As filed with the Securities and Exchange Commission on April 2, 1996
                                                       Registration No. 33-64575
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   ----------

                         POST-EFFECTIVE Amendment No. 1
                       TO FORM S-4 REGISTRATION STATEMENT
                  UNDER THE SECURITIES ACT OF 1933 ON FORM S-8

                             ----------------------

                              WELLS FARGO & COMPANY
               (Exact name of issuer as specified in its charter)

          Delaware                                  13-2553920
(State or other jurisdiction              (I.R.S. Employer Identification No.)
of incorporation or organization)

                                   ----------

                              420 Montgomery Street
                         San Francisco, California 94163
                                 (415) 477-1000
    (Address, including zip code, and telephone number, including area code,
                        of principal executive offices)

                                   ----------

                    1991 PERFORMANCE STOCK PLAN (AS AMENDED)
               1991 DIRECTOR OPTION PLAN (AS AMENDED AND RESTATED)
                           1988 PERFORMANCE STOCK PLAN
                    1983 PERFORMANCE STOCK PLAN (AS AMENDED)
                           (Full titles of the plans)

                                   ----------

                              Guy Rounsaville, Jr.
              Executive Vice-President, Chief Counsel and Secretary
                              420 Montgomery Street
                         San Francisco, California 94163
                                 (415) 477-1000
(Name, address and telephone number, including area code, of agent for service)

                                   ----------

This Post-Effective  Amendment No. 1 to Form S-4 Registration  Statement on Form
S-8 relates to options to purchase shares of the Common Stock,  $2.00 par value,
of First Interstate Bancorp, a Delaware corporation ("First Interstate"),  which
were assumed by Wells Fargo & Company (the "Registrant") upon the effective time
of a merger of First Interstate with and into the Registrant,  on April 1, 1996.
Such options are now  exercisable  to purchase  shares of Common Stock par value
$5.00 per share,  of the  Registrant  ("Common  Stock").  These shares of Common
Stock were originally registered on the Registrant's  Registration  Statement on
Form S-4 to which this is an amendment;  accordingly,  the  registration  fee in
respect of such Common Stock was paid at the time of the original  filing of the
Registration Statement relating to such Common Stock.

================================================================================



                                     PART II

               Information Required in the Registration Statement

Item 3.  Incorporation of Certain Documents by Reference

         The Registrant hereby  incorporates by reference into this Registration
Statement the  following  documents  previously  filed with the  Securities  and
Exchange Commission (the "Commission"):

         (a)  The  Registrant's  Annual Report filed with the Commission on Form
              10-K,  File No.  01-06214,  for the fiscal year ended December 31,
              1995   (excluding   the information contained therein described in
              Item 402(a)(8) of the Commission's Regulation S-K);

         (b)  The Registrant's Current Reports filed with the Commission on Form
              8-K,  File No.  01-06214,  on January 16, 1996,  January 24, 1996,
              January 31, 1996 and February 29, 1996;

         (c)  The Registrant's  Registration Statement filed with the Commission
              on Form S-4, File No. 33-64575;

         (d)  The  description  of Common Stock  contained  in the  Registrant's
              Registration Statement on Form 8-B, File No. 01-06214,  filed with
              the Commission on June 17, 1987; and any amendment or report filed
              for the purposes of updating such description filed after the date
              of this Amendment; and

         (e)  First Interstate Bancorp's Annual Report filed with the Commission
              on Form  10-K,  File  No.  61-06214,  for the  fiscal  year  ended
              December  31,  1995  (excluding   information   obtained   therein
              described in Item 402(a)(8) of the Commission's Regulation S-K).

  
         All  reports  and  definitive  proxy or  information  statements  filed
pursuant to Section 13(a),  13(c), 14 or 15(d) of the Securities Exchange Act of
1934, as amended (the "1934 Act") after the date of this Registration  Statement
and prior to the filing of a  post-effective  amendment which indicates that all
securities  offered  hereby have been sold or which  deregisters  all securities
then remaining  unsold shall be deemed to be incorporated by reference into this
Registration  Statement  and to be a part hereof from the date of filing of such
documents.  Any statement  contained herein or in a document all or a portion of
which is incorporatd or deemed to be  incorporated  by reference herein shall be
deemed to be modified or  superseded  for  purposes  of this  Prospectus  to the
extent  that a statement  contained  herein or in any other  subsequently  filed
document  that also is or is  deemed  to be  incorporated  by  reference  herein
modifies  or  supersedes  such  statement.  Any such  statement  so  modified or
superseded  shall  not be  deemed,  except  as so  modified  or  superseded,  to
constitute a part of this Prospectus.

Item 4.  Description of Capital Stock

               Inapplicable.

Item 5.  Interests of Named Experts and Counsel

               Inapplicable.


                                      II-1.



Item 6.  Indemnification of Directors and Officers

         As permitted by Section  102(b)(7) of the Delaware General  Corporation
Law  ("DCGL"),  Article  Fifth of the the Registrant certificate  eliminates the
monetary  liability of a director to the  corporation  or its  stockholders  for
breach of  fiduciary  duty as a  director,  with the  following  exceptions,  as
required by Delaware  law: (i) breach of the  director's  duty of loyalty to the
corporation  or its  stockholder;  (ii) acts or  omissions  not in good faith or
which  involve  intentional  misconduct  or a knowing  violation  of law;  (iii)
payment of unlawful  dividends  or the making of  unlawful  stock  purchases  or
redemptions; or (iv) any transaction from which the director derived an improper
personal benefit.

         In addition, under Section 145 of the DGCL, a corporation may indemnify
a director,  officer,  employee  or agent of the  corporation  against  expenses
(including  attorneys'  fees),  judgments,  fines and amounts paid in settlement
actually  and  reasonably  incurred by him in  connection  with any  threatened,
pending or completed  Proceeding (other than an action by or in the right of the
corporation)  if he acted in good  faith  and in a  manner  which he  reasonably
believed to be in or not opposed to the best interests of the  corporation  and,
with respect to any criminal  action or proceeding,  had no reasonable  cause to
believe his conduct was unlawful.  In the case of an action brought by or in the
right of the  corporation,  the corporation  may indemnify a director,  officer,
employee or agent of the  corporation  against  expenses  (including  attorneys'
fees) actually and reasonably  incurred by him in connection with the defense or
settlement of any threatened, pending or completed action or suit if he acted in
good faith and in a manner he reasonably believed to be in or not opposed to the
best interests of the corporation,  except that no indemnification shall be made
in respect of any claim, issue or matter as to which such person shall have been
adjudged  to be liable to the  corporation  unless and only to the extent that a
court determines upon application  that, in view of all the circumstances of the
case,  such  person is fairly and  reasonably  entitled  to  indemnity  for such
expenses  as the court  deems  proper.  Article  IV of the  Registrant's  Bylaws
(Exhibit 3.2 hereto) provides for  indemnification  of its directors,  officers,
employees, and other agents to the fullest extent permitted by the DGCL.

Item 7.  Exemption from Registration Claimed

               Inapplicable.

Item 8.  Exhibits

Exhibit Number    Exhibit

    4.1           Agreement and Plan of Merger, dated as of January 23, 1996, by
                  and  between the Registrant and First  Interstate  Bancorp, as
                  amended as of February  23,  1996,  excluding  all annexes and
                  schedules,  incorporated  by  reference  to  Appendix A to the
                  Joint  Proxy  Statement  of WF &   Company  and First
                  Interstate Bancorp and the Prospectus of Wells Fargo & Company
                  dated  February 27,  1996.  The  Registrant  agrees to furnish
                  supplementally  copies of omitted annexes and schedules to the
                  Commission upon request.*
    4.2           Restated  Certificate of Incorporation of the Registrant dated
                  March 3, 1987,  incorporated  by  reference to Exhibit 3(a) to
                  the Registrant's Annual Report on Form 10-K for the year ended
                  December 31, 1993.*
    4.3           Bylaws  of  the   Registrant,   as  amended  April  18,  1995,
                  incorporated by reference to Exhibit 3(e) to the  Registrant's
                  Annual  Report on Form 10-K for the year  ended  December  31,
                  1995*
    5             Opinion of Sullivan & Cromwell*
    23.1          Consent of KMPG Peat Marwick LLP
    23.2          Consent of Ernst & Young LLP
    23.3          Consent of Sullivan & Cromwell is contained in Exhibit 5
    24            Power of  Attorney  (included  on  signature  page of original
                  filing)*
    99.1          1991  Performance  Stock Plan (as  amended)  (incorporated  by
                  reference to First Interstate Bancorp's Registration Statement
                  No. 33-38903 on Form S-8)*

                                      II-2.



    99.2          First  Amendment  to  the  1991  Performance  Stock  Plan   
    99.3          Second Amendment to the 1991 Performance Stock Plan    
    99.4          Third Amendment to the 1991 Performance Stock Plan
    99.5          1991   Director   Option  Plan  (as   amended  and   restated)
                  (incorporated  by  reference  to  First  Interstate  Bancorp's
                  Registration Statement No. 33-37299 on Form S-8)*
    99.6          First Amendment to the 1991 Director Option Plan
    99.7          1988  Performance  Stock Plan  (incorporated  by  reference to
                  First Interstate Bancorp's Registration Statement No. 33-23404
                  on Form S-8)*
    99.8          First Amendemnt to the 1988 Performance Stock Plan
    99.9          Second Amendment to the 1988 Performance Stock Plan
    99.10         1983  Performance  Stock Plan (as  amended)  (incorporated  by
                  reference to First Interstate Bancorp's Registration Statement
                  No. 2-82812 on Form S-8)*
    99.11         First Amendment to the 1983 Performance Stock Plan
    99.12         Second Amendment to the 1983 Performance Stock Plan
    99.13         Third Amendment to the 1983 Performance Stock Plan

- ---------------------
*  Previously filed


Item 9.  Undertakings.

                  A. The undersigned Registrant hereby undertakes:  (1) to file,
during  any period in which  offers or sales are being  made,  a  post-effective
amendment to this Registration  Statement (i) to include any prospectus required
by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts
or events  arising after the effective date of this  Registration  Statement (or
the most recent post-effective amendment thereof) which,  individually or in the
aggregate,  represent a fundamental  change in the information set forth in this
Registration  Statement,  and (iii) to include  any  material  information  with
respect  to  the  plan  of  distribution   not  previously   disclosed  in  this
Registration  Statement  or any  material  change  to such  information  in this
Registration Statement; provided, however, that clauses (1)(i) and (1)(ii) shall
not apply if the  information  required  by those  clauses to be  included  in a
post-effective  amendment  is contained  in the  periodic  reports  filed by the
Registrant  pursuant  to Section  13 or  Section  15(d) of the 1934 Act that are
incorporated by reference into this  Registration  Statement;  (2) that, for the
purpose  of   determining   any   liability   under  the  1933  Act,  each  such
post-effective  amendment  shall be  deemed to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering  thereof;  and
(3) to remove from  registration by means of a  post-effective  amendment any of
the securities  being  registered  which remain unsold at the termination of the
offering.

                  B. The  undersigned  Registrant  hereby  undertakes  that, for
purposes of  determining  any  liability  under the 1933 Act, each filing of the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
1934 Act that is  incorporated  by reference  into this  Registration  Statement
shall be deemed to be a new  registration  statement  relating to the securities
offered  therein,  and the  offering  of such  securities  at that time shall be
deemed to be the initial bona fide offering thereof.

                  C. Insofar as  indemnification  for liabilities  arising under
the 1933 Act may be permitted to directors,  officers or controlling  persons of
the Registrant  pursuant to the  provisions and agreements  summarized in Item 6
above or otherwise,  the  Registrant has been advised that in the opinion of the
Commission  such  indemnification  is against  public policy as expressed in the
1933  Act  and is,  therefore,  unenforceable.  In the  event  that a claim  for
indemnification  against  such  liabilities  (other  than  the  payment  by  the
Registrant of expenses  incurred or paid by a director,  officer or  controlling
person of the  Registrant  in the  successful  defense  of any  action,  suit or
proceeding)  is  asserted by such  director,  officer or  controlling  person in
connection with the securities being registered,  the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit  to a  court  of  appropriate  jurisdiction  the  question  whether  such
indemnification  by it is against public policy as expressed in the 1933 Act and
will be governed by the final adjudication of such issue.

                                      II-3.




                                   SIGNATURES

         Pursuant to the  requirements of the Securities Act, the Registrant has
duly  caused  this  Post-Effective  Amendment  No. 1 on Form S-8 to be signed on
behalf  by the  undersigned,  thereunto  duly  authorized,  in the  City  of San
Francisco, State of California, on this 2nd day of April, 1996.

                                     Wells Fargo & Company

                                     By   /s/  RODNEY L. JACOBS
                                       -----------------------------------------
                                       Rodney L. Jacobs
                                       Vice Chairman and Chief Financial Officer

         Pursuant to the  requirements  of the 1933 Act,  this  Amendment to the
Registration  Statement  has been signed below by the  following  persons in the
capacities and on the dates indicated.

Signatures                    Title                                   Date


/s/  PAUL HAZEN               Chairman of the Board,             April 1, 1996
- -------------------------     Chief Executive Officer
Paul Hazen                    and Director (Principal
                              Executive Officer)


/s/  RODNEY L. JACOBS         Vice Chairman and Chief            April 1, 1996
- -------------------------     Financial Officer (Principal
Rodney L. Jacobs              Financial Officer)

     
/s/  FRANK A. MOESLEIN        Executive Vice President           April 1, 1996
- -------------------------     and Controller (Principal
Frank A. Moeslein             Accounting Officer)


/s/  H. JESSE ARNELLE         Director                           April 1, 1996
- -------------------------     
H. Jesse Arnelle


/s/  WILLIAM R. BREUNER       Director                           April 1, 1996
- -------------------------     
William R. Breuner


/s/  WILLIAM S. DAVILA        Director                           April 1, 1996
- -------------------------     
William S. Davila


/s/  RAYBURN S. DEZEMBER      Director                           April 1, 1996
- -------------------------     
Rayburn S. Dezember


/s/  ROBERT K. JAEDICKE       Director                           April 1, 1996
- -------------------------     
Robert K. Jaedicke





                                      II-4.



Signatures                    Title                                   Date

/s/  ELLEN M. NEWMAN          Director                           April 1, 1996
- -------------------------     
Ellen M. Newman


/s/  PHILIP J. QUIGLEY        Director                           April 1, 1996
- -------------------------     
Philip J. Quigley


/s/  CARL E. REICHARDT        Director                           April 1, 1996
- -------------------------     
Carl E. Reichardt


/s/  DONALD B. RICE           Director                           April 1, 1996
- -------------------------     
Donald B. Rice


/s/  SUSAN G. SWENSON         Director                           April 1, 1996
- -------------------------     
Susan G. Swenson


/s/  CHANG-LIN TIEN           Director                           April 1, 1996
- -------------------------     
Chang-Lin Tien


/s/  JOHN A. YOUNG            Director                           April 1, 1996
- -------------------------     
John A. Young


/s/  WILLIAM F. ZUENDT        Director                           April 1, 1996
- -------------------------     
William F. Zuendt



*By: /s/ RODNEY L. JACOBS
- -------------------------     
    Attorney-in-Fact
    Rodney L. Jacobs


                              Director
- -------------------------     
Edward M. Carson


                              Director
- -------------------------     
Myron Du Bain


                              Director
- -------------------------     
Don C. Frisbee


                              Director
- -------------------------     
Thomas L. Lee


                              Director
- -------------------------     
William F. Miller


                              Director
- -------------------------     
Richard J. Stegemeier


                              Director
- -------------------------     
Daniel M. Tellep

                                      II-5.










                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    EXHIBITS

                                       TO

                                    FORM S-8

                                      UNDER

                             SECURITIES ACT OF 1933


                              Wells Fargo & Company






                                  EXHIBIT INDEX



Exhibit Number                       Exhibit
- --------------                       -------
    23.1          Consent of KMPG Peat Marwick LLP
    23.2          Consent of Ernst & Young LLP
    99.2          First  Amendment  to  the  1991  Performance  Stock  Plan 
    99.3          Second Amendment to the 1991 Performance Stock Plan
    99.4          Third Amendment to the 1991 Performance Stock Plan
    99.6          First  Amendment to the 1991 Director  Option Plan
    99.8          First Amendment to the 1988 Performance Stock Plan
    99.9          Second Amendment to the 1988 Performance Stock Plan
    99.11         First Amendment to the 1983 Performance Stock Plan
    99.12         Second Amendment to the 1983 Performance Stock Plan
    99.13         Third Amendment to the 1983 Performance Stock Plan