EXHIBIT 10.4 ------------ MYRIAD GENETICS, INC. HAS OMITTED FROM THIS EXHIBIT 10.4 PORTIONS OF THE AGREEMENT FOR WHICH MYRIAD GENETICS, INC. HAS REQUESTED CONFIDENTIAL TREATMENT FROM THE SECURITIES AND EXCHANGE COMMISSION. THE PORTIONS OF THE AGREEMENT FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED ARE MARKED "[ ]" AND SUCH CONFIDENTIAL PORTIONS HAVE BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. March 4, 1996 Dr. Lisa Cannon-Albright Genetic Epidemiology University of Utah 391 Chipeta Way #D-2 Salt Lake City, Utah 84108 RE: Sub-contract titled: Isolation and Characterization of Genes Predisposing to Cancer. University Acct. No. 5-20639 Dear Dr. Cannon-Albright: This modification is made and entered into by and between the University of Utah and Myriad Genetics, Inc. As the original agreement states, any extension must be mutually agreed upon in writing between the parties. The purpose of this modification is to approve an additional year of funding in the amount of [ ] ([ ] and [ ] costs of [ ]) (see attached budget) from March 1, 1996 to February 28, 1997. The Principal Investigator will be Lisa Cannon-Albright for this new year funding. Approval Signatures: Myriad Genetics, Inc. /s/ Peter Meldrum ------------------------------ Peter Meldrum-President Genetic Epidemiology /s/ Dr. Lisa Cannon-Albright ------------------------------ Dr. Lisa Cannon-Albright University of Utah /s/ Robert G. Glass ------------------------------- Acting for Nancy V. Dyke,Associate Director Office of Sponsored Projects -2- BUDGET FOR 1996 - 1997 Salaries and Wages $ [ ] Fringe Benefits $ [ ] Total Personnel $ [ ] Supplies $ [ ] Total Direct Costs $ [ ] Indirect Costs ([ ]MTDC) $ [ ] Total $ [ ] -3-