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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D. C. 20549

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                                    FORM 8-K



                                 CURRENT REPORT



                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


                       Date of Report: September 21, 1998
                        (Date of earliest event reported)


                          INCYTE PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)


            Delaware                     0-27488              94-3136539
  (State or other jurisdiction         (Commission           (IRS Employer
        of incorporation)             File Number)         Identification No.)


                 3174 Porter Drive, Palo Alto, California, 94304
               (Address of principal executive offices) (Zip Code)


       Registrant's telephone number, including area code: (650) 855-0555


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Item 2.  Acquisition or Disposition of Assets.
         -------------------------------------

     On September 21, 1998 (the "Closing Date"), Incyte Pharmaceuticals, Inc.
("Incyte") acquired all of the issued and outstanding share capital of Hexagen
Limited, a company organized under the laws of England and Wales ("Hexagen"),
pursuant to the Share Purchase Agreement, dated as of September 21, 1998, among
Incyte, Hexagen and the shareholders of Hexagen (the "Share Purchase
Agreement"). As of the Closing Date, (i) Hexagen became a wholly owned
subsidiary of Incyte and (ii) Incyte exchanged an aggregate of 976,130 shares of
Common Stock, $.001 par value, of Incyte ("Incyte Common Stock") and $5,000,000
in cash for all of the shares of Hexagen capital stock outstanding immediately
prior to the Closing Date. The cash portion of the purchase price was provided
from Incyte's existing cash balances. Pursuant to the Share Purchase Agreement,
247,959 shares of Incyte Common Stock issued to former Hexagen shareholders have
been placed in escrow as security for any losses Incyte incurs or reasonably
anticipates incurring by reason of breaches by Hexagen of covenants,
representations or warranties contained in the Share Purchase Agreement.

     In addition, as of the Closing Date, each option to purchase Hexagen
ordinary shares ("Hexagen Shares") outstanding immediately prior to the Closing
and held by an employee of Hexagen was converted into an option to purchase
Incyte Common Stock and Incyte assumed each such outstanding Hexagen stock
option in accordance with the terms of Hexagen's 1996 Unapproved Share Option
Plan (the "Option Plan") and the stock option agreement by which it is
evidenced. The per-share exercise price for each such converted Hexagen stock
option is equal to $2.03 per share of Incyte Common Stock. Incyte also entered
into share exchange option agreements with each consultant to Hexagen holding
an option to purchase Hexagen Shares, pursuant to which, upon exercise of such
consultant's option to purchase Hexagen Shares, Incyte may exchange shares of
Incyte Common Stock for such Hexagen Shares based on the exchange ratio provided
for in the Share Purchase Agreement. An aggregate of 125,909 shares of Incyte
Common Stock are issuable at $2.03 per share upon the exercise in full of all
of the converted Hexagen options and pursuant to the consultant share exchange
agreements.

     Pursuant to the Share Purchase Agreement, Incyte has agreed to use its
reasonable efforts to file, and cause to become effective on or before March 20,
1999, a registration statement with the Securities and Exchange Commission
covering the resale of up to 40% of the shares of Incyte Common Stock issued to
each former shareholder of Hexagen pursuant to the Share Purchase Agreement.

     Hexagen has developed technology for rapid discovery of single nucleotide
polymorphisms, which are believed to be important in determining an individual
patient's susceptibility to disease or response to drugs. Hexagen will be a part
of Incyte's Incyte Genetics division.

     The foregoing description of the Share Purchase Agreement is qualified in
its entirety to the full text of such Share Purchase Agreement, a copy of which
is attached hereto as an exhibit and which is incorporated herein by reference.


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Item 7. Financial Statements and Exhibits.
        ----------------------------------

    (a)   Financial Statements of Business Acquired.

          It is impractical to provide the required financial statements at the
          time of the filing of this Current Report on Form 8-K.  Required 
          financial statements will be filed on a Form 8-K/A as soon as
          practicable after the date hereof, but not later than December 4,
          1998.

    (b)   Unaudited Pro Forma Financial Information.

          It is impractical to provide the required pro forma financial
          statements at the time of the filing of this Current Report
          on Form 8-K.  Required pro forma financial statements will be
          filed on Form 8-K/A as soon as practicable after the date hereof,
          but not later than December 4, 1998.

    (c)   Exhibits

    2.1   Share Purchase Agreement, dated as of September 21, 1998, by
          and among Incyte Pharmaceuticals, Inc., Hexagen Limited and
          the shareholders of Hexagen Limited.



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                                    SIGNATURE


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


     Dated: October 6, 1998.


                                   INCYTE PHARMACEUTICALS, INC.



                                   By       /s/ Denise M. Gilbert
                                      -----------------------------------------

                                   Name         Denise M. Gilbert
                                        ---------------------------------------

                                   Title    Executive Vice President, CFO
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                                INDEX TO EXHIBITS


 Exhibit 
 Number                         Description
 ------                         -----------

  2.1   Share Purchase Agreement, dated as of September 21, 1998, by and
        among Incyte Pharmaceuticals, Inc., Hexagen Limited and the
        shareholders of Hexagen Limited [ ]

        The following schedules and exhibits to the Share Purchase Agreement
        have been omitted. Incyte will furnish copies of the omitted 
        schedules and exhibits to the Commission upon request.

        Exhibit A - Form of Irrevocable Undertaking
        Exhibit D-1 - Form of Amendments to Hexagen plc Unapproved Share
        Option Plan 1996 (effective prior to Closing)
        Exhibit D-2 - Form of Amendments to Hexagen plc Unapproved Share
        Option Plan 1996 (effective upon Closing)
        Exhibit D-3 - Form of Option Exchange Agreement
        Exhibit D-4 - Form of Replacement Option Certificate
        Exhibit D-5 - Form of Option Release Deed
        Exhibit E - Form of Restrictive Covenants Agreement
        Schedule I  - Schedule of Consideration
        Schedule II - Schedule of Options to be Converted
        Schedule 2.2 - Post-Closing Directors and Officers of the Company;
        Resignations
        Schedule 7.3 - Schedule of Shareholders and Employees to be Parties to
        Restrictive Covenants Agreement and Employment Agreements



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