2,000,000 SHARES


                                   ENZON, INC.

                          COMMON STOCK, $.01 PAR VALUE








                             UNDERWRITING AGREEMENT










March __, 2000











                                                                  March __, 2000



Morgan Stanley & Co. Incorporated
CIBC World Markets Corp.
SG Cowen Securities Corporation
c/o  Morgan Stanley & Co. Incorporated
1585 Broadway
New York, New York  10036

Dear Sirs and Mesdames:


        ENZON, INC., a Delaware corporation (the "COMPANY"), proposes to issue
and sell to the several Underwriters named in Schedule I hereto (the
"UNDERWRITERS") 2,000,000 shares of its Common Stock, $.01 par value (the "FIRM
SHARES"). The Company also proposes to issue and sell to the several
Underwriters not more than an additional 300,000 shares of Common Stock, $.01
par value, of the Company (the "ADDITIONAL SHARES"), if and to the extent that
you shall have determined to exercise, on behalf of the Underwriters, the right
to purchase such shares of common stock granted to the Underwriters in Section 2
hereof. The Firm Shares and the Additional Shares are hereinafter collectively
referred to as the "SHARES." The shares of Common Stock, $.01 par value, of the
Company to be outstanding after giving effect to the sales contemplated hereby
are hereinafter referred to as the "COMMON STOCK."

        The Company has filed with the Securities and Exchange Commission (the
"COMMISSION") a registration statement on Form S-3 (File No. 333-30818),
including a prospectus, relating to the Shares. The registration statement as
amended at the time it becomes effective, including the information (if any)
deemed to be part of the registration statement at the time of effectiveness
pursuant to Rule 430A under the Securities Act of 1933, as amended (the
"SECURITIES ACT"), is hereinafter referred to as the "REGISTRATION STATEMENT";
the prospectus in the form first used to confirm sales of Shares is hereinafter
referred to as the "PROSPECTUS." The term "preliminary prospectus" as used in
this Agreement shall mean each preliminary prospectus included in the
Registration Statement prior to the time it becomes effective. Unless otherwise
indicated, any reference herein to the Registration Statement, the Prospectus or
the preliminary prospectus shall include all documents incorporated therein by
reference. If the Company has filed an abbreviated registration statement to
register additional shares of Common Stock pursuant to Rule 462(b) under the
Securities Act (the "RULE 462 REGISTRATION STATEMENT"), then any reference
herein to the term "REGISTRATION STATEMENT" shall be deemed to include such Rule
462 Registration Statement.













        1. Representations and Warranties. The Company represents and
warrants to and agrees with each of the Underwriters that:

               (a) The Registration Statement has become effective; no stop
        order suspending the effectiveness of the Registration Statement is in
        effect, and no proceedings for such purpose are pending before or
        threatened by the Commission.

               (b) (i) Each document, if any, filed or to be filed pursuant to
        the Securities Exchange Act of 1934, as amended (the "EXCHANGE ACT"),
        and incorporated by reference in the Prospectus complied, or will comply
        when so filed, in all material respects with the Exchange Act and the
        applicable rules and regulations of the Commission thereunder, (ii) the
        Registration Statement, when it became effective, did not contain and,
        as amended or supplemented, if applicable, will not contain any untrue
        statement of a material fact or omit to state a material fact required
        to be stated therein or necessary to make the statements therein not
        misleading, (iii) the Registration Statement and the Prospectus comply
        and, as amended or supplemented, if applicable, will comply in all
        material respects with the Securities Act and the applicable rules and
        regulations of the Commission thereunder and (iv) the Prospectus does
        not contain and, as amended or supplemented, if applicable, will not
        contain any untrue statement of a material fact or omit to state a
        material fact necessary to make the statements therein, in the light of
        the circumstances under which they were made, not misleading, except
        that the representations and warranties set forth in this paragraph do
        not apply to statements or omissions in the Registration Statement or
        the Prospectus based upon information relating to any Underwriter
        furnished to the Company in writing by such Underwriter through you
        expressly for use therein.

               (c) The Company has been duly incorporated, is validly existing
        as a corporation in good standing under the laws of the State of
        Delaware, has the corporate power and authority to own its property and
        to conduct its business as described in the Prospectus and is duly
        qualified to transact business and is in good standing in each
        jurisdiction in which the conduct of its business or its ownership or
        leasing of property requires such qualification, except to the extent
        that the failure to be so qualified or be in good standing would not
        have a material adverse effect on the Company and its subsidiaries,
        taken as a whole.

               (d) Each subsidiary of the Company has been duly incorporated, is
        validly existing as a corporation in good standing under the laws of the
        jurisdiction of its incorporation, has the corporate power and authority
        to own its property and to conduct its business as described in the
        Prospectus and is duly qualified to transact business and is in good
        standing in each jurisdiction in




                                       3







        which the conduct of its business or its ownership or leasing of
        property requires such qualification, except to the extent that the
        failure to be so qualified or be in good standing would not have a
        material adverse effect on the Company and its subsidiaries, taken as a
        whole; all of the issued shares of capital stock of each subsidiary of
        the Company have been duly and validly authorized and issued, are fully
        paid and non-assessable and are owned directly by the Company, free and
        clear of all liens, encumbrances, equities or claims; Enzon GmbH
        ("GmbH") is the sole non-U.S. subsidiary of the company; GmbH conducts
        no material operations, and the loss of any operations conducted by
        GmbH would not have a material adverse effect on the Company and its
        subsidiaries, taken as a whole.

               (e) This Agreement has been duly authorized, executed and
        delivered by the Company.

               (f) The authorized capital stock of the Company conforms as to
        legal matters to the description thereof contained in the Prospectus.

               (g) The shares of Common Stock outstanding prior to the issuance
        of the Shares have been duly authorized and are validly issued, fully
        paid and non-assessable.

               (h) The Shares have been duly authorized and, when issued and
        delivered in accordance with the terms of this Agreement, will be
        validly issued, fully paid and non-assessable, and the issuance of such
        Shares will not be subject to any preemptive or similar rights.

               (i) The execution and delivery by the Company of, and the
        performance by the Company of its obligations under, this Agreement will
        not contravene, conflict with, result in a breach of any of the terms
        and provisions of, or constitute a default under any provision of
        applicable law or the certificate of incorporation or by-laws of the
        Company and its subsidiaries, taken as a whole, or any agreement or
        other instrument binding upon the Company or any of its subsidiaries
        that is material to the Company and its subsidiaries, taken as a whole,
        or any judgment, order or decree of any governmental body, agency or
        court having jurisdiction over the Company or any subsidiary, and no
        consent, approval, authorization or order of, or qualification with, any
        governmental body or agency is required for the performance by the
        Company of its obligations under this Agreement, except such as may be
        required by the securities or Blue Sky laws of the various states in
        connection with the offer and sale of the Shares.

               (j) There has not occurred any material adverse change, or any
        development involving a prospective material adverse change, in the
        condition, financial or otherwise, or in the earnings, business or
        operations of the Company and its subsidiaries, taken as a whole, from
        that set forth in the Prospectus






                                       4







        (exclusive of any amendments or supplements thereto subsequent to the
        date of this Agreement).

               (k) There are no legal or governmental proceedings pending or
        threatened to which the Company or any of its subsidiaries is a party or
        to which any of the properties of the Company or any of its subsidiaries
        is subject that are required to be described in the Registration
        Statement or the Prospectus and are not so described, or any statutes,
        regulations, contracts or other documents that are required to be
        described in the Registration Statement or the Prospectus or to be filed
        as exhibits to the Registration Statement that are not described or
        filed as required.

               (l) Each preliminary prospectus filed as part of the registration
        statement as originally filed or as part of any amendment thereto, or
        filed pursuant to Rule 424 under the Securities Act, complied when so
        filed in all material respects with the Securities Act and the
        applicable rules and regulations of the Commission thereunder.

               (m) The Company is not and, after giving effect to the offering
        and sale of the Shares and the application of the proceeds thereof as
        described in the Prospectus, will not be required to register as an
        "investment company" as such term is defined in the Investment Company
        Act of 1940, as amended.

               (n) The Company and its subsidiaries (i) are in compliance with
        any and all applicable foreign, federal, state and local laws and
        regulations relating to the protection of human health and safety, the
        environment or hazardous or toxic substances or wastes, pollutants or
        contaminants (including, without limitation, all laws and regulations
        relating to biohazardous substances materials) ("ENVIRONMENTAL LAWS"),
        (ii) have received all permits, licenses or other approvals required of
        them under applicable Environmental Laws to conduct their respective
        businesses and (iii) are in compliance with all terms and conditions of
        any such permit, license or approval, except where such noncompliance
        with Environmental Laws, failure to receive required permits, licenses
        or other approvals or failure to comply with the terms and conditions of
        such permits, licenses or approvals would not, singly or in the
        aggregate, have a material adverse effect on the Company and its
        subsidiaries, taken as a whole.

               (o) There are no costs or liabilities associated with
        Environmental Laws (including, without limitation, any capital or
        operating expenditures required for clean-up, closure of properties or
        compliance with Environmental Laws or any permit, license or approval,
        any related constraints on operating activities and any






                                       5







        potential liabilities to third parties) which would, singly or in the
        aggregate, have a material adverse effect on the Company and its
        subsidiaries, taken as a whole.

               (p) Subsequent to the respective dates as of which information is
        given in the Registration Statement and the Prospectus, (i) the Company
        and its subsidiaries have not incurred any material liability or
        obligation, direct or contingent, nor entered into any material
        transaction not in the ordinary course of business; (ii) the Company has
        not purchased any of its outstanding capital stock, nor declared, paid
        or otherwise made any dividend or distribution of any kind on its
        capital stock other than ordinary and customary dividends; and (iii)
        there has not been any material change in the capital stock, short-term
        debt or long-term debt of the Company and its consolidated subsidiaries,
        except in each case as described in the Prospectus.

               (q) The Company and its subsidiaries have good and marketable
        title in fee simple to all real property and good and marketable title
        to all personal property owned by them which is material to the business
        of the Company and its subsidiaries, in each case free and clear of all
        liens, encumbrances and defects except such as are described in the
        Prospectus or such as do not materially affect the value of such
        property and do not interfere with the use made and proposed to be made
        of such property by the Company and its subsidiaries; and any real or
        personal property and buildings held under lease by the Company and its
        subsidiaries are held by them under valid, subsisting and enforceable
        leases with such exceptions as are not material and do not interfere
        with the use made and proposed to be made of such property and buildings
        by the Company and its subsidiaries, in each case except as described in
        the Prospectus.

               (r) The Company and its subsidiaries are the registered owners of
        all patents and patent applications listed on Exhibit B (the "COMPANY
        PATENTS"), and owns or has the right to use all patent rights, licenses,
        inventions, copyrights, know-how (including trade secrets and other
        unpatented and/or unpatentable proprietary or confidential information,
        systems or procedures), trademarks, service marks and trade names
        ("INTELLECTUAL PROPERTY") currently employed by them in connection with
        the business now operated by them and necessary for the conduct of their
        business as described in Prospectus (the "COMPANY INTELLECTUAL
        PROPERTY"), and, except as described in the Prospectus, neither the
        Company nor any of its subsidiaries has received any notice of any
        infringement of or conflict with the Intellectual Property rights of
        others. Except as disclosed in the prospectus, to the best of the
        Company's knowledge, the manufacture, sale or use of specific products
        or processes referred to in the Prospectus does not infringe upon or
        conflict with the Intellectual Property rights of others.




                                       6







               (s) The Company and its subsidiaries have duly and properly filed
        or caused to be filed with the United States Patent and Trademark Office
        (the "PTO") and applicable foreign and international patent authorities
        all patent applications and all patent applications that resulted in the
        issuance of the patents listed on Exhibit B (the "COMPANY PATENT
        APPLICATIONS"); in connection with the filing of the Company Patent
        Applications, the Company and its subsidiaries conducted reasonable
        investigations of the published literature and patent references
        relating to the inventions claimed in such applications; to the Company
        and its subsidiaries' knowledge, the Company and its subsidiaries have
        complied with the PTO's duty of candor and disclosure for the Company
        Patent Applications and have made no misrepresentation in the Company
        Patent Applications; the Company and its subsidiaries are unaware of any
        facts material to a determination of patentability regarding the Company
        Patent Applications not called to the attention of the PTO; the Company
        and its subsidiaries are unaware of any facts not called to the
        attention of the PTO which would preclude the grant of a patent for the
        Company Patent Applications; and the Company and its subsidiaries have
        no knowledge of any facts which would preclude them from having clear
        title to the Company Patent Applications.

               (t) No material labor dispute with the employees of the Company
        or any of its subsidiaries exists, except as described in or
        contemplated by the Prospectus, or, to the knowledge of the Company, is
        imminent; and the Company is not aware of any existing, threatened or
        imminent labor disturbance by the employees of any of its principal
        suppliers, manufacturers or contractors that could result in any
        material adverse effect on the Company and its subsidiaries, taken as a
        whole.

               (u) The Company and each of its subsidiaries are insured by
        insurers of recognized financial responsibility against such losses and
        risks and in such amounts as are prudent and customary in the businesses
        in which they are engaged; and neither the Company nor any of its
        subsidiaries has been refused any insurance coverage sought or applied
        for.

               (v) Except as set forth in the Prospectus, the Company and its
        subsidiaries possess all certificates, authorizations and permits issued
        by the appropriate federal, state or foreign regulatory authorities
        necessary to conduct their respective businesses, including without
        limitation, all such certificates, authorizations and permits required
        by the United States Food and Drug Administration (the "FDA"), or any
        other federal, state or foreign agencies or bodies engaged in the
        regulation of pharmaceuticals or biohazardous substances; and except as
        set forth in the Prospectus, neither the Company nor any such subsidiary
        has received any notice of proceedings relating to the revocation or





                                       7







        modification of any such certificate, authorization or permit which,
        singly or in the aggregate, if the subject of an unfavorable decision,
        ruling or finding, could result in a material adverse effect on the
        condition, financial or otherwise, or in the earnings, business or
        operations of the Company and its subsidiaries, taken as a whole. Except
        as set forth in the Prospectus, the Company and its subsidiaries are in
        compliance in all material respects with all applicable federal, state,
        local and foreign laws, regulations, orders and decrees, including
        without limitation, all regulations prescribed by the FDA or any other
        federal, state or foreign agencies or bodies engaged in the regulation
        of pharmaceuticals or biohazardous substances, except where
        noncompliance would not, singly or in the aggregate, have a material
        adverse effect on the Company and its subsidiaries, taken as a whole.

               (w) The Company and each of its subsidiaries maintains a system
        of internal accounting controls sufficient to provide reasonable
        assurance that (i) transactions are executed in accordance with
        management's general or specific authorizations; (ii) transactions are
        recorded as necessary to permit preparation of financial statements in
        conformity with generally accepted accounting principles and to maintain
        asset accountability; (iii) access to assets is permitted only in
        accordance with management's general or specific authorization; and (iv)
        the recorded accountability for assets is compared with the existing
        assets at reasonable intervals and appropriate action is taken with
        respect to any differences.

               (x) KPMG LLP are, and during the periods covering their report
        included in the Registration Statement and the Prospectus were,
        independent accountants with respect to the Company as required by the
        Securities Act. The financial statements of the Company and its
        subsidiaries (together with the related notes thereto) included in the
        Registration Statement present fairly the financial position and results
        of operations of the Company and its subsidiaries at the respective
        dates and for the respective periods to which they apply, subject to
        normal year-end adjustments. Such financial statements (together with
        the related notes thereto) have been prepared in accordance with
        generally accepted accounting principles consistently applied throughout
        the periods involved except as otherwise stated therein.

               (y) The Shares have been approved for quotation on the Nasdaq
        National Market, subject to official notice of issuance.

               (z) Except as described in the Prospectus, there are no
        contracts, agreements or understandings between the Company and any
        person granting such person the right to require the Company to file a
        registration statement under





                                       8







        the Securities Act with respect to any securities of the Company or to
        require the Company to include such securities with the Shares
        registered pursuant to the Registration Statement. All persons who
        possess such rights have effectively waived them with respect to the
        offering of the Shares.

               (aa) Each material contract, agreement and license to which the
        Company or any of its subsidiaries is bound is legal, valid, binding,
        enforceable, and in full force and effect. No party is in breach or
        default with respect to any such contract, agreement and license, and no
        event has occurred which with notice or lapse of time would constitute a
        breach or default, or permit termination, modification, or acceleration,
        under any such contract, agreement or license, which would result in a
        material adverse effect on the Company and its subsidiaries, taken as a
        whole. No party has repudiated any provision of any such contract,
        agreement or license, which would result in a material adverse effect on
        the Company and its subsidiaries, taken as a whole.

               (bb) The Company has reviewed its operations and those of its
        subsidiaries and the operations of any third parties with which the
        Company or any of its subsidiaries has a material relationship to
        evaluate the extent to which the business or operations of the Company
        or any of its subsidiaries have been, and in the future will be,
        affected by the Year 2000 Problem (that is, any significant risk that
        computer hardware or software used in the receipt, transmission,
        processing, manipulation, storage, retrieval, retransmission or other
        utilization of data or in the operation of mechanical or electrical
        systems of any kind will not, in the case of dates or time periods
        occurring after December 31, 1999, function at least as effectively as
        in the case of dates or time periods occurring prior to January 1,
        2000). The Year 2000 Problem has not had, and the Company has no reason
        to believe that the Year 2000 Problem will have, a material adverse
        effect on the Company and its subsidiaries, taken as a whole.

        2. Agreements to Sell and Purchase. The Company hereby agrees to sell to
the several Underwriters, and each Underwriter, upon the basis of the
representations and warranties herein contained, but subject to the conditions
hereinafter stated, agrees, severally and not jointly, to purchase from the
Company the respective number of Firm Shares set forth in Schedule I hereto
opposite its name at $_____ a share (the "PURCHASE PRICE").

        On the basis of the representations and warranties contained in this
Agreement, and subject to its terms and conditions, the Company agrees to sell
to the Underwriters the Additional Shares, and the Underwriters shall have a
one-time right to purchase, severally and not jointly, up to 300,000 Additional
Shares at the Purchase Price. If you, on behalf of the Underwriters, elect to
exercise such option, you shall so notify the





                                       9







Company in writing not later than 30 days after the date of this Agreement,
which notice shall specify the number of Additional Shares to be purchased by
the Underwriters and the date on which such shares are to be purchased. Such
date may be the same as the Closing Date (as defined below) but not earlier than
the Closing Date nor later than ten business days after the date of such notice.
Additional Shares may be purchased as provided in Section 4 hereof solely for
the purpose of covering over-allotments made in connection with the offering of
the Firm Shares. If any Additional Shares are to be purchased, each Underwriter
agrees, severally and not jointly, to purchase the number of Additional Shares
(subject to such adjustments to eliminate fractional shares as you may
determine) that bears the same proportion to the total number of Additional
Shares to be purchased as the number of Firm Shares set forth in Schedule I
hereto opposite the name of such Underwriter bears to the total number of Firm
Shares.

        The Company hereby agrees that, without the prior written consent of
Morgan Stanley & Co. Incorporated on behalf of the Underwriters, it will not,
during the period ending 90 days after the date of the Prospectus, (i) offer,
pledge, sell, contract to sell, sell any option or contract to purchase,
purchase any option or contract to sell, grant any option, right or warrant to
purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any
shares of Common Stock or any securities convertible into or exercisable or
exchangeable for Common Stock or (ii) enter into any swap or other arrangement
that transfers to another, in whole or in part, any of the economic consequences
of ownership of the Common Stock, whether any such transaction described in
clause (i) or (ii) above is to be settled by delivery of Common Stock or such
other securities, in cash or otherwise. The foregoing sentence shall not apply
to (A) the Shares to be sold hereunder; (B) the issuance by the Company of
shares of Common Stock upon the exercise of an option or warrant or the
conversion of a security outstanding on the date hereof of which the
Underwriters have been advised in writing; or (C) the issuance of additional
options under the Company's existing stock option plans, provided that such
stock options are not exercisable during such 90-day period.

        3. Terms of Public Offering. The Company is advised by you that the
Underwriters propose to make a public offering of their respective portions of
the Shares as soon after the Registration Statement and this Agreement have
become effective as in your judgment is advisable. The Company is further
advised by you that the Shares are to be offered to the public initially at
$_____ a share (the "PUBLIC OFFERING PRICE") and to certain dealers selected by
you at a price that represents a concession not in excess of $_____ a share
under the Public Offering Price, and that any Underwriter may allow, and such
dealers may reallow, a concession, not in excess of $_____ a share, to any
Underwriter or to certain other dealers.

        4. Payment and Delivery. Payment for the Firm Shares shall be made to
the Company in Federal or other funds immediately available in New York City
against





                                       10







delivery of such Firm Shares for the respective accounts of the several
Underwriters at 10:00 a.m., New York City time, on __________ __, 2000, or at
such other time on the same or such other date, not later than __________ __,
2000, as shall be designated in writing by you. The time and date of such
payment are hereinafter referred to as the "CLOSING DATE". The Closing of the
offering and sale of the Firm Shares will be held at the offices of Ropes &
Gray, One International Place, Boston, MA 02110-2624.

        Payment for any Additional Shares shall be made to the Company in
Federal or other funds immediately available in New York City against delivery
of such Additional Shares for the respective accounts of the several
Underwriters at 10:00 a.m., New York City time, on the date specified in the
notice described in Section 2 or at such other time on the same or on such other
date, in any event not later than __________ __, 2000, as shall be designated in
writing by you. The time and date of such payment are hereinafter referred to as
the "OPTION CLOSING DATE". The Closing of the offering and sale of the
Additional Shares will be held at the offices of Ropes & Gray, One International
Place, Boston, MA 02110-2624.

        Certificates for the Firm Shares and Additional Shares shall be in
definitive form and registered in such names and in such denominations as you
shall request in writing not later than one full business day prior to the
Closing Date or the Option Closing Date, as the case may be. The certificates
evidencing the Firm Shares and Additional Shares shall be delivered to you on
the Closing Date or the Option Closing Date, as the case may be, for the
respective accounts of the several Underwriters, with any transfer taxes payable
in connection with the transfer of the Shares to the Underwriters duly paid,
against payment of the Purchase Price therefor.

        5. Conditions to the Underwriters' Obligations. The obligations of the
Company to sell the Shares to the Underwriters and the several obligations of
the Underwriters to purchase and pay for the Shares on the Closing Date and the
Option Closing Date, as the case may be, are subject to the condition that the
Registration Statement shall have become effective not later than 2:00 p.m. (New
York City time) on the date hereof.

        The several obligations of the Underwriters are subject to the following
further conditions:

               (a) Subsequent to the execution and delivery of this Agreement
        and prior to the Closing Date and the Option Closing Date, as the case
        may be, there shall not have occurred any change, or any development
        involving a prospective change, in the condition, financial or
        otherwise, or in the earnings, business or operations of the Company and
        its subsidiaries, taken as a whole, from that set forth in the
        Prospectus (exclusive of any amendments or supplements thereto
        subsequent to the date of this Agreement) that, in your judgment, is
        material and




                                       11







        adverse and that makes it, in your judgment, impracticable to market the
        Shares on the terms and in the manner contemplated in the Prospectus.

               (b) The Underwriters shall have received on the Closing Date and
        the Option Closing Date, as the case may be, a certificate, dated such
        date and signed by an executive officer of the Company, to the effect
        set forth in Section 5(a)(i) above and to the effect that the
        representations and warranties of the Company contained in this
        Agreement are true and correct as of such date and that the Company has
        complied with all of the agreements and satisfied all of the conditions
        on its part to be performed or satisfied hereunder on or before such
        date.

               The officer signing and delivering such certificate may rely upon
        the best of his or her knowledge as to proceedings threatened.

               (c) The Underwriters shall have received on the Closing Date and
        the Option Closing Date, as the case may be, an opinion of Dorsey &
        Whitney LLP, outside counsel for the Company, dated such date, to the
        effect that:

                      (i) the Company has been duly incorporated, is validly
               existing as a corporation in good standing under the laws of the
               State of Delaware, has the corporate power and authority to own
               its property and to conduct its business as described in the
               Prospectus and is duly qualified to transact business and is in
               good standing in each jurisdiction in which the conduct of its
               business or its ownership or leasing of property requires such
               qualification, except to the extent that the failure to be so
               qualified or be in good standing would not have a material
               adverse effect on the Company and its subsidiaries, taken as a
               whole;

                      (ii) each subsidiary of the Company has been duly
               organized, is validly existing as a corporation in good standing
               under the laws of the jurisdiction of its organization, has the
               corporate power and authority to own its property and to conduct
               its business as described in the Prospectus and is duly qualified
               to transact business and is in good standing in each jurisdiction
               in which the conduct of its business or its ownership or leasing
               of property requires such qualification, except to the extent
               that the failure to be so qualified or be in good standing would
               not have a material adverse effect on the Company and its
               subsidiaries, taken as a whole;

                      (iii) the authorized capital stock of the Company conforms
               as to legal matters to the description thereof contained in the
               Prospectus;




                                       12







                      (iv) the shares of Common Stock outstanding prior to the
               issuance of the Shares have been duly authorized and are validly
               issued, fully paid and non-assessable;

                      (v) all of the issued shares of capital stock of each
               subsidiary of the Company have been duly and validly authorized
               and issued, are fully paid and non-assessable and, to the best of
               our knowledge, are owned directly by the Company, free and clear
               of all liens, encumbrances, or claims;

                      (vi) the Underwriting Agreement has been duly authorized,
               executed and delivered by the Company;

                      (vii) the Shares have been duly authorized and, when
               issued and delivered in accordance with terms of the Underwriting
               Agreement, will be validly issued, fully paid and non-assessable,
               and the issuance of the Shares will not be subject to any
               preemptive or similar rights under any provision of applicable
               law, the articles of incorporation or by-laws of the Company or,
               to the best of our knowledge, any other agreement of instrument
               binding on the Company and its subsidiaries;

                      (viii) the statements (A) in the Prospectus under the
               captions "Business -Strategic Alliances and Licenses -
               Schering-Plough Agreement," "Business - Strategic Alliances and
               Licenses - Rhone- Poulenc Licence Agreement," and "Description of
               Capital Stock," and (B) in the Registration Statement in Item 15,
               in each case insofar as such statements constitute summaries of
               the legal matters or documents referred to therein, fairly
               present the information called for with respect to such legal
               matters and documents and fairly summarize the matters referred
               to therein;

                      (ix) the execution and delivery by the Company of, and the
               performance by the Company of its obligations under, the
               Underwriting Agreement will not contravene any provision of
               applicable law or conflict with, result in a breach of any of the
               terms and provisions of, or constitute a default under, the
               articles of incorporation or by-laws of the Company or, to the
               best of our knowledge, any agreement or other instrument binding
               upon the Company or any of its subsidiaries that is material to
               the Company and its subsidiaries, taken as a whole, or, to the
               best of our knowledge, any judgment, order or decree of any
               governmental body, agency or court having jurisdiction over the
               Company or any subsidiary, and no consent, approval,
               authorization or order of, or qualification with,




                                       13







               any governmental body or agency is required for the performance
               by the Company of its obligations under the Underwriting
               Agreement, except such as may be required by the securities or
               Blue Sky laws of the various states in connection with the offer
               and sale of the Shares;

                      (x) to the best of our knowledge, there are no legal or
               governmental proceedings pending or threatened to which the
               Company or any of its subsidiaries is a party or to which any of
               the properties of the Company or any of its subsidiaries is
               subject that are required to be described in the Registration
               Statement or the Prospectus and are not so described, or any
               statutes, regulations, contracts or other documents that are
               required to be described in the Registration Statement or the
               Prospectus or to be filed as exhibits to the Registration
               Statement that are not described or filed as required;

                      (xi) the Company is not and, after giving effect to the
               offering and sale of the Shares and the application of the
               proceeds thereof as described in the Prospectus, will not be an
               "investment company" as such term is defined in the Investment
               Company Act of 1940, as amended;

                      (xii) except as described in the Prospectus, agreements or
               understandings between the Company and any person granting such
               person the right to require the Company to file a registration
               statement under the Act with respect to any securities of the
               Company or to require the Company to include such securities with
               the Shares registered pursuant to the Registration Statement, and
               all persons who possess such rights have effectively waived them
               with respect to the offering of the Shares;

                      (xiii) the Registration Statement has become effective
               and, to the best of our knowledge, no stop order suspending the
               effectiveness of the Registration Statement is in effect, and no
               proceedings for such purpose are pending before or threatened by
               the Commission;

                      (xiv) the Shares have been approved for quotation on the
               Nasdaq National Market, subject to official notice of issuance.

                      (xv)  each document, if any, filed pursuant to the
               Exchange Act and incorporated by reference in the Registration
               Statement and the Prospectus (except for financial statements and
               schedules and other financial and statistical data included
               therein as to which such counsel need not express any opinion)
               complied when so filed as to form in all material respects with
               the Exchange Act, and the applicable rules and regulations of
               the Commission thereunder; and the Registration Statement and
               Prospectus (except for financial statements and schedules and
               other financial and statistical data included therein as to
               which such counsel need not express any opinion) comply as to
               form in all material respects with the Securities Act and the
               applicable rules and regulations of the Commission thereunder,

               (d) The Underwriters shall receive on the Closing Date and the
        Option Closing Date, a letter from Dorsey & Whitney LLP, outside counsel
        to the Company dated such date, to the effect that:




                                       14





               such counsel has no reason to believe that (except for financial
               statements and schedules and other financial and statistical data
               as to which such counsel need not express any belief) the
               Registration Statement and the prospectus included therein at the
               time the Registration Statement became effective contained any
               untrue statement of a material fact or omitted to state a
               material fact required to be stated therein or necessary to make
               the statements therein not misleading and (except for financial
               statements and schedules and other financial and statistical data
               as to which such counsel need not express any belief) the
               Prospectus contains any untrue statement of a material fact or
               omits to state a material fact necessary in order to make the
               statements therein, in the light of the circumstances under which
               they were made, not misleading.

               (e) The Underwriters shall receive on the Closing Date and the
        Option Closing Date, a letter from Dorsey & Whitney LLP, patent counsel
        to the Company, dated such date in a form satisfactory to the
        Underwriters.

               (f) The Underwriters shall have received on the Closing Date and
        the Option Closing Date, as the case may be, an opinion of Sterne,
        Kessler, Goldstein & Fox P.L.L.C., patent counsel for the Company, dated
        such date, and an opinion of Roberts & Mercanti, L.L.P., a patent
        counsel to the Company, dated such date, in a form satisfactory to the
        Underwriters.

               (g) The Underwriters shall have received on the Closing Date and
        the Option Closing Date, as the case may be, an opinion of Ropes & Gray,
        counsel for the Underwriters, dated such date, in a form satisfactory to
        the Underwriters.

               With respect to Sections 5(c)(xv) and 5(d) above, Dorsey &
        Whitney LLP may state that its opinion and belief are based upon its
        participation in the preparation of the relevant portions of the
        Registration Statement and Prospectus and any amendments or supplements
        thereto and documents incorporated by reference and review and





                                       15







        discussion of the contents thereof, but are without independent check or
        verification except as specified.

               The opinions of Dorsey & Whitney LLP, Sterne, Kessler, Goldstein
        & Fox P.L.L.C., and Roberts & Mercanti, L.L.P. described in Sections
        5(c), 5(d), 5(e) and 5(f) above shall be rendered to the Underwriters at
        the request of the Company and shall so state therein.

               (h) The Underwriters shall have received, on each of the date
        hereof, the Closing Date and the Option Closing Date, a letter dated
        such date, in form and substance satisfactory to the Underwriters, from
        KPMG LLP, independent public accountants, containing statements and
        information of the type ordinarily included in accountants' "comfort
        letters" to underwriters with respect to the financial statements and
        certain financial information contained in or incorporated by reference
        into the Registration Statement and the Prospectus; provided that the
        letter delivered on the Closing Date shall use a "cut-off date" not
        earlier than the date hereof.

               (i) The "lock-up" agreements, each substantially in the form of
        Exhibit A hereto, between you and certain shareholders, officers and
        directors of the Company relating to sales and certain other
        dispositions of shares of Common Stock or certain other securities,
        delivered to you on or before the date hereof, shall be in full force
        and effect on the Closing Date and the Option Closing Date, as the case
        may be.

               The several obligations of the Underwriters to purchase
        Additional Shares hereunder are subject to the delivery to you on the
        Option Closing Date of such other documents as you may reasonably
        request with respect to the good standing of the Company, the due
        authorization and issuance of the Additional Shares and other matters
        related to the issuance of the Additional Shares.

        6. Covenants of the Company. In further consideration of the agreements
of the Underwriters herein contained, the Company covenants with each
Underwriter as follows:

               (a) To furnish to you, without charge, four signed copies of the
        Registration Statement (including exhibits thereto and documents
        incorporated by reference) and for delivery to each other Underwriter a
        conformed copy of the Registration Statement (without exhibits thereto
        but including documents incorporated by reference) and to furnish to you
        in New York City, without charge, prior to 10:00 a.m. New York City time
        on the business day next succeeding the date of this Agreement and
        during the period mentioned in





                                       16







        Section 6(c) below, as many copies of the Prospectus, any documents
        incorporated by reference, and any supplements and amendments thereto or
        to the Registration Statement as you may reasonably request. The terms
        "supplement" and "amendment" or "amend" as used in this Agreement shall
        include all documents subsequently filed by the Company with the
        Commission pursuant to the Exchange Act that are deemed to be
        incorporated by reference in the Prospectus.

               (b) Before amending or supplementing the Registration Statement
        or the Prospectus, to furnish to you a copy of each such proposed
        amendment or supplement and not to file any such proposed amendment or
        supplement to which you reasonably object, and to file with the
        Commission within the applicable period specified in Rule 424(b) under
        the Securities Act any prospectus required to be filed pursuant to such
        Rule.

               (c) If, during such period after the first date of the public
        offering of the Shares as in the opinion of counsel for the Underwriters
        the Prospectus is required by law to be delivered in connection with
        sales by an Underwriter or dealer, any event shall occur or condition
        exist as a result of which it is necessary to amend or supplement the
        Prospectus in order to make the statements therein, in the light of the
        circumstances when the Prospectus is delivered to a purchaser, not
        misleading, or if, in the opinion of counsel for the Underwriters, it is
        necessary to amend or supplement the Prospectus to comply with
        applicable law, forthwith to prepare, file with the Commission and
        furnish, at its own expense, to the Underwriters and to the dealers
        (whose names and addresses you will furnish to the Company) to which
        Shares may have been sold by you on behalf of the Underwriters and to
        any other dealers upon request, either amendments or supplements to the
        Prospectus so that the statements in the Prospectus as so amended or
        supplemented will not, in the light of the circumstances when the
        Prospectus is delivered to a purchaser, be misleading or so that the
        Prospectus, as amended or supplemented, will comply with law.

               (d) To endeavor to qualify the Shares for offer and sale under
        the securities or Blue Sky laws of such jurisdictions as you shall
        reasonably request.

               (e) To make generally available to the Company's security holders
        and to you as soon as practicable an earning statement covering the
        twelve-month period ending March 31, 2001 that satisfies the provisions
        of Section 11(a) of the Securities Act and the rules and regulations of
        the Commission thereunder.

        7. Expenses. Whether or not the transactions contemplated in this
Agreement are consummated or this Agreement is terminated, the Company agrees to
pay or cause to be




                                       17







paid all expenses incident to the performance of its obligations under this
Agreement, including: (i) the fees, disbursements and expenses of the Company's
counsel and the Company's accountants in connection with the registration and
delivery of the Shares under the Securities Act and all other fees or expenses
in connection with the preparation and filing of the Registration Statement, any
preliminary prospectus, the Prospectus and amendments and supplements to any of
the foregoing, including all printing costs associated therewith, and the
mailing and delivering of copies thereof to the Underwriters and dealers, in the
quantities hereinabove specified, (ii) all costs and expenses related to the
transfer and delivery of the Shares to the Underwriters, including any transfer
or other taxes payable thereon, (iii) the cost of printing or producing any Blue
Sky or Legal Investment memorandum in connection with the offer and sale of the
Shares under state securities laws and all expenses in connection with the
qualification of the Shares for offer and sale under state securities laws as
provided in Section 6(d) hereof, including filing fees and the reasonable fees
and disbursements of counsel for the Underwriters in connection with such
qualification and in connection with the Blue Sky or Legal Investment
memorandum, (iv) all filing fees and the reasonable fees and disbursements of
counsel to the Underwriters incurred in connection with the review and
qualification of the offering of the Shares by the National Association of
Securities Dealers, Inc., (v) all costs and expenses incident to listing the
Shares on the Nasdaq National Market, (vi) the cost of printing certificates
representing the Shares, (vii) the costs and charges of any transfer agent,
registrar or depositary, (viii) the costs and expenses of the Company relating
to investor presentations on any "road show" undertaken in connection with the
marketing of the offering of the Shares, including, without limitation, expenses
associated with the production of road show slides and graphics, fees and
expenses of any consultants engaged in connection with the road show
presentations with the prior approval of the Company, travel and lodging
expenses of the representatives and officers of the Company and any such
consultants, and the cost of any aircraft chartered in connection with the road
show, and (ix) all other costs and expenses incident to the performance of the
obligations of the Company hereunder for which provision is not otherwise made
in this Section. It is understood, however, that except as provided in this
Section, Section 8 entitled "Indemnity and Contribution", and the last paragraph
of Section 10 below, the Underwriters will pay all of their costs and expenses,
including fees and disbursements of their counsel, stock transfer taxes payable
on resale of any of the Shares by them and any advertising expenses connected
with any offers they may make.

        8.  Indemnity and Contribution.

               (a) The Company agrees to indemnify and hold harmless each
        Underwriter and each person, if any, who controls any Underwriter within
        the meaning of either Section 15 of the Securities Act or Section 20 of
        the Exchange Act, from and against any and all losses, claims, damages
        and liabilities (including, without limitation, any legal or other
        expenses reasonably incurred in




                                       18







        connection with defending or investigating any such action or claim)
        caused by any untrue statement or alleged untrue statement of a material
        fact contained in the Registration Statement or any amendment thereof,
        any preliminary prospectus or the Prospectus (as amended or supplemented
        if the Company shall have furnished any amendments or supplements
        thereto), or caused by any omission or alleged omission to state therein
        a material fact required to be stated therein or necessary to make the
        statements therein not misleading, except insofar as such losses,
        claims, damages or liabilities are caused by any such untrue statement
        or omission or alleged untrue statement or omission based upon
        information relating to any Underwriter furnished to the Company in
        writing by such Underwriter through you expressly for use therein;
        provided, however, that the foregoing indemnity agreement with respect
        to any preliminary prospectus shall not inure to the benefit of any
        Underwriter from whom the person asserting any such losses, claims,
        damages or liabilities purchased Shares, or any person controlling such
        Underwriter, if a copy of the Prospectus (as then amended or
        supplemented if the Company shall have furnished any amendments or
        supplements thereto) was not sent or given by or on behalf of such
        Underwriter to such person, if required by law so to have been
        delivered, at or prior to the written confirmation of the sale of the
        Shares to such person, and if the Prospectus (as so amended or
        supplemented) would have cured the defect giving rise to such losses,
        claims, damages or liabilities, unless such failure is the result of
        noncompliance by the Company with Section 6(a) hereof.

               (b) Each Underwriter agrees, severally and not jointly, to
        indemnify and hold harmless the Company, its directors, its officers who
        sign the Registration Statement and each person, if any, who controls
        the Company within the meaning of either Section 15 of the Securities
        Act or Section 20 of the Exchange Act to the same extent as the
        foregoing indemnity from the Company to such Underwriter, but only with
        reference to information relating to such Underwriter furnished to the
        Company in writing by such Underwriter through you expressly for use in
        the Registration Statement, any preliminary prospectus, the Prospectus
        or any amendments or supplements thereto.

               (c) In case any proceeding (including any governmental
        investigation) shall be instituted involving any person in respect of
        which indemnity may be sought pursuant to Section 8(a), or 8(b) such
        person (the "INDEMNIFIED PARTY") shall promptly notify the person
        against whom such indemnity may be sought (the "INDEMNIFYING PARTY") in
        writing and the indemnifying party, upon request of the indemnified
        party, shall retain counsel reasonably satisfactory to the indemnified
        party to represent the indemnified party and any others the indemnifying
        party may designate in such proceeding and shall pay the fees and
        disbursements of such counsel related to such proceeding. In any such
        proceeding, any indemnified




                                       19







        party shall have the right to retain its own counsel, but the fees and
        expenses of such counsel shall be at the expense of such indemnified
        party unless (i) the indemnifying party and the indemnified party shall
        have mutually agreed to the retention of such counsel or (ii) the named
        parties to any such proceeding (including any impleaded parties) include
        both the indemnifying party and the indemnified party and representation
        of both parties by the same counsel would be inappropriate due to actual
        or potential differing interests between them. It is understood that the
        indemnifying party shall not, in respect of the legal expenses of any
        indemnified party in connection with any proceeding or related
        proceedings in the same jurisdiction, be liable for the fees and
        expenses of more than one separate firm (in addition to any local
        counsel) for all such indemnified parties and that all such fees and
        expenses shall be reimbursed as they are incurred. Such firm shall be
        designated in writing by Morgan Stanley & Co. Incorporated, in the case
        of parties indemnified pursuant to Section 8(a), and by the Company, in
        the case of parties indemnified pursuant to Section 8(b). The
        indemnifying party shall not be liable for any settlement of any
        proceeding effected without its written consent, but if settled with
        such consent or if there be a final judgment for the plaintiff, the
        indemnifying party agrees to indemnify the indemnified party from and
        against any loss or liability by reason of such settlement or judgment.
        No indemnifying party shall, without the prior written consent of the
        indemnified party, effect any settlement of any pending or threatened
        proceeding in respect of which any indemnified party is or could have
        been a party and indemnity could have been sought hereunder by such
        indemnified party, unless such settlement includes an unconditional
        release of such indemnified party from all liability on claims that are
        the subject matter of such proceeding.

               (d) To the extent the indemnification provided for in Section
        8(a) or 8(b) is applicable by its terms but unavailable to an
        indemnified party or insufficient in respect of any losses, claims,
        damages or liabilities referred to therein, then each indemnifying party
        under such paragraph, in lieu of indemnifying such indemnified party
        thereunder, shall contribute to the amount paid or payable by such
        indemnified party as a result of such losses, claims, damages or
        liabilities (i) in such proportion as is appropriate to reflect the
        relative benefits received by the Company on the one hand and the
        Underwriters on the other hand from the offering of the Shares or (ii)
        if the allocation provided by clause (i) of this sentence is not
        permitted by applicable law, in such proportion as is appropriate to
        reflect not only the relative benefits referred to in clause (i) of this
        sentence but also the relative fault of the Company on the one hand and
        of the Underwriters on the other hand in connection with the statements
        or omissions that resulted in such losses, claims, damages or
        liabilities, as well as any other relevant equitable considerations. The
        relative benefits received by the Company on the one hand




                                       20







        and the Underwriters on the other hand in connection with the offering
        of the Shares shall be deemed to be in the same respective proportions
        as the net proceeds from the offering of the Shares (before deducting
        expenses) received by the Company and the total underwriting discounts
        and commissions received by the Underwriters, in each case as set forth
        in the table on the cover of the Prospectus, bear to the aggregate
        Public Offering Price of the Shares. The relative fault of the Company
        on the one hand and the Underwriters on the other hand shall be
        determined by reference to, among other things, whether the untrue or
        alleged untrue statement of a material fact or the omission or alleged
        omission to state a material fact relates to information supplied by the
        Company or by the Underwriters and the parties' relative intent,
        knowledge, access to information and opportunity to correct or prevent
        such statement or omission. The Underwriters' respective obligations to
        contribute pursuant to this Section 8 are several in proportion to the
        respective number of Shares they have purchased hereunder, and not
        joint.

               (e) The Company and the Underwriters agree that it would not be
        just or equitable if contribution pursuant to this Section 8 were
        determined by pro rata allocation (even if the Underwriters were treated
        as one entity for such purpose) or by any other method of allocation
        that does not take account of the equitable considerations referred to
        in Section 8(d). The amount paid or payable by an indemnified party as a
        result of the losses, claims, damages and liabilities referred to in the
        immediately preceding paragraph shall be deemed to include, subject to
        the limitations set forth above, any legal or other expenses reasonably
        incurred by such indemnified party in connection with investigating or
        defending any such action or claim. Notwithstanding the provisions of
        this Section 8, no Underwriter shall be required to contribute any
        amount in excess of the amount by which the total price at which the
        Shares underwritten by it and distributed to the public were offered to
        the public exceeds the amount of any damages that such Underwriter has
        otherwise been required to pay by reason of such untrue or alleged
        untrue statement or omission or alleged omission. No person guilty of
        fraudulent misrepresentation (within the meaning of Section 11(f) of the
        Securities Act) shall be entitled to contribution from any person who
        was not guilty of such fraudulent misrepresentation. The remedies
        provided for in this Section 8 are not exclusive and shall not limit any
        rights or remedies which may otherwise be available to any indemnified
        party at law or in equity.

               (f) The indemnity and contribution provisions contained in this
        Section 8 and the representations, warranties and other statements of
        the Company contained in this Agreement shall remain operative and in
        full force and effect regardless of (i) any termination of this
        Agreement, (ii) any investigation made by or on behalf of any
        Underwriter or any person controlling any Underwriter or by





                                       21







        or on behalf of the Company, its officers or directors or any person
        controlling the Company and (iii) acceptance of and payment for any of
        the Shares.

        9. Termination. This Agreement shall be subject to termination by notice
given by you to the Company, if (a) after the execution and delivery of this
Agreement and prior to the Closing Date (i) trading generally shall have been
suspended or materially limited on or by, as the case may be, any of the New
York Stock Exchange, the American Stock Exchange, the National Association of
Securities Dealers, Inc., the Chicago Board of Options Exchange, the Chicago
Mercantile Exchange or the Chicago Board of Trade, (ii) trading of any
securities of the Company shall have been suspended on any exchange or in any
over-the-counter market, (iii) a general moratorium on commercial banking
activities in New York shall have been declared by either Federal or New York
State authorities or (iv) there shall have occurred any outbreak or escalation
of hostilities or any change in financial markets or any calamity or crisis
that, in your judgment, is material and adverse and (b) in the case of any of
the events specified in clauses (i) through (iv) above, such event, singly or
together with any other such event, makes it, in your judgment, impracticable to
market the Shares on the terms and in the manner contemplated in the Prospectus.

        10. Effectiveness; Defaulting Underwriters. This Agreement shall become
effective upon the execution and delivery hereof by the parties hereto.

        If, on the Closing Date or the Option Closing Date, as the case may be,
any one or more of the Underwriters shall fail or refuse to purchase Shares that
it has or they have agreed to purchase hereunder on such date, and the aggregate
number of Shares which such defaulting Underwriter or Underwriters agreed but
failed or refused to purchase is not more than one-tenth of the aggregate number
of the Shares to be purchased on such date, the other Underwriters shall be
obligated severally in the proportions that the number of Firm Shares set forth
opposite their respective names in Schedule I bears to the aggregate number of
Firm Shares set forth opposite the names of all such non-defaulting
Underwriters, or in such other proportions as you may specify, to purchase the
Shares which such defaulting Underwriter or Underwriters agreed but failed or
refused to purchase on such date; provided that in no event shall the number of
Shares that any Underwriter has agreed to purchase pursuant to this Agreement be
increased pursuant to this Section 10 by an amount in excess of one-ninth of
such number of Shares without the written consent of such Underwriter. If, on
the Closing Date, any Underwriter or Underwriters shall fail or refuse to
purchase Firm Shares and the aggregate number of Firm Shares with respect to
which such default occurs is more than one-tenth of the aggregate number of Firm
Shares to be purchased, and arrangements satisfactory to you and the Company for
the purchase of such Firm Shares are not made within 36 hours after such
default, this Agreement shall terminate without liability on the part of any
non-defaulting Underwriter or the Company. In any such case either you or the
Company





                                       22






shall have the right to postpone the Closing Date, but in no event for longer
than seven days, in order that the required changes, if any, in the Registration
Statement and in the Prospectus or in any other documents or arrangements may be
effected. If, on the Option Closing Date, any Underwriter or Underwriters shall
fail or refuse to purchase Additional Shares and the aggregate number of
Additional Shares with respect to which such default occurs is more than
one-tenth of the aggregate number of Additional Shares to be purchased, the
non-defaulting Underwriters shall have the option to (i) terminate their
obligation hereunder to purchase Additional Shares or (ii) purchase not less
than the number of Additional Shares that such non-defaulting Underwriters would
have been obligated to purchase in the absence of such default. Any action taken
under this paragraph shall not relieve any defaulting Underwriter from liability
in respect of any default of such Underwriter under this Agreement.

        If this Agreement shall be terminated by the Underwriters, or any of
them, because of any failure or refusal on the part of the Company to comply
with the terms or to fulfill any of the conditions of this Agreement, or if for
any reason the Company shall be unable to perform its obligations under this
Agreement, the Company will reimburse the Underwriters or such Underwriters as
have so terminated this Agreement with respect to themselves, severally, for all
out-of-pocket expenses (including the fees and disbursements of their counsel)
reasonably incurred by such Underwriters in connection with this Agreement or
the offering contemplated hereunder.

        11. Counterparts. This Agreement may be signed in two or more
counterparts, each of which shall be an original, with the same effect as if the
signatures thereto and hereto were upon the same instrument.

        12. Applicable Law. This Agreement shall be governed by and construed in
accordance with the internal laws of the State of New York.

        13. Headings. The headings of the sections of this Agreement have been
inserted for convenience of reference only and shall not be deemed a part of
this Agreement.





                                       23







                                                        [Underwriting Agreement]


                                    Very truly yours,

                                    ENZON, INC.



                                    By:
                                       -----------------------------------
                                        Name:
                                        Title:


Accepted as of the date hereof

Morgan Stanley & Co. Incorporated
CIBC World Markets Corp.
SG Cowen Securities Corporation

Acting severally on behalf of
  themselves and the several
  Underwriters named in
  Schedule I hereto.

By: Morgan Stanley & Co. Incorporated


        By:
           ---------------------------------
               Name:
               Title:


















                                      SCHEDULE I



                                                          NUMBER OF
                                                          FIRM SHARES
           UNDERWRITER                                    TO BE PURCHASED
           -----------                                    ---------------

Morgan Stanley & Co. Incorporated
CIBC World Markets Corp.
SG Cowen Securities Corporation



                                                       -------------
Total.......................................
                                                       -------------













                                                                   EXHIBIT A




                               [FORM OF LOCK-UP LETTER]




                                                              February __, 2000


Morgan Stanley & Co. Incorporated
SG Cowen Securities Corporation
CIBC World Markets Corp.
c/o Morgan Stanley & Co. Incorporated
1585 Broadway
New York, NY  10036

Dear Sirs and Mesdames:

      The undersigned understands that Morgan Stanley & Co. Incorporated
("MORGAN STANLEY") proposes to enter into an Underwriting Agreement (the
"UNDERWRITING AGREEMENT") with Enzon, Inc., a Delaware corporation (the
"COMPANY"), providing for the public offering (the "PUBLIC OFFERING") by the
several Underwriters, including Morgan Stanley (the "UNDERWRITERS"), of up to
______________ shares (the "SHARES") of the Common Stock, $.01 par value, of the
Company (the "COMMON STOCK").

      To induce the Underwriters that may participate in the Public Offering to
continue their efforts in connection with the Public Offering, the undersigned
hereby agrees that, without the prior written consent of Morgan Stanley on
behalf of the Underwriters, it will not, during the period commencing on the
date hereof and ending 90 days after the date of the final prospectus relating
to the Public Offering (the "PROSPECTUS"), (1) offer, pledge, sell, contract to
sell, sell any option or contract to purchase, purchase any option or contract
to sell, grant any option, right or warrant to purchase, lend, or otherwise
transfer or dispose of, directly or indirectly, any shares of Common Stock or
any securities convertible into or exercisable or exchangeable for Common Stock
or (2) enter into any swap or other arrangement that transfers to another, in
whole or in part, any of the economic consequences of ownership of the Common
Stock, whether any such transaction described in clause (1) or (2) above is to
be settled by delivery of Common Stock or such other securities, in cash or
otherwise. The foregoing sentence shall not apply to transactions relating to
shares of Common Stock or other securities acquired in open market transactions
after the completion of the Public Offering. In addition, the undersigned agrees
that, without the prior written consent of













Morgan Stanley on behalf of the Underwriters, it will not, during the period
commencing on the date hereof and ending 90 days after the date of the
Prospectus, make any demand for or exercise any right with respect to, the
registration of any shares of Common Stock or any security convertible into or
exercisable or exchangeable for Common Stock.

      This agreement and the obligations of the undersigned hereunder shall be
terminated if the registration statement to be filed by the Company, relating to
the Shares of Common Stock in the Public Offering, is not declared effective by
the Securities Exchange Commission on or before June 30, 2000.

      Whether or not the Public Offering actually occurs depends on a number of
factors, including market conditions. Any Public Offering will only be made
pursuant to an Underwriting Agreement, the terms of which are subject to
negotiation between the Company and the Underwriters.


                                                        Very truly yours,

                                                        -----------------------
                                                        (Name)

                                                        -----------------------
                                                        (Address)













                                                                      EXHIBIT B

                                   "Company Patents"
                                    ---------------

       Patents and patent applications owned by the Company:


Number                               Title                         Date
- ------                               -----                         ----