October 28, 2005 Mr. John Cash Accounting Branch Chief Securities and Exchange Commission Division of Corporation Finance Washington, DC 20549 Re: Strategic Diagnostics Inc. Form 10-K for the year ended December 31, 2004 Filed March 30, 2005 File No. 000-22400 Dear Mr. Cash: This letter is in response to comments of the Staff contained in your letter to Anthony J. Simonetta, Vice President -- Finance and Chief Financial Officer of Strategic Diagnostics Inc. ("management", "we", "our", "us" or the "Company"), dated October 12, 2005. The comments in the Staff's letter have been set forth below, along with the Company's responses thereto. The information contained herein is being furnished by the Company on a supplemental basis. FORM 10-K FOR THE PERIOD ENDED DECEMBER 31, 2004 - ------------------------------------------------ o A DESCRIPTION OF THE NATURE OF THE COSTS INCURRED TO PRODUCE YOUR FARM ANIMALS. The costs incurred to produce our farm animals include the following: o Salaries and benefits for the individuals, who feed the animals, clean the cages and generally care for the animals. o Professional fees for the periodic visits to the farm by a Veterinarian to assess the health of the animals. Mr. John Cash October 28, 2005 Page Two o Animal feed, water and bedding materials. o Operating expenses (such as depreciation, utilities, maintenance & repairs) related to the housing of the animals. o HOW YOU ACCOUNT FOR THE COSTS TO MAINTAIN YOUR FARM SUCH AS THE DEPRECIATION ON ANY BUILDINGS, LABOR, MAINTENANCE, THE COST OF ANIMAL FEED, ETC. The costs associated with maintaining the farm, including such things as depreciation on buildings, labor, repairs and maintenance and animal feed are directly charged as incurred as a component of Cost of Goods Sold (COGS). o HOW THE AMOUNT TO BE CAPITALIZED FOR YOUR FARM ANIMALS IS DETERMINED. For animals we breed, the Company assigns a rate by animal type that is estimated to approximate the cost of breeding the animal. These breeding costs include: the purchase price of the breeding parents, animal feed, animal bedding, animal husbandry, animal disposal and pro rata building costs. The rate is updated annually at the end of the calendar year. For animals we purchase, the rate is the cost of acquisition. To determine the amount to be capitalized each period, a census is taken at the end of a period and the cost of all animals waiting to be assigned to projects is accumulated at the applicable rates. The change in total animal costs from the prior period to the current period is then charged or credited to COGS. o WHAT PERCENTAGE OF COSTS THE ANIMALS REPRESENT OF YOUR TOTAL COSTS FOR A GIVEN CUSTOMIZED ANTIBODY ARRANGEMENT. The percentages of costs animals represent for a typical customized antibody arrangement are approximately: o Rabbit 20% o Mouse 55% o Goat 26% o Rat 17% o Guinea Pig 40% o Chicken 10% o THE AVERAGE COST ASSIGNED TO THE ANIMALS THAT YOU PRODUCE, BY SPECIFIC ANIMAL TYPE (E.G. RATS, RABBITS). Mr. John Cash October 28, 2005 Page Three The average costs assigned to the animals we breed as of December 31, 2004 (the last time updated) are as follows: o Rabbits - $16.24 o Mice - $ 6.81 All other species are purchased from outside vendors. o THE PERCENTAGE OF ANIMALS THAT ARE PRODUCED BY YOU VERSUS THOSE THAT ARE PURCHASED FROM THIRD PARTIES. Approximately 99% of the rabbits and 85% of the mice used in projects are bred by us. Substantially all of our custom antibody projects use either rabbits or mice. As noted above, all other species of animals are purchased from outside vendors. o THE AVERAGE PER ANIMAL PURCHASE PRICE FOR EACH PERIOD PRESENTED, BY SPECIFIC ANIMAL TYPE. 2ND QTR 2005 2004 2003 2002 ------------ ---- ---- ---- o Goats - $200.00 $200.00 $200.00 $200.00 o Sheep - $200.00 $200.00 $200.00 $200.00 o Mice - $ 10.84 $ 9.90 $ 9.00 $ 8.33 o Guinea Pig - $ 72.15 $ 64.50 $ 50.50 $ 48.60 o Rats - $ 24.20 $ 24.20 $ 22.70 N/A o Rabbits - $ 93.00 $ 90.00 N/A $ 65.00 o Chickens - $10.01 $ 10.01 N/A N/A N/A means no such animals were purchased in the applicable year. o WHY YOU BELIEVE IT IS APPROPRIATE TO INCLUDE THE CAPITALIZED AMOUNTS IN YOUR "OTHER CURRENT ASSETS" ACCOUNT, INSTEAD OF YOUR INVENTORY ACCOUNT. All animals used in our antibody projects, whether bred by us or not, are not the end product they are a tool that enables us to produce the product. We do not breed animals for sale. The animals in question have not yet been assigned to a project and, therefore, we believe represent an "other current asset" to the Company. In addition, the cost of the animals capitalized at any given period end is relatively small in relation to our total inventory (e.g. at June 30, 2005, $61,000 in capitalized animal costs compared to $3.1 million in inventory). Based upon all of the above, Mr. John Cash October 28, 2005 Page Four management concluded that it is appropriate to include the cost of animals not yet assigned to projects as an "other current asset". o DESCRIBE HOW YOUR FARM COSTS ARE RECOGNIZED FOR FINANCIAL REPORTING PURPOSES AS MANUFACTURING COSTS AND ALSO APPLIED TO INDIVIDUAL CONTRACTS. EXPLAIN HOW SUCH COSTS ARE ACCUMULATED IN AND SUBTRACTED FROM OTHER CURRENT ASSETS. A BRIEF EXAMPLE INCLUDING A SERIES OF JOURNAL ENTRIES MAY BE HELPFUL IN THIS REGARD. o Farm costs are recognized for financial reporting purposes as manufacturing costs as incurred. The farm costs assigned to individual contracts are represented by the cost of animals we breed and subsequently assign to a project. o As noted above, a census is taken at the end of each period and the cost of all animals waiting to be assigned to projects is accumulated at the applicable rates. The change from the prior period to the current period is then charged or credited to COGS. o Attached is the June 30, 2005 journal entry for capitalized animal costs with supporting census. Any comments or questions with respect to the foregoing should be addressed to Anthony J. Simonetta of the Company at 302-456-6789 ext. 305. Very truly yours, /s/ Anthony J. Simonetta Anthony J. Simonetta, Vice President - Finance and CFO cc: Ellen Goitia, KPMG Justin Chairman, Morgan Lewis Patricia Armelin, SEC Jeanne Baker, SEC STRATEGIC DIAGNOSTICS INC. ANIMAL CENSUS - JUNE 2005 JUNE 2005 MAY 2005 MAINE # of Animals Cost Value # of Animals Cost Value Goats - Maine 49 $200.00 $9,800.00 35 $200.00 $7,000.00 Sheep - Maine 0 $200.00 $0.00 0 $200.00 $0.00 Rabbits - Maine 861 $16.24 $13,982.64 830 $16.24 $13,479.20 Chickens - Maine 82 $10.01 $820.82 42 $10.01 $420.42 Mice - Maine 71 $6.81 $483.51 195 $6.81 $1,327.95 Guinea Pigs - Maine 13 $72.15 $937.95 4 $72.15 $288.60 Rats 0 $24.20 $0.00 32 $24.20 $774.40 Subtotal Maine 1,076 $26,024.92 1,138 $23,290.57 DELAWARE Mice - unassigned 4,043 $6.81 $27,532.83 1,874 $6.81 $12,761.94 Mice - Breeding 1,059 $6.81 $7,211.79 1,730 $6.81 $11,781.30 Subtotal Delaware 5,102 $34,744.62 3,604 $24,543.24 Total Prepaid Animals 6,178 $60,769.54 4,742 $47,833.81 - -------------------------------------------------------------------------------------------------------------------------- JOURNAL ENTRY: (DR) (CR) ANIMAL COSTS - MAINE $2,734.35 ANIMAL COSTS - DELAWARE $10,201.38 PREPAID ANIMAL EXPENSE $13,129.33 - -------------------------------------------------------------------------------------------------------------------------- STRATEGIC DIAGNOSTICS INC. Animal Census - June 30, 2005 JAN FEB MAR APR MAY JUN - ------------------------------- GOATS - ------------------------------- CUSTOM-CA 9 9 8 8 8 8 SBS-ME 95 94 88 90 89 89 CUSTOM-ME 245 248 251 284 278 277 RESERVED 6 2 4 3 6 39 PRESCREENS 0 0 1 0 0 17 FUTURE NEW STARTS 2 0 3 0 0 0 NON-IMMUN-ME 43 39 34 6 35 49 TOTAL 400 392 389 391 416 479 - ------------------------------- SHEEP - ------------------------------- SBS-ME 0 0 0 0 0 0 CUSTOM-ME 14 17 16 13 13 13 RESERVED 3 0 0 0 0 0 PRESCREENS 0 0 0 0 0 0 FUTURE NEW STARTS 0 0 0 0 0 0 NON-IMMUN-ME 1 1 1 1 0 0 TOTAL 18 18 17 14 13 13 - ------------------------------- RABBITS - ------------------------------- CUSTOM-CA 6 5 5 5 5 5 SBS-ME 13 4 4 4 4 4 CUSTOM-ME 5,213 5,276 5,372 5,474 5,567 5,511 RESERVED 13 12 6 8 27 13 PRESCREENS 126 141 125 112 95 127 FUTURE NEW STARTS 63 110 59 78 72 34 NON-IMMUN-ME 490 334 285 229 326 350 BREEDERS-ME 556 546 530 529 504 511 GROWING KITS 2,830 2,830 2,830 2,830 2,830 2,830 SPEC FEED-ME 31 26 14 4 0 29 TOTAL 9,341 9,284 9,230 9,273 9,430 9,414 - ------------------------------- CHICKENS - ------------------------------- SBS-ME 0 0 0 0 0 0 CUSTOM-ME 183 185 160 159 44 58 RESERVED 0 2 0 0 10 0 PRESCREENS 0 0 0 0 0 0 FUTURE NEW STARTS 3 0 0 2 2 2 NON-IMMUN-ME 28 17 67 57 42 82 TOTAL 214 204 227 218 98 142 - ------------------------------- MICE - ------------------------------- HYBRIDOMA-ME 0 0 0 0 0 0 MONOCLONAL-ME 0 0 0 0 0 0 CUSTOM-ME 39 22 14 23 25 16 GI 165 439 432 166 RESERVED 0 2 276 0 0 0 PRESCREENS 0 0 0 0 0 0 FUTURE NEW STARTS 0 0 0 0 0 4 NON-IMMUN-ME 19 14 115 102 190 71 BREEDERS-ME 5 5 5 5 5 0 TOTAL 63 43 575 569 652 257 JAN FEB MAR APR MAY JUN - ------------------------------- GUINEA PIGS - ------------------------------- SBS-ME 0 0 0 0 0 0 CUSTOM-ME 56 58 59 53 70 84 RESERVED 5 3 0 0 0 2 PRESCREENS 0 5 0 0 10 5 FUTURE NEW STARTS 0 0 0 4 0 0 NON-IMMUN-ME 18 6 10 3 4 13 BREEDERS 9 9 7 6 0 0 TOTAL 88 81 76 66 84 104 - ------------------------------- RATS - ------------------------------- SBS-ME 0 0 0 0 0 0 CUSTOM-ME 7 7 16 20 44 63 RESERVED 0 2 8 3 0 0 PRESCREENS 0 0 0 0 0 0 FUTURE NEW STARTS 0 0 2 0 2 10 NON-IMMUN-ME 0 0 0 0 32 0 TOTAL 7 9 26 23 78 73 - ------------------------------- HAMSTERS - ------------------------------- SBS-ME 0 0 0 0 0 0 CUSTOM-ME 0 0 0 0 0 RESERVED 0 0 0 0 0 0 PRESCREENS 0 0 0 0 0 0 FUTURE NEW STARTS 0 0 0 0 0 0 NON-IMMUN-ME 0 0 0 0 0 0 TOTAL 0 0 0 0 0 0 - ------------------------------- FARM TOTAL 10,131 10,031 10,540 10,554 10,771 10,482 - ------------------------------- Delaware Mouse Facility Mice unassigned 2,077 2,529 1,992 3,207 1,874 4,043 Mice-Breeders 1,122 1,041 1,035 1,475 1,730 1,059