ATLANTIC PHARMACEUTICALS, INC.
                             1995 STOCK OPTION PLAN
                      as amended and restated June 9, 1996


                                   ARTICLE ONE

                               GENERAL PROVISIONS


        I.        PURPOSE OF THE PLAN

                  This  1995  Stock  Option  Plan is  intended  to  promote  the
interests  of  Atlantic  Pharmaceuticals,   Inc.,  a  Delaware  corporation,  by
providing  eligible  persons  with the  opportunity  to  acquire  a  proprietary
interest,  or otherwise increase their proprietary  interest, in the Corporation
as an incentive for them to remain in the service of the Corporation.

                  Capitalized  terms  shall have the  meanings  assigned to such
terms in the attached Appendix.

       II.        STRUCTURE OF THE PLAN

                  A.  The  Plan  shall  be  divided  into  two  separate  equity
programs:

                                  (i) the  Discretionary  Option  Grant  Program
         under  which  eligible  persons  may,  at the  discretion  of the  Plan
         Administrator,  be granted  options to purchase shares of Common Stock,
         and

                                  (ii) the Automatic  Option Grant Program under
         which Eligible Directors shall  automatically  receive option grants at
         periodic intervals to purchase shares of Common Stock.

                  B. The  provisions of Articles One and Four shall apply to all
equity programs under the Plan and shall accordingly govern the interests of all
persons under the Plan.

      III.        ADMINISTRATION OF THE PLAN

                  A.  The  Primary  Committee  shall  have  sole  and  exclusive
authority to administer the  Discretionary  Option Grant Program with respect to
Section 16 Insiders.  No non-employee Board member shall be eligible to serve on
the Primary  Committee  if such  individual  has,  during the twelve  (12)-month
period immediately preceding the date of his or her appointment to the Committee
or (if shorter) the period commencing with the




Section  12(g)  Registration  Date  and  ending  with  the  date  of  his or her
appointment to the Primary  Committee,  received an option grant or direct stock
issuance  under the Plan or any other stock option,  stock  appreciation,  stock
bonus or other  stock plan of the  Corporation  (or any  Parent or  Subsidiary),
other than pursuant to the Automatic Option Grant Program.

                  B.  Administration of the  Discretionary  Option Grant Program
with respect to all other persons  eligible to  participate in that program may,
at the Board's  discretion,  be vested in the Primary  Committee  or a Secondary
Committee,  or the Board may retain the power to administer  those programs with
respect to all such persons. The members of the Secondary Committee may be Board
members who are  Employees  eligible to receive  discretionary  option grants or
direct  stock  issuances  under  the  Plan  or any  other  stock  option,  stock
appreciation,  stock bonus or other stock plan of the Corporation (or any Parent
or Subsidiary).

                  C. Members of the Primary Committee or any Secondary Committee
shall  serve  for such  period of time as the  Board  may  determine  and may be
removed by the Board at any time.  The Board may also at any time  terminate the
functions of any  Secondary  Committee  and  reassume  all powers and  authority
previously delegated to such committee.

                  D.  Each Plan  Administrator  shall,  within  the scope of its
administrative  functions  under the  Plan,  have full  power and  authority  to
establish  such  rules and  regulations  as it may deem  appropriate  for proper
administration  of the  Discretionary  Option  Grant  Program  and to make  such
determinations  under, and issue such interpretations of, the provisions of such
program and any  outstanding  options  thereunder  as it may deem  necessary  or
advisable.  Decisions  of  the  Plan  Administrator  within  the  scope  of  its
administrative  functions  under  the Plan  shall be final  and  binding  on all
parties who have an interest in the Discretionary Option Grant Program under its
jurisdiction or any option thereunder.

                  E. Service on the Primary Committee or the Secondary Committee
shall constitute  service as a Board member,  and members of each such committee
shall accordingly be entitled to full indemnification and reimbursement as Board
members for their service on such committee.  No member of the Primary Committee
or the Secondary  Committee shall be liable for any act or omission made in good
faith with respect to the Plan or any option grants under the Plan.

                  F.  Administration of the Automatic Option Grant Program shall
be self-  executing in accordance  with the terms of that  program,  and no Plan
Administrator shall exercise any discretionary  functions with respect to option
grants made thereunder.


                                       2.



      IV.         ELIGIBILITY

                  A. The persons  eligible to participate  in the  Discretionary
Option Grant Program are as follows:

                                  (i) Employees,

                                  (ii) non-employee  members of the Board (other
         than those serving as members of the Primary Committee) or the board of
         directors of any Parent or Subsidiary, and

                                  (iii)   consultants   and  other   independent
         advisors  who  provide  services to the  Corporation  (or any Parent or
         Subsidiary).

                  B.  Each Plan  Administrator  shall,  within  the scope of its
administrative  jurisdiction under the Plan, have full authority (subject to the
provisions  of the Plan) to  determine,  with respect to the option grants under
the  Discretionary  Option Grant Program,  which eligible persons are to receive
option  grants,  the time or times when such option  grants are to be made,  the
number of shares to be covered  by each such  grant,  the status of the  granted
option as either an  Incentive  Option or a  Non-Statutory  Option,  the time or
times at which each option is to become exercisable and the vesting schedule (if
any)  applicable  to the option shares and the maximum term for which the option
is to remain outstanding.

                  C. The  individuals  eligible to  participate in the Automatic
Option  Grant  Program  shall  be  (i)  those   individuals   who  first  become
non-employee  Board members after the Automatic  Option Grant Program  Effective
Date, whether through  appointment by the Board or election by the Corporation's
stockholders,  and (ii) those  individuals who continue to serve as non-employee
Board  members  after one or more Annual  Stockholders  Meetings  held after the
Automatic  Option Grant Program  Effective  Date,  including  those  individuals
serving as  non-employee  Board  members on the  Automatic  Option Grant Program
Effective  Date.  A  non-employee  Board member who has  previously  been in the
employ of the Corporation (or any Parent or Subsidiary) shall not be eligible to
receive an initial option grant under the Automatic  Option Grant Program at the
time he or she first becomes a non-employee  Board member,  but such  individual
shall be eligible to receive  periodic option grants under the Automatic  Option
Grant Program upon his or her continued  service as a non-employee  Board member
following one or more Annual Stockholders Meetings. However, in no event shall a
non-employee  Board  member be  eligible  to  receive  option  grants  under the
Automatic  Option Grant Program if such  individual is a 5%  Stockholder or is a
representative of, or affiliated with, a 5% Stockholder.


                                       3.



        V.        STOCK SUBJECT TO THE PLAN

                  A. The  stock  issuable  under  the Plan  shall be  shares  of
authorized but unissued or reacquired Common Stock, including shares repurchased
by the  Corporation  on the open market.  The maximum number of shares of Common
Stock which may be issued over the term of the Plan shall  initially  not exceed
950,000 shares.

                  B. The number of shares of Common Stock available for issuance
under the Plan shall  automatically  increase  on the first  trading day of each
calendar  year  during the term of the Plan,  beginning  with the 1997  calendar
year,  by an amount  equal to one  percent  (1%) of the  shares of Common  Stock
outstanding  on December  31 of the  immediately  preceding  calendar  year.  No
Incentive Options may be granted on the basis of the additional shares of Common
Stock resulting from such annual increases.

                  C. No one person participating in the Plan may receive options
and  separately  exercisable  stock  appreciation  rights for more than  100,000
shares of Common Stock in the aggregate per calendar  year,  beginning  with the
1995 calendar year; provided,  however, that for the calendar year in which such
person first commences Service, the limit shall be increased to 200,000 shares.

                  D. Shares of Common Stock subject to outstanding options shall
be  available  for  subsequent  issuance  under the Plan to the  extent  (i) the
options expire or terminate for any reason prior to exercise in full or (ii) the
options are cancelled in accordance with the cancellation-regrant  provisions of
Article Two. All shares  issued under the Plan,  whether or not those shares are
subsequently  repurchased by the Corporation  pursuant to its repurchase  rights
under the Plan, shall reduce on a share-for-share  basis the number of shares of
Common Stock  available  for  subsequent  issuance  under the Plan. In addition,
should the  exercise  price of an option  under the Plan be paid with  shares of
Common Stock or should shares of Common Stock otherwise  issuable under the Plan
be withheld by the Corporation in satisfaction of the withholding taxes incurred
in connection  with the exercise of an option under the Plan, then the number of
shares of Common Stock available for issuance under the Plan shall be reduced by
the gross number of shares for which the option is exercised, and not by the net
number of shares of Common Stock issued to the holder of such option.

                  E. Should any change be made to the Common  Stock by reason of
any stock  split,  stock  dividend,  recapitalization,  combination  of  shares,
exchange of shares or other change  affecting the outstanding  Common Stock as a
class  without  the   Corporation's   receipt  of   consideration,   appropriate
adjustments  shall be made to (i) the maximum  number and/or class of securities
issuable under the Plan,  (ii) the maximum number and/or class of securities for
which the share reserve is to increase automatically each year, (iii) the number
and/or class of securities  for which any one person may be granted  options and
separately  exercisable  stock  appreciation  rights per calendar year, (iv) the
number and/or class of securities  for which  automatic  option grants are to be
made subsequently per

                                       4.



Eligible  Director  under the Automatic  Option Grant Program and (v) the number
and/or class of securities and the exercise price per share in effect under each
outstanding  option in order to prevent the dilution or  enlargement of benefits
thereunder. The adjustments determined by the Plan Administrator shall be final,
binding and conclusive, absent manifest error.

                                       5.



                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM


I.       OPTION TERMS

                  Each option shall be evidenced by one or more documents in the
form  approved  by the Plan  Administrator;  provided,  however,  that each such
document shall comply with the terms specified below.  Each document  evidencing
an Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

                  A.       Exercise Price.

                           1. The exercise price per share shall be fixed by the
Plan  Administrator  and may be less  than,  equal to or  greater  than the Fair
Market Value per share of Common Stock on the option grant date.

                           2. The exercise  price shall become  immediately  due
upon exercise of the option and shall, subject to the provisions of Section I of
Article  Four and the  documents  evidencing  the option,  be payable in cash or
check made  payable to the  Corporation.  After the Section  12(g)  Registration
Date, the exercise price may also be paid as follows:

                                  (i) in  shares of  Common  Stock  held for the
         requisite  period  necessary  to  avoid a charge  to the  Corporation's
         earnings  for  financial  reporting  purposes and valued at Fair Market
         Value on the Exercise Date, or

                                  (ii) to the extent the option is exercised for
         vested shares, through a special sale and remittance procedure pursuant
         to which the Optionee shall concurrently  provide  irrevocable  written
         instructions to (a) a  Corporation-designated  brokerage firm to effect
         the  immediate   sale  of  the  purchased   shares  and  remit  to  the
         Corporation, out of the sale proceeds available on the settlement date,
         sufficient funds to cover the aggregate  exercise price payable for the
         purchased  shares plus all applicable  Federal,  state and local income
         and  employment  taxes  required to be withheld by the  Corporation  by
         reason  of such  exercise  and  (b)  the  Corporation  to  deliver  the
         certificates  for the purchased  shares directly to such brokerage firm
         in order to complete the sale.

                  Except to the extent  such sale and  remittance  procedure  is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.


                                       6.



                  B.  Exercise  and  Term  of  Options.  Each  option  shall  be
exercisable  at such time or times,  during  such  period and for such number of
shares as shall be  determined  by the Plan  Administrator  and set forth in the
documents evidencing the option.  However, no option shall have a term in excess
of ten (10) years measured from the option grant date.

                  C.       Effect of Termination of Service.

                           1. The following provisions shall govern the exercise
of any  options  held by the  Optionee  at the time of  cessation  of Service or
death:

                                  (i) Any option  outstanding at the time of the
         Optionee's cessation of Service for any reason shall remain exercisable
         for such period of time  thereafter  as shall be determined by the Plan
         Administrator and set forth in the documents evidencing the option, but
         no such option shall be exercisable  after the expiration of the option
         term.

                                  (ii)  Any  option  exercisable  in whole or in
         part by the Optionee at the time of death may be exercised subsequently
         by the  personal  representative  of the  Optionee's  estate  or by the
         person or  persons to whom the option is  transferred  pursuant  to the
         Optionee's  will  or  in  accordance  with  the  laws  of  descent  and
         distribution.

                                  (iii)  During  the   applicable   post-Service
         exercise  period,  the option may not be exercised in the aggregate for
         more  than the  number  of  vested  shares  for  which  the  option  is
         exercisable  on the date of the Optionee's  cessation of Service.  Upon
         the expiration of the applicable  exercise  period or (if earlier) upon
         the expiration of the option term, the option shall terminate and cease
         to be  outstanding  for any vested  shares for which the option has not
         been  exercised.  However,  the  option  shall,  immediately  upon  the
         Optionee's cessation of Service,  terminate and cease to be outstanding
         to the extent the option is not otherwise at that time  exercisable for
         vested shares.

                                  (iv)   Should   the   Optionee's   Service  be
         terminated for  Misconduct,  then all  outstanding  options held by the
         Optionee shall terminate immediately and cease to be outstanding.

                                  (v) In the event of an Involuntary Termination
         following a Corporate Transaction,the provisions of Section III of this
         Article Two shall govern the period for which the  outstanding  options
         are to remain exercisable following the Optionee's cessation of Service
         and shall supersede any provisions to the contrary in this section.

                                       7.



                           2. The Plan Administrator  shall have the discretion,
exercisable  either at the time an option is  granted  or at any time  while the
option remains outstanding, to:

                                  (i)  extend  the  period of time for which the
         option is to remain exercisable  following the Optionee's  cessation of
         Service  from the period  otherwise  in effect for that  option to such
         greater   period  of  time  as  the  Plan   Administrator   shall  deem
         appropriate,  but in no event beyond the expiration of the option term,
         and/or

                                  (ii) permit the option to be exercised, during
         the applicable  post-Service  exercise period, not only with respect to
         the number of vested  shares of Common  Stock for which such  option is
         exercisable at the time of the Optionee's cessation of Service but also
         with  respect  to one or more  additional  installments  in  which  the
         Optionee would have vested under the option had the Optionee  continued
         in Service.

                  D. Stockholder  Rights.  The holder of an option shall have no
stockholder  rights with respect to the shares  subject to the option until such
person shall have  exercised  the option,  paid the exercise  price and become a
holder of record of the purchased shares.

                  E. Repurchase Rights.  The Plan  Administrator  shall have the
discretion to grant options which are  exercisable for unvested shares of Common
Stock. Should the Optionee cease Service while holding such unvested shares, the
Corporation  shall have the right to repurchase,  at the exercise price paid per
share, any or all of those unvested shares. The terms upon which such repurchase
right shall be exercisable  (including the period and procedure for exercise and
the appropriate  vesting schedule for the purchased shares) shall be established
by the  Plan  Administrator  and  set  forth  in the  document  evidencing  such
repurchase right.

                  F. First Refusal Rights.  Until the Section 12(g) Registration
Date, the Corporation  shall have the right of first refusal with respect to any
proposed sale or other disposition by the Optionee (or any successor in interest
by reason of  purchase,  gift or other  transfer)  of any shares of Common Stock
issued  under the Plan.  Such right of first  refusal  shall be  exercisable  in
accordance with the terms and conditions  established by the Plan  Administrator
and set forth in the agreement evidencing such right.

                  G. Limited  Transferability of Options. During the lifetime of
the Optionee, the option shall be exercisable only by the Optionee and shall not
be assignable or  transferable  other than by will or by the laws of descent and
distribution following the Optionee's death. However, a Non-Statutory Option may
be  assigned in whole or in part during the  Optionee's  lifetime in  accordance
with the terms of a Qualified Domestic Relations Order. The assigned portion may
only be exercised by the person or persons who acquire a proprietary interest in
the option pursuant to such Qualified Domestic Relations

                                       8.



Order.  The terms  applicable to the assigned portion shall be the same as those
in effect for the option  immediately  prior to such assignment and shall be set
forth in such  documents  issued to the assignee as the Plan  Administrator  may
deem appropriate.

       II.        INCENTIVE OPTIONS

                  The terms specified below shall be applicable to all Incentive
Options.  Except as  modified  by the  provisions  of this  Section  II, all the
provisions  of  Articles  One,  Two and Five shall be  applicable  to  Incentive
Options. Options which are specifically designated as Non-Statutory Options when
issued under the Plan shall not be subject to the terms of this Section II.

                  A.  Eligibility.  Incentive  Options  may only be  granted  to
Employees.

                  B. Exercise  Price.  The exercise price per share shall not be
less  than one  hundred  percent  (100%) of the Fair  Market  Value per share of
Common Stock on the option grant date.

                  C. Dollar  Limitation.  The aggregate Fair Market Value of the
shares of Common Stock  (determined as of the respective date or dates of grant)
for which one or more  options  granted to any  Employee  under the Plan (or any
other option plan of the  Corporation or any Parent or  Subsidiary)  may for the
first time become  exercisable as Incentive  Options during any one (1) calendar
year shall not exceed the sum of One Hundred Thousand Dollars ($100,000). To the
extent the Employee holds two (2) or more such options which become  exercisable
for the first time in the same calendar  year,  the foregoing  limitation on the
exercisability  of such  options as  Incentive  Options  shall be applied on the
basis of the order in which such options are granted.

                  D.  10%  Stockholder.  If any  Employee  to whom an  Incentive
Option is granted is a 10% Stockholder,  then the exercise price per share shall
not be less than one  hundred ten  percent  (110%) of the Fair Market  Value per
share of Common  Stock on the option  grant date,  and the option term shall not
exceed five (5) years measured from the option grant date.

      III.        CORPORATE TRANSACTION/CHANGE IN CONTROL

                  A. In the event of any Corporate Transaction, each outstanding
option  shall   automatically   accelerate  so  that  each  such  option  shall,
immediately  prior to the effective  date of the Corporate  Transaction,  become
fully  exercisable  for all of the shares of Common Stock at the time subject to
such option and may be exercised for any or all of those shares as  fully-vested
shares of Common Stock.  However,  an outstanding option shall not so accelerate
if and to the  extent:  (i) such  option is, in  connection  with the  Corporate
Transaction,  either to be  assumed  by the  successor  corporation  (or  parent
thereof) or to be replaced  with a comparable  option to purchase  shares of the
capital stock of the successor

                                       9.



corporation (or parent thereof),  (ii) such option is to be replaced with a cash
incentive  program  of the  successor  corporation  which  preserves  the spread
existing on the unvested option shares at the time of the Corporate  Transaction
and provides for subsequent  payout in accordance with the same vesting schedule
applicable to such option or (iii) the acceleration of such option is subject to
other  limitations  imposed by the Plan  Administrator at the time of the option
grant. The determination of option comparability under clause (i) above shall be
made by the Plan Administrator,  and its determination  shall be final,  binding
and conclusive, absent manifest error.

                  B. All  outstanding  repurchase  rights  shall also  terminate
automatically, and the shares of Common Stock subject to those terminated rights
shall  immediately  vest in full,  in the  event of any  Corporate  Transaction,
except to the  extent:  (i) those  repurchase  rights are to be  assigned to the
successor  corporation  (or parent  thereof) in connection  with such  Corporate
Transaction or (ii) such accelerated  vesting is precluded by other  limitations
imposed by the Plan Administrator at the time the repurchase right is issued.

                  C.  Immediately  following the  consummation  of the Corporate
Transaction,   all   outstanding   options  shall  terminate  and  cease  to  be
outstanding,  except to the extent  assumed  by the  successor  corporation  (or
parent thereof).

                  D. Each option which is assumed in connection with a Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate  adjustments  shall  also be made to (i) the  number  and  class  of
securities  available for issuance under the Plan following the  consummation of
such Corporate Transaction, (ii) the exercise price payable per share under each
outstanding  option,  provided the  aggregate  exercise  price  payable for such
securities  shall  remain the same and (iii) the  maximum  number of  securities
and/or class of securities  for which any one person may be granted  options and
separately  exercisable  stock  appreciation  rights under the Plan per calendar
year.

                  E. Any options  which are assumed or replaced in the Corporate
Transaction and do not otherwise  accelerate at that time,  shall  automatically
accelerate (and any of the Corporation's  outstanding repurchase rights which do
not  otherwise  terminate  at  the  time  of  the  Corporate  Transaction  shall
automatically  terminate  and the  shares  of  Common  Stock  subject  to  those
terminated  rights shall  immediately  vest in full) in the event the Optionee's
Service should  subsequently  terminate by reason of an Involuntary  Termination
within  eighteen  (18) months  following the  effective  date of such  Corporate
Transaction.   Any  options  so  accelerated   shall  remain   exercisable   for
fully-vested  shares until the earlier of (i) the  expiration of the option term
or (ii) the  expiration of the one (1)- year period  measured from the effective
date of the Involuntary Termination.


                                       10.



                  F. The Plan  Administrator  shall have the discretion to grant
options  with  terms  different  from those  described  in this  Section  III in
connection with a Corporate Transaction.

                  G.  The  Plan   Administrator   shall  have  the   discretion,
exercisable  either at the time the  option is  granted or at any time while the
option remains outstanding, to (i) provide for the automatic acceleration of one
or more  outstanding  options  (and  the  automatic  termination  of one or more
outstanding repurchase rights with the immediate vesting of the shares of Common
Stock  subject to those  rights) upon the  occurrence  of a Change in Control or
(ii)  condition  any  such  option  acceleration  (and  the  termination  of any
outstanding  repurchase rights) upon the subsequent  Involuntary  Termination of
the Optionee's Service within a specified period following the effective date of
such Change in Control.  Any options  accelerated in connection with a Change in
Control  shall  remain  fully   exercisable   until  the  expiration  or  sooner
termination of the option term.

                  H.  The  portion  of  any  Incentive  Option   accelerated  in
connection  with a  Corporate  Transaction  or Change in  Control  shall  remain
exercisable as an Incentive Option only to the extent the applicable One Hundred
Thousand Dollar ($100,000) limitation is not exceeded. To the extent such dollar
limitation  is  exceeded,  the  accelerated  portion  of such  option  shall  be
exercisable as a Non-Statutory Option under the Federal tax laws.

                  I. The grant of options under the  Discretionary  Option Grant
Program  shall  in no way  affect  the  right  of  the  Corporation  to  adjust,
reclassify,  reorganize or otherwise change its capital or business structure or
to merge, consolidate,  dissolve,  liquidate or sell or transfer all or any part
of its business or assets.

       IV.        CANCELLATION AND REGRANT OF OPTIONS

                  The Plan Administrator  shall have the authority to effect, at
any time and from time to time, with the consent of the affected option holders,
the  cancellation  of any or all  outstanding  options  under the  Discretionary
Option Grant Program and to grant in substitution  new options covering the same
or  different  number of shares of Common  Stock but with an exercise  price per
share based on the Fair Market Value per share of Common Stock on the new option
grant date.

        V.        STOCK APPRECIATION RIGHTS

                  A. The Plan Administrator  shall have full power and authority
to grant to selected Optionees tandem stock  appreciation  rights and/or limited
stock appreciation rights.

                  B. The following  terms shall govern the grant and exercise of
tandem stock appreciation rights:


                                       11.



                                  (i) One or more  Optionees  may be granted the
         right,  exercisable  upon  such  terms  as the Plan  Administrator  may
         establish,  to elect between the exercise of the underlying  option for
         shares of Common Stock and the surrender of that option in exchange for
         a distribution from the Corporation in an amount equal to the excess of
         (a) the Fair Market Value (on the option  surrender date) of the number
         of  shares  in which  the  Optionee  is at the time  vested  under  the
         surrendered  option  (or  surrendered  portion  thereof)  over  (b) the
         aggregate exercise price payable for such shares.

                                  (ii)  No  such  option   surrender   shall  be
         effective  unless  it is  approved  by the Plan  Administrator.  If the
         surrender is so approved,  then the  distribution to which the Optionee
         shall be entitled  may be made in shares of Common Stock valued at Fair
         Market Value on the option surrender date, in cash, or partly in shares
         and  partly  in  cash,  as the  Plan  Administrator  shall  in its sole
         discretion deem appropriate.

                                  (iii)  If  the   surrender  of  an  option  is
         rejected by the Plan  Administrator,  then the  Optionee  shall  retain
         whatever  rights  the  Optionee  had under the  surrendered  option (or
         surrendered  portion  thereof)  on the  option  surrender  date and may
         exercise  such  rights  at any time  prior to the later of (a) five (5)
         business days after the receipt of the rejection notice or (b) the last
         day on which the option is otherwise exercisable in accordance with the
         terms of the documents evidencing such option, but in no event may such
         rights be  exercised  more than ten (10) years  after the option  grant
         date.

                  C. The following  terms shall govern the grant and exercise of
limited stock appreciation rights:

                                  (i) One or more  Section  16  Insiders  may be
         granted  limited  stock  appreciation  rights  with  respect  to  their
         outstanding options.

                                  (ii)   Upon  the   occurrence   of  a  Hostile
         Take-Over, each such individual holding one or more options with such a
         limited stock  appreciation right in effect for at least six (6) months
         shall have the unconditional  right  (exercisable for a thirty (30)-day
         period following such Hostile  Take-Over) to surrender each such option
         to the Corporation, to the extent the option is at the time exercisable
         for  vested  shares of Common  Stock.  In  return  for the  surrendered
         option,  the  Optionee  shall  receive  a cash  distribution  from  the
         Corporation in an amount equal to the excess of (a) the Take-Over Price
         of the shares of Common  Stock which are at the time vested  under each
         surrendered  option  (or  surrendered  portion  thereof)  over  (b) the
         aggregate   exercise   price   payable  for  such  shares.   Such  cash
         distribution  shall be paid within five (5) days  following  the option
         surrender date.

                                       12.



                                  (iii)   Neither  the   approval  of  the  Plan
         Administrator  nor the  consent  of the  Board  shall  be  required  in
         connection with such option surrender and cash distribution.

                                  (iv) The  balance of the option (if any) shall
         continue  in full force and  effect in  accordance  with the  documents
         evidencing such option.


                                       13.



                                  ARTICLE THREE

                         AUTOMATIC OPTION GRANT PROGRAM


        I.        OPTION TERMS

                  A.  Grant  Dates.  Option  grants  shall be made on the  dates
specified below:

                           1. Each  Eligible  Director  who is first  elected or
appointed  as a  non-employee  Board  member  after the  Automatic  Option Grant
Program  Effective  Date shall  automatically  be  granted,  on the date of such
initial election or appointment (as the case may be), a Non-Statutory  Option to
purchase 10,000 shares of Common Stock.

                           2. On the date of each  Annual  Stockholders  Meeting
held after the Automatic  Option Grant Program  Effective  Date, each individual
who is to continue to serve as an Eligible  Director  after such meeting,  shall
automatically  be  granted,  whether  or not such  individual  is  standing  for
re-election as a Board member at that Annual Meeting, a Non-Statutory  Option to
purchase an additional  2,000 shares of Common Stock,  provided such  individual
has served as a  non-employee  Board  member for at least six (6) months.  There
shall  be no limit on the  number  of such  2,000-share  option  grants  any one
Eligible Director may receive over his or her period of Board service.

                  B.       Exercise Price.

                           1. The exercise price per share shall be equal to one
hundred percent (100%) of the Fair Market Value per share of Common Stock on the
option grant date.

                           2. The exercise price shall be payable in one or more
of the  alternative  forms  authorized  under  the  Discretionary  Option  Grant
Program.  Except  to the  extent  the sale and  remittance  procedure  specified
thereunder is utilized,  payment of the exercise price for the purchased  shares
must be made on the Exercise Date.

                  C.  Option  Term.  Each  option  shall have a term of ten (10)
years measured from the option grant date.

                  D.  Exercise  and  Vesting of Options.  Each  option  shall be
immediately exercisable for any or all of the option shares. However, any shares
purchased under the option shall be subject to repurchase by the Corporation, at
the  exercise  price  paid per share,  upon the  Optionee's  cessation  of Board
service prior to vesting in those shares. Each initial grant shall vest, and the
Corporation's repurchase right shall lapse, in a series of three

                                       14.



(3)  successive  and equal annual  installments  over the  Optionee's  period of
continued  service as a Board member,  with the first such  installment  to vest
upon the  Optionee's  completion of one (1) year of Board service  measured from
the option  grant date.  Each annual  grant  shall vest,  and the  Corporation's
repurchase right shall lapse, upon the Optionee's  completion of one (1) year of
Board service measured from the option grant date.

                  E.  Effect of  Termination  of Board  Service.  The  following
provisions  shall govern the exercise of any options held by the Optionee at the
time the Optionee ceases to serve as a Board member:

                                  (i)  The   Optionee   (or,  in  the  event  of
         Optionee's death, the personal  representative of the Optionee's estate
         or the person or persons to whom the option is transferred  pursuant to
         the  Optionee's  will or in  accordance  with the laws of  descent  and
         distribution) shall have a twelve (12)- month period following the date
         of such  cessation  of Board  service  in which to  exercise  each such
         option.

                                  (ii)  During  the twelve  (12)-month  exercise
         period,  the option may not be exercised in the aggregate for more than
         the  number of vested  shares of Common  Stock for which the  option is
         exercisable at the time of the Optionee's cessation of Board service.

                                  (iii) Should the Optionee  cease to serve as a
         Board  member  by  reason of death or  Permanent  Disability,  then all
         shares at the time subject to the option shall immediately vest so that
         such option may, during the twelve (12)-month exercise period following
         such cessation of Board service, be exercised for all or any portion of
         those shares as fully-vested shares of Common Stock.

                           (iv) In no event shall the option remain  exercisable
         after the  expiration  of the option term.  Upon the  expiration of the
         twelve  (12)-month  exercise period or (if earlier) upon the expiration
         of the  option  term,  the  option  shall  terminate  and  cease  to be
         outstanding  for any  vested  shares  for which the option has not been
         exercised.  However, the option shall,  immediately upon the Optionee's
         cessation of Board service for any reason other than death or Permanent
         Disability,  terminate  and cease to be  outstanding  to the extent the
         option is not otherwise at that time exercisable for vested shares.


                                       15.



       II.        CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-
                  OVER

                  A. In the event of any  Corporate  Transaction,  the shares of
Common Stock at the time subject to each  outstanding  option but not  otherwise
vested  shall  automatically  vest  in  full so that  each  such  option  shall,
immediately  prior to the effective  date of the Corporate  Transaction,  become
fully  exercisable  for all of the shares of Common Stock at the time subject to
such  option and may be  exercised  for all or any  portion  of those  shares as
fully-vested shares of Common Stock.  Immediately  following the consummation of
the Corporate Transaction, each automatic option grant shall terminate and cease
to be outstanding, except to the extent assumed by the successor corporation (or
parent thereof).

                  B. In  connection  with any Change in  Control,  the shares of
Common Stock at the time subject to each  outstanding  option but not  otherwise
vested  shall  automatically  vest  in  full so that  each  such  option  shall,
immediately  prior to the effective date of the Change in Control,  become fully
exercisable  for all of the shares of Common  Stock at the time  subject to such
option  and  may  be  exercised  for  all or  any  portion  of  such  shares  as
fully-vested  shares of Common Stock. Each such option shall remain  exercisable
for such fully-vested  option shares until the expiration or sooner  termination
of the option term or the surrender of the option in  connection  with a Hostile
Take-Over.

                  C. Upon the  occurrence of a Hostile  Take-Over,  the Optionee
shall have a thirty  (30)-day  period in which to surrender  to the  Corporation
each  automatic  option  held by him or her for a  period  of at  least  six (6)
months. The Optionee shall in return be entitled to a cash distribution from the
Corporation  in an amount equal to the excess of (i) the Take-Over  Price of the
shares of Common Stock at the time subject to the surrendered option (whether or
not the Optionee is otherwise at the time vested in those  shares) over (ii) the
aggregate  exercise price payable for such shares.  Such cash distribution shall
be paid  within  five (5) days  following  the  surrender  of the  option to the
Corporation. No approval or consent of the Board or any Plan Administrator shall
be required in connection with such option surrender and cash distribution.

                  D. Each option which is assumed in connection with a Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate  adjustments  shall also be made to the exercise  price  payable per
share under each  outstanding  option,  provided the  aggregate  exercise  price
payable for such securities shall remain the same.

                  E. The grant of  options  under  the  Automatic  Option  Grant
Program  shall  in no way  affect  the  right  of  the  Corporation  to  adjust,
reclassify,  reorganize or otherwise change its capital or business structure or
to merge, consolidate,  dissolve,  liquidate or sell or transfer all or any part
of its business or assets.

                                       16.



      III.        AMENDMENT OF THE AUTOMATIC OPTION GRANT PROGRAM

                  The  provisions  of  this  Automatic   Option  Grant  Program,
together with the option grants  outstanding  thereunder,  may not be amended at
intervals  more  frequently  than once every six (6)  months,  other than to the
extent  necessary  to  comply  with  applicable  Federal  income  tax  laws  and
regulations.

       IV.        REMAINING TERMS

                  The remaining terms of each option granted under the Automatic
Option Grant  Program shall be the same as the terms in effect for option grants
made under the Discretionary Option Grant Program.


                                       17.



                                  ARTICLE FOUR

                                  MISCELLANEOUS


        I.        FINANCING

                  A. The Plan  Administrator  may permit any Optionee to pay the
option exercise price under the Discretionary Option Grant Program by delivering
a  promissory  note payable in one or more  installments.  The terms of any such
promissory note  (including the interest rate and the terms of repayment)  shall
be  established by the Plan  Administrator  in its sole  discretion.  Promissory
notes may be authorized with or without  security or collateral.  In all events,
the maximum  credit  available to the Optionee may not exceed the sum of (i) the
aggregate  option exercise price payable for the purchased  shares plus (ii) any
Federal,  state and local income and  employment  tax liability  incurred by the
Optionee in connection with the option exercise.

                  B. The Plan  Administrator  may, in its discretion,  determine
that one or more such  promissory  notes shall be subject to  forgiveness by the
Corporation  in whole or in part upon such terms as the Plan  Administrator  may
deem appropriate.

       II.        TAX WITHHOLDING

                  A. The  Corporation's  obligation to deliver  shares of Common
Stock upon the exercise of options or stock  appreciation  rights under the Plan
shall be subject to the satisfaction of all applicable Federal,  state and local
income and employment tax withholding requirements.

                  B. The Plan Administrator may, in its discretion,  provide any
or all holders of  Non-Statutory  Options under the Plan (other than the options
granted under the Automatic  Option Grant  Program) with the right to use shares
of Common  Stock in  satisfaction  of all or part of the Taxes  incurred by such
holders in  connection  with the  exercise of their  options.  Such right may be
provided to any such holder in either or both of the following formats:

                                  (i) Stock  Withholding:  The  election to have
         the  Corporation  withhold,  from the shares of Common Stock  otherwise
         issuable upon the exercise of such  Non-Statutory  Option, a portion of
         those  shares  with  an  aggregate  Fair  Market  Value  equal  to  the
         percentage  of the Taxes (not to exceed  one  hundred  percent  (100%))
         designated by the holder.

                                  (ii) Stock  Delivery:  The election to deliver
         to the Corporation,  at the time the Non-Statutory Option is exercised,
         one or more

                                       18.



         shares of Common Stock  previously  acquired by such holder (other than
         in connection  with the option  exercise  triggering the Taxes) with an
         aggregate  Fair Market Value equal to the  percentage of the Taxes (not
         to exceed one hundred percent (100%)) designated by the holder.

      III.        EFFECTIVE DATE AND TERM OF THE PLAN

                  A.  The  Discretionary   Option  Grant  Program  shall  became
effective  on the Plan  Effective  Date and  options  may be  granted  under the
Discretionary  Option Grant Program at any time after the Plan  Effective  Date.
The Automatic  Option Grant  Program  became  effective on the Automatic  Option
Grant Program  Effective Date and option grants under the Automatic Option Grant
Program  may be made to the  Eligible  Directors  after such date.  However,  no
options  granted  under the Plan may be exercised  until the Plan is approved by
the  Corporation's  stockholders.  If such stockholder  approval is not obtained
within  twelve  (12)  months  after the Plan  Effective  Date,  then all options
previously  granted under this Plan shall terminate and cease to be outstanding,
and no further  options shall be granted and no shares shall be issued under the
Plan.

                  B. The Plan was  amended on June 9, 1995 to (i)  increase  the
total  number of shares of Common  Stock  available  for  issuance  from 650,000
shares to  950,000  shares and (ii) to  increase  the number of shares of Common
Stock subject to the options  granted  under the Automatic  Option Grant Program
upon the initial  election or  appointment  of an Eligible  Director  from 5,000
shares to 10,000 and to increase the number of shares of Common Stock subject to
the  annual  option  grants  thereunder  to be made on the  date of each  Annual
Stockholders  Meeting to  continuing  non-employee  Board  members from 1,000 to
2,000 shares.

                  C. The Plan shall  terminate upon the earliest of (i) June 30,
2005,  (ii) the date on which all shares  available for issuance  under the Plan
shall have been issued pursuant to the exercise of the options under the Plan or
(iii) the termination of all outstanding  options in connection with a Corporate
Transaction.  Upon such Plan termination, all outstanding options shall continue
to have force and effect in  accordance  with the  provisions  of the  documents
evidencing such options.

       IV.        AMENDMENT OF THE PLAN

                  A. The Board  shall  have  complete  and  exclusive  power and
authority to amend or modify the Plan in any or all  respects.  However,  (i) no
such amendment or modification shall adversely affect any rights and obligations
with  respect to options or stock  appreciation  rights at the time  outstanding
under the Plan unless the Optionee  consents to such amendment or  modification,
and (ii) any  amendment  made to the  Automatic  Option  Grant  Program  (or any
options  outstanding  thereunder) shall be in compliance with the limitations of
that  program.  In  addition,  the Board shall not,  without the approval of the
Corporation's stockholders, (i) materially increase the maximum number of shares
issuable

                                       19.



under the Plan,  the number of shares for which options may be granted under the
Automatic Option Grant Program or the maximum number of shares for which any one
person  may be granted  options or  separately  exercisable  stock  appreciation
rights in the aggregate per calendar year, except for permissible adjustments in
the  event  of  certain  changes  in  the  Corporation's  capitalization,   (ii)
materially modify the eligibility  requirements for Plan  participation or (iii)
materially increase the benefits accruing to Plan participants.

                  B.  Options to purchase  shares of Common Stock may be granted
under the Discretionary Option Grant Program that are in excess of the number of
shares then  available for issuance  under the Plan,  provided any excess shares
actually  issued under those programs are held in escrow until there is obtained
stockholder  approval  of an  amendment  sufficiently  increasing  the number of
shares  of  Common  Stock  available  for  issuance  under  the  Plan.  If  such
stockholder  approval is not obtained  within  twelve (12) months after the date
the first such excess grants are made, then (i) any unexercised  options granted
on the basis of such excess shares shall  terminate and cease to be  outstanding
and (ii) the  Corporation  shall  promptly  refund to the Optionees the exercise
price  paid for any  excess  shares  issued  under the Plan and held in  escrow,
together  with  interest (at the  applicable  Short Term  Federal  Rate) for the
period the shares  were held in  escrow,  and such  shares  shall  thereupon  be
automatically cancelled and cease to be outstanding.

        V.        USE OF PROCEEDS

                  Any cash proceeds received by the Corporation from the sale of
shares  of  Common  Stock  under the Plan  shall be used for  general  corporate
purposes.

       VI.        REGULATORY APPROVALS

                  A. The  implementation of the Plan, the granting of any option
or stock  appreciation  right  under the Plan and the  issuance of any shares of
Common Stock upon the exercise of any option or stock  appreciation  right shall
be  subject  to the  Corporation's  procurement  of all  approvals  and  permits
required  by  regulatory  authorities  having  jurisdiction  over the Plan,  the
options and stock appreciation  rights granted under it and the shares of Common
Stock issued pursuant to it.

                  B. No shares of Common  Stock or other  assets shall be issued
or  delivered  under the Plan unless and until there shall have been  compliance
with all applicable  requirements  of Federal and state  securities laws and all
applicable  listing  requirements  of any stock exchange (or the Nasdaq National
Market, if applicable) on which Common Stock is then listed for trading.

      VII.        NO EMPLOYMENT/SERVICE RIGHTS

                  Nothing in the Plan shall  confer upon the  Optionee any right
to continue in Service for any period of specific  duration or interfere with or
otherwise restrict in any way

                                       20.



the  rights  of the  Corporation  (or any  Parent  or  Subsidiary  employing  or
retaining  such person) or of the  Optionee,  which rights are hereby  expressly
reserved by each, to terminate such person's Service at any time for any reason,
with or without cause.

                                       21.



                                    APPENDIX


            The following definitions shall be in effect under the Plan:

         A. Automatic Option Grant Program shall mean the automatic option grant
program in effect under the Plan.

         B. Automatic Option Grant Program Effective Date shall mean the date on
which the  Underwriting  Agreement is executed and the initial  public  offering
price of the Common Stock is established.

         C. Board shall mean the Corporation's Board of Directors.

         D. Change in Control shall mean a change in ownership or control of the
Corporation effected through either of the following transactions:

                         (i) the  acquisition,  directly or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with, the  Corporation),  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's stockholders which
         the Board does not recommend such stockholders to accept, or

                        (ii) a change in the  composition  of the  Board  over a
         period  of  thirty-six  (36)  consecutive  months  or less  such that a
         majority  of the  Board  members  ceases,  by  reason  of  one or  more
         contested   elections  for  Board   membership,   to  be  comprised  of
         individuals who either (A) have been Board members  continuously  since
         the  beginning of such period or (B) have been elected or nominated for
         election as Board members  during such period by at least a majority of
         the Board  members  described in clause (A) who were still in office at
         the time the Board approved such election or nomination.

         E. Code shall mean the Internal Revenue Code of 1986, as amended.

         F. Common Stock shall mean the Corporation's common stock.

         G.   Corporate   Transaction   shall  mean  either  of  the   following
stockholder-approved transactions to which the Corporation is a party:


                                      A-1.



                        (i)  a  merger  or  consolidation  in  which  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities are transferred to a
         person or persons  different from the persons holding those  securities
         immediately prior to such transaction; or

                        (ii) the sale,  transfer or other  disposition of all or
         substantially all of the Corporation's  assets in complete  liquidation
         or dissolution of the Corporation.

         H. Corporation  shall mean Atlantic  Pharmaceuticals,  Inc., a Delaware
corporation,  and any  corporate  successor to all or  substantially  all of the
assets  or  voting  stock  of  Atlantic  Pharmaceuticals,  Inc.  which  shall by
appropriate action adopt the Plan.

         I.  Discretionary  Option Grant  Program  shall mean the  discretionary
option grant program in effect under the Plan.

         J. Domestic  Relations  Order shall mean any judgment,  decree or order
(including  approval  of a property  settlement  agreement)  which  provides  or
otherwise  conveys,   pursuant  to  applicable  State  domestic  relations  laws
(including  community  property laws),  marital property rights to any spouse or
former spouse of the Optionee.

         K. Eligible Director shall mean a non-employee Board member eligible to
participate  in the  Automatic  Option  Grant  Program  in  accordance  with the
eligibility provisions of Article One.

         L.  Employee  shall  mean an  individual  who is in the  employ  of the
Corporation (or any Parent or Subsidiary),  subject to the control and direction
of the employer  entity as to both the work to be  performed  and the manner and
method of performance.

         M.  Exercise  Date shall mean the date on which the  Corporation  shall
have received written notice of the option exercise.

         N. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

                         (i) If the  Common  Stock is at the time  traded on the
         Nasdaq National Market, then the Fair Market Value shall be the closing
         selling  price per share of Common  Stock on the date in  question,  as
         such  price is  reported  by the  National  Association  of  Securities
         Dealers on the Nasdaq National Market or any successor system. If there
         is no  closing  selling  price  for the  Common  Stock  on the  date in
         question, then the Fair Market Value shall be the closing selling price
         on the last preceding date for which such quotation exists.

                                      A-2.



                        (ii) If the  Common  Stock is at the time  traded on the
         Nasdaq SmallCap Market or the  over-the-counter  market,  then the Fair
         Market  Value shall be the average of the highest bid and lowest  asked
         prices per share of Common  Stock on the date in question on the Nasdaq
         SmallCap  Market or the  over-the-counter  market,  as such  prices are
         reported by the National  Association of Securities Dealers through its
         Nasdaq system or any successor system. If there are no reported bid and
         asked  prices for the Common  Stock on the date in  question,  then the
         Fair  Market  Value  shall be the average of the highest bid and lowest
         asked  prices  on the last  preceding  date for which  such  quotations
         exist.

                       (iii) If the  Common  Stock is at the time  listed on any
         Stock Exchange, then the Fair Market Value shall be the closing selling
         price per share of Common  Stock on the date in  question  on the Stock
         Exchange  determined by the Plan Administrator to be the primary market
         for the  Common  Stock,  as such  price  is  officially  quoted  in the
         composite tape of transactions on such exchange. If there is no closing
         selling  price for the Common Stock on the date in  question,  then the
         Fair  Market  Value  shall  be the  closing  selling  price on the last
         preceding date for which such quotation exists.

                        (iv) For purposes of any option  grants made on the date
         the Underwriting  Agreement is executed and the initial public offering
         price of the Common Stock is  established,  the Fair Market Value shall
         be deemed to be equal to the  established  initial  offering  price per
         share.  For purposes of option grants made prior to such date, the Fair
         Market Value shall be determined by the Plan Administrator after taking
         into  account  such  factors  as  the  Plan  Administrator  shall  deem
         appropriate.

         O. 5% Stockholder  shall mean the owner of stock (as  determined  under
Code  Section  424(d))  possessing  more  than  five  percent  (5%) of the total
combined  voting power of all classes of stock of the Corporation (or any Parent
or Subsidiary).

         P.  Hostile   Take-Over  shall  mean  a  change  in  ownership  of  the
Corporation effected through the following transaction:

                         (i) the  acquisition,  directly or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with,  the  Corporation)  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's

                                      A-3.



         stockholders  which the Board does not recommend such  stockholders  to
         accept, and

                        (ii) more than fifty percent (50%) of the  securities so
         acquired are accepted from persons other than Section 16 Insiders.

         Q.  Incentive   Option  shall  mean  an  option  which   satisfies  the
requirements of Code Section 422.

         R. Involuntary Termination shall mean the termination of the Service of
any individual which occurs by reason of:

                        (i) such individual's involuntary dismissal or discharge
         by the Corporation for reasons other than Misconduct, or

                        (ii) such individual's  voluntary  resignation following
         (A) a  change  in  his or  her  position  with  the  Corporation  which
         materially reduces his or her level of responsibility,  (B) a reduction
         in his or her level of  compensation  (including  base  salary,  fringe
         benefits  and  participation  in  corporate-performance  based bonus or
         incentive  programs)  by  more  than  fifteen  percent  (15%)  or (C) a
         relocation of such individual's  place of employment by more than fifty
         (50) miles,  provided and only if such change,  reduction or relocation
         is effected by the Corporation without the individual's consent.

         S.  Misconduct   shall  mean  the  commission  of  any  act  of  fraud,
embezzlement or dishonesty by the Optionee,  any  unauthorized use or disclosure
by such person of  confidential  information or trade secrets of the Corporation
(or any  Parent or  Subsidiary),  or any other  intentional  misconduct  by such
person  adversely  affecting the business or affairs of the  Corporation (or any
Parent or Subsidiary) in a material manner.  The foregoing  definition shall not
be deemed to be inclusive of all the acts or omissions which the Corporation (or
any Parent or Subsidiary) may consider as grounds for the dismissal or discharge
of any Optionee or other person in the Service of the Corporation (or any Parent
or Subsidiary).

         T. 1934 Act shall mean the Securities Exchange Act of 1934, as amended.

         U.  Non-Statutory  Option  shall mean an option not intended to satisfy
the requirements of Code Section 422.

         V.  Optionee  shall mean any person to whom an option is granted  under
the Discretionary Option Grant or Automatic Option Grant Program.


                                      A-4.



         W. Parent shall mean any corporation (other than the Corporation) in an
unbroken  chain of  corporations  ending  with the  Corporation,  provided  each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such  chain.  For  purposes of the grant of  Non-Statutory  Options and stock
appreciation  rights  under the  Discretionary  Option Grant  Program,  the term
Parent shall also include any corporation,  partnership,  joint venture or other
business  entity which,  directly or  indirectly,  controls the  management  and
policies of the Corporation, whether through the ownership of voting securities,
by contract or otherwise.

         X.  Permanent   Disability  or  Permanently  Disabled  shall  mean  the
inability  of the  Optionee  to engage in any  substantial  gainful  activity by
reason of any medically  determinable  physical or mental impairment expected to
result in death or to be of  continuous  duration of twelve (12) months or more.
However,  solely  for  the  purposes  of the  Automatic  Option  Grant  Program,
Permanent  Disability or  Permanently  Disabled  shall mean the inability of the
non-employee  Board  member to perform his or her usual duties as a Board member
by reason of any medically  determinable  physical or mental impairment expected
to result in death or to be of  continuous  duration  of twelve  (12)  months or
more.

         Y. Plan shall mean the  Corporation's  1995 Stock Option  Plan,  as set
forth in this document.

         Z. Plan  Administrator  shall mean the particular  entity,  whether the
Board, the Primary Committee or the Secondary Committee,  which is authorized to
administer  the  Discretionary  Option Grant Program with respect to one or more
classes of eligible  persons,  to the extent  such  entity is  carrying  out its
administrative  functions under those programs with respect to the persons under
its jurisdiction.

         AA.  Plan  Effective  Date  shall  mean the  date on which  the Plan is
adopted by the Board.

         AB. Primary  Committee shall mean the committee of two (2) or more non-
employee Board members  appointed by the Board to administer  the  Discretionary
Option Grant Program with respect to Section 16 Insiders.

         AC. Qualified  Domestic Relations Order shall mean a Domestic Relations
Order which substantially complies with the requirements of Code Section 414(p).
The Plan  Administrator  shall have the sole  discretion to determine  whether a
Domestic Relations Order is a Qualified Domestic Relations Order.

         AD. Secondary Committee shall mean a committee of two (2) or more Board
members  appointed by the Board to  administer  the  Discretionary  Option Grant
Program with respect to eligible persons other than Section 16 Insiders.

                                      A-5.



         AE.  Section 16  Insider  shall  mean an  officer  or  director  of the
Corporation  subject to the short-swing  profit liabilities of Section 16 of the
1934 Act.

         AF. Section 12(g)  Registration Date shall mean the first date on which
the Common Stock is registered under Section 12(g) of the 1934 Act.

         AG. Service shall mean the provision of services to the Corporation (or
any  Parent  or  Subsidiary)  by a person  in the  capacity  of an  Employee,  a
non-employee  member of the board of directors or a  consultant  or  independent
advisor,  except to the extent otherwise  specifically provided in the documents
evidencing the option grant.

         AH. Stock Exchange shall mean either the American Stock Exchange or the
New York Stock Exchange.

         AI. Subsidiary shall mean any corporation  (other than the Corporation)
in an unbroken chain of corporations  beginning with the  Corporation,  provided
each corporation  (other than the last  corporation) in the unbroken chain owns,
at the time of the  determination,  stock possessing fifty percent (50%) or more
of the total  combined  voting power of all classes of stock in one of the other
corporations in such chain. For purposes of the grant of  Non-Statutory  Options
and stock appreciation rights under the Discretionary  Option Grant Program, the
term Subsidiary shall also include any corporation,  partnership,  joint venture
or other  business  entity in which the  Corporation,  directly  or  indirectly,
controls the  management and policies,  whether  through the ownership of voting
securities, by contract or otherwise.

         AJ. Take-Over Price shall mean the greater of (i) the Fair Market Value
per  share  of  Common  Stock  on the  date the  option  is  surrendered  to the
Corporation in connection with a Hostile  Take-Over or (ii) the highest reported
price per share of Common  Stock paid by the tender  offeror in  effecting  such
Hostile  Take-Over.  However,  if the surrendered option is an Incentive Option,
the Take-Over Price shall not exceed the clause (i) price per share.

         AK. Taxes shall mean the Federal, state and local income and employment
tax  liabilities  incurred  by the holder of  Non-Statutory  Options or unvested
shares of Common Stock in  connection  with the exercise of those options or the
vesting of those shares.

         AL. 10% Stockholder  shall mean the owner of stock (as determined under
Code  Section  424(d))  possessing  more  than ten  percent  (10%) of the  total
combined  voting power of all classes of stock of the Corporation (or any Parent
or Subsidiary).

         AM.  Underwriting  Agreement  shall  mean  the  agreement  between  the
Corporation  and the  underwriter  or  underwriters  managing the initial public
offering of the Common Stock.

                                      A-6.