WELLS FARGO BANK                                   REVOLVING LINE OF CREDIT NOTE
- --------------------------------------------------------------------------------

$3,000,000.00                                                Oakland, California
                                                             November 30, 1997

     FOR VALUE RECEIVED,  the undersigned  CHOLESTECH  CORPORATION  ("Borrower")
promises to pay to the order of WELLS FARGO BANK, NATIONAL  ASSOCIATION ("Bank")
at its office at East Bay RCBO, One Kaiser Plaza Suite 850,  Oakland,  CA 94612,
or at such other place as the holder  hereof may  designate,  in lawful money of
the United States of America and in immediately  available  funds, the principal
sum of $3,000,000.00,  or so much thereof as may be advanced and be outstanding,
with  interest  thereon,  to be  computed on each  advance  from the date of its
disbursement as set forth herein.

INTEREST:

     (a) Interest.  The  outstanding  principal  balance of this Note shall bear
interest  (computed on the basis of a 360-day  year,  actual days  elapsed) at a
rate per annum equal to the Prime Rate in effect  from time to time.  The "Prime
Rate" is a base rate that Bank from time to time establishes and which serves as
the basis upon which  effective rates of interest are calculated for those loans
making reference  thereto.  Each change in the rate of interest  hereunder shall
become effective on the date each Prime Rate change is announced within Bank.

     (b) Payment of Interest.  Interest accrued on this Note shall be payable on
the last day of each month, commencing December 31, 1997.

     (c) Default  Interest.  From and after the maturity  date of this Note,  or
such earlier date as all principal  owing  hereunder  becomes due and payable by
acceleration or otherwise,  the outstanding principal balance of this Note shall
bear interest until paid in full at an increased rate per annum (computed on the
basis of a 360-day  year,  actual  days  elapsed)  equal to 4% above the rate of
interest from time to time applicable to this Note.

     (d)  Collection  of  Payments.  Borrower  authorizes  Bank to  collect  all
interest and fees due hereunder by charging  Borrower's  demand deposit  account
number  4187-516166 with Bank, or any other demand deposit account maintained by
any  Borrower  with  Bank,  for  the  full  amount  thereof.   Should  there  be
insufficient  funds in any such demand deposit account to pay all such sums when
due, the full amount of such deficiency  shall be immediately due and payable by
Borrower.

BORROWING AND REPAYMENT:

     (a) Borrowing and Repayment. Borrower may from time to time during the term
of this Note borrow,  partially or wholly repay its outstanding borrowings,  and
reborrow,  subject to all of the limitations,  terms and conditions of this Note
and of any document executed in connection with or governing this Note; provided
however, that the total outstanding  borrowings under this Note shall not at any
time exceed the principal amount stated above.  The unpaid principal  balance of
this obligation at any time shall be the total amounts advanced hereunder by the
holder  hereof less the amount of principal  payments  made hereon by or for any
Borrower,  which balance may be endorsed hereon from time to time by the holder.
The outstanding  principal balance of this Note shall be due and payable in full
on November 30, 1998.

     (b) Advances. Advances hereunder, to the total amount of the principal surm
available hereunder, may be made by the holder at the oral or written request of
(i) WARREN PINCKERT and/or ANDREA TILLER and/or CEClLIA AGUILAR,  any two acting
together who are  authorized to request  advances and direct the  disposition of
any avances until written notice of the revocation of such authority is received
by the holder at the office designated  above, or (ii) any person,  with respect
to  advances  deposited  to the credit of any account of any  Borrower  with the
holder,  which advances,  when so deposited,  shall be conclusively  presumed to
have been made to or for the  benefit of each  Borrower  regardless  of the fact
that persons other than those  authorized to request advances may have authority
to draw against such  account.  The holder shall have no obligation to determine
whether  any  person  requesting  an advance  is or has been  authorized  by any
Borrower.

     (c)  Application  of  Payments.  Each  payment  made on this Note  shall be
credited  first,  to any  interest  then  due  and  second,  to the  outstanding
principal balance hereof.

EVENTS OF DEFAULT:

The  occurrence of any of the following  shall  constitute an "Event of Default"
under this Note:

     (a) The failure to pay any principal,  interest, fees or other charges when
due  hereunder  or under  any  contract,  instrument  or  document  executed  in
connection with this Note.

     (b) The filing of a petition by or against any  Borrower,  any guarantor of
this Note or any general  partner or joint  venturer in any Borrower  which is a
partnership or a joint venture (with each such guarantor, general partner and/or
joint  venturer  referred  to  herein  as a "Third  Party  Obligor")  under  any
provisions of the Bankruptcy  Reform Act, Title 11 of the United States Code, as
amended  or  recodified  from time to time,  or under any  similar  or other law
relating to bankruptcy, insolvency,  reorganization or other relief for debtors;
the  appointment of a receiver,  trustee,  custodian or liquidator of or for any
part of the assets or property  of any  Borrower  or Third  Party  Obligor;  any
Borrower or Third Party Obligor becomes  insolvent,  makes a general  assignment
for the benefit of creditors or is generally not paying its debts as they become
due; or any  attachment  or like levy on any  property of any  Borrower or Third
Party Obligor.





     (c) The death or  incapacity  of any  individual  Borrower  or Third  Party
Obligor,  or the  dissolution  or  liquidation  of any  Borrower  or Third Party
Obligor  which is a  corporation,  partnership,  joint  venture or other type of
entity.

     (d) Any default in the payment or  performance  of any  obligation,  or any
defined event of default,  under any  provisions of any contract,  instrument or
document  pursuant to which any Borrower or Third Party Obligor has incurred any
obligation for borrowed money, any purchase  obligation,  or any other liability
of any kind to any person or entity, including the holder.

     (e) Any financial statement provided by any Borrower or Third Party Obligor
to Bank proves to be incorrect, false or misleading in any material respect.

     (f) Any sale or transfer of all or a  substantial  or material  part of the
assets of any Borrower or Third Party Obligor other than in the ordinary  course
of its business.

     (g) Any  violation or breach of any  provision  of, or any defined event of
default  under,  any  addendum  to this  Note or any loan  agreement,  guaranty,
security  agreement,  deed of trust,  mortgage  or other  document  executed  in
connection with or securing this Note.

MISCELLANEOUS:

     (a) Remedies.  Upon the  occurrence of any Event of Default,  the holder of
this Note,  at the  holder's  option,  may  declare  all sums of  principal  and
interest  outstanding  hereunder  to be  immediately  due  and  payable  without
presentment,  demand,  notice of nonperformance,  notice of protest,  protest or
notice of dishonor,  all of which are expressly waived by each Borrower, and the
obligation,  if any, of the holder to extend any further credit  hereunder shall
immediately  cease  and  terminate.  Each  Borrower  shall  pay  to  the  holder
immediately  upon demand the full  amount of all  payments,  advances,  charges,
costs and expenses,  including  reasonable  attorneys'  fees (to include outside
counsel fees and all allocated costs of the holder's in-house counsel), expended
or incurred by the holder in  connection  with the  enforcement  of the holder's
rights and/or the collection of any amounts which become due to the holder under
this Note,  and the  prosecution  or defense of any action in any way related to
this Note,  including  without  limitation,  any action for declaratory  relief,
whether incurred at the trial or appellate  level, in an arbitration  proceeding
or otherwise, and including any of the foregoing incurred in connection with any
bankruptcy proceeding  (including without limitation,  any adversary proceeding,
contested  matter or motion brought by Bank or any other person) relating to any
Borrower or any other person or entity.

     (b)  Obligations  Joint and Several.  Should more than one person or entity
sign this Note as a Borrower,  the  obligations  of each such Borrower  shall be
joint and several.

     (c)  Goveminq  Law.  This  Note  shall  be  governed  by and  construed  in
accordance with the laws of the state of California.


     IN WITNESS  WHEREOF,  the undersigned has executed this Note as of the date
first written above.

CHOLESTECH CORPORATION


By: /s/ Warren Pinckert
   ---------------------------
   WARREN PINCKERT
   PRESIDENT




                               November 30, 1997

Warren Pinckert, President
Cholestech Corporation
3347 Investment Blvd.
Hayward, CA. 94545

Dear Mr. Pinckert:

     This letter is to confirm the changes agreed upon between Wells Fargo Bank,
National  Association  ("Bank") and Cholestech  Corporation  ("Borrower") to the
terms and conditions of that certain letter agreement  between Bank and Borrower
dated as of November 19, 1996,  as amended from time to time (the  "Agreement").
For  valuable  consideration,  the receipt and  sufficiency  of which are hereby
acknowledged, Bank and Borrower hereby agree that the Agreement shall be amended
as follows to reflect said changes.

     1. The Agreement is hereby  amended by deleting  "November 30, 1997" as the
last day on which  Bank will make  advances  under  the Line of  Credit,  and by
substituting for said date "November 30, 1998," with such change to be effective
upon the execution and delivery to Bank of a promissory  note  substantially  in
the form of Exhibit A attached  hereto (which  promissory note shall replace and
be deemed the Line of Credit Note defined in and made pursuant to the Agreement)
and all other contracts,  instruments and documents required by Bank to evidence
such change.

     2. Except as specifically  provided herein, all terms and conditions of the
Agreement remain in full force and effect,  without waiver or modification.  All
terms  defined in the  Agreement  shall have the same  meaning when used herein.
This letter and the Agreement shall be read together, as one document.

     3. Borrower hereby remakes all representations and warranties  contained in
the Agreement and reaffirms all covenants set forth  therein.  Borrower  further
certifies that as of the date of Borrower's acknowledgment set forth below there
exists no  default  or  defined  event of  default  under the  Agreement  or any
promissory note or other contract, instrument or document executed in connection
therewith, nor any condition, act or event



Cholestech Corporation
November 30, 1997
Page 2

which with the giving of notice or the passage of time or both would  constitute
such a default or defined event of default.

     Your  acknowledgment  of this letter  shall  constitute  acceptance  of the
foregoing terms and conditions.

                                   Sincerely,


                                   WELLS FARGO BANK,
                                    NATIONAL ASSOCIATION


                                   By:  /s/ Patricia L. Dorsey
                                       ------------------------
                                       PATRICIA L. DORSEY
                                       VICE PRESIDENT


Acknowledged and accepted as of December 1, 1997:

By: /s/ Warren Pinckert
   ----------------------
   WARREN PINCKERT
   PRESIDENT



                                            SECURITIES ACCOUNT CONTROL AGREEMENT
WELLS FARGO BANK                                 (Wells Fargo Bank Intermediary)
- --------------------------------------------------------------------------------


THIS SECURITIES  ACCOUNT CONTROL AGREEMENT (this "Agreement") is entered into as
of November 30, 1997, by and among CHOLESTECH  CORPORATION  ("Customer"),  WELLS
FARGO BANK (TEXAS),  NATIONAL  ASSOCIATION,  acting through its Investment Group
("Intermediary"), and WELLS FARGO BANK, NATIONAL ASSOCIATION, acting through its
East Bay RCBO Office ("Secured Party").

                                    RECITALS

     A.  Customer  maintains  that  certain  INVESTMENT  MANAGEMENT  Account No.
358210114 (the "Securities  Account") with Intermediary pursuant to an agreement
between  Intermediary and Customer dated as of December 2, 1996, and governed by
the laws of the State of California (the "Account Agreement"),  and Customer has
granted to Secured Party a security  interest in the Securities  Account and all
financial  assets and other  property now or at any time  hereafter  held in the
Securities Account. Security interest limited to $3,000,000 plus interest.

     B. Secured Party,  Customer and Intermediary have agreed to enter into this
Agreement to perfect Secured Party's  security  interests in the Collateral,  as
defined below.

NOW,  THEREFORE,  in consideration  of their mutual covenants and promises,  the
parties agree as follows:

     1. DEFINITIONS. As used herein:

     (a) the term "Collateral" shall mean: (i) the Securities Account;  (ii) all
financial  assets  credited  to  the  Securities  Account;  (iii)  all  security
entitlements  with respect to the financial  assets  credited to the  Securities
Account;  (iv) any and all other  investment  property or assets  maintained  or
recorded in the Securities Account;  and (v) all substitutions for, and proceeds
of the sale or other  disposition  of, any of the foregoing,  including  without
limitation, cash proceeds; and

     (b) the terms "investment property," "entitlement order," "financial asset"
and "security  entitlement" shall have the respective  meanings set forth in the
California  Uniform Commerical Code. The parties hereby expressly agree that all
property, including without limitation, cash, certificates of deposit and mutual
funds,  at any  time  held  in the  Securities  Account  is to be  treated  as a
"financial asset".

     2. AGREEMENT FOR CONTROL. Intermediary is authorized by Customer and agrees
to comply with all entitlement  orders  originated by Secured Party with respect
to the Securities  Account,  and all other requests or instructions from Secured
Party regarding  disposition and/or delivery of the Collateral,  without further
consent or direction from Customer or any other party.

     3. CUSTOMER'S RIGHTS WITH RESPECT TO THE COLLATERAL.

     (a)  Until  Intermediary  is  notified  otherwise  by  Secured  Party:  (i)
Customer,  or any party  authorized  by Customer to advise or otherwise act with
respect to the Securities Account, may give trading instructions to Intermediary
with respect to Collateral in the Securities Account;  and (ii) Intermediary may
distribute  to  Customer  or any  other  party  in  accordance  with  Customer's
directions that portion of the Collateral which consists of interest and/or cash
dividends earned on financial assets maintained in the Securities Account.

     (b) Without  Secured  Party's prior written  consent,  except to the extent
permitted by Section 3(a) hereof:  (i) neither Customer nor any party other than
Secured Party may withdraw any Collateral from the Securities Account;  and (ii)
Intermediary  will not comply with any entitlement  order or request to withdraw
any Collateral from the Securities Account given by any party other than Secured
Party.

     (c) Upon receipt of either written or oral notice from Secured  Party:  (i)
Intermediary  shall promptly cease complying with  entitlement  orders and other
instructions  concerning the Collateral,  including the Securities Account, from
all parties other than Secured Party; and (ii)  Intermediary  shall not make any
further  distributions  of any Collateral to any party other than Secured Party,
nor permit any further voluntary changes in the financial assets.

     4. INTERMEDIARY'S ACKNOWLEDGMENTS. Intermediary acknowledges that:

     (a) The  Securities  Account  is  maintained  with  Intermediary  solely in
Customer's name.

     (b) Intermediary has no knowledge of any claim to, security  interest in or
lien upon any of the Collateral,  except: (i) the security interests in favor of
Secured  Party;  and (ii)  Intermediary's  liens  securing fees and charges,  or
payment for open trade commitments, as described in Section 4(c) hereof.

     (c) Any claim to,  security  interest in or lien upon any of the Collateral
which Intermediary now has or at any time hereafter acquires shall be junior and
subordinate to the security interests of Secured Party in the Collateral, except
for  Intermediary's  liens securing:  (i) fees and charges owed by Customer with
respect to the  operation of the  Securities  Account;  and (ii) payment owed to
Intermediary for open trade  commitments for purchases in and for the Securities
Account.

     5. AGREEMENTS OF INTERMEDIARY AND CUSTOMER. Intermediary and Customer agree
that:

     (a)  Intermediary  shall flag its  books,  records  and  systems to reflect
Secured Party's security  interests in the Collateral,  and shall provide notice
thereof to any party making inquiry as to Customer's  accounts with Intermediary
to whom Intermediary is legally required or permitted to provide information.

     (b)  Intermediary  shall  send  copies of all  statements  relating  to the
Securities Account simultaneously to Customer and Secured Party.

     (c)  Intermediary  shall  promptly  notify Secured Party if any other party
asserts any claim to,  security  interest in or lien upon any of the Collateral,
and  Intermediary  shall not enter into any control,  custodial or other similar
agreement with any other party that would create or acknowledge the existence of
any such other claim, security interest or lien.

     (d)  Without  Secured  Party's  prior  written  consent,  Intermediary  and
Customer shall not amend, modify or terminate the Account Agreement, other than:
(i) amendments to reflect ordinary and reasonable changes in Intermediary's fees
and charges for handling the Securities  Account;  and (ii) operational  changes
initiated by  Intermediary  as long as they do not alter any of Secured  Party's
rights hereunder.

     6. MISCELLANEOUS.

     (a) This Agreement shall not create any obligation or duty  of Intermediary
except as expressly set forth herein.

     (b) In the event of any  conflict  between this  Agreement  and the Account
Agreement or any other agreement between Intermediary and Customer, the terms of
this Agreement shall control.

     (c) All notices,  requests  and demands  which any party is required or may
desire to give to any other party under any provision of this  Agreement must be
in writing (unless otherwise  specifically provided) and delivered to each party
at the address or  facsimile  number set forth below its  signature,  or to such
other address or facsimile  number as any party may designate by written  notice
to all other parties. Each such notice, request and demand shall be deemed given
or made as follows: (i) if sent by hand delivery, upon delivery; (ii) if sent by
facsimile, upon receipt; and (iii) if sent by mail, upon the earlier of the date
of receipt or 3 days after  deposit in the U.S.  mail,  first  class and postage
prepaid.

     (d) This  Agreement  shall be binding  upon and inure to the benefit of the
heirs, executors, administrators, legal representatives,  successors and assigns
of the parties. This Agreement may be amended or modified only in writing signed
by all parties hereto.

     (e) This Agreement shall terminate upon  Intermediary's  receipt of written
notice from Secured Party expressly  stating that Secured Party no longer claims
any security interest in the Collateral.

     (f) This  Agreement  shall be governed by and construed in accordance  with
the laws of the State of California.

                     SEE PAGE 3 OF AGREEMENT FOR SIGNATURES



IN WITNESS  WHEREOF,  the parties have  executed  this  Agreement as of the date
first set forth above.

WELLS FARGO BANK (TEXAS),                       WELLS FARGO BANK,
NATIONAL ASSOCIATION,                           NATIONAL ASSOCIATION,
acting through its                              acting through its
Investment Group                                East Bay RCBO Office         

By:                                             By: /s/ Patricia L. Dorsey
   ----------------------------                    ----------------------------
    ROD OCMOND
    ACCOUNT ADMINISTRATOR                       Title: Vice President
                                                      -------------------------
By:                                            
   ----------------------------                
    JOHN VASCONCELLOS
    VICE PRESIDENT

Address:  525 MARKET STREET, 10TH FL.       Address: One Kaiser Plaza Suite 850 
          SAN FRANCISCO, CA 94105                    Oakland, CA 94612          
                                                                                
FAX No.:  (415) 396-7179                    FAX No.: (510) 839-2296             
                                                                                

CHOLESTECH CORPORATION

By: /s/ Warren Pinckert
   -----------------------
    WARREN PINCKERT 
    PRESIDENT


Address: 3347 INVESTMENT BLVD. 
         HAYWARD, CA 94545-3808

FAX No.: (510) 732-7227



               ADDENDUM TO SECURITY AGREEMENT: SECURITIES ACCOUNT

     THIS  ADDENDUM  is  attached  to and made a part of that  certain  Security
Agreement: Securities Account executed by CHOLESTECH  CORPORATION  ("Debtor") in
favor of WELLS FARGO BANK, NATIONAL ASSOCIATION  ("Bank"),  dated as of November
30, 1997 (the "Agreement ").

     The following provisions are hereby incorporated into the Agreement:

     1.  Securities  Account  Activity.  So long as no Event of Default  exists,
Debtor,  or any party authorized by Debtor to act with respect to the Securities
Account,  may (a) receive  payments of interest and/or cash dividends  earned on
financial assets maintained in the Securities  Account,  and (b) trade financial
assets  maintained  in the  Securities  Account.  Without  Bank's prior  written
consent,  except as permitted by the preceding sentence,  neither Debtor nor any
party other than Bank may withdraw or receive any distribution of any Collateral
from the  Securities  Account.  The Collateral  Value of the Securities  Account
shall at all times be equal to or greater than $3,000,000.00.  In the event that
the Collateral Value of the Securities Account should, for any reason and at any
time, be less than the required  amount,  Debtor shall promptly make a principal
reduction on the Indebtedness, or deposit into the Securities Account additional
assets, of a nature  satisfactory to Bank, in either case,  sufficient such that
the Collateral Value of the Securities Account achieves the required amount.

     2.  "Collateral  Value of the Securities  Account" means the percentage set
forth below for each type of investment  property held in the Securities Account
at the time of computation:

         (a)   100% of the face amount of cash and cash equivalents;

         (b)   90% of the market value of  obligations  of the United  States of
               America, but not to exceed the face amount;

         (c)   90% of the market value of commercial  paper rated at least A1 by
               a nationally recognized rating agency, but not to exceed the face
               amount;

         (d)   85%  of  the  market  value  of  corporate  and  municipal  bonds
               (excluding  convertible  bonds) rated at least AA by a nationally
               recognized rating agency, but not to exceed the face amount;

         (e)   75%  of  the  market  value  of  corporate  and  municipal  bonds
               (excluding  convertible  bonds and those  described in (d) above)
               rated at least BBB by a nationally



               recognized rating agency, but not to exceed the face amount;

with market value, in all instances,  determined by Bank in its sole discretion,
and excluding from such computation all WF Securities and Common Trust Funds.

     3.  Exclusion  from  Collateral.  Notwithstanding  anything  herein  to the
contrary,  the  terms  "Collateral"  and  "Proceeds"  do not  include,  and Bank
disclaims a security interest in all WF Securities and Common Trust Funds now or
hereafter maintained in the Securities Account.

     4.  "Common  Trust  Funds"  means common trust funds as described in 12 CFR
9.18 and includes, without limitation, common trust funds maintained by Bank for
the exclusive use of its fiduciary clients.

     5. "WF Securities" means stock,  securities or obligations of Wells Fargo &
Company or of any affiliate thereof (as the term affiliate is defined in Section
23A of the Federal Reserve Act (12 USC 371(c), as amended from time to time).

     IN WITNESS WHEREOF,  this Addendum has been executed as of the same date as
the Agreement.

CHOLESTECH CORPORATION                   WELLS FARGO BANK                 
                                               NATIONAL ASSOCITATION      

By: /s/ Warren Pinckert                  By: /s/ Patricia L. Dorsey     
    ---------------------------             ----------------------------
    Warren Pinckert                         Patricia L. Dorsey     
    President                               Vice President         
                                                   
                                                   
                                      -2-


                                                              SECURITY AGREEMENT
WELLS FARGO BANK                                              SECURITIES ACCOUNT
- --------------------------------------------------------------------------------

     1. GRANT OF SECURITY INTEREST. For valuable consideration,  the undersigned
CHOLESTECH CORPORATION,  or any of them ("Debtor"),  hereby grants and transfers
to WELLS FARGO BANK,  NATIONAL  ASSOCIATION  ("Bank") a security interest in (a)
Debtor's INVESTMENT  MANAGEMENT Account No. 358210114 (the "Securities Account")
maintained with WELLS FARGO BANK (TEXAS),  NATIONAL ASSOCIATION,  acting through
its Investment Group ("Intermediary"),  (b) all financial assets credited to the
Securities Account, (c) all security  entitlements with respect to the financial
assets credited to the Securities Account,  and (d) any and all other investment
property or assets  maintained or recorded in the  Securities  Account (with all
the foregoing defined as "Collateral"),  together with whatever is receivable or
received  when any of the  Collateral or proceeds  thereof are sold,  collected,
exchanged or otherwise  disposed of,  whether such  disposition  is voluntary or
involuntary,  including without limitation, (i) all rights to payment, including
returned  premiums,  with  respect  to  any  insurance  relating  to  any of the
foregoing,  (ii) all  rights  to  payment  with  respect  to any cause of action
affecting  or  relating  to any of the  foregoing,  and (iii) all stock  rights,
rights to  subscribe,  stock  splits,  liquidating  dividends,  cash  dividends,
dividends  paid in stock,  new  securities  or other  property of any kind which
Debtor is or may  hereafter be entitled to receive on account of any  securities
pledged hereunder, including without limitation, stock received by Debtor due to
stock splits or  dividends  paid in stock or sums paid upon or in respect of any
securities  pledged  hereunder upon the liquidation or dissolution of the issuer
thereof (hereinafter called "Proceeds"). Except as otherwise expressly permitted
herein,  in the event Debtor  receives any such  Proceeds,  Debtor will hold the
same in trust on  behalf  of and for the  benefit  of Bank and will  immediately
deliver  all  such  Proceeds  to Bank  in the  exact  form  received,  with  the
endorsement of Debtor if necessary and/or appropriate  undated stock powers duly
executed in blank, to be held by Bank as part of the Collateral,  subject to all
terms  hereof.  As used herein,  the terms  "security  entitlement,"  "financial
asset" and "investment property" shall have the respective meanings set forth in
the California  Uniform  Commercial Code.  Security  Interest limited  3,000,000
principal plus interest.

     2. OBLIGATIONS  SECURED. The obligations secured hereby are the payment and
performance  of: (a) all present and future  Indebtedness of Debtor to Bank; (b)
all obligations of Debtor and rights of Bank under this  Agreement;  and (c) all
present  and  future  obligations  of  Debtor to Bank of other  kinds.  The word
"Indebtedness" is used herein in its most  comprehensive  sense and includes any
and all advances,  debts, obligations and liabilities of Debtor, or any of them,
heretofore,  now or hereafter made,  incurred or created,  whether  voluntary or
involuntary and however arising, whether due or not due, absolute or contingent,
liquidated or unliquidated,  determined or undetermined,  and whether Debtor may
be liable  individually or jointly,  or whether recovery upon such  Indebtedness
may be or hereafter becomes unenforceable.

     3.  TERMINATION.  This Agreement will terminate upon the performance of all
obligations of Debtor to Bank, including without limitation,  the payment of all
Indebtedness  of Debtor to Bank, and the  termination of all commitments of Bank
to extend credit to Debtor,  existing at the time Bank receives  written  notice
from Debtor of the termination of this Agreement.

     4. OBLIGATIONS OF BANK. Bank shall have no duty to take any steps necessary
to preserve  the rights of Debtor  against  prior  parties,  or to initiate  any
action to protect  against the  possibility  of a decline in the market value of
the Collateral or Proceeds.  Bank shall not be obligated to take any action with
respect to the Collateral or Proceeds requested by Debtor unless such request is
made in writing and Bank determines, in its sole discretion,  that the requested
action  would  not  unreasonably  jeopardize  the  value of the  Collateral  and
Proceeds as security for the Indebtedness.

     5.  REPRESENTATIONS AND WARRANTIES.  Debtor represents and warrants to Bank
that: (a) Debtor is the sole owner of the  Collateral  and Proceeds;  (b) Debtor
has the right to grant a security  interest in the Collateral and Proceeds;  (c)
all  Collateral  and  Proceeds  are genuine,  free from liens,  adverse  claims,
setoffs, default,  prepayment,  defenses and conditions precedent of any kind or
character,  except the lien created hereby or as otherwise agreed to by Bank, or
heretofore disclosed by Debtor to Bank, in writing; (d) all statements contained
herein and, where  applicable,  in the Collateral,  are true and complete in all
material respects;  (e) no financing statement covering any of the Collateral or
Proceeds, and naming any secured party other than Bank, is on file in any public
office; (f) no person or entity,  other than Debtor, Bank and Intermediary,  has
any  interest  in or control  over the  Collateral;  and (g)  specifically  with
respect  to  Collateral  and  Proceeds  consisting  of  investment   securities,
instruments, chattel paper, documents, contracts, insurance policies or any like
property,  (i) all persons  appearing to be obligated thereon have authority and
capacity  to  contract  and are bound as they  appear  to be,  and (ii) the same
comply with applicable laws concerning  form,  content and manner of preparation
and execution.

     6. COVENANTS OF DEBTOR.

     (a) Debtor Agrees in general:  (i) to pay Indebtedness  secured hereby when
due; (ii) to indemnify Bank against all losses, claims, demands, liabilities and
expenses of every kind caused by property subject hereto; (iii) to pay all costs
and expenses,  including  reasonable  attorneys'  fees,  incurred by Bank in the
perfection and  preservation of the Collateral or Bank's interest therein and/or
the realization,  enforcement and exercise of Bank's rights, powers and remedies
hereunder;  (iv) to permit  Bank to  exercise  its  powers;  (v) to execute  and
deliver such documents as Bank deems  necessary to create,  perfect and continue
the security  interests  contemplated  hereby;  and (vi) not to change its chief
place of business (or personal  residence,  if  applicable)  or the places where
Debtor keeps any of the Collateral or Debtor's records concerning the Collateral
and Proceeds  without  first giving Bank written  notice of the address to which
Debtor is moving same.



     (b) Debtor agrees with regard to the Collateral  and Proceeds,  unless Bank
agrees otherwise in writing:  (i) not to permit any security interest in or lien
on the Collateral or Proceeds, except in favor of Bank and except liens in favor
of Intermediary to the extent expressly  permitted by Bank in writing;  (ii) not
to  hypothecate  or  permit  the  transfer  by  operation  of  law of any of the
Collateral  or Proceeds or any interest  therein;  (iii) to keep,  in accordance
with generally  accepted  accounting  principles,  complete and accurate records
regarding all  Collateral  and Proceeds,  and to permit Bank to inspect the same
and make copies  thereof at any reasonable  time;  (iv) if requested by Bank, to
receive and use reasonable  diligence to collect  Proceeds,  in trust and as the
property of Bank,  and to immediately  endorse as  appropriate  and deliver such
Proceeds  to Bank daily in the exact form in which  they are  received  together
with a collection  report in form  satisfactory  to Bank;  (v) in the event Bank
elects to receive payments of Proceeds  hereunder,  to pay all expenses incurred
by  Bank  in   connection   therewith,   including   expenses   of   accounting,
correspondence,  collection  efforts,  filing,  recording,  record  keeping  and
expenses incidental  thereto;  (vi) to provide any service and do any other acts
which may be necessary to keep all Collateral and Proceeds free and clear of all
defenses,  rights of offset and  counterclaims;  and (vii) if the  Collateral or
Proceeds  consists of securities and so long as no Event of Default  exists,  to
vote said  securities  and to give  consents,  waivers  and  ratifications  with
respect  thereto,  provided  that no vote  shall be cast or  consent,  waiver or
ratification  given or action taken which would impair  Bank's  interests in the
Collateral  and Proceeds or be  inconsistent  with or violate any  provisions of
this  Agreement.  Debtor  further  agrees  that  any  party  now or at any  time
hereafter  authorized  by Debtor to advise or otherwise  act with respect to the
Securities Account shall be subject to all terms and conditions contained herein
and in any control,  custodial or other similar  agreement at any time in effect
among Bank, Debtor and Intermediary relating to the Collateral.

     7.  POWERS  OF BANK.  Debtor  appoints  Bank its true  attorney-in-fact  to
perform any of the  following  powers,  which are coupled with an interest,  are
irrevocable  until  termination of this Agreement and may be exercised from time
to time by Bank's officers and employees,  or any of them, whether or not Debtor
is in default:  (a) to perform any  obligation  of Debtor  hereunder in Debtor's
name  or  otherwise;  (b) to  notify  any  person  obligated  on  any  security,
instrument  or  other  document  subject  to this  Agreement  of  Bank's  rights
hereunder;  (c) to collect by legal  proceedings  or  otherwise  all  dividends,
interest, principal or other sums now or hereafter payable upon or on account of
the  Collateral or Proceeds;  (d) to enter into any  extension,  reorganization,
deposit,  merger or consolidation  agreement, or any other agreement relating to
or affecting the Collateral or Proceeds,  and in connection therewith to deposit
or surrender control of the Collateral and Proceeds, to accept other property in
exchange for the  Collateral  and Proceeds,  and to do and perform such acts and
things as Bank may deem proper,  with any money or property received in exchange
for  the  Collateral  or  Proceeds,  at  Bank's  option,  to be  applied  to the
Indebtedness or held by Bank under this Agreement; (e) to make any compromise or
settlement  Bank deems  desirable  or proper in respect  of the  Collateral  and
Proceeds;  (f) to insure,  process and preserve the Collateral and Proceeds; (g)
to exercise  all rights,  powers and remedies  which Debtor would have,  but for
this Agreement,  with respect to all Collateral and Proceeds subject hereto; and
(h) to do all acts and things and execute all documents in the name of Debtor or
otherwise, deemed by Bank as necessary, proper and convenient in connection with
the preservation,  perfection or enforcement of its rights hereunder.  To effect
the purposes of this Agreement or otherwise upon  instructions of Debtor, or any
of them,  Bank may cause any  Collateral  and/or  Proceeds to be  transferred to
Bank's name or the name of Bank's  nominee.  If an Event of Default has occurred
and  is  continuing,  any  or  all  Collateral  and/or  Proceeds  consisting  of
securities  may be  registered,  without  notice,  in the  name  of  Bank or its
nominee,  and thereafter Bank or its nominee may exercise,  without notice,  all
voting and  corporate  rights at any meeting of the  shareholders  of the issuer
thereof,  any and all rights of  conversion,  exchange or  subscription,  or any
other  rights,  privileges  or  options  pertaining  to such  Collateral  and/or
Proceeds,  all as if it were the absolute  owner  thereof.  The foregoing  shall
include,  without limitation,  the right of Bank or its nominee to exchange,  at
its  discretion,  any  and all  Collateral  and/or  Proceeds  upon  the  merger,
consolidation,  reorganization,  recapitalization  or other  readjustment of the
issuer thereof, or upon the exercise by the issuer thereof or Bank of any right,
privilege or option  pertaining to any shares of the Collateral and/or Proceeds,
and in connection therewith, the right to deposit and deliver any and all of the
Collateral  and/or  Proceeds with any  committee,  depository,  transfer  agent,
registrar or other designated  agency upon such terms and conditions as Bank may
determine.  All of the foregoing rights,  privileges or options may be exercised
without  liability  on the part of Bank or its  nominee  except to  account  for
property  actually  received by Bank. Bank shall have no duty to exercise any of
the  foregoing,  or any other rights,  privileges or options with respect to the
Collateral or Proceeds and shall not be responsible  for any failure to do so or
delay in so doing.

     8. PAYMENT OF  PREMIUMS,  TAXES,  CHARGES,  LIENS AND  ASSESSMENTS.  Debtor
agrees to pay, prior to delinquency,  all insurance  premiums,  taxes,  charges,
liens and assessments against the Collateral and Proceeds,  and upon the failure
of Debtor to do so, Bank at its option may pay any of them and shall be the sole
judge of the legality or validity  thereof and the amount necessary to discharge
the same. Any such payments made by Bank shall be obligations of Debtor to Bank,
due and  payable  immediately  upon  demand,  together  with  interest at a rate
determined in accordance with the provisions of Section 15 hereof,  and shall be
secured by the Collateral  and Proceeds,  subject to all terms and conditions of
this Agreement.

     9.  EVENTS  OF  DEFAULT.  The  occurrence  of any of  the  following  shall
constitute an "Event of Default"  under this  Agreement:  (a) any default in the
payment or performance of any obligation, or any defined event of default, under
(i) any  contract or  instrument  evidencing  any  Indebtedness,  (ii) any other
agreement  between any Debtor and Bank,  including  without  limitation any loan
agreement, relating to or executed in connection with any Indebtedness, or (iii)
any control,  custodial or other similar  agreement in effect among Bank, Debtor
and Intermediary relating to the Collateral;  (b) any representation or warranty
made by any Debtor  herein shall prove to be  incorrect,  false or misleading in
any material  respect when made; (c) any Debtor shall fail to observe or perform
any obligation or agreement contained herein; (d) any attachment or like levy on
any property of any Debtor; and (e) Bank, in good faith,  believes any or all of
the  Collateral  and/or  Proceeds  to  be  in  danger  of  misuse,  dissipation,
commingling,  loss,  theft,  damage or destruction,  or otherwise in jeopardy or
unsatisfactory in character or value.

     10. REMEDIES.  Upon the occurrence of any Event of Default, Bank shall have
the right to declare immediately due and payable all or any Indebtedness secured
hereby and to terminate any commitments to make loans or otherwise extend credit
to Debtor.  Bank shall have all other rights,  powers,  privileges  and remedies
granted to a secured party upon default under the California  Uniform Commerical
Code or otherwise  provided by law, including without  limitation,  the right to
contact all persons  obligated  to Debtor on any  Collateral  or Proceeds and to
instruct  such persons to deliver all  Collateral  and/or  Proceeds  directly to
Bank. All rights,  powers,  privileges and remedies of Bank shall be cumulative.
No delay,  failure or  discontinuance  of Bank in exercising  any right,  power,
privilege or remedy hereunder shall affect or operate as a waiver of such right,
power, privilege or remedy; nor shall any single or partial exercise of any such
right, power, privilege or remedy preclude,  waive or otherwise affect any other
or further exercise thereof or the exercise of any other right, power, privilege
or remedy.  Any waiver,  permit,  consent or approval of any kind by Bank of any
default  hereunder,  or any such waiver of any provisions or conditions  hereof,
must be in  writing  and  shall be  effective  only to the  extent  set forth in
writing.  It is agreed that public or private sales, for cash or on credit, to a
wholesaler or retailer or investor,  or user of property of the types subject to
this  Agreement,  or  public  auction,  are all  commercially  reasonable  since
differences  in the sales prices  generally  realized in the different  kinds of
sales are ordinarily  offset by the differences in the costs and credit risks of
such sales. While an Event of Default exists: (a) Debtor will not dispose of any
of the  Collateral or Proceeds  except on terms  approved by Bank;  (b) Bank may
appropriate  the  Collateral  and apply all  Proceeds  toward  repayment  of the
Indebtedness  in such order of  application as Bank may from time to time elect;
(c) Bank may take any action with respect to the Collateral  contemplated by any
control,  custodial or other similar agreement then in effect among Bank, Debtor
and  Intermediary;  and (d) at Bank's request,  Debtor will assemble and deliver
all books and  records  pertaining  to the  Collateral  or Proceeds to Bank at a
reasonably  convenient  place designated by Bank. For any Collateral or Proceeds
consisting of  securities,  Bank shall have no obligation to delay a sale of any
portion thereof for the period of time necessary to permit the issuer thereof to
register such  securities for public sale under any applicable  state or Federal
law, even if the issuer thereof would agree to do so.

     11. DISPOSITION OF COLLATERAL AND PROCEEDS. Upon the transfer of all or any
part of the Indebtedness, Bank may transfer all or any part of the Collateral or
Proceeds  and  shall be fully  discharged  thereafter  from  all  liability  and
responsibility  with  respect to any of the  foregoing so  transferred,  and the
transferee  shall be vested  with all rights and powers of Bank  hereunder  with
respect  to any  of the  foregoing  so  transferred;  but  with  respect  to any
Collateral or Proceeds not so transferred Bank shall retain all rights,  powers,
privileges and remedies herein given.  Any proceeds of any disposition of any of
the Collateral or Proceeds,  or any part thereof,  may be applied by Bank to the
payment of expenses incurred by Bank in connection with the foregoing, including
reasonable  attorneys'  fees, and the balance of such proceeds may be applied by
Bank toward the payment of the Indebtedness in such order of application as Bank
may from time to time elect.

     12. STATUTE OF LIMITATIONS.  Until all Indebtedness shall have been paid in
full  and  all  commitments  by  Bank to  extend  credit  to  Debtor  have  been
terminated,  the  power of sale and all other  rights,  powers,  privileges  and
remedies  granted to Bank hereunder shall continue to exist and may be exercised
by Bank at any time  and from  time to time  irrespective  of the fact  that the
Indebtedness  or any part  thereof  may have  become  barred by any  statute  of
limitations,  or that the personal  liability of Debtor may have ceased,  unless
such liability shall have ceased due to the payment in full of all  Indebtedness
secured hereunder.

     13. MISCELLANEOUS. (a) The obligations of Debtor are joint and several; (b)
Debtor  hereby waives any right (i) to require Bank to make any  presentment  or
demand, or give any notice of nonpayment or nonperformance,  protest,  notice of
protest  or notice of  dishonor  hereunder,  (ii) to direct the  application  of
payments or security for  Indebtedness of Debtor or indebtedness of customers of
Debtor, or (iii) to require  proceedings against others or to require exhaustion
of security;  and (c) Debtor  hereby  consents to  extensions,  forbearances  or
alterations  of the  terms of  Indebtedness,  the  release  or  substitution  of
security,  and the release of any  guarantors;  provided  however,  that in each
instance,   Bank  believes  in  good  faith  that  the  action  in  question  is
commercially  reasonable in that it does not  unreasonably  increase the risk of
nonpayment  of  the  Indebtedness  to  which  the  action  applies.   Until  all
Indebtedness  shall  have been paid in full, no Debtor  shall  have any right of
subrogation  or  contribution,  and each Debtor  hereby waives any benefit of or
right to  participate in any of the Collateral or Proceeds or any other security
now or hereafter held by Bank.

     14.  NOTICES.  All  notices,  requests  and  demands  required  under  this
Agreement must be in writing,  addressed to Bank at the address specified in any
other loan  documents  entered into between Debtor and Bank and to Debtor at the
address of its chief  executive  office (or personal  residence,  if applicable)
specified  below or to such other  address as any party may designate by written
notice to each  other  party,  and shall be deemed to have been given or made as
follows: (a) if personally delivered,  upon delivery;  (b) if sent by mail, upon
the  earlier of the date of receipt  or 3 days after  deposit in the U.S.  mail,
first class and postage prepaid; and (c) if sent by telecopy, upon receipt.

     15.  COSTS,  EXPENSES  AND  ATTORNEYS'  FEES.  Debtor  shall  pay  to  Bank
immediately  upon demand the full  amount of all  payments,  advances,  charges,
costs and expenses,  including  reasonable  attorneys'  fees (to include outside
counsel fees and all allocated  costs of Bank's in-house  counsel),  expended or
incurred by Bank in exercising any right,  power,  privilege or remedy conferred
by this Agreement or in the enforcement  thereof,  whether incurred at the trial
or appellate level, in an arbitration proceeding or otherwise, and including any
of  the  foregoing  incurred  in  connection  with  any  bankruptcy   proceeding
(including without  limitation,  any adversary  proceeding,  contested matter or
motion  brought by Bank or any other  person)  relating  to Debtor or in any way
affecting any of the  Collateral or Bank's ability to exercise any of its rights
or remedies with respect  thereto.  All of the foregoing shall be paid by Debtor
with  interest  from the date of demand  until  paid in full at a rate per annum
equal to the greater of ten percent  (10%) or the Prime Rate in effect from time
to time. The "Prime Rate" is a base rate that Bank from time to time establishes
and  which  serves as the basis  upon  which  effective  rates of  interest  are
calculated for those loans making reference thereto.

     16. SUCCESSORS;  ASSIGNS;  AMENDMENT.  This Agreement shall be binding upon
and  inure  to  the  benefit  of the  heirs,  executors,  administrators,  legal
representatives,  successors  and assigns of the parties,  and may be amended or
modified only in writing signed by Bank and Debtor.

     17.  OBLIGATIONS  OF MARRIED  PERSONS.  Any  married  person who signs this
Agreement as Debtor hereby expressly agrees that recourse may be had against his
or her separate  property for all his or her Indebtedness to Bank secured by the
Collateral and Proceeds under this Agreement.

     18. SEVERABILITY OF PROVISIONS. If any provision of this Agreement shall be
held to be prohibited by or invalid under  applicable  law, such provision shall
be ineffective  only to the extent of such  prohibition  or invalidity,  without
invalidating the remainder of such provision or any remaining provisions of this
Agreement.

     19.  GOVERNING  LAW. This  Agreement  shall be governed by and construed in
accordance with the laws of the state of Califomia

     20. ADDENDUM.  Additional  terms and conditions  relating to the Securities
Account are set forth in an Addendum attached hereto and incorporated  herein by
this reference.

     Debtor warrants that its chief executive office (or personal residence,  if
applicable) is located at the following address: 3347 INVESTMENT BLVD., HAYWARD,
CA 94545

     IN WITNESS  WHEREOF,  this  Agreement has been duly executed as of November
30, 1997.

CHOLESTECH CORPORATION

By: /s/ Warren Pinckert
   ---------------------
   WARREN PINCKERT
   PRESIDENT