<ARTICLE> 5 <CIK> 0001010915 <NAME> MICROCIDE PHARMACEUTICALS, INC. <MULTIPLIER> 1,000 <CURRENCY> U.S. DOLLARS <PERIOD-TYPE> 3-MOS <FISCAL-YEAR-END> DEC-31-2000 <PERIOD-START> JAN-01-2000 <PERIOD-END> MAR-31-2000 <EXCHANGE-RATE> 1 <CASH> 4,704 <SECURITIES> 16,230 <RECEIVABLES> 849 <ALLOWANCES> 0 <INVENTORY> 0 <CURRENT-ASSETS> 22,093 <PP&E> 20,027 <DEPRECIATION> (12,823) <TOTAL-ASSETS> 30,220 <CURRENT-LIABILITIES> 3,408 <BONDS> 0 <PREFERRED-MANDATORY> 0 <PREFERRED> 0 <COMMON> 67,888 <OTHER-SE> (42,837) <TOTAL-LIABILITY-AND-EQUITY> 30,220 <SALES> 0 <TOTAL-REVENUES> 1,133 <CGS> 0 <TOTAL-COSTS> 4,899 <OTHER-EXPENSES> 0 <LOSS-PROVISION> 0 <INTEREST-EXPENSE> 77 <INCOME-PRETAX> (3,520) <INCOME-TAX> 0 <INCOME-CONTINUING> (3,520) <DISCONTINUED> 0 <EXTRAORDINARY> 0 <CHANGES> 0 <NET-INCOME> (3,520) <EPS-BASIC> (0.31) <EPS-DILUTED> (0.31)