Exhibit 23 Independent Auditors' Consent The Board of Directors OraSure Technologies, Inc.: We consent to the incorporation by reference in the registration statements (No. 333-102235, No. 333-50340 and No. 333-48662) on Form S-8 and the registration statement (No. 333-73498) on Form S-3 of OraSure Technologies, Inc. of our report dated January 27, 2003, with respect to the balance sheet of OraSure Technologies, Inc. as of December 31, 2002, and the related statements of operations, stockholders' equity and comprehensive loss, and cash flows for the year then ended, which report appears in the December 31, 2002 annual report on Form 10-K of OraSure Technologies, Inc. /s/ KPMG LLP Philadelphia, Pennsylvania March 31, 2003