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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
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                                SCHEDULE 14D-9/A
                                 (RULE 14d-101)

              SOLICITATION/RECOMMENDATION STATEMENT UNDER SECTION
                14(d)(4) OF THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 1)
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                          IMCLONE SYSTEMS INCORPORATED
                           (Name of Subject Company)
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                          IMCLONE SYSTEMS INCORPORATED
                       (Name of Person Filing Statement)

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                    Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                   45245W109
                     (CUSIP Number of Class of Securities)

                              John B. Landes, Esq.
                 Senior Vice President, Legal & General Counsel
                          ImClone Systems Incorporated
                               180 Varick Street
                               New York, NY 10014
                                  212-645-1405
  (Name, Address and Telephone Number of Person Authorized to Receive Notices
          and Communications on Behalf of the Person Filing Statement)

                                With a Copy to:
                             Phillip R. Mills, Esq.
                             Davis Polk & Wardwell
                              450 Lexington Avenue
                               New York, NY 10017
                                  212-450-4000

|_| Check the box if the filing relates solely to preliminary communications
made before the commencement of a tender offer.

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         This Amendment No. 1 amends and supplements the Schedule 14D-9 filed
with the Securities and Exchange Commission (the "SEC") on September 28, 2001
(the "Schedule 14D-9"), by ImClone Systems Incorporated (the "Company"),
relating to the tender offer by Bristol-Myers Squibb Biologics Company
("Purchaser"), a wholly owned subsidiary of Bristol-Myers Squibb Company
("Parent"), to purchase up to 14,392,003 shares of the Company's common stock,
par value $.001 per share (the "Shares"), for $70.00 per Share, net to the
seller in cash, upon the terms and subject to the conditions set forth in
Purchaser's Offer to Purchase, dated September 28, 2001, and in the related
Letter of Transmittal (which, together with any amendments or supplements
thereto, collectively constitute the "Offer"). The Offer is described in the
Tender Offer Statement on Schedule TO, dated September 28, 2001, which was
filed with the SEC on September 28, 2001 by Purchaser and Parent.

Item 8.  Additional Information.

         Item 8 of the Schedule 14D-9 is hereby amended and supplemented by
adding the following paragraph at the end of the subsection entitled
"Antitrust":

         The waiting period with respect to the Offer under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976 expired at 11:59 p.m. on
October 11, 2001.

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                                   SIGNATURE


      After due inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated: October 12, 2001


                                     IMCLONE SYSTEMS INCORPORATED


                                     By:    /s/ John B. Landes
                                       -------------------------------------
                                       Name:    John B. Landes
                                       Title:   Senior Vice President, Legal
                                                & General Counsel



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