EXHIBIT 10.4
                                                            ------------



MYRIAD GENETICS, INC. HAS OMITTED FROM THIS EXHIBIT 10.4 PORTIONS OF THE
AGREEMENT FOR WHICH MYRIAD GENETICS, INC. HAS REQUESTED CONFIDENTIAL TREATMENT
FROM THE SECURITIES AND EXCHANGE COMMISSION.  THE PORTIONS OF THE AGREEMENT FOR
WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED ARE MARKED "[    ]" AND SUCH
CONFIDENTIAL PORTIONS HAVE BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION.


March 4, 1996

Dr. Lisa Cannon-Albright
Genetic Epidemiology
University of Utah
391 Chipeta Way #D-2
Salt Lake City, Utah 84108

RE:  Sub-contract titled: Isolation and Characterization of Genes Predisposing
     to Cancer. University Acct. No. 5-20639

Dear Dr. Cannon-Albright:

This modification is made and entered into by and between the University of Utah
and Myriad Genetics, Inc.  As the original agreement states, any extension must
be mutually agreed upon in writing between the parties.

The purpose of this modification is to approve an additional year of funding in
the amount of [       ] ([            ] and [         ] costs of [          ])
(see attached budget) from March 1, 1996 to February 28, 1997.

 
The Principal Investigator will be Lisa Cannon-Albright for this new year
funding.

Approval Signatures:            Myriad Genetics, Inc.

  
                                           /s/ Peter Meldrum
                                           ------------------------------
                                           Peter Meldrum-President


                                           Genetic Epidemiology


                                           /s/ Dr. Lisa Cannon-Albright
                                           ------------------------------
                                           Dr. Lisa Cannon-Albright


                                           University of Utah


                                           /s/ Robert G. Glass
                                           -------------------------------
                                           Acting for
                                           Nancy V. Dyke,Associate Director
                                           Office of Sponsored Projects

                                      -2-

 
BUDGET FOR 1996 - 1997


 
                                    
Salaries and Wages                       $  [     ]
 
Fringe Benefits                          $  [     ]
                       
 
     Total Personnel                     $  [     ]
 

Supplies                                 $  [     ]
                                              


Total Direct Costs                       $  [     ]

Indirect Costs
([    ]MTDC)                             $  [     ]
                                             


Total                                    $  [     ]



                                      -3-