Exhibit 16.1
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July 31, 1997

Securities and Exchange Commission 
450 5th Street, N.W.
Washington, D.C. 20549

Gentlemen,

We have read the statements made by IGI, Inc., (copy attached), which we
understand will be filed with the Commission, pursuant to Item 4 of Form 8-K, as
part of the Company's Form 8-K report for the month of July 1997. We agree with
the statements concerning our Firm in such Form 8-K.

Very truly yours,

Coopers & Lybrand L.L.P.