EXHIBIT 8.1
Principal Subsidiaries, Joint Ventures and Associates
Percentage of voting
At 31 December 2002 Country share capital held Principal activity
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UK
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AstraZeneca UK Limited England 100# Research, production, marketing
AstraZeneca Insurance Company Limited England 100 Insurance and reinsurance underwriting
AstraZeneca Treasury Limited England 100 Treasury
Continental Europe
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NV AstraZeneca SA Belgium 100 Marketing
ASP SA France 100 Production
AstraZeneca Pharma SA France 100 Research, production, marketing
AstraZeneca GmbH Germany 100 Development, production, marketing
AstraZeneca Holding GmbH Germany 100 Production, marketing
AstraZeneca SpA Italy 100 Production, marketing
AstraZeneca Farmaceutica Spain SA Spain 100 Production, marketing
AstraZeneca AB Sweden 100 Research and development, production,
marketing
Astra Tech AB Sweden 100 Research and development,
production, marketing
AstraZeneca BV The Netherlands 100 Marketing
The Americas
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AstraZeneca do Brasil Ltda. Brazil 100 Production, marketing
AstraZeneca Canada Inc. Canada 100 Research, production, marketing
IPR Pharmaceuticals Inc. Puerto Rico 100 Development, production, marketing
AstraZeneca LP US 99 Development, production, marketing
AstraZeneca Pharmaceuticals LP US 100 Development, production, marketing
Salick Health Care, Inc. US 100 Provision of disease-specific
healthcare services
Zeneca Holdings Inc. US 100 Production, marketing
Asia, Africa & Australasia
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AstraZeneca Pty Limited Australia 100 Research, production, marketing
AstraZeneca Pharmaceutical Co., Limited China 100 Production, marketing
AstraZeneca Hong Kong Limited Hong Kong 100 Production
AstraZeneca KK Japan 80 Production, marketing
# shares held directly
The companies and other entities listed above are those whose results or
financial position principally affected the figures shown in the Group's annual
financial statements. A full list of subsidiaries, joint ventures and
associates will be annexed to the Company's next annual return filed with the
Registrar of Companies. The country of registration or incorporation is stated
alongside each company. The accounting dates of principal subsidiaries and
associates are 31 December, except for Salick Health Care, Inc. which is 30
November. AstraZeneca operates through 235 subsidiary companies worldwide.
Products are manufactured in some 20 countries worldwide and are sold in over
100 countries.