EXHIBIT 22.1 LIST OF SUBSIDIARIES OF ROTECH MEDICAL CORPORATION A-1 Medical Equipment, Inc., a Florida corporation American Medical Rentals, Inc., a Arkansas corporation Beta Medical Equipment, Inc., a Florida corporation Biocare Medical, Inc., a Florida corporation Bravo Home Health Care, Inc., a Florida corporation Breathing and Relief, Inc., a Florida corporation Brister's Medical Associates, Inc., a Mississippi corporation Brister Pharmacy, Inc., a Mississippi corporation Brooksville Primary Care Clinic, Inc., a Florida corporation Camden Medical Supply, Inc., a Florida corporation Care Medical Supplies, Inc., a Illinois corporation Charlotte Medical Supply, Inc., a Florida corporation Church Street Clinic, Inc., a Mississippi corporation Clinical Laboratory, Inc., a Mississippi corporation Community Home Oxygen, Inc., a Montana corporation Cynthiana Home Health Care, Inc., a Florida corporation Distinct Home Health Care, Inc., a Florida corporation Drew Primary Care Clinic, Inc., a Mississippi corporation East Tennessee Infusion & Respiratory, Inc., a Florida corporation Encore Home Health Care, Inc., a Florida corporation Epsilon Home Health Care, Inc., a Florida corporation Essential Home Health Care, Inc., a Florida corporation Eta Home Health Care, Inc., a Florida corporation LIST OF SUBSIDIARIES OF ROTECH MEDICAL CORPORATION (CONT.) Family Care Specialists, Inc., a Florida corporation Gate City Medical Equipment, Inc., a Florida corporation Greenville Primary Care Clinic, Inc., a Mississippi corporation Greenwood Multi-Specialty Clinic, Inc., a Mississippi corporation Grenada Doctors Clinic, Inc., a Mississippi corporation Grenada Family Doctors, Inc., a Mississippi corporation Headache Center of the West Coast, Inc., a Florida corporation Headache Management of America, Inc., a Florida corporation Headache and Pain Management Center, Inc., a Florida corporation Health & Medications at Home, Inc., a North Carolina corporation Health at Home, Inc., a Florida corporation Healthcare Business Solutions, Inc., a Florida corporation Healthcare Claims Recovery, Inc., a Florida corporation Health Care Services of Mississippi, Inc., a Florida corporation Heartland Home Care, Inc., a Florida corporation Holland Medical Services, Inc., a Florida corporation Hollandale Primary Care, Inc., a Florida corporation Home Care Solutions of Murray, Inc., a Florida corporation Home Medical Systems, Inc., a South Carolina corporation Indianola Primary Care Clinic, Inc., a Mississippi corporation Integral Home Health Care, Inc., a Florida corporation Intensive Home Care Nurses, Inc., a Texas corporation Intensive Home Care Services, Inc., a Texas corporation Internal Medicine Grand View, Inc., a South Carolina corporation International Medical Services and Supplies, Inc., a Florida corporation International Therapeutic Services, Inc., a Florida corporation LAMS, Inc., a Texas corporation Lexington Primary Care, Inc., a Mississippi corporation Liberty Home Health Care, Inc., a Florida corporation Lovejoy Medical, Inc., a Kentucky corporation MHB, Inc., a West Virginia corporation Macon Primary Care Clinic, Inc., a Florida corporation Major Medical Supply, Inc., a Texas corporation Medic-Aire Medical Equipment, Inc., a Florida corporation Medical Electro-Therapeutics, Inc., a Florida corporation National Medical Equipment Centers, Inc., a Florida corporation National Medicine Center - Groveland, Inc., a Florida corporation Nightingale Home Health Care, Inc., a Texas corporation North Florida Pain Institute, Inc., a Florida corporation Oxygen Therapy Associates, Inc., a Texas corporation PSI Health Care, Inc., a South Dakota corporation Perry Family Practice, Inc., a Florida corporation Physician's Formulary Services, Inc., a Florida corporation Pioneer Medical Services, Inc., a West Virginia corporation Polk City Pharmacy, Inc., a Florida corporation Primary Home Health Care, Inc., a Florida corporation LIST OF SUBSIDIARIES OF ROTECH MEDICAL CORPORATION (CONT.) Pulmo-Dose, Inc., a Florida corporation Quality Home Health Care, Inc., a Florida corporation RCG Information Services Corporation, a Florida corporation RN Home Care Medical Equipment Company, Inc., a Mississippi corporation Respitech Home Health Care, Inc., a Wyoming corporation Responsive Home Health Care, Inc., a Florida corporation RoTech Employee Benefits Corporation, a Florida corporation RoTech Home Medical Care, Inc., a Florida corporation RoTech Oxygen & Medical Equipment, Inc., a Florida corporation RoTech/Texas, Inc., a Florida corporation Rothert's Hospital Equipment, Inc., a Kentucky corporation Select Home Health Care, Inc., a Florida corporation Senatobia Family Practice, Inc., a Mississippi corporation South County Health Care Services, a Texas corporation South County Private Duty Agency, Inc., a Texas corporation Southern IV Therapy, Inc., a Florida corporation Southern Medical, Inc., a Florida corporation Stat Medical Equipment, Inc., a Florida corporation Sunshine Home Health Care, Inc., a Florida corporation The Towne Pharmacy, Inc., a West Virginia corporation Theta Home Health Care, Inc., a Florida corporation Tupelo Home Health, Inc., a Florida corporation Valley Medical, Inc., a Utah corporation Value Care, Inc., a Florida corporation VitalCare Health Services, Inc., a Florida corporation VitalCare of America, Inc., a Texas corporation VitalCare of Florida, Inc., a Florida corporation VitalCare of Nevada, Inc., a Nevada corporation VitalCare of Pennsylvania, Inc., a Pennsylvania corporation VitalCare of Texas, Inc., a Texas corporation Vitech Medical, Inc., a Florida corporation Western North Carolina Home Health Care, Inc., a Florida corporation Wichita Medical Care, Inc., a Kansas corporation Women's Health Care Services, Inc., a Florida corporation Zeta Home Health Care, Inc., a Florida corporation