives  as set forth on the  Schedule  of Buyers,  or to such
other  address  and/or  facsimile  number  and/or to the attention of such other
person as the  recipient  party has  specified  by written  notice given to each
other party five (5) days prior to the  effectiveness  of such  change.  Written
confirmation  of receipt (A) given by the  recipient  of such  notice,  consent,
waiver or other communication,  (B) mechanically or electronically  generated by
the sender's  facsimile machine containing the time, date,  recipient  facsimile
number and an image of the first page of such  transmission or (C) provided by a
courier or overnight  courier  service shall be rebuttable  evidence of personal
service,  receipt by facsimile or receipt from a nationally recognized overnight
delivery   service  in  accordance   with  clause  (i),  (ii)  or  (iii)  above,
respectively.

21. Miscellaneous. Whenever the sense of this Debenture requires,
words in the singular shall be deemed to include the plural and words
in the plural shall be deemed to include the singular. Paragraph
headings are for convenience only and shall not affect the meaning of
this document.

22.  Choice of Law and Venue;  Waiver of Jury  Trial.  THIS  DEBENTURE  SHALL BE
CONSTRUED  UNDER THE LAWS OF THE STATE OF NEW YORK WITHOUT  REGARD TO PRINCIPLES
OF CONFLICTS OF LAW OR CHOICE OF LAW (OTHER THAN SECTION  5-1401 OF THE NEW YORK
GENERAL  OBLIGATIONS  LAW).  The parties hereto hereby agree that all actions or
proceedings  arising  directly or  indirectly  from or in  connection  with this
Debenture  shall be litigated only in the Supreme Court of the State of New York
or the  United  States  District  Court for the  Southern  District  of New York
located  in New York  County,  New  York.  The  parties  hereto  consent  to the
jurisdiction  and venue of the foregoing  courts and consent that any process or
notice  of  motion or other  application  to  either  of said  courts or a judge
thereof may be served  inside or outside  the State of New York or the  Southern
District of New York by registered mail, return receipt  requested,  directed as
provided in Section 20 (and  service so made shall be deemed  complete  five (5)
days after the same has been posted as aforesaid)  or by personal  service or in
such other  manner as may be  permissible  under the rules of said  courts.  The
parties  hereto  hereby waive any right to a jury trial in  connection  with any
litigation pursuant to this Debenture.

23. Rule 144. With a view to making available to the Holder the benefits of Rule
144  promulgated  under the Act ("Rule 144") and any other rule or regulation of
the SEC that may at any time permit the Holder to sell the  underlying  stock of
the Company  issuable  upon  conversion  or exercise of the  Debentures  and the
Warrants  to the public  without  registration,  the  Company  agrees to use its
reasonable best efforts to:

(a) make and keep public information available, as those terms are
understood and defined in Rule 144, at all times;

(b)  file  with the SEC in a timely  manner  all  reports  and  other  documents
required of the Company under the Act and the  Securities  Exchange Act of 1934,
as amended (the "Exchange Act"); and

(c) furnish to any Holder,  promptly  upon request,  a written  statement by the
Company  (provided  true at the time) that it has complied  with the  applicable
reporting and filing requirements of the Act and the Exchange Act, a copy of the
most recent annual or quarterly report of the Company,  and copies of such other
reports  and  documents  (if any) so filed by the  Company as may be  reasonably
requested to permit any such Holder to take  advantage of any rule or regulation
of the SEC permitting the selling of any such securities without registration.

24.      Company Installment Conversion or Redemption.
         --------------------------------------------

(a) General. On each Installment Date (unless waived by the Holder), the Company
shall  pay to the  Holder  of  this  Note  the  Installment  Amount  as of  such
Installment Date by the combination of any of the following,  but subject to and
in accordance with the terms of this Section 24, (i) requiring the conversion of
a  portion  of the  applicable  Installment  Amount,  in whole  or in  part,  in
accordance  with  this  Section  24  but  subject  to  the  satisfaction  of the
Conditions to Company  Conversion (as defined  below) (a "Company  Conversion"),
and/or (ii) redeeming the applicable Installment Amount, in whole or in part, in
accordance with this Section 24 (a "Company  Redemption");  provided that all of
the outstanding  applicable  Installment Amount as of each such Installment Date
must be converted  and/or redeemed by the Company on the applicable  Installment
Date,  subject to the  provisions  of this  Section  24. On or prior to the date
which is at least 2 Trading Days prior to each Installment Measuring Period, the
Company shall deliver written notice to the Holder (each, a "Company Installment
Notice"),  which Company Installment Notice shall state (i) the portion, if any,
of the  applicable  Installment  Amount  which the  Company  elects  to  convert
pursuant  to a  Company  Conversion,  which  amount  when  added to the  Company
Redemption  Amount must equal the  applicable  Installment  Amount (the "Company
Conversion  Amount"),  (ii) the portion,  if any, of the applicable  Installment
Amount which the Company elects to redeem pursuant to a Company  Redemption (the
"Company Redemption Amount"),  which amount when added to the Company Conversion
Amount must equal the applicable  Installment  Amount,  and (iii) if the Company
has  elected,  in whole or in  part,  a  Company  Conversion,  then the  Company
Installment  Notice shall certify that the Conditions to Company  Conversion are
satisfied as of the date of the Company  Installment Notice. If the Company does
not deliver a Company  Installment Notice in accordance with this Section 24(a),
then the "Company  Redemption  Amount" and the "Company  Conversion Amount" with
respect to such Installment Date shall be in such amounts and proportions as the
Holder shall  designate in writing to the Company in its sole discretion and the
Company shall be deemed to have delivered a Company  Installment  Notice setting
forth such amounts. Each Company Installment Notice shall be irrevocable. Except
as  expressly  provided in this  Section  24(a),  the Company  shall  redeem and
convert the applicable  Installment  Amount of this  Debenture  pursuant to this
Section 24 and the  corresponding  Installment  Amounts of the other  Debentures
pursuant to the  corresponding  provisions  of the other  Debentures in the same
ratio of the  Installment  Amount being  redeemed and converted  hereunder.  The
Company  Redemption Amount (whether set forth in the Company  Installment Notice
or by operation of this Section 24) shall be redeemed in accordance with Section
24(b), and the Company  Conversion  Amount shall be converted in accordance with
Section 24(c).

(b) Mechanics of Company Redemption. If the Company elects, or is deemed to have
elected, a Company Redemption in accordance with Section 24(a), then the Company
Redemption  Amount,  if any, which is to be paid to the Holder on the applicable
Installment Date shall be redeemed by the Company on such Installment  Date, and
the Company shall pay to the Holder on such  Installment  Date, by wire transfer
of  immediately  available  funds,  an amount in cash (the "Company  Installment
Redemption  Price") equal to the sum of 100% of the Company  Redemption  Amount.
Notwithstanding  anything to the contrary in this Section 24(b),  but subject to
Sections 11 and 26, until the Company  Installment  Redemption  Price  (together
with any  interest  thereon)  is paid in full,  the  Company  Redemption  Amount
(together  with  any  interest  thereon  permitted  hereunder  to be paid by the
Company in Common  Stock) may be  converted,  in whole or in part, by the Holder
into Common Stock pursuant to Section 4.

(c) Mechanics of Company Conversion. Subject to Sections 11 and 26 and Section
24(e),  if the Company  delivers a Company  Installment  Notice and elects or is
deemed to have elected,  in whole or in part, a Company Conversion in accordance
with Section 24(a), then the applicable Company Conversion Amount, if any, which
remains outstanding shall be converted as of the applicable  Installment Date by
converting on such  Installment  Date such Company  Conversion  Amount as if the
Holder had delivered a Conversion  Notice  pursuant to Section 4 with respect to
such Company  Conversion  Amount on such Installment Date but without the Holder
being required to actually  deliver such  Conversion  Notice;  provided that the
Conditions  to Company  Conversion  are  satisfied  (or waived in writing by the
Holder) on such  Installment  Date. If the Conditions to Company  Conversion are
not  satisfied  (or waived in writing by the Holder) on such  Installment  Date,
then at the option of the Holder  designated  in  writing  to the  Company,  the
Holder may require the Company to do any one or more of the  following:  (i) the
Company shall redeem all or any part designated by the Holder of the unconverted
Company  Conversion  Amount (such designated amount is referred to as the "First
Redemption  Amount") on such  Installment  Date and the Company shall pay to the
Holder on such  Installment  Date,  by wire  transfer of  immediately  available
funds,  an amount in cash equal to such  First  Redemption  Amount,  or (ii) the
Company  Conversion  shall  be null  and void  with  respect  to all or any part
designated by the Holder of the unconverted  Company  Conversion  Amount and the
Holder shall be entitled to all the rights of a holder of this Note with respect
to such amount of the Company  Conversion Amount. If the Company fails to redeem
any First  Redemption  Amount on the applicable  Installment  Date by payment of
such amount on the applicable  Installment  Date, then the Holder shall have the
rights set forth in Section 24(b) as if the Company failed to pay the applicable
Company  Redemption  Price  and all other  rights  under  this Note  (including,
without limitation,  such failure  constituting an Event of Default described in
Section  15(d)).  In the event the Holder  delivers a  Conversion  Notice to the
Company  after the earlier of the date which is 10 days prior to the  applicable
Installment Date and the Holder's receipt of the Company  Installment  Notice in
respect of such  Installment  Date in which the  Company  elects or is deemed to
have  elected a Company  Redemption,  the  Principal  amount  specified  in such
Conversion Notice shall be deducted (1) first, from the Principal represented by
the Company  Redemption  Amount and then (2) second,  in accordance with Section
4(e)(h).

(d) Conditions to Company Conversion. For purposes of this Section 24,
"Conditions to Company  Conversion" means (i) during the period beginning on the
Original  Issuance Date and ending on and including the  applicable  Installment
Date,  the  Company  shall  have  delivered  shares  of  Common  Stock  upon any
conversion  of  Conversion  Amounts  on a timely  basis as set forth in  Section
4(e)(ii) and analogous  provisions  under the other  Debentures,  and shall have
delivered shares of Common Stock upon exercise of any Warrants on a timely basis
as set forth in Section 2(a) of the Warrants; (ii) on each day during the period
beginning  on the  Original  Issuance  Date  and  ending  on and  including  the
applicable  Installment  Date, the Common Stock shall be listed on the Principal
Market  and  delisting  or  suspension  of the  Common  Stock by such  market or
exchange shall not have been threatened  either (A) in writing by such market or
exchange or (B) by falling below the minimum listing maintenance requirements of
such market or exchange for the Common Stock;  (iii) during the period beginning
on the  Original  Issuance  Date and  ending  on and  including  the  applicable
Installment   Date,  there  shall  not  have  occurred  either  (x)  the  public
announcement of a pending,  proposed or intended Change of Control which has not
been  abandoned,  terminated  or  consummated  or (y) an Event of Default;  (iv)
during the period beginning on the date which is the Original  Issuance Date and
ending on and including the applicable  Installment  Date,  there shall not have
occurred  an event  that  with the  passage  of time or giving  of  notice,  and
assuming it were not cured,  would  constitute an Event of Default;  (v) on each
day of the period  beginning  on the date of delivery  of a Company  Installment
Notice  with  respect  to an  Installment  Date  and  ending  on the  applicable
Installment  Date  either  (x)  the   Registration   Statement  or  Registration
Statements  required  pursuant to the  Registration  Rights  Agreement  shall be
effective and available for the resale of all of the  Registrable  Securities in
accordance  with and to the  extent  required  by the terms of the  Registration
Rights  Agreement or (y) all shares of Common Stock issuable upon  conversion of
the Debentures and shares of Common Stock issuable upon exercise of the Warrants
shall be eligible  for sale  without  restriction  (other  than any  restriction
arising under  applicable  federal or state  securities  laws as a result of the
holder of such  securities  being an  Affiliate  of the Company) and without the
need for  registration  under any applicable  federal or state  securities laws;
(vi) on each day of the period beginning on the applicable  Installment Date and
ending thirty Trading Days  thereafter  either (x) the  Registration  Statements
required  pursuant to the Registration  Rights Agreement shall be expected to be
effective  and  available  for the  resale  of at least  all of the  Registrable
Securities  in  accordance  with and to the extent  required by the terms of the
Registration  Rights  Agreement or (y) all shares of Common Stock  issuable upon
conversion of the  Debentures  and shares of Common Stock issuable upon exercise
of the Warrants shall be eligible for sale without  restriction  (other than any
restriction  arising  under  applicable  federal or state  securities  laws as a
result of the holder of such  securities  states as an Affiliate of the Company)
and  without the need for  registration  under any  applicable  federal or state
securities  laws;  and (vii) the Company  otherwise  shall have been in material
compliance  with and shall  not have  breached,  in any  material  respect,  any
provision,  covenant,  representation  or  warranty of the  Securities  Purchase
Agreement,  any of the  Warrants,  any of  the  Debentures  or any of the  other
Transaction Documents.

(e) Certain Definitions. For purposes of this Section 24, the following
capitalized terms shall have the following meanings:

(i) "Company Conversion Price" means, with respect to any Company
Conversion,  that price which shall be computed as 95% of the arithmetic average
of the  Weighted  Average  Price of the Common  Stock on each trading day in the
Installment Measuring Period.

(ii) "Installment Amount" means, with respect to any Installment Date, the
Outstanding  Principal  Amount  of this  Debenture  as of the  Installment  Date
divided by the number of full months between the  Installment  Date and June 30,
2007.  In the event the Holder shall sell or  otherwise  transfer any portion of
this  Debenture,  the  transferee  shall be  allocated a pro rata portion of the
Installment Amount.

(iii) "Installment Date" means each monthly anniversary of the Original
Issuance Date, commencing on January 1, 2007.

(iv) "Installment Measuring Period" means, with respect to an Installment
Date,  the 10-day  trading day period  commencing  on and including the eleventh
trading  day  immediately  preceding  such  Installment  Date and  ending on and
including the trading day immediately preceding such Installment Date.

25.      Rank; Covenants; Cash Collateral.
         --------------------------------

(a) Definitions. For purposes of this Section 25, the following terms
shall have the following meanings:

     (i)  "Acquisition  Buildings"  shall mean the buildings  being purchased by
          the Company in connection with the Interferon  Acquisition and located
          at 783 Jersey Avenue,  5 Jules Lane, New Brunswick  Middlesex Co., New
          Jersey.

     (ii) "Acquisition  Indebtedness"  shall  mean  any  Indebtedness  incurred,
          assumed or  guaranteed  by the Company or any of its  Subsidiaries  in
          respect of the purchase price for, or in connection  with the purchase
          of, any  assets,  business  or  securities  (an  "Acquired  Business")
          acquired  by  the  Company  or any of  its  Subsidiaries,  other  than
          Indebtedness  incurred,  assumed or guaranteed in connection  with the
          Interferon Acquisition.

     (iii)"Acquisition  Multiple"  shall  mean,  subject in all  respects to the
          final  sentence  of  Section  25(b)(i)  hereof,  (i) in the  event the
          Acquired  Business  is not a  Qualified  Competitor,  three  times the
          EBITDA of the  Acquired  Business  or (ii) in the  event the  Acquired
          Business  is a  Qualified  Competitor,  four  times the  EBITDA of the
          Acquired Business;  provided, however, that if prior to the closing of
          the acquisition of any Acquired Business under subsections (i) or (ii)
          of this definition,  the Company has not been furnished with financial
          statements  of such  Acquired  Business  that have been  audited  by a
          nationally recognized auditing firm, the Acquisition Multiple shall be
          two and one half (2 1/2) times the EBITDA of the Acquired Business.

     (iv) "Biweekly  Revenue Cash Collateral  Date" shall mean the 15th and last
          calendar day of each month during the Initial Cash Collateral  Period.
          If any Biweekly  Revenue Cash  Collateral  Date is not a Business Day,
          then the Biweekly  Revenue Cash  Collateral Date shall be the Business
          Day immediately following such Biweekly Revenue Cash Collateral Date.

     (v)  "Cash   Collateral   Date"  shall  mean  each  Biweekly  Revenue  Cash
          Collateral  Date,  Monthly  Revenue Cash  Collateral  Date,  the First
          Revenue  Milestone Cash Collateral Date, the Second Revenue  Milestone
          Cash  Collateral  Date, the Third Revenue  Milestone  Cash  Collateral
          Date,  the  Qualified  Inventory  Financing  Date  and  the  Qualified
          Mortgage Financing Date.

     (vi) "Company Consolidated Revenues" shall mean the aggregate amount of all
          cash collected by the Company and its Subsidiaries, including, without
          limitation,   cash  proceeds   from  the  sales  of  inventory,   cash
          collections  of accounts  receivable,  cash  collections  of licensing
          fees, cash proceeds from the issuance of all  Indebtedness  (excluding
          cash received for the purchase of the Debentures),  but excluding cash
          received  from  (a)  the  issuance  of any  equity  or  equity  linked
          securities of the Company,  (b) the Qualified  Mortgage  Financing and
          (c) the Qualified Inventory Financing.

     (vii)"EBITDA" shall mean (1) the earnings  before  interest,  income taxes,
          depreciation and amortization of the Acquired  Business for the twelve
          (12) full months immediately  preceding the closing date in respect of
          the   purchase  of  the  Acquired   Business   less  (2)  any  capital
          expenditures of the Acquired Business during such period.

     (viii) "First Revenue  Milestone Cash Collateral Date" shall mean March 31,
          2004.

     (ix) "First  Revenue  Milestone  Measuring  Period"  shall  mean the period
          commencing  on  January  1,  2004  and  ending  on the  First  Revenue
          Milestone Cash Collateral Date.

     (x)  "First Revenue Milestone Target" shall mean $800,000.00.

     (xi) "Initial Cash Collateral  Period" shall mean the period  commencing on
          and  including  April 15, 2004 and ending on and  including  April 29,
          2005.

     (xii)"Inventory"  shall mean,  with  respect to any  Person,  all goods and
          merchandise of such Person,  including,  without  limitation,  all raw
          materials,   work-in-process,   packaging,   supplies,  materials  and
          finished  goods of every nature used or usable in connection  with the
          shipping, storing,  advertising or sale of such goods and merchandise,
          whether now owned or hereafter  acquired,  and all such other property
          the sale or other  disposition  of which would give rise to an account
          receivable,  including, without limitation, all of the items listed on
          Exhibit B to this Debenture.

     (xiii)  "Lien"  shall  mean  any  mortgage,  deed of  trust,  pledge,  lien
          (statutory  or  otherwise),   security   interest,   charge  or  other
          encumbrance  or security or  preferential  arrangement  of any nature,
          including, without limitation, any conditional sale or title retention
          arrangement,  any  capitalized  lease  and  any  assignment,   deposit
          arrangement  or financing  lease intended as, or having the effect of,
          security.

     (xiv)"Monthly  Revenue Cash  Collateral  Date" shall mean the 30th calendar
          day of each month during the Secondary Cash Collateral  Period (except
          for the month of January 2005, which shall be the 31st calendar day of
          such month and the month of February, which shall be the 28th calendar
          day of such month). If any Monthly Revenue Cash Collateral Date is not
          a Business Day, then the Monthly Revenue Cash Collateral Date shall be
          the  Business Day  immediately  following  such  Monthly  Revenue Cash
          Collateral Date.

     (xv) "Pari  Passu  Indebtedness"  shall  mean  Indebtedness  that  is  made
          expressly  "pari passu" in right of payment with the  Debentures in an
          aggregate of (i) up to an aggregate  principal amount of $5,000,000 of
          Indebtedness,  (ii) up to an additional  aggregate principal amount of
          $5,000,000  of  Indebtedness  incurred at any time after the  eighteen
          (18) month anniversary of the Original Issuance Date, provided that in
          order to incur any Pari Passu  Indebtedness  pursuant  to this  clause
          (ii) the  arithmetic  average  of the  Weighted  Average  Price of the
          Common Stock on each trading day during the twenty consecutive trading
          day period prior to the incurrence of any such Pari Passu Indebtedness
          under this  clause  (ii) must equal or exceed  150% of the  Conversion
          Price then in effect,  (iii) up to an additional  aggregate  principal
          amount of  $4,000,000  of  Indebtedness  incurred  any time  after the
          Outstanding   Principal   Amount  of  all   Debentures  is  less  than
          $1,000,000;   provided,   that  in  order  to  incur  any  Pari  Passu
          Indebtedness  under this clause  (iii) the  arithmetic  average of the
          Weighted  Average Price of the Common Stock on each trading day during
          the twenty  consecutive  trading day period prior to the incurrence of
          any such Pari Passu Indebtedness under this clause (iii) must equal or
          exceed 150% of the  Conversion  Price then in effect (iv)  Acquisition
          Indebtedness,  and (v) any other indebtedness of the Company which the
          Company  and the  holders  of more  than 60% of the  then  Outstanding
          Principal  Amount of the  Debentures  issued on the Original  Issuance
          Date may hereafter from time to time expressly and specifically  agree
          in writing shall constitute Pari Passu Indebtedness.

     (xvi) "Permitted Liens" shall mean:

          (A)  Liens  securing  all  obligations  under the  Debentures  and the
          agreements and instruments entered into in connection therewith;

          (B) the Qualified Mortgage;

          (C) the Qualified Inventory Liens;

          (D) Liens on any  Intellectual  Property  of the Company or any of its
          Subsidiaries; and

          (E) Liens securing all  obligations  under the Company's  Series A and
          Series B 7% Senior  Secured  Convertible  Debentures Due June 30, 2007
          and  the  agreements  and  instruments   entered  into  in  connection
          therewith.



     (xvii)  "Qualified  Competitor"  shall mean an  Acquired  Business  that is
          competitive  with  and in the same  business  with a  business  of the
          Company  or any of its  Subsidiaries,  where  the  Company's  Board of
          Directors determines,  in its reasonable judgment,  that substantially
          all  overhead  expenses of the Acquired  Business  during the trailing
          twelve months  immediately  preceding the acquisition of such Acquired
          Business are duplicative with overhead  expenses of the Company or any
          of such Subsidiaries and such duplicative  expenses will be eliminated
          within  six (6)  months  immediately  following  the  purchase  of the
          Acquired Business.

     (xviii) "Qualified Indebtedness" shall mean Pari Passu Indebtedness that is
          not evidenced by any certificate,  instrument, note or other agreement
          that, directly or indirectly, permits or requires such Indebtedness to
          be convertible  into or exercisable or  exchangeable  for Common Stock
          (other than Options that may be issued by the Company to the holder(s)
          of such  Indebtedness,  the value of which  does not exceed 10% of the
          principal amount of Indebtedness so incurred,  as determined using the
          Black-Scholes valuation methodology).

     (xix)"Qualified   Inventory   Financing"  shall  mean  a  single  financing
          arrangement  pursuant  to which the  Company  and/or its  Subsidiaries
          obtains  financing  solely  through the granting of Liens on Inventory
          that yield total net unrestricted  cash proceeds to the Company at the
          time of the creation of such Liens of not less than $2,000,000.00.

     (xx) "Qualified  Inventory Financing Date" shall mean the date on which the
          Qualified Inventory Financing is consummated.

     (xxi)"Qualified  Inventory  Liens" shall mean Liens on  Inventory  that are
          created or imposed  solely in  connection  with a Qualified  Inventory
          Financing.

     (xxii)  "Qualified  Mortgage"  shall  mean a  mortgage  on the  Acquisition
          Buildings  that is  created  or imposed  solely in  connection  with a
          Qualified Mortgage Financing.

     (xxiii)  "Qualified  Mortgage  Financing"  shall  mean a  single  financing
          arrangement pursuant to which the Company either (i) obtains financing
          solely through the granting of Liens on the  Acquisition  Buildings or
          (ii) sells the  Acquisition  Building,  in each case in a  transaction
          that yields total net unrestricted cash proceeds to the Company at the
          time of the  creation  of such Liens or at the time of such  sale,  as
          applicable, of not less than $1,500,000.00.

     (xxiv) "Qualified Mortgage Financing Date" shall mean the date on which the
          Qualified Mortgage Financing is consummated.

     (xxv)"Secondary  Cash Collateral  Period" shall mean the period  commencing
          on and  including  April  30,  2005 and  ending on and  including  the
          Maturity Date.

     (xxvi) "Second Revenue  Milestone Cash Collateral Date" shall mean June 30,
          2004; provided that if such day is not a Business Day, then the Second
          Revenue  Milestone  Cash  Collateral  Date shall be the  Business  Day
          immediately  following the Second Revenue  Milestone  Cash  Collateral
          Date.

     (xxvii) "Second Revenue  Milestone  Measuring Period" shall mean the period
          commencing  on  January  1,  2004 and  ending  on the  Second  Revenue
          Milestone Cash Collateral Date.

     (xxviii)  "Second  Revenue  Milestone  Target"  shall  mean  $1,500,000.00.

     (xxix) "Third Revenue  Milestone Cash Collateral  Date" shall mean December
          31 2004;  provided  that if such day is not a Business  Day,  then the
          Third Revenue Milestone Cash Collateral Date shall be the Business Day
          immediately  following the Third  Revenue  Milestone  Cash  Collateral
          Date.

     (xxx)"Third  Revenue  Milestone  Measuring  Period"  shall  mean the period
          commencing  on  January  1,  2004  and  ending  on the  Third  Revenue
          Milestone Cash Collateral Date.

     (xxxi) "Third Revenue Milestone Target" shall mean $3,000,000.00.

(b)                   Incurrence of Indebtedness.
                      --------------------------

     i.   So long as any of the Debentures are  outstanding  and cash collateral
          payments  have  not  been  made  in an  amount  equal  to  the  entire
          Outstanding  Principal  Amount and accrued and unpaid  interest on all
          Debentures  pursuant to Section 25(g),  the Company shall not, and the
          Company  shall not  permit any of its  Subsidiaries  to,  directly  or
          indirectly,  incur  or  guarantee,  assume  or  suffer  to  exist  any
          Indebtedness,  other  than  (A)  the  Indebtedness  evidenced  by  the
          Debentures  which shall rank ratably and equally with each other,  (B)
          Pari  Passu  Indebtedness  that is not  secured  by any  assets of the
          Company or any of its  Subsidiaries  and that does not  provide at any
          time for the payment of any  principal  thereon until at least 91 days
          after the Maturity Date of the  Debentures  (except for the payment of
          principal  on Qualified  Indebtedness  to the extent  permitted  under
          Section  25(e)(ii)),  (C)  Indebtedness  represented by trade payables
          incurred  by the  Company  in the  ordinary  course of  business,  (D)
          Indebtedness   incurred  in  connection  with  a  Qualified  Inventory
          Financing,  provided  that the  proceeds of such  Qualified  Inventory
          Financing  are  applied  to  make  cash  collateral  payments  on  the
          Debentures in the manner provided in Section  25(g)(i)(F)  hereof, (E)
          Indebtedness   incurred  in  connection  with  a  Qualified   Mortgage
          Financing,  provided  that the  proceeds  of such  Qualified  Mortgage
          Financing  are  applied  to  make  cash  collateral  payments  on  the
          Debentures in the manner provided in Section  25(g)(i)(G)  hereof, (F)
          Indebtedness  that is not  secured  by any assets or  property  of the
          Company or any of its Subsidiaries,  is made expressly  subordinate in
          right of payment to the  Debentures  and that does not  provide at any
          time for the payment of any  principal  thereon until at least 91 days
          after   the   Maturity   Date   of   the   Debentures   ("Subordinated
          Indebtedness")  pursuant to a subordination  agreement  containing the
          provisions  attached hereto as Exhibit A executed and delivered by the
          Company and any holder of Subordinated  Indebtedness to each holder of
          Debentures as a condition to the incurrence of such Indebtedness,  (G)
          Indebtedness  incurred,  assumed or guaranteed in connection  with the
          Interferon Acquisition, and (H) Indebtedness relating to the Company's
          Series A and/or B 7% Senior  Secured  Convertible  Debentures Due June
          30,  2007.   Notwithstanding  anything  herein  to  the  contrary,  no
          Qualified  Indebtedness  may be incurred  (but  excluding  Acquisition
          Indebtedness)  unless  as  a  condition  to  the  incurrence  of  such
          Indebtedness,  the Company shall have made cash collateral payments in
          an aggregate amount of Outstanding  Principal Amount of all Debentures
          as of the date of the incurrence of such  Indebtedness (pro rata among
          all holders of Debentures) in accordance with Section 25(g)(ii) hereof
          equal  to  fifty  percent  (50%)  of  the  principal   amount  of  the
          Indebtedness  so incurred or an amount as  otherwise  required by this
          Section  25 (or if  such  amount  exceeds  the  remaining  Outstanding
          Principal  Amount  on all  outstanding  Debentures  together  with the
          accrued  and  unpaid  interest  thereon,  then an amount  equal to the
          remaining Outstanding  Principal Amount on all outstanding  Debentures
          together with the accrued and unpaid  interest  thereon).  The Company
          shall  file with the SEC on Form 8-K true and  complete  copies of the
          financial  statements  of an Acquired  Business for which the purchase
          price  is paid or  payable  in cash  and/or  cash  equivalents  and/or
          Indebtedness   indicating  thereon,  among  other  things,  the  items
          comprising the EBITDA of the Acquired  Business and  contemporaneously
          therewith,  but in no event  prior to the  filing  of such  Form  8-K,
          deliver  a copy  of  such  financial  statements  to  each  holder  of
          Debentures;   provided,  however,  that,  notwithstanding  anything
          herein  to  the  contrary,  if  the  Company  does  not  file with the
          SEC  financial  statements  of any  Acquired  Business  for  which the
          purchase  price is paid or payable  in cash  and/or  cash  equivalents
          and/or  Indebtedness in the time and manner provided herein,  then the
          Acquisition  Multiple with respect to such Acquired  Business shall be
          deemed zero (0) and the Company  shall not be entitled to acquire such
          Acquired  Business  unless as a condition  thereto,  the Company shall
          have  contemporaneously  with the closing of the  acquisition  of such
          Acquired  Business made a cash  collateral  payment on the Outstanding
          Principal  Amount of the Debentures then  outstanding  (pro rata among
          all holders of Debentures) in an amount equal to 100% of the aggregate
          cash,  cash  equivalents  and  Acquisition  Indebtedness  incurred  in
          connection  with  the   acquisition  of  such  Acquired   Business  in
          accordance with Section 25(g)(ii) hereunder (or if such amount exceeds
          the  remaining   Outstanding   Principal  Amount  on  all  outstanding
          Debentures together with the accrued and unpaid interest thereon, then
          an amount equal to the remaining  Outstanding  Principal Amount on all
          outstanding  Debentures  together with the accrued and unpaid interest
          thereon).

     ii.  Notwithstanding  the  foregoing,  so long as any of the Debentures are
          outstanding  and cash  collateral  payments  have not been  made in an
          amount equal to the entire  Outstanding  Principal  Amount and accrued
          and unpaid  interest on all Debentures  pursuant to Section 25(g),  no
          Pari Passu Indebtedness or Subordinated  Indebtedness may be incurred,
          directly or indirectly,  by the Company or any of its  Subsidiaries if
          during the period  commencing on the tenth (10th)  Business Day (or in
          the case of clause (ii) of the definition of Pari Passu  Indebtedness,
          the  twentieth   (20th)  Business  Day)   immediately   preceding  the
          incurrence  of  any  such  Pari  Passu  Indebtedness  or  Subordinated
          Indebtedness  and ending on and  including  the date on which any such
          Pari Passu  Indebtedness or Subordinated  Indebtedness is incurred (A)
          an event  constituting  an Event of  Default or an event that with the
          passage of time and without  being cured would  constitute an Event of
          Default,  has  occurred  and  is  continuing,   (B)  any  Registration
          Statement   that  is  required  to  be   effective   pursuant  to  the
          Registration  Rights  Agreement is not effective and available for the
          sale of at least all of the Registrable  Securities (as defined in the
          Registration  Rights  Agreement)  required  to  be  included  in  such
          Registration  Statement  pursuant  to the  terms  of the  Registration
          Rights  Agreement or (C) there has been any Grace Period (as such term
          is defined in the Registration Rights Agreement).

     iii. If at any time when any of the  Debentures  are  outstanding  and cash
          collateral payments shall not have been made in an amount equal to the
          entire Outstanding  Principal Amount of the Debentures,  together with
          accrued interest thereon,  in accordance with Section  25(g)(ii),  the
          Company  shall  purchase  any Acquired  Business,  whether in one or a
          series  of  transactions,  for an amount  of  aggregate  consideration
          (whenever  paid in the form of cash,  cash  equivalents or Acquisition
          Indebtedness) that exceeds the Acquisition  Multiple for such Acquired
          Business,   (such  excess  amount,  the  "Excess  Permitted  Aggregate
          Consideration"),  the Company shall,  simultaneous with the closing of
          the purchase of the Acquired Business,  make cash collateral  payments
          in  respect  of an  aggregate  Outstanding  Principal  Amount  of  the
          Debentures  (pro rata among all holders of  Debentures)  in accordance
          with Section  25(g)(ii)  hereof equal to one hundred percent (100%) of
          the  Excess  Permitted  Aggregate  Consideration  (or if  such  amount
          exceeds the remaining  Outstanding Principal Amount on all outstanding
          Debentures together with the accrued and unpaid interest thereon, then
          an amount equal to the remaining  Outstanding  Principal Amount on all
          outstanding  Debentures  together with the accrued and unpaid interest
          thereon).

(c) Restricted  Payments.  Notwithstanding  anything herein to the contrary,  so
long as any of the Debentures are outstanding and cash collateral  payments have
not been made in an amount equal to the entire Outstanding  Principal Amount and
accrued and unpaid  interest on all Debentures  pursuant to Section  25(g),  the
Company shall not, and the Company shall not permit any of its  Subsidiaries to,
directly or indirectly redeem, defease,  repurchase,  repay or make any payments
in respect  of, by the  payment  of cash or  marketable  securities,  including,
without  limitation,  Common Stock (in whole or in part,  whether by way of open
market purchases,  tender offers, private transactions or otherwise), all or any
portion of any Pari Passu Indebtedness,  Qualified Mortgage Financing, Qualified
Inventory  Financing or  Subordinated  Indebtedness of the Company or any of its
Subsidiaries,  whether by way of payment in respect of principal of (or premium,
if any) or  interest  on,  such  Pari  Passu  Indebtedness,  Qualified  Mortgage
Financing,   Qualified  Inventory  Financing  or  Subordinated  Indebtedness  or
otherwise;  provided,  however, that, so long as no event constituting,  or that
with the passage of time and without being cured would  constitute,  an Event of
Default  has  occurred  and is  continuing,  on the  date  any of the  following
payments is due or is otherwise  made and subject to the terms and conditions of
any subordination  agreement entered into in connection with the issuance of any
Subordinated Indebtedness as provided herein, the Company may, without regard to
the foregoing  limitation:  (i) pay in cash scheduled interest payments, in each
case in the manner set forth in the original  documentation  governing such Pari
Passu Indebtedness,  Qualified Mortgage Financing, Qualified Inventory Financing
or Subordinated Indebtedness, at an annual rate not to exceed (A) 10% per annum,
if such interest rate is fixed,  or (B) the prime rate plus two percent (2%), if
such  interest  rate is  floating,  of such Pari Passu  Indebtedness,  Qualified
Mortgage Financing,  Qualified Inventory Financing or Subordinated Indebtedness,
and (ii) make any principal  payments when due on any Qualified  Indebtedness at
any time  prior to the  two-year  anniversary  of the  Original  Issuance  Date;
provided,  however,  that the Company may not make any such  principal  payments
unless as a condition to each time any such Qualified  Indebtedness is incurred,
other  than  Acquisition  Indebtedness,   (including  each  time  any  Qualified
Indebtedness is incurred under a revolving  credit  facility or otherwise),  the
Company  shall have made cash  collateral  payments  in an  aggregate  amount of
Outstanding Principal Amount of all Debentures then outstanding at the time such
Qualified  Indebtedness  was incurred (pro rata among all holders of Debentures)
in accordance with Section  25(g)(ii) hereof equal to fifty percent (50%) of the
principal amount of the Qualified  Indebtedness so incurred, it being understood
and agreed that,  for the  avoidance of doubt,  if the Company has not satisfied
its cash collateral  payment  obligations  under Section 25(g)(ii) in connection
with the incurrence of any such Qualified Indebtedness, the Company may not make
any of the principal payments otherwise permitted under this subsection (ii).

(d)  Restrictions on Liens. So long as any of the Debentures are outstanding and
cash  collateral  payments  have not been made in an amount  equal to the entire
Outstanding  Principal  Amount and accrued and unpaid interest on all Debentures
pursuant to Section 25(g), the Company shall not create, incur, assume or suffer
to exist, or permit any of its Subsidiaries to create,  incur,  assume or suffer
to exist,  any Lien upon or with  respect  to any of its  assets or  properties,
whether  now owned or  hereafter  acquired;  file or  suffer to exist  under the
Uniform  Commercial  Code or any similar law or statute of any  jurisdiction,  a
financing  statement  (or the  equivalent  thereof)  that names it or any of its
Subsidiaries  as  debtor;  sign  or  suffer  to  exist  any  security  agreement
authorizing  any secured party  thereunder to file such financing  statement (or
the  equivalent  thereof);  sell any of its  property  or assets  subject  to an
understanding or agreement, contingent or otherwise, to repurchase such property
or assets (including sales of accounts receivable) with recourse to it or any of
its  Subsidiaries  or  assign  or  otherwise  transfer,  or  permit  any  of its
Subsidiaries  to assign or  otherwise  transfer,  any  account or other right to
receive income; other than, as to all of the above, Permitted Liens;

(e)      Restricted Investments.
         ----------------------

(xxxii)  Except as provided in Section 4(v) of the Securities Purchase Agreement
         and  except  for  cash  held by the  Company's  Belgian  Subsidiary  in
         connection  with  the  Belgian  Contribution,  so  long  as  any of the
         Debentures are outstanding  and cash collateral  payments have not been
         made in an amount equal to the entire Outstanding  Principal Amount and
         accrued  and unpaid  interest  on all  Debentures  pursuant  to Section
         25(g),  the  Company  shall  not  and  shall  not  permit  any  of  its
         Subsidiaries  to,  directly  or  indirectly,  deposit or hold any cash,
         securities, certificates of deposit, investments or other funds or cash
         equivalent  in any  account  for which the  Agent has not  executed  an
         account  control  agreement  and  obtained a perfected  first  priority
         security interest thereover.

(xxxiii) So long as any of the Debentures are  outstanding  and cash  collateral
         payments  have  not  been  made  in  an  amount  equal  to  the  entire
         Outstanding  Principal  Amount and accrued  and unpaid  interest on all
         Debentures  pursuant to Section 25(g), the Company shall not,  directly
         or  indirectly,  make or  commit  or agree to make any  loan,  advance,
         guarantee  of  obligations,   other  extension  of  credit  or  capital
         contributions  to,  or hold or  invest in or commit or agree to hold or
         invest  in, or  purchase  or  otherwise  acquire  or commit or agree to
         purchase or otherwise  acquire any shares of the capital stock,  bonds,
         notes, debentures or other securities of, or make or commit or agree to
         make any other  investment  in, any other  Person  (including,  without
         limitation,  a Subsidiary),  or purchase or own any futures contract or
         otherwise  become  liable for the purchase or sale of currency or other
         commodities  at a future date in the nature of a futures  contract,  or
         otherwise   transfer  any  cash,   property  or  other  assets  to  any
         Subsidiary,  or  permit  any  of  its  Subsidiaries  to do  any  of the
         foregoing,   other  than  in   connection   with  (i)  the   Interferon
         Acquisition,  (ii) an  acquisition  of, or investment in, the assets or
         capital  stock  of  any  other  Person  by  the  Company  or any of its
         Subsidiaries for  consideration  consisting  solely of shares of Common
         Stock that are not subject to any repurchase,  retirement or redemption
         obligation  of  the  Company  or  any of  its  Subsidiaries  (a  "Stock
         Acquisition")  and (iii) the contribution by the Company to its Belgian
         Subsidiary of not more than $25,000 in the aggregate for the payment of
         ordinary course business expenses (the "Belgian Contribution").

(f) Restrictions on Asset Sales and Purchases.  So long as any of the Debentures
are  outstanding  and cash  collateral  payments have not been made in an amount
equal to the entire Outstanding Principal Amount and accrued and unpaid interest
on all Debentures pursuant to Section 25(g), the Company shall not and shall not
permit any of its Subsidiaries to convey,  sell, lease or sublease,  transfer or
otherwise  dispose  of,  whether  in one  transaction  or a  series  of  related
transactions,  all or any part of its business,  property or assets, whether now
owned or hereafter  acquired (or agree to do any of the foregoing),  other than,
so long as no event  constituting  an Event of Default or an event that with the
passage of time and without  being cured would  constitute  an Event of Default,
has  occurred  and is  continuing  at the  time  of  such  sale,  (i)  sales  of
Intellectual  Property,  (ii)  sales of  Inventory  in the  ordinary  course  of
business (iii) or as otherwise expressly permitted under this Debenture. So long
as any of the Debentures are outstanding  and cash collateral  payments have not
been made in an amount  equal to the  entire  Outstanding  Principal  Amount and
accrued and unpaid  interest on all Debentures  pursuant to Section  25(g),  the
Company  shall not and shall not permit any of its  Subsidiaries  to purchase or
otherwise   acquire,   whether  in  one  transaction  or  a  series  of  related
transactions,  all or  substantially  all of the  assets of any  Person  (or any
division thereof), other than in connection with (A) the Interferon Acquisition,
(B)  the  incurrence  of  Acquisition   Indebtedness  to  the  extent  permitted
hereunder,  (C)  a  Qualified  Inventory  Financing,  (D) a  Qualified  Mortgage
Financing or (E) a Stock Acquisition.

(g)                   Cash Collateral.
                      ---------------

i.       Unless  and  until  such  time as the  Company  shall  have  made  cash
         collateral  payments  in respect of the  entire  Outstanding  Principal
         Amount of this  Debenture,  together  with accrued and unpaid  interest
         thereon,  the Company shall make cash collateral payments in accordance
         with this  Section  25(g) in respect  of a portion  of the  Outstanding
         Principal  Amount of this  Debenture,  together with accrued and unpaid
         interest  thereon,  in cash and/or Common Stock (as provided in Section
         25(g)(ii) and (iii)) as follows:

     (A) on each Biweekly  Revenue Cash Collateral  Date, the Company shall make
cash collateral  payments in respect of the Outstanding  Principal Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
product derived by multiplying (i) .5 by (ii) the Company Consolidated  Revenues
for the period  commencing  on the date of the  immediately  preceding  Biweekly
Revenue Cash Collateral Date (or the Original  Issuance Date, in the case of the
first  Biweekly   Revenue  Cash  Collateral   Date)  through  the  Business  Day
immediately preceding the applicable Biweekly Revenue Cash Collateral Date;

     (B) on each Monthly  Revenue Cash  Collateral  Date, the Company shall make
cash collateral  payments in respect of the Outstanding  Principal Amount of all
Debentures,  together with accrued interest  thereon,  in an amount equal to the
greater of (i) the product  derived by multiplying  (a) .1 by (b) the portion of
the  Outstanding  Principal  Amount of all  Debentures  and  accrued  and unpaid
interest  thereon for which cash  collateral  payments  have not been made under
Section 25(g) as of March 31, 2004 and (ii) the product  derived by  multiplying
(a) .5 by (b) the Company Consolidated Revenues for the period commencing on the
date of the immediately preceding Monthly Revenue Cash Collateral Date (or April
1, 2004, in the case of the first Monthly Revenue Cash Collateral  Date) through
the Business Day  immediately  preceding  the  applicable  Monthly  Revenue Cash
Collateral Date;

     (C) on the First Revenue  Milestone Cash Collateral Date, the Company shall
make cash collateral payments in respect of the Outstanding  Principal Amount of
all Debentures,  together with accrued interest  thereon,  in an amount equal to
the sum of (i) $400,000 and (ii) the product  derived by  multiplying  (X) .8 by
(Y) the amount,  if any, by which the Company  Consolidated  Revenues during the
First Revenue  Milestone  Measuring  Period exceeds the First Revenue  Milestone
Target;

     (D) on the Second Revenue Milestone Cash Collateral Date, the Company shall
make cash collateral payments in respect of the Outstanding  Principal Amount of
all Debentures,  together with accrued interest  thereon,  in an amount equal to
the excess,  if any, of (i) the sum of (a) $750,000 and (b) the product  derived
by  multiplying  (X)  .8 by (Y)  the  amount,  if  any,  by  which  the  Company
Consolidated  Revenues  during the Second  Revenue  Milestone  Measuring  Period
exceeds the Second Revenue Milestone Target,  over (ii) the cumulative amount of
cash  collateral  payments  (including  the dollar value  attributed to any such
payments made in the form of Repayment  Shares in accordance with the provisions
of Section  25(g)(iii))  that have been made by the Company  prior to the Second
Revenue  Milestone Cash  Collateral  Date pursuant to Sections  25(g)(i)(A)  and
25(g)(i)(C) hereof;

     (E) on the Third Revenue  Milestone Cash Collateral Date, the Company shall
make cash collateral payments in respect of the Outstanding  Principal Amount of
all Debentures,  together with accrued interest  thereon,  in an amount equal to
the excess, if any, of (i) the sum of (a) $1,500,000 and (b) the product derived
by  multiplying  (X)  .8 by (Y)  the  amount,  if  any,  by  which  the  Company
Consolidated  Revenues  during  the Third  Revenue  Milestone  Measuring  Period
exceeds the Third Revenue Milestone  Target,  over (ii) the cumulative amount of
cash  collateral  payments  (including  the dollar value  attributed to any such
payments made in the form of Repayment  Shares in accordance with the provisions
of Section  25(g)(iii))  that have been made by the  Company  prior to the Third
Revenue  Milestone  Cash  Collateral  Date  pursuant  to  Sections  25(g)(i)(A),
25(g)(i)(C) and 25(g)(i)(D) hereof;

     (F) on the Qualified  Inventory  Financing Date,  subject to Section 28(d),
the Company shall make cash  collateral  payments in respect of the  Outstanding
Principal Amount of all Debentures,  together with accrued interest thereon,  in
an amount an amount equal to $2,000,000.00; and

     (G) on the Qualified Mortgage Financing Date, subject to Section 28(c), the
Company  shall make cash  collateral  payments  in  respect  of the  Outstanding
Principal Amount of all Debentures,  together with accrued interest thereon,  in
an amount equal to $1,500,000.00.

     ii.  On each Cash Collateral Date (and any date for which a cash collateral
          payment  is  required  under  this  Section  25),  the  Company  shall
          irrevocably  deposit,  or cause to be  irrevocably  deposited into the
          Cash  Collateral  Account,   the  portion  of  the  total  Outstanding
          Principal  Amount of all  Debentures  and accrued and unpaid  interest
          thereon for which cash collateral  payments are required to be made in
          accordance with Section 25(g)(i) (or any other provision of Section 25
          requiring cash collateral payments), subject to Section 25(g)(iii), in
          cash in U.S.  Dollars to secure payment of the principal of,  premium,
          if  any,  penalties,  if  any,  and  interest  due on the  outstanding
          Debentures,  pursuant to the Account Control  Agreement and such other
          written agreements and other arrangements  satisfactory to the holders
          of 60% of the Outstanding Principal Amount of all Debentures issued on
          the Original Issuance Date then outstanding,  which shall, among other
          things,  confirm  that the  funds  deposited  in the  Cash  Collateral
          Account  and the  proceeds  of any  letter of credit  issued  shall be
          subject to a perfected  first priority  security  interest in favor of
          the Agent for the benefit of the holders of Debentures.

     iii. Notwithstanding  anything in Section 25(g)(ii) hereof,  but subject to
          Sections 11 and 26 hereof,  (A) on each Cash  Collateral Date relating
          to a cash collateral  payment under Section  25(g)(i)(A),  the Company
          shall  make a payment  by way of  delivery  of 25,000  fully  paid and
          nonassessable  shares of Common Stock (as  equitably  adjusted for any
          stock dividend,  stock split or other similar transaction and pro rata
          among all holders of Debentures)  and (B) on each Cash Collateral Date
          relating to a cash collateral payment under Section  25(g)(i)(B),  the
          Company  shall make a payment by way of delivery of 50,000  fully paid
          and  nonassessable  shares of Common Stock (as equitably  adjusted for
          any stock dividend,  stock split or other similar  transaction and pro
          rata among all holders of  Debentures),  in each case delivered to the
          holder in lieu of cash for such amount (it being understood and agreed
          that (x) the remaining balance of such payments, if any, shall be paid
          in  cash  in  accordance   with  Section   25(g)(ii)   above  and  (y)
          irrespective  of  whether  the value of the  shares  of  Common  Stock
          payable  under clauses (A) or (B) of this Section  25(g)(iii)  exceeds
          the  amount  otherwise  due  under  Section   25(g)(i)(A)  or  Section
          25(g)(i)(B), as applicable, the Company shall issue the full amount of
          the 25,000 or 50,000 shares of Common  Stock,  as  applicable,  on the
          applicable Cash Collateral Date and the value of the additional shares
          of Common  Stock,  if any,  delivered  to the holder  that  exceed the
          amount  required to be paid under the  applicable  subsection  of this
          Section  25(g)  shall be deemed to be a permitted  prepayment  of this
          Debenture   as  provided  in  the  final   sentence  of  this  Section
          25(g)(iii)) represented by duly executed stock certificates registered
          in the name of the holder or its  designee  (the  "Repayment  Shares")
          (or,  in the case of a  public  resale  of such  Repayment  Shares  in
          accordance  with the  provisions  of the  Irrevocable  Transfer  Agent
          Instructions,  provided the Transfer Agent is participating in The DTC
          Fast Automated  Securities  Transfer  Program and, if required by DTC,
          the holder provides a customary representation letter to DTC, upon the
          request  of the  holder,  credit  such  aggregate  number of shares of
          Common  Stock to which the holder  shall be entitled  to the  holder's
          designee's  balance  account  with DTC through its Deposit  Withdrawal
          Agent  Commission  system) with each Repayment  Share being ascribed a
          valued for  purposes of this Section  25(g)(iii)  equal to the product
          derived  by  multiplying  (A) .825 by (B) the  arithmetic  average  of
          Weighted  Average  Prices of the Common Stock on the five  consecutive
          Business  Days ending on and  including  the Business Day  immediately
          preceding the applicable Cash Collateral Date (the "Equity  Collateral
          Conversion  Rate")  provided,  however,  that (x) in no event  may the
          Company pay any portion of a cash -------- -------  collateral payment
          obligation in Repayment Shares if a Registration Statement is not then
          effective and available for the resale of all of the Repayment  Shares
          on the applicable Cash Collateral Date or each date which is within 10
          Business  Days prior to such Cash  Collateral  Date, in which case the
          full  amount  of  such  payments  shall  instead  be  made  in cash in
          accordance  with  Section  25(g)(ii)  and (y) in the event the Company
          does not have a  sufficient  number of Repayment  Shares  reserved and
          available  for  issuance  pursuant  to this  Section  25(g)(iii),  the
          Company  shall issue the maximum  number of Repayment  Shares that are
          available for issuance, pro rata among all holders of Debentures,  and
          the  balance  of  such  payment  shall  instead  be  made  in  cash in
          accordance with Section  25(g)(ii)  hereof.  Cash collateral  payments
          validly  made in the  form of  Repayment  Shares  under  this  Section
          25(g)(iii)  shall be deemed  prepayments  of (i)  first,  accrued  and
          unpaid interest on the Outstanding  Principal Amount of this Debenture
          and (ii) second, Outstanding Principal Amount of this Debenture.

     iv.  The Company  covenants and agrees that it shall make all calculations,
          including,   without   limitation,   all   calculations   of   Company
          Consolidated  Revenues,  necessary to determine the amounts to be paid
          from time to time under this Section 25(g) in strict  accordance  with
          the terms of this Agreement.  The Company further covenants and agrees
          that it shall prepare and publish its  quarterly  and annual  earnings
          releases  and  quarterly  and annual  reports  filed with the SEC with
          sufficient  detail so that the holder of this Debenture  shall be able
          to determine and verify solely from the information  contained therein
          the amount of Company Consolidated  Revenues used to calculate amounts
          to be paid from time to time under this Section 25(g) and to reconcile
          the amount of Company Consolidated  Revenues with the amounts actually
          paid under this Section  25(g).  If any holder of Debentures  disputes
          any  calculations  of Company  Consolidated  Revenues  set forth in or
          omitted  from any public  release or SEC filing that covers any period
          relevant for the  determinations  required  under this Section  25(g),
          such holder shall  deliver  written  notice to the Company  within ten
          Business  Days of the  publication  of  such  release  or SEC  filing,
          describing  in  reasonable  detail the basis for such dispute (and the
          Company shall promptly  deliver such notice to all other holders).  If
          the Company and the disputing  holder(s) of  Debentures  are unable to
          resolve any such  dispute  within two Business  Days of the  Company's
          receipt of notice  thereof,  the Company shall within two (2) Business
          Days submit the disputed matters to the Company's independent, outside
          accountant.  The  Company  shall cause the  accountant  to perform the
          determinations  or calculations and notify the Company and the holders
          of the results no later than ten (10)  Business  Days from the time it
          receives   the   disputed   determinations   or   calculations.   Such
          accountant's determination,  as the case may be, shall be binding upon
          all parties absent manifest  error.  The Company shall bear all costs,
          fees  and  expenses  of  the   accountant   in   rendering   any  such
          determinations.

     v.   On each Cash  Collateral  Date,  the Company  covenants  and agrees to
          execute and deliver a completed Cash Collateral Accounting Certificate
          in the  form  attached  hereto  as  Exhibit  C (the  "Cash  Collateral
          Certificate")  by  facsimile  and  first  class  mail  to  the  Person
          designated on the form of Cash  Collateral  Certificate (or such other
          Person  or  Persons  as the  holders  of not less than 60% of the then
          Outstanding Principal Amount of Debentures may designate in writing to
          the Company), which shall be certified to each holder of Debentures as
          true and  correct by the Chief  Executive  Officer or Chief  Financial
          Officer of the Company. THE COMPANY ACKNOWLEDGES AND AGREES THAT IN NO
          EVENT SHALL IT OR ANY PERSON ON THE COMPANY'S  BEHALF DELIVER ANY CASH
          COLLATERAL CERTIFICATE TO ANY HOLDER OF DEBENTURES WITHOUT THE EXPRESS
          PRIOR WRITTEN CONSENT OF SUCH HOLDER.

     vi.  All payments by the Company pursuant to this Section 25(g), whether in
          the form of cash or Repayment Shares, shall be made pro rata among all
          Debentures.

     vii. Notwithstanding anything herein to the contrary, the Company shall not
          be  obligated  to make any  collateral  payments,  or deliver any Cash
          Collateral  Certificates,  pursuant to this Section 25(g)  (whether in
          cash or in shares  of  Common  Stock)  on any  Biweekly  Revenue  Cash
          Collateral  Date,  Monthly  Revenue Cash  Collateral  Date,  the First
          Revenue  Milestone Cash Collateral Date, the Second Revenue  Milestone
          Cash Collateral  Date, or the Third Revenue  Milestone Cash Collateral
          Date to the extent that the balance in the Cash Collateral Account (as
          defined  in  the  Securities  Purchase  Agreement)  is not  less  than
          $1,300,000.

     (viii)  the  Holder  agrees  that,   in  the  event  of  any   unauthorized
          distributions (as defined below) from the Cash Collateral Account, the
          principal  amounts of the Debentures  will be reduced by the amount of
          such unauthorized  distributions;  the allocation of such reduction to
          the PL Debentures to be made pro rata.  An  unauthorized  distribution
          would  be any  distribution  other  than  as  permitted  under  the PL
          Debentures or the related agreements.



(h)  Conflicts.  In the event there is any  conflict  among  provisions  of this
Section 25 as to the amount of any cash collateral  payment  required to be paid
by the Company into the Cash  Collateral  Account,  the provision  requiring the
Company to pay the greater amount shall in all instances control.

26.  Limitation  on Number of  Conversion  Shares.  The Company (1) shall not be
obligated to issue  Conversion  Shares upon  conversion of this  Debenture,  (2)
shall not be permitted  to issue  Interest  Shares (but instead  shall make Cash
Interest  Payments),  (3) shall not be permitted to issue Repayment  Shares (but
instead shall make cash collateral payments in cash), (4) shall not be permitted
to make a Company Conversion, and (5) shall not be permitted to issue conversion
shares, interest shares,  repayment shares, or warrant shares in connection with
the  Previously-Issued   Securities  (as  defined  in  the  Securities  Purchase
Agreement),  in each case to the  extent  that the  issuance  of such  shares of
Common  Stock  would cause the Company to exceed that number of shares of Common
Stock  which the Company may issue under this  Debenture  (the  "Exchange  Cap")
without  breaching the Company's  obligations  under the rules or regulations of
the Principal  Market,  except that such limitation shall not apply in the event
that the Company  obtains the  approval of its  stockholders  as required by the
Principal  Market (or any successor rule or regulation)  for issuances of Common
Stock in excess of such amount.  Until such approval is obtained,  the holder of
this  Debenture  shall not be issued,  upon  conversion or redemption  of, or as
interest under, this Debenture, shares of Common Stock in an amount greater than
the difference between (i) the product of (x) the Exchange Cap amount multiplied
by (y) a fraction,  the numerator of which is the aggregate  principal amount of
Debentures issued to such Holder pursuant to the Securities  Purchase  Agreement
and the  denominator  of  which is the  aggregate  principal  amount  of all the
Debentures issued to all Debenture  holders pursuant to the Securities  Purchase
Agreement  and (ii) the sum of (A) the aggregate  number of Interest  Shares and
Repayment  Shares  and shares  issued in  connection  with a Company  Conversion
issued to the holder of this Debenture (and all  predecessor  holders) as of the
date of such conversion plus (B) the aggregate  number of shares of Common Stock
issued to the holder of this  Debenture (and all  predecessor  holders) upon the
exercise of any Warrants held by such holder (and all predecessor holders) as of
the date of such  conversion  plus (C) the aggregate  number of shares of Common
Stock  issued to the  holder of this  Debenture  (and all  predecessor  holders)
pursuant  to  the  Previously-Issued   Securities  (such  difference,  the  "Cap
Allocation  Amount").  If at any time when the Holder shall deliver a Conversion
Notice pursuant to Section 4 hereof the Company shall be prohibited  pursuant to
the  provisions  of this  Section  26 from  issuing  all or any  portion  of the
Conversion Shares issuable pursuant to such Conversion Notice,  then the Company
shall pay in immediately  available funds to the holder of this Debenture within
two (2)  Business  Days of the date of delivery of such  Conversion  Notice,  an
amount in cash equal to the product of (X) the number of shares of Common  Stock
which could not be issued by virtue of the limitations contained in this Section
26  multiplied  by (Y) the average of the Weighted  Average  Price of the Common
Stock on each of the five (5)  trading  days  ending  on the third  trading  day
immediately  preceding the date the date of delivery of such Conversion  Notice.
The Outstanding Principal Amount of this Debenture shall be reduced by an amount
equal to the Outstanding  Principal  Amount of this Debenture  designated in the
Conversion  Notice that could not be converted by virtue of the  limitations set
forth in this Section 26 and for which the Company has made payment  pursuant to
the immediately preceding sentence.

27.      Taxes.
         -----

(a) The Company shall pay any and all documentary,  stamp, transfer (but only in
respect of the  registered  holder  thereof) and other similar taxes that may be
payable  with  respect to the  issuance  and  delivery of Common  Stock upon the
conversion  of  Debentures;  provided,  however,  that the Company  shall not be
required to pay any tax that may be payable in respect of any transfer  involved
in the issue or delivery of Common  Stock or other  securities  or property in a
name other than that of the registered  holder of this Debenture to be converted
and such holder shall pay such amount, if any, to cover any applicable  transfer
or similar tax.

(b) The Company  shall be  permitted to withhold  from any amounts  payable to a
Debenture  holder or a holder of Common  Stock any taxes  required  by law to be
withheld  from such  amount.  If the  Company  shall be  required to withhold or
deduct any tax,  levy or other  governmental  charge,  excluding  (A) net income
taxes,  franchise  taxes,  or taxes  imposed  on or  measured  by net income (or
overall  gross  receipts,  to the extent such tax is imposed in lieu of a tax on
net income by a  jurisdiction  that does not impose any tax based on or measured
by net  income)  on any  Debenture  holder  by the  jurisdiction  in which  such
Debenture holder is organized or any other  jurisdiction in which such Debenture
holder would be subject to tax without regard to the  transactions  contemplated
hereby  and (B)  U.S.  Federal  withholding  taxes  (unless  such  U.S.  Federal
withholding  taxes would not be imposed but for a change in or  amendment to the
Internal Revenue Code of 1986, as amended (the "Code"), the Treasury Regulations
or any  other  administrative  authority  thereunder  or any tax  treaty  or the
release or promulgation of any judicial decision relating thereto, in each case,
on or after the date such Debenture holder acquires a Debenture (each, a "Change
in Law")) (all such non-excluded  taxes,  levies or other governmental  charges,
"Taxes") from any payment of interest, or any accrual of original issue discount
(if  applicable),  for U.S.  Federal income tax purposes made hereunder or under
any Debenture to or for the benefit of any Debenture holder, then (A) the amount
payable  shall be  increased  by the amount  necessary  so that after making all
required deductions and withholdings (including deductions and withholdings with
respect to additional  amounts  payable under this Section 27(b)) such Debenture
holder shall  receive an amount equal to the amount it would have received if no
such deduction or withholding of Taxes had been required,  (B) the Company shall
make such deduction or withholding and (C) the Company shall pay the full amount
deducted to the appropriate governmental authority in accordance with applicable
law. If any Debenture holder is organized under the laws of a jurisdiction other
than the United  States,  any State thereof or the District of Columbia  (each a
"Non-U.S.  Debenture  Holder"),  it shall  deliver to the  Company two copies of
either  (A)  U.S.  Internal  Revenue  Service  Form  W-8BEN  (claiming  complete
exemption from U.S. Federal  withholding tax under an income tax treaty), or any
successor form; (B) U.S. Internal Revenue Service Form W-8ECI (claiming complete
exemption from U.S.  Federal  withholding  tax because the income is effectively
connected with a U.S. trade or business), or any successor form; (C) in the case
of a Non-U.S.  Debenture Holder claiming exemption from U.S. Federal withholding
tax under  Section  871(h) or 881(c) of the Code,  with  respect to  payments of
"portfolio  interest," U.S. Internal Revenue Service Form W-8BEN  (certifying as
to beneficial  ownership),  or any successor form, and a certificate in form and
substance  reasonably  acceptable to the Company representing that such Non-U.S.
Debenture  Holder is not a "bank" for purposes of Section 881(c) of the Code, is
not a 10-percent  shareholder (within the meaning of Section 871(h)(3)(B) of the
Code) of the Company and is not a "controlled  foreign  corporation"  related to
the Company (within the meaning of Section  864(d)(4) of the Code); or (D) other
applicable form, certificate or document prescribed by the U.S. Internal Revenue
Service  certifying  as to such Non-U.S.  Debenture  Holder's  entitlement  to a
complete  exemption from U.S.  Federal  withholding  tax, as applicable,  in all
cases such forms and other documents being properly  completed and duly executed
by such Non-U.S.  Debenture Holder claiming complete exemption from U.S. Federal
withholding  tax on payments of interest  (or of  original  issue  discount,  if
applicable)  for U.S.  Federal  income tax  purposes  by the  Company  under the
Debentures.  Each  Debenture  holder  and each  holder of common  stock  that is
organized  under the laws of a jurisdiction  other than the United  States,  any
State thereof or the District of Columbia (each a "Non-U.S. Equity Holder") also
shall deliver to the Company,  to the extent legally able to do so, with respect
to payments of dividends for U.S. Federal income tax purposes by the Company, if
applicable,  two copies of either (A) U.S.  Internal Revenue Service Form W-8BEN
(claiming a reduction of U.S. Federal withholding tax under an applicable income
tax treaty,  if any), or any successor form, (B) U.S.  Internal  Revenue Service
Form W-8ECI  (claiming  complete  exemption from U.S.  Federal  withholding  tax
because the income is effectively  connected with a U.S. trade or business),  or
any  successor  form,  or (C) other  applicable  form,  certificate  or document
prescribed by the U.S.  Internal Revenue Service  certifying as to such Non-U.S.
Equity  Holder's  entitlement  to an  exemption  from,  or a reduction  of, U.S.
Federal  withholding  tax on payments of dividends for U.S.  Federal  income tax
purposes  by the  Company,  as  applicable,  in all cases  such  forms and other
documents  being  properly  completed and duly executed by such Non-U.S.  Equity
Holder. In addition,  each Debenture holder and each holder of Common Stock that
is not otherwise exempt from "back-up  withholding" shall deliver to the Company
two properly  completed  and duly  executed  copies of either (A) U.S.  Internal
Revenue Service Form W-8BEN,  or any successor form, (B) U.S.  Internal  Revenue
Service Form W-8ECI,  or any successor form, (C) U.S.  Internal  Revenue Service
Form W-9, or any successor form, or (D) other  applicable  form,  certificate or
document prescribed by the U.S. Internal Revenue Service, as applicable, in each
case  indicating  that such  Debenture  holder or holder of Common  Stock is not
subject to "back-up withholding" for U.S. Federal income tax purposes. The forms
and other  documents  required to be delivered  pursuant to this  Section  27(b)
shall be delivered  (A) on or prior to the Original  Issuance  Date and (B) from
time to time  thereafter  if within ten (10)  Business  Days after  receipt of a
written request therefor by the Company. In addition,  each Debenture holder and
each  holder of Common  Stock shall  promptly  notify the Company at any time it
determines  that  it is no  longer  in a  position  to  provide  any  previously
delivered (or requested) form, document or certificate to the Company, including
as a result in whole or in part from a Change in Law;  provided,  however,  that
the failure to provide such notice shall not affect any Debenture holder's right
to any additional amounts hereunder.

(c) Notwithstanding anything to the contrary in Section 27(b) above, the Company
shall not be  required  to pay any  additional  amount to any  Debenture  holder
pursuant to the  preceding  paragraph  to the extent the Tax in respect of which
such  additional  amount would  otherwise be payable would not have been imposed
but for the  failure of such  Debenture  holder to comply  with its  obligations
under such  paragraph;  provided,  however,  that the  failure  to  provide  the
applicable form, document or certificate  pursuant to the preceding paragraph as
provided in the notice required by the preceding paragraph resulting in whole or
in part from a Change in Law shall not affect such  Debenture  holder's right to
any additional amounts hereunder.

28.      Security.
         --------

(a) The Debentures shall be secured to the extent and in the manner
provided in the Security Agreement.

(b) The Company  acknowledges and agrees that all amounts  deposited in the Cash
Collateral  Account (a) shall  constitute  Collateral for all obligations of the
Company  under  the  Debentures  (the  "Obligations").  At any time  during  the
continuance  of an Event of Default,  the Agent may require the Cash  Collateral
Account Bank to transfer all amounts held in the Cash Collateral  Account to the
Agent  for  application  to  the  Obligations  pursuant  to  the  terms  of  the
Debentures.

(c) In the event that the Company  desires to enter into the Qualified  Mortgage
Financing, the holder, by its acceptance of this Debenture,  agrees to cause the
Agent to enter into a written agreement,  reasonably  satisfactory to the Agent,
providing that, upon the  consummation of the Qualified  Mortgage  Financing and
the Company making the deposit into the Cash Collateral Account of not less than
$1,500,000 in cash in accordance with Sections  25(g)(i)(G)  and 25(g)(ii),  the
Agent shall release its Lien on the Acquisition  Buildings and shall execute and
deliver to the Company or to the provider of such  financing or the purchaser of
the  Acquisition  Buildings such release or  reconveyance  instruments  and such
other  documents  as shall be  reasonably  necessary  to release the Lien of the
Agent on the Acquisition  Buildings  pursuant to the Mortgages,  in each case at
the  sole  cost  and  expense  of  the  Company  and  without  any  warranty  or
representation by, or recourse to, the Agent or the holder of this Debenture.

(d) In the event that the Company desires to enter into the Qualified  Inventory
Financing, the holder, by its acceptance of this Debenture,  agrees to cause the
Agent to enter into a written agreement,  reasonably  satisfactory to the Agent,
providing that, upon the consummation of the Qualified  Inventory  Financing and
the deposit into the Cash Collateral Account of not less than $2,000,000 in cash
in accordance with Sections  25(g)(i)(F) and 25(g)(ii),  the Agent shall release
its Lien on the Inventory and shall execute and deliver to the Company or to the
provider of such financing such UCC3 Amendments (or  authorizations  to file the
same) and such other  documents as shall be reasonably  necessary to release the
Lien of the Agent on the Inventory pursuant to the Security  Agreement,  in each
case at the sole cost and expense of the  Company  and  without any  warranty or
representation by, or recourse to, the Agent or the holder of this Debenture.

(e) If at any time the Company  shall have  deposited  into the Cash  Collateral
Account an amount equal to the entire  Outstanding  Principal Amount and accrued
and unpaid interest on all Debentures  pursuant to Section 25(g), the holder, by
its  acceptance  of this  Debenture,  agrees to  release,  or cause the Agent to
release, its Lien on all Collateral, other than the Cash Collateral Account, and
shall  execute  and  deliver to the  Company  (or cause the Agent to execute and
deliver to the Company) such release or reconveyance  instruments and such other
documents  as  shall  be  reasonably  necessary  to  release  the  Liens  on the
Collateral  (other  than the Cash  Collateral  Account) in each case at the sole
cost and expense of the Company and without any warranty or  representation  by,
or recourse to, the Agent or the holder of this Debenture.






IN WITNESS  WHEREOF,  the Company has caused this instrument to be duly executed
by an officer thereunto duly authorized.

Dated:  October 6, 2005
                                           HEMISPHERX BIOPHARMA, INC.

                                       By: s/
                                           --------------------
                                           Name:
                                           Title:

                                 Print Address:
                                   Telephone:
                                   Facsimile:

ATTEST
- ------------------------------
Name:
Title:







                                    EXHIBIT I
                      (To be Executed by Registered Holder
                         in order to Convert Debenture)
                                CONVERSION NOTICE
                                       FOR
            7% SENIOR SECURED CONVERTIBLE DEBENTURE DUE JUNE 30, 2007

The undersigned,  as Holder of the 7% Senior Secured  Convertible  Debenture Due
June 30, 2007 of  HEMISPHERX  BIOPHARMA,  INC.  (the  "Company"),  No. _, in the
outstanding  principal  amount of $_______ (the  "Debenture"),  hereby elects to
convert  $_______ of the outstanding  principal amount of the Debenture (as well
as accrued and unpaid  interest)  into shares of Common Stock,  par value $0.001
per share (the "Common  Stock"),  of the Company  according to the conditions of
the Debenture, as of the date written below.

         Date of Conversion:
                            --------------------------------------------------

         Principal Amount of Debentures to be converted:

         Accrued Interest to be converted:
                                          ------------------------------------

         Installment Date to which the amount to be converted relates:

         Tax ID Number (If applicable):
                                        --------------------------------------

Please confirm the following information:

         Conversion Price:
                          ----------------------------------------------------

         Number of shares of Common Stock to be issued:
                                                       -----------------------

         Is the Variable Price being relied on pursuant to Section 6(c) of the
Debenture?  (check one)  YES       No
                            ------    ------





         Please  issue the  Common  Stock into  which the  Debentures  are being
converted  and, if  applicable,  any check drawn on an account of the Company in
the following name and to the following address:

                  Issue to:
                           -----------------------------------------------

2557:

                  Address:
                         -------------------------------------------------

                  Telephone Number:
                                   ---------------------------------------

                  Facsimile Number:
                                   ---------------------------------------

                  Authorization:
                                ------------------------------------------

                  By:
                     -----------------------------------------------------

                  Title:
                        --------------------------------------------------

                  Dated:
                  Account Number (if electronic book entry transfer):

                  Transaction Code Number (if electronic book entry transfer):



[NOTE TO HOLDER -- THIS FORM MUST BE SENT CONCURRENTLY TO TRANSFER AGENT]




                                 ACKNOWLEDGMENT


                  The Company hereby  acknowledges  this  Conversion  Notice and
hereby  directs  Continental  Stock  Transfer & Trust Company to issue the above
indicated  number of shares of Common Stock in accordance  with the  Irrevocable
Transfer  Agent  Instructions  dated January 26, 2004 (as amended on October 24,
2005) from the  Company  and  acknowledged  and agreed to by  Continental  Stock
Transfer & Trust Company.


                                             HEMISPHERX BIOPHARMA, INC.


                                      By:
                                            ------------------------------
                                     Name:
                                            ------------------------------
                                     Title:
                                            ------------------------------










Account Control Agreement...................................................3
Acquiring Entity............................................................16
Act.........................................................................3
Agent.......................................................................3
Approved Stock Plan.........................................................3
ASE.........................................................................3
Bloomberg...................................................................3
Business Day................................................................3
Cap Allocation Amount.......................................................42
Cash Collateral Account.....................................................3
Cash Collateral Account Bank................................................3
Cash Collateral Certificate.................................................41
Cash Interest Payment.......................................................1
Cash Transaction...........................................................3,18
Change of Control...........................................................17
Change of Control Redemption Price..........................................17
Closing Sale Price..........................................................4,7
Collateral..................................................................4
Common Stock...............................................................4,48
Common Stock Deemed Outstanding.............................................4
Company.................................................................1,48,57
Conversion Date.............................................................9
Conversion Failure..........................................................4
Conversion Notice...........................................................9
Conversion Price............................................................4
Conversion Rate.............................................................8
Convertible Securities......................................................4
Debenture..................................................................1,48
Debenture Delivery Date.....................................................9
Debenture Register..........................................................2
Debentures..................................................................1
Default Conversion Price....................................................5
Default Interest............................................................2
Dilutive Issuance...........................................................12
DTC.........................................................................9
Events of Default...........................................................20
Exchange Act................................................................26
Exchange Cap................................................................42
Fixed Conversion Price......................................................5
Holder......................................................................1
Indebtedness................................................................21
Intellectual Property.......................................................5
Interest Payment Date.......................................................1
Interest Payments...........................................................1
Interferon Acquisition......................................................5
Letters of Credit...........................................................5
Mandatory Conversion........................................................8
Mandatory Conversion Date...................................................8
Mandatory Conversion Measuring Period.......................................7
Mandatory Conversion Notice.................................................7
Maturity Date...............................................................1
Maturity Date Mandatory Redemption..........................................11
Maturity Date Redemption Price..............................................11
Mortgage....................................................................5
NASDAQ......................................................................5
New Securities Issuance Price...............................................12
Notice of Change of Control.................................................17
Notice of Redemption Upon Change of Control.................................17
NYSE........................................................................5
Options.....................................................................5
Organic Change..............................................................16
Original Issuance Date......................................................5
Outstanding Principal Amount................................................5
Person......................................................................5
Principal Market............................................................5
Quarterly Period............................................................6
Registration Rights Agreement...............................................6
Rule 144....................................................................26
SEC.........................................................................6
Securities Agreement........................................................6
Securities Purchase Agreement...............................................6
Share Delivery Date.........................................................9
Strategic Financing.........................................................6
Transaction Documents.......................................................6
Transfer Agent..............................................................9
Valuation Event.............................................................14
Warrants....................................................................6
Weighted Average Price......................................................6,7








                                    EXHIBIT A



                            Subordination Provisions

Section 1. Definitions. As used herein, the following terms shall have the
following meanings:

"Borrower" shall mean [Hemispherx][applicable Subsidiary of Hemispherx].

"Hemispherx" shall mean Hemispherx Biopharma, Inc., a corporation duly
organized and existing under the laws of the State of Delaware.

"Loan Documents" shall mean any agreement executed in connection with
the issuance of the Senior Debt, in each case as amended, supplemented
or otherwise modified from time to time.

"Obligations" shall mean the obligations of the Borrower now or
hereafter existing in favor of the holders of the Senior Debt, whether
for principal, interest (including interest accruing subsequent to the
filing of any petition initiating any bankruptcy, insolvency,
arrangement, reorganization or receivership proceedings relating to
the Borrower), fees, expenses or otherwise.

"Senior Debt" shall mean the Borrower's 7% Senior Secured Convertible
Debentures due


"Subordinated Creditor" shall mean                 .
                                  ----------------

"Subordinated Debt" shall mean all indebtedness of the Borrower now or hereafter
existing in favor of the  Subordinated  Creditor,  whether  created  directly or
acquired by assignment or otherwise, all interest thereon and all fees, premiums
and other amounts payable in respect thereof.

"Subordinated Loan Documents" shall mean the instruments and
agreements to which the Borrower is a party evidencing or relating to
any Subordinated Debt.

                  Section 2. Agreement to Subordinate.  Each of the Subordinated
Creditor,  Hemispherx and the Borrower agrees that the Subordinated  Debt is and
shall be subordinate,  to the extent and in the manner hereinafter set forth, in
right of payment to the prior payment in full of the Obligations.

                  Section 3. Restrictions on Payment of the Subordinated Debt.

                  (a) The  Subordinated  Creditor may receive,  and the Borrower
may pay,  interest on the Subordinated  Debt evidenced by the Subordinated  Loan
Documents,  in the stated amounts and on the stated dates of payment  thereof as
set forth in the Subordinated Loan Documents,  provided,  however,  that no such
payments  shall be received or made at any time during which an Event of Default
(as defined in the Senior  Debt) shall have  occurred and be  continuing  on any
Senior Debt.

                  (b) In the event of any dissolution,  winding up, liquidation,
arrangement  or  reorganization  relating to Hemispherx or the Borrower,  in any
bankruptcy, insolvency, arrangement,  reorganization or receivership proceedings
or upon an assignment  for the benefit of creditors or any other  marshalling of
the assets  and  liabilities  of  Hemispherx  or the  Borrower,  any  payment or
distribution  of any kind (whether in cash,  securities or other property) which
otherwise  would  be  payable  or  deliverable  upon  or  with  respect  to  the
Subordinated  Debt shall be paid or  delivered  directly  to the  holders of the
Senior Debt for  application  (in the case of cash) to, or as collateral (in the
case of securities or other non-cash property) for, the payment or prepayment of
the Obligations until the Obligations shall have been paid in full.

                  (c) All payments or distributions  upon or with respect to the
Subordinated  Debt which are received by the Subordinated  Creditor  contrary to
these subordination provisions shall be received in trust for the benefit of the
holders of the Senior Debt for the  ratable  benefit of such  holders,  shall be
segregated from other funds and property held by the  Subordinated  Creditor and
shall be  forthwith  paid over to the holders of the Senior Debt for the ratable
benefit of such  holders  in the same form as so  received  (with any  necessary
endorsement)  to be applied (in the case of cash) to or held as  collateral  (in
the case of securities or other non-cash property) for the payment or prepayment
of the Obligations until the Obligations shall have been paid in full.

                  Section 4.        Obligations Unconditional.


                  (a) All rights and interests of the holders of the Senior Debt
hereunder,  and all agreements and  obligations  of the  Subordinated  Creditor,
Hemispherx  and the  Borrower  hereunder,  shall remain in full force and effect
irrespective of: (i) any lack of validity or enforceability of any Loan Document
or any other agreement or instrument  relating  thereto,  (ii) any change in the
time,  manner or place of payment of, or in any other term in respect of, all or
any of the  Obligations,  or any other  amendment or waiver of or any consent to
departure  from  any Loan  Document,  (iii)  any  exchange  or  release  of,  or
non-perfection  of any lien on or security  interest in, any collateral,  or any
release or amendment or waiver of or consent to departure from any guaranty, for
all or any of the  Obligations,  or (iv)  any  other  circumstance  which  might
otherwise  constitute a defense  available to, or a discharge of,  Hemispherx or
the  Borrower  in  respect  of the  Obligations  or the  Subordinated  Creditor,
Hemispherx or the Borrower in respect of these subordination provisions.

                  (b)  These  subordination  provisions  shall  continue  to  be
effective or shall be reinstated, as the case may be, if at any time any payment
of any of the  Obligations  is  rescinded  or must  otherwise be returned by the
holders of the Senior Debt upon the insolvency,  bankruptcy or reorganization of
Hemispherx or the Borrower or otherwise, all as though such payment had not been
made.

                  Section  5.  Waivers.  Each  of  the  Subordinated   Creditor,
Hemispherx and the Borrower waives (i) promptness and diligence,  (ii) notice of
acceptance  and notice of the  incurrence of any Obligation by Hemispherx or the
Borrower,  (iii) notice of any actions  taken by the holders of the Senior Debt,
Hemispherx  or the Borrower  under any Loan  Document or any other  agreement or
instrument relating thereto, (iv) all other notices,  demands and protests,  and
all other  formalities of every kind in connection  with the  enforcement of the
Obligations or of the obligations of the Subordinated  Creditor,  Hemispherx and
the Borrower under these subordination  provisions,  the omission of or delay in
which,  but for the provisions of this Section 5, might  constitute  grounds for
relieving  the  Subordinated  Creditor,   Hemispherx  or  the  Borrower  of  its
obligations  under these  subordination  provisions and (v) any requirement that
the holders of the Senior Debt protect,  secure,  perfect or insure any security
interest or other lien or any property  subject  thereto or exhaust any right to
take any action against Hemispherx or the Borrower or any other person.

                  Section 6.  Subrogation.  No payment  or  distribution  to the
holders of the Senior Debt  pursuant  to these  subordination  provisions  shall
entitle  the  Subordinated  Creditor to exercise  any rights of  subrogation  in
respect thereof until the Obligations shall have been satisfied in full.

                  Section 7.        Miscellaneous.


                  (a)  Each of the  Subordinated  Creditor,  Hemispherx  and the
Borrower  will,  at its expense and at any time and from time to time,  promptly
execute and deliver all further  instruments and other  documents,  and take all
further  action that the holders of the Senior  Debt may  reasonably  request in
order to reflect the subordination provisions set forth herein.

                  (b) These  subordination  provisions  shall be governed by and
construed in accordance  with the law of the State of New York without regard to
principles  of conflicts  of law or choice of law (other than section  5-1401 of
the New York General  Obligations Law). The parties hereto hereby agree that all
actions or proceedings arising directly or indirectly from or in connection with
these  subordination  provisions shall be litigated only in the Supreme Court of
the State of New York or the  United  States  District  Court  for the  Southern
District of New York located in New York County,  New York.  The parties  hereto
consent to the  jurisdiction  and venue of the foregoing courts and consent that
any process or notice of motion or other application to either of said courts or
a judge  thereof  may be served  inside or outside  the State of New York or the
Southern  District of New York by registered  mail,  return  receipt  requested,
directed as provided in (and service so made shall be deemed  complete  five (5)
days after the same has been posted as aforesaid)  or by personal  service or in
such other  manner as may be  permissible  under the rules of said  courts.  The
parties  hereto  hereby waive any right to a jury trial in  connection  with any
litigation pursuant to these subordination provisions.







                                    EXHIBIT B

                                    Inventory







                                    EXHIBIT C
                       FORM OF CASH COLLATERAL CERTIFICATE
IN NO EVENT SHALL THIS  CERTIFICATE  BE DELIVERED BY OR ON BEHALF OF THE COMPANY
TO ANY HOLDER OF DEBENTURES  WITHOUT THE EXPRESS  PRIOR WRITTEN  CONSENT OF SUCH
HOLDER.

CERTIFICATE TO BE DELIVERED ONLY TO THE RECIPIENT DESIGNATED BELOW.

To:

Eleazer Klein, Esq.
Schulte Roth & Zabel LLP
919 Third Avenue
New York, NY  10022
Telephone:  (212) 756-2000
Facsimile:   (212) 593-5955

The  undersigned,  the duly elected  [Chief  Executive  Officer/Chief  Financial
Officer] of HEMISPHERX BIOPHARMA, INC. (the "Company"),  hereby certifies to the
holders of the 7% Senior Secured Convertible Debentures Due June 30, 2007 of the
Company (the "Debentures") pursuant to Section 25(g)(v) of the Debentures,  that
the following information is true and correct in all respects (capitalized terms
used in this certificate and not defined herein shall have the meanings ascribed
to them in the Debentures):

         Cash Collateral Date :                       .
                              ------------------------

         Qualified Inventory Financing Date (if applicable):                .
                                                            ----------------
         Qualified Mortgage Financing Date (if applicable):                 .
                                                            ----------------
         Amount of Cash Collateral Payment: $                               .
                                             -------------------------------
         Amount of Cash Collateral Payment Made in Cash: $                  .
                                                          ------------------
         Aggregate Dollar Value of Cash Collateral Payments Made in Repayment
Shares (if              applicable): $             .
                                      -------------
         Aggregate Number of Repayment Shares Issued (if applicable):       .
                                                                     -------
         Equity Collateral Conversion Rate (if applicable):                 .
                                                           -----------------
         Company Consolidated  Revenues for the relevant period (if applicable):
$             .
- --------------
         Aggregate Amount of Cash Collateral Payments Made Prior to this Cash
Collateral Date:$                  .
                -------------------


         IN WITNESS WHEREOF, the undersigned has executed this certificate as of
this       day of          , 200 .
    -------     -----------     -
                                             ------------------------








                                    HEMISPHERX BIOPHARMA, INC.


                              By:
                                   ------------------------------
                             Name:
                                   ------------------------------
                            Title:
                                   ------------------------------