REVISED LEASE AMENDMENT #8 ORIGINAL LEASE DATE: September 10, 1991 LEASE AMENDMENT DATE: August 26, 1996 LANDLORD: SPIEKER-SINGLETON #68 LIMITED PARTNERSHIP A California Limited Partnership TENANT: SCICLONE PHARMACEUTICALS, INC A California Corporation Landlord and Tenant, by executing this Lease Amendment as provided do hereby amend the Original Lease referred to above as follows: 1. TERM 11/01/96 - 04/30/2000 2. PREMISES Effective November 1, 1996 approximately 1,155 square feet of rentable space on the second floor (Suite #265) of San Mateo BayCenter, Phase II, shall be incorporated into the Original Lease Agreement. Total square footage shall increase from 15,227 to 16,382 rentable square feet. 3. RENTAL AMOUNT DUE: Additional Existing 11/01/96 - 11/30/96 1,155 rsf. 15,227 rsf. 16,382 rsf. -------------------------------------------------------------------------------- Base Rent $1,686.00 $17,236.00 $18,922.00 Op. Exp. (est. '96) $693.00 $9,137.00 $9,830.00 ------- --------- --------- Total Rent $2,379.00 $26,373.00 $28,752.00 Additional Existing 12/01/96 - 12/31/96 1,155 rsf. 15,227 rsf. 16,382 rsf. ------------------------------------------------------------------------------- Base Rent $1,496.26 $17,236.00 $18,732.26 Op. Exp. (est. '96) $693.00 $ 9,137.00 $ 9,830.00 ------- ---------- ---------- Total Rent $2,189.26 $26,373.00 $28,562.26 Additional Existing 01/01/97 - 04/30/97 1,155 rsf. 15,227 rsf. 16.382 rsf. ------------------------------------------------------------------------------- Base Rent $1,340.00 $17,354.00 $18,694.00 Op. Exp. (est. '96) $693.00 $9,137.00 $9,830.00 ------- --------- --------- Total Rent $2,033.00 $26,491.00 $28,524.00 Additional Existing 05/01/97 - 12/31/97 1,155 rsf. 15,227 rsf. 16,382 rsf. ------------------------------------------------------------------------------ Base Rent $1,397.00 $18,018.00 $19,415.00 Op. Exp. (est. '96) $693.00 $9,137.00 $9,830.00 ------- --------- --------- Total Rent $2,090.00 $27,155.00 $29,245.00 SciCione Phanylaccuticals, Inc. Lease Amendment #8 8/26/96 Page 2 Additional Existing 01/01/98 - 04/30/98 1,155 rsf. 15,227 rsf. 16,382 rsf. ---------------------------------------------------------------------------------- Base Rent $1,397.00 $18,136.00 $19,533.00 Op. Exp. (est. '96) $693.00 $9,137.00 $9,830.00 ------- --------- --------- Total Rent $2,090.00 $27,273.00 $29,363.00 Additional Existing 05/01/98 - 12/31/98 1,155 rsf. 15,227 rsf. 16.382 rsf. -------------------------------------------------------------------------------- Base Rent $1,455.00 $18,799.00 $20,254.00 Op. Exp. (est. '96) $693.00 $ 9,137.00 $9,830.00 ------- ---------- --------- Total Rent $2,148.00 $27,936.00 $30,084.00 Additional Existing 01/01/99 - 04/30/99 1,155 rsf. 15,227 rsf. 16.382 rsf. --------------------------------------------------------------------------------- Base Rent $1,455.00 $18,937.00 $20,392.00 Op. Exp. (est. '96) $693.00 $ 9,137,00 $9,830.00 ------- ---------- --------- Total Rent $2,148.00 $28,074.00 $30,222.00 Additional Existing 05/01/99 - 04/30/2000 1,155 rsf. 15,227 rsf. 16,382 rsf. --------------------------------------------------------------------------------- Base Rent $1,513.00 $19,600.00 $21,113.00 Op. Exp. (est. '96) $693.00 $9,137.00 $9,830.00 ------- --------- --------- Total Rent $2,206.00 $28,737.00 $30,943.00 4. TENANT PROPORTIONATE SHARE Effective November 1, 1996, Tenant's proportionate share shall increase from 12.79% to 13.76%. All other terms and conditions of the original Lease Agreement and Lease Amendaments #1 through #7 shall apply to this Lease Amendment #8, as agreed to this 26th day of August, 1996. LANDLORD: SPIEKER-SINGLETON #68 LIMITED PARTERSHIP A California Limited Partnership By: Peter H. Schnugg Its: Agent for Owner Date: 8/26/96 TENANT: SCICLONE PHARMACEUTICALS, INC. A California Corporation By: Mark A. Culhane Its: Vice President Finance & Administration, CFO Date: August 26, 1996