EXHIBIT 8.3










                                 [Letterhead of]
                                Ernst & Young LLP


September 11, 1996


Board of Directors                          Board of Directors
Axion Inc. and Axion HealthCare Inc.        Bristol-Myers Squibb Company
1111 Bayhill Drive, Suite 125               345 Park Avenue
San Bruno, California  94066                New York, New York  10154


Dear Board Members:

This  letter  sets  forth our  opinion  concerning  certain  Federal  income tax
consequences  that  would  arise  from the pro rata  distribution  by Axion Inc.
("Distributing")  to its  shareholders  of the  stock of Axion  HealthCare  Inc.
("Controlled"),  followed by the  acquisition  of the stock of  Distributing  by
Bristol-Myers  Squibb  Company  ("Acquiring")  solely in exchange for  Acquiring
stock (the "Acquisition").  Such transactions, along with the other transactions
described herein, are hereinafter referred to as the "Proposed Transaction."

In rendering this opinion,  we have relied upon the facts,  summarized below, as
they have  been  presented  to us orally  and in the  following  documents  (the
"Documents"):

1.      The  representation  letter  provided by the managements of Distributing
        and Controlled dated August 2, 1996, attached hereto as Exhibit A.

2.      The representation letter provided by the management of Acquiring, dated
        August 2, 1996, attached hereto as Exhibit B.

3.      The  Agreement  and Plan of Merger  dated as of  August  2,  1996  among
        Acquiring,  OTNC  Acquisition  Sub Inc., and  Distributing  (the "Merger
        Agreement")  and the  agreements  set forth in Section 3.01 thereof (the
        "Ancillary Agreements").

4.      The Joint Proxy  Statement/Prospectus and the Required AHC Documents, as
        defined in












 






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         Section 4.01(d)(ii) of the Merger Agreement.

5.      The Form S-4  Registration  Statement  under the  Securities Act of 1933
        filed by Acquiring in connection  with the  transaction  contemplated by
        the Merger Agreement (the "Form S-4").

6.      Internal   Revenue    Service   Revenue    Procedure   96-30   Checklist
        Questionnaire.



7.      Representation   letters   received   from   various   shareholders   of
        Distributing in the form attached hereto as Exhibit C (relating to their
        intention  with  respect  to the  holding  of  stock of  Controlled  and
        Acquiring.)

You have advised us that the facts contained in the Documents,  and as set forth
below,   provide  an  accurate  and  complete   description  of  the  facts  and
circumstances concerning the proposed transactions.  We have made no independent
determination regarding such facts and circumstances and, therefore, have relied
upon the Documents  for purposes of this letter.  Any changes to the facts or to
the Documents may affect the  conclusions  stated herein,  perhaps in an adverse
manner.

We  understand  that you will  include  references  to Ernst & Young LLP and our
opinion  in the Form S-4 and will  include a copy of our  opinion  as an exhibit
thereto.  Subject to our prior review and approval,  we consent to the inclusion
of such references and a copy of our opinion.



                               STATEMENT OF FACTS

Axion Inc.  ("Distributing")  was  incorporated  under  Delaware law in 1987, as
Access  Biotechnology,  Inc.,  and  changed  its name to Axion in 1994.  Through
subsidiaries,  Distributing  is engaged in the  Clinical/Disease  Management and
Distribution Businesses, described more fully below.

The Clinical/Disease Management Business












 






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The   Clinical/Disease   Management   Business  is  a   collection   of  related
cancer-focused  healthcare  activities  designed  to  promote  provision  of the
highest quality  cost-effective  cancer care by office-based  oncologists.  This
business began upon  Distributing's  incorporation  in 1987 through its clinical
studies  activity.  This activity,  which continues to the present,  consists of
coordinating  the study of emerging  cancer  drugs and  treatments  developed by
pharmaceutical  and  biotechnology  companies.  A  significant  contribution  of
Distributing  in this area is its ability,  through its  relationships  with the
Southwest  Oncology Group and others, to facilitate these studies on patients in
doctor's  offices.  Depending  on the  particular  item,  the company  will help
develop the  parameters of the study,  negotiate  the  contract,  act as project
manager, provide logistical support (such as ordering,  receiving,  tracking and
disbursing drug shipments, and tracking patient sign-ups and responses), receive
and disburse payments, collect and analyze the data, and prepare a report of the
results.  The drug utilization  data developed is likely the most  comprehensive
available  in the  industry.  Revenues  are  derived  from  contracts  with drug
companies and practice groups.

The information and  relationships  developed in the clinical  studies  activity
have  resulted  in the  provision  of other  services,  largely to  office-based
oncologists,  including  reimbursement  assistance,  preparation of Federal Drug
Administration  applications,  practice  management,  and  (through  OPUS Health
Systems,  described below),  inventory management.  Moreover,  its knowledge and
experience  have  enabled  the  company to develop  cancer  drug  protocols  and
treatment  guidelines  which serve as integral  parts of its disease  management
program. In this activity,  began in 1993, the company negotiates with payers to
manage the delivery of cancer care. In this regard,  the company has developed a
network of physicians  through  which such care is provided  using the protocols
and guidelines  described above, and the computer resources described below, all
with a view to providing the highest quality, cost-effective cancer treatment.


At the  end  of  1994,  the  assets  and  liabilities  of  the  Clinical/Disease
Management Business were contributed to a newly-formed  wholly-owned subsidiary,
formerly   OnCare  Health  Inc.   (presently   named  Axion   HealthCare   Inc.)
("Controlled"), which conducts all of the foregoing activities.

The Distribution Business

In September 1990, Distributing began to distribute oncology pharmaceuticals and
related












 






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supplies to office-based oncology practices (the "Distribution  Business").  The
Distribution  Business provides these practices with next-day delivery (compared
with days or weeks when the drugs are ordered  from the  manufacturer),  thereby
reducing inventory requirements and pharmaceutical expiration.

Distributing  directly  conducted both the  Clinical/Disease  Management and the
Distribution  Businesses until 1993. In July 1993,  Distributing  entered into a
series of agreements with Bristol-Myers Squibb Company ("Acquiring") to form the
Oncology   Therapeutics   Network  Joint  Venture,   L.P.,  a  Delaware  limited
partnership ("OTNJV").  Distributing formed a wholly-owned subsidiary,  Oncology
Therapeutics  Network  Corporation  ("OTNC"),  to act as the general  partner of
OTNJV. A wholly-owned subsidiary of Acquiring ("BMS Partner Sub") is the limited
partner.  Distributing  contributed the assets of its  Distribution  Business to
OTNC,  which,  in  turn,   contributed  those  assets  to  OTNJV.  In  addition,
Distributing  agreed  to  provide  all  administrative,  operational,  and other
services  necessary to support the joint venture,  subject to reimbursement  for
its costs by OTNJV.  Acquiring  appointed OTNJV as its exclusive sales agent for
Acquiring's oncology products for office-based practices.

In addition to the  Clinical/Disease  Management  and  Distribution  Businesses,
Distributing   conducts  an  Information   Management  Business  and  previously
conducted a Physicians Practice Management Business.

The Information Management Business

The Information  Management  Business,  which provides inventory and information
management  systems to oncology  practices,  is  conducted  through  OPUS Health
Systems,  Inc. formerly OnCare Systems Inc. ("OPUS"), a wholly-owned  subsidiary
of Distributing.  OPUS provides oncologists with state-of-the-art  technology in
inventory  management  and drug  utilization.  The  information  provided by the
Information  Management  Business allows oncologists to use the most appropriate
pharmaceuticals  (including  generics),  and  then  only  when  needed,  thereby
reducing inventory carrying costs.

Included in OPUS' Information  Management  Business is the OPUS Station activity
("OPUS  Station").  OPUS Station is an automated  drug  dispensing and inventory
tracking  activity,  specifically  tailored for use in the  outpatient  setting.
Located in the doctor's office, the OPUS












 






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Station equipment links the local oncology practice with OTNJV.

OPUS also owns and operates the OPUS Matrix, a Windows-based  application,  that
generates  recommended treatment procedures from patient diagnoses and treatment
regimens.  As part of the disease  management  activity,  OPUS  Matrix  provides
office-based  oncology  practices with access to a central  database  containing
drug and treatment information.

The Physician Practice Business

OnCare Inc., previously a more-than-80-percent-owned subsidiary of Distributing,
is an  oncology-specific  physician practice management company,  which acquires
and manages local oncology practices (the "Physician  Practice  Business").  The
oncologists  who  were the  former  owners  of the  acquired  practices  work as
professional  service  providers to the company.  OnCare Inc.'s  providers  (who
employ the OnCare  treatment  guidelines in their  practice) are  represented to
health  plans as part of a select  managed  cancer care  network  that can offer
documented proof of  high-quality,  cost-effective  care. All of  Distributing's
common stock of OnCare Inc. was distributed to its  shareholders on December 31,
1995.

As of June 30, 1996,  Distributing  had one class of common  stock,  and several
classes of  preferred  stock,  issued  and  outstanding.  Distributing  also has
outstanding  certain  warrants and  employee  options with respect to its common
stock.  The common  stock  consists of 15 million  authorized  shares,  of which
approximately  1.6 million are issued and outstanding.  Preferred stock consists
of 10 million authorized  shares, of which  approximately 6.7 million are issued
and  outstanding.  The preferred stock is divided into Classes A - F; each class
is  convertible  into common stock.  No dividends are in arrears on any class of
preferred  stock.  Distributing  also has  outstanding  certain  employee  stock
options.

Distributing  uses the  accrual  method of  accounting  for  Federal  income tax
purposes and files its consolidated Federal income tax return on a calendar year
basis.


                                BUSINESS PURPOSE

The Acquisition is being  undertaken to secure a number of strategic  objectives
for Distributing












 






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and  Acquiring,  including  (a)  elimination  of a  conflict  perceived  by  the
customers  of  the   Distribution   Business   between  that  business  and  the
clinical/disease   management  and  physician  practice   activities;   (b)  the
opportunity  to  increase  sales to  office-based  oncology  practices;  and (c)
allowing Acquiring to expand the quality of services provided to such practices.

Distributing   must  separate  the  Distribution   Business  from  the  rest  of
Distributing's activities in order to permit the Acquisition to occur. Acquiring
has stated that it has no interest in  acquiring  from  Distributing  any assets
other  than (i) 100  percent  of OTNC's  interest  in  OTNJV,  and (ii) the OPUS
Station   activities   (collectively   referred  to  as  the  "Wanted  Assets").
Accordingly,  as a condition to the  acquisition  of the stock of  Distributing,
Acquiring will require that Distributing divest all assets and liabilities other
than  the  Wanted  Assets  (and  related   liabilities)   prior  to  Acquiring's
acquisition of that stock. Further, separation of the Distribution Business from
its other  activities  is integral to  Distributing's  decision to undertake the
Acquisition.


                              PROPOSED TRANSACTION

The following transactions have been proposed for the business reasons described
above.

      1.   OTNJV will distribute to OTNC, cash representing a preference payment
           to which OTNC is entitled for periods ending June 30, 1996. OTNC will
           distribute that cash to Distributing.

      2.   OPUS will  transfer to a newly  created  corporation,  OPUS Sub,  the
           assets related to the OPUS Matrix activity.  OPUS Sub will assume all
           related liabilities.

      3.   OPUS will distribute the stock of OPUS Sub to Distributing.

      4.   Distributing  will contribute to Controlled all assets other than the
           Wanted  Assets.  Controlled  will assume all  liabilities  other than
           those  related to the Wanted Assets and those  previously  assumed by
           OPUS Sub.

      5.   Previously  nonvested  Distributing  options will become vested.  All
           options  will be exercised or  cancelled.  Distributing  will provide
           loans to facilitate exercise.












 






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                                                              September 11, 1996







      6.   Controlled will be recapitalized through the exchange by Distributing
           of all of its  shares  of  Controlled  common  stock  for a number of
           shares of Controlled preferred stock equal to the number of shares of
           Distributing stock outstanding.

      7.   Distributing  will  distribute  all of the stock of Controlled to its
           shareholders on a pro rata basis.  (In order for the  distribution to
           be pro rata,  and to put the  Distributing  shareholders  in the same
           position  as if  Step  8  below  had  already  occurred,  holders  of
           Distributing  preferred  stock will waive  dividend  preferences  (if
           any)).

      8.   All of  Distributing's  preferred stock will be converted into common
           stock by vote of the preferred shareholders.

      9.   Acquiring  will cause a newly formed  wholly-owned  subsidiary,  OTNC
           Acquisition  Sub Inc.,  to merge into  Distributing.  In the  merger,
           Distributing's shareholders will receive solely stock of Acquiring in
           exchange for their  Distributing  stock. Cash will be paid in lieu of
           fractional shares.


                            MEMORANDUM OF AUTHORITIES

THE DISTRIBUTION OF CONTROLLED STOCK

Section  368(a)(1)(D)  of the  Internal  Revenue  Code of 1986,  as amended (the
"Code")  provides  in  part  that a  reorganization  includes  a  transfer  by a
corporation of part of its assets to another  corporation if,  immediately after
the transfer,  the  shareholders  of the transferor are in "control" (as defined
below) of the transferee,  and, pursuant to the plan, stock or securities of the
transferee are distributed in a transaction which qualifies under Section 355 of
the Code.












 






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Section 355 provides for the tax free  distribution of the stock of a controlled
subsidiary. In general, to meet the requirements of Section 355 --

(i)   Immediately  before the  distribution,  the distributing  corporation must
      "control" the  corporation  whose shares are being  distributed.  The term
      "control" is defined by Section  368(c) to mean stock  possessing at least
      80 percent of the total  combined  voting power and at least 80 percent of
      the  total  number  of shares  of all  other  classes  of  stock.  Section
      355(a)(1)(A);

(ii)  Immediately after the  distribution,  both the distributing and controlled
      corporations must be engaged in the active conduct of a trade or business.
      Section  355(a)(1)(C)  and (b). This active conduct of a trade or business
      requirement  is  satisfied  only if the  trade or  business  was  actively
      conducted   throughout  the  five-year   period  ending  on  the  date  of
      distribution,  and that business (or control of a  corporation  conducting
      that  business) was not acquired  within that period in a  transaction  in
      which gain or loss was recognized. Section 355(b)(2);

(iii) The  distributing  corporation  must  distribute  all  of  its  stock  and
      securities in the  controlled  corporation  or distribute  enough stock to
      constitute  control and establish to the satisfaction of the Treasury that
      the retention of stock in the controlled  corporation is not part of a tax
      avoidance plan. Section 355(a)(1)(D);

(iv)  The  transaction  must  not  be  used  principally  as a  device  for  the
      distribution of earnings and profits. Section 355(a)(1)(B);

(v)   There must be a  corporate  business  purpose  for the  transaction  and a
      continuity  of  interest.  Section  1.355-2(b)  and (c) of the  Income Tax
      Regulations (the "Regulations"); and

(vi)  The  transaction  must not  constitute a  "disqualified  distribution"  as
      defined in Section 355(d)(2) of the Code.


Control Immediately Before the Distribution













 






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With regard to the Section 355 requirements  above, the test described in (i) is
satisfied  because  Distributing will own 100 percent of the stock of Controlled
immediately before the distribution.












 






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Active Conduct of a Trade or Business

The  active  trade  or  business  requirement  of  Section  355(b)  has  several
components:  (i) the distributing and controlled corporations must be engaged in
the active conduct of a trade or business  immediately  after the  distribution;
(ii) the business(es) must have been actively conducted for the five-year period
before the distribution;  and (iii) neither the active business nor the stock of
the  controlled  corporation  may have been  acquired  in a taxable  transaction
during the five-year period preceding the distribution.  Sections  355(b)(1) and
(2).

The five-year  active  business  requirement is satisfied if the businesses have
been actively conducted by the distributing or controlled  corporations for five
years before the distribution.  Corporations are considered  actively engaged in
the  conduct  of a trade  or  business  if they  carry  on a  specific  group of
activities,  generally  including the  collection of income,  for the purpose of
earning a profit and the payment of expenses.  Section  1.355-3(b)(2)(ii) of the
Regulations.  A corporation is engaged in the active conduct of a trade business
if it is directly so engaged, or if "substantially all" of its assets consist of
stock of one or more corporations which are so engaged. Section 355(b)(2)(A).  A
corporation will meet this  "substantially all" requirement if 90 percent of the
fair  market  value  of  its  gross  assets  consists  of  stock  of  qualifying
corporations. Rev. Proc. 77-37, 1977-2 C.B. 568.

Generally,  a trade or business is  considered  to be actively  conducted if the
corporation  itself performs  active and substantial  management and operational
functions.  Although  activities  performed  on  behalf  of the  corporation  by
independent  contractors  and other  parties  outside  the  corporation  are not
considered as performed by the corporation,  the active conduct  requirement may
be  satisfied  even though some  activities  are  performed  by others.  Section
1.355-3(b)(2)(iii) of the Regulations.

Distributing  has  been  directly  engaged  in the  Clinical/Disease  Management
Business  from 1987 to 1994,  and  indirectly  engaged  in the  Clinical/Disease
Management Business through its wholly-owned  subsidiary Controlled from 1995 to
the present.  The activities of Controlled  that relate to the  Clinical/Disease
Management  Business  include the full process of earning  income or profit,  as
described in Section 1.355-3(b)(2)(ii) of the Regulations.

In this regard, we note that the disease  management  activity began in 1993. It
is unclear












 






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whether this activity is a part of a single business,  or is a separate business
activity. Section 1.355-3(b)(3)(ii) of the Regulations provides that:

        "[I]f a  corporation  engaged  in the  active  conduct  of one  trade or
        business during that five-year period purchased,  created,  or otherwise
        acquired  another  trade or business in the same line of business,  then
        the  acquisition  of that other  business  is  ordinarily  treated as an
        expansion  of the original  business,  all of which is treated as having
        been  actively  conducted  during  that  five-year  period,  unless that
        purchase,  creation,  or other  acquisition  effects  a change of such a
        character  as  to  constitute  the  acquisition  of a new  or  different
        business."

As explained supra, in light of the fact that the disease management  activities
evolved out of, and use the information  developed by, the  corporation's  other
cancer focused healthcare activities, an argument can be made that these are all
part of single  business  activity.  Even if,  however,  the disease  management
activity  is viewed  to be a  separate  business,  Controlled  will  nonetheless
satisfy the 5-year active business test by virtue of its remaining activities.

In addition,  the proposed transactions  contemplate that Controlled will have a
substantial  amount of cash and similar  assets.  Assuming  arguendo  that these
assets are not viewed as active  business assets (see below),  nonetheless,  the
Internal  Revenue  Service (the  "Service") has held that a corporation may meet
the  active  business  test  even  though a small  percentage  of its  assets is
directly utilized in the active business activity.  See Rev. Rul. 73-44,  1973-1
C.B. 182; GCM 34238 (where the active business assets amount to 5 percent of the
total  assets).(1)  See  also,  TAM  8308007  (October  29, 1982).  Instead,  as
described more fully below,  the  existence of cash has been  analyzed under the
"device" rules.

In this regard,  it should be noted that, on August 8, 1996,  the Service issued
Rev. Proc.  96-43,  1996-35 I.R.B. 6, amplifying Rev. Proc. 96-3, 1996-1 IRB 82.
Rev. Proc. 96-43 provides that

- --------
(1) Pursuant  to  Section  6110(j)(3)  of  the  Code,  private  letter  rulings,
technical  advice  memorandums,  and  GCMs are not  cited as  precedent,  but to
illustrate a consistent position by the Service.













 






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the Service will  ordinarily  not issue an advance  ruling  regarding  whether a
distribution  qualifies  under  Section 355 when the gross value of the trade or
business relied on to satisfy the active business  requirement is less than five
percent of the gross  value of all of the assets of the  corporation.  We do not
believe that the issuance of Rev. Proc. 96-43 changes the conclusions  expressed
herein.

Distributing has been directly engaged in the Distribution Business from 1990 to
1993,  and  indirectly  engaged in the  Distribution  Business  from 1993 to the
present  through  its  wholly-owned  subsidiary  OTNC  (which  owns a 50 percent
general partnership interest in OTNJV). The conduct of the Distribution Business
includes the full process of earning  income or profit,  as described in Section
1.355-3(b)(2)(ii) of the Regulations.

We  believe  that the  formation  of OTNJV and the  transfer  of assets to it in
1993 does not  cause  the   Distribution   Business   previously   conducted  by
Distributing to fail to satisfy the 5-year active business test. In this regard,
we note  that OTNC  actively  manages  the  operations  of  OTNJV.  Accordingly,
applicable  authorities  indicate  that  it is  still  actively  engaged  in the
Distribution Business begun by Distributing.

In Rev. Rul. 79-394, 1979-2 C.B. 141, amplified by Rev. Rul. 80-181, 1980-2 C.B.
121, the Service concluded that operational  activities  relating to corporation
X, that were conducted by another member of the affiliated  group of which X was
a member,  could be taken together with the management  activities  conducted by
the officers of X to satisfy the active trade or business requirement of Section
355.  Similarly,  in Rev. Rul.  92-17,  1992-1 C.B.  142, a limited  partnership
("LP")  owned  certain  real estate that it  operated  for more than 5 years.  D
corporation  had been a 20 percent  general partner in LP for more than 5 years.
D's officers  performed  active and  substantial  management  functions  for the
business  conducted by LP,  including  supervising  LP's employees.  The Service
concluded  that  management   activities  conducted  by  D  in  support  of  the
operational  activities  conducted by LP satisfied  the active trade or business
requirements  of Section 355. See also, PLR 9510005  (December 5, 1994) in which
the Service  applied Rev. Rul. 92-17 and found that a corporation met the active
trade or  business  requirement  of Section 355 where that  corporation  was the
managing general partner of a partnership that conducted a business meeting that
requirement.  Furthermore,  we understand that the day-to-day  operations of the
Distribution Business changed very little (if at all) after the formation of the
partnership, and are now conducted largely by employees of OTNC.












 






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Accordingly,  we believe that  Distributing  (through  OTNC) should be viewed as
continuing its Distribution Business.

Thus, for the foregoing reasons,  while not free from doubt, we believe that the
active trade or business requirement for both Distributing and Controlled should
be satisfied in this case.

Distribution of Control

The requirement in (iii) will be satisfied in the proposed  transaction  because
Distributing  will  distribute  100  percent of the stock of  Controlled  to its
shareholders in the distribution.

Device to Distribute Earnings and Profits

As  noted,  Section  355(a)(1)(B)  of the Code  and  Section  1.355-2(d)  of the
Regulations  provide  that  Section  355 does not  apply to a  transaction  used
principally as a device for the  distribution of the earnings and profits of the
distributing corporation,  the controlled corporation,  or both. The Regulations
provide that,  generally,  the  determination  of whether a transaction was used
principally  as a device  will be made from all of the facts and  circumstances,
including,  but not  limited  to, the  presence  or  absence of certain  factors
described therein. Section 1.355-2(d) of the Regulations.

Section  1.355-2(d)(2)(iii)  of the Regulations provides that a sale or exchange
of the stock of the  distributing  or  controlled  corporation  is evidence of a
device. Section  1.355-2(d)(2)(iii)(E)  further provides, however, that if stock
is exchanged for stock in pursuance of a plan of reorganization in which no gain
or loss (or an insubstantial amount of gain) is recognized,  the exchange is not
treated as evidence of device, and the device rules will be applied by reference
to the  stock  received.  In the  present  case,  the  exchange  of the stock of
Distributing  after the  spin-off  will be effected  pursuant  to a  transaction
qualifying as a tax-free reorganization described in Section 368(a)(1)(B) of the
Code.  Accordingly,  such  exchange  will not  result in the  transaction  being
considered  to have been used  principally  as a  device.  Further,  it has been
represented that certain shareholders of Distributing have no plan or intention,
and the management of Distributing  knows of no plan or intention on the part of
the remaining Distributing shareholders, to sell or exchange stock of Controlled
or Acquiring after the Acquisition.












 






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In general,  Section  1.355-2(d)(2)(iv)(B)  of the Regulations provides that the
existence of assets not used in a trade or business  (including  cash and liquid
assets not related to the reasonable needs of the business) is evidence that the
transaction  is being used  principally  as a device to distribute  earnings and
profits.   The  strength  of  this  evidence   depends  on  all  the  facts  and
circumstances,  including the ratio for each  corporation of the value of assets
not used in a trade or business  to the value of assets that  satisfy the active
trade or business  requirement of Section 355. Section  1.355-2(d)(3)(ii) of the
Regulations  provides that the existence of a corporate business purpose for the
transfer or retention of assets not used in a trade or business can outweigh the
evidence of device presented by such transfer or retention.

In the  present  case,  cash and other  liquid  assets  will be  transferred  by
Distributing   to  Controlled  as  part  of  the   transaction.   Management  of
Distributing  has indicated that the disease  management  activity of Controlled
(which, as noted, evolved from the clinical operations) will require substantial
funds beyond expected operating profits to maintain and expand its data base and
to market its services throughout the oncology community.  We further understand
that,  because these  activities are in their initial  stages,  it would be very
difficult for  Controlled  to obtain  lending from outside  sources.  Similarly,
management of  Distributing  and Controlled have  represented  that the cash and
other  liquid  assets will only be used in the business  activities  retained by
Controlled or to satisfy  obligations under agreements  relating to the Proposed
Transaction.  Further,  we  understand  that  Acquiring and  Distributing  never
considered that these assets would be retained in the  Distribution  Business or
otherwise included in the Acquisition.  Therefore,  arguably, the cash and other
liquid assets are related to the reasonable needs of Controlled's  business;  in
any event, there is a business purpose for the transfer.

The  Service  has ruled that a  contribution  to a  controlled  corporation,  in
anticipation of a spin-off,  made to allow the controlled  corporation to expand
its business,  is not indicative that the  transaction is used  principally as a
device to distribute earnings and profits.  In Rev. Rul. 83-114, 1983-2 C.B. 66,
immediately  prior  to  the  spin-off,  the  distributing  corporation  canceled
indebtedness  owed by a controlled  corporation in order to enable the latter to
expand  its  business  with  operating  proceeds  and  investment  capital.  The
cancellation  resulted in more  than a  100-percent  increase in the  controlled
corporation's  net worth.  Rev.  Rul.  83-114  concluded  that,  in light of the
business purpose for the contribution, the distribution was not used principally
as a device to distribute earnings and profits.













 






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                                                              September 11, 1996






In  addition,  the  Service  has held that a  transfer  of cash to a  controlled
corporation  made to  equalize  values in a  split-off  transaction  will not be
considered  as evidence  that the  transaction  is being used  principally  as a
device for the  distribution  of earnings and  profits.  See Rev.  Rul.  64-102,
1964-1  C.B.  136  (capital  contribution  more  than  doubled  the value of the
controlled   corporation);   Rev.  Rul.   71-383,   1971-2  C.B.  180;   Section
1.355-2(d)(3)(iv)(B) of the Regulations. Compare Rev. Rul. 86-4, 1986-1 C.B. 174
(transfer of investment  assets by  distributing  to the controlled  corporation
immediately  prior to a pro-rata  spin-off was a factor to be considered,  along
with other factors,  in determining  whether the transaction was a device);  cf.
Rev. Rul. 59-400, 1959-2 C.B. 114, (shift in earnings from a hotel business to a
rental real estate business  approximately one year prior to a pro rata spin-off
resulted in nonqualification  under Section 355 in light of the fact that rental
real estate was involved).

Accordingly, based on the facts and circumstances,  cash and other liquid assets
can be contributed to a controlled corporation in anticipation of a distribution
without the  transaction  being  considered to have been used  principally  as a
device to distribute  earnings and profits.  The instant  transaction appears to
present such a case. Thus, in this case,  there is an important  business reason
for the  distribution  of the  stock of  Controlled,  i.e.,  to  facilitate  the
acquisition  by  Acquiring.  Further,  as stated  above,  there is an  important
business reason for the contribution of cash and similar  assets--i.e.,  to fund
the continued  development and expansion of the disease  management  activities.
Moreover,  these assets are not to be included in the Acquisition.  Accordingly,
while not free  from  doubt,  we  believe  that the  transaction  should  not be
considered to have been used  principally  as a device for the  distribution  of
earnings and profits.

Business Purpose

Section  1.355-2(b)  of the  Regulations  provides that Section 355 applies to a
transaction  only  if it is  carried  out for  one or  more  corporate  business
purposes. A transaction is carried out for a corporate business purpose if it is
motivated,  in whole or  substantial  part,  by one or more  corporate  business
purposes. A corporate business purpose is a real and substantial non-Federal tax
purpose germane to the business of the distributing corporation,  the controlled
corporation, or the affiliated group (as defined in Section 1.355-3(b)(4)(iv) of
the Regulations) to which the distributing corporation belongs.













 






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                                                              September 11, 1996






The business  purpose test  described in (vi) above should be satisfied  because
the  business   purpose  for  the   transaction  is  to  facilitate  a  tax-free
reorganization.  In order to complete  the  Acquisition  under the facts of this
case, Acquiring is requiring  Distributing to divest the assets described above.
The Service has long and  consistently  recognized that a spin-off made in order
to permit a tax-free  reorganization  involving the distributing  corporation is
supported by a business  purpose.  See Rev. Rul.  68-603,  1968-2 C.B. 148, Rev.
Rul.  70-434,  1970-2 C.B. 83, and Rev.  Rul.  78-251,  1978-1 C.B. 89. See also
Commissioner v. Morris Trust, 367 F. 2d 794 (4th Cir. 1966).

There  are  no  other  tax-free  alternatives  to  accomplishing  this  business
objective. Thus, Acquiring cannot simply acquire the stock of OTNC directly from
Distributing,   as  such  an   acquisition   would   subject   Distributing   to
characterization  as an  "investment  company" as that term is defined under the
Investment Company Act of 1940, 15 U.S.C. ss. 80a-1 et seq. (the "1940 Act"). If
Distributing  were an  investment  company it would be required to register with
the Securities and Exchange  Commission (the "SEC"), and would become subject to
the 1940 Act's pervasive regulatory framework. Failure to register would subject
Distributing  and its  management  to  administrative  and  judicial  penalties,
including the possible voiding of any contracts entered into by the company and,
possibly,  criminal conviction of its management.  Once a company registers with
the SEC as an  investment  company,  the  company and its  directors,  officers,
substantial shareholders and other related persons are subject to a broad set of
regulatory  restrictions  administered  by the  SEC  over a  great  many  areas,
including the  composition  of the board of directors,  incentive  compensation,
issuances of stock,  capital structure,  asset composition and transactions with
affiliates.

In addition,  Distributing's  management believes that if it held a large amount
of its assets in the form of Acquiring stock,  Controlled's  disease  management
activity would be severely  adversely  affected.  Thus, one of the objectives of
this  activity  is to provide the most  cost-effective  care,  including  use of
pharmaceuticals.  Further, Controlled's relationship with the oncology community
(including  payers)  is based  upon this cost  containment  premise.  Management
believes  that  Controlled's  credibility,   and  consequently  its  ability  to
function,  would be seriously  undermined if its 100 percent  parent held as the
bulk of its assets an  interest  in a large  pharmaceutical  company  devoted to
maximizing profits on pharmaceutical sales. It has been a long-standing position
of  the  Service  that a  customer's  reluctance  to  purchase  products  from a
corporation (or one of its group members) because of other business  activity of
the group is a












 






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                                                              September 11, 1996






valid  business  purpose  under Section 355 of the Code.  See Rev. Rul.  56-450,
1956-2 C.B. 201; Rev. Rul. 59-197, 1959-1 C.B. 77; PLRs 9539006 (June 27, 1995);
9524009  (March 15, 1995);  9438026 (June 28, 1994);  and 9331062  (February 17,
1993).

Continuity of Interest

Similarly, the continuity of interest requirement for a Section 355 distribution
will be satisfied  because 100 percent of the stock of Controlled  will be owned
by the  shareholders  of  Distributing.  After  the  Acquisition,  the  historic
shareholders  of  Distributing  will continue  their interest in the business of
Distributing through their stock ownership of Acquiring.  See, Rev. Rul. 68-603,
1968-2 C.B. 148, and Commissioner v. Morris Trust, 367 F.2d 794 (4th Cir. 1966).

Disqualified Distribution

Section  355 (d) of the  Code  provides  that,  in the  case of a  "disqualified
distribution,"  the  distributing  corporation  will recognize the gain (if any)
realized  on the  distribution  of the stock of the  controlled  corporation.  A
"disqualified  distribution" is defined as any distribution otherwise qualifying
under  Section 355 if,  immediately  after the  distribution,  any person  holds
"disqualified  stock"  in  the  distributing  or  controlled  corporation  which
constitutes   a   50-percent   or  greater   interest  in  either   corporation.
"Disqualified  stock"  is  defined  in  Section  355(d)(3)  as any  stock of the
distributing corporation acquired by purchase during the 5-year period ending on
the date of the distribution, and any stock of the controlled corporation either
acquired by purchase  during this 5-year period,  or  attributable  to purchased
distributing stock.

In the present case, no person has acquired a 50-percent or greater  interest in
the stock of Distributing  or Controlled  within the 5-year period ending on the
date of the distribution. Therefore, Section 355(d) will not apply to cause gain
recognition.

THE ACQUISITION OF DISTRIBUTING'S STOCK BY ACQUIRING.

Section 368(a)(1)(B) of the Code provides that the term "reorganization" (a Type
B  Reorganization)  includes the  acquisition  by one  corporation,  in exchange
solely for all or part of its voting stock, of stock of another  corporation if,
immediately after the acquisition, the












 






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                                                              September 11, 1996






acquiring  corporation  has control of such other  corporation.  Section  368(c)
provides that, for this purpose, the term "control" means the ownership of stock
possessing at least 80 percent of the total combined voting power of all classes
of stock  entitled to vote and at least 80 percent of the total number of shares
of all other classes of stock of the corporation.

The control  requirement will be met in this case, since, after the Acquisition,
Acquiring will own all of the stock of Distributing.  Similarly, the "solely for
voting stock"  requirement  will be satisfied,  as we understand  that Acquiring
will acquire that  Distributing  stock solely for its own voting stock. The fact
that the transaction  will be  accomplished  through a merger of a newly-created
subsidiary into Distributing does not prevent the transaction from qualifying as
a Type B  Reorganization.  See Rev. Rul. 67-448,  1967-2 C.B. 144. The fact that
some  of the  Acquiring  stock  will  be  placed  in  escrow  will  not  prevent
satisfaction of the applicable requirements.  Rev. Proc. 77-37, 1977-2 C.B. 568,
as amplified by Rev. Proc. 84-42, 1984-1 C.B. 521.

Section  1.368-1(b)  of  the  Regulations   imposes  the  following   additional
requirements  which must be met for a transaction to qualify as a reorganization
within the meaning of Section 368: (i) "continuity of interest" must be present,
(ii)  "continuity of business  enterprise"  must exist, and (iii) an appropriate
business purpose must be present.

Rev.  Proc.  77-37,  1977-2 C.B. 568 provides that the  "continuity of interest"
requirement is satisfied if there is continuing interest through stock ownership
in the  acquiring  corporation  on the part of the  former  shareholders  of the
acquired  corporation  which is equal in value,  as of the effective date of the
reorganization,  to at least 50 percent of all of the formerly outstanding stock
of the  acquired  corporation  as of that date.  Sales,  redemptions,  and other
dispositions  of stock  occurring  prior or subsequent to the exchange which are
part of the plan of  reorganization  will be considered in  determining  whether
there is a 50 percent  continuing  interest  through  stock  ownership as of the
effective date of the reorganization.  In the proposed transaction, based on the
representations  received,  former shareholders of Distributing will receive and
retain  stock  of  Acquiring  with a  value  (as of the  effective  date  of the
reorganization)  equal to 100 percent of the value of all  formerly  outstanding
stock of Distributing.  Therefore,  the continuity of interest guideline of Rev.
Proc. 77-37 will be met.

Section  1.368-1(b)  of the  Regulations  provides that a continuity of business
enterprise (as












 






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                                                              September 11, 1996






described  in  Section  1.368-1(d)  of  the  Regulations)  is a  requisite  to a
reorganization.  Section 1.368-1(d) of the Regulations  provides that continuity
of business enterprise  requires that the acquiring  corporation either continue
the acquired corporation's historic business or use a significant portion of the
acquired  corporation's  historic assets in a business. The proposed transaction
will meet the  continuity  of  business  enterprise  requirement  as it has been
represented  that, after the transaction,  Distributing  will be engaged through
OTNC in its historic  Distribution  Business.  See Rev. Rul. 85-198, 1985-2 C.B.
121.  The fact that all  partnership  assets  and  liabilities  will now be held
directly by OTNC should not change this result.

Section  1.368-2(g) of the Regulations  provides that a  reorganization  must be
undertaken  for  reasons  germane  to  the  continuance  of  the  business  of a
corporation a party to the  reorganization.  As described above, the Acquisition
will  be  undertaken  for  substantial  business  reasons.  Thus,  the  proposed
transaction will be motivated by a valid business purpose in accordance with the
Regulations.

Section  368(b) of the Code  defines the term "a party to a  reorganization"  to
include a corporation resulting from a reorganization, and both corporations, in
the case of a  reorganization  resulting from the acquisition by one corporation
of stock or properties of another.

Section 354(a)(1)  provides that no gain or loss shall be recognized if stock or
securities in a corporation a party to a reorganization are, in pursuance of the
plan of  reorganization,  exchanged  solely  for  stock  or  securities  in such
corporation or in another corporation a party to the reorganization.


                         FEDERAL INCOME TAX CONSEQUENCES

Based solely upon the facts and information  presented in the Documents,  and on
the  information  set forth in this opinion  letter and subject to the "SCOPE OF
OPINION,"  described below, it is our opinion that the following  Federal income
tax consequences should result from the Proposed Transaction described above:

(1)     The transfer by  Distributing to Controlled of the assets other than the
        Wanted Assets












 






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                                                              September 11, 1996






        solely in constructive  exchange for additional  stock of Controlled and
        the assumption of certain liabilities,  as described above,  followed by
        the distribution of the Controlled stock pro rata to the shareholders of
        Distributing  should qualify as a  reorganization  within the meaning of
        Section  368(a)(1)(D) of the Code.  Distributing  and Controlled  should
        each be "a party to a  reorganization"  within  the  meaning  of Section
        368(b).

(2)     No gain or loss will be recognized to Distributing  upon the transfer of
        the  assets,  subject to  liabilities,  to  Controlled  in  constructive
        exchange for Controlled stock (Sections 351(a), 361(a) and 357(a)).

(3)     No gain or loss will be  recognized  by  Controlled  upon the receipt of
        assets in constructive exchange for Controlled stock (Section 1032(a)).

(4)     The basis of the assets  received by Controlled  will be the same as the
        basis of such assets in the hands of Distributing  immediately  prior to
        the Proposed Transaction (Section 362(b)).

(5)     The holding  period of the  Distributing  assets  received by Controlled
        will  include  the  period   during  which  such  assets  were  held  by
        Distributing (Section 1223(2)).

(6)     No gain or loss  should  be  recognized  to  (and no  amount  should  be
        included in the income of) the  shareholders  of  Distributing  upon the
        receipt of the Controlled stock (Section 355(a)(1)).

(7)     No  gain  or  loss  should  be  recognized  to  Distributing   upon  the
        distribution  of the Controlled  stock pro rata to the  shareholders  of
        Distributing (Section 361(c)(1)).

(8)     The basis of the Controlled and  Distributing  stock in the hands of the
        shareholders  of  Distributing  should  be the same as the  basis of the
        Distributing stock held by the shareholders of Distributing  immediately
        before the  distribution,  allocated  in  proportion  to the fair market
        value  of  each  in  accordance  with  Section   1.358-2(a)(2)   of  the
        Regulations (Section 358(b)(1)).

(9)     As provided in Section 312(h) of the Code, proper allocation of earnings
        and profits












 






Board of Directors                                                       Page 21
                                                              September 11, 1996






        between  Distributing  and Controlled  should be made in accordance with
        Section 1.312-10(a) of the Regulations.

(10)    Provided the Distributing  stock was held as a capital asset on the date
        of the  distribution of the Controlled  stock, the holding period of the
        Controlled  stock received by the  shareholders of  Distributing  should
        include the holding  period of the  Distributing  stock with  respect to
        which the distribution was made (Section 1223(1)).

(11)    The acquisition by Acquiring of all the stock of Distributing  solely in
        exchange for  Acquiring  stock,  as described  above,  will qualify as a
        reorganization under Section 368(a)(1)(B) of the Code.  Distributing and
        Acquiring will each be "a party to a reorganization"  within the meaning
        of Section 368(b).

(12)    No gain or loss will be recognized by the Distributing shareholders upon
        the receipt of Acquiring stock solely in exchange for Distributing stock
        (Section 354(a)(1)).

(13)    The basis of the Acquiring stock received by Distributing's shareholders
        in exchange for Distributing  stock will be the same as the basis of the
        Distributing stock surrendered in exchange therefor (Section 358(a)(1)).

(14)    The holding period of the Acquiring  stock received by the  Distributing
        shareholders  in the  Exchange  will  include the holding  period of the
        Distributing  stock  surrendered  in  exchange  therefor,  provided  the
        Distributing  stock  is held as a  capital  asset  in the  hands  of the
        Distributing shareholders on the date of the exchange (Section 1223(1)).


                                SCOPE OF OPINION

The scope of this opinion is expressly  limited to the Federal income tax issues
specifically  addressed  in (1) through  (14) in the section  entitled  "FEDERAL
INCOME TAX CONSEQUENCES" above. We have made no determination, nor expressed any
opinion  as to any  limitations,  including  those  which may be  imposed  under
Section 382, on the  availability  of net operating loss carryovers (or built-in
losses), if any, after the Proposed Transaction, the application (if any) of the
alternative minimum tax to the Proposed Transaction, or on any












 






Board of Directors                                                       Page 22
                                                              September 11, 1996






consolidated  return,  employee  benefit,  or foreign  tax  (including,  without
limitation,  the  application of Section 367 of the Code) issues which may arise
as  a  result  of  the  Proposed  Transaction.   Similarly,   we  have  made  no
determination   nor  expressed  any  opinion   regarding  the   consequences  to
Distributing  shareholders entitled to special treatment under the Code (such as
insurance companies,  dealers in securities,  or tax exempt organizations) or to
Distributing  shareholders  who  acquired  their  shares of  Distributing  stock
pursuant to the exercise of employee stock options or otherwise in  compensatory
transactions. In addition, we have expressed no opinion on the conversion of the
Distributing  preferred into common stock,  on the exercise of the  Distributing
options,  the  recapitalization  of  Controlled,   the  transfer  of  assets  or
liabilities to  Distributing  or any of its direct or indirect  subsidiaries  in
anticipation  of,  or as  part  of,  the  Proposed  Transaction  (other  than as
described in (1) above), or on the effect of any arrangements  between Acquiring
or its  subsidiaries  and  Controlled  or  its  subsidiaries  subsequent  to the
Acquisition.  Furthermore,  our  opinion  has not  been  requested,  and none is
expressed,  with  respect to any  foreign,  state or local tax  consequences  to
Distributing, Controlled, or the shareholders of Distributing.

We note  that any  variation  or  differences  in the  facts or  representations
recited  herein,  for any reason,  might affect our  conclusions,  perhaps in an
adverse manner, and may make them inapplicable.  Further, our opinions are based
upon the analysis of the Code, the Regulations thereunder, current case law, and
published  rulings.  The foregoing are subject to change, and such change may be
retroactively  effective.  If so, our views, as set forth above, may be affected
and may not be relied upon.  We have  undertaken  no  obligation to update these
opinions for changes in facts or law  occurring  subsequent to the date thereof.
We do note  that on March  19,  1996,  the  Clinton  Administration  sent to the
Congress a proposal  (the  "Proposal")  to require gain  recognition  on certain
Section  355  distributions  when  at  least  50  percent  of the  stock  of the
distributing  or the controlled  corporation is not held at all times during the
four year  period  commencing  two years  before and ending two years  after the
distribution  by the  direct  and  indirect  shareholders  of  the  distributing
corporation.  If  the  Proposal  were  applicable  to the  instant  transaction,
Distributing  would be  required  to  recognize  gain (if any)  realized  on the
distribution of the Controlled stock since the shareholders of Distributing will
own less than 50  percent of the stock of  Acquiring.  The  Proposal  would not,
however, change the treatment of Distributing's  shareholders,  described above.
While the Proposal  stated that the provisions  would generally be effective for
distributions  after March 19, 1996, a statement by Senator Roth and Congressman
Archer issued on March 29, 1996, indicated that "it is intended that the












 






Board of Directors                                                       Page 23
                                                              September 11, 1996





effective   date.  .  .  will  be  no  earlier  than  the  date  of  appropriate
Congressional action." We express no opinion regarding whether the Proposal will
or will not be applicable to the proposed transaction.

This letter is not intended to be, and should not be, distributed or relied upon
by  any   entities  or  persons   other  than   Distributing,   Controlled   and
Distributing's  shareholders.  In addition, except as expressly set forth above,
this letter  should not be quoted or otherwise  referred to in any  documents or
filed  with or  furnished  to any  agency  (other  than  with the  Service  upon
examination) without the express written consent of Ernst & Young LLP.

This letter is an opinion of our firm as to the  interpretation  of existing law
and, as such, is not binding on the Service or the courts.

                                                   Very truly yours,

                                                   /s/ Ernst & Young LLP



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