Exhibit 5.1
                        SILVERMAN SCLAR SHIN & BYRNE PLLC
                        381 Park Avenue South, Suite 1601
                            New York, New York 10016
                              Tel. No. 212-779-8600
                        Telecopy Number - (212) 779-8858

                                                               November 18, 2005

Board of Directors
Hemispherx Biopharma, Inc.
1617 JFK Boulevard
Philadelphia, PA 19103


      Re: Hemispherx Biopharma, Inc. - Registration Statement on Form S-8
         ---------------------------------------------------------------

Gentlemen:

At your request,  we have examined the Registration  Statement on Form S-8 to be
filed with the Securities and Exchange Commission (the "SEC") in connection with
the registration  under the Securities Act of 1933, as amended,  of an aggregate
of  5,578,650  shares  (the  "Shares")  of your  common  stock,  $.001 par value
("Common  Stock")  issuable  upon  exercise  of  warrants  issued by  Hemispherx
Biopharma,  Inc.  (the  "Company") in  connection  with the Company's  Officers,
Directors, And Employees Stock Compensation Program - 1996, Officers,  Directors
And  Employees  Stock  Compensation  Program  - 1998,  Officers,  Directors  And
Employees Stock Compensation Program - 2001,  Officers,  Directors And Employees
Stock  Compensation  Program - 2002 and Officers,  Directors And Employees Stock
Compensation Program - 2003 (collectively, the "Plans").

We have  reviewed and are familiar  with such  corporate  proceedings  and other
matters as we have deemed necessary for this opinion.  Based upon the foregoing,
it is our opinion that the Shares,  when issued and outstanding  pursuant to the
terms of the Plans, will be validly issued, fully paid and nonassessable.

This opinion is limited to matters  governed by the General  Corporation  Law of
the State of Delaware.  No opinion is expressed as to the effect that the law of
any other jurisdiction may have upon the subject matter of the opinion expressed
herein under conflicts of law principles, rules and regulations or otherwise.

This opinion is limited to the specific issues addressed herein,  and no opinion
may be inferred or implied  beyond that expressly  stated  herein.  We assume no
obligation to revise or supplement  this opinion  should the present laws of the
State of  Delaware  be changed  by  legislative  action,  judicial  decision  or
otherwise.

We  hereby  consent  to  the  filing  of  this  opinion  as  Exhibit  5.1 to the
Registration  Statement  and to the use of our name  under  the  caption  "Legal
Matters" in the Registration  Statement and in the Prospectus  included therein.
In giving this consent,  we do not thereby admit that we are within the category
of persons whose consent is required under Section 7 of the Act or the rules and
regulations of the Securities and Exchange Commission promulgated thereunder.

This  opinion  is  furnished  to  you  in  connection  with  the  filing  of the
Registration  Statement and is not to be used,  circulated,  quoted or otherwise
relied upon for any other purposes.


                                      Very truly yours,

                                     /s/ Silverman Sclar Shin & Byrne PLLC
                                     ------------------------------------
                                     Silverman Sclar Shin & Byrne PLLC