SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT

     
This Second Amendment to Loan and Security Agreement ("Amendment")
is dated  February 22, 1996 and entered into by and among HELLER
FINANCIAL, INC.  ("Lender"), and PERMA-FIX ENVIRONMENTAL SERVICES,
INC. ("Parent") and all those direct and indirect subsidiaries of
Parent whose names are inscribed on the signature pages of the
Agreement as defined below ("Borrowers").

     WHEREAS, Lender, Parent and Borrowers have entered into a Loan
and Security Agreement (the "Agreement") dated January 27, 1995;
and
     
     WHEREAS, Parent has advised Lender of its intention to issue
up to 2,500 shares of Series 2, Class B Preferred Stock; and

     WHEREAS, Parent has requested Lender amend the Agreement as it
relates to said Second Offering; and

     WHEREAS, Parent has requested Lender amend the Agreement as it
relates to the issuance of common stock upon conversion of the
Shares and the Second Offering Shares; and  

     WHEREAS, Lender has agreed to said amendments to the
Agreement;

     NOW THEREFORE, in consideration of the mutual conditions and
agreements set forth in the Agreement and this Amendment, and other
good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the parties, intending to be legally
bound, hereby agree as follows:


ARTICLE I. DEFINITIONS

     Section 1.01.  Definitions.  Capitalized terms used in this
Amendment, to the extent not otherwise defined herein, shall have
the same meanings as in the Agreement, as amended hereby.  The
definition of "Offering" contained in the First Amendment to the
Loan and Security Agreement dated February 9, 1986 shall be deleted
and a new definition inserted therefor.  In addition, the following
definitions shall be added, in proper alphabetical order, to
Subsection 1.1 of the Agreement, entitled "Certain Defined Terms":
  
  "Offering" shall mean that certain Offshore Securities
  Subscription Agreement dated February 9, 1996, which when
  executed by the parties thereto, will transfer all or a part of
  the Shares.



  "Resolution" shall mean that certain Resolution of the Board of
  Directors of Parent Fixing the Number and Designating the
  Rights, Privileges, Restrictions and Conditions Attaching to the
  Series I, Class A Preference Shares, adopted February 2, 1996,
  authorizing the Shares.
                                    
  "Second Offering" shall mean that certain Offshore Securities
  Subscription Agreement dated February 22, 1996, which when
  executed by the parties thereto, will  transfer all or a part of
  the Second Offering Shares.
                                    
  "Second Offering Shares" shall mean up to 2,500 shares of Series
  2, Class B Preferred Stock of Parent.
                                    
  "Shares" shall mean 1,100 shares of Series I, Class A Preference
  Shares of Parent authorized pursuant to the Resolution. 
                                    
  "Unanimous Consent" shall mean that certain Unanimous Written
  Consent to the Actions of The Board of Directors of Parent,
  adopted February 22, 1996, authorizing the Second Offering
  Shares.
  
                        ARTICLE II.  AMENDMENTS 

  Section 2.01.  Amendment to Subsection 7.5 "Restricted Junior
Payments".  Subsection 7.5 shall be, and the same is hereby amended
by deleting the word "and" immediately preceding clause (b) and
inserting at the end of clause (b) the following:

  "and (c) Parent may pay a dividend to each holder of Second
  Offering Shares in an amount not to exceed $12.50 per share per
  quarter during the period said Second Offering Shares shall be
  issued and outstanding."

  Section 2.02.  Amendment to Subsection 7.6 "Restriction on
Fundamental Changes".  Subsection 7.6(e) shall be, and the same is
hereby amended by deleting the remainder of said subsection
following the words ", provided however," and substituting therefor
the following:

  ", provided however, Parent may issue (i) the Shares pursuant to
  the Offering, (ii) the Second Offering Shares, (iii) shares of
  common stock upon conversion of the Shares and (iv) shares of
  common stock upon conversion of the Second Offering Shares.


ARTICLE III.  MISCELLANEOUS
                                    
  Section 3.01.  Conditions.  The effectiveness of this Amendment
is subject to the satisfaction of the following conditions
precedent (unless specifically waived in writing by Lender):  (a)
there shall have occurred no material adverse change in the
business, operations, financial conditions, profits or prospects,
or in the Collateral or the Borrower; (b) Borrower shall have
executed and delivered such other documents and instruments as
Lender may require; (c) Borrower shall have paid Lender a fee in
the amount of $500.00 as and for the issuance of this Amendment;
and (d) all corporate proceedings taken in connection with the
transactions contemplated by this Amendment and all documents,
instruments and other legal matters incident thereto shall be
satisfactory to Lender and its legal counsel.

  Section 3.02  Ratification.  The terms and provisions set forth
in this Amendment shall modify and supersede all inconsistent terms
and provisions set forth in the Agreement and, except as expressly
modified and superseded by this Amendment, the terms and provisions
of the Agreement, are ratified and confirmed and shall continue in
full force and effect.  Nothing contained herein shall  be con-
strued as the consent of Lender to any other matters prohibited
under the Agreement, specifically including Lender's consent to
Parent's redemption of (a) Shares pursuant to Part 4 of the
Resolution and (b) Second Offering Shares pursuant to Part 4 of the
Unanimous Consent.

  Section 3.03  Corporate Action  The execution, delivery and
performance of this Amendment have been authorized by all requisite
corporate action on the part of Borrower and will not violate the
Articles of Incorporation or Bylaws of Borrower.

  Section 3.04  Severability.  Any provision of this Amendment held
by a court of competent jurisdiction to be invalid or unenforceable
shall not impair or invalidate the remainder of this Amendment and
the effect thereof shall be confined to the provision so held to be
invalid or unenforceable.

  Section 3.05  Successors and Assigns.  This Amendment is binding
upon and shall inure to the benefit of Lender and Borrower and
their respective successors and assigns;

  Section 3.06  Counterparts.  This Amendment may be executed in
one or more counterparts, each of which when so executed shall be
deemed to be an original, but all of which when taken together
shall constitute one and the same instrument.


  IN WITNESS WHEREOF, the parties have executed this Amendment on
the date first above written.
                           
                           Lender:
            
                           HELLER FINANCIAL, INC., a Delaware
                           corporation

                           By: /s/ Nancy Stafford
                               ________________________________
                           
                           Title: AVP                            
                                 _____________________________
                           
                           Parent:

                           PERMA-FIX ENVIRONMENTAL
                           SERVICES, INC., a Delaware corporation

                           By: /s/ Louis F. Centofanti
                                  ______________________________        
                                Name: Louis F. Centofanti
                                     _________________________
                              Title: CEO                      
                                     _________________________

                           Attest: /s/ Richard T. Kelecy         
                                     ___________________________
                                 Name: Richard T. Kelecy      
                                      ______________________
                                 Title: CFO                      
                                       ______________________

                           Borrowers:

                           INDUSTRIAL WASTE MANAGEMENT,
                           INC., a Missouri corporation
                                          
                           By: /s/ Louis F. Centofanti
                                  ______________________________
                              Name: Louis F. Centofanti
                                    __________________________
                              Title: CEO                      
                                     __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________


                           PERMA-FIX, INC., an Oklahoma
                           corporation

                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                    __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________


                           PERMA-FIX OF DAYTON, INC.,
                           an Ohio corporation

                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                  __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                      _______________________


                           PERMA-FIX OF FLORIDA, INC.,
                           a Florida corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________


                           PERMA-FIX OF FORT LAUDERDALE,
                           INC., a Florida corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                  __________________________
                              Title: CEO                      
                                  __________________________

                          Attest: /s/ Richard T. Kelecy         
                                 ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                      _______________________


                           PERMA-FIX OF MEMPHIS, INC.,
                           a Tennessee corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                  __________________________
                              Title: CEO                      
                                  __________________________

                           Attest: /s/ Richard T. Kelecy         
                                 ____________________________
                                 Name: Richard T. Kelecy         
                                     ________________________
                                 Title: CFO                     
                                      _______________________

                           PERMA-FIX OF NEW MEXICO, INC.,
                           a New Mexico corporation

                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                 ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     


                           PERMA-FIX TREATMENT SERVICES,
                           INC., an Oklahoma corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                  Name: Richard T. Kelecy         
                                        ________________________
                                  Title: CFO                     
                                        _______________________


                           SCHREIBER, GRANA & YONLEY,
                           INC., a Missouri corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________


                           MINTECH, INC., an Oklahoma
                           corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                  __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                  ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________



                           RECLAMATION SYSTEMS, INC., an
                           Oklahoma corporation


                           By: /s/ Louis F. Centofanti
                              ______________________________
                              Name: Louis F. Centofanti
                                   __________________________
                              Title: CEO                      
                                   __________________________

                           Attest: /s/ Richard T. Kelecy         
                                 ____________________________
                                 Name: Richard T. Kelecy         
                                      ________________________
                                 Title: CFO                     
                                       _______________________