As filed with the Securities and Exchange Commission on May 28, 1996
Registration No. 333-3978
 
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                            ______________________
                                  FORM S-1MEF
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933
                            ______________________
                       AMISYS MANAGED CARE SYSTEMS, INC.
             (Exact name of registrant as specified in its charter)

          Delaware          7373                          13-3355918
  (State or other           (Primary standard             (I.R.S. employer
  jurisdiction of           industrial                    identification number)
  incorporation or          classification code number)
  organization)           
                                                                                
                         30 West Gude Drive, 5th Floor
                           Rockville, Maryland  20850
                                 (301) 251-8600
              (Address, including zip code, and telephone number,
                 including area code, of registrant's principal
                               executive offices)

                                 Kevin R. Brown
                       President, Chief Executive Officer
                       AMISYS MANAGED CARE SYSTEMS, INC.
                         30 West Gude Drive, 5th Floor
                           Rockville, Maryland  20850
                                 (301) 251-8600
               (Name, address, including zip code, and telephone
               number, including area code, of agent for service)
                           ________________________

               Michael J. Silver               Robert B. Ott
               Hogan & Hartson L.L.P.         Arnold & Porter
               111 S. Calvert Street, Suite 1600  555 Twelfth Street, N.W.
               Baltimore, MD  21202        Washington, DC  20004-1202
               (410) 659-2700                 (202) 942-5008
                           ________________________
          Approximate date of commencement of proposed sale to the public:  As
soon as practicable after the effective date of this Registration Statement.

          If any of the securities being registered on this Form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933, check the following box.  /q/

          If this Form is filed to register additional securities for an
offering pursuant to Rule 462(b) under the Securities Act, please check the
following box and list the Securities Act registration statement number of the
earlier effective registration statement for the same offering.  /y/  333-3978

          If this Form is a post-effective amendment filed pursuant to Rule
462(c) under the Securities Act, check the following box and list the Securities
Act registration statement number of the earlier effective registration
statement for the same offering.  /q/

               If delivery of the prospectus is expected to be made pursuant to
Rule 434, please check the following box.  /q/
                           ________________________
                        CALCULATION OF REGISTRATION FEE





 
                                           Proposed    Proposed      Amount of
    Title of each class       Amount to    maximum      maximum    registration
    of securities to be          be        offering    aggregate        fee
      registered             registered     price      offering
                                           per unit    price (1)
                                             (1)
                                                        
 
Common Stock, $.001 par           10,000     $26.00     $260,000         $100.00
 value
================================================================================


(1) Estimated solely for purposes of calculating the registration fee pursuant
    to Rule 457(c).
                           ________________________
                                        

 
Explanatory Note

  This registration statement is being filed pursuant to Rule 462(b) under the
Securities Act of 1933, as amended, to register an additional 10,000 shares of
Common Stock of AMISYS Managed Care Systems, Inc. (the "Company") to be sold by
Kevin R. Brown, Chairman, President and Chief Executive Officer of the Company.
This registration statement includes the facing page, the signature page, an
exhibit index, an accountants' consent and an exhibit 5 legal opinion. Kevin R.
Brown beneficially owned 324,000 shares (4.28%) of common stock prior to the
offering and will beneficially own 264,000 shares (3.48%) following the
offering. Following the offering, all directors and officers as a group will
beneficially own 3,843,360 shares (49.91%) of common stock. Pursuant to Rule
462(b) and General Instruction V to Form S-1, the contents of Registration
Statement No. 333-3978 (declared effective at 4:00 p.m. on May 28, 1996) are
incorporated by reference herein.


 
Item 16.  Exhibits and Financial Statement Schedules.

   (a)   Exhibits:

Exhibit
Number           Description
- -------          -----------

   5.01    Opinion of Hogan & Hartson L.L.P. as to the legality of the Common
           Stock being registered.
   23.01   Consent of Hogan & Hartson L.L.P. (contained in Exhibit 5.01).
   23.02   Consent of Coopers & Lybrand L.L.P.
   24.01*  Power of Attorney (contained in signature page).
   27.01   Financial Data Schedule.
- -----------------------------------
*Incorporated by reference to the Registration's Registration Statement on Form
S-1 (333-3978).

 
                        SIGNATURES AND POWER OF ATTORNEY


         Pursuant to the requirements of the Securities Act of 1933, the
Registrant has duly caused this Registration Statement to be signed on its
behalf by the undersigned, thereunto duly authorized, in the City of Rockville,
State of Maryland, on May 28, 1996.

                     AMISYS MANAGED CARE SYSTEMS, INC.



                     By: /s/ Robert J. Sullivan
                        ---------------------------
                         Robert J. Sullivan
                         Vice President, Chief Financial Officer (Principal 
                           Financial Officer and Principal Accounting
                           Officer).

          Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed by the following persons in the
capacities and on the date indicated.
 
 
 
                              Chief Executive Officer, President
/s/  *                        and Director (Principal Executive     May 28, 1996
- ---------------------------   Officer)
Kevin R. Brown
 
                             Vice President, Chief Financial
                             Officer (Principal Financial Officer
/s/  Robert J. Sullivan      and Principal Accounting Officer)      May 28, 1996
- ---------------------------
Robert J. Sullivan
 
 
 
/s/  *                       Director                               May 28, 1996
- ---------------------------
Peter J. Barris
 
 
/s/  *                       Director                               May 28, 1996
- ---------------------------
Howard E. Cox, Jr.
 

 
/s/  *                       Director                               May 28, 1996
- ---------------------------
Donald B. Hebb, Jr.
 
 
/s/  *                       Director                               May 28, 1996
- ---------------------------
Arthur J. Marks
 
 
/s/  *                       Director                               May 28, 1996
- ---------------------------
Gary Greenfield
 
 
By:  Robert J. Sullivan                                             May 28, 1996
     ------------------
          Robert J. Sullivan
          Attorney-in-fact