EXHIBIT 5 January 7, 2000 Laboratory Corporation of America Holdings 358 South Main Street Burlington, North Carolina 27215 Ladies and Gentlemen: I am an Executive Vice President, General Counsel and Secretary of Laboratory Corporation of America Holdings, and I offer this opinion in connection with the filing of a Registration Statement (the "Registration Statement") on Form S-8 under the Securities Act of 1933, as amended, relating to 3,200,000 shares of common stock, par value $0.01 per share (the "Common Stock"), deliverable in accordance with the Laboratory Corporation of America Holdings 1999 Stock Incentive Plan as referred to in such Form S-8 (the "Plan"). I have examined originals or copies, certified or otherwise identified to my satisfaction, of such documents, corporate records, certificates of public officials and other instruments relating to the adoption and amendment of the Plan as I have deemed necessary or advisable for the purposes of this opinion. Upon the basis of the foregoing, I am of the opinion that the Common Stock deliverable pursuant to the Plan, when delivered in accordance with the Plan will be duly authorized, validly issued, fully paid and nonassessable. I consent to the filing of this opinion as Exhibit 5 to the Registration Statement. Very truly yours, /s/ Bradford T. Smith, Esq. Executive Vice President, General Counsel and Secretary 16