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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

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                                    FORM 8-K

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                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                SEPTEMBER 16, 1996                                0-16132
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Date of Report (Date of earliest event reported)          Commission File Number

                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)

         DELAWARE                                        22-2711928
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(State or other jurisdiction of          (I.R.S. Employer Identification Number)
incorporation or organization)

                               7 POWDER HORN DRIVE
                            WARREN, NEW JERSEY 07059
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               (Address of Principal Executive Offices) (Zip Code)

                                 (908) 271-1001
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              (Registrant's telephone number, including area code)

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ITEM 5. OTHER EVENTS.

Adoption of Rights Plan

        On  September  16, 1996,  the Board of Directors of Celgene  Corporation
(the "Corporation") declared a dividend distribution of one right (a "Right") to
purchase one  one-tenth of a share of the Common Stock,  $.01 par value,  of the
Corporation (the "Common  Shares") for each  outstanding  share of Common Stock,
payable to the stockholders of record on September 26, 1996 (the "Record Date").
The Board of Directors  also  authorized  and directed the issuance of one Right
with respect to each Common Share issued  thereafter until the Distribution Date
(as defined  below).  Except as set forth  below,  each  Right,  when it becomes
exercisable, entitles the registered holder to purchase from the Corporation one
one-tenth  of a Common  Share at a price of $100.00 per whole  Common Share (the
"Purchase  Price"),  subject to  adjustment.  The  description  and terms of the
Rights are set forth in a Rights Agreement (the "Rights  Agreement") between the
Corporation  and American Stock  Transfer & Trust Company,  as Rights Agent (the
"Rights Agent"), dated as of September 16, 1996.

        Initially, the Rights will be attached to all certificates  representing
Common  Shares then  outstanding,  and no separate  Right  Certificates  will be
distributed.  Subject to certain  exceptions,  the Rights will separate from the
Common  Shares upon the earliest to occur of (i) a person or group of affiliated
or associated persons having acquired beneficial ownership of 15% or more of the
outstanding Common Shares (except pursuant to a Permitted Offer, as defined); or
(ii) 10  days  (or  such  later  date as the Board of  Directors  may determine)
following  the  commencement  or, announcement of an intention to make, a tender
offer or exchange  offer the  consummation  of which would result in a person or
group  of  affiliated  or  associated  persons  becoming an Acquiring Person (as
hereinafter   defined)  (the   earliest   of  such  dates   being   called   the
"Distribution  Date").  A person or group  whose  acquisition  of Common  Shares
causes a  Distribution  Date  pursuant  to  clause  (i)  above is an  "Acquiring
Person."  The date that a person or group  becomes  an  Acquiring  Person is the
"Shares  Acquisition  Date."   Notwithstanding  the  foregoing,   if  the  Board
determines in good faith that a person or group crossed the 15 percent threshold
inadvertently,  the rights will not be triggered if such person or group divests
as promptly as  practicable  a sufficient  number of Common Shares to reduce its
holding to below the 15 percent  threshold.  Furthermore,  a person who acquires
Common  Shares  pursuant  to a  tender  or  exchange  offer  which  is  for  all
outstanding  Common  Shares at a price and on terms which the Board of Directors
determines  (prior to  acquisition)  to be adequate and in the best interests of
the Corporation and its stockholders (other than such person, its affiliates and
associates) (a "Permitted  Offer") will not be deemed to be an Acquiring  Person
and such person's ownership will not constitute a Distribution Date.

        The Rights Agreement  provides that,  until the  Distribution  Date, the
Rights  will be  transferred  with and only with the  Common  Shares.  Until the
Distribution  Date (or earlier  redemption or expiration of the Rights),  Common
Share  certificates  issued  after  the  Record  Date upon the  transfer  or new
issuance  of Common  Shares  will  contain a notation  incorporating  the Rights
Agreement by reference.  Until the Distribution  Date (or earlier  redemption or
expiration of the Rights),  the surrender for transfer of any  certificates  for
Common Shares outstanding as of the Record Date, even without such notation or a
copy of this Summary of Rights being attached thereto,  will also constitute the
transfer of the Rights associated with the Common Shares
                                                          
                                                         

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represented  by  such  certificate.   As  soon  as  practicable   following  the
Distribution  Date,   separate   certificates   evidencing  the  Rights  ("Right
Certificates")  will be mailed to holders  of record of the Common  Shares as of
the close of  business  on the  Distribution  Date (and to each  initial  record
holder of certain Common Shares issued after the  Distribution  Date),  and such
separate Right Certificates alone will evidence the Rights.

        The Rights are not  exercisable  until the  Distribution  Date, and will
expire at the close of business on September 15, 2006,  unless earlier  redeemed
by the Corporation as described below.

        In the event that any person becomes an Acquiring Person, each holder of
Rights  (other  than  Rights  that have  become  void as  described  below) will
thereafter  have the right (the  "Flip-In  Right") to receive,  upon exercise of
such Rights,  the number of Common Shares (or, in certain  circumstances,  other
securities  of the  Corporation)  having  a  value  (immediately  prior  to such
triggering  event)  equal to two  times  the  aggregate  exercise  price of such
Rights.

        In the event that, at any time  following the Shares  Acquisition  Date,
(i) the  corporation  is  acquired  in a merger  or other  business  combination
transaction  in  which  the  holders  of all of the  outstanding  Common  Shares
immediately  prior to the consummation of the transaction are not the holders of
all of the surviving  corporation's  voting power,  or (ii) more than 50% of the
assets or earning power of the Corporation and its  majority-owned  subsidiaries
(taken as a whole) are sold or  transferred,  then each holder of Rights (except
Rights which  previously  have been voided as set forth above) shall  thereafter
have the right (the "Flip-Over Right") to receive, upon exercise of such Rights,
common  shares  of the  acquiring  party  having a value  equal to two times the
aggregate exercise price of the Rights;  provided,  however,  that the Flip-Over
Right  shall not apply to any  transaction  described  in clause (i) if (x) such
transaction  is with a person or persons (or a wholly  owned  subsidiary  of any
such person or persons)  that  acquired  Common  Shares  pursuant to a Permitted
offer and (y) the price and form of consideration offered in such transaction is
the  same as that  paid to all  holders  of  Common  Shares  whose  shares  were
purchased pursuant to the  Permitted  Offer. The holder of a Right will continue
to have the Flip-Over Right whether or not such holder  exercises or  surrenders
the Flip-In Right.

        Notwithstanding the foregoing,  following the occurrence of a triggering
event  described  above,  all Rights  that are or (under  certain  circumstances
specified in the Rights  Agreement)  were  beneficially  owned by any  Acquiring
Person or any affiliate or associate thereof will be null and void.

        The Purchase  Price  payable,  and the number of Common  Shares or other
securities issuable,  upon exercise of the Rights are subject to adjustment from
time to time to prevent  dilution (i) in the event of a stock  dividend on, or a
subdivision,  combination or  reclassification  of, the Common Shares, (ii) upon
the grant to holders of the Common Shares of certain options, rights or warrants
to subscribe  for or purchase  Common  Shares or  equivalent  securities  of the
Corporation  at a  price,  or  securities  convertible  into  Common  Shares  or
equivalent  securities of the Corporation with a conversion price, less than the
current market price of the Common  Shares,  or (iii) upon the  distribution  to
holders of the Common Shares of evidences of indebtedness  or assets  (excluding
regular quarterly cash dividends, if any) or of subscription  rights or warrants
(other than those referred to above).

                                                          
                                                         

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        With certain  exceptions,  no adjustment  in the Purchase  Price will be
required until  cumulative  adjustments  require an adjustment of at least 1% in
such Purchase  Price.  No  fractional  Common Shares will be issued and, in lieu
thereof, an adjustment in cash will be made based on the current market value of
a whole Right on the last trading day prior to the date of exercise.

        At any time prior to the  earlier to occur of (i) a person  becoming  an
Acquiring  Person or (ii) the  expiration  of the Rights,  the  Corporation  may
redeem  all but not less  than all of the  Rights  at a price of $ .01 per Right
(the  "Redemption  Price") which  redemption shall be effective at such time, on
such basis and with such  conditions  as the Board of Directors may establish in
its sole  discretion.  The  Corporation  may, at its option,  pay the Redemption
Price in Common Shares.

        All of the  Provisions  of the  Rights  Agreement  may be amended by the
Board  of  Directors  prior  to  the  Distribution  Date.  From  and  after  the
Distribution  Date, the provisions of the Rights Agreement may be amended by the
Board in order to cure any ambiguity,  defect or inconsistency,  to make changes
which do not adversely affect the interests of holders of Rights  (excluding the
interests  of any  Acquiring  Person),  or to  shorten or  lengthen,  subject to
certain limitations, any time period under the Rights Agreement.

        Until a Right is exercised,  the holder  thereof,  as such, will have no
rights as a stockholder of the Corporation,  including,  without limitation, the
right to vote or to receive dividends. While the distribution of the Rights will
not be taxable to stockholders of the Corporation,  stockholders may,  depending
upon the  circumstances,  recognize  taxable  income  should the  Rights  become
exercisable or upon the occurrence of certain events thereafter.

        The Rights have  certain  anti-takeover  effects.  The Rights will cause
substantial  dilution to a person or group that  attempts to acquire the Company
on terms not approved by the Board of Directors  except  pursuant to a Permitted
Offer.  The  Rights  should  not  interfere  with any  merger or other  business
combination approved by the Board of Directors, as the Rights may be redeemed by
the  Corporation  at $.01 per Right prior to the time that a person or group has
acquired beneficial ownership of 15% or more of the Common Shares.

        The Rights  Agreement,  dated as of  September  16,  1996,  between  the
Corporation  and  American  Stock  Transfer & Trust  Company,  as Rights  Agent,
specifying  the terms of the  Rights is  attached  hereto as an  exhibit  and is
incorporated  herein by  reference.  The  foregoing  description  of the  Rights
Agreement is qualified in its entirety by reference to such exhibit.

Amendments to Bylaws

        In addition,  the Board of Directors of the Company has adopted  certain
amendments to the Company's  Bylaws intended to strengthen the Board's  position
in the event of a hostile  takeover  attempt.  The amendments to the Bylaws have
the following effects:

        1. Providing that (i) only persons who are nominated in accordance  with
the  procedures  set forth in the  Bylaws  shall be  eligible  for  election  as
directors of the Corporation, except as may be otherwise provided in the Bylaws,
and that (i) only  business  brought  before the
                                                          
                                                         

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annual  meeting by the Board of Directors or by a stockholder  who complies with
the procedures set forth in the Bylaws may be transacted at an annual meeting of
stockholders. In addition to any other applicable requirements, for a nomination
to be made by a  stockholder,  or proposals of new business to be  transacted at
the annual meeting to be made by a stockholder, such stockholder must have given
timely  notice   thereof  in  proper  written  form  to  the  Secretary  of  the
Corporation. For notice of nominations of directors or proposals of new business
at stockholder  meetings to be timely,  a stockholder's  notice to the Secretary
must be delivered to or mailed and received at the principal  executive  offices
of the  Corporation not less than sixty (60) days nor more than ninety (90) days
prior to the date of the annual meeting;  provided,  however,  that in the event
that less than seventy (70) days' notice or prior public  disclosure of the date
of  the  annual  meeting  is  given  or  made  to  stockholders,  notice  by the
stockholder (in order to be timely) must be so received not later than the close
of business on the tenth  (10th) day  following  the day on which such notice of
the date of the annual meeting was mailed or such public  disclosure of the date
of the annual meeting was made,  whichever first occurs. To be in proper written
form,  a  stockholder's  notice to the  Secretary  must set forth (a) as to each
person whom the stockholder  proposes to nominate for election as a director (i)
the name, age,  business address and residence  address of the person,  (ii) the
principal  occupation or employment of the person, (iii) the class or series and
number  of  shares  of  capital  stock  of  the  Corporation   which  are  owned
beneficially or of record by the person and (iv) any other information  relating
to the person that would be required to be  disclosed  in a proxy  statement  or
other filing required to be made in connection with solicitations of proxies for
election of directors  pursuant to Section 14 of the Securities  Exchange Act of
1934, as amended (the "Exchange Act"), and the rules and regulations promulgated
thereunder;  and (b) as to the  stockholder  giving  the notice (i) the name and
record  address  of such  stockholder,  (ii) the class or series  and  number of
shares of capital stock of the  Corporation  which are owned  beneficially or of
record  by  such  stockholder,  (iii)  a  description  of  all  arrangements  or
understandings  between such stockholder and each proposed nominee and any other
person or persons  (including  their names) pursuant to which the  nomination(s)
are to be made by such stockholder,  (iv) a representation that such stockholder
intends to appear in person or by proxy at the annual  meeting to  nominate  the
persons  named in his  notice  and (v) any other  information  relating  to such
stockholder that would be required to be disclosed in a proxy statement or other
filing  required  to be made in  connection  with  solicitations  of proxies for
election of  directors  pursuant to Section 14 of the Exchange Act and the rules
and  regulations  promulgated  thereunder.  Such notice must be accompanied by a
written  consent of each  proposed  nominee to being  named as a nominee  and to
serve as a director if elected.

        2. Eliminating the ability of persons other than members of the Board of
Directors to call special meetings of the stockholders of the Company.

        3. Establishing a procedure for the Board of Directors to fix the record
date whenever stockholder action by written consent is undertaken. The provision
of the Bylaws  provides  that in order that the  Corporation  may  determine the
stockholders  entitled  to consent  to  corporate  action in  writing  without a
meeting,  the Board of Directors may fix a record date,  which record date shall
not precede the date upon which the resolution fixing the record date is adopted
by the Board of  Directors,  and which date shall not be more than ten (10) days
after the date upon which the  resolution  fixing the record  date is adopted by
the  Board  of  Directors.  Any  stockholder  of  record  seeking  to  have  the
stockholders  authorize or take corporate  action by

                                                          
                                                         

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written consent shall, by written notice to the Secretary,  request the Board of
Directors to fix a record date. The Board of Directors  shall  promptly,  but in
all  events  within  ten (10)  days  after the date on which  such a request  is
received,  adopt a resolution fixing the record date. If no record date has been
fixed by the Board of Directors within ten (10) days of the date on which such a
request is received,  the record date for determining  stockholders  entitled to
consent to corporate  action in writing without a meeting,  when no prior action
by the Board of Directors is required by applicable law, shall be the first date
on which a signed written  consent setting forth the action taken or proposed to
be taken is delivered to the Corporation by delivery to its registered office in
the State of Delaware, its principal place of business or an officer or agent of
the Corporation  having custody of the book in which  proceedings of meetings of
stockholders are recorded, to the attention of the Secretary of the Corporation.
This  provision  of the  Bylaws  also  provides  for a  procedure  by which  the
Secretary of the Corporation  shall conduct such reasonable  investigation as he
deems necessary or appropriate  for the purpose of ascertaining  the validity of
written consents submitted by stockholders and all matters incident thereto.

        4. Requiring a 2/3 vote of  stockholders  to amend Sections 1.2, 1.8 and
2.2 of the Company's Bylaws.

        The Company's  Bylaws,  as amended and restated as of September 16, 1996
are attached hereto as an exhibit and are incorporated herein by reference.  The
foregoing description of the Bylaws is qualified in its entirety by reference to
such exhibit.


ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS.

        (c)    Exhibits.

               1.   Rights  Agreement,  dated as of September 16, 1996,  between
                    Celgene  Corporation  and  American  Stock  Transfer & Trust
                    Company   (incorporated   by   reference  to  the  Company's
                    Registration  Statement on Form  8-A, filed on September 16,
                    1996.

               2.   Celgene  Corporation  Bylaws,  as amended and restated as of
                    September 16, 1996.

                                                          
                                                         

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                                   SIGNATURES

        Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

Date: September 16, 1996            CELGENE CORPORATION

                                    By:   /s/ John W. Jackson
                                       --------------------------
                                    Name:   John W. Jackson
                                    Title: Chairman of the Board and
                                              Chief Executive Officer

                                                          
                                                         

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                                  EXHIBIT INDEX



Exhibit        Description                                                          Page
                                                                              
1.   Rights  Agreement,   dated  as  of  September  16,  1996,  between  Celgene
     Corporation  and American Stock Transfer & Trust Company  (incorporated  by
     reference to the  Company's  Registration  Statement on Form 8-A,  filed on
     September 16, 1996).

2.   Celgene  Corporation  Bylaws,  as amended and restated as of September  16,
     1996.


                                                          
                                                         

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