SCHEDULE 14A INFORMATION
                PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                         SECURITIES EXCHANGE ACT OF 1934
                         (Amendment No. ______________)


Filed by the Registrant    /X/
Filed by a party other than the Registrant   / /

Check the appropriate box:
/ /  Preliminary proxy statement
/ /  Confidential, for use of the Commission only (as permitted by
     Rule 14a-6(e)(2))
/X/  Definitive proxy statement
/ /  Definitive additional materials
/ /  Soliciting material pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                         CELTRIX PHARMACEUTICALS, INC.
            ------------------------------------------------
            (Name of Registrant as Specified in Its Charter)

                         CELTRIX PHARMACEUTICALS, INC.
  ------------------------------------------------------------------------
  (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

/X/  No fee required.


/ /  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

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(2)  Aggregate number of securities to which transactions applies:

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(3)  Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
fee is calculated and state how it was determined):

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(4)  Proposed maximum aggregate value of transaction:

- ----------------------------------------------------------------------------

(5)  Total fee paid:

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/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously.  Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

(1)  Amount previously paid:

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(2)  Form, Schedule or Registration Statement No.:

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(3)  Filing party:

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(4)  Date filed:

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                          CELTRIX PHARMACEUTICALS, INC.
                               ------------------

                    Notice of Annual Meeting of Stockholders
                          To Be Held September 9, 1997

TO THE STOCKHOLDERS:

     NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders  of Celtrix
Pharmaceuticals,  Inc. (the "Company"), a Delaware corporation,  will be held at
the Company's principal executive offices,  located at 3055 Patrick Henry Drive,
Santa Clara,  California,  on Tuesday,  September 9, 1997,  at 10:00 a.m.  local
time, for the following purposes:

     1.  To elect  directors  to serve  for the  ensuing  year and  until  their
         successors are elected.

     2.  To approve an  amendment  to the 1991 Stock Option Plan to increase the
         number of shares of Common Stock  reserved for issuance  thereunder  by
         1,500,000  shares and to permit  nonemployee  members of the  Company's
         Board of Directors to be eligible to receive  stock option grants under
         the 1991 Stock Option Plan.

     3.  To ratify the appointment of Ernst & Young LLP as independent  auditors
         of the Company for the fiscal year ending March 31, 1998.

     4.  To transact such other business as may properly come before the meeting
         and any adjournment(s) thereof.

     The  foregoing  items of  business  are more fully  described  in the Proxy
Statement accompanying this Notice.

     Only  stockholders  of record at the close of business on July 15, 1997 are
entitled to notice of and to vote at the Annual  Meeting and any  adjournment(s)
thereof.

     All  stockholders  are  cordially  invited to attend the Annual  Meeting in
person.  However, to assure your representation at the meeting, you are urged to
mark,  sign,  date and return the enclosed proxy card as promptly as possible in
the envelope  enclosed for that purpose.  Any stockholder  attending the meeting
may vote in person even if such stockholder returned a proxy card.

                                     FOR THE BOARD OF DIRECTORS

                                     CRAIG W. JOHNSON, Secretary

Santa Clara, California
July 21, 1997

- --------------------------------------------------------------------------------
                             YOUR VOTE IS IMPORTANT
In order to assure your  representation  at the  meeting,  you are  requested to
complete,  sign and date the  enclosed  proxy card as promptly  as possible  and
return it in the envelope provided.
- --------------------------------------------------------------------------------





                          CELTRIX PHARMACEUTICALS, INC.
                                ----------------

                         PROXY STATEMENT FOR 1997 ANNUAL
                             MEETING OF STOCKHOLDERS


                 INFORMATION CONCERNING SOLICITATION AND VOTING

General

     The  enclosed  Proxy is  solicited  on behalf of the Board of  Directors of
Celtrix   Pharmaceuticals,   Inc.  ("Celtrix"  or  the  "Company"),  a  Delaware
corporation,  for use at the Annual Meeting of Stockholders scheduled to be held
September 9, 1997, at 10:00 a.m. local time, or at any  adjournment(s)  thereof,
for the  purposes  set forth in this  Proxy  Statement  and in the  accompanying
Notice of Annual Meeting of Stockholders. The Annual Meeting will be held at the
Company's  principal  executive  offices,  located at 3055 Patrick  Henry Drive,
Santa Clara,  California  95054-1815.  The  Company's  telephone  number at that
location is (408) 988-2500.

     These proxy solicitation materials were mailed on or about July 21, 1997 to
all stockholders entitled to vote at the meeting.

Revocability of Proxies

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time before its use by  delivering  to the Company  (Attention:
Chief Financial Officer) a written notice of revocation or a duly executed proxy
bearing a later date, or by attending the meeting and voting in person.

Voting and Solicitation

     Every  stockholder  voting for the election of directors  may cumulate such
stockholder's votes and give one candidate a number of votes equal to the number
of  directors  to be elected  multiplied  by the  number of shares  held by such
stockholder,  or distribute the stockholder's  votes on the same principle among
as many candidates as the stockholder  thinks fit, provided that votes cannot be
cast for more than three candidates.  However,  no stockholder shall be entitled
to cumulate  votes  unless the  candidate's  name has been placed in  nomination
prior to the voting and the  stockholder,  or any other  stockholder,  has given
notice at the  meeting  prior to the voting of the  intention  to  cumulate  the
stockholder's votes. On all other matters, each share has one vote.

     Votes cast by proxy or in person at the Annual Meeting will be tabulated by
the  Inspector  of  Elections  (the  "Inspector")  with  the  assistance  of the
Company's  transfer  agent.  The Inspector will also determine  whether or not a
quorum is  present.  Except with  respect to the  election  of  directors  where
cumulative voting is invoked and except in certain other specific circumstances,

                                      -1-



the affirmative vote of a majority of shares present in person or represented by
proxy at a duly held  meeting  at which a quorum is present  is  required  under
Delaware law for approval of proposals  presented to  stockholders.  In general,
Delaware law also  provides  that a quorum  consists of a majority of the shares
entitled to vote and present in person or  represented  by proxy.  The Inspector
will treat  abstentions  as shares  that are  present  and  entitled to vote for
purposes of  determining  the  presence  of a quorum and as  negative  votes for
purposes of determining the approval of any matter submitted to the stockholders
for a vote.  Any proxy which is returned  using the form of proxy  enclosed  and
which is not marked as to a  particular  item will be voted for the  election of
directors,  for approval of the  amendment  to the 1991 Stock  Option Plan,  for
ratification of the appointment of the designated  independent  auditors and, as
the proxy  holders  deem  advisable,  on other  matters that may come before the
meeting,  as the case may be with  respect to the item not  marked.  If a broker
indicates  on the  enclosed  proxy  or its  substitute  that  it does  not  have
discretionary  authority  as to certain  shares to vote on a  particular  matter
("broker  non-votes"),  those  shares  will not be  considered  as present  with
respect to that matter.  The Company believes that the tabulation  procedures to
be  followed  by  the  Inspector  are  consistent  with  the  general  statutory
requirements  in Delaware  concerning  voting of shares and  determination  of a
quorum.

     The cost of  soliciting  proxies will be borne by the Company.  The Company
may reimburse brokerage firms and other persons  representing  beneficial owners
of shares  for their  expenses  in  forwarding  solicitation  materials  to such
beneficial  owners.  Proxies may also be solicited  by certain of the  Company's
directors,  officers and employees, without additional compensation,  personally
or by telephone or telegram.

Record Date and Share Ownership

     Only  stockholders  of record at the close of business on July 15, 1997 are
entitled  to  notice  of and to  vote  at the  meeting.  As of  July  15,  1997,
20,985,305  shares of the Company's Common Stock, $.01 par value per share, were
issued and outstanding.


                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS

Nominees

     At the Annual Meeting, three directors are to be elected to serve until the
next Annual Meeting and until their successors are elected and qualified. Unless
otherwise  instructed,  the proxy holders will vote the proxies received by them
for  the  Company's  three  nominees  named  below,  all of whom  are  currently
directors of the Company. In the event that any nominee of the Company is unable
or  declines  to serve as a  director  at the time of the  Annual  Meeting,  the
proxies  will be voted for any  nominee who shall be  designated  by the present
Board of Directors to fill the vacancy. In the event that additional persons are
nominated  for  election  as  directors,  the proxy  holders  intend to vote all
proxies  received by them in such a manner in accordance with cumulative  voting
as will assure the election of as many of the nominees listed below as possible,

                                      -2-



and, in such event, the specific  nominees to be voted for will be determined by
the proxy  holders.  It is not  expected  that any nominee  listed below will be
unable or will decline to serve as a director. Assuming a quorum is present, the
three nominees for director  receiving the greatest  number of votes cast at the
Annual  Meeting will be elected.  The term of office of each person elected as a
director will continue  until the next Annual Meeting of  Stockholders  or until
his successor has been elected and qualified.


     The  nominees'  names,  ages as of July 15, 1997,  and certain  information
about them are set forth below:


                                                                                                        Director
       Name of  Nominee                         Age        Principal Occupation                          Since
       ----------------                         ---        --------------------                         --------
                                                                                                  
Henry E. Blair............................      53     Chairman and Chief Executive Officer of Dyax       1995
                                                       Corporation; Co-Founder and Consultant,
                                                       Genzyme Corporation and Director of the
                                                       Company


Andreas Sommer, Ph.D......................      55     Chief Executive Officer, President and             1994
                                                       Director of the Company


James E. Thomas...........................      37     Chairman of the Board of Directors of the          1993
                                                       Company; Managing Director of E.M. Warburg,
                                                       Pincus & Co., Inc.


     Except as set forth  below,  each of the  nominees  has been engaged in the
principal  occupation  set forth  next to his name  above  during  the past five
years.  There  are no family  relationships  among the  directors  or  executive
officers of the Company.

     Mr. Blair was elected to the Board of Directors of Celtrix in January 1995.
He was a  co-founder  of Genzyme  Corporation  in 1981 and  served as  Genzyme's
Senior Vice President,  Manufacturing,  Research and Development  until 1988. He
continues to serve on Genzyme's  Board of Directors and as a  consultant.  Since
April 1997, Mr. Blair has served as Chairman and Chief Executive Officer of Dyax
Corporation.  Mr. Blair is also a director of Genzyme Transgenic Corporation and
several privately-held companies.

     Dr. Sommer was appointed Chief  Executive  Officer and President of Celtrix
in  April  1995  and has  served  as a  director  of  Celtrix  since  May  1994.
Previously,  Dr.  Sommer  served as Senior Vice  President of Celtrix since July
1993 and as Vice President, Research of Celtrix since 1992, following the merger
with BioGrowth, Inc. ("BioGrowth"). From 1989 to 1991, Dr. Sommer served as Vice
President, Research and Development of BioGrowth.

     Mr.  Thomas was elected  Chairman of the Board of Celtrix in April 1995 and
has served as a director of Celtrix since  November 1993. He has been a Managing
Director of E.M.  Warburg,  Pincus & Co.,  Inc.  since January 1994 and has held
various other positions at Warburg since

                                      -3-



1989. He is also a director of Anergen, Inc., Menley & James Laboratories, Inc.,
Transkaryotic  Therapies,  Inc.,  Xomed  Surgical  Products,  Inc.  and  several
privately-held companies.

Board of Directors Meetings and Committees

     The Board of Directors  of the Company held a total of six meetings  during
the year ended March 31, 1997. The Board of Directors has an Audit Committee and
a Compensation Committee. It does not have a nominating committee or a committee
performing the functions of a nominating committee.

     The  Audit  Committee  of the  Board of  Directors  currently  consists  of
directors  Blair and  Thomas,  the  chairman of the Audit  Committee.  The Audit
Committee held one meeting during fiscal 1997.  The Audit  Committee  recommends
engagement of the Company's independent  auditors,  and is primarily responsible
for approving the services performed by the Company's  independent  auditors and
for reviewing and evaluating the Company's accounting  principles and its system
of internal accounting controls.

     The Compensation  Committee of the Board of Directors currently consists of
directors  Thomas and Blair,  the chairman of the  Compensation  Committee.  Dr.
Sommer serves as an ex officio  member.  The  Compensation  Committee  held four
meetings  during fiscal 1997.  The  Compensation  Committee is  responsible  for
setting and administering the policies for executive compensation and short-term
and long-term incentive programs.

     In fiscal  1997,  no  incumbent  director  attended  fewer  than 75% of the
aggregate  number of  meetings  of the Board of  Directors  and  meetings of the
committees of the Board of Directors on which he serves.

Compensation of Directors

     Directors are reimbursed for out-of-pocket  travel expenses associated with
their attendance at Board meetings. Independent non-employee directors receive a
fee of $1,000 for each meeting of the Board of Directors  attended.  Independent
non-employee  directors participate in the Company's 1991 Directors' Option Plan
(the  "Directors'  Plan"),  pursuant to which such  directors are  automatically
granted  options to purchase  shares of Common Stock of the Company on the terms
and conditions set forth in the Directors' Plan. During the year ended March 31,
1997,  director  Blair was granted an option to purchase  3,333 shares of Common
Stock of the Company at an exercise price of $2.313 per share.

     THE BOARD OF DIRECTORS  RECOMMENDS  A VOTE FOR ALL OF THE  NOMINEES  LISTED
ABOVE.

                                      -4-




                                 PROPOSAL NO. 2
                     AMENDMENT TO THE 1991 STOCK OPTION PLAN

     At the Annual Meeting, stockholders are being asked to approve an amendment
to the 1991 Stock  Option Plan (the  "Option  Plan"),  to increase the number of
shares of Common Stock reserved for issuance thereunder by 1,500,000 shares to a
total of  3,000,000  reserved  shares and to permit  nonemployee  members of the
Company's Board of Directors to be eligible to receive stock option grants under
the Option Plan.  The Board of Directors  adopted this  amendment in April 1997,
subject to stockholder  approval.  The Board of Directors believes that in order
to attract,  motivate and retain highly qualified  employees and consultants and
to provide such employees and consultants with adequate  incentive through their
proprietary  interest in the Company,  it is necessary to increase the number of
shares  available  for  issuance  under the  Option  Plan.  The  Company  has no
retirement  plan to which it is currently  making  contributions.  Stock options
serve  as an  incentive  which  rewards  employees  and  consultants  for  their
performance and for business  successes  reflected in stock price  appreciation.
Upon approval of the proposed  1,500,000  share increase in the number of shares
reserved for issuance under the Option Plan, the total number of shares reserved
for  issuance  will  represent  approximately  14% of the number of  outstanding
shares.  The aggregate  number of shares reserved for issuance  includes options
previously granted and exercised under the Option Plan.

     The Option  Plan was  adopted by the Board of  Directors  and  approved  by
Collagen Corporation as the sole stockholder in January 1991, and 450,000 shares
of Common Stock were initially reserved for issuance  thereunder.  The number of
shares reserved for issuance under the Option Plan was subsequently increased by
450,000 shares,  to a total of 900,000  reserved  shares.  At the September 1992
Annual Meeting,  shareholders  approved an additional  increase of the number of
shares of Common Stock  reserved for issuance  thereunder by 600,000 shares to a
total of 1,500,000 shares.

     Prior  to an  amendment  approved  by the  Company's  Board  of  Directors,
nonemployee  directors  were not eligible to receive stock option grants under a
stock  option plan  qualified  within the meaning of certain  rules  promulgated
under Section 16 of the Securities  Exchange Act of 1934. As a result of changes
in such  rules  adopted  by the  Securities  and  Exchange  Commission  in 1996,
nonemployee  directors are now permitted to be eligible to receive  grants under
discretionary  option  plans.  Although  no grants  of  options  to  nonemployee
directors  under  the  Option  Plan are  currently  contemplated,  the  Board of
Directors  believes that it is in the best  interests of the Company to maintain
the  flexibility to make such grants if the Board  determines it to be necessary
to attract or retain  qualified  individuals to serve on the Board of Directors.
For this  reason,  the Board has  approved  the  amendment to the Option Plan to
permit  nonemployee  directors  of the Company to be eligible to receive  grants
under the Option Plan.

     Through July 15, 1997, options to purchase an aggregate of 1,500,774 shares
of Common Stock (net of options  canceled,  and of which options to purchase 774
shares are  subject to  stockholder  approval of this  Proposal  No. 2) had been
granted pursuant to the Option Plan,  options to purchase 32,174 shares had been
exercised and options to purchase  1,468,600  shares  remained  outstanding at a
weighted average exercise price of $2.59 per share.

                                      -5-



Summary of the Option Plan

     The following is a summary of the essential features of the Option Plan, as
amended by the Board of Directors. The summary,  however, does not purport to be
a complete description of all the provisions of the Option Plan. Any stockholder
who wishes to obtain a copy of the actual plan  document  may do so upon written
request to the Company's  Chief  Financial  Officer at the  Company's  principal
office.

     General

     Options granted under the Option Plan may be either incentive stock options
("ISOs") within the meaning of Section 422 of the Internal Revenue Code of 1986,
as  amended  (the  "Code"),  or  nonstatutory  stock  options  ("NSOs")  at  the
discretion  of the  Board of  Directors  and as  reflected  in the  terms of the
written  option  agreement.  However,  to the extent an optionee  would have the
right in any calendar year to exercise for the first time one or more  incentive
stock options for shares having an aggregate  fair market value (under all plans
of the  Company  and  determined  for each  share as of the date the  option  to
purchase the share was granted) in excess of $100,000,  any such excess  options
shall be  treated  as  nonstatutory  stock  options.  The  Option  Plan is not a
qualified  deferred  compensation  plan under Section 401(a) of the Code, and is
not subject to the provisions of the Employee  Retirement Income Security Act of
1974, as amended.  Shares not purchased  under an option prior to its expiration
will be available  for future  option  grants under the Option Plan.  The actual
benefits,  if any, to the holders of stock options  issued under the Option Plan
are not  determinable  prior to  exercise  as the value,  if any,  of such stock
options to their holders is  represented  by the  difference  between the market
price of a share of the  Company's  Common Stock on the date of exercise and the
exercise price of a holder's stock option, as set forth below.

     Purpose

     The  purposes of the Option Plan are to  attract,  motivate  and retain the
best available personnel for the Company, to provide additional incentive to the
employees and consultants and to promote the success of the Company's business.

     Administration

     If permitted by Rule 16b-3 promulgated under the Exchange Act, the Plan may
be  administered by different  administrative  bodies with respect to directors,
officers who are not  directors  and  employees  who are neither  directors  nor
officers.  Option  grants to directors and officers may be  administered  by the
Board or a Committee designated by the Board, in each case if in compliance with
Rule  16b-3  and  applicable  laws.  Option  grants  to  other  persons  may  be
administered  by  the  Board  or a  Committee  designated  by the  Board,  if in
compliance with applicable laws. The Option Plan is currently being administered
by the Compensation  Committee of the Board of Directors.  If all members of the
Compensation  Committee do not meet the definition of "outside  directors" under
Code Section 162(m), a subcommittee of the

                                      -6-



Compensation  Committee  consisting  of such "outside  directors"  will have the
exclusive  authority to grant stock  options and purchase  rights and  otherwise
administer the Option Plan with respect to "covered employees" described in Code
Section 162(m)  (generally the Company's highest paid executive  officers).  All
questions  of   interpretation   of  the  Option  Plan  are  determined  by  the
Administrator and its decisions are final and binding upon all participants. The
directors  receive no additional  compensation  for their services in connection
with the administration of the Option Plan.

     Eligibility

     The  Option  Plan  provides  that  options  may  be  granted  to  employees
(including officers and directors who are also employees) and consultants.  ISOs
may be granted only to  employees.  The Board of  Directors or the  Compensation
Committee  selects  the  optionees  and  determines  the  number of shares to be
subject to each option.  In making such  determination,  a number of factors are
taken into account,  including the duties and  responsibilities of the optionee,
the value of the optionee's services to the Company,  the optionee's present and
potential  contribution  to the  success  of the  Company,  and  other  relevant
factors.

     The Option Plan provides that the maximum  number of shares of Common Stock
which may be granted  under  options to any one employee  during any fiscal year
shall be 500,000, subject to adjustment as provided in the Option Plan. There is
also a limit on the  aggregate  market value of shares  subject to all incentive
stock options that may be granted to an optionee during any calendar year.

     Terms of Options

     The terms of options  granted  under the Option Plan are  determined by the
Compensation  Committee.  Each option is evidenced  by a stock option  agreement
between the Company and the optionee and is subject to the following  additional
terms and conditions:

         (a) Exercise of the Option.  The Board of  Directors  or its  committee
     determines  when  options may be  exercised.  An optionee  may  exercise an
     option by giving written  notice of exercise to the Company  specifying the
     number of full  shares of Common  Stock to be  purchased  and by  tendering
     payment of the purchase  price.  The purchase price is payable in such form
     of  consideration  as is  determined  by  the  Board  of  Directors  or its
     committee, and such form of consideration may vary for each option.

         (b) Exercise Price. The exercise price of each option granted under the
     Option Plan including options granted to "covered employees" under Internal
     Revenue Code Section 162(m) of the 1986 Internal  Revenue Code, as amended,
     is  determined  by the Board of Directors or its  committee  and may not be
     less than 100% of the fair market  value of the  Company's  Common Stock on
     the date the  option is granted in the case of an ISO and not less than 85%
     in the case of an NSO, except in the case of "covered employees".  The fair
     market value under the option plan is deemed to be the closing price on the
     Nasdaq National  Market on the date of grant of the option.  In the case of
     an option granted to an

                                      -7-



     optionee who owns stock  representing  more than 10% of the voting power of
     all  classes of stock of the  Company,  any parent or any  subsidiary,  the
     option  price  must not be less than 110% of the fair  market  value on the
     date of the grant.

         (c)  Termination  of  Employment.   If  the  optionee's  employment  or
     consulting  relationship  terminates  for any  reason  other  than death or
     disability,  options  under the Option Plan may be exercised not later than
     30 days (or such other period of time not  exceeding 90 days in the case of
     an ISO as is  determined by the Board of Directors or its  committee,  with
     such determination in the case of an ISO being made at the time of grant of
     the option) after such  termination and may be exercised only to the extent
     the option was exercisable on the date of termination.

         (d)  Disability.  If an  optionee  is  unable  to  continue  his or her
     employment or consulting  relationship  with the Company as a result of his
     or her total and permanent  disability,  options may be exercised  within 6
     months  (or such  other  period  of time not  exceeding  12  months,  as is
     determined  by  the  Board  of  Directors  or  its  committee,   with  such
     determination  in the case of an ISO being made at the time of the grant of
     the option) from the date of such  termination and may be exercised only to
     the extent the option was exercisable on the date of termination.

         (e)  Death.  If  an  optionee  should  die  (i)  while  employed  by or
     consulting to the Company,  options may be exercised  within 6 months after
     the date of death to the extent the options  would have been  exercisable 6
     months  after  the  date  of  death,  or  (ii)  within  30  days  following
     termination  of  the  optionee's  employment  or  consulting  relationship,
     options  may be  exercised  within 6 months  after the date of death to the
     extent the options would have been  exercisable  on the date of termination
     of employment or consulting relationship.

         (f) Expiration of Options. Options granted under the Option Plan expire
     10 years from the date of grant or on such  earlier date as is specified in
     the option  agreement.  Options  granted to an  optionee  who,  immediately
     before the grant of such option,  owned more than 10% of the total combined
     voting  power  of all  classes  of  stock of the  Company  or a  parent  or
     subsidiary  may not have a term of more  than 5  years.  No  option  may be
     exercised by any person after such expiration.

         (g)  Nontransferability of Options. An option is nontransferable by the
     optionee, other than by will or the laws of descent or distribution, and is
     exercisable during the optionee's  lifetime only by the optionee or, in the
     event of the  optionee's  death,  by a person  who  acquires  the  right to
     exercise the option by bequest or  inheritance or by reason of the death of
     the optionee.

         (h) Other  Provisions.  The option  agreement  may  contain  such other
     terms,  provisions and conditions not inconsistent  with the Option Plan as
     may be determined by the Board of Directors or its committee.

                                      -8-




     Adjustment Upon Changes in Capitalization, Sale or Merger

     In the event any change is made in the Company's capitalization,  such as a
stock split or  dividend,  that results in an increase or decrease in the number
of outstanding  shares of Common Stock without receipt of  consideration  by the
Company,  an appropriate  adjustment  shall be made in the exercise price and in
the number of shares subject to each option.  In the event of a proposed sale of
all or  substantially  all of the  assets of the  Company,  or the merger of the
Company  with or into  another  corporation,  the  Company is required to either
cause  outstanding  options to be assumed or substituted by the acquiring entity
or provide for  optionees to have the right to exercise  their options as to all
shares subject to such options,  including  shares as to which the options would
not  otherwise  be  exercisable,  for a period of 60 days from the date when the
optionees are notified of such action, after which such options terminate.

     Amendment and Termination of the Plan

     The Board of Directors or its committee may amend the Option Plan from time
to time in such  respect as the Board of  Directors  or its  committee  may deem
advisable;  provided,  however,  that to the extent  necessary  and desirable to
comply with Rule 16b-3 under the Exchange Act or with Section 422 of the Code or
with any other  successor or  applicable  law or  regulation,  the Company shall
obtain stockholder approval of any Option Plan amendment in such a manner and to
such a degree as is required by the applicable law, rule or regulation. However,
no action by the Board of Directors, its committee or the stockholders may alter
or impair any  option  previously  granted  under the Option  Plan  without  the
consent of the optionee.  The Option Plan terminates in 2001 (unless  terminated
at an earlier date by the Board of  Directors),  provided  that any options then
outstanding under the Option Plan remain  outstanding until they expire by their
terms.

Federal Income Tax Aspects of the Option Plan

     The following is a brief summary of the federal income tax  consequences of
transactions under the Option Plan based on federal income tax laws in effect on
the Record  Date.  This summary is not  intended to be  exhaustive  and does not
address all matters which may be relevant to a particular  optionee based on his
or her specific circumstances. The summary addresses only current federal income
tax  law and  expressly  does  not  discuss  the  income  tax law of any  state,
municipality or non-U.S.  taxing  jurisdiction or gift, estate or other tax laws
other than federal income tax law. The Company  advises all optionees to consult
their  own tax  advisors  concerning  tax  implications  of  option  grants  and
exercises and the  disposition of stock  acquired upon such exercises  under the
Option Plan.

     Options  granted  under  the  Option  Plan may be  either  incentive  stock
options,  as defined in Section 422 of the Code, or nonstatutory  stock options.
If an option granted under the Option Plan is an incentive  stock option,  under
federal  tax laws the  optionee  will  recognize  no  income  upon  grant of the
incentive  stock  option and will incur no tax  liability  due to the  exercise,
except to the extent that such exercise causes the optionee to incur alternative
minimum tax. (See discussion below). The Company will not be allowed a deduction
for  federal  income tax  purposes

                                      -9-



as a result of the  exercise of an  incentive  stock  option  regardless  of the
applicability  of the alternative  minimum tax. Upon the sale or exchange of the
shares more than two years after grant of the option and one year after exercise
of the option by the  optionee,  any gain will be treated as  long-term  capital
gain under federal tax laws. If both of these holding periods are not satisfied,
the optionee will recognize  ordinary income under federal tax laws equal to the
difference  between the exercise price and the lower of the fair market value of
the  Common  Stock at the date of the option  exercise  or the sale price of the
Common  Stock.  A  different  rule for  measuring  ordinary  income  upon such a
premature disposition may apply if the optionee is also an officer, director, or
10%  stockholder of the Company.  The Company will be entitled to a deduction in
the same amount as the ordinary  income  recognized  by the  optionee.  Any gain
recognized  on a  disposition  of the shares prior to  completion of both of the
above holding periods in excess of the amount treated as ordinary income will be
characterized  under  federal  tax laws as  long-term  capital  gain if the sale
occurs more than one year after exercise of the option or as short-term  capital
gain if the sale is made earlier. For individual taxpayers,  the current federal
tax rate on long-term  capital gains is capped at 28%,  whereas the maximum rate
on other income is 39.6%,  although proposed legislation is currently pending in
Congress which would reduce the maximum federal tax rate applicable to long-term
capital gains. Capital losses are allowed under federal tax laws in full against
capital gains plus $3,000 of other income.

     The exercise of an  incentive  stock option may subject the optionee to the
alternative  minimum tax under Section 55 of the Code.  The federal  alternative
minimum tax is calculated by applying a tax rate of 26% to  alternative  minimum
taxable  income of joint filers up to $175,000  ($87,500  for married  taxpayers
filing  separately)  and 28% to  alternative  minimum  taxable income above that
amount.  Alternative minimum taxable income for federal tax purposes is equal to
(i) taxable income adjusted for certain items, plus (ii) items of tax preference
less (iii) an exclusion of $45,000 for joint returns and $33,750 for  individual
returns.  Alternative  minimum tax will be due if the tax  determined  under the
foregoing  formula  exceeds  the regular tax of the  taxpayer  for the year.  In
computing  alternative minimum taxable income, shares purchased upon exercise of
an  incentive  stock  option  are  treated as if they had been  acquired  by the
optionee  pursuant to exercise of a nonstatutory  stock option (see below). As a
result, the optionee  generally  recognizes  alternative  minimum taxable income
equal to the excess of the fair market  value of the Common Stock on the date of
exercise over the option's exercise price.  Because the alternative  minimum tax
calculation may be complex,  any optionee who upon exercising an incentive stock
option would recognize  (together with other alternative  minimum taxable income
preference and adjustment items for the year) alternative minimum taxable income
in excess of the exclusion  amount noted above should consult his or her own tax
advisor prior to  exercising  the  incentive  stock option.  If an optionee pays
alternative  minimum  tax,  the amount of such tax may be  carried  forward as a
credit  against any subsequent  year's regular tax in excess of the  alternative
minimum tax for such year.  Proposed  legislation  currently pending in Congress
would  modify  certain of the federal  alternative  minimum tax rules  described
above.

     All other  options  which do not  qualify as  incentive  stock  options are
referred to as  nonstatutory  stock options.  An optionee will not recognize any
taxable  income  under  federal  tax  laws at the  time he or she is  granted  a
nonstatutory stock option.  However,  upon its exercise,  under federal tax laws
the optionee will  recognize  ordinary  income for tax purposes  measured by 

                                      -10-



the excess of the then fair market value of the shares over the exercise  price.
In certain circumstances,  where the shares are subject to a substantial risk of
forfeiture  when  acquired or where the optionee is an officer,  director or 10%
stockholder  of the Company,  the date of taxation under federal tax laws may be
deferred unless the optionee files an election with the Internal Revenue Service
under  Section  83(b) of the  Code.  The  income  recognized  by a  nonstatutory
optionee  who is  also  an  employee  of the  Company  will  be  subject  to tax
withholding  by the  Company by payment by the  optionee of the taxes in cash or
out of the current earnings paid to the optionee.  Upon resale of such shares by
the optionee, any difference between the sale price and the optionee's tax basis
(exercise price plus the income  recognized upon exercise) will be treated under
federal tax laws as capital gain or loss, and will qualify for long-term capital
gain or loss treatment if the shares have been held for more than one year.

Required Vote

     The amendment to the Option Plan to increase the number of shares of Common
Stock  reserved  for  issuance  thereunder  by  1,500,000  shares  and to permit
nonemployee  members of the  Company's  Board of  Directors  to be  eligible  to
receive stock option grants under the Option Plan requires the affirmative  vote
of the holders of a majority of the shares of the Company's Common Stock present
or by proxy and entitled to vote at the meeting.

     THE BOARD OF DIRECTORS  RECOMMENDS  A VOTE FOR THE  AMENDMENT TO THE OPTION
PLAN AS DESCRIBED ABOVE.

                                      -11-




                                 PROPOSAL NO. 3
               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS

     The  Board  of  Directors  has  selected  Ernst  & Young  LLP,  independent
auditors,  to audit the financial  statements of the Company for the fiscal year
ending  March  31,  1998,  and  recommends  that  the   stockholders   vote  for
ratification of such  appointment.  In the event the  stockholders do not ratify
such appointment,  the Board of Directors will reconsider its selection. Ernst &
Young LLP has audited the Company's financial statements since its incorporation
(December 1990), and previously audited the financial  statements of the Company
as a division of Collagen  Corporation,  and as a division of a former  Collagen
subsidiary.  Representatives  of Ernst & Young LLP are expected to be present at
the meeting  with the  opportunity  to make a statement if they desire to do so,
and are expected to be available to respond to appropriate questions.

     THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  RATIFICATION  OF THE
APPOINTMENT OF ERNST & YOUNG LLP AS INDEPENDENT AUDITORS FOR THE COMPANY.

                                      -12-




                  COMMON STOCK OWNERSHIP OF CERTAIN BENEFICIAL
                              OWNERS AND MANAGEMENT

     The following  table sets forth the  beneficial  ownership of the Company's
Common  Stock as of July 15,  1997,  as to (i) each  person  who is known by the
Company  to  beneficially  own more than five  percent of the  Company's  Common
Stock, (ii) each of the Company's current directors, (iii) each of the executive
officers  named in the  Summary  Compensation  Table  on page  15,  and (iv) all
current directors and executive officers as a group.

                                                       Shares Beneficially Owned
                                                                   (1)
                                                        -----------------------
5% Stockholders, Directors, Named Executive Officers,
   and Directors and Executive Officers as a Group         Number     Percent
- ------------------------------------------------------  ------------ ----------
Warburg, Pincus Investors, L.P. (2) .................     4,330,330    19.6%
466 Lexington Avenue, Tenth Floor
New York, NY 10017

Genzyme Corporation .................................     3,023,217    14.4%
One Kendall Square
Cambridge, MA 02139

Dawson-Samberg Capital Management, Inc. (3) .........     2,576,032    11.8%
354 Pequot Avenue
Southport, CT 06490

Biotechnology Development Fund, L.P. (4) ............     1,845,774     8.6%
575 High Street, Suite 201
Palo Alto, CA 94301

Henry E. Blair (5) ..................................     3,029,883    14.4%

Mary Anne Ribi (6) ..................................        51,363      *

David M. Rosen, Ph.D. (6) ...........................        52,405      *

Andreas Sommer, Ph.D. (6) ...........................       183,811      *

James E. Thomas (7) .................................     4,330,330    19.6%

All directors and executive officers as a group
(6 persons) (8) .....................................       306,245     1.4%

- ---------------------

     *Less than 1%.

(1)  Information with respect to beneficial  ownership is based upon information
     furnished  by each  director  and officer or contained in filings made with
     the  Securities  and  Exchange  Commission.  Except  as  indicated  in  the
     footnotes  to this  table,  the  stockholders  named in the table have sole
     voting  and  investment  power with  respect to all shares of Common  Stock
     shown as  beneficially  owned by them,  subject to community  property laws
     where applicable.

                                      -13-



(2)  Warburg,  Pincus Investors,  L.P. ("WPI") is a Delaware limited partnership
     whose sole  general  partner is Warburg,  Pincus & Co., a New York  general
     partnerhsip  ("WP").  E. M. Warburg,  Pincus & Co., LLC, a New York limited
     liability  company  ("EMW  LLC"),  manages  WP. The  members of EMW LLC are
     substantially  the same as the  partners  of WP.  Lionel  I.  Pincus is the
     managing partner of WP and the managing member of EMW LLC and may be deemed
     to control both WP and EMW LLC. WP, as the sole general partner of WPI, has
     a 20% interest in the profits of WPI. Mr. James E. Thomas,  Chairman of the
     Board of Directors of the Company, is a Managing Director and member of EMW
     LLC and a general  partner of WP. As such, Mr. Thomas may be deemed to have
     an indirect  pecuniary interest (within the meaning of Rule 16a-1 under the
     Securities Exchange Act of 1934) in an indeterminable portion of the shares
     beneficially  owned by WPI and WP.  Number  of  shares  beneficially  owned
     include a warrant for the purchase of 687,155  shares of Common Stock at an
     exercise  price of $9.00 which expires on November 17, 1998,  and a warrant
     for the purchase of 461,443  shares of Common Stock at an exercise price of
     $2.68 which expires on April 1, 2000.

(3)  Includes  2,184,456  shares held by Pequot  Private  Equity Fund,  L.P. (of
     which 728,152 shares are issuable upon exercise of a warrant at an exercise
     price of $2.68 and which expires on April 1, 2000),  276,576 shares held by
     Pequot  Offshore  Private  Equity Fund,  Inc.  (of which 92,192  shares are
     issuable upon exercise of a warrant at an exercise price of $2.68 and which
     expires on April 1, 2000),  and 115,000  shares held by Pequot  Scout Fund,
     L.P.

(4)  Includes a warrant for the purchase of 615,258 shares of Common Stock at an
     exercise price of $2.68 which expires on April 1, 2000.

(5)  3,023,217 of the shares  indicated as owned by Mr. Blair are owned directly
     by Genzyme Corporation  ("Genzyme") and are included because Mr. Blair is a
     member  of  the  Board  of  Directors  of  Genzyme.   Mr.  Blair  disclaims
     "beneficial  ownership"  of these  shares  within the meaning of Rule 13d-3
     under the Securities  Exchange Act of 1934;  therefore,  the shares are not
     reflected  in the total  number of shares held by officers  and  directors.
     Also,  includes 6,666 shares issuable upon exercise of options  exercisable
     within  60 days  after  July  15,  1997.  See  "Election  of  Directors  --
     Nominees."

(6)  As to each of Ms. Ribi, Dr. Rosen and Dr. Sommer,  includes 49,950, 52,405,
     and  162,350  shares,  respectively,  issuable  upon  exercise  of  options
     exercisable within 60 days after July 15, 1997.

(7)  All of the shares  indicated as owned by Mr.  Thomas are owned  directly by
     Warburg,  Pincus Investors  ("WPI") and are included because of Mr. Thomas'
     affiliation with WPI. Mr. Thomas disclaims "beneficial  ownership" of these
     shares within the meaning of Rule 13d-3 under the  Securities  Exchange Act
     of 1934;  therefore,  the shares are not  reflected  in the total number of
     shares held by officers  and  directors.  See  "Election  of  Directors  --
     Nominees."

(8)  Includes  283,371 shares issuable upon exercise of options held by officers
     and  directors  exercisable  within 60 days after July 15, 1997,  including
     shares issuable upon exercise of options held by the officers and directors
     named in the foregoing table, but excludes such shares for which beneficial
     ownership  is  disclaimed  within  the  meaning  of Rule  13d-3  under  the
     Securities Exchange Act of 1934.

                                      -14-




                       COMPENSATION OF EXECUTIVE OFFICERS

                           Summary Compensation Table


     The following table shows the compensation  received by the Chief Executive
Officer  and the most  highly  compensated  executive  officers  of the  Company
earning  over  $100,000  for the  fiscal  year  ended  March 31,  1997,  and the
compensation received by each such individual for the Company's two prior fiscal
years.


                                                                                 Long Term
                                                           Annual              Compensation
                                                        Compensation (1)          Awards (1)
                                                         -----------           ------------
                                                                                 Options/          All Other
     Name and Principal Position          Year           Salary (2)            SARS Granted     Compensation (1)
     ---------------------------          ----           ----------            ------------     ----------------
                                                                                      
Andreas Sommer                            1997           $212,925
   Chief Executive Officer, President     1996           $188,116                147,500
   and Director                           1995           $163,756                162,500 (3)      $16,037 (4)

Mary Anne Ribi                            1997           $136,463
    Vice President, Finance and           1996           $120,572                 75,000
    Administration, Chief Financial       1995            $92,245                 25,000 (5)
    Officer and Assistant Secretary

David M. Rosen                            1997           $136,463
   Vice President, Research and           1996           $123,719                 76,250
   Development                            1995           $107,338                 23,750 (6)


<FN>
- ----------------------
(1)  Except as  disclosed  in the table,  there was no other cash  compensation,
     long-term   incentive   plan  or  restricted   stock  award  that  required
     disclosure.

(2)  Includes amounts earned but deferred at the election of the executive, such
     as salary  deferrals under Celtrix's  retirement  savings plan ("the 401(k)
     Plan").

(3)  Includes  57,500  shares of Incentive  Stock  Options  ("ISOs")  granted in
     connection with the Company's  November 1994 option repricing,  pursuant to
     which option holders were entitled to cancel their  outstanding  options in
     exchange for new options covering 50% of their original  underlying  shares
     with an exercise  price of $2.50 per share,  the fair  market  value of the
     Company's stock on the date of Board approval. Vesting period is 1/24th per
     month for options  with  original  grant dates prior to April 1, 1993,  and
     1/50th per month for options with original grant dates after April 1, 1993.

(4)  Consists of relocation costs reimbursed, including gross-up payment for tax
     liability incurred on such costs.

(5)  Includes  10,000  shares of ISOs granted in  connection  with the Company's
     November 1994 option repricing.

(6)  Includes  18,750  shares of ISOs granted in  connection  with the Company's
     November 1994 option repricing.

</FN>


                                      -15-




                 Aggregated Option Exercises in Last Fiscal Year
                        and Fiscal Year-End Option Values


     The following table sets forth information for the named executive officers
with  respect to  exercises,  during the fiscal  year ended March 31,  1997,  of
options to purchase  Common  Stock of the  Company,  and the number and value of
unexercised options at fiscal year end.


                                                                                                 Value of
                                                                      Number of                 Unexercised
                                                                     Unexercised               In-the-Money
                                                                      Options at                  Options
                                 Shares                            Fiscal Year-End          at Fiscal Year-End
                                Acquired            Value           (Exercisable/              (Exercisable/
          Name                 On Exercise        Realized          Unexercisable)          Unexercisable) (1)
- --------------------------  ------------------  --------------  -----------------------  --------------------------
                                                                                  
Andreas Sommer                       0               $0           138,350/136,650             $39,620/$46,510
Mary Anne Ribi                       0               $0            40,700/59,300                   $0/$0
David M. Rosen                       0               $0            43,355/56,645              $14,345/$16,840

<FN>
- -----------------
(1)  The fair market value of  Celtrix's  Common Stock as reported on the Nasdaq
     National  Market at the close of business on March 31,  1997  ($2.438)  was
     lower  than  the  exercise  price  of most of the  options.  The  value  of
     unexercised-in-the-money options represents any positive spread between the
     exercise  price of the stock  options  and the  market  value of  Celtrix's
     Common Stock on March 31, 1997.
</FN>


                                      -16-




     Notwithstanding  anything to the contrary set forth in any of the Company's
previous filings under the Securities Act of 1933, as amended, or the Securities
Exchange  Act of 1934,  as  amended,  that  might  incorporate  future  filings,
including this Proxy Statement,  in whole or in part, the following Compensation
Committee Report on Executive  Compensation and the Performance Graph on page 20
shall not be incorporated by reference into any such filings.

             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

     The Compensation  Committee (the  "Committee") of the Board of Directors is
responsible for setting and  administering  the policies for executive  salaries
and  short-term  and  long-term  incentive  programs.  The  Committee  currently
consists  of Henry E.  Blair  and James E.  Thomas,  non-employee  directors  of
Celtrix. Andreas Sommer serves as an ex officio member.

Compensation Philosophy

     The  executive  compensation  program is designed  to  motivate  and retain
executives of outstanding ability who contribute to the long-term success of the
Company and is based on the following guiding principles:

     o   Integrate executives' compensation with accomplishment of the Company's
         strategic plan and business objectives.

     o   Provide a  compensation  package that is  competitive  with  comparable
         companies in the biotechnology industry.

     o   Assure that  executives  are focused on the  enhancement of stockholder
         value.

Compensation Program

     Compensation  for the Company's Chief  Executive  Officer ("CEO") and other
officers is based on individual  performance as measured against clearly defined
corporate  objectives.  The Board of Directors approves corporate  objectives at
the beginning of the fiscal year and reviews  progress  throughout the year. The
Compensation   Committee   determines   executive   compensation  based  on  the
accomplishment  of those objectives.  Corporate  objectives for fiscal 1997 were
identified in the areas of product development  milestones,  strategic corporate
alliances, staffing and financings. Executives' performance was measured against
these specific objectives.

     The two primary components of executives'  compensation are (1) base salary
and (2) long-term equity incentives. The Committee's goal in setting annual base
salaries is to be at the median salary level for similar  positions in companies
of comparable  size,  geographic  location (San  Francisco Bay Area and Southern
California) and industry sector  (biopharmaceuticals)  within the  biotechnology
industry. To determine these levels, the Committee refers to compensation survey
data from a select group of companies participating in the Radford Biotechnology
Salary  Survey.  All of these  companies  are also in the Nasdaq  Pharmaceutical
Stocks Index used in the Company's  Stock Price  Performance  Graph set forth in
the Proxy  Statement.  Each year,  the list of  companies  participating  in the
survey is reviewed,  and  additions

                                      -17-



or  deletions  are made to the  select  group of  companies  based on the  three
criteria used (size, geographic location, industry sector).

     Stock option awards are intended to align the  interests of the  executives
with those of the  stockholders  and provide  significant  incentive to meet the
Company's  long-term  goals and enhance  stockholder  value.  Stock  options are
granted at fair market value and vest over a 50-month period. In determining the
size of the option  grants,  several  factors are  considered:  size of previous
awards made to executives, competitive practices at similar companies within the
industry and perceived long-term contribution.

Compensation of the Chief Executive Officer

     The  CEO's  compensation  is  determined  based  on a  number  of  factors,
including  comparative  salaries  of  CEOs  of the  select  group  of  companies
identified above, the CEO's individual performance and the Company's performance
as measured against the stated objectives  discussed above.  Current base salary
for the CEO is in line with the  median for  similarly  situated  executives  in
other  companies of comparable  size in the  biotechnology  industry.  The CEO's
total  compensation  package  includes  stock  option  grants  with  the goal of
motivating  leadership for long-term  Company success and providing  significant
reward upon achievement of Company  objectives and enhancing  stockholder value.
As with  other  executives,  size of option  grants is also based on a review of
competitive survey data.

Deductibility of Executive Compensation

     The Committee has  considered  the impact of Section 162(m) of the Internal
Revenue Code adopted under the Omnibus Budget  Reconciliation Act of 1993, which
section disallows a deduction for any  publicly-held  corporation for individual
compensation exceeding $1 million in any taxable year for the CEO and four other
most highly compensated  executive officers,  unless such compensation meets the
requirements  for the  "performance-based"  exception to the general rule. Since
the cash compensation  paid by the Company to each of its executive  officers is
expected to be well below $1 million and the  Committee  believes  that  options
granted  under the Option  Plan will meet the  requirements  for a  transitional
exemption from the  application of Section 162(m),  the Committee  believes that
this section  will not affect the tax  deductions  available to the Company.  It
will be the  Committee's  policy  to  qualify,  to the  extent  reasonable,  the
executive officers' compensation for deductibility under applicable tax law.

     From the members of the Compensation Committee of Celtrix:

                             COMPENSATION COMMITTEE

                            Henry E. Blair - Chairman
                            James E. Thomas

                                      -18-



           COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

     Andreas Sommer, Ph.D. is an ex officio member of the Company's Compensation
Committee.  He assumed the  position in April 1995.  His status as an ex officio
member did not  entitle  him to vote on matters  submitted  to the  Compensation
Committee. Dr. Sommer presents to the Committee  recommendations on compensation
for other  named  executive  officers  but did not  participate  in  discussions
regarding his own compensation.

                                      -19-




                                PERFORMANCE GRAPH

     The following graph  summarizes  cumulative total  stockholder  return data
(assuming reinvestment of dividends) for the period commencing on March 31, 1992
and ending on March 31, 1997.  The graph assumes that $100 was invested on March
31, 1992 (i) in the Common Stock of Celtrix Pharmaceuticals, Inc. at a price per
share of $8.75,  (ii) in the Center for  Research  in  Securities  Prices  Total
Return  Index for the Nasdaq  Stock  Market  (U.S.  Companies)  and (iii) in the
Nasdaq  Pharmaceutical  Stocks Index. The stock price  performance  shown on the
following graph is not necessarily indicative of future stock price performance.

[The following  descriptive  data is supplied in accordance  with Rule 304(d) of
Regulation S-T]


                                                     COMPARISON OF TOTAL RETURN

              3/31/92  4/30/92  5/31/92  6/30/92  7/31/92  8/31/92  9/30/92  10/31/92  11/30/92  12/31/92  1/31/93  2/28/93  3/31/93
              -------  -------  -------  -------  -------  -------  -------  --------  --------  --------  -------  -------  -------

                                                                                         
NASDAQ TOTAL     100     95.7     96.9     93.1     96.4     93.5     97.0     100.8     108.8     112.8    116.1    111.7    114.5

NASDAQ PHARM     100     83.7     86.8     83.9     88.4     80.5     79.0      84.2      97.1      96.1     89.3     68.6     69.2

CELTRIX          100     91.4     88.6     68.6     81.4     74.3     65.7      77.1     104.3     114.3     95.7     70.0     78.6




              4/30/93   5/31/93   6/30/93   7/31/93   8/31/93   9/30/93  10/31/93  11/30/93  12/31/93   1/31/94   2/28/94   3/31/94
              -------   -------   -------   -------   -------   -------  --------  --------  --------   -------   -------   -------
                                                                                           
NASDAQ TOTAL   110.1     116.6     117.2     117.3     123.4     127.0     129.9     126.0     129.5     133.4     132.2     121.9

NASDAQ PHARM    69.9      72.8      72.9      70.8      74.6      79.1      86.0      84.2      85.7      88.3      80.3      69.9

CELTRIX         91.4      85.7      88.6      80.0      82.9      84.3     111.4     118.6     125.7     104.3      80.0      84.3




              4/30/94   5/31/94   6/30/94   7/31/94   8/31/94   9/30/94  10/31/94  11/30/94  12/31/94   1/31/95   2/28/95   3/31/95
              -------   -------   -------   -------   -------   -------  --------  --------  --------   -------   -------   -------
                                                                                           
NASDAQ TOTAL   120.3     120.6     116.2     118.6     126.1     125.8     128.3     124.0     124.4     125.1     131.7     135.5

NASDAQ PHARM    67.1      66.2      61.0      62.8      69.7      68.7      66.4      66.6      64.5      68.1      70.6      69.6

CELTRIX         68.6      78.6      71.4      68.6      90.0      81.4      27.9      34.3      30.0      31.4      21.4      17.1 




              4/28/95   5/31/95   6/30/95   7/31/95   8/31/95   9/30/95  10/31/95  11/30/95  12/31/95   1/31/96   2/29/96   3/31/96
              -------   -------   -------   -------   -------   -------  --------  --------  --------   -------   -------   -------
                                                                                           
NASDAQ TOTAL   139.9     143.5     154.9     166.1     169.5     176.9     175.9     180.1     179.1     179.9     186.8     187.4

NASDAQ PHARM    71.6      72.5      81.0      87.9      98.3     101.1      97.4     102.2     117.9     128.1     125.7     122.8

CELTRIX         15.8      18.5      29.3      28.6      27.2      27.9      22.9      20.7      29.3      25.8      27.9      28.6




              4/30/96   5/31/96   6/30/96   7/31/96   8/31/96   9/30/96  10/31/96  11/30/96  12/31/96   1/31/97   2/28/97   3/31/97
              -------   -------   -------   -------   -------   -------  --------  --------  --------   -------   -------   -------
                                                                                           
NASDAQ TOTAL   203.0     212.3     202.7     184.7     195.0     209.9     207.6     220.4     220.2     235.8     222.8     208.3

NASDAQ PHARM   129.1     133.5     119.2     106.3     114.0     121.9     116.4     114.8     118.3     128.2     129.1     112.3

CELTRIX         27.9      38.6      38.6      27.1      25.7      27.9      21.4      23.6      22.9      40.0      34.3      27.9



                                      -20-




                     TRANSACTIONS WITH MANAGEMENT AND OTHERS

     In April 1997,  Celtrix sold 5,721,876  shares of Common Stock in a private
placement at $2.438 per share,  which resulted in net proceeds to the Company of
approximately $13.3 million. In addition,  for every two shares of stock issued,
the Company also issued a three-year  warrant to purchase an additional share of
Celtrix Common Stock at $2.682 per share.  The warrants are exercisable  only if
the  shares  of stock  are held for at least  one year and are  callable  by the
Company  under  certain  conditions.  Purchasers  in the  offering  included the
following  holders of more than 5% of the  Company's  outstanding  Common Stock:
Warburg Pincus Investors,  L.P.,  Dawson-Samberg Capital Management (through the
Pequot  Private  Equity  and  Pequot   Offshore   Private  Equity  funds),   and
Biotechnology  Development Fund, L.P. In connection with the private  placement,
the Company paid BioAsia  LLC, an  affiliate  of the  Biotechnology  Development
Fund,  fees and  expenses  of  approximately  $538,000  and  granted  BioAsia  a
three-year  nonstatutory  stock  option  pursuant  to the Option Plan for 75,000
shares of Common Stock at an exercise price of $2.438 per share.

     In January 1997, the Company entered into a two-year  employment  agreement
with Andreas Sommer which provides in pertinent part for annual  compensation of
$215,000 as subsequently adjusted by the Compensation Committee, up to 18 months
severance and  forgiveness of the loan described in the next  paragraph,  in the
event of termination of employment under certain circumstances.

     In January 1992,  the Company loaned Dr. Sommer $60,000 to pay income taxes
associated  with Dr.  Sommer's  exercise of his  options to  purchase  BioGrowth
Common  Stock.  The loan is  secured  by Dr.  Sommer's  Celtrix  stock and bears
interest at the rate of 5.12% per annum,  with a due date of January 1999. As of
July 15, 1997,  the amount of  indebtedness  under such loan was $77,473 and the
maximum  amount owed under such loan during the fiscal year ended March 31, 1997
was $76,495.

     In  February  1997,  the  Company  entered  into  a  management  continuity
agreement  with Ms. Ribi which  provides  for up to 30 weeks of severance in the
event of termination of employment following a change in control of the Company.

     The Company has entered into separate indemnification  agreements with each
of its  directors and  executive  officers  that may require the Company,  among
other things,  to indemnify them against certain  liabilities  that may arise by
reason of their status or service as directors  or  officers,  to advance  their
expenses  incurred as a result of any  proceeding  against them as to which they
could be indemnified, and to obtain directors' and officers' liability insurance
if available on reasonable terms.

     The Company  believes that the transactions set forth above are on terms no
less  favorable to the Company than could have been obtained  from  unaffiliated
third parties.  All future material  transactions,  including loans, between the
Company and its officers, directors,  principal stockholders and affiliates will
be approved by a majority of the Board of Directors, including a majority of the
independent and disinterested  outside directors on the Board of Directors,  and

                                      -21-



will be on terms no less  favorable to the Company  than could be obtained  from
unaffiliated third parties.

                        COMPLIANCE WITH SECTION 16(a) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

     Section 16(a) of the Securities  Exchange Act of 1934 (the "Exchange  Act")
requires the Company's  directors and  executive  officers,  and persons who own
more  than ten  percent  (10%) of a  registered  class of the  Company's  equity
securities  to file with the  Securities  and  Exchange  Commission  (the "SEC")
initial reports of ownership and reports of changes in ownership of Common Stock
and  other  equity   securities   of  the  Company.   Officers,   directors  and
greater-than-ten-percent stockholders are required by SEC regulations to furnish
the Company with copies of all Section 16(a) forms they file.

     To the Company's knowledge,  based solely upon review of the copies of such
reports furnished to the Company and written  representations  from officers and
directors  that no other  reports were  required,  during the three fiscal years
ended March 31, 1997,  all Section 16(a) filing  requirements  applicable to its
officers,  directors  and  greater-than-ten-percent  stockholders  were complied
with.


                             DEADLINE FOR RECEIPT OF
                  STOCKHOLDER PROPOSALS FOR 1998 ANNUAL MEETING

     Proposals of  stockholders of the Company that are intended to be presented
by such  stockholders at the Company's 1998 Annual Meeting of Stockholders  must
be received by the Company no later than March 24, 1998,  in order that they may
be included in the proxy statement and form of proxy relating to that meeting.


                                  OTHER MATTERS

     The Board of  Directors  knows of no other  matters to be  submitted to the
stockholders  at the  meeting.  If any other  matters  properly  come before the
meeting,  it is the intention of the persons named in the enclosed form of Proxy
to vote the shares they represent as the Board of Directors may recommend.


                                     FOR THE BOARD OF DIRECTORS

                                     CRAIG W. JOHNSON, Secretary

Dated:  July 21, 1997

                                      -22-



                          CELTRIX PHARMACEUTICALS, INC.

                             1991 STOCK OPTION PLAN

             (as amended by the Board of Directors on May 10, 1991,
                         May 11, 1992, and April 9 1997)

     1.  Purposes of the Plan.  The  purposes  of this Stock  Option Plan are to
attract and retain the best  available  personnel for  positions of  substantial
responsibility,  to provide additional incentive to Employees and Consultants of
the Company  and its  Subsidiaries  and to promote the success of the  Company's
business.  Options  granted  under the Plan may be incentive  stock  options (as
defined  under  Section  422 of the  Code) or  nonstatutory  stock  options,  as
determined by the  Administrator  at the time of grant. of an option and subject
to the  applicable  provisions of Section 422 of the Code,  as amended,  and the
regulations promulgated thereunder.

     2. Definitions. As used herein, the following definitions shall apply:

         (a) "Administrator"  means the Board or any of its Committees appointed
pursuant to Section 4 of the Plan.

         (b) "Board" means the Board of Directors of the Company.

         (c) "Code" means the Internal Revenue Code of 1986, as amended.

         (d) "Committee" means the Committee appointed by the Board of Directors
in accordance with paragraph (a) of Section 4 of the Plan.

         (e) "Common Stock" means the Common Stock of the Company.

         (f)  "Company"   means  Celtrix   Pharmaceuticals,   Inc.,  a  Delaware
corporation.

         (g) "Consultant" means any person, including an advisor, who is engaged
by the Company or any Parent or Subsidiary to render services and is compensated
for such services,  and any director of the Company whether compensated for such
services  or not  provided  that if and in the event the Company  registers  any
class of any equity  security  pursuant to the Exchange Act, the term Consultant
shall  thereafter  not  include  directors  who are not  compensated  for  their
services or are paid only a director's fee by the Company.

        (h)  "Continuous  Status  as an  Employee"  means  the  absence  of  any
interruption or termination of the employment relationship by the Company or any
Subsidiary. Continuous Status as an Employee shall not be considered interrupted
in the case of: (i) sick  leave,  military  leave or any other  leave of absence
approved by the Board,  provided  that, in the case of incentive  stock options,
such  leave  is  for a  period  of  not  more  than  ninety  (90)  days,  unless
reemployment  upon the  expiration  of such  leave is  guaranteed  by  contract,
statute  or Company  policy  adopted  from time to time;  or (ii) in the case of
transfers  between  locations  of  the  Company  or  between  the  Company,  its
Subsidiaries or its successor.






         (i)  "Employee"  means any person,  including  officers and  directors,
employed by the Company or any Parent or Subsidiary of the Company.  The payment
of a  director's  fee by the  Company  shall  not be  sufficient  to  constitute
"employment" by the Company.

         (j)  "Exchange  Act"  means the  Securities  Exchange  Act of 1934,  as
amended.

         (k) "Fair  Market  Value"  means,  as of any date,  the value of Common
Stock determined as follows:

               (i) If the  Common  Stock  is  listed  on any  established  stock
exchange or a national market system including  without  limitation the National
Market System of the National Association of Securities Dealers,  Inc. Automated
Quotation  ("NASDAQ")  System,  its Fair Market Value shall be the closing sales
price for such stock (or the closing bid, if no sales were  reported,  as quoted
on such system or exchange for the last market  trading day prior to the time of
determination)  as reported in the Wall Street  Journal or such other  source as
the Administrator deems reliable;

               (ii) If the Common Stock is quoted on the NASDAQ  System (but not
on the  National  Market  System  thereof) or  regularly  quoted by a recognized
securities  dealer but selling  prices are not  reported,  its Fair Market Value
shall be the mean  between  the bid and asked  prices for the  Common  Stock or;
(iii) In the absence of an  established  market for the Common  Stock,  the Fair
Market Value thereof shall be determined in good faith by the Administrator.

         (l) "Incentive  Stock Option" means an Option intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code.

         (m) "Named Executive" shall mean any individual who, on the last day of
the Company's fiscal year, is the chief executive  officer of the Company (or is
acting in such capacity) or among the four highest  compensated  officers of the
Company (other than the Chief Executive  Officer).  Such officer status shall be
determined  pursuant to the executive  compensation  disclosure  rules under the
Securities Exchange Act of 1934, as amended.

         (n) "Nonstatutory Stock Option" means an Option not intended to qualify
as an Incentive Stock Option.

         (o) "Option" means a stock option granted pursuant to the Plan.

         (p) "Optioned Stock" means the Common Stock subject to an Option.

         (q) "Optionee" means an Employee or Consultant who receives an Option.

         (r)  "Parent"  means a "parent  corporation",  whether now or hereafter
existing, as defined in Section 424(e) of the Code.

                                      -2-



         (s) "Plan" means this 1991 Option Stock Plan.

         (t)  "Share"  means  a  share  of the  Common  Stock,  as  adjusted  in
accordance with Section 13 of the Plan.

         (u)  "Subsidiary"  means a  "subsidiary  corporation",  whether  now or
hereafter existing, as defined in Section 424(f) of the Code.

     3. Stock Subject to the Plan.  Subject to the provisions  Section 13 of the
Plan,  the maximum  aggregate  number of shares  which may be optioned  and sold
under the Plan is 3,000,000  shares Common Stock (the "Shares").  The shares may
be authorized, but of unissued, or reacquired Common Stock.

         If an  Option  should  expire or become  unexercisable  for any  reason
without having been exercised in full, the unpurchased Shares which were subject
thereto shall, unless the Plan shall have been terminated,  become available for
future grant under the Plan.

     4. Administration of the Plan.

         (a) Composition of Administrator.

               (i) Multiple  Administrative  Bodies.  If permitted by Rule 16b-3
promulgated  under  the  Exchange  Act or any  successor  rule  thereto,  ("Rule
16b-3"),  and by the  legal  requirements  relating  to  the  administration  of
incentive stock option plans, if any, of applicable  securities  laws,  Delaware
corporate law and the Code  (collectively,  the "Applicable Laws"), the Plan may
(but need not) be administered by different  administrative  bodies with respect
to  directors,  officers who are not  directors  and  Employees  who are neither
directors nor officers.

               (ii) Administration with respect to Directors and Officers.  With
respect to grants of Options to Employees or  Consultants  who are also officers
or directors of the Company, the Plan shall be administered by (A) the Board, if
the Board may make grants under the Plan in compliance with Rule 16b-3 and under
Section  162(m) of the Code as it applies so as to qualify  grants of Options to
Named  Executives  as  performance-based   compensation,   or  (B)  a  Committee
designated  by the  Board to  administer  the  Plan,  which  Committee  shall be
constituted  in such a manner as to permit  grants under the Plan to comply with
Rule 16b-3 to qualify grants of Options to Named Executives as performance-based
compensation under Section 162(m) of the Code and otherwise so as to satisfy the
Applicable Laws.

               (iii) Administration with respect to Other Persons.  With respect
to grants of Options to Employees or Consultants  who are neither  directors nor
officers of the Company,  the Plan shall be administered by (A) the Board or (B)
a Committee  designated by the Board,  which  Committee  shall be constituted in
such a manner as to satisfy the Applicable Laws.

               (iv)  General.  Once a Committee has been  appointed  pursuant to
subsection  (ii) or (iii) of this Section 4(a), such Committee shall continue to
serve in its

                                      -3-



designated capacity until otherwise directed by the Board. From time to time the
Board may  increase the size of any  Committee  and appoint  additional  members
thereof,  remove  members  (with or without  cause) and  appoint  new members in
substitution therefor, fill vacancies (however caused) and remove all members of
a Committee  and  thereafter  directly  administer  the Plan,  all to the extent
permitted by the Applicable Laws and, in the case of a Committee appointed under
subsection  (ii),  to the  extent  permitted  by Rule  16b-3  and to the  extent
required  under Section 162(m) of the Code to qualify grants of Options to Named
Executives as performance-based compensation.

         (b) Powers of the Administrator.  Subject to the provisions of the Plan
and in the case of a Committee,  the specific  duties  delegated by the Board to
such Committee, the Administrator shall have the authority, in its discretion:

               (i) to determine  the Fair Market Value of the Common  Stock,  in
accordance with Section 2(k) of the Plan;

               (ii) to select the  officers,  Consultants  and Employees to whom
Options may from time to time be granted hereunder;

               (iii) to determine whether and to what extent Options are granted
hereunder;

               (iv) to  determine  the  number of  shares of Common  Stock to be
covered by each such award granted hereunder;

               (v) to approve forms of agreement for use under the Plan;

               (vi) to determine the terms and conditions, not inconsistent with
the  terms of the Plan,  of any  award  granted  hereunder  (including,  but not
limited to, the share price and any  restriction or  limitation,  or any vesting
acceleration  or waiver of forfeiture  restrictions  regarding any Option and/or
the shares of Common Stock relating thereto,  based in each case on such factors
as the Administrator shall determine, in its sole discretion);

               (vii) to determine whether and under what circumstances an Option
may be settled in cash under subsection 9(f) instead of Common Stock;

               (viii) to  determine  whether,  to what  extent  and  under  what
circumstances  Common Stock and other  amounts  payable with respect to an award
under this Plan shall be deferred either automatically or at the election of the
participant  (including providing for and determining the amount, if any, of any
deemed earnings on any deferred amount during any deferral period); and

               (ix) to  reduce  the  exercise  price of any  Option  to the then
current Fair Market  Value if the Fair Market Value of the Common Stock  covered
by such Option shall have declined since the date the Option was granted;

                                      -4-



         (c) Effect of Committee's Decision.  All decisions,  determinations and
interpretations of the Administrator shall be final and binding on all Optionees
and any other holders of any Options.

     5. Eligibility.

         (a)  Nonstatutory  Stock  Options  may  be  granted  to  Employees  and
Consultants.  Incentive  Stock  Options  may be granted  only to  Employees.  An
Employee or  Consultant  who has been  granted an Option may, if he is otherwise
eligible, be granted an additional Option or Options.

         (b) Each Option shall be designated in the written option  agreement as
either an  Incentive  Stock  Option or a  Nonstatutory  Stock  Option.  However,
notwithstanding such designations,  to the extent that the aggregate Fair Market
Value of the Shares with respect to which Options  designated as Incentive Stock
Options are  exercisable  for the first time by any Optionee during any calendar
year  (under  all plans of the  Company  or any  Parent or  Subsidiary)  exceeds
$100,000, such excess Options shall be treated as Nonstatutory Stock Options.

         (c) For purposes of Section  5(b),  Incentive  Stock  Options  shall be
taken into account in the order in which they were granted,  and the Fair Market
Value of the Shares shall be  determined  as of the time the Option with respect
to such Shares is granted.

         (d) The Plan shall not confer upon any  Optionee any right with respect
to continuation of employment or consulting  relationship with the Company,  nor
shall it  interfere in any way with his or her right or the  Company's  right to
terminate his or her employment or consulting  relationship at any time, with or
without cause. 

     6. Term of Plan. The Plan shall become  effective upon the earlier to occur
of its adoption by the Board of Directors or its approval by the stockholders of
the Company as described in Section 19 of the Plan. It shall  continue in effect
for a term of ten (10) years unless  sooner  terminated  under Section 15 of the
Plan.

     7. Term of Option.  The term of each Option shall be the term stated in the
Option  Agreement;  provided,  however,  that in the case of an Incentive  Stock
Option,  the term  shall be no more than ten (10)  years  from the date of grant
thereof  or  such  shorter  term as may be  provided  in the  Option  Agreement.
However, in the case of an Incentive Stock Option granted to an Optionee who, at
the time the Option is granted,  owns stock  representing  more than ten percent
(10%) of the voting  power of all  classes of stock of the Company or any Parent
or  Subsidiary,  the term of the Option shall be five (5) years from the date of
grant thereof or such shorter term as may be provided in the Option Agreement.

     8. Option Exercise Price and Consideration.

         (a) The per share exercise  price for the Shares to be issued  pursuant
to exercise of an Option shall be such price as is determined by the Board,  but
shall be subject to the following:

                                      -5-



               (i) In the case of an Incentive Stock Option

                     (A) granted to an Employee who, at the time of the grant of
such Incentive Stock Option, owns stock representing more than ten percent (10%)
of the  voting  power of all  classes  of stock of the  Company or any Parent or
Subsidiary,  the per Share exercise price shall be no less than 110% of the Fair
Market Value per Share on the date of grant.

                     (B) granted to any other  Employee,  the per Share exercise
price shall be no less than 100% of the Fair Market  Value per Share on the date
of grant.

               (ii) In the case of a Nonstatutory Stock Option

                     (A)  granted to a person  who,  at the time of the grant of
such Option,  is a Named Executive of the Company,  the per share Exercise Price
shall be no less  than  100% of the fair  market  value per Share on the date of
grant.

                     (B)  granted to any other  person,  the per Share  exercise
price shall be no less than 85% of the Fair  Market  Value per Share on the date
of grant.

         (b) The  consideration  to be paid for the  Shares  to be  issued  upon
exercise of an Option,  including the method of payment,  shall be determined by
the  Administrator  (and,  in the case of an Incentive  Stock  Option,  shall be
determined  at the time of grant)  and may  consist  entirely  of (1) cash,  (2)
check,  (3)  promissory  note,  (4) other Shares which (x) in the case of Shares
acquired  upon  exercise of an Option either have been owned by the Optionee for
more than six months on the date of surrender or were not acquired,  directly or
indirectly,  from the  Company,  and (y) have a Fair Market Value on the date of
surrender  equal to the aggregate  exercise price of the Shares as to which said
Option shall be exercised, (5) authorization from the Company to retain from the
total number of Shares as to which the Option is exercised that number of Shares
having a Fair Market Value on the date of exercise  equal to the exercise  price
for the total number of Shares as to which the Option is exercised, (6) delivery
of a properly executed exercise notice together with irrevocable instructions to
a broker to promptly  deliver to the Company the amount of sale or loan proceeds
required  to  pay  the  exercise   price,   (7)  by  delivering  an  irrevocable
subscription  agreement  for the Shares which  irrevocably  obligates the option
holder to take and pay for the Shares not more than twelve months after the date
of delivery of the subscription agreement,  (8) any combination of the foregoing
methods of payment,  (9) or such other  consideration  and method of payment for
the issuance of Shares to the extent  permitted under Applicable Laws. in making
its  determination as to the type of  consideration  to accept,  the Board shall
consider if  acceptance  of such  consideration  may be  reasonably  expected to
benefit the Company.

                                      -6-



     9. Exercise of Option.

         (a) Procedure for Exercise; Rights as a Stockholder. Any Option granted
hereunder  shall be  exercisable  at such  times and under  such  conditions  as
determined  by the Board,  including  performance  criteria  with respect to the
Company and/or the Optionee,  and as shall be permissible under the terms of the
Plan.

         An Option may not be exercised for a fraction of a Share.

         An Option shall be deemed to be exercised  when written  notice of such
exercise  has been  given to the  Company  in  accordance  with the terms of the
Option by the person  entitled to exercise  the Option and full  payment for the
Shares with  respect to which the Option is exercised  has been  received by the
Company.  Full  payment  may,  as  authorized  by  the  Board,  consist  of  any
consideration  and method of payment  allowable  under Section 8(b) of the Plan.
Until the issuance (as  evidenced by the  appropriate  entry on the books of the
Company or of a duly  authorized  transfer  agent of the  Company)  of the stock
certificate evidencing such Shares, no right to vote or receive dividends or any
other rights as a  stockholder  shall exist with respect to the Optioned  Stock,
notwithstanding the exercise of the Option. The Company shall issue (or cause to
be issued)  such stock  certificate  promptly  upon  exercise of the Option.  No
adjustment  will be made for a dividend or other right for which the record date
is prior to the date the stock  certificate  is issued,  except as  provided  in
Section 13 of the Plan.

         Exercise of an Option in any manner  shall  result in a decrease in the
number of Shares which  thereafter  may be  available,  both for purposes of the
Plan and for sale  under  the  Option,  by the  number of Shares as to which the
Option is exercised.

        (b) Termination of Status as an Employee or Consultant.  In the event of
termination of an Optionee's consulting  relationship or Continuous Status as an
Employee  with the Company,  such Optionee may, but only within thirty (30) days
(or  such  other  period  of time  as is  determined  by the  Board,  with  such
determination in the case of an Incentive Stock Option being made at the time of
grant of the Option and not  exceeding  ninety (90) days) after the date of such
termination  (but in no event later than the expiration date of the term of such
Option as set forth in the Option Agreement),  exercise his or her Option to the
extent  that  Optionee  was  entitled  to  exercise  it  at  the  date  of  such
termination. To the extent that Optionee was not entitled to exercise the Option
at the date of such termination, or if Optionee does not exercise such Option to
the  extent so  entitled  within the time  specified  herein,  the Option  shall
terminate.

         (c) Disability of Optionee.  Notwithstanding  the provisions of Section
9(b) above, in the event of termination of an Optionee's Continuous Status as an
Employee or Consultant as a result of his or her total and permanent  disability
(as defined in Section 22(e)(3) of the Code), he or she may, but only within six
(6) months (or such other period of time not exceeding  twelve (12) months as is
determined  by the Board,  with such  determination  in the case of an Incentive
Stock  Option  being made at the time of grant of the  Option)  from the date of
such  termination (but in no event later than the date of expiration of the term
of such Option as set forth in the Option Agreement), exercise his or her Option
to the  extent  he or she  was  entitled  to  exercise  it at the  date  of such
termination.  To the extent  that he or she was not  entitled  to

                                      -7-



exercise  the  Option  at the  date of  termination,  or if he or she  does  not
exercise such Option (which he or she was entitled to exercise)  within the time
specified herein, the Option shall terminate.

         (d) Death of Optionee. In the event of the death of an Optionee:

               (i)  during  the term of the  Option who is at the time of his or
her death an  Employee or  Consultant  of the Company and who shall have been in
Continuous  Status as an Employee or  Consultant  since the date of grant of the
Option, the Option may be exercised, at any time within six (6) months following
the date of death (but in no event later than the date of expiration of the term
of such Option as set forth in the Option  Agreement),  by the Optionee's estate
or by a person  who  acquired  the right to  exercise  the  Option by bequest or
inheritance,  but only to the  extent of the right to  exercise  that would have
accrued had the Optionee  continued living and remained in Continuous  Status as
an Employee or Consultant six (6) months after the date of death, subject to the
limitation set forth in Section 5(b); or

               (ii) within  thirty  (30) days (or such other  period of time not
exceeding six (6) months as is determined by the Board, with such  determination
in the case of an Incentive  Stock Option being made at the time of grant of the
Option) after the termination of Continuous Status as an Employee or Consultant,
the Option may be  exercised,  at any time within six (6) months  following  the
date of death (but in no event later than the date of  expiration of the term of
such Option as set forth in the Option  Agreement),  by the Optionee's estate or
by a person  who  acquired  the  right to  exercise  the  Option by  bequest  or
inheritance, but only to the extent of the right to exercise that had accrued at
the date of termination.

         (e) Rule 16b-3.  Options granted to persons subject to Section 16(b) of
the Exchange Act must comply with Rule 16b-3 and shall  contain such  additional
conditions  or  restrictions  as may be required  thereunder  to qualify for the
maximum  exemption  from  Section 16 of the  Exchange  Act with  respect to Plan
transactions.

         (f) Buyout  Provisions.  The Administrator may at any time offer to buy
out for a payment in cash or Shares, an Option previously granted, based on such
terms and conditions as the Administrator shall establish and communicate to the
Optionee at the time that such offer is made.

     10.  Nontransferability  of Options.  The Option may not be sold,  pledged,
assigned, hypothecated,  transferred, or disposed of in any manner other than by
will or by the laws of descent or distribution;  provided that the Administrator
may in its discretion grant transferable  Nonstatutory Stock Options pursuant to
option  agreements  specifying (i) the manner in which such  Nonstatutory  Stock
Options are transferable and (ii) that any such transfer shall be subject to the
Applicable  Laws.  The  designation  of a  beneficiary  by an Optionee  will not
constitute a transfer.  An Option may be  exercised,  during the lifetime of the
Optionee, only by the Optionee or a transferee permitted by this Section 10.

     11.  Stock  Withholding  to Satisfy  Withholding  Tax  Obligations.  At the
discretion of the Administrator,  Optionees may satisfy withholding  obligations
as  provided  in this  paragraph.

                                      -8-



When an Optionee  incurs tax liability in connection  with an Option,  which tax
liability  is subject to tax  withholding  under  applicable  tax laws,  and the
Optionee is obligated to pay the Company an amount required to be withheld under
applicable tax laws, the Optionee may satisfy the  withholding tax obligation by
electing to have the Company withhold from the Shares to be issued upon exercise
of the Option  that  number of Shares  having a Fair  Market  Value equal to the
amount  required  to be  withheld.  The Fair  Market  Value of the  Shares to be
withheld  shall be  determined on the date that the amount of tax to be withheld
is to be determined (the "Tax Date").

         All  elections by an Optionee to have Shares  withheld for this purpose
shall be made in writing in a form acceptable to the  Administrator and shall be
subject to the following restrictions:

         (a) the election must be made on or prior to the applicable Tax Date;

         (b) once made,  the election  shall be irrevocable as to the particular
Shares of the Option or Right as to which the election is made; and

         (c) all elections shall be subject to the consent or disapproval of the
Administrator.

         In the  event  the  election  to  have  Shares  withheld  is made by an
Optionee  and the Tax Date is deferred  under  Section 83 of the Code because no
election is filed under  Section 83(b) of the Code,  the Optionee  shall receive
the full number of Shares with respect to which the Option is exercised but such
Optionee  shall be  unconditionally  obligated to tender back to the Company the
proper number of Shares on the Tax Date.

     12. Limitation on Grants to Employees. Subject to adjustment as provided in
this Plan,  the maximum  number of Shares which may be granted  under Options to
any  Employee  under  this  Plan for any  fiscal  year of the  Company  shall be
500,000.

     13.  Adjustments Upon Changes in Capitalization  or Merger.  Subject to any
required  action by the  stockholders  of the  Company,  the number of shares of
Common Stock covered by each outstanding  Option, the number of shares of Common
Stock which have been  authorized for issuance under the Plan but as to which no
Options  have yet been  granted  or which  have been  returned  to the Plan upon
cancellation or expiration of an Option,  the maximum number of Shares of Common
Stock for which  Options may be granted to any Employee  under Section 12 of the
Plan,  and the price per share of Common Stock covered by each such  outstanding
Option,  shall be  proportionately  adjusted for any increase or decrease in the
number of issued shares of Common Stock  resulting  from a stock split,  reverse
stock split,  stock  dividend,  combination  or  reclassification  of the Common
Stock,  or any other  increase  or  decrease  in the number of issued  shares of
Common Stock effected without receipt of consideration by the Company; provided,
however, that conversion of any convertible  securities of the Company shall not
be  deemed  to have been  "effected  without  receipt  of  consideration."  Such
adjustment shall be made by the Board, whose determination in that respect shall
be final,  binding and  conclusive.  Except as  expressly  provided  herein,  no
issuance  by the  Company  of  shares  of  stock  of any  class,  or

                                      -9-



securities  convertible into shares of stock of any class,  shall affect, and no
adjustment by reason  thereof shall be made with respect to, the number or price
of shares of Common Stock subject to an Option.

         In the event of the proposed dissolution or liquidation of the Company,
the Option will terminate immediately prior to the consummation of such proposed
action,  unless otherwise  provided by the Board. The Board may, in the exercise
of its  sole  discretion  in such  instances,  declare  that  any  Option  shall
terminate  as of a date fixed by the Board and give each  Optionee  the right to
exercise  his  Option  as to all or any part of the  Optioned  Stock,  including
Shares as to which the Option would not otherwise be  exercisable.  In the event
of a proposed sale of all or substantially all of the assets of the Company,  or
the merger of the Company with or into another corporation,  the Option shall be
assumed  or  an  equivalent  option  shall  be  substituted  by  such  successor
corporation or a parent or subsidiary of such successor corporation,  unless the
Board  determines,  in the exercise of its sole  discretion  and in lieu of such
assumption or  substitution,  that the Optionee shall have the right to exercise
the Option as to all of the  Optioned  Stock,  including  Shares as to which the
Option would not  otherwise be  exercisable.  If the Board makes an Option fully
exercisable in lieu of assumption or substitution in the event of a merger,  the
Board shall notify the Optionee that the Option shall be fully exercisable for a
period of sixty  (60) days from the date of such  notice,  and the  Option  will
terminate upon the expiration of such period.

     14. Time of Granting Options. The date of grant of an Option shall, for all
purposes,  be the  date on  which  the  Administrator  makes  the  determination
granting such Option,  or such other date as is determined by the Board.  Notice
of the  determination  shall be given to each  Employee or Consultant to whom an
Option is so granted within a reasonable time after the date of such grant.

     15. Amendment and Termination of the Plan.

         (a) Amendment and Termination.  The Board may at any time amend, alter,
suspend or  discontinue  the plan, but no amendment,  alteration,  suspension or
discontinuation  shall be made which  would  impair  the rights of any  Optionee
under any grant theretofore made,  without his or her consent.  In addition,  to
the extent  necessary and desirable to comply with Rule 16b-3 under the Exchange
Act or with Sections 162(m) and 422 of the Code (or any other  applicable law or
regulation,  including  the  requirements  of the NASD or an  established  stock
exchange),  the Company shall obtain stockholder  approval of any Plan amendment
in such a manner and to such a degree as required.

         (b)  Effect  of  Amendment  or  Termination.   Any  such  amendment  or
termination  of the Plan  shall not  affect  Options  already  granted  and such
Options  shall  remain  in full  force  and  effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Board, which agreement must be in writing and signed by the Optionee and the
Company.

     16. Conditions Upon Issuance of Shares. Shares shall not be issued pursuant
to the exercise of an Option unless the exercise of such Option and the issuance
and  delivery of such

                                      -10-



Shares  pursuant  thereto  shall  comply with all  relevant  provisions  of law,
including,  without  limitation,  the  Securities  Act of 1933, as amended,  the
Exchange  Act,  the  rules  and  regulations  promulgated  thereunder,  and  the
requirements of any stock exchange upon which the Shares may then be listed, and
shall be further subject to the approval of counsel for the Company with respect
to such compliance.

         As a condition  to the  exercise of an Option,  the Company may require
the person  exercising  such Option to represent  and warrant at the time of any
such  exercise  that the  Shares are being  purchased  only for  investment  and
without  any  present  intention  to sell or  distribute  such Shares if, in the
opinion of counsel for the Company,  such a representation is required by any of
the aforementioned relevant provisions of law.

     17. Reservation of Shares. The Company,  during the term of this Plan, will
at all  times  reserve  and keep  available  such  number  of Shares as shall be
sufficient to satisfy the requirements of the Plan.

         The inability of the Company to obtain  authority  from any  regulatory
body having jurisdiction,  which authority is deemed by the Company's counsel to
be necessary  to the lawful  issuance  and sale of any Shares  hereunder,  shall
relieve the Company of any  liability in respect of the failure to issue or sell
such Shares as to which such requisite authority shall not have been obtained.

     18.  Agreements.  Options shall be evidenced by written  agreements in such
form as the Board shall approve from time to time.

     19. Stockholder  Approval.  Approval by the stockholders of the Company was
obtained  and the Plan was  adopted  in the degree  and  manner  required  under
applicable state and federal law, provided that stockholder approval shall again
be obtained in a manner meeting the requirements of Section 162(m) of the Code.

                                      -11-






          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                        OF CELTRIX PHARMACEUTICALS, INC.
                      1997 ANNUAL MEETING OF STOCKHOLDERS

     The undersigned  stockholder of Celtrix  Pharmaceuticals,  Inc., a Delaware
corporation,  hereby  acknowledges  receipt of the  Notice of Annual  Meeting of
Stockholders and Proxy Statement,  each dated July 21, 1997, and hereby appoints
Andreas   Sommer   and  David  M.   Rosen  or  either  of  them,   proxies   and
attorneys-in-fact, with full power to each of substitution, on behalf and in the
name of the undersigned, to represent the undersigned at the 1997 Annual Meeting
of  Stockholders  of Celtrix  Pharmaceuticals,  Inc. to be held on  September 9,
1997, at 10:00 a.m., local time, at the Company's  principal  executive offices,
located  at  3055  Patrick  Henry  Drive,  Santa  Clara,  California  and at any
adjournment(s)  thereof,  and to vote all  shares  of  Common  Stock  which  the
undersigned would be entitled to vote if then and there personally  present,  on
the matters set forth on the reverse side.

     THIS  PROXY  WILL BE VOTED AS  DIRECTED  OR, IF NO  CONTRARY  DIRECTION  IS
INDICATED,  WILL BE VOTED AS FOLLOWS: (1) FOR THE ELECTION OF DIRECTORS; (2) FOR
THE  APPROVAL OF AN  AMENDMENT  TO INCREASE  THE  NUMBER OF SHARES  RESERVED FOR
ISSUANCE UNDER THE COMPANY'S  1991 STOCK OPTION PLAN BY 1,500,000  SHARES AND TO
PERMIT  NONEMPLOYEE  DIRECTORS  OF THE COMPANY TO BE  ELIGIBLE TO RECEIVE  STOCK
OPTIONS UNDER THE PLAN, (3) FOR  RATIFICATION OF THE APPOINTMENT OF ERNST& YOUNG
LLP AS  INDEPENDENT  AUDITORS,  AND (4) AS SAID PROXIES  DEEM  ADVISABLE ON SUCH
OTHER  MATTERS AS MAY  PROPERLY  COME BEFORE THE MEETING AND ANY  ADJOURNMENT(S)
THEREOF.

                                                  CELTRIX PHARMACEUTICALS, INC.
                                                  P.O. BOX 11247
                                                  NEW YORK, N.Y. 10203-0247

(Continued, and to be dated and signed on the reverse side.)



[   ]

1. ELECTION OF DIRECTORS:

FOR all nominees        WITHHOLD authority to vote
listed below   [ X ]    for all nominees listed below. [ X ]   EXCEPTIONS* [ X ]

Nominees: Henry E. Blair; Andreas Sommer, Ph.D.; James E. Thomas

(INSTRUCTIONS:  To withhold authority to vote for any individual  nominee,  mark
the "Exceptions" box and write that nominee's name in the space provided below.)

*Exceptions ____________________________________________________________________

2.  PROPOSAL TO APPROVE AN  AMENDMENT TO THE 1991 STOCK
OPTION PLAN TO INCREASE  THE NUMBER OF SHARES OF COMMON
STOCK  RESERVED  FOR ISSUANCE  THEREUNDER  BY 1,500,000
SHARES  AND  TO  PERMIT  NONEMPLOYEE   MEMBERS  OF  THE
COMPANY'S  BOARD OF DIRECTORS TO BE ELIGIBLE TO RECEIVE
STOCK OPTIONS UNDER THE 1991 STOCK OPTION PLAN.

FOR  [ X ]        AGAINST  [ X ]        ABSTAIN  [ X ]

3. PROPOSAL TO RATIFY  APPOINTMENT OF ERNST & YOUNG LLP
AS THE  INDEPENDENT  AUDITORS  OF THE  COMPANY  FOR THE
FISCAL YEAR ENDING MARCH 31, 1998.

FOR  [ X ]        AGAINST  [ X ]        ABSTAIN  [ X ]

4. SUCH OTHER  MATTERS AS MAY PROPERLY  COME BEFORE THE
MEETING AND ANY ADJOURNMENT(S) THEREOF.

                                                       Address Change
                                                       and/or Comments  [ X ]

                                           (This Proxy should be marked,  dated,
                                           signed by the stockholder(s)  exactly
                                           as his or her  name  appears  hereon,
                                           and returned promptly in the enclosed
                                           envelope.   Persons   signing   in  a
                                           fiduciary    capacity    should    so
                                           indicate. If shares are held by joint
                                           tenants  or  as  community  property,
                                           both should sign.)

                                           Dated: ________________________, 1997

                                           _____________________________________
                                                       Signature
                                           _____________________________________
                                                       Signature

                                           Votes MUST be indicated
                                          (x) in Black or Blue ink.   [ X ]

Sign, Date and Return the Proxy Card Promptly Using the Enclosed Envelope.