SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


       Date of report (Date of earliest event reported): June 1, 1998


                            NEOSE TECHNOLOGIES, INC.
                 -----------------------------------------------
                 (Exact Name of Registrant Specified in Charter)


        Delaware                   0-27718                 13-3549286
    ---------------              ------------          -------------------
    (State or Other              (Commission            (I.R.S. Employer
    Jurisdiction of              File Number)          Identification No.)
     Incorporation)


           102 Witmer Road, Horsham, Pennsylvania            19044
          ----------------------------------------        ----------
          (Address of Principal Executive Offices)        (Zip Code)


       Registrant's telephone number, including area code: (215) 441-5890


          -------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)





Item 5. Other Events

     On June 1, 1998, Neose Technologies, Inc. (the "Company") entered into a
Research and Development Agreement with the Pharmaceutical Research Institute of
Bristol-Meyers Squibb Company, a Delaware corporation ("BMS"), to develop
proprietary processes for the manufacture of complex carbohydrates for two
cancer vaccines being developed by BMS (the "R&D Agreement"). The R&D Agreement
provides for the Company to receive payments upon the completion of certain
milestones. BMS may terminate the R&D Agreement upon ninety days prior
written notice. If BMS decides to purchase any complex carbohydrates from the
Company after commercializing either of its vaccines, the Company and BMS will
need to negotiate the terms of a manufacturing supply agreement.

     On October 12, 1999, the Company entered into an Operating Agreement with
McNeil PPC, Inc., acting through its division McNeil Specialty Products Company
("McNeil"), for the purpose of forming Magnolia Nutritionals LLC, a limited
liability company organized under the laws of the State of Delaware, to develop
the cost-effective production of certain complex carbohydrates (the "Operating
Agreement"). The joint venture replaces and expands the previous research and
development agreement between the Company and McNeil.

     On November 3, 1999, the Company entered into a Collaboration and License
Agreement (the "Collaboration Agreement") with American Home Products
Corporation, acting through its subsidiary company, Wyeth-Ayerst International
Inc. ("Wyeth"), to develop and commercialize a bioactive milk-based carbohydrate
for use in infant and pediatric nutritional formulas marketed by Wyeth. Under
the Collaboration Agreement, the two companies will conduct a joint research and
development program, with Wyeth's activities focused on use of the ingredient in
its pediatric products, and with the Company's activities focused on the
development of commercial scale manufacturing capabilities for the novel
bioactive carbohydrate ingredient. The Collaboration Agreement provides for
development fees payable to the Company prior to commercialization, and
anticipates that the Company will manufacture and sell novel ingredients to
Wyeth, and will receive royalties upon commercialization.






     The R&D Agreement, the Operating Agreement and the Collaboration Agreement
are filed as Exhibits 99.1, 99.2 and 99.3, respectively, to this Current Report
on Form 8-K. This summary description of the transaction is qualified in its
entirety by reference to the documents filed as exhibits hereto.


Item 7. Financial Statements, Pro Forma Financial Information and Exhibits

        (c) Exhibits

        Exhibit Number        Description
        --------------        -----------

             99.1*            Research and Development Agreement, dated June 1,
                              1998, between Neose Technologies, Inc. and the
                              Pharmaceutical Research Institute of Bristol-Myers
                              Squibb Company.

             99.2*            Operating Agreement of Magnolia Nutritionals LLC,
                              dated October 12, 1999, between Neose
                              Technologies, Inc. and McNeil PPC, Inc., acting
                              through its division McNeil Specialty Products
                              Company.

             99.3*            Collaboration and License Agreement, dated
                              November 3, 1999, between Neose Technologies, Inc.
                              and American Home Products Corporation.


Explanation of Footnotes to List of Exhibits

* The Company has intentionally omitted portions of the exhibits from this
filing. The Company has submitted an application for confidential treatment,
which includes the omitted portions, to the Securities and Exchange Commission.
The application for confidential treatment was filed as specified in Rule 24b-2
of the Securities Exchange Act of 1934.


                                    SIGNATURE

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                      NEOSE TECHNOLOGIES, INC.


                                      By: /s/ P. Sherrill Neff
                                          -------------------------------------

                                          P. Sherrill Neff
                                          President and Chief Financial Officer

Dated: February 2, 2000





                                  Exhibit Index

Exhibit Number        Description
- --------------        -----------

    99.1*             Research and Development Agreement, dated June 1, 1998,
                      between Neose Technologies, Inc. and the Pharmaceutical
                      Research Institute of Bristol-Myers Squibb Company.

    99.2*             Operating Agreement of Magnolia Nutritionals LLC, dated
                      October 12, 1999, between Neose Technologies, Inc. and
                      McNeil PPC, Inc., acting through its division McNeil
                      Specialty Products Company.

    99.3*             Collaboration and License Agreement, dated November 3,
                      1999, between Neose Technologies, Inc. and American Home
                      Products Corporation.

*    The Company has intentionally omitted portions of the exhibits from this
     filing. The Company has submitted an application for confidential
     treatment, which includes the omitted portions, to the Securities and
     Exchange Commission. The application for confidential treatment was filed
     as specified in Rule 24b-2 of the Securities Exchange Act of 1934.