THE SECURITIES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT BEEN REGISTERED UNDER
THE  SECURITIES  ACT OF 1933,  AS  AMENDED,  AND MAY NOT BE  SOLD,  TRANSFERRED,
PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF REGISTRATION OR
THE AVAILABILITY OF AN EXEMPTION FROM REGISTRATION UNDER SAID ACT.

Warrant to Purchase
105,000 shares


                        Warrant to Purchase Common Stock
                                       of
                              CELGENE CORPORATION

         THIS  CERTIFIES  that  Swartz  Investments,   Inc.  ('Holder')  or  any
subsequent holder hereof, has the right to purchase from Celgene Corporation,  a
Delaware  corporation  (the  'Company'),  not more than  105,000  fully paid and
nonassessable  shares of the Company's  Common  Stock,  par value $.01 per share
('Common  Stock'),  at a price of $9.60  per  share  subject  to  adjustment  as
provided  in Section 4 below (the  'Exercise  Price'),  at any time on or before
5:00 p.m., Atlanta, Georgia time, on July 31, 2000.

         The holder of this Warrant agrees with the Company that this Warrant is
issued and all rights  hereunder shall be held subject to all of the conditions,
limitations and provisions set forth herein.

         1.       Exercise.

         This Warrant may be  exercised  as to all or any lesser  number of full
shares of Common Stock covered hereby upon  surrender of this Warrant,  with the
Subscription Form attached hereto duly executed, together with the full Exercise
Price (as  hereinafter  defined) in cash, or by certified or official bank check
payable in New York  Clearing  House Funds for each share of Common  Stock as to
which this Warrant is  exercised,  at the office of the  Company,  7 Powder Horn
Drive,  Warren, N.J. 07059, or at such other office or agency as the Company may
designate  in  writing,   by  overnight  mail,  with  an  advance  copy  of  the
Subscription  Form by facsimile (such surrender and payment  hereinafter  called
the 'exercise of this Warrant').  The 'Date of Exercise' of the Warrant shall be
defined  as the  date set  forth  in the  Subscription  Form  provided  that the
original Warrant and  Subscription  Form are received by the Company within five
business days thereafter.  The original  Warrant and  Subscription  Form must be
received  within five days of the Date of  Exercise,  or the  Subscription  Form
shall be considered void. This Warrant shall be canceled upon its exercise, and,
as soon as practical thereafter,  the holder hereof shall be entitled to receive
a certificate or certificates for the number of shares of Common Stock purchased
upon such exercise and a new Warrant or Warrants  (containing terms identical to
this Warrant)  representing any unexercised portion of this Warrant. Each person
in whose name any  certificate  for shares of Common Stock is issued shall,  for
all




purposes,  be deemed to have  become the holder of record of such  shares on the
Date of Exercise of this Warrant,  irrespective  of the date of delivery of such
certificate. The person in whose name this Warrant is registered shall be deemed
the owner therof and of the Warrant  evidenced hereby for all purposes.  Nothing
in this  Warrant  shall be construed as  conferring  upon the holder  hereof any
rights as a shareholder of the Company.

         2.       Payment of Warrant Price.

         Payment of the Exercise Price may be made by any of the following, or a
combination thereof, at the election of Holder:

         (i)      cash, check or wire transfer; or

         (ii)  surrender of this Warrant at the principal  office of the Company
together with notice of election,  in which event the Company shall issue Holder
a number of shares of Common Stock computed using the following formula:

                           X = Y (A-B)/A

where:   X = the number of shares of Common Stock to be issued to Holder.

         Y = the number of shares of Common Stock for which this Warrant
             is exercisable.

                  A = the  Market  Price  of one  share  of  Common  Stock  (for
                  purposes of this Section  2(ii),  the 'Market  Price' shall be
                  defined as the closing  bid price of the Common  Stock for the
                  five  trading  days  prior  to the  Date of  Exercise  of this
                  Warrant, as reported by the National Association of Securities
                  Dealers  Automated  Quotation  System  ('NASDAQ'),  or if  the
                  Common Stock is not traded on NASDAQ, the closing bid price in
                  the over-the-counter  market;  provided,  however, that if the
                  Common Stock is listed on a stock  exchange,  the Market Price
                  shall be the closing price on such exchange).

                  B = the Exercise Price.

         3.       Transfer and Registration.

         Subject to the  provisions of Section 7 of this  Warrant,  this Warrant
may be transferred on the books of the Company,  wholly or in part, in person or
by attorney,  upon surrender of this Warrant properly  endorsed,  with signature
guaranteed.  This Warrant shall be canceled upon such  surrender and, as soon as
practicable  thereafter,  the  person to whom  such  transfer  is made  shall be
entitled to receive a new Warrant or Warrants as to the portion of this  Warrant
transferred,  and the holder of this Warrant  shall be entitled to receive a new
Warrant or Warrants as to the portion hereof retained.




         4.       Anti-Dilution Adjustments.

         (a) If the  Company  shall at any time  declare a  dividend  payable in
shares of Common Stock,  then the holder  hereof,  upon exercise of this Warrant
after the record date for the  determination of holders of Common Stock entitled
to receive such  dividend,  shall be entitled to receive  upon  exercise of this
Warrant,  in addition  to the number of shares of Common  Stock as to which this
Warrant is  exercised,  such  additional  shares of Common  Stock as such holder
would have received had this Warrant been  exercised  immediately  prior to such
record date.

         (b) If the  Company  shall at any time  effect  a  recapitalization  or
reclassification  of such  character  that the shares of Common  Stock  shall be
changed into or become  exchangeable  for a larger or smaller  number of shares,
then upon the effective date thereof, the number of shares of Common Stock which
the holder  hereof shall be entitled to purchase  upon  exercise of this Warrant
shall be increased or decreased, as the case may be, in direct proportion to the
increase or  decrease in the number of shares of Common  Stock by reason of such
recapitalization  or  reclassification,  and the Exercise Price shall be, in the
case of an increase in the number of shares,  proportionately  decreased and, in
the case of a decrease in the number of shares, proportionally increased.

         (c) If the Company  shall at any time  distribute  to holders of Common
Stock cash,  evidences of indebtedness or other securities or assets (other than
cash dividends or distributions payable out of earned surplus) then, in any such
case, the holder of this Warrant shall be entitled to receive,  upon exercise of
this  Warrant,  with  respect to each share of Common Stock  issuable  upon such
exercise, the amount of cash or evidences of indebtedness or other securities or
assets  which such holder  would have been  entitled to receive  with respect to
each such share of Common  Stock as a result of the  happening of such event had
this Warrant been exercised  immediately  prior to the record date or other date
fixing shareholders to be affected by such event.

         (d) If the  Company  shall at any time  consolidate  or merge  with any
other corporation or transfer all or substantially  all of its assets,  then the
Company shall deliver written notice to the Holder of such merger, consolidation
or sale of assets at least thirty (30) days prior to the closing of such merger,
consolidation  or sale of assets and this  Warrant  shall  terminate  and expire
immediately  prior  to the  closing  of such  merger,  consolidation  or sale of
assets.

         (e) As used in this Warrant,  the term 'Exercise  Price' shall mean the
purchase  price per share  specified in this Warrant until the  occurrence of an
event stated in subsection (b) of this Section 4 and thereafter  shall mean said
price as adjusted  from time to time in accordance  with the  provisions of said
subsection. No such adjustment shall be made unless such adjustment would change
the  Exercise  Price at the time by $.01 or more;  provided,  however,  that all
adjustments  not so made shall be deferred and made when the  aggregate  thereof
would change the Exercise Price at the time by $.01 or more. No adjustment  made
pursuant to any  provision of this Section 3 shall have the effect of




increasing  the total  consideration  payable  upon  exercise of this Warrant in
respect of all the Common Stock as to which this Warrant may be exercised.

         (f) In the event that at any time,  as a result of an  adjustment  made
pursuant to this Section 4, the holder of this Warrant  shall,  upon exercise of
this  Warrant,  become  entitled to receive  shares  and/or other  securities or
assets  (other than Common Stock) then,  wherever  appropriate,  all  references
herein to shares of Common  Stock shall be deemed to refer to and  include  such
shares and/or other  securities  or assets;  and  thereafter  the number of such
shares and/or other  securities  or assets shall be subject to  adjustment  from
time to time in a manner and upon terms as nearly  equivalent as  practicable to
the provisions of this Section 4.

         5.       Fractional Interests.

                  No fractional shares or scrip  representing  fractional shares
shall be issuable  upon the  exercise of this  Warrant,  but on exercise of this
Warrant,  the holder hereof may purchase only a whole number of shares of Common
Stock.  The  Company  shall make a payment in cash in respect of any  fractional
shares  which  might  otherwise  be  issuable  upon  exercise  of this  Warrant,
calculated by multiplying the fractional share amount by the Market Price of the
Company's Common Stock on the Date of Exercise.

         6.       Reservation of Shares.

                  The  Company  shall at all times  reserve  for  issuance  such
number of authorized  and unissued  shares of Common Stock (or other  securities
substituted  therefor  as herein  above  provided)  as shall be  sufficient  for
exercise of this Warrant. The Company covenants and agrees that upon exercise of
this Warrant,  all shares of Common Stock  issuable upon such exercise  shall be
duly and validly issued, fully paid, nonassessable and not subject to preemptive
rights of any shareholders..

         7.       Restrictions on Transfer.

                  This Warrant and the Common Stock issuable on exercise  hereof
have not been registered  under the Securities Act of 1933, as amended,  and may
not be sold, transferred,  pledged, hypothecated or otherwise disposed of in the
absence of  registration or the  availability of an exemption from  registration
under said Act and the Holder has furnished to the Company an opinion of counsel
reasonably  satisfactory to the Company to such effect, and any shares of Common
Stock issued upon exercise of this Warrant shall bear an  appropriate  legend to
that effect.  This Warrant may not be exercised,  and any shares of Common Stock
issuable  on exercise  hereof may not be  transferred  unless  such  exercise or
transfer would not result in a violation of the provisions of the Securities Act
of 1933, as amended.







         8.       Benefits of this Warrant.

                  Nothing in this Warrant  shall be construed to confer upon any
person  other  than the  Company  and the  holder of this  Warrant  any legal or
equitable  right,  remedy or claim under this Warrant and this Warrant  shall be
for the sole  and  exclusive  benefit  of the  Company  and the  holder  of this
Warrant.

         9.       Applicable Law.

                  This  Warrant is issued  under and shall for all  purposes  be
governed by and construed in accordance  with the laws of the State of Delaware,
without giving effect to conflicts of law.

         10.      Loss of Warrant.

                  Upon  receipt by the Company of  evidence of the loss,  theft,
destruction  or mutilation of this Warrant,  and (in the case of loss,  theft or
destruction)  of indemnity or security  reasonably  satisfactory to the Company,
and upon surrender and cancellation of this Warrant,  if mutilated,  the Company
shall execute and deliver a new Warrant of like tenor and date.

         11.      Notice to Company.

                  Notices or  demands  pursuant  to this  Warrant to be given or
made by the holder of this  Warrant to or on the Company  shall be  sufficiently
given or made if sent by certified or registered mail, return receipt requested,
postage prepaid or by overnight delivery (with personal delivery  acknowledged),
and addressed,  until another address is designated in writing by the Company to
Celgene Corporation, 7 Powder Horn Drive, Warren, NJ 07059 ; Attention: Chairman
of the Board and Chief Executive Officer.










         IN WITNESS WHEREOF, this Warrant is hereby executed effective as of the
date set forth below.


Dated as of:  August ___, 1995

                                                             CELGENE CORPORATION



                                           By:  ______________________________

                                           Print Name:  ________________________

                                           Its: _______________________________









                               SUBSCRIPTION FORM

TO:  CELGENE CORPORATION

         The  undersigned  hereby  irrevocably  exercises  the right to purchase
____________  shares of Common  Stock of CELGENE  CORPORATION  evidenced  by the
attached Warrant,  and herewith makes payment of the Exercise Price with respect
to such shares in full, all in accordance  with the conditions and provisions of
said Warrant.

         The  undersigned  agrees  not to offer,  sell,  transfer  or  otherwise
dispose of any of such Common Stock, except in accordance with the provisions of
Section 7 of the Warrant,  and consents that the following legend may be affixed
to the certificates  for the Common Stock hereby  subscribed for, if such legend
is applicable:

         'The  securities   represented  by  this   certificate  have  not  been
         registered under the Securities Act of 1933, as amended, and may not be
         sold,  transferred,  pledged,  hypothecated or otherwise disposed of in
         the absence of  registration  or the  availability of an exemption from
         registration under said Act.'

         The undersigned  requests that  certificates for such shares be issued,
and a warrant  representing any unexercised portion thereof be issued,  pursuant
to the Warrant in the name of and delivered to:



--------------------------------------------------------------------------------
                                      Name


--------------------------------------------------------------------------------
                                    Address


Dated:

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                         Signature of Registered Holder


--------------------------------------------------------------------------------
                       Name of Registered Holder (Print)


--------------------------------------------------------------------------------
                                    Address
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The attached  Warrant and the securities  issuable on exercise  thereof have not
been  registered  under  the  Securities Act of 1933, as amended, and may not be
sold, transferred, pledged, hypothecated or otherwise disposed of in the absence
of registration or the availability of an exemption from registration under said
Act.
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                                   ASSIGNMENT

                    (To be executed by the registered holder
                       desiring to transfer the Warrant)

FOR VALUE RECEIVED, the undersigned holder of the attached Warrant hereby sells,
assigns  and  transfers  unto the  person or  persons  below  named the right to
purchase ___________ shares of the Common Stock of CELGENE CORPORATION evidenced
by the  attached  Warrant and does  hereby  irrevocably  constitute  and appoint
_______________________  attorney to transfer  the said  Warrant on the books of
the Company, with full power of substitution in the premises.

Dated:                                            ______________________________
                                                  Signature

Fill in for new Registration of Warrant:

-----------------------------------------
                  Name


-----------------------------------------
                  Address


-----------------------------------------
Please print name and address of assignee
(including zip code number)


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NOTICE

The signature to the foregoing  Subscription  Form or Assignment must correspond
to the  name  as  written  upon  the  face  of the  attached  Warrant  in  every
particular, without alteration or enlargement or any change whatsoever.
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