Exhibit 16.1 [PricewaterhouseCoopers Logo] PricewaterhouseCoopers LLP Southwark Towers, 32 London Bridge St London SE1 9SY Telephone +44 (0) 20 7583 5000 Facsimile +44 (0) 20 7822 4652 March 27. 2003 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Commissioners: We have read the statements made by Orthofix International N.V. (copy attached), which we understand will be filed with the Commission, pursuant to Item 9 of the Company's Form 10-K report for the year ended December 31, 2002. We agree with the statements concerning our Firm in such Form 10-K. Very truly yours, /s/PricewaterhouseCoopers PricewaterhouseCoopers Enclosures