1
                                                                  CONFORMED COPY




                              FACILITIES AGREEMENT

                                     between

                INVERESK RESEARCH GROUP LIMITED AND SUBSIDIARIES

                                       and

                       BEAR STEARNS CORPORATE LENDING INC
                           as Lender, Arranger, Agent,
                    Security Trustee and Working Capital Bank

- --------------------------------------------------------------------------------
                           SENIOR SERIES 1 TERM LOANS
                           SENIOR SERIES 2 TERM LOANS
                  C$15,300,000 CAPITAL EXPENDITURE FACILITY AND
                       L6,000,000 WORKING CAPITAL FACILITY
- --------------------------------------------------------------------------------
                       [McGRIGOR DONALD SOLISITORS LOGO]

                                  Erskine House
                               68-73 Queen Street
                                    EDINBURGH
                                     EH2 4NF
                            Telephone: 0131 226 7777
                            Facsimile: 0131 226 7700
                         E-Mail: enquiries@mcgrigors.com
                       Web Site: http://www.mcgrigors.com


   2
                                TABLE OF CONTENTS



CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
1             DEFINITIONS AND INTERPRETATION.........................................................1
1.1           Definitions............................................................................1
1.2           Construction..........................................................................24
1.3           Currency Conversion...................................................................26

2             THE FACILITIES........................................................................26
2.1           The Facilities........................................................................26
2.2           Lender's rights and obligations.......................................................27

3             PURPOSE AND CONDITIONS PRECEDENT......................................................27
3.1           Purpose...............................................................................27
3.2           Monitoring............................................................................27
3.3           Initial conditions precedent..........................................................27
3.4           Additional Acquisition Term Loans conditions precedent................................28
3.5           Further conditions precedent..........................................................28
3.6           Certain Funds Period..................................................................29
3.7           Maximum number of Loans...............................................................30
3.8           Conditions relating to Capital Expenditure Facility...................................30

4             UTILISATION OF TERM LOANS.............................................................30
4.1           Series 1 Term Facilities, Series 2 Term Facilities and Capital Expenditure Facilities.30

5             RE-DENOMINATION OF ACQUISITION TERM LOANS.............................................31
5.1           Parent's Option.......................................................................31
5.2           Agent's Option........................................................................31
5.3           Notice................................................................................31
5.4           Re-Denomination Amount................................................................32
5.5           Re-Denomination of Commitments........................................................32

6             THE WORKING CAPITAL FACILITY..........................................................32
6.1           Nature of Facility....................................................................32
6.2           Utilisation...........................................................................32
6.3           Optional Currencies...................................................................33
6.4           Exchange rate movements...............................................................34
6.5           FFE Contracts.........................................................................35
6.6           Bank Guarantees.......................................................................35
6.7           Guarantee Request.....................................................................36
6.8           Counter Indemnity from the Borrowers..................................................36
6.9           Counter Indemnity from the Working Capital Lenders....................................37
6.10          Working Capital Banks Participation...................................................37
6.11          Interest on Payments..................................................................38

7             REPAYMENT.............................................................................38
7.1           Repayment of Series 1 Term Facilities.................................................38
7.2           Repayment of Series 2 Term Facilities.................................................39
7.3           Repayment of Capital Expenditure Facility.............................................39
7.4           Repayment of Working Capital Facility.................................................40

8             prepayment and cancellation...........................................................40
8.1           Illegality............................................................................40

                                      (i)
   3


CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
8.2           Change of control/Listing/Sale........................................................41
8.3           Unapplied Net Proceeds................................................................41
8.4           Insurance Claims......................................................................42
8.5           Relevant Receipts.....................................................................42
8.6           Notice................................................................................43
8.7           Cash Sweep............................................................................43
8.8           Voluntary cancellation................................................................43
8.9           Voluntary prepayment of Series 1 Term Facilities......................................43
8.10          Voluntary Prepayment of Series 2 Term Facilities......................................44
8.11          Voluntary Prepayment of Capital Expenditure Facility..................................44
8.12          Right of repayment and cancellation in relation to a single Lender....................44
8.13          Restrictions..........................................................................45

9             INTEREST ETC..........................................................................45
9.1           Series 1 Term Facilities, Series 2 Term Facilities and Capital Expenditure Facilities.46
9.2           Working Capital Facility..............................................................46

10            Interest Periods......................................................................48
10.1          Selection of Interest Periods.........................................................48
10.2          Changes to Interest Periods...........................................................49
10.3          Non-Business Days.....................................................................49

11            Changes to the calculation of interest................................................49
11.1          Absence of quotations.................................................................49
11.2          Market disruption.....................................................................49
11.3          Alternative basis of interest or funding..............................................50
11.4          Break Costs...........................................................................50

12            Fees..................................................................................51
12.1          Commitment fees.......................................................................51

13            Tax gross up and indemnities..........................................................51
13.1          Definitions...........................................................................51
13.2          Tax gross-up..........................................................................52
13.3          Tax indemnity.........................................................................53
13.4          Tax Credit............................................................................53
13.5          Stamp taxes...........................................................................54
13.6          Value added tax.......................................................................54

14            Increased costs.......................................................................54
14.1          Increased costs.......................................................................54
14.2          Increased cost claims.................................................................54
14.3          Exceptions............................................................................55

15            Other indemnities.....................................................................55
15.1          Currency indemnity....................................................................55
15.2          Other indemnities.....................................................................55
15.3          Indemnity to the Agent................................................................56

16            Mitigation by the FINANCE PARTIES.....................................................56
16.1          Mitigation............................................................................56


                                      (ii)
   4


CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
16.2          Limitation of liability...............................................................56

17            Costs and expenses....................................................................56
17.1          Transaction expenses..................................................................56
17.2          Amendment costs.......................................................................57
17.3          Enforcement costs.....................................................................57

18            Guarantee and indemnity...............................................................57
18.1          Guarantee and indemnity...............................................................57
18.2          Continuing guarantee..................................................................58
18.3          Reinstatement.........................................................................58
18.4          Waiver of defences....................................................................58
18.5          Immediate recourse....................................................................59
18.6          Appropriations........................................................................59
18.7          Deferral of Guarantors' rights........................................................59
18.8          Additional security...................................................................59

19            Representations.......................................................................59
19.1          Status................................................................................60
19.2          Power and Authority...................................................................60
19.3          Binding Obligations...................................................................60
19.4          Non-conflict with other obligation....................................................60
19.5          No default............................................................................60
19.6          No proceedings pending or threatened..................................................60
19.7          No Security...........................................................................61
19.8          Corporate Structure...................................................................61
19.9          No Borrowings.........................................................................61
19.10         Business Plan.........................................................................61
19.11         Reports...............................................................................61
19.12         Transaction Document representations..................................................62
19.13         Target Accounts.......................................................................62
19.14         Taxes.................................................................................62
19.15         Intellectual Property Rights..........................................................62
19.16         Environmental.........................................................................63
19.17         ERISA.................................................................................63
19.18         Licences..............................................................................64
19.19         Material Facts........................................................................64
19.20         Financial statements..................................................................64
19.21         Merger................................................................................65
19.22         Margin Stock..........................................................................65
19.23         Solvency..............................................................................65
19.24         Repetition............................................................................66
19.25         Limitation During Availability Period.................................................66

20            Information undertakings..............................................................66
20.1          Financial Information.................................................................66
20.2          Financial Statements..................................................................67
20.3          Investigation.........................................................................67

21            Financial covenants...................................................................68
21.1          Covenants.............................................................................68


                                     (iii)
   5


CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
21.2          Exchange rate adjustment..............................................................74

22            General undertakings..................................................................74
22.1          Positive Undertakings.................................................................74
22.2          Negative Undertakings.................................................................79
22.3          Ringfenced Undertakings...............................................................82
22.4          Merger - related undertakings.........................................................83

23            Events of Default.....................................................................83
23.1          Non-payment...........................................................................84
23.2          Certain Obligations...................................................................84
23.3          Other Obligations.....................................................................84
23.4          Misrepresentation.....................................................................84
23.5          Cross default.........................................................................84
23.6          Inability to pay debts................................................................84
23.7          Legal Process.........................................................................85
23.8          Insolvency Proceedings................................................................85
23.9          Insolvency order......................................................................85
23.10         Administration........................................................................85
23.11         Repossession of goods.................................................................85
23.12         Analogous proceedings.................................................................85
23.13         Change of Control.....................................................................86
23.14         Management Team.......................................................................86
23.15         Litigation............................................................................86
23.16         Subsidiaries..........................................................................86
23.17         Invalidity............................................................................86
23.18         Change in nature of business..........................................................86
23.19         Licences..............................................................................87
23.20         Qualified Accounts....................................................................87
23.21         Inter Creditor Deed...................................................................87
23.22         ERISA Termination Event...............................................................87
23.23         Material Adverse Effect...............................................................87
23.24         Acceleration..........................................................................87
23.25         Limitation During Availability Period.................................................88

24            Changes to the Lenders................................................................88
24.1          Assignment and Transfers by the Lenders...............................................88
24.2          Obligations...........................................................................88
24.3          Parent undertaking....................................................................88
24.4          Lenders ability to sub-contract.......................................................89
24.5          Limitation of responsibility of Existing Lenders......................................89
24.6          Procedure for transfer................................................................89
24.7          Disclosure of information.............................................................90

25            Changes to the Obligors...............................................................90
25.1          Assignations and transfer by Obligors.................................................90
25.2          Additional Borrowers..................................................................91
25.3          Resignation of a Borrower.............................................................91
25.4          Additional Guarantors.................................................................91
25.5          Repetition of Representations.........................................................92
25.6          Resignation of a Guarantor............................................................92


                                      (iv)
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CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
26            SYNDICATION...........................................................................92
26.1          Obligors' undertakings................................................................92
26.2          Costs of Syndication..................................................................93

27            Role of the Agent, THE SECURITY TRUSTEE and the Arranger..............................93
27.1          Appointment of the Agent..............................................................93
27.2          Duties of the Agent...................................................................93
27.3          Role of the Arranger..................................................................93
27.4          No fiduciary duties...................................................................93
27.5          Business with the Group...............................................................94
27.6          Rights and discretions of the Agent...................................................94
27.7          Majority Lenders' instructions........................................................94
27.8          Responsibility for documentation......................................................95
27.9          Exclusion of liability................................................................95
27.10         Lenders' indemnity to the Agent.......................................................95
27.11         Resignation of the Agent..............................................................96
27.12         Confidentiality.......................................................................96
27.13         Relationship with the Finance Parties.................................................96
27.14         Credit appraisal by the Finance Parties...............................................97
27.15         Finance Party's tax status confirmation...............................................97
27.16         Reference Lenders.....................................................................98
27.17         Appointment of the Security Trustee...................................................98

28            Conduct of business by the Finance Parties............................................98

29            Sharing among the Lenders.............................................................98
29.1          Payments to Lenders...................................................................98
29.2          Redistribution of payments............................................................99
29.3          Recovering Lender's rights............................................................99
29.4          Reversal of redistribution............................................................99
29.5          Exceptions............................................................................99

30            Payment mechanics....................................................................100
30.1          Payments to the Agent................................................................100
30.2          Distributions by the Agent...........................................................100
30.3          Distributions to an Obligor..........................................................100
30.4          Clawback.............................................................................100
30.5          Partial payments.....................................................................100
30.6          No set-off by Obligors...............................................................101
30.7          Business Days........................................................................101
30.8          Currency of account..................................................................101
30.9          Change of currency...................................................................102

31            Set-off..............................................................................102

32            Notices..............................................................................102
32.1          Communications in writing............................................................102
32.2          Addresses............................................................................102
32.3          Delivery.............................................................................103
32.4          Notification of address, fax number and telex number.................................104


                                      (v)
   7


CLAUSE        HEADING                                                                            PAGE NO.
- ------        -------                                                                            --------
                                                                                           
32.5          English language.....................................................................104

33            ANNOUNCEMENTS........................................................................104

34            Calculations and certificates........................................................104
34.1          Accounts.............................................................................104
34.2          Certificates and Determinations......................................................105
34.3          Day count convention.................................................................105

35            Partial invalidity...................................................................105

36            Remedies and waivers.................................................................105

37            Amendments and waivers...............................................................105
37.1          Required consents....................................................................105
37.2          Exceptions...........................................................................105

38            Governing law........................................................................106

39            Enforcement..........................................................................106
39.1          Jurisdiction of English courts.......................................................106
39.2          Service of process...................................................................106

SCHEDULE 1 The Original Obligors...................................................................107
SCHEDULE 2 The Original Lenders....................................................................108
SCHEDULE 3 Conditions Precedent....................................................................109
SCHEDULE 4 Utilisation Request.....................................................................114
SCHEDULE 5 Selection Notice........................................................................115
SCHEDULE 6 Mandatory Cost Formula..................................................................116
SCHEDULE 7 Form of Transfer Certificates...........................................................118
SCHEDULE 8 Form of Accession Letter................................................................119
SCHEDULE 9 Form of Resignation Letter..............................................................120
SCHEDULE 10 Form of Compliance Certificate.........................................................121
SCHEDULE 11 Timetables.............................................................................122
SCHEDULE 12 Post Merger Group Structure............................................................123
SCHEDULE 13 Form of Guarantee Request..............................................................126
SCHEDULE 14 Clinical Group Members.................................................................127
SCHEDULE 15 Key Man Insurance......................................................................128
SCHEDULE 16 Part 1 Material Companies..............................................................129
SCHEDULE 16 Part 2 Dormant Companies...............................................................130
SCHEDULE 16 Part 3 Overseas Companies..............................................................131


                                      (vi)
   8
THIS AGREEMENT is dated 22 February 2001 and made between:


(1)        INVERESK RESEARCH GROUP LIMITED incorporated in Scotland (Registered
           Number 198206) whose registered office is at Elphinstone Research
           Centre, Tranent, East Lothian, EH33 2NE (the "PARENT");

(2)        INVERESK RESEARCH (CANADA) INC incorporated in Canada with number
           3844481 and having its registered office at 1170 Peel Street,
           Montreal, Quebec H3B 4S8 ("CANADA HOLDCO");

(3)        THE SUBSIDIARIES of the Parent listed in Schedule 1 as original
           guarantors (together with the Parent and Canada Holdco the "ORIGINAL
           GUARANTORS");

(4)        BEAR STEARNS CORPORATE LENDING INC ("ARRANGER");

(5)        THE FINANCIAL INSTITUTION stated in Schedule 2 as lender (the
           "ORIGINAL LENDER");

(6)        BEAR STEARNS CORPORATE LENDING INC as agent of the Lenders (the
           "AGENT");

(7)        BEAR STEARNS CORPORATE LENDING INC as security trustee for the
           Lenders (the "SECURITY TRUSTEE"); and

(8)        BEAR STEARNS CORPORATE LENDING INC as Working Capital Bank (the
           "WORKING CAPITAL BANK").

1        DEFINITIONS AND INTERPRETATION

1.1      DEFINITIONS


           In this Agreement:


           "ACCESSION LETTER" means a document substantially in the form set out
           in Schedule 8;


           "ACCOUNTANT'S REPORT" means the due diligence report prepared by
           Arthur Andersen in the agreed form;


           "ADDITIONAL BORROWER" means a company which becomes an Additional
           Borrower in accordance with Clause 25.2;


           "ADDITIONAL GUARANTOR" means a company which becomes an Additional
           Guarantor in accordance with Clause 25.4;


           "ADDITIONAL OBLIGOR" means an Additional Borrower or an Additional
           Guarantor;


           "AFFILIATE" means, in relation to any person, a Subsidiary of that
           person or a Holding Company of that person or any other Subsidiary of
           that Holding Company;


           "AGENT'S SPOT RATE OF EXCHANGE" means, in relation to any amount and
           any Facility, the Agent's spot rate of exchange for the purchase of
           the relevant currency


                                       1
   9
           with the Base Currency of the relevant Facility in the London foreign
           exchange market at or about 11.00 am on a particular day;


           "APPROPRIATE ACCOUNTING PRINCIPLES" means the accounting principles,
           policies, standards, practices and bases stated:

           (a)       with regard to Target Group Companies (and any Subsidiaries
                     of the Target from time to time other than present
                     Subsidiaries of the Target), in the Target Accounts; and

           (b)       with regard to Group Companies other than any falling
                     within the foregoing paragraph (a), in the Original
                     Financial Statements;


           "APPROVED FINANCIER" means any institution (funding or proposing to
           fund the activities of the Clinical Group) approved in writing by the
           Agent (such approval not to be unreasonably withheld or delayed);


           "ARTICLES" means the Articles of Association of the Parent in the
           agreed form and adopted by the Parent on or around the date hereof;


           "AUDITORS" means in relation to each Group Company Arthur Andersen,
           chartered accountants, of 18 Charlotte Square, Edinburgh EH2 4DF or,
           as the case may be, such other reputable firm of chartered
           accountants of international repute as shall have been approved in
           writing by the Agent and appointed as auditors of the relative member
           of the Group;


           "AUTHORISATION" means an authorisation, consent, approval,
           resolution, licence, exemption, filing or registration;


           "AVAILABILITY PERIOD" means:

           (a)       in relation to the Series 1 Term Facilities and the Series
                     2 Term Facilities, the period from and including the date
                     of this Agreement to and including the earliest of:

                     (i)        the Closing;

                     (ii)       the date, if any, upon which the Merger
                                Agreement terminates; and

                     (iii)      the date falling 12 months (or such longer
                                period as the Agent may agree) after the signing
                                of the Merger Agreement;

           (b)       in relation to the Capital Expenditure Facility, the period
                     from and including the date of this Agreement to and
                     including 30 June 2002; and

           (c)       in relation to the Working Capital Facility, the period
                     from and including the date of this Agreement to and
                     including 31 December 2007;


                                       2
   10
           "AVAILABLE COMMITMENT" means, in relation to a Facility, a Lender's
           Commitment under that Facility minus:

           (a)       the amount of its participation in any outstanding Loans or
                     Utilisations under that Facility; and

           (b)       in relation to any proposed Utilisation, the amount of its
                     participation in any Loans or Utilisations that are due to
                     be made under that Facility on or before the proposed
                     Utilisation Date;


           "AVAILABLE FACILITY" means, in relation to a Facility, the aggregate
           for the time being of each Lender's Available Commitment in respect
           of that Facility;


           "BANK GUARANTEE" means a Guarantee issued or undertaken or made or,
           as the case may be, proposed to be issued, undertaken or made by the
           Working Capital Bank under the Working Capital Facility in the agreed
           form;


           "BASE CURRENCY" means Sterling in respect of the Parent Series 1
           Refinancing Term Facility and the Parent Series 2 Refinancing Term
           Facility; US$ until the relevant Re-Denomination Date and thereafter
           Canadian Dollars in respect of the Canada Holdco Series 1 Acquisition
           Term Facility and the Canada Holdco Series 2 Acquisition Term
           Facility; US$ until the relevant Re-Denomination Date and thereafter
           Sterling in respect of the Parent Series 1 Acquisition Term Facility
           and the Parent Series 2 Acquisition Term Facility; Canadian Dollars
           in respect of the Capital Expenditure Facility; and Sterling in
           respect of the Working Capital Facility;


           "BORROWER" means an Original Borrower or an Additional Borrower
           unless it has ceased to be a Borrower in accordance with Clause 25.3;


           "BORROWER INDEMNITY" means in relation to a Borrower the indemnity
           given by that Borrower to the Working Capital Bank pursuant to Clause
           6.8 in respect of a Bank Guarantee;


           "BREAK COSTS" means the amount (if any) by which:

           (a)       the interest which a Lender should have received for the
                     period from the date of receipt of all or any part of its
                     participation in a Loan or Utilisation or Unpaid Sum to the
                     last day of the current Interest Period in respect of that
                     Loan or Utilisation or Unpaid Sum, had the principal amount
                     or Unpaid Sum received been paid on the last day of that
                     Interest Period;


           exceeds:

           (b)       the amount which that Lender would be able to obtain by
                     placing an amount equal to the principal amount or Unpaid
                     Sum received by it on deposit with a leading bank in the
                     Relevant Interbank Market for a period starting on the
                     Business Day following receipt or recovery and ending on
                     the last day of the current Interest Period;


           "BUSINESS DAY" means a day (other than a Saturday or Sunday) on which
           banks are open for general business in London, Montreal and, until
           the Re-denomination Date only, New York;


                                       3
   11
           "BUSINESS PLAN" means the business plan in the agreed form;


           "CANADA HOLDCO SERIES 1 ACQUISITION TERM FACILITY" means the term
           loan facility made available under this Agreement and described in
           Clause 2.1.2(a);


           "CANADA HOLDCO SERIES 1 ACQUISITION TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender, the amount in the Base
                     Currency set under its name opposite the words "Canada
                     Holdco Series 1 Acquisition Term Facility Commitment" in
                     Schedule 2 (or the relevant Re-denominated Commitment
                     Amount) and the amount of any other Canada Holdco Series 1
                     Acquisition Term Facility Commitment transferred to it
                     under this Agreement; and

           (b)       in relation to any other Lender, the amount in the Base
                     Currency of any Canada Holdco Series 1 Acquisition Term
                     Facility Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "CANADA HOLDCO SERIES 1 ACQUISITION TERM FACILITY LOAN" means a loan
           made or to be made under the Canada Holdco Series 1 Acquisition Term
           Facility or the principal amount outstanding for the time being of
           that loan;


           "CANADA HOLDCO SERIES 2 ACQUISITION TERM FACILITY" means the term
           loan facility made available under this Agreement and described in
           Clause 2.1.2(b);


           "CANADA HOLDCO SERIES 2 ACQUISITION TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender the amount in the Base
                     Currency set under its name opposite the words "Canada
                     Holdco Series 2 Acquisition Term Facility Commitment" in
                     Schedule 2 (or the relevant Re-Denominated Commitment
                     Amount) and the amount of any other Canada Holdco Series 2
                     Acquisition Term Facility Commitment transferred to it
                     under this Agreement; and

           (b)       in relation to any other Lender, the amount in the Base
                     Currency of any Canada Holdco Series 2 Acquisition Term
                     Facility Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "CANADA HOLDCO SERIES 2 ACQUISITION TERM FACILITY LOAN" means a loan
           made or to be made under the Canada Holdco Series 2 Acquisition Term
           Facility or the principal amount outstanding for the time being of
           that loan;


           "CANADIAN DOLLARS" and "C$" means the lawful currency of Canada;


           "CANADIAN FINANCIAL ASSISTANCE DOCUMENTS" means the documentation
           demonstrating satisfaction by Clintrials BioResearches Limited of
           s123.66 of the Companies Act (Quebec) in connection with the grant of
           the Security Documents to be executed by those companies, in a form
           acceptable to the Agent acting reasonably;


                                       4
   12
           "CANADIAN REPORT ON TITLE" means the report on title in respect of
           Clintrials BioResearches Limited's facility at 87 Senneville Road,
           Senneville, Quebec, H9X 3R3 to be prepared by Desjardins Ducharme
           Stein Monast;


           "CAPITAL EXPENDITURE FACILITY" means the term loan facility made
           available under this Agreement and described in Clause 2.1.2(c);


           "CAPITAL EXPENDITURE FACILITY COMMITMENT" means;

           (a)       in relation to an Original Lender, the amount in the Base
                     Currency set under its name opposite the words "Capital
                     Expenditure Facility Commitment" in Schedule 2 and the
                     amount of any other Capital Expenditure Facility Commitment
                     transferred to it under this Agreement; and

           (b)       in relation to any other Lender, the amount in the Base
                     Currency of any Capital Expenditure Facility Commitment
                     transferred to it under this Agreement,


           to the extent not cancelled reduced or transferred by it under this
           Agreement;


           "CAPITAL EXPENDITURE FACILITY LOAN" means a loan made or to be made
           under the Capital Expenditure Facility or the principal amount
           outstanding for the time being of that loan;


           "CASH COLLATERAL ACCOUNTS" has the meaning given in Clause 6.4.3;


           "CLEAN UP DATE" means the date falling three months after Closing;


           "CLINICAL GROUP" means those companies listed in Schedule 14 together
           with any other members of the Group (other than Inveresk Clinical
           Research Limited) engaged in clinical trials operations from time to
           time; and "CLINICAL GROUP MEMBERS" shall be construed accordingly;


           "CLOSING" shall have the meaning ascribed thereto in the Merger
           Agreement;


           "COMMITMENT" means a Parent Series 1 Refinancing Term Facility
           Commitment, a Parent Series 2 Refinancing Term Facility Commitment, a
           Parent Series 1 Acquisition Term Facility Commitment, a Parent Series
           2 Acquisition Term Facility Commitment, a Canada Holdco Series 1
           Acquisition Term Facility Commitment a Canada Holdco Series 2
           Acquisition Term Facility Commitment, a Capital Expenditure Facility
           Commitment or a Working Capital Facility Commitment;


           "COMMON STOCK PRICE" shall have the meaning given thereto in the
           Merger Agreement;


           "COMPLIANCE CERTIFICATE" means a certificate substantially in the
           form set out in Schedule 10;


           "DEFAULT" means an Event of Default or any event or circumstance
           which would (with the expiry of a grace period, the giving of any
           notice, the making of any determination, lapse of time and/or the
           satisfaction of any of the conditions, in each case under Clause 23)
           be an Event of Default;


                                       5
   13
           "DISTRIBUTION" means any dividend or other distribution whether in
           cash or in specie which is declared or due and whether or not
           actually paid;


           "DORMANT COMPANIES" means any Group Company which has not traded or
           has ceased trading (all such companies as at the date of execution of
           this Agreement being listed in Part 2 of Schedule 16);


           "DRAWDOWN DATE" means the date of first drawdown under the Series 1
           Term Facilities or the Series 2 Term Facilities;


           "EMPLOYEE BENEFIT PLAN" means any employees benefit plan within the
           meaning of Section 3(3) of ERISA which:

           (a)       is maintained for employees of any Borrower or any ERISA
                     Affiliate; or

           (b)       has at any time within the preceding six years been
                     maintained for the employees of any Borrower or any current
                     or former ERISA Affiliate;


           "ENVIRONMENT" means all or any gases, airs, vapours, liquids, land
           (including building and any other structures, enclosures or erections
           in, on or under it and any rock or soil and anything below the
           surface of it), flora, fauna, wetlands, land covered with water and
           water (including sea, ground and surface water) and all other nature
           resources of any kind;


           "ENVIRONMENTAL LAW" means all or any laws, statutes, treaties,
           regulations, directives, ordinances, rules publicly available codes
           of practice, circulars, guidance and notices having legal or judicial
           import or effect whether of a criminal, civil or administrative
           nature and the rules of common law concerning:

           (a)       pollution or contamination of the Environment;

           (b)       harm, whether actual or potential, to mankind and human
                     sense, living organisms and ecological systems;

           (c)       the generation, manufacture, processing, distribution, use
                     (including abuse), treatment, storage, disposal, transport
                     or handling of Dangerous Substances; and

           (d)       the emission, leakage, release or discharge into the
                     Environment of noise, vibration, dusts, fumes, gas, odours,
                     smoke, steam effluvia, heat, light, radiation (of any
                     kind), infection, electricity or any Dangerous Substance
                     and any matter or thing capable of constituting a nuisance
                     or an actionable wrong of any kind in respect of such
                     matters;


           for these purposes "DANGEROUS SUBSTANCE" means any radioactive
           emissions and any natural or artificial substance (whether in solid
           or liquid form or in the form of a gas or vapour and whether alone or
           in combination with any other substance) capable of causing harm to
           man or any other living organism or damaging the Environment or
           public health or welfare, including (without limitation) any
           controlled, special, hazardous, toxic, radioactive or dangerous
           waste;


           "ENVIRONMENTAL REPORT" means the report in agreed form prepared by
           Marsh UK Ltd;


                                       6
   14
           "EQUITY DOCUMENTS" means the Investment Agreement, the Articles and
           the Loan Stock Instrument;


           "EQUIVALENT AMOUNT" means in respect of any Loan requiring to be
           re-denominated pursuant to Clause 5 an amount in Canadian Dollars or
           Sterling (as appropriate having regard to the required currency of
           re-denomination) which could be purchased with the relevant amount of
           US$ at the Agent's spot buying rate for Canadian Dollars or Sterling
           against US$ at or about 11.00 am on the second Business Day preceding
           the Re-denomination Date;


           "ERISA" means the Employee Retirement Income Security Act of 1974 (of
           the United States of America), and the rules and regulations
           thereunder, each as amended, supplemented or otherwise modified;


           "ERISA AFFILIATE" means any person who together with any Borrower or
           Group Company is treated as a single employer within the meaning of
           Section 414(b), (c), (m) or (o) of the Code or Section 4001(b) of
           ERISA;


           "EVENT OF DEFAULT" means any event or circumstance specified as such
           in Clause 23;


           "EXISTING INVERESK FACILITIES" means those facilities made available
           to the Parent pursuant to a Facilities Agreement dated 4 September
           1999;


           "FACILITY" means any Series 1 Term Facility, any Series 2 Term
           Facility, the Capital Expenditure Facility, or the Working Capital
           Facility;


           "FACILITY OFFICE" means the office or offices notified by a Lender to
           the Agent in writing on or before the date it becomes a Lender (or,
           following that date, by not less than five Business Days' written
           notice) as the office or offices through which it will perform its
           obligations under this Agreement;


           "FFE AMOUNT" means that amount of Canadian Dollars or Sterling, as
           appropriate, required in terms of the FFE Contract to purchase the
           relevant amount of US Dollars;


           "FFE CONTRACT" means any forward foreign exchange contract entered
           into pursuant to Clause 22.1.3(p);


           "FINAL REPAYMENT DATE" means:

           (a)       in respect of each Series 1 Term Facility, 31 December
                     2007;

           (b)       in respect of each Series 2 Term Facility, 31 December
                     2008;

           (c)       in respect of the Capital Expenditure Facility, 31 December
                     2007;

           (d)       in respect of the Working Capital Facility 31 December
                     2007;


           "FINANCE DOCUMENT" means this Agreement, any Fee Letter, any
           Accession Letter, each Security Document, the Inter Creditor
           Agreement any Hedging Agreement and any other document designated as
           such by the Agent and the Parent;


           "FINANCE LEASE" means any lease, hire agreement, credit sale
           agreement, purchase agreement, conditional sale agreement or
           instalment sale and purchase agreement


                                       7
   15
           which should be treated in accordance with Applicable Accounting
           Principles as a finance lease or in the same way as a finance lease;


           "FINANCE PARTY" means the Agent, the Security Trustee, the Arranger,
           a Lender, a Working Capital Bank or the Working Capital Bank;


           "FINANCE PERIOD" means the period from the date of this Agreement
           until the first date on which none of the Finance Parties or the
           Obligors has actual or contingent liabilities or obligations under
           any of the Finance Documents;

           "FINANCIAL COVENANTS" means the covenants contained in Clause 21;


           "FINANCIAL INDEBTEDNESS" means any indebtedness for or in respect of:

           (a)       monies borrowed;

           (b)       any amount raised by acceptance under any acceptance credit
                     facility;

           (c)       any amount raised pursuant to any note purchase facility or
                     the issue of bonds, notes, debentures, loan stock or any
                     similar instrument;

           (d)       the amount of any liability in respect of any lease or hire
                     purchase contract which would, in accordance with GAAP, be
                     treated as a Finance Lease;

           (e)       receivables sold or discounted (other than any receivables
                     to the extent they are sold on a non-recourse basis);

           (f)       any amount raised under any other transaction (including
                     any forward sale or purchase agreement) having the
                     commercial effect of a borrowing;

           (g)       any derivative transaction entered into in connection with
                     protection against or benefit from fluctuation in any rate
                     or price (and, when calculating the value of any derivative
                     transaction at any time, only the cost on termination or
                     closing out on the basis of the then marked to market value
                     of the relevant derivative transaction shall be taken into
                     account);

           (h)       any counter-indemnity obligation in respect of a guarantee,
                     indemnity, bond, standby or documentary letter of credit or
                     any other instrument issued by a bank or financial
                     institution; and

           (i)       the amount of any liability in respect of any guarantee or
                     indemnity for any of the items referred to in paragraph (a)
                     to (h) above;


           but without double counting in any case;


           "FULL GROUP SECURITY" means in respect of an Obligor a guarantee in
           favour of the Security Trustee as it or the Agent may require (in
           each case in form and substance satisfactory to the Security Trustee)
           from the relevant Obligor in respect of the obligations of each
           Obligor to the Finance Parties under the Finance Documents, security
           documentation constituting such fixed and/or floating security
           interests in respect of the relevant Obligor's assets as the Agent or
           the Security Trustee may reasonably require and such other supporting
           documents as the Agent or the Security Trustee may reasonably
           require;


                                       8
   16
           "GAAP" means in relation to a company incorporated in any
           jurisdiction generally accepted accounting policies in the relevant
           jurisdiction;


           "GROUP" means the Parent and its Subsidiaries for the time being and
           "GROUP COMPANY" or "MEMBER OF THE Group" means any one of them (and,
           for the avoidance of any doubt, no company shall be a member of the
           Group until it becomes a Subsidiary of a member of the Group);


           "GUARANTEE" means any guarantee, bond, indemnity, letter of credit,
           documentary or other credit, or other obligation to pay, purchase,
           provide funds to cover, or ensure against financial loss in respect
           of Financial Indebtedness of any other person and any obligation to
           invest in, make advances to or maintain the solvency or financial
           condition of any other person in connection with or by reference to
           the Financial Indebtedness of that person;


           "GUARANTEE REQUEST" means a request substantially in the form set out
           in Schedule 13;


           "GUARANTEED AMOUNT" means in relation to a Bank Guarantee denominated
           in Sterling, the maximum aggregate amount of the actual and
           contingent liabilities of the Working Capital Bank under that Bank
           Guarantee at the relevant time and in relation to a Bank Guarantee
           denominated in the Optional Currency, the Sterling Equivalent of the
           maximum aggregate amount of the actual and contingent liabilities of
           the Working Capital Bank under that Bank Guarantee at the relevant
           time;


           "GUARANTOR" means an Original Guarantor or an Additional Guarantor,
           unless it has ceased to be a Guarantor in accordance with Clause
           25.6;


           "HEDGING AGREEMENTS" means any agreements entered into for the
           purpose of managing or hedging currency and/or interest rate
           obligations;


           "HOLDING COMPANY" means, in relation to a company or corporation, any
           other company or corporation in respect of which it is a Subsidiary;


           "INSOLVENCY EVENT" means, subject to the terms of Clause 3.6.3, any
           of the events specified in any of Clauses 23.6-23.12 (inclusive);


           "INSURANCE REPORT" means the report in agreed form prepared by Marsh
           UK Ltd and Marsh Inc;


           "INTELLECTUAL PROPERTY RIGHTS" means all know-how, patents, patent
           applications, trade marks, community trade marks, service marks,
           trade names, brand names, business names, registered designs,
           copyright and all other industrial and intellectual property rights
           and any interests (including by way of licence) in any of the
           foregoing (in each case whether registered or not and including all
           applications for the same);


           "INTER CREDITOR DEED" means the inter creditor agreement in the
           agreed form between the Finance Parties, the Parent certain Group
           Companies and the Investors (as defined therein);


                                       9
   17
           "INTEREST PERIOD" means, in relation to a Loan, each period
           determined in accordance with Clause 10 and, in relation to an Unpaid
           Sum, each period determined in accordance with Clause 9.1.3;


           "INTRA GROUP TRANSFER" means the proposed transfer by Target Company
           to Canada Holdco of the entire issued share capital of Clintrials Bio
           Research Limited;


           "INVESTMENT AGREEMENT" means the agreement so entitled dated on or
           around the date of this Agreement between inter alia the Parent,
           Walter Nimmo and others as Existing Managers, the ESOP Trustees (as
           defined therein) and the Investors (as defined therein);


           "ISSUE DATE" means in relation to a Bank Guarantee the date on which
           it is issued pursuant to the terms thereof;


           "KEYMAN INSURANCE" means the keyman life assurance policies to be
           maintained by the Parent in respect of the death, critical illness or
           disability of the persons specified in Schedule 15;


           "LEGAL REPORT" means the report in agreed form by Clifford Chance;


           "LENDER" means:

           (a)       any Original Lender; and

           (b)       any bank or financial institution which has become a Party
                     in accordance with Clause 24,


           which in each case has not ceased to be a Party in accordance with
           the terms of this Agreement;


           "LENDER INDEMNITY" means in relation to a Lender, the indemnity given
           by that Lender to the Working Capital Bank under Clause 6.9 and
           "LENDER INDEMNITIES" shall be construed accordingly;


           "LIBOR" means, in relation to any amount for which the rate is to be
           determined:

           (a)       the applicable Screen Rate; or

           (b)       (if no Screen Rate is available for the relevant currency
                     for the Interest Period of that Loan) the arithmetic mean
                     of the rates (rounded upwards to four decimal places) as
                     supplied to the Agent at its request quoted by the
                     Reference Banks to leading banks in the London interbank
                     market,


           as of the Specified Time on the Quotation Day for the offering of
           deposits in the relevant currency and for a period comparable to the
           period for which such rate is to be determined;


           "LISTING" means the admission to the Official List of London Stock
           Exchange PLC of any shares of any member of the Group or the granting
           of permission for any such shares to be dealt in or on any recognised
           investment exchange (within the meaning of Section 207 of the
           Financial Services Act 1986) or any other market for the public
           trading of securities in any country or a reverse takeover (within
           the meaning contained in the publication by the UK listing authority
           entitled "The


                                       10
   18
           Listing Rules" current at the date of this Agreement) by any member
           of the Group of another company whose shares are already the subject
           of a Listing;


           "LOAN" means a Series 1 Term Facility Loan, a Series 2 Term Facility
           Loan or a Capital Expenditure Facility Loan;


           "LOAN STOCK" means the L71,771,981 Unsecured Subordinated Loan Stock
           2008 constituted by the Loan Stock Instrument or, as the case may be,
           the principal amounts represented by them and for the time being
           issued and outstanding;


           "LOAN STOCK INSTRUMENT" means the loan stock instrument dated 20
           September 1999 by the Parent as supplemented by the supplemental
           instrument in the agreed form to be granted by the Parent;


           "MAJORITY LENDERS" means:

           (a)       if there are no Loans, Working Capital Loans or
                     Utilisations then outstanding, a Lender or Lenders whose
                     Commitments aggregate more than 662/3% of the Total
                     Commitments (or, if the Total Commitments have been reduced
                     to zero, aggregated more than 662/3% of the Total
                     Commitments immediately prior to the reduction); or

           (b)       at any other time, a Lender or Lenders whose participations
                     in the Loans, Working Capital Loans and Utilisations then
                     outstanding aggregate more than 662/3% of all the Loans,
                     Working Capital Loans and Utilisations then outstanding;


           "MANAGEMENT ACCOUNTS" means:

           (a)       the management accounts for each Group Company for each
                     Management Accounting Period in the agreed form which shall
                     include a profit and loss account for the Management
                     Accounting Period and the financial year to date;

           (b)       a balance sheet as at the last day of the relevant
                     Management Accounting Period;

           (c)       a cash flow for the Management Accounting Period and
                     financial year to date; and

           (d)       key performance indicators for each Management Accounting
                     Period, together with a commentary by the finance director
                     of the Parent, in particular comparing actual performance
                     to relevant Operating Budget and providing a review of the
                     outstanding order book;


           "MANAGEMENT ACCOUNTING PERIOD" means each period incorporating all or
           substantially all of each calendar month and (unless otherwise agreed
           by the Agent) not being less than four nor more than five weeks in
           duration;


           "MANAGEMENT TEAM" means all and each of Stewart G Leslie, Nick
           Thornton, Dr Walter S Nimmo, Mike Ankcorn, Paul Bancroft, Dr Ian P
           Sword, and/or such other persons as shall be agreed between the Agent
           and the Parent;


           "MANDATORY COSTS" means the percentage rate per annum calculated by
           the Agent in accordance with Schedule 6;


                                       11
   19
           "MANDATORY PREPAYMENT EVENT" means any event set out in Clauses 8.1
           or 8.2;

           "MARGIN" means subject to the terms of this Agreement:

           (a)       in respect of a Series 1 Term Facility Loan, 2.25% per
                     annum;

           (b)       in respect of a Series 2 Term Facility Loan, 2.75% per
                     annum;

           (c)       in respect of a Capital Expenditure Facility Loan, 2.75%
                     per annum; and

           (d)       in respect of the Working Capital Facility, 2.25% per
                     annum;


           "MARKET REPORT" means the report in the agreed form dated on or
           around the date hereof by Technomark Consulting Services in relation
           to the business of the Target Group;


           "MATERIAL ADVERSE EFFECT" means an event or matter:

           (a)       having, or reasonably likely to have a material adverse
                     effect on the financial condition, assets, revenues of the
                     Group taken as a whole; or

           (b)       having a material adverse effect on the ability of the
                     Parent or any Group Company either to perform in a timely
                     manner all or any of its payment obligations under any of
                     the Finance Documents or to comply with the Financial
                     Covenants; or

           (c)       (where the context so admits) resulting in all or any of
                     the Security Documents not providing the Security Trustee
                     (on behalf of the Lenders) with effective enforceable
                     security over the assets expressed to be charged by the
                     relevant Security Document or Security Documents to an
                     extent reasonably considered to be material by the Majority
                     Lenders;


           "MATERIAL COMPANY" means a Group Member which is trading and has net
           assets (ignoring intra group assets and liabilities) in excess of
           L500,000 (all the companies listed in Part 1 of Schedule 16 being the
           Material Companies as at the date of execution of this Agreement);


           "MERGER" means the merger of US Newco with the Target, as described
           in the Merger Agreement;


           "MERGER AGREEMENT" means the Agreement and Plan of Merger dated on or
           around the date hereof between the Parent, US Newco and the Target;


           "MERGER DOCUMENTS" means the Merger Agreement, the Stockholders
           Agreement and all other documents executed in connection with either
           of those documents;


           "MERGER RELATED UNDERTAKINGS" means those undertakings in Clauses
           22.4.1;


           "MINIMUM CONDITION" shall have the meaning given thereto in the
           Merger Agreement;


           "MONTH" means a period starting on one day in a calendar month and
           ending on the numerically corresponding day in the next calendar
           month, except that:


                                       12
   20
           (a)       (subject to paragraph (c) below) if the numerically
                     corresponding day is not a Business Day, that period shall
                     end on the next Business Day in that calendar month in
                     which that period is to end if there is one, or if there is
                     not, on the immediately preceding Business Day;

           (b)       if there is no numerically corresponding day in the
                     calendar month in which that period is to end, that period
                     shall end on the last Business Day in that calendar month;
                     and

           (c)       if an Interest Period begins on the last Business Day of a
                     calendar month, that Interest Period shall end on the last
                     Business Day in the calendar month in which that Interest
                     Period is to end.


           The above rules will only apply to the last Month of any period.


           "MULTIEMPLOYER PLAN" means a "multiemployer plan" as defined in
           Section 4001(a)(3) of ERISA to which any Borrower, any Group Company
           or any ERISA Affiliate is making or is accruing an obligation to
           make, contributions within the preceding six years;


           "NET PROCEEDS" means the consideration received by any Group Company
           in respect of a disposal which is not a Permitted Disposal of any
           fixed asset or interest therein after deducting any Taxation
           resulting from such disposal and costs reasonably incurred by such
           Group Company in making the disposal;


           "OBLIGOR" means a Borrower or a Guarantor;


           "OPERATING BUDGET" means:

           (a)       in relation to the period starting not later than the date
                     of this Agreement and ending on the production of the first
                     Operating Budget pursuant to Clause 20.1(c) the Business
                     Plan; and

           (b)       in relation to each successive 12 month period thereafter:-

                     (i)        a projected balance sheet;

                     (ii)       a projected profit and loss account;

                     (iii)      a projected cash flow statement;

                     (iv)       a projected capital expenditure budget; and

                     (v)        projected calculations relating to each
                                Financial Covenant,


           on a 12 month and Management Accounting Period basis together with a
           commentary from the finance director of the Parent drawing on the
           previous period's performance and forecast market conditions;


           "OPTIONAL CURRENCY" means in respect of the Working Capital Facility
           Canadian Dollars or any other currency approved by the Agent in its
           absolute discretion;


                                       13
   21
           "ORIGINAL BORROWER" means:

           (a)       in respect of each of the Parent Series 1 Refinancing Term
                     Facility, the Parent Series 2 Refinancing Term Facility,
                     the Parent Series 1 Acquisition Term Facility and the
                     Parent Series 2 Acquisition Term Facility, the Parent;

           (b)       in respect of the Canada Holdco Series 1 Acquisition Term
                     Facility and the Canada Holdco Series 2 Acquisition Term
                     Facility, Canada Holdco;

           (c)       in respect of the Capital Expenditure Facility, Canada
                     Holdco and Clintrials BioResearches Limited; and;

           (d)       in respect of the Working Capital Facility, the Parent and
                     Canada Holdco;


           "ORIGINAL FINANCIAL STATEMENTS" means:

           (a)       in relation to the Parent, the audited consolidated
                     financial statements of the Group for the 24 week period
                     ended 26 December 1999; and

           (b)       in relation to each Original Obligor other than the Parent,
                     its audited financial statements (if any) for the period
                     ended 26 December 1999;


           "ORIGINAL GUARANTOR" means the Parent, Inveresk Research Holdings
           Ltd, Inveresk Research International Ltd, Inveresk Clinical Research
           Ltd and those Group Members listed as such in Schedule 1;


           "ORIGINAL OBLIGOR" means an Original Borrower or an Original
           Guarantor;


           "OVERSEAS COMPANIES" means those Group Companies listed as such in
           Schedule 16 Part 3;


           "PARENT SERIES 1 ACQUISITION TERM FACILITY" means the term loan
           facility made available under this Agreement and described in Clause
           2.1.1(c);


           "PARENT SERIES 1 ACQUISITION TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender, the amount in the Base
                     Currency set under its name opposite the words "Parent
                     Series 1 Acquisition Term Facility Commitment" in Schedule
                     2 (or the relevant Re-denominated Commitment Amount) and
                     the amount of any other Parent Series 1 Acquisition Term
                     Facility Commitment transferred to it under this Agreement;
                     and

           (b)       in relation to any other Lender, the amount is the Base
                     Currency of any Parent Series 1 Acquisition Term Facility
                     Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "PARENT SERIES 1 ACQUISITION TERM FACILITY LOAN" means a loan made or
           to be made under the Parent Series 1 Acquisition Term Facility or the
           principal amount outstanding for the time being of that loan;


                                       14
   22
           "PARENT SERIES 1 REFINANCING TERM FACILITY" means the term loan
           facility made available under this Agreement and described in Clause
           2.1.1(a);


           "PARENT SERIES 1 REFINANCING TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender, the amount in the Base
                     Currency set under its name opposite the words "Parent
                     Series 1 Refinancing Term Facility Commitment" in Schedule
                     2 (or the relevant Re-denominated Commitment Amount)and the
                     amount of any other Parent Series 1 Refinancing Term
                     Facility Commitment transferred to it under this Agreement;
                     and

           (b)       in relation to any other Lender, the amount is the Base
                     Currency of any Parent Series 1 Refinancing Term Facility
                     Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "PARENT SERIES 1 REFINANCING TERM FACILITY LOAN" means a loan made or
           to be made under the Parent Series 1 Acquisition Term Facility or the
           principal amount outstanding for the time being of that loan;


           "PARENT SERIES 2 ACQUISITION TERM FACILITY" means the term loan
           facility made available under this Agreement and described in Clause
           2.1.1(d);


           "PARENT SERIES 2 ACQUISITION TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender the amount in the Base
                     Currency set under its name opposite the words "Parent
                     Series 2 Acquisition Term Facility Commitment" in Schedule
                     2 and the amount of any other Parent Series 2 Acquisition
                     Term Facility Commitment transferred to it under this
                     Agreement; and


                                       15
   23
           (b)       in relation to any other Lender, the amount is the Base
                     Currency of any Parent Series 2 Acquisition Term Facility
                     Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "PARENT SERIES 2 ACQUISITION TERM FACILITY LOAN" means a loan made or
           to be made under the Parent Series 2 Acquisition Term Facility or the
           principal amount outstanding for the time being of that loan;


           "PARENT SERIES 2 REFINANCING TERM FACILITY" means the term loan
           facility made available under this Agreement and described in Clause
           2.1.1(b);


           "PARENT SERIES 2 REFINANCING TERM FACILITY COMMITMENT" means:

           (a)       in relation to an Original Lender the amount in the Base
                     Currency set under its name opposite the words "Parent
                     Series 1 Refinancing Term Facility Commitment" in Schedule
                     2 and the amount of any other Parent Series 2 Refinancing
                     Term Facility Commitment transferred to it under this
                     Agreement; and

           (b)       in relation to any other Lender, the amount is the Base
                     Currency of any Parent Series 2 Refinancing Term Facility
                     Commitment transferred to it under this Agreement;


           to the extent not cancelled, reduced or transferred by it under this
           Agreement;


           "PARENT SERIES 2 REFINANCING TERM FACILITY LOAN" means a loan made or
           to be made under the Parent Series 2 Refinancing Term Facility or the
           principal amount outstanding for the time being of that loan;


           "PARTY" means a party to this Agreement and includes its successors
           in title, permitted assignees and permitted transferees;


           "PBGC" means the Pension Benefit Guaranty Corporation or any
successor agency.


           "PENSION PLAN" means any Employee Benefit Plan, other than a
           Multiemployer Plan, which is subject to the provisions of Title IV or
           ERISA or Section 412 of the Code and which:

           (a)       is maintained for employers of any Borrower, Group Company
                     or ERISA Affiliate; or

           (b)       has at any time within the preceding six years been
                     maintained for the employees of any Borrower, Group Company
                     or current or former ERISA Affiliate.


           "PENSIONS REPORT" means the report in agreed form prepared by William
M Mercer Inc and William M Mercer Ltd;


           "PERMITTED APPLICATION" means in respect of any Net Proceeds either:

           (a)       the acquisition of a replacement fixed asset of the same or
                     a similar type and of comparable or superior value and
                     quality; or

           (b)       the acquisition of a fixed asset the commercial purpose and
                     effect of which is to replace or improve upon the
                     commercial purpose and effect of the fixed asset disposed
                     of;


           "PERMITTED DISPOSAL" means:

                     (i)        any sale or disposal of assets expressed in any
                                Security Documents to be charged by way of
                                floating charge only and which is a sale or
                                disposal in the ordinary course of trading
                                activities and for market-value on an
                                arms-length basis for consideration payable in
                                cash on normal commercial terms other than any
                                sale or other disposal of any heritable, real or
                                leasehold property;

                     (ii)       any sale or disposal of assets expressed in any
                                Security Documents to be charged by way of
                                floating charge only and which are obsolete or
                                redundant and have a nominal or scrap value
                                only;

                     (iii)      a sale or disposal to an Obligor or a disposal
                                by a Group Company which is not an Obligor to
                                another Group Company


                                       16
   24
                                which is an Obligor provided the transferee has
                                granted Full Group Security;

                     (iv)       any disposal on arm's length terms where the
                                aggregate value of the assets the subject of the
                                disposal by Group Companies in any 12 month
                                period other than in accordance with paragraphs
                                (i) to (iii) above in any financial year does
                                not exceed L250,000 (based on the higher of book
                                value or consideration);


           Provided in each case that any monies thereby received by the member
           of the Group making the sale or disposition are credited to an
           account with the Agent but for the avoidance of doubt such monies
           will not be treated as Unapplied Net Proceeds;


           "PERMITTED FINANCIAL INDEBTEDNESS" means Financial Indebtedness:

           (a)       of the Group from time to time under this Agreement;

           (b)       under the Loan Stock Instrument;

           (c)       arising between Group Companies where each has granted Full
                     Group Security;

           (d)       arising under Hedging Agreements entered into by any Group
                     Company;

           (e)       under any lease or hire purchase contract which would in
                     accordance with GAAP be treated as a Finance Lease in terms
                     of which assets with an aggregate outstanding capital value
                     not exceeding US$3,000,000 (or such greater amount as the
                     Agent may from time to time agree) are hired or leased;

           (f)       of Clinical Group Members owed to an Approved Financier in
                     an aggregate principal amount not exceeding US$5,000,000;

           (g)       the letter of credit referred to in Clause 22.1.10 (subject
                     always to the Parent's compliance with its obligations
                     under that Clause);

           (h)       of Clinical Group Members to Bank of America (subject
                     always to the Parent's compliance with its obligations
                     under Clause 22.1.9);

           (i)       approved in writing by the Agent;


           "PERMITTED SECURITY INTEREST" means:-

           (a)       rights of retention of title and liens which are implied by
                     law or custom of trade or are incorporated in the standard
                     terms of contract of another contracting party and which
                     arise in any such case in the ordinary course of trade of
                     any Group Company;

           (b)       any liens and rights of set off arising by operation of law
                     in the ordinary course of trading of any Group Company;

           (c)       any Security which the Agent has at any time in writing
                     agreed shall be a Permitted Security Interest;

           (d)       any Security created under the Finance Documents;


                                       17
   25
           (e)       any Security created by any court order in favour of the
                     plaintiff or the defendant in any action as security for
                     costs or expenses provided the relevant Group Company is
                     pursuing or defending such action in the bona fide
                     interests of that Group Company and provided further that
                     such action is not an Event of Default or Default;

           (f)       any Security other than otherwise permitted under this
                     Agreement securing Financial Indebtedness in an aggregate
                     principal amount not exceeding L250,000;

           (g)       any Security over credit balances and bank accounts of
                     members of the Clinical Group with an Approved Financier
                     created in order to facilitate the operation of such bank
                     accounts and other bank accounts of such members of the
                     Clinical Group with such Approved Financier on a net
                     balance basis with credit balances and debit balances on
                     the various accounts being netted off for interest
                     purposes;

           (h)       any Security held by an Approved Financier over assets of
                     members of the Clinical Group;

           (i)       any Security held by Bank of America in respect of assets
                     of Clinical Group Members and any Security held by The
                     Royal Bank of Canada in respect of assets of Clintrials
                     BioResearches Limited (subject always to the Parent's
                     compliance with its obligations under Clause 22.1.9);


           "PRIMARY DEFAULT" means:-

           (a)       the occurrence of an Insolvency Event;

           (b)       a breach of any Merger Related Undertaking;

           (c)       an Event of Default in terms of Clause 23.17;

           (d)       a breach of Clause 22.1.3(p);


           "PRIMARY WARRANTIES" means those representations and warranties in
           Clauses 19.1, 19.2, and 19.3;


           "PROPERTY" means Elphinstone Research Centre, Tranent, East Lothian;
           The Origo Centre, Riccarton, Midlothian; and 46 Millar Crescent,
           Edinburgh;


           "QUALIFYING LENDER" has the meaning given to it in Clause 13;


           "QUOTATION DAY" means, in relation to any period for which an
           interest rate is to be determined, two Business Days before the first
           day of that period unless market practice differs in the Relevant
           Interbank Market, in which case the Quotation Day will be determined
           by the Agent in accordance with market practice in the Relevant
           Interbank Market (and if quotations would normally be given by
           leading banks in the Relevant Interbank Market on more than one day,
           the Quotation Day will be the last of those days);


           "RE-DENOMINATED COMMITMENT AMOUNT" bears the meaning given to it in
           Clause 5.5;


           "RE-DENOMINATION DATE" bears the meaning given to it in Clause 5.3 ;


                                       18
   26
           "RE-DENOMINATION PERIOD" means the period of one month from Closing;


           "REFERENCE BANKS" means the principal London offices of such banks as
           may be appointed by the Agent in consultation with the Parent;


           "RELEVANT DISPOSAL" means a disposal of fixed assets or groups of
           fixed assets by a member of the Ringfenced Group the net proceeds of
           which are at least L500,000, not being a disposal from one Obligor to
           another;


           "RELEVANT INTERBANK MARKET" means the London interbank market;


           "REPAYMENT DATE" means a Series 1 Term Facilities Repayment Date, a
           Series 2 Term Facilities Repayment Date or a Capital Expenditure
           Facility Repayment Date as the context may require;


           "REPAYMENT INSTALMENT" means a Series 1 Term Facility Repayment
           Instalment, a Series 2 Term Facility Repayment Instalment or a
           Capital Expenditure Facility Repayment Instalment as the context may
           require;


           "REPEATING REPRESENTATIONS" means each of the representations given
           pursuant to Clause 19 save for those in Clauses 19.5.2 (in respect of
           a Default only), 19.6, 19.10, 19.11, 19.12, 19.13, 19.17, 19.20,
           19.21, 19.22 and 19.23;


           "REPORTS" means the Accountants Report, the Environmental Report, the
           Insurance Report, the Pensions Report, Legal Report, Market Report
           and Canadian Report on Title;


           "RESERVATIONS" means the principle that equitable remedies are
           remedies which may be granted or refused at the discretion of the
           court and damages may be regarded as an adequate remedy, the
           limitation of enforcement by laws relating to bankruptcy, insolvency,
           liquidation, reorganisation, court schemes, moratoria, administration
           and other laws generally affecting the rights of creditors, the
           time-barring of claims under the Limitation Acts (and similar
           legislation), the possibility that an undertaking to assume liability
           for or to indemnify a person against non-payment of stamp duty may be
           void, the fact that a court may refuse to give effect to a purported
           contractual obligation to pay costs imposed upon another party in
           respect of the costs of any unsuccessful litigation brought against
           that party or may not award by way of costs all of the expenditure
           incurred by a successful litigant in proceedings brought before that
           court, or that a court may stay proceedings if concurrent proceedings
           based on the same grounds and between the same parties have
           previously been brought before another court, that a court may not
           give effect to the provisions of Clause 35 (or any similar provision
           in another Finance Document) and that interest at a default rate on
           overdue amounts may be a penalty and not recoverable;


           "RESIGNATION LETTER" means a letter substantially in the form set out
           in Schedule 9;


           "RINGFENCED GROUP" means the Group other than the Clinical Group
           Members and "RINGFENCED GROUP MEMBERS" shall be construed
           accordingly;


           "SALE" means a sale of all or substantially all of the issued share
           capital of the Parent or a sale of all or substantially all of the
           business and assets of the Group;


                                       19
   27
           "SCREEN RATE" means the British Bankers' Association Interest
           Settlement Rate for dollars for the relevant period displayed on the
           appropriate page of the Reuters screen. If the agreed page is
           replaced or service ceases to be available, the Agent may specify
           another page or service displaying the appropriate rate after
           consultation with the Parent and the Lenders;


           "SECOND STAGE SECURITY" means:

           (a)       pledge/charge by Canada Holdco in respect of the entire
                     issued stock of Target;

           (b)       Guarantor Accession Letter by Clintrials BioResearches
                     Limited;

           (c)       deed of hypothecation by Clintrials BioResearches Limited;

           (d)       Canadian Financial Assistance Documents;


           each in the form agreed by the parties acting reasonably;


           "SECURITY" means a mortgage, charge, pledge, lien, floating charge,
           standard security, debenture, hypothec or other security interest
           securing any obligation of any person or any other agreement or
           arrangement having a similar effect;


           "SECURITY ACCOUNT" means such account (bearing interest at an
           appropriate market rate) with the Agent in the name of the relevant
           Group Company into which any sums are to be paid in accordance with
           this Agreement and which is subject to such security or other payment
           or blocking or designation arrangements as the Agent may reasonably
           require;


           "SECURITY DOCUMENTS" means the Security Documents to be granted by
           each Obligor to the Security Trustee and listed in Schedule 3 and all
           other documents from time to time creating, evidencing or granting
           Security in favour of the Finance Parties (or any of them) and
           granted by the Obligor as security for the obligations of the
           Obligors to the Lenders from time to time under any of the Finance
           Documents and "Security Document" shall be construed accordingly;


           "SECURITY TRUSTEE" means Bear Stearns Corporate Lending Inc in its
           capacity as security trustee of the Security Documents under and in
           terms of Clause 27.17 and its successors and assigns in that
           capacity;


           "SELECTION NOTICE" means a notice substantially in the form set out
           in Schedule 5 given in accordance with Clause 10 in relation to a
           Facility;


           "SERIES 1 TERM FACILITIES" means each and all of the Parent Series 1
           Refinancing Term Facility, the Parent Series 1 Acquisition Term
           Facility and the Canada Holdco Series 1 Acquisition Term Facility;


           "SERIES 1 TERM FACILITY LOAN" means a loan made or to be made under
           any Series 1 Term Facility or the principal amount outstanding for
           the time being of that loan;


           "SERIES 2 TERM FACILITIES" means each and all of the Parent Series 2
           Refinancing Term Facility, the Parent Series 2 Acquisition Term
           Facility and the Canada Holdco Series 2 Acquisition Term Facility;


                                       20
   28
           "SERIES 2 TERM FACILITY LOAN" means a loan made or to be made under
           any Series 2 Term Facility or the principal amount outstanding for
           the time being of that loan;


           "SHAREHOLDER PAYMENT" means any payment (whether in cash or
           otherwise) by the Parent in respect of:

           (a)       Distributions in respect of its shares; or

           (b)       redemption of any of its shares or the Loan Stock; or

           (c)       interest on the Loan Stock;


           "SPECIFIED PURPOSE" means in respect of any particular Facility, the
           purpose of such Facility as specified in Clause 3.1;


           "SPECIFIED TIME" means a time determined in accordance with Schedule
           11;


           "STERLING" and "L" means the lawful currency of the United Kingdom;


           "STERLING EQUIVALENT" means in respect of currency borrowings or
           utilisations in the Optional Currency under the Working Capital
           Facility the amount of Sterling required to purchase the relevant
           currency at the Working Capital Bank's spot rate of exchange on the
           applicable day at such time as the Working Capital Bank may select in
           accordance with its normal market practice for currency borrowings
           under working capital facilities;


           "STOCKHOLDERS AGREEMENT" means the stockholders agreement dated on or
           around the date hereof between inter alia the Parent and US Newco;


           "SUBSIDIARY" means a subsidiary within the meaning of section 736 of
           the Companies Act 1985;


           "SURPLUS" means that amount in excess of US$2,000,000 by which the
           cash flow covenant referred to in Clause 21.1.4 is exceeded on any
           covenant test date;


           "TARGET" means Clintrials Research Inc;


           "TARGET ACCOUNTS" means the draft financial statements of each Target
           Group Company for the financial year ended 31 December 2000 together
           with all statements, notes, directors and auditors reports annexed to
           or incorporated in them;


           "TARGET GROUP" means the Target and its Subsidiaries and "TARGET
           GROUP COMPANY" means any of them;


           "TARGET GROUP US BANK INDEBTEDNESS" means the indebtedness as at
           today's date of Target Group Companies to Bank of America;


           "TARGET MANAGEMENT ACCOUNTS" means the individual and consolidated
           management accounts of the Target Group for the period to 31 December
           2000;


           "TARGET STOCK" means the Company Common Stock, as defined in the
           Merger Agreement;


                                       21
   29

        "TAX" means any tax, levy, impost, duty or other charge or withholding
        of a similar nature (including any penalty or interest payable in
        connection with any failure to pay or any delay in paying any of the
        same);


        "TAXES ACT" means the Income and Corporation Taxes Act 1988;


        "TENDER OFFER" means the Offer, as defined in the Merger Agreement;


        "TERM FACILITY" means any of the Series 1 Term Facilities or the Series
        2 Term Facilities;


        "TERMINATION EVENT" means:

        (a)     a "Reportable Event" described in Section 4043 of ERISA; or

        (b)     the withdrawal of any Borrower, Group Company or any ERISA
                Affiliate from a Pension Plan during a plan year in which it was
                a "substantial employer" as defined in Section 4001(a)(2) of
                ERISA; or

        (c)     the termination of a Pension Plan, the filing of a notice of
                intent to terminate a Pension Plan or the treatment of a Pension
                Plan amendment as a termination under Section 4041 of ERISA; or

        (d)     the institution of proceedings to terminate, or the appointment
                of a trustee with respect to, any Pension Plan by the PBGC; or

        (e)     any other event or condition which would constitute grounds
                under Section 4042(a) of ERISA for the termination of, or the
                appointment of a trustee to administer, any Pension Plan; or

        (f)     the partial or complete withdrawal of any Borrower, Group
                Company or ERISA Affiliate from a Multiemployer Plan; or

        (g)     the imposition of a Lien pursuant to Section 412 of the Code or
                Section 302 of ERISA; or

        (h)     any event or condition which results in the reorganisation or
                insolvency of a Multiemployer Plan under Sections 4241 or 4245
                or ERISA; or

        (i)     any event or condition which results in the termination of a
                Multiemployer Plan under Section 4041A of ERISA or the
                institution by PBGC of proceedings to terminate a Multiemployer
                Plan under Section 4042 of ERISA;


        "THIRD STAGE SECURITY" means a pledge/charge by Canada Holdco in respect
        of the entire issued share capital of Clintrials BioResearches Limited
        in the agreed form;


        "TOTAL COMMITMENTS" means the aggregate of the Canada Holdco Series 1
        Acquisition Term Facility Commitments, Canada Holdco Series 2
        Acquisition Term Facility Commitments, Parent Series 1 Acquisition Term
        Facility Commitments, Parent Series 2 Acquisition Term Facility
        Commitments, Parent Series 1 Refinancing Term Facility Commitments,
        Parent Series 2 Refinancing Term Facility Commitments the Total Capital
        Expenditure Facility Commitments and the Total Working Capital Facility
        Commitments;


                                       22
   30
        "TOTAL CAPITAL EXPENDITURE FACILITY COMMITMENTS" means the aggregate of
        the Capital Expenditure Facility Commitments being C$15,300,000 at the
        date of this Agreement;


        "TOTAL WORKING CAPITAL FACILITY COMMITMENTS" means the aggregate of the
        Working Capital Facility Commitments being L6,000,000 at the date of
        this Agreement;


        "TRANSACTION DOCUMENTS" means the Finance Documents, the Merger
        Documents, the Tender Offer and the Equity Documents;


        "TRANSFER CERTIFICATE" means a certificate substantially in the form set
        out in Schedule 7 or any other form agreed between the Agent and the
        Parent;


        "TRANSFER DATE" means, in relation to a transfer, the later of:

        (a)     the proposed Transfer Date specified in the Transfer
                Certificate; and

        (b)     the date on which the Agent executes the Transfer Certificate;


        "UNAPPLIED NET PROCEEDS" means in respect of a Relevant Disposal means
        those net proceeds of such Relevant Disposal which, as at the end of the
        period of 6 months after the date of such relevant disposal, have not
        been applied in a Permitted Application;


        "UNPAID SUM" means any sum due and payable but unpaid by an Obligor
        under the Finance Documents;


        "US DOLLARS" and "US$" means the lawful currency of the United States of
        America;


        "US NEWCO" means Indigo Acquisition Corp;


        "UTILISATION" means a utilisation of a Facility;


        "UTILISATION DATE" means the date of a Utilisation, being the date on
        which the relevant Loan or Utilisation of the Working Capital Facility
        is to be made;


        "UTILISATION REQUEST" means a notice substantially in the form set out
        in Schedule 4;


        "VAT" means value added tax as provided for in the Value Added Tax Act
        1994 and any other tax of a similar nature;


        "WORKING CAPITAL AVAILABLE AMOUNT" means subject to the Working Capital
        Facility Limit at any time the difference between the Total Working
        Capital Facility Commitments of all Working Capital Banks and the
        Working Capital Outstandings at that time;


        "WORKING CAPITAL FACILITY" means the working capital facility made
        available under this Agreement and described in Clause 2.1.3;


                                       23
   31
        "WORKING CAPITAL FACILITY COMMITMENT" means:

        (a)     in relation to an Original Lender, the amount, if any, set under
                its name opposite the words "Working Capital Facility
                Commitment" in Schedule 2 and the amount of any other Working
                Capital Facility Commitment transferred to it under this
                Agreement; and

        (b)     in relation to any other Lender, the amount, if any, of any
                Working Capital Facility Commitment transferred to it under this
                Agreement,


        to the extent not cancelled, reduced or transferred by it under this
        Agreement;


        "WORKING CAPITAL FACILITY LIMIT" means L6,000,000;


        "WORKING CAPITAL LENDER" means any Lender having a Working Capital
        Facility Commitment which is greater than zero;


        "WORKING CAPITAL LOAN" means a loan or utilisation made or to be made
        under the Working Capital Facility or the principal amount outstanding
        for the time being of that loan or utilisation;


        "WORKING CAPITAL OUTSTANDINGS" means, at any time, the aggregate of:

        (a)     all amounts outstanding in Sterling by way of overdraft under
                the Working Capital Facility;

        (b)     the Sterling Equivalent of all amounts outstanding by way of
                overdraft in the Optional Currency under the Working Capital
                Facility;

        (c)     the Guaranteed Amount of each Bank Guarantee issued by the
                Working Capital Bank;

        (d)     such amount calculated on a market to market basis as the
                Working Capital Bank may, in accordance with its then current
                credit policy accord as a risk weighting to all outstanding FFE
                Contracts; and

        (e)     in relation to any other facilities or financial accommodation
                provided under the Working Capital Facility, such other amounts
                as the Working Capital Bank determines fairly represents the
                aggregate exposure of the Working Capital Bank in respect of
                that facility or accommodation;


        "WORKING CAPITAL REPAYMENT DATE" means 31 December 2007.

1.2     CONSTRUCTION

1.2.1   Any reference in this Agreement to:

        (a)     "AGREED FORM" means in relation to a document the form agreed by
                the Parent and the Agent and initialled by them or on their
                behalf for the purpose of identification on the date of this
                Agreement or if not then agreed, in form and substance
                acceptable to the Agent;

        (b)     "ASSETS" includes present and future properties, revenues and
                rights of every description;


                                       24
   32
        (c)     a "FINANCE DOCUMENT" or any other agreement or instrument is a
                reference to that Finance Document or other agreement or
                instrument as amended or novated;

        (d)     "INDEBTEDNESS" includes any obligation (whether incurred as
                principal or as surety) for the payment or repayment of money,
                whether present or future, actual or contingent;

        (e)     a "PERSON" includes any person, firm, company, corporation,
                government, state or agency of a state or any association, trust
                or partnership (whether or not having separate legal
                personality) or two or more of the foregoing;

        (f)     a "REGULATION" includes any regulation, rule, official
                directive, request or guideline (whether or not having the force
                of law but if not, being a regulation, rule, official directive,
                request or guideline in accordance with which those to whom it
                is addressed customarily comply) of any governmental,
                intergovernmental or supranational body, agency, department or
                regulatory, self-regulatory or other authority or organisation;

        (g)     a provision of law is a reference to that provision as amended
                or re-enacted; and

        (h)     unless a contrary indication appears, a time of day is a
                reference to London time.

1.2.2   Section, Clause and Schedule headings are for ease of reference only.

1.2.3   Unless a contrary indication appears, a term used in any other Finance
        Document or in any notice given under or in connection with any Finance
        Document has the same meaning in that Finance Document or notice as in
        this Agreement.

1.2.4   A Default (other than an Event of Default) is "CONTINUING" if it has not
        been remedied or waived and an Event of Default is "CONTINUING" if it
        has not been waived.


                                       25
   33
1.3     CURRENCY CONVERSION


        Where any calculation of a monetary amount is required to be made in
        Sterling or Canadian Dollars under this Agreement and any sum forming
        part or the whole of such monetary amount is, or is to be denominated
        in, a currency other than Sterling, or as appropriate Canadian Dollars,
        such sum shall (except as otherwise provided for herein) for the
        purposes of such calculation be converted notionally into Sterling or as
        appropriate Canadian Dollars at the rate of exchange at which the Agent
        would have been able to make a spot purchase of such sum with Sterling
        or as appropriate Canadian Dollars in the London foreign exchange market
        at or about 11.00 a.m. on the second business day preceding the date as
        at which the calculation is to be made or, if the relevant date is not a
        day on which the London foreign exchange markets are open for spot
        transactions in Sterling or as appropriate Canadian Dollars and that
        currency, or the next following (or, if the Agent so determines, the
        immediately preceding) such day.

2       THE FACILITIES

2.1     THE FACILITIES


        Subject to the terms of this Agreement:

2.1.1 The Lenders make available to the Parent:

        (a)     a Sterling senior term loan facility in an aggregate amount
                equal to the Parent Series 1 Refinancing Term Facility
                Commitments;

        (b)     a Sterling senior term loan facility in an aggregate amount
                equal to the Parent Series 2 Refinancing Term Facility
                Commitments;

        (c)     a US Dollar (initially denominated) senior term loan facility in
                an aggregate amount equal to the Parent Series 1 Acquisition
                Term Facility Commitments;

        (d)     a US Dollar (initially denominated) senior term loan facility in
                an aggregate amount equal to the Parent Series 2 Acquisition
                Term Facility Commitments.

2.1.2   The Lenders make available to Canada Holdco:

        (a)     a US Dollar (initially denominated) senior term loan facility in
                an aggregate amount equal to the Canada Holdco Series 1
                Acquisition Term Facility Commitments;

        (b)     a US Dollar (initially denominated) senior term loan facility in
                an aggregate amount equal to the Canada Holdco Series 2
                Acquisition Term Facility Commitments; and

        (c)     a Canadian Dollar capital expenditure facility in an aggregate
                amount equal to the Total Capital Expenditure Facility
                Commitments.

2.1.3   The Working Capital Bank makes available to the Borrowers a Sterling
        working capital facility in an aggregate amount equal to the Total
        Working Capital Facility Commitments.


                                       26
   34
2.2     LENDER'S RIGHTS AND OBLIGATIONS

2.2.1   The obligations of each Lender under the Finance Documents are several.
        Failure by a Lender to perform its obligations under the Finance
        Documents does not affect the obligations of any other Party under the
        Finance Documents. No Finance Party is responsible for the obligations
        of any other Finance Party under the Finance Documents.

2.2.2   The rights of each Lender under or in connection with the Finance
        Documents are separate and independent rights and any debt arising under
        the Finance Documents to a Lender from an Obligor shall be a separate
        and independent debt.

2.2.3   A Finance Party may, except as otherwise stated in the Finance
        Documents, separately enforce its rights under the Finance Documents.

3       PURPOSE AND CONDITIONS PRECEDENT

3.1     PURPOSE

3.1.1   The Parent shall apply all amounts borrowed by it under the Parent
        Series 1 Refinancing Term Facility and the Parent Series 2 Refinancing
        Term Facility towards the refinancing of the Existing Inveresk
        Facilities.

3.1.2   Each relevant Borrower shall apply all amounts borrowed by it under the
        Parent Series 1 Acquisition Term Facility, the Parent Series 2
        Acquisition Term Facility, the Canada Holdco Series 1 Acquisition Term
        Facility and the Canada Holdco Series 2 Acquisition Term Facility
        towards:

        (a)     satisfaction of the consideration payable for Target Stock
                pursuant to the Tender Offer or any extension thereof;

        (b)     satisfaction of the consideration payable for Target Stock
                pursuant to the Merger; and

        (c)     payment of agreed costs and expenses in connection with the
                Tender Offer and the Merger.

3.1.3   Canada Holdco shall apply all amounts borrowed by it under the Capital
        Expenditure Facility towards capital expenditure incurred in expanding
        the capacity of Clintrials BioResearches Limited pre-clinical trials
        operations.

3.1.4   Each relevant Borrower shall utilise the Working Capital Facility for
        general working capital purposes and payment of fees and expenses in
        connection with the Merger but not to make prepayments of any Loan.

3.2     MONITORING


        No Finance Party is bound to monitor or verify the application of any
        amount borrowed pursuant to this Agreement.

3.3     INITIAL CONDITIONS PRECEDENT


        No Borrower may deliver a Utilisation Request in respect of any Loan or
        the Capital Expenditure Facility and no Borrower may make any
        Utilisation of the Working Capital Facility unless the Agent has
        received all the documents and other evidence


                                       27
   35
        listed in Part 1 of Schedule 3 each such document/item (other than
        Security Documents) being in form and substance satisfactory to the
        Agent and the following additional conditions have been satisfied:-

3.3.1   the Minimum Condition having been satisfied;

3.3.2   all conditions to the Tender Offer set forth in Annex A to the Merger
        Agreement shall have been satisfied (and a written confirmation from the
        Parent, acting reasonably and in good faith after consultation with the
        Agent, will satisfy this requirement) or (with the consent of the Agent)
        waived;

3.3.3   no event or matter has had a material adverse effect on the financial
        condition, assets or revenues of the Group taken as a whole having
        occurred (and a written confirmation from the Parent, acting reasonably
        and in good faith, will satisfy this requirement).

3.4     ADDITIONAL ACQUISITION TERM LOANS CONDITIONS PRECEDENT

3.4.1   No Borrower may deliver a Utilisation Request in respect of any Series 2
        Term Facility Loan unless the Available Facility in respect of all
        Series 1 Term Facilities is zero.

3.4.2   No Borrower may deliver a Utilisation Request in respect of the Parent
        Series 1 Acquisition Term Facility, the Parent Series 2 Acquisition Term
        Facility, the Canada Holdco Series 1 Acquisition Term Facility, and the
        Canada Holdco Series 2 Acquisition Term Facility unless:

        (a)     together with such Utilisation Request, the Borrower has
                delivered a duly completed and executed Form U-1 pursuant to
                Regulation U of the United States Board of Governors of the
                Federal Reserve System ("Regulation U"); and

        (b)     the aggregate outstanding balance of all Loans advanced under
                the Parent Series 1 Acquisition Term Facility, the Parent Series
                2 Acquisition Term Facility, the Canada Holdco Series 1
                Acquisition Term Facility, and the Canada Holdco Series 2
                Acquisition Term Facility, after giving effect to the advance
                pursuant to the Utilisation Request, does not exceed fifty per
                cent (50%) of the current market value (as defined in Regulation
                U) of the Target Stock, including the Target Stock to be
                acquired by the Borrower pursuant to the Utilisation Request,


        provided, however, that the foregoing conditions shall not apply if upon
        the acquisition of Target Stock pursuant to the Utilisation Request the
        Target Stock will not be "margin stock" as defined under Regulation U.

3.5     FURTHER CONDITIONS PRECEDENT

3.5.1   Subject to Clause 3.6 the Lenders will only be obliged to comply with
        Clause 4.1.4 if on the date of the Utilisation Request and on the
        proposed Utilisation Date:

        (a)     no Default is continuing or would result from the proposed Loan;
                and

        (b)     the Repeating Representations to be made by each Obligor are
                true in all material respects.


                                       28
   36
3.6     CERTAIN FUNDS PERIOD

3.6.1   Notwithstanding any other provision of this Agreement other than Clause
        3.4.2, during the Availability Period:

        (a)     the relevant Borrowers shall be entitled to utilise the Parent
                Series 1 Acquisition Term Facility Loans, Parent Series 2
                Acquisition Term Facility Loans, Canada Holdco Series 1
                Acquisition Term Facility Loans and Canada Holdco Series 2
                Acquisition Term Facility Loans and the Parent Series 1
                Refinancing Term Facility Loans and the Parent Series 2
                Refinancing Term Facility Loans and the Lenders shall be obliged
                make the Parent Series 1 Acquisition Term Facility Loans, Parent
                Series 2 Acquisition Term Facility Loans, Canada Holdco Series 1
                Acquisition Term Facility Loans and Canada Holdco Series 2
                Acquisition Term Facility Loans and the Parent Series 1
                Refinancing Term Facility Loans and the Parent Series 2
                Refinancing Term Facility Loans available despite the occurrence
                or existence of any Event of Default (other than prior to the
                Drawdown Date a Primary Default) or a breach of warranty (other
                than prior to the Drawdown Date a Primary Warranty) in order
                (and only to the extent) that US Newco is able to comply with
                its obligations under the Tender Offer and Merger Agreement to
                pay the consideration payable in relation to the acquisition of
                the Target Stock and to refinance the Existing Inveresk
                Facilities; and

        (b)     no Finance Party will have or seek to exercise any right of
                rescission or other remedy (whether under the Finance Documents
                or the general law) with a view to refusing to make any amount
                available under the facilities referred to in Clause 3.6.1(a).

3.6.2   The Borrowers acknowledge that the terms of Clause 3.6.1 above do not
        amount to a waiver of any Event of Default or Default and accordingly
        shall not prejudice any rights of the Agent and/or any of the other
        Finance Parties to exercise any rights under this Agreement or any
        rights of recission or other remedies in respect of any such Event of
        Default or Default or such other rights or remedies on the expiry of the
        Availability Period.

3.6.3   For the purposes of this Clause 3.6 and Clause 23.25 only, Clause 23.7
        shall be amended so as to appear in the following form:


        "Any distress, execution, arrestment, attachment, inhibition or other
        diligence or legal process affects any asset of any Material Company and
        such circumstances in the reasonable opinion of the Lenders could have a
        Material Adverse Effect; or"

3.6.4   For the purposes of this Clause 3.6 and Clause 23.25 only, Clause
        23.8(a) shall be amended so as to appear in the following form:


        "(a) any Material Company to be adjudicated or found insolvent other
        than proceedings which are proved to the satisfaction of the Agent,
        acting reasonably, to be frivolous or vexatious and which are discharged
        within 21 days of presentation;"


                                       29
   37
3.7     MAXIMUM NUMBER OF LOANS

3.7.1   The Parent may not deliver a Utilisation Request if as a result of the
        proposed Utilisation:

        (a)     2 or more Parent Series 1 Refinancing Term Facility Loans or 2
                or more Parent Series 2 Refinancing Term Facility Loans would be
                outstanding;

        (b)     6 or more Parent Series 1 Acquisition Term Facility Loans or 4
                or more Parent Series 2 Acquisition Term Facility Loans would be
                outstanding.

3.7.2   Canada Holdco may not deliver a Utilisation Request if as a result of
        the proposed Utilisation:

        (a)     6 or more Canada Holdco Series 1 Acquisition Term Facility Loans
                or 4 or more Canada Holdco Series 2 Acquisition Term Facility
                Loans would be outstanding;

        (b)     5 or more Capital Expenditure Facility Loans would be
                outstanding.

3.8     CONDITIONS RELATING TO CAPITAL EXPENDITURE FACILITY

3.8.1   The Lenders will only be obliged to comply with Clause 4.1.4 with
        respect to a Capital Expenditure Facility Loan if the Agent has received
        not less than 5 Business Days before the date of the Utilisation Request
        such evidence as it may reasonably require demonstrating the relevant
        Capital Expenditure Facility Loan both in amount and with regard to its
        intended application is in accordance with the relevant Operating
        Budget.

4       UTILISATION OF TERM LOANS

4.1     SERIES 1 TERM FACILITIES, SERIES 2 TERM FACILITIES AND CAPITAL
        EXPENDITURE FACILITIES

4.1.1   DELIVERY OF A UTILISATION REQUEST

4.1.1.1 Without prejudice to the terms of Clause 4.1.1.2 the relevant Borrower
        may utilise a Term Facility and the Capital Expenditure Facility by
        delivery to the Agent of a duly completed Utilisation Request not later
        than the Specified Time.

4.1.1.2 The Parent shall procure that an Original Borrower shall utilise the
        maximum aggregate principal amount of the Parent Series 1 Refinancing
        Term Facility and the Parent Series 2 Refinancing Term Facility
        simultaneously with the initial Utilisation of any of the other
        Facilities.

4.1.2   COMPLETION OF A UTILISATION REQUEST

4.1.2.1 Each Utilisation Request is irrevocable and will not be regarded as
        having been duly completed unless:

        (a)     it identifies the Facility to be utilised;

        (b)     the proposed Utilisation Date is a Business Day within the
                Availability Period applicable to that Facility;


                                       30
   38
        (c)     the currency and amount of the Utilisation comply with Clause
                4.1.3; and

        (d)     the proposed Interest Period complies with Clause 10.

4.1.2.2 Only one Loan may be requested in each Utilisation Request.

4.1.3   CURRENCY AND AMOUNT

4.1.3.1 The currency specified in a Utilisation Request must be the Base
        Currency.

4.1.3.2 The amount of a proposed Loan shall be a minimum of L5,000,000 in
        respect of the Parent Series 1 Refinancing Term Facility Loan or the
        Parent Series 2 Refinancing Term Facility (and in each case an integral
        multiple of L500,000); a minimum of US$1,000,000 in respect of the
        Parent Series 1 Acquisition Term Facility, the Parent Series 2
        Acquisition Term Facility, the Canada Holdco Series 1 Acquisition Term
        Facility and the Canada Holdco Series 2 Acquisition Term Facility (and
        in each case an integral multiple of US$250,000) and Canadian $1,500,000
        in respect of the Capital Expenditure Facility (and an integral multiple
        of C$300,000).

4.1.4   LENDERS' PARTICIPATION

4.1.4.1 If the conditions set out in this Agreement have been met, each Lender
        shall make its participation in each Loan available through its Facility
        Office.

4.1.4.2 The amount of each Lender's participation in each Loan will be equal to
        the proportion borne by its Available Commitment to the Available
        Facility immediately prior to making the Loan.

4.1.4.3 The Agent shall notify each Lender of the amount, currency and the
        amount of each Loan at the Specified Time.

5       RE-DENOMINATION OF ACQUISITION TERM LOANS

5.1     PARENT'S OPTION

        The Parent shall at any time during the Re-denomination Period be
        entitled to serve notice upon the Agent requiring all Loans made under
        the Canada Holdco Series 1 Acquisition Term Facility and the Canada
        Holdco Series 2 Acquisition Term Facility to be re-denominated in
        Canadian Dollars and all Loans made under the Parent Series 1
        Acquisition Term Facility and the Parent Series 2 Acquisition Term
        Facility to be re-denominated in Sterling.

5.2     AGENT'S OPTION

        If the Parent does not serve the notice contemplated by Clause 5.1
        before the expiry of the Re-denomination Period the Agent shall at any
        time during the period of one month from expiry of the Re-denomination
        Period be entitled to serve a notice upon the Parent requiring the
        re-denominations referred to in Clause 5.1.

5.3     NOTICE

        A notice by the Parent pursuant to Clause 5.1 or by the Agent pursuant
        to Clause 5.2 shall specify the proposed date of re-denomination (the
        "Re-denomination Date") which shall be not less than 3 Business Days
        after the date of the notice itself.


                                       31
   39
5.4     RE-DENOMINATION AMOUNT


        On the Re-denomination Date:

        (a)     all Loans made under the Canada Holdco Series 1 Acquisition Term
                Facility and the Canada Holdco Series 2 Acquisition Term
                Facility shall be repaid by the Relevant Borrower in US Dollars
                on that date and thereupon re-advanced in Canadian Dollars in
                the FFE Amount (or such other amount as may be relevant); and

        (b)     all Loans made under the Parent Series 1 Acquisition Term
                Facility and the Parent Series 2 Acquisition Term Facility shall
                be repaid by the Relevant Borrower in US Dollars on that date
                and thereupon re-advanced in Sterling in the FFE Amount (or such
                other amount as may be relevant);


        in each case as a separate Loan.

5.5     RE-DENOMINATION OF COMMITMENTS


        Upon the re-denomination of any Loans pursuant to this Clause 5 the
        Commitment of each Lender in respect of the relevant Loan shall be
        re-calculated as the amount (the "Re-denominated Commitment Amount") in
        the new currency which bears the same proportion to the total FFE Amount
        as its previous Commitment bore to the US Dollar amount repaid.

6       THE WORKING CAPITAL FACILITY

6.1     NATURE OF FACILITY

6.1.1   The Working Capital Facility is available for utilisation by any
        Borrower, subject to the other terms hereof, at any time during the
        Availability Period provided there has been an advance of any other
        Loan.

6.1.2   The Working Capital Facility is made available by the Working Capital
        Bank in an aggregate maximum principal amount equal to the Working
        Capital Facility Limit.

6.1.3   The Working Capital Facility shall, subject to Clauses 6.2.2 and 6.2.3,
        cease to be available on the Working Capital Repayment Date or such
        earlier date on which it is cancelled in accordance with the terms
        hereof.

6.1.4   Each Borrower shall complete such mandate and other documents in respect
        of the Working Capital Facility as the Working Capital Bank may require
        in accordance with its normal practice for commercial borrowers.

6.2     UTILISATION

6.2.1   Subject to the other terms of this Agreement, the Working Capital Bank
        agrees to make the Working Capital Facility available on a revolving
        basis to the Borrowers to be utilised on any Business Day by way of:

        (a)     issue of Bank Guarantees in Sterling or the Optional Currency;

        (b)     overdraft in Sterling or the Optional Currency on usual banking
                terms;

        (c)     FFE Contracts; and


                                       32
   40
        (d)     such other facilities or financial accommodation as the Working
                Capital Bank and the Borrowers may agree.

6.2.2   No utilisation of the Working Capital Facility under 6.2.1 shall be made
        if it would result in the Working Capital Outstandings exceeding the
        Working Capital Facility Limit.

6.2.3   No utilisation of the Working Capital Facility under Clause 6.2.1 may be
        made if on the date of the proposed utilisation a Default has occurred
        and is continuing or would occur on such utilisation except in respect
        of a utilisation of the Working Capital Facility to be made for the sole
        purpose of, (demand having been made under a Bank Guarantee issued by
        the Working Capital Bank), paying the amount guaranteed or otherwise
        assured under that Bank Guarantee or reimbursing the Working Capital
        Bank in respect of the amount properly paid by the Working Capital Bank
        under that Bank Guarantee, the utilisation of the Working Capital
        Facility shall be made notwithstanding the occurrence and intimation of
        a Default or any of the representations or warranties to be repeated not
        being correct, unless the Agent shall have served a notice of Default.

6.2.4   For the avoidance of doubt the Working Capital Bank may, without
        liability, return cheques unpaid if the payment of those would result in
        a breach of Clause 6.2.2.

6.2.5   The Working Capital Bank may, with the consent of the Majority Lenders,
        allow the Working Capital Facility Limit to be exceeded.

6.2.6   The issue by the Working Capital Bank of a Bank Guarantee in favour of
        any bank or financial institution in relation to any such facility shall
        itself be regarded for the purposes of this Agreement as a utilisation
        of the Working Capital Facility.

6.3     OPTIONAL CURRENCIES

6.3.1   Whenever a Borrower wishes an overdraft in the Optional Currency, it
        shall make a prior written request to the Working Capital Bank no later
        than 11.00 a.m. five Business Days before the proposed utilisation.

6.3.2   A Borrower may not create an overdraft under the Working Capital
        Facility in the Optional Currency unless the Working Capital Bank has
        confirmed to that Borrower that the Optional Currency is available by
        way of overdraft under the Working Capital Facility.

6.3.3   The Working Capital Bank shall promptly notify the relevant Borrower if
        it agrees with the Borrower that the Optional Currency can be utilised
        by way of the overdraft under the Working Capital Facility.

6.3.4   If in relation to any payment which is proposed to be denominated in the
        Optional Currency under the overdraft provided under the Working Capital
        Facility, the Working Capital Bank determines that:

        (a)     for whatever reason it is impractical for it to fund that amount
                in the Optional Currency in the ordinary course of business; or

        (b)     central bank or other governmental authorisation in the country
                of the Optional Currency is required to permit its use by the
                Working Capital Bank for the funding of that amount and the
                authorisation has not been


                                       33
   41
                obtained or is not in full force and effect or is subject to
                unacceptable conditions; or

        (c)     the use of the Optional Currency is restricted or prohibited by
                any request, directive, regulation or guideline of any
                governmental body, agency, department or regulatory or other
                authority (whether or not having the force of law) in accordance
                with which the Working Capital Bank is accustomed to act,


        then the Working Capital Bank shall notify the Borrower. If the Working
        Capital Bank so determines that one of the above circumstances applies
        and notwithstanding that it has not notified the Borrower of this the
        Working Capital Bank shall have no obligation to provide such funds and
        make the relevant payment in the Optional Currency under the Working
        Capital Facility.

6.4     EXCHANGE RATE MOVEMENTS

6.4.1   If on any day the Working Capital Outstandings exceed 105% of the
        Working Capital Facility Limit then the relevant Borrowers shall, within
        2 Business Days of receiving the Working Capital Bank's demand so to do,
        pay to the credit of their respective Cash Collateral Accounts such
        amounts as to ensure that the aggregate of:

        (a)     the Working Capital Outstandings, less

        (b)     the Sterling Equivalent (calculated on that day in accordance
                with the Working Capital Bank's usual practice) of all sums
                standing to the credit of the Cash Collateral Accounts on that
                day


        shall equal or be less than the Working Capital Facility Limit.

6.4.2   On each day, provided that no Default has occurred and is continuing,
        the Borrowers may withdraw such amounts standing to the credit of the
        Cash Collateral Accounts to ensure that, after payment of such amounts,
        the aggregate of:

        (a)     the Working Capital Outstandings, less

        (b)     the Sterling equivalent (calculated on that day in accordance
                with the Working Capital Bank's usual practice) of all sums, if
                any, standing to the credit of the Cash Collateral Accounts on
                that day


        is equal to or less than the Working Capital Facility Limit.

6.4.3   In this Clause 6.4, a "Cash Collateral Account" means in relation to a
        Borrower and the Optional Currency, an account of that Borrower in that
        currency held with the Working Capital Bank and designated as being in
        respect of the Working Capital Facility.

6.4.4   On the first occasion a Borrower is obliged to make a payment to a Cash
        Collateral Account it shall open that Cash Collateral Account and charge
        the same to the Security Trustee on terms satisfactory to the Security
        Trustee.

6.4.5   Except as expressly permitted in this Clause 6.4 no Borrower may
        withdraw any amount from a Cash Collateral Account.


                                       34
   42
6.5     FFE CONTRACTS

6.5.1   An FFE Contract shall:

        (a)     be on the usual terms of the Working Capital Bank;

        (b)     be of a duration of not more than 12 months;

        (c)     be on terms that the Working Capital Bank shall have no
                obligation to make payments under it at any time after the
                Working Capital Repayment Date unless the Working Capital Bank
                (in its sole discretion and upon such terms as it requires)
                agrees otherwise; and

        (d)     only be entered into on a Business Day.

6.5.2   All obligations and liabilities owing to the Working Capital Bank under
        or in respect of an FFE Contract shall be deemed to be obligations and
        liabilities owing to the Working Capital Bank under this Agreement.

6.6     BANK GUARANTEES

6.6.1   The Working Capital Bank shall not be obliged to issue any Bank
        Guarantee unless it has approved the form of the proposed Bank
        Guarantee.

6.6.2   No Bank Guarantee will be issued under which a claim could be made at a
        time after the Working Capital Repayment Date in relation to the Working
        Capital Facility unless the Working Capital Bank (in its sole discretion
        and upon such terms as it reasonably requires) agrees otherwise.

6.6.3   Each Bank Guarantee will be denominated in Sterling (or the Optional
        Currency if consented to by the Working Capital Bank) and shall state on
        its face the maximum amount payable under such Bank Guarantee and the
        expiry date of such Bank Guarantee.

6.6.4   A Bank Guarantee will only be issued on:

        (a)     a Business Day during the Working Capital Commitment Period; and

        (b)     if, on the relative Issue Date, the maximum amount payable under
                such Bank Guarantee does not exceed the Working Capital
                Available Amount.

6.6.5   Any Bank Guarantee shall be regarded as being in full force and effect
        and the Working Capital Bank shall be treated as having a liability
        thereunder unless and until such Bank Guarantee has expired in
        accordance with its terms without any claims having been made thereunder
        or that the beneficiary of such Guarantee has been satisfied and has
        released the Working Capital Bank from its obligations thereunder.


                                       35
   43
6.7        GUARANTEE REQUEST

           Whenever a Borrower wishes a Bank Guarantee to be issued by the
           Working Capital Bank, it shall give the Working Capital Bank a duly
           completed Guarantee Request together with a draft of the proposed
           Bank Guarantee to be received not later than 3 Business days prior to
           the relevant Issue Date.

6.8        COUNTER INDEMNITY FROM THE BORROWERS

           Each Borrower hereby unconditionally and irrevocably agrees and
           undertakes to the Agent, the Working Capital Bank and the Working
           Capital Lenders as follows:

6.8.1      it will at all times indemnify the Agent, the Working Capital Bank
           and each Working Capital Lender and keep the Agent, the Working
           Capital Bank and each Working Capital Lender indemnified from and
           against all actions, suits, proceedings, claims, demands,
           liabilities, damages, costs, expenses, losses and charges whatsoever
           in relation to or arising out of any Bank Guarantee issued hereunder
           for its account (except where the same results from the gross
           negligence or wilful misconduct of the Working Capital Bank) and it
           will pay the Working Capital Bank or the Agent for the account of the
           Working Capital Lenders (as the case may be) on demand the amount of
           all payments made (whether directly or by way of set-off,
           counterclaim or otherwise howsoever) and all losses, costs and
           expenses suffered or properly incurred from time to time by the
           Working Capital Bank and/or the Working Capital Lenders under or by
           reason or in consequence of any such Bank Guarantee (except where the
           same results from the gross negligence or wilful misconduct of the
           Working Capital Bank) and each Working Capital Lender Indemnity;

6.8.2      the Working Capital Bank is hereby irrevocably authorised by each
           Borrower to comply with the terms of any demand served or purporting
           to be served on the Working Capital Bank pursuant to any Bank
           Guarantee without any reference to, or further authority from, such
           Borrower for whose account such Bank Guarantee was issued and without
           any enquiry by the Working Capital Bank into the justification for
           such demand or the validity thereof and each Borrower further agrees
           that any payment which the Working Capital Bank shall make in
           accordance or purporting to be in accordance with such a demand shall
           be binding on such Borrower and be accepted by such Borrower as
           conclusive and binding evidence that the Working Capital Bank was
           liable to comply with the terms of such demand and was liable to do
           so in the manner and for the amount in which the Working Capital Bank
           effected such compliance;

6.8.3      the liability of any Borrower under this Clause 6.8 shall not be
           discharged, lessened or impaired by any time being given or by
           anything being done or other circumstance whatsoever which, but for
           this provision, would or might operate to exonerate or discharge such
           Borrower;

6.8.4      the indemnity contained in this Clause 6.8 shall constitute and be a
           continuing security to the Working Capital Bank and the said
           indemnity shall extend to each Bank Guarantee as it may, from time to
           time, be varied, modified, amended or extended;

6.8.5      the Working Capital Bank may claim under any Borrower Indemnity or
           under any Lender Indemnity in such order as the Working Capital Bank
           shall think fit.


                                       36
   44
           For the purpose of making a claim under this Clause 6.8 in its
           capacity as a Working Capital Lender the Working Capital Bank in its
           respective capacities as the Working Capital Bank and a Working
           Capital Lender will be treated as thought it were two separate legal
           entities and the Borrowers will be required to indemnify it under
           this Clause 6.8 in its capacity as a Working Capital Bank for
           payments made by it or deemed to have been made by it to the Working
           Capital Bank under Clause 6.9.

6.9        COUNTER INDEMNITY FROM THE WORKING CAPITAL LENDERS

6.9.1      If the relevant Borrower fails to pay to the Working Capital Bank any
           amount due under this Agreement in respect of the Working Capital
           Facility within two Business Days of its due date (the difference
           between the amount due and the amount paid being the "SHORTFALL")
           then, without limitation to all other rights and remedies of the
           Parties in respect thereof, the Working Capital Bank shall inform the
           Agent of such failure, specifying the amount and currency of the
           Shortfall whereupon the Agent shall issue a notification (a
           "SHORTFALL NOTIFICATION") to the Working Capital Lenders stating the
           amount and currency of the Shortfall.

6.9.2      Following the issue of a Shortfall Notification each Working Capital
           Lender shall pay to the Agent for the account of the Working Capital
           Bank an amount equal to a proportion of the Shortfall equal to such
           Working Capital Lender's Participation (as defined in Clause 6.10) in
           the Working Capital Facility together with interest thereon from the
           due date referred to in Clause 6.9.1 to the date of such payment to
           the Agent at the rate which is equal to the aggregate of:

           (a)        the Margin; and

           (b)        an amount equivalent to the cost of funds to the Working
                      Capital Bank (as certified by the Working Capital Bank).


           Such payments shall be made on the next Business day following the
           issuance of the Shortfall Notification and shall, subject to Clause
           6.9.3 satisfy the amount due (including interest thereon) from the
           relevant Borrower in respect of which such Shortfall arose to the
           extent of such payments. The Working Capital Lenders expressly
           acknowledge the provision of any BACS facilities and any excess which
           arises by virtue of BACS operations, shall (in the circumstances
           contemplated in Clause 6.9.1) be treated like any other amount
           forming all or part of a Shortfall and subject to reimbursement by
           the Working Capital Lenders pursuant to Clause 6.9.2.

6.9.3      The relevant Borrower shall, indemnify the Working Capital Lenders on
           demand against any amount payable by them under this Clause 6.9 and
           in respect of such indemnity the protective provisions in favour of
           the Security Trustee contained in any guarantee granted to the
           Security Trustee by any Group Company shall be deemed to apply
           mutatis mutandis.

6.9.4      For the avoidance of doubt, neither the Parent nor the relevant
           Borrower shall be obliged to make any payment in respect of the same
           amount more than once.

6.10       WORKING CAPITAL BANKS PARTICIPATION

           For the purposes of Clauses 6.9 and 9.2.8 the "participation" of a
           Working Capital Bank at any time in the Working Capital Facility
           shall be the proportion of the Working Capital Facility equal to the
           proportion borne by the Working Capital

                                       37
   45
           Bank's Working Capital Commitment to the Total Working Capital
           Commitments at such time.

6.11       INTEREST ON PAYMENTS

           Each Borrower hereby agrees that it shall pay interest on the amount
           of each payment, loss, cost and expense made, suffered or incurred
           from time to time by the Working Capital Bank under or by reason or
           in consequence of any Bank Guarantee issued for its account from and
           including the date upon which such payment, loss, cost or expense is
           made, suffered or incurred as aforesaid up to and including the date
           upon which payment or reimbursement of such amount is demanded from
           such Borrower which demand shall be made promptly by the Working
           Capital Bank upon it making the relevant payment or, as the case may
           be, becoming aware of the relevant loss, cost or expense. The amount
           of such interest shall be calculated in accordance with Clause 9.2.6.
           For the avoidance of doubt, interest on sums demanded under the
           provisions of this Clause 6.11 shall also accrue in accordance with
           Clause 9.2.6.

7          REPAYMENT

7.1        REPAYMENT OF SERIES 1 TERM FACILITIES

7.1.1      Each Borrower shall repay the Series 1 Term Facilities by paying the
           Agent on each date set out under Column A below (each a "SERIES 1
           TERM FACILITIES REPAYMENT DATE") in respect of each Series 1 Term
           Facility that amount (each a "SERIES 1 TERM FACILITIES REPAYMENT
           INSTALMENT") equal to (A x B) where:

           A =     the aggregate amount of its Series 1 Term Facilities Loans
                   under the relevant Series 1 Term Facility as at the expiry of
                   the Availability Period; and

           B =     the percentage specified in Column B below corresponding to
                   the relevant Series 1 Term Facilities Repayment Date,

           so that the Series 1 Term Facilities are repaid in full on or before
           the Final Repayment Date.



                            COLUMN A                         COLUMN B
            SERIES 1 TERM FACILITIES REPAYMENT DATES            %
            ---------------------------------------------------------
                                                          
            31 December 2001                                  2.00%
            30 June 2002                                      5.00%
            31 December 2002                                  5.00%
            30 June 2003                                      7.00%
            31 December 2003                                  7.00%
            30 June 2004                                      9.25%
            31 December 2004                                  9.25%
            30 June 2005                                      9.25%
            31 December 2005                                  9.25%
            30 June 2006                                      9.25%
            31 December 2006                                  9.25%
            30 June 2007                                      9.25%
            31 December 2007                                  9.25%



                                       38
   46
7.1.2      No Borrower may borrow any part of a Series 1 Term Facility which is
           repaid.

7.2        REPAYMENT OF SERIES 2 TERM FACILITIES

7.2.1      Each Borrower shall repay the Series 2 Term Facilities by paying the
           Agent on each date set out under Column A below (each a "SERIES 2
           TERM FACILITIES REPAYMENT DATE") in respect of each Series 2 Term
           Facility that amount (each a "SERIES 2 TERM FACILITIES REPAYMENT
           INSTALMENT") equal to (A x B) where:

           A =     the aggregate amount of its Series 2 Term Facilities Loans
                   under the relevant Series 2 Term Facility as at the expiry of
                   the Availability Period; and

           B =     the percentage specified in Column B below corresponding to
                   the relevant Series 2 Term Facilities Repayment Date,

           so that the Series 2 Term Facilities are repaid in full on or before
           the Final Repayment Date.



                            COLUMN A                         COLUMN B
            SERIES 2 TERM FACILITIES REPAYMENT DATES            %
            ---------------------------------------------------------
                                                          
            30 June 2008                                       50%
            31 December 2008                                   50%


7.2.2      No Borrower may borrow any part of a Series 2 Term Facility which is
           repaid.

7.3        REPAYMENT OF CAPITAL EXPENDITURE FACILITY

7.3.1      Each Borrower shall repay the Capital Expenditure Facility by paying
           the Agent on each date set out under Column A below (each a "CAPITAL
           EXPENDITURE FACILITY REPAYMENT DATE") that amount (each a "CAPITAL
           EXPENDITURE FACILITY REPAYMENT INSTALMENT") equal to (A X B) where:

           A =     the aggregate amount of Capital Expenditure Facility Loans as
                   at the expiry of the Availability Period; and


           B =     the percentage specified in Column B below corresponding to
                   the relevant Capital Expenditure Facility Repayment Date,


           so that the Capital Expenditure Facility is repaid in full on or
           before the Final Repayment Date.



                              COLUMN A                       COLUMN B
            CAPITAL EXPENDITURE FACILITY REPAYMENT DATES        %
            ---------------------------------------------------------
                                                          
            30 June 2003                                       10%
            31 December 2003                                   10%
            30 June 2004                                       10%




                                       39
   47


                              COLUMN A                       COLUMN B
            CAPITAL EXPENDITURE FACILITY REPAYMENT DATES        %
            ---------------------------------------------------------
                                                          
            31 December 2004                                   10%
            30 June 2005                                       10%
            31 December 2005                                   10%
            30 June 2006                                       10%
            31 December 2006                                   10%
            30 June 2007                                       10%
            31 December 2007                                   10%



7.3.2      No Borrower may borrow any part of the Capital Expenditure Facility
           which is repaid.

7.4        REPAYMENT OF WORKING CAPITAL FACILITY

           On the Final Repayment Date:

7.4.1      each Borrower shall repay any overdraft made available under the
           Working Capital Facility;

7.4.2      each Borrower shall in respect of each Bank Guarantee issued on its
           behalf under the Working Capital Facility:

7.4.2.1    use best endeavours to procure the release of the Working Capital
           Bank from such Bank Guarantee; and

7.4.2.2    without prejudice to Clause 7.4.2.1 above, pay to the credit of such
           account as the Working Capital Bank shall stipulate an amount equal
           to the Guaranteed Amount of that Bank Guarantee as cash cover and
           charge such amount in favour of the Security Trustee in such manner
           and on such terms as the Security Trustee may stipulate;

7.4.3      all other facilities or financial accommodation made available under
           the Working Capital Facility shall be terminated; and

7.4.4      each Working Capital Lender's Working Capital Commitment shall be
           reduced to zero.

8          PREPAYMENT AND CANCELLATION

8.1        ILLEGALITY

8.1.1      If it becomes unlawful in any jurisdiction for a Lender to perform
           any of its obligations as contemplated by this Agreement or to fund
           its participation in any Loan, Working Capital Loan or other
           Utilisation of the Working Capital Facility:

           (a)        that Lender shall promptly notify the Agent upon becoming
                      aware of that event;

           (b)        upon the Agent notifying the Parent, the Commitment of
                      that Lender will be immediately cancelled;

           (c)        each Borrower shall repay that Lender's participation in
                      the Loans made to or by that Borrower on the last day of
                      the Interest Period for each Loan

                                       40
   48
                      occurring after the Agent has notified the Parent or, if
                      earlier, the date specified by the Lender in the notice
                      delivered to the Agent (being no earlier than the last day
                      of any applicable grace period permitted by law); and

           (d)        if such Lender is also the Working Capital Bank, the
                      Borrowers shall repay all amounts outstanding under or in
                      relation to the Working Capital Facility as if a notice of
                      Default had been served.

8.1.2      If it is or becomes illegal for the Working Capital Bank to issue or
           leave outstanding any Bank Guarantee the Working Capital Facility
           shall cease to be available for the issue of Bank Guarantees and the
           Borrowers shall use their best endeavours to procure the release of
           each Bank Guarantee outstanding at such time.

8.2        CHANGE OF CONTROL/LISTING/SALE

8.2.1      If any person or group of persons acting in concert (other than the
           shareholders of the Parent as at the date of this Agreement) gains
           control of the Parent (disregarding for the purposes of this Clause
           any sale by the Investors of up to 50% of the issued share capital of
           the Parent in the context of any syndication by it) or there shall
           occur a Listing in respect of the Parent or a Sale:

           (a)        the Parent shall promptly notify the Agent upon becoming
                      aware of that event;

           (b)        the Agent may, by not less than 14 days notice to the
                      Parent, cancel the Facilities and declare all outstanding
                      Loans together with accrued interest, and all other
                      amounts accrued under the Finance Documents immediately
                      due and payable, whereupon the Facilities will be
                      cancelled and all such outstanding amounts will become
                      immediately due and payable.

8.2.2      For the purposes of this Clause 8.2 "CONTROL" means:

           (a)        the ability to control the composition of the Parent's
                      board of directors or equivalent body whether through
                      ownership of voting capital, by contract or otherwise; or

           (b)        the ownership of shares or the right to acquire shares in
                      the capital of the Parent conferring in the aggregate 50%
                      or more of the total voting rights conferred by all the
                      shares in the capital of the Parent for the time being; or

           (c)        the power to exercise voting rights conferring in the
                      aggregate 50% or more of the total voting rights conferred
                      by all the shares in the capital of the Parent for the
                      time being;

8.2.3      For the purposes of this Clause 8.2 "ACTING IN CONCERT" has the
           meaning given to it in the City Code on Takeovers and Mergers.

8.3        UNAPPLIED NET PROCEEDS

8.3.1      Without prejudice to any other provisions of this Agreement, if the
           aggregate amount of Unapplied Net Proceeds arising in any period of
           12 consecutive months is in excess of L500,000, the Borrowers shall,
           apply an amount equal to such

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           Unapplied Net Proceeds in prepaying (without premium or penalty, but
           without prejudice to Clause 11.4) such of the Series 1 Term
           Facilities or if all such Facilities are repaid in full, Series 2
           Term Facilities, as the Agent may direct on the next Interest Payment
           Date.

8.3.2      Where the Agent has served a notice under Clause 23, the Borrowers
           shall, following the receipt of the net proceeds in respect of any
           Relevant Disposal, apply (without premium or penalty, but without
           prejudice to Clause 11.4) such amount in prepayment of such of the
           Series 1 Term Facilities (or if all such Facilities are repaid in
           full, Series 2 Term Facilities) as the Agent may direct.

8.3.3      Pending every such prepayment as is referred to above or any
           Permitted Applications of the net proceeds of a Relevant Disposal the
           Parent shall on the date of each Relevant Disposal procure that an
           amount, or amounts in aggregate, equal to the net proceeds of such
           Relevant Disposal is placed in a Security Account with the Security
           Agent.

8.4        INSURANCE CLAIMS

8.4.1      The Borrowers shall following the receipt by any member of the
           Ringfenced Group of any amount in respect of insurance claims in
           excess of L500,000 apply (without premium or penalty, but without
           prejudice to Clause 11.4) such amount in prepayment of such of the
           Series 1 Term Facilities (or if all such Facilities are repaid in
           full, Series 2 Term Facilities) as the Agent may direct on the next
           Interest Payment Date unless such amount is utilised:

           (a)        in replacing, restoring or reinstating the property or
                      assets destroyed, damaged or lost or in discharging third
                      party liabilities insured by the relevant policy; or

           (b)        in relation to Keyman Insurance, in replacing the relevant
                      member of the Management Team; or

           (c)        where a member of the Group has incurred any expenditure
                      or has discharged any such liability are referred to in
                      (a) and (b) above, or in the case of any amount received
                      by a member of the Group from a loss of profits insurance
                      policy, in reimbursing such member of the Group.

8.5        RELEVANT RECEIPTS

8.5.1      The Borrowers shall following the receipt by any member of the
           Ringfenced Group of any amount (each such receipt being a "RELEVANT
           RECEIPT") in respect of claims under the Merger Agreement or in
           respect of Reports apply (without premium or penalty, but without
           prejudice to Clause 11.4) such amount in prepayment of such of the
           Series 1 Term Facilities (or if all such Facilities are repaid in
           full, Series 2 Term Facilities) as the Agent may direct on the next
           Interest Payment Date unless such amount is utilised:

           (a)        to the extent the Relevant Receipt relates to a liability
                      of, or a charge or claim upon, a member of the Group, in
                      the discharge of that liability, charge or claim (or in
                      reimbursement of monies disturbed in connection with such
                      liability, charge or claim) provided that such monies
                      shall be properly applied in such manner within three
                      months of receipt by the relevant member of the Group; or


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           (b)        to the extent the Relevant Receipt relates to an asset
                      reasonably required in the conduct of the Group's business
                      or to compensate for any current asset which is missing or
                      reduced in value, in the acquisition of that asset or in
                      compensation for the loss represented by that missing
                      current asset or reduction in value provided that such
                      monies shall be properly applied in such manner within six
                      months of receipt by the relevant member of the Group.

8.5.2      Where the Agent has served a notice under Clause 23, the Borrowers
           shall, following the receipt of any amounts in respect of insurance
           claims or any Relevant Receipt apply (without premium or penalty, but
           without prejudice to Clause 11.4) such amount in prepayment of such
           of the Series 1 Term Facilities (or if all such Facilities are repaid
           in full, Series 2 Term Facilities) as the Agent may direct.

8.5.3      Pending every such prepayment as is referred to above, or any
           permitted utilisation of Relevant Receipts as is referred to above,
           the Parent shall on the date of the Relevant Receipt procure that an
           amount, or amounts in aggregate, equal to the Relevant Receipt is
           placed in a Security Account with the Security Trustee.

8.6        NOTICE

           The Parent shall give the Agent at least 30 days prior notice of the
           date upon which a change of Control, Sale, or Listing is proposed to
           occur.

8.7        CASH SWEEP

           If upon any test as at 31 December in any year (in accordance with
           Clause 21.1.6) of the cash flow covenant referred to in Clause 21.1.4
           after the third anniversary of the signing of this Agreement the
           relevant ratio is met that sum representing 50% of the Surplus shall
           be applied in prepayment of such Series 1 Term Facilities (or if all
           such Facilities are repaid in full, Series 2 Term Facilities) as the
           Agent may direct on the first Interest Payment Date occurring after
           the relevant covenant test date; provided that in any circumstances
           where the terms of this Clause 8.7 would otherwise result in the
           payment of any costs by a Borrower in terms of Clause 11.4 the
           relevant prepayment shall be reduced in amount so as to avoid such
           costs and the amount of such reduction shall be applied in prepayment
           as contemplated by this Clause 8.7 but upon the then next succeeding
           Interest Payment Date. Declaring also, for the avoidance of doubt,
           that the terms of Clause 21.1.7 shall apply for the purposes of this
           Clause 8.7 to the intent and effect that calculations and prepayments
           pursuant to this Clause 8.7 shall initially be made on the basis of
           Management Accounts and the parties shall make any adjustment
           payments required upon retesting against audited financial
           statements.

8.8        VOLUNTARY CANCELLATION

           The Parent may, if it gives the Agent not less than 7 Business Days'
           (or such shorter period as the Majority Lenders may agree) prior
           notice, cancel the whole or any part (being a minimum amount of
           L250,000) of an Available Facility. Any cancellation under this
           Clause 8.8 shall reduce the Commitments of the Lenders rateably under
           that Facility.

8.9        VOLUNTARY PREPAYMENT OF SERIES 1 TERM FACILITIES


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8.9.1      A Borrower to which a Series 1 Term Facility Loan has been made may,
           if it gives the Agent not less than 7 Business Days' (or such shorter
           period as the Majority Lenders may agree) prior notice, prepay the
           whole or any part of the relevant Series 1 Term Facility Loan (but,
           if in part, being an amount which reduces the amount of the Term
           Facility 1 Loan by a minimum amount of L250,000 and which is an
           integral multiple of L250,000).

8.9.2      A Series 1 Term Facility Loan may only be prepaid after the last day
           of the relevant Availability Period (or, if earlier, the day on which
           the applicable Available Facility is zero).

8.9.3      Any prepayment under this Clause 8.9 shall be applied pro rata
           against the relevant future Series 1 Term Facility Repayment
           Instalments specified in Clause 7.1 until the relevant Series 1 Term
           Facility has been repaid in full.

8.10       VOLUNTARY PREPAYMENT OF SERIES 2 TERM FACILITIES

8.10.1     A Borrower to which a Series 2 Term Facility Loan has been made may,
           at any time after (but not before) repayment of all the Series 1 Term
           Facilities in full together with all interest thereon, if it gives
           the Agent not less than 7 Business Days' (or such shorter period as
           the Majority Lenders may agree) prior notice, prepay the whole or any
           part of any Series 2 Term Facility Loan (but if in part, being an
           amount which reduces the amount of the Series 2 Term Facility Loan by
           a minimum amount of L250,000 and which is an integral multiple of
           L250,000).

8.10.2     A Series 2 Term Facility Loan may only be prepaid after the last date
           of the Availability Period (or, if earlier, the day on which the
           applicable Available Facility is zero).

8.10.3     Any prepayment under this Clause 8.10 shall be applied pro rata
           against the relevant future Series 2 Term Facility Repayment
           Instalments specified in Clause 7.2 until the relevant Series 2 Term
           Facility 2 has been repaid in full.

8.11       VOLUNTARY PREPAYMENT OF CAPITAL EXPENDITURE FACILITY

8.11.1     A Borrower to which a Capital Expenditure Facility Loan has been made
           may, at any time after (but not before) repayment of Term Facility 1
           in full together with all interest thereon, if it gives the Agent not
           less than 7 Business Day's (or such shorter period as the Majority
           Lenders may agree) prior notice prepay the whole or any part of any
           Capital Expenditure Facility Loan (but, if in part, being an amount
           which reduces the amount of the Capital Expenditure Facility Loan by
           a minimum amount of L250,000 and which is an integral multiple of
           L250,000.

8.11.2     A Capital Expenditure Facility Loan may only be prepaid after the
           last day of the Availability Period or, if earlier, the day on which
           the applicable Available Facility is zero.

8.11.3     Any prepayment under this Clause 8.11 shall be applied pro rata
           against the future Capital Expenditure Facility Repayment Instalments
           specified in Clause 7.3 until the Capital Expenditure Facility has
           been repaid in full.

8.12       RIGHT OF REPAYMENT AND CANCELLATION IN RELATION TO A SINGLE LENDER

8.12.1     If:


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           (a)        any sum payable to any Lender by an Obligor is required to
                      be increased under paragraph (c) of Clause 13.2; or

           (b)        any Lender claims indemnification from the Parent under
                      Clause 13.3 or Clause 14.1,


           the Parent may, whilst the circumstance giving rise to the
           requirement or indemnification continues, give the Agent notice of
           cancellation of the Commitment of that Lender and its intention to
           procure the repayment of that Lender's participation in the Loans.

8.12.2     On receipt of a notice referred to in Clause 8.12.1, the Commitment
           of that Lender shall immediately be reduced to zero.

8.12.3     On the last day of each Interest Period which ends after the Parent
           has given notice under Clause 8.12.1 (or, if earlier, the date
           specified by the Parent in that notice), each Borrower to which a
           Loan is outstanding shall repay that Lender's participation in that
           Loan.

8.13       RESTRICTIONS

8.13.1     Any notice of cancellation or prepayment given by any Party under
           this Clause 8 shall be irrevocable and, unless a contrary indication
           appears in this Agreement, shall specify the date or dates upon which
           the relevant cancellation or prepayment is to be made and the amount
           of that cancellation or prepayment.

8.13.2     Any prepayment under this Agreement shall be made together with
           accrued interest on the amount prepaid and, subject to any Break
           Costs, without premium or penalty save that where any prepayment or
           cancellation of all or any part of the Loans or the Facilities
           (including for the avoidance of doubt the Working Capital Facility)
           other than in the circumstances contemplated in Clause 8.1.1 or
           8.12.1 is made pursuant to, in contemplation of or otherwise in
           connection with a refinancing of the Facilities (or part of them)
           (including for the avoidance of doubt the Working Capital Facility)
           during the period of 18 months commencing on the Drawdown Date by any
           bank or financial institution other than the Lenders, the Parent
           shall promptly on demand by the Agent pay the Agent on account of the
           Lenders (or as appropriate the Working Capital Bank) a prepayment fee
           equal to one per cent (1%) of the amount prepaid or cancelled on the
           Business Day immediately prior to such prepayment or cancellation.

8.13.3     The Borrowers shall not repay or prepay all or any part of the Loans
           or cancel all or any part of the Commitments (including the Working
           Capital Facility Commitments) except at the times and in the manner
           expressly provided for in this Agreement.

8.13.4     No amount of the Total Commitments cancelled under this Agreement may
           be subsequently reinstated.

8.13.5     If the Agent receives a notice under this Clause 8 it shall promptly
           forward a copy of that notice to either the Parent or the affected
           Lender, as appropriate.

9          INTEREST ETC


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9.1        SERIES 1 TERM FACILITIES, SERIES 2 TERM FACILITIES AND CAPITAL
           EXPENDITURE FACILITIES

9.1.1      CALCULATION OF INTEREST

           The rate of interest on each Loan for each Interest Period is the
           percentage rate per annum which is the aggregate of the applicable:

           (a)        Margin;

           (b)        LIBOR; and

           (c)        Mandatory Cost, if any.

9.1.2      PAYMENT OF INTEREST

           Each Borrower to which a Loan has been made shall pay accrued
           interest on that Loan on the last day of each Interest Period (and,
           if the Interest Period is longer than six months, on the dates
           falling at six monthly intervals after the first day of the Interest
           Period).

9.1.3      DEFAULT INTEREST

9.1.3.1    If an Obligor fails to pay any amount payable by it under a Finance
           Document in respect of a Series 1 Term Facility Loan, Series 2 Term
           Facility Loan or a Capital Expenditure Loan on its due date, interest
           shall accrue on the overdue amount from the due date up to the date
           of actual payment (both before and after judgment) at a rate one per
           cent 1% higher than the rate which would have been payable if the
           overdue amount had, during the period of non-payment, constituted a
           Loan in the currency of the overdue amount for successive Interest
           Periods, each of a duration selected by the Agent (acting
           reasonably). Any interest accruing under this Clause 9.1.3.1 shall be
           immediately payable by the Borrower on demand by the Agent.

9.1.3.2    Default interest (if unpaid) arising on an overdue amount will be
           compounded with the overdue amount at the end of each Interest Period
           applicable to that overdue amount but will remain immediately due and
           payable.

9.1.4      NOTIFICATION OF RATES OF INTEREST

           The Agent shall promptly notify the Lenders and the relevant Borrower
           of the determination of a rate of interest under this Agreement.

9.2        WORKING CAPITAL FACILITY

9.2.1      OVERDRAFT INTEREST

           Interest on all amounts outstanding by way of overdraft under the
           Working Capital Facility shall accrue at the rate per annum which is
           the aggregate of:

9.2.1.1    the Margin; and

9.2.1.2    in respect of any amounts denominated in Sterling outstanding under
           the overdraft the most recently published base rate of the Working
           Capital Bank from time to time or, in respect of any amounts
           denominated in the Optional Currency

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           outstanding under the overdraft Canadian LIBOR as quoted in the
           London financial markets.

9.2.2      PAYMENT AND ACCRUAL

           Interest under Clause 9.2.1 on amounts outstanding by way of
           overdraft under the Working Capital Facility shall be paid by the
           relevant Borrower to the Working Capital Bank, on the Working Capital
           Bank's usual quarterly charging days and the Working Capital
           Repayment Date and will accrue from day to day on the basis of actual
           days elapsed and a year of 365 days (in the case of Sterling
           borrowings) or 360 days (in the case of Canadian Dollar or Optional
           Currency (other than Sterling) borrowings).

9.2.3      FFE CONTRACTS

           In respect of each FFE Contract, the relevant Borrower shall pay fees
           and commissions to the Working Capital Bank in accordance with the
           Working Capital Bank's usual charging scales as notified to the
           Company from time to time for entering into forward foreign exchange
           contracts.

9.2.4      GUARANTEE COMMISSION

9.2.4.1    In respect of each Bank Guarantee issued by the Working Capital Bank
           under the Working Capital Facility each Borrower for whose account
           such Bank Guarantee is issued shall pay commission on the Guaranteed
           Amount of such Bank Guarantee from the date of its issue until it has
           ceased to be in full force and effect in accordance with Clause 6.6.5
           at a rate per annum equal to the Margin which shall:

           (a)        accrue from day to day on the Guaranteed Amount of such
                      Bank Guarantee; and

           (b)        be calculated on the basis of actual days elapsed and a
                      365 day year if the Guarantee is denominated in Sterling
                      and 360 days if in any other currency unless the normal
                      market practice in respect of that currency is for
                      calculations to be made on the basis of a year of 360 days
                      in which case that practice will be adopted.

9.2.4.2    Each Bank Guarantee will be deemed to have been issued on behalf of
           the Borrower specified in the Guarantee Request relating to that Bank
           Guarantee.

9.2.4.3    For the purpose of calculating the amount of guarantee commission
           payable from time to time the period of issue of each Bank Guarantee
           shall be divided into successive three months periods (each a
           "GUARANTEE COMMISSION PERIOD") each of which (other than the first
           which shall begin on the first date on which a Bank Guarantee is
           issued) shall begin on the expiry of the preceding one. If the full
           period of the Bank Guarantee does not exceed 3 months the guarantee
           commission period relating thereto shall be such full period. The
           guarantee commission shall be payable in arrear on the last day of
           each guarantee commission period or, if earlier, on the date on which
           the Guaranteed Amount in respect of such Bank Guarantee is reduced to
           nil.

9.2.5      OTHER UTILISATIONS


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           Any other facilities or financial accommodation made available under
           the Working Capital Facility shall be charged to the relevant
           Borrower by the Working Capital Bank in accordance with its customary
           rates or scales as notified to the Borrower from time to time.

9.2.6      DEFAULT INTEREST

           If a Borrower fails to pay an amount of principal, interest or any
           other sum (an "OVERDUE SUM") when it is due in respect of the Working
           Capital Facility, interest shall accrue on the overdue sum from the
           due date up to the date of actual payment (both before and after
           decree or judgement). Such interest shall be calculated and payable
           by reference to successive periods ("DEFAULT PERIODS") each of such
           duration as the Agent may select. The first Default Period shall
           begin on the due date and all subsequent Default Periods shall begin
           on the last day of the previous one. The rate of interest for each
           such Default Period shall be the rate per annum (as determined by the
           Agent) equal to the sum of one per cent (1%) higher than the rate,
           charge or commission determined in accordance with this Clause 9.2 in
           respect of the relevant Utilisation. Any interest payable under this
           Clause 9.2.6 which is not paid when due shall be deemed an overdue
           sum and shall itself bear interest accordingly.

9.2.7      DEBITING OF ACCOUNTS

           Each Borrower hereby authorised the Working Capital Bank to debit all
           interest, fees and commissions due and payable by such Borrower under
           this Clause 9.2 to any account held by the Borrower with the Working
           Capital Bank.

9.2.8      PAYMENTS TO WORKING CAPITAL BANKS

           Upon receipt of the same the Working Capital Bank shall pay to the
           Agent for the account of the Working Capital Banks the Margin which
           it receives in respect of the Working Capital Facility and each
           Working Capital Lender shall participate in the same in its relevant
           participation (as defined in Clause 6.10).

10         INTEREST PERIODS

10.1       SELECTION OF INTEREST PERIODS

10.1.1     A Borrower (or the Parent on behalf of a Borrower) may select an
           Interest Period for a Loan in the Utilisation Request for that Loan
           or (if the Loan has already been borrowed) in a Selection Notice.

10.1.2     Each Selection Notice for a Series 1 Term Facility Loan, Series 2
           Term Facility Loan or Capital Expenditure Facility Loan is
           irrevocable and must be delivered to the Agent by the Borrower (or
           the Parent on behalf of a Borrower) to which that Loan was made not
           later than the Specified Time.

10.1.3     If a Borrower (or the Parent) fails to deliver a Selection Notice to
           the Agent in accordance with Clause 10.1.2, the relevant Interest
           Period will, subject to Clause 10.2, be one Month.

10.1.4     Subject to this Clause 10 a Borrower (or the Parent) may select an
           Interest Period of one, three or six months or any other period
           agreed between the Parent and the Agent (acting on the instructions
           of all the Lenders).


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10.1.5     In addition a Borrower (or the Parent on its behalf) may select an
           Interest Period in relation to the Series 1 Term Facility, Series 2
           Term Facility or Capital Expenditure Facility of a period of less
           than one month, if necessary to ensure that in respect of the
           relevant Facility there are Loans (with an aggregate amount equal to
           or greater than the relevant Repayment Instalment) which have an
           Interest Period ending on a Repayment Date for the Borrower to make
           the Repayment Instalment due on that date.

10.1.6     An Interest Period for a Loan shall not extend beyond the Final
           Repayment Date applicable to its Facility.

10.1.7     Each Interest Period for a Series 1 Term Facility Loan, Series 2 Term
           Facility Loan and Capital Expenditure Facility Loan shall start on
           the Utilisation Date or (if already made) on the last day of its
           preceding Interest Period.

10.1.8     Notwithstanding any other provision of this Agreement to the contrary
           each Borrower shall select such Interest Periods under the terms of
           this Agreement as may be necessary to ensure that to the extent there
           exists any Hedging Agreement applicable to any Loan borrowed by the
           relevant Borrower the Interest Periods applicable thereto coincide
           with scheduled payment dates under the relevant Hedging Agreement.

10.2       CHANGES TO INTEREST PERIODS

10.2.1     Prior to determining the interest rate for a Series 1 Term Facility
           Loan, Series 2 Term Facility Loan or Capital Expenditure Facility
           Loan the Agent may shorten an Interest Period for the relevant Loan
           to ensure there are sufficient Loans in respect of the relevant
           Facility with an Interest Period ending on a Repayment Date for the
           relevant Borrower to make the Repayment Instalment due on the
           relevant Repayment Date.

10.2.2     If the Agent makes any of the changes to an Interest Period referred
           to in this Clause 10.2, it shall promptly notify the Parent and the
           Lenders.

10.3       NON-BUSINESS DAYS

           If an Interest Period would otherwise end on a day which is not a
           Business Day, that Interest Period will instead end on the next
           Business Day in that calendar month (if there is one) or the
           preceding Business Day (if there is not).

11         CHANGES TO THE CALCULATION OF INTEREST

11.1       ABSENCE OF QUOTATIONS

           Subject to Clause 11.2, if LIBOR is to be determined by reference to
           the Reference Lenders but a Reference Lender does not supply a
           quotation by the Specified Time on the Quotation Day, the applicable
           LIBOR shall be determined on the basis of the quotations of the
           remaining Reference Lenders.

11.2       MARKET DISRUPTION

11.2.1     If a Market Disruption Event occurs in relation to a Loan for any
           Interest Period, then the rate of interest on each Lender's share of
           that Loan for the Interest Period shall be the rate per annum which
           is the sum of:


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           (a)        the Margin;

           (b)        the rate notified to the Agent by that Lender as soon as
                      practicable and in any event before interest is due to be
                      paid in respect of that Interest Period, to be that which
                      expresses as a percentage rate per annum the cost to that
                      Lender of funding its participation in that Loan from
                      whatever source it may reasonably select; and

           (c)        the Mandatory Cost, if any, applicable to that Lender's
                      participation in the Loan.

11.2.2     In this Agreement "MARKET DISRUPTION EVENT" means:

           (a)        at or about noon on the Quotation Day for the relevant
                      Interest Period the Screen Rate is not available and none
                      of the Reference Lenders supplies a rate to the Agent to
                      determine LIBOR for the relevant currency and period; or

           (b)        before close of business in London on the Quotation Day
                      for the relevant Interest Period, the Agent receives
                      notifications from a Lender or Lenders (whose
                      participations in a Loan exceed fifty per cent. of that
                      Loan) that the cost to it or them of obtaining matching
                      deposits in the Relevant Interbank Market would be in
                      excess of LIBOR.

11.3       ALTERNATIVE BASIS OF INTEREST OR FUNDING

11.3.1     If a Market Disruption Event occurs and the Agent or the Parent so
           requires, the Agent and the Parent shall enter into negotiations (for
           a period of not more than thirty days) with a view to agreeing a
           substitute basis for determining the rate of interest.

11.3.2     Any substitute basis agreed pursuant to Clause 11.3.1 shall, with the
           prior consent of all the Lenders and the Parent, be binding on all
           Parties.

11.4       BREAK COSTS

11.4.1     Each Borrower shall, within three Business Days of demand by a
           Finance Party, pay to that Finance Party its Break Costs attributable
           to all or any part of a Loan or Unpaid Sum being paid by that
           Borrower on a day other than the last day of an Interest Period for
           that Loan or Unpaid Sum.

11.4.2     Each Lender shall, as soon as reasonably practicable after a demand
           by the Agent, provide a certificate confirming the amount of its
           Break Costs for any Interest Period in which they accrue.


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12         FEES

12.1       COMMITMENT FEES

12.1.1     The Parent shall pay to the Agent (for the account of the Working
           Capital Banks in relation to the Working Capital Facility, and for
           the account of each Lender in relation to the other Facilities) a fee
           computed at the rate of:

           (a)        0.75 per cent. per annum on that Lender's Available
                      Commitment under each Series 1 Term Facility for the
                      Availability Period applicable to the Series 1 Term
                      Facilities;

           (b)        0.75 per cent. per annum on that Lender's Available
                      Commitment under the each Series 2 Term Facility for the
                      Availability Period applicable to the Series 2 Term
                      Facilities;

           (c)        0.75 per cent. per annum on that Lender's Available
                      Commitment under the Capital Expenditure Facility for the
                      Availability Period applicable to the Capital Expenditure
                      Facility;

           (d)        0.75 per cent per annum on the Working Capital Banks
                      Working Capital Available Amount for the Availability
                      Period applicable to the Working Capital Facility.

12.1.2     Subject to Clause 12.1.3 the accrued commitment fees are payable in
           the case of paragraphs (a) and (b) above on the expiry of the
           Availability Period and in the case of paragraphs (c) and (d) above
           on the last day of each successive period of three Months which ends
           during the relevant Availability Period, on the last day of the
           Availability Period and on the cancelled amount of the relevant
           Lender's or Working Capital Banks' Commitment (as the case may be) at
           the time the cancellation is effective.

12.1.3     Upon cancellation of any Facility any accrued commitment fees in
           respect of that Facility shall be immediately payable.

13         TAX GROSS UP AND INDEMNITIES

13.1       DEFINITIONS

13.1.1     In this Clause 13:

           "PROTECTED PARTY" means a Finance Party which is or will be, for or
           on account of Tax, subject to any liability or required to make any
           payment in relation to a sum received or receivable (or any sum
           deemed for the purposes of Tax to be received or receivable) under a
           Finance Document.

           "QUALIFYING LENDER" means a Finance Party which is (on the date a
           payment falls due):

           (a)        within the charge to United Kingdom corporation tax as
                      respects that payment and is a Finance Party in respect of
                      an advance made by a person which was a bank (as defined
                      for the purpose of section 349 of the Taxes Act in section
                      840A of the Taxes Act) at the time that advance was made;
                      or


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           (b)        entitled to that payment under a double taxation agreement
                      in force on the date (subject to the completion of any
                      necessary procedural formalities) without a Tax Deduction
                      (a "TREATY Lender").

           "TAX CREDIT" means a credit against, relief or remission for, or
           repayment of any Tax.

           "TAX DEDUCTION" means a deduction or withholding for or on account of
           Tax from a payment under a Finance Document.

           "TAX PAYMENT" means an increased payment made by an Obligor to a
           Finance Party under Clause 13.2 or a payment under Clause 13.3.

13.1.2     In this Clause 13 a reference to "determines" or "determined" means a
           determination made in the absolute discretion of the person making
           the determination.

13.2       TAX GROSS-UP

13.2.1     Each Obligor shall make all payments to be made by it without any Tax
           Deduction, unless a Tax Deduction is required by law.

13.2.2     The Parent or a Lender or the Working Capital Bank shall promptly
           upon becoming aware that an Obligor must make a Tax Deduction (or
           that there is any change in the rate or the basis of a Tax Deduction)
           notify the Agent accordingly. If the Agent receives such notification
           from a Lender or the Working Capital Bank it shall notify the Parent
           and that Obligor.

13.2.3     If a Tax Deduction is required by law to be made by an Obligor in one
           of the circumstances set out in Clause 13.2.4, the amount of the
           payment due from that Obligor shall be increased to an amount which
           (after making any Tax Deduction) leaves an amount equal to the
           payment which would have been due if no Tax Deduction had been
           required.

13.2.4     The circumstances referred to in Clause 13.2.3 are where a person
           entitled to the payment:

           (a)        is the Agent or the Arranger (on its own behalf); or

           (b)        is a Qualifying Lender, unless that Qualifying Lender is a
                      Treaty Lender and the Obligor making the payment is able
                      to demonstrate the Tax Deduction is required to be made as
                      a result of the failure of that Qualifying Lender to
                      comply with Clause 13.2.7; or

           (c)        is not or has ceased to be a Qualifying Lender to the
                      extent that this altered status results from any change
                      after the date of this Agreement in (or in the
                      interpretation, administration, or application of) any law
                      or double taxation agreement or any published practice or
                      published concession of any relevant taxing authority.

13.2.5     If an Obligor is required to make a Tax Deduction, that Obligor shall
           make that Tax Deduction and any payment required in connection with
           that Tax Deduction within the time allowed and in the minimum amount
           required by law.

13.2.6     Within thirty days of making either a Tax Deduction or any payment
           required in connection with that Tax Deduction, the Obligor making
           that Tax Deduction shall

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           deliver to the Agent for the Finance Party entitled to the payment
           evidence reasonably satisfactory to that Finance Party that the Tax
           Deduction has been made or (as applicable) any appropriate payment
           paid to the relevant taxing authority.

13.2.7     A Treaty Lender and each Obligor which makes a payment to which that
           Treaty Lender is entitled shall co-operate in completing any
           procedural formalities necessary for that Obligor to obtain
           authorisation to make that payment without a Tax Deduction.

13.3       TAX INDEMNITY

13.3.1     The Parent shall (within three Business Days of demand by the Agent)
           pay to a Protected Party an amount equal to the loss, liability or
           cost which that Protected Party determines will be or has been
           (directly or indirectly) suffered for or on account of Tax by that
           Protected Party.

13.3.2     Clause 13.3.1 above shall not apply with respect to any Tax assessed
           on:

           (a)        a Finance Party:

                      (i)        under the law of the jurisdiction in which that
                                 Finance Party is incorporated or, if different,
                                 the jurisdiction (or jurisdictions) in which
                                 that Finance Party is treated as resident for
                                 tax purposes; or

                      (ii)       under the law of the jurisdiction in which that
                                 Finance Party's Facility Office is located in
                                 respect of amounts received or receivable in
                                 that jurisdiction,


                      if that Tax is imposed on or calculated by reference to
                      the net income received or receivable (but not any sum
                      deemed to be received or receivable) by that Finance
                      Party; or

           (b)        the Agent, as a result of the failure by a Lender to
                      satisfy on the due date of a payment of interest either of
                      the conditions set out in paragraphs (a) and (b) of Clause
                      27.15.

13.3.3     A Protected Party making, or intending to make a claim pursuant to
           Clause 13.3.1 shall promptly notify the Agent of the event which will
           give, or has given, rise to the claim, following which the Agent
           shall notify the Parent.

13.3.4     A Protected Party shall, on receiving a payment from an Obligor under
           this Clause 13.3, notify the Agent.

13.4       TAX CREDIT

           If an Obligor makes a Tax Payment and the relevant Finance Party
           determines that:

           (a)        a Tax Credit is attributable to that Tax Payment; and

           (b)        that Finance Party has obtained, utilised and retained
                      that Tax Credit,


           the Finance Party shall pay an amount to the Obligor which that
           Finance Party determines will leave it (after that payment) in the
           same after-Tax position as it would have been in had the Tax Payment
           not been made by the Obligor.


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13.5       STAMP TAXES

           The Parent shall pay and, within three Business Days of demand,
           indemnify each Finance Party against any cost, loss or liability that
           Finance Party incurs in relation to all stamp duty, registration and
           other similar Taxes payable in respect of any Finance Document.

13.6       VALUE ADDED TAX

13.6.1     All consideration payable under a Finance Document by an Obligor to a
           Finance Party shall be deemed to be exclusive of any VAT. If VAT is
           chargeable, the Obligor shall pay to the Finance Party (in addition
           to and at the same time as paying the consideration) an amount equal
           to the amount of the VAT.

13.6.2     Where a Finance Document requires an Obligor to reimburse a Finance
           Party for any costs or expenses, that Obligor shall also at the same
           time pay and indemnify that Finance Party against all VAT incurred by
           that Finance Party in respect of the costs or expenses save to the
           extent that that Finance Party is entitled to repayment or credit in
           respect of the VAT.

14         INCREASED COSTS

14.1       INCREASED COSTS

14.1.1     Subject to Clause 14.3 the Parent shall, within three Business Days
           of a demand by the Agent, pay for the account of a Finance Party the
           amount of any Increased Costs incurred by that Finance Party or any
           of its Affiliates as a result of:

           (a)        the introduction of or any change in (or in the
                      interpretation or application of) any law or regulation;
                      or

           (b)        compliance with any law or regulation made after the date
                      of this Agreement.

14.1.2     In this Agreement "INCREASED COSTS" means:

           (a)        a reduction in the rate of return from any Facility or on
                      a Finance Party's (or its Affiliate's) overall capital;

           (b)        an additional or increased cost; or

           (c)        a reduction of any amount due and payable under any
                      Finance Document,


           which is incurred or suffered by a Finance Party or any of its
           Affiliates to the extent that it is attributable to that Finance
           Party having entered into its Commitment or funding or performing its
           obligations under any Finance Document.

14.2       INCREASED COST CLAIMS

14.2.1     A Finance Party intending to make a claim pursuant to Clause 14.1
           shall notify the Agent of the event giving rise to the claim,
           following which the Agent shall promptly notify the Parent.

14.2.2     Each Finance Party shall, as soon as practicable after a demand by
           the Agent, provide a certificate confirming the amount of its
           Increased Costs.


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14.3       EXCEPTIONS

14.3.1     Clause 14.1 does not apply to the extent any Increased Cost is:

           (a)        attributable to a Tax Deduction required by law to be made
                      by an Obligor;

           (b)        compensated for by Clause 13.3 (or would have been
                      compensated for under Clause 13.3 but was not so
                      compensated solely because one of the exclusions in Clause
                      13.3.2 applied);

           (c)        compensated for by the payment of the Mandatory Cost; or

           (d)        attributable to the wilful breach by the relevant Finance
                      Party or its Affiliates of any law or regulation.

14.3.2     In this Clause 14.3, a reference to a "TAX DEDUCTION" has the same
           meaning given to the term in Clause 13.1.

15         OTHER INDEMNITIES

15.1       CURRENCY INDEMNITY

15.1.1     If any sum due from an Obligor under the Finance Documents (a "SUM"),
           or any order, judgment or award given or made in relation to a Sum,
           has to be converted from the currency (the "FIRST CURRENCY") in which
           that Sum is payable into another currency (the "SECOND CURRENCY") for
           the purpose of:

           (a)        making or filing a claim or proof against that Obligor;

           (b)        obtaining or enforcing an order, decree, judgment or award
                      in relation to any litigation or arbitration proceedings,


           that Obligor shall as an independent obligation, within three
           Business Days of demand, indemnify each Finance Party to whom that
           Sum is due against any cost, loss or liability arising out of or as a
           result of the conversion including any discrepancy between:

                      (i)        the rate of exchange used to convert that Sum
                                 from the First Currency into the Second
                                 Currency; and

                      (ii)       the rate or rates of exchange available to that
                                 person at the time of its receipt of that Sum.

15.1.2     Each Obligor waives any right it may have in any jurisdiction to pay
           any amount under the Finance Documents in a currency or currency unit
           other than that in which it is expressed to be payable.

15.2       OTHER INDEMNITIES

           The Parent shall (or shall procure that an Obligor will), within
           three Business Days of demand, indemnify each Finance Party against
           any cost, loss or liability incurred by that Finance Party as a
           result of:

           (a)        the occurrence of any Event of Default;


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          (b)       a failure by an Obligor to pay any amount due under a
                    Finance Document on its due date;


          (c)       funding, or making arrangements to fund, its participation
                    in a Loan requested by a Borrower in a Utilisation Request
                    or a proposed Utilisation under the Working Capital Facility
                    but not made by reason of the operation of any one or more
                    of the provisions of this Agreement (other than by reason of
                    default or negligence by that Lender alone); or

          (d)       a Loan (or part of a Loan) not being prepaid in accordance
                    with a notice of prepayment given by a Borrower or the
                    Parent.


15.3      INDEMNITY TO THE AGENT


          The Parent shall promptly indemnify the Agent against any cost, loss
          or liability incurred by the Agent (acting reasonably) as a result of:

          (a)       investigating any event which it reasonably believes is a
                    Default following consultation on such matter with the
                    Parent; or

          (b)       acting or relying on any notice, request or instruction
                    which it reasonably believes to be genuine, correct and
                    appropriately authorised.

16        MITIGATION BY THE FINANCE PARTIES

16.1      MITIGATION

16.1.1    Each Finance Party shall, in consultation with the Parent, take all
          reasonable steps to mitigate any circumstances which arise and which
          would result in any amount becoming payable under, or cancelled
          pursuant to, any of Clause 8.1, Clause 13 or Clause 14 including (but
          not limited to) transferring its rights and obligations under the
          Finance Documents to another Affiliate or Facility Office.

16.1.2    Clause 16.1.1 does not in any way limit the obligations of any Obligor
          under the Finance Documents.

16.2      LIMITATION OF LIABILITY

16.2.1    The Parent shall indemnify each Finance Party for all costs and
          expenses reasonably incurred by that Finance Party as a result of
          steps taken by it under Clause 16.1.

16.2.2    A Finance Party is not obliged to take any steps under Clause 16.1 if,
          in the opinion of that Finance Party (acting reasonably), to do so
          might be prejudicial to it.

17        COSTS AND EXPENSES

17.1      TRANSACTION EXPENSES


          The Parent shall promptly on demand pay the Agent and the Arranger the
          amount of all costs and expenses (including legal fees) reasonably
          incurred by any of them in connection with the negotiation,
          preparation, printing, execution and syndication of:

          (a)       this Agreement and any other documents referred to in this
                    Agreement; and



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          (b)       any other Finance Documents executed after the date of this
                    Agreement.

17.2      AMENDMENT COSTS


          If:

          (a)       an Obligor requests an amendment, waiver or consent; or

          (b)       an amendment is required pursuant to Clause 30.9,


          the Parent shall, within three Business Days of demand, reimburse the
          Agent for the amount of all costs and expenses (including legal fees)
          reasonably incurred by the Agent in responding to, evaluating,
          negotiating or complying with that request or requirement.

17.3      ENFORCEMENT COSTS


          The Parent shall, within three Business Days of demand, pay to each
          Finance Party the amount of all costs and expenses (including legal
          fees) incurred by that Finance Party in connection with the
          enforcement of, or the preservation of any rights under, any Finance
          Document.

18        GUARANTEE AND INDEMNITY

18.1      GUARANTEE AND INDEMNITY


          Each Guarantor irrevocably and unconditionally jointly and severally:

          (a)       guarantees to each Finance Party or (in the case of Canada
                    Holdco and any other Canadian Guarantor from time to time
                    only) the Security Trustee punctual performance by each
                    Borrower of all that Borrower's obligations under the
                    Finance Documents;

          (b)       undertakes with each Finance Party that whenever a Borrower
                    does not pay any amount when due under or in connection with
                    any Finance Document, that Guarantor shall immediately on
                    demand pay that amount as if it was the principal obligor;
                    and

          (c)       undertakes to indemnify each Finance Party immediately on
                    demand against any cost, loss or liability suffered by that
                    Finance Party if any obligation guaranteed by it is or
                    becomes unenforceable, invalid or illegal. The amount of the
                    cost, loss or liability shall be equal to the amount which
                    that Finance Party would otherwise have been entitled to
                    recover.


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18.2      CONTINUING GUARANTEE


          This guarantee is a continuing guarantee and will extend to the
          ultimate balance of sums payable by any Obligor under the Finance
          Documents, regardless of any intermediate payment or discharge in
          whole or in part.

18.3      REINSTATEMENT


          If any payment by an Obligor or any discharge given by a Finance Party
          (whether in respect of the obligations of any Obligor or any security
          for those obligations or otherwise) is avoided or reduced as a result
          of insolvency or any similar event:

          (a)       the liability of each Obligor shall continue as if the
                    payment, discharge, avoidance or reduction had not occurred;
                    and

          (b)       each Finance Party shall be entitled to recover the value or
                    amount of that security or payment from each Obligor, as if
                    the payment, discharge, avoidance or reduction had not
                    occurred.

18.4      WAIVER OF DEFENCES


          The obligations of each Guarantor under this Clause 18 will not be
          affected by an act, omission, matter or thing which, but for this
          Clause, would reduce, release or prejudice any of its obligations
          under this Clause 18 (without limitation and whether or not known to
          it or any Finance Party) including:

          (a)       any time, waiver or consent granted to, or composition with,
                    any Obligor or other person;

          (b)       the release of any other Obligor or any other person under
                    the terms of any composition or arrangement with any
                    creditor of any member of the Group;

          (c)       the taking, variation, compromise, exchange, renewal or
                    release of, or refusal or neglect to perfect, take up or
                    enforce, any rights against, or security over assets of, any
                    Obligor or other person or any non-presentation or
                    non-observance of any formality or other requirement in
                    respect of any instrument or any failure to realise the full
                    value of any security;

          (d)       any incapacity or lack of power, authority or legal
                    personality of or dissolution or change in the members or
                    status of an Obligor or any other person;

          (e)       any amendment (however fundamental) or replacement of a
                    Finance Document or any other document or security;

          (f)       any unenforceability, illegality or invalidity of any
                    obligation of any person under any Finance Document or any
                    other document or security; or

          (g)       any insolvency or similar proceedings.


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18.5      IMMEDIATE RECOURSE


          Each Guarantor waives any right it may have of first requiring any
          Finance Party (or any trustee or agent on its behalf) to proceed
          against or enforce any other rights or security or claim payment from
          any person before claiming from that Guarantor under this Clause 18.
          This waiver applies irrespective of any law or any provision of a
          Finance Document to the contrary.

18.6      APPROPRIATIONS


          Until all amounts which may be or become payable by the Obligors under
          or in connection with the Finance Documents have been irrevocably paid
          in full, each Finance Party (or any trustee or agent on its behalf)
          may:

          (a)       refrain from applying or enforcing any other moneys,
                    security or rights held or received by that Finance Party
                    (or any trustee or agent on its behalf) in respect of those
                    amounts, or apply and enforce the same in such manner and
                    order as it sees fit (whether against those amounts or
                    otherwise) and no Guarantor shall be entitled to the benefit
                    of the same; and

          (b)       hold in an interest-bearing suspense account any moneys
                    received from any Guarantor or on account of any Guarantor's
                    liability under this Clause 18.

18.7      DEFERRAL OF GUARANTORS' RIGHTS


          Until all amounts which may be or become payable by the Obligors under
          or in connection with the Finance Documents have been irrevocably paid
          in full and unless the Agent otherwise directs, no Guarantor will
          exercise any rights which it may have by reason of performance by it
          of its obligations under the Finance Documents:

          (a)       to be indemnified by an Obligor;

          (b)       to claim any contribution from any other guarantor of any
                    Obligor's obligations under the Finance Documents; and/or

          (c)       to take the benefit (in whole or in part and whether by way
                    of subrogation or otherwise) of any rights of the Finance
                    Parties under the Finance Documents or of any other
                    guarantee or security taken pursuant to, or in connection
                    with, the Finance Documents by any Finance Party.

18.8      ADDITIONAL SECURITY


          This guarantee is in addition to and is not in any way prejudiced by
          any other guarantee or security now or subsequently held by any
          Finance Party.

19        REPRESENTATIONS

          Each Obligor makes the representations and warranties set out in this
          Clause 19 to each Finance Party on the date of this Agreement.


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19.1      STATUS

19.1.1    It is a corporation, duly incorporated and validly existing under the
          law of its jurisdiction of incorporation.

19.1.2    It and each other Material Company has the power to own its assets and
          carry on its business as it is being conducted.

19.2      POWER AND AUTHORITY

          Each Obligor has power to execute, deliver and perform its obligations
          under the Transaction Documents to which it is a party; all necessary
          corporate, shareholder or other action has been taken to authorise the
          execution, delivery and performance of such Transaction Documents and
          no limitation on the powers of any such Obligor or its Directors shall
          be exceeded as a result of the drawdown of the Loan or the utilisation
          of the Facilities.

19.3      BINDING OBLIGATIONS


          The Transaction Documents constitute legal, valid and binding
          obligations of each Obligor which is a party to them and are
          enforceable (subject to the Reservations), in accordance with their
          respective terms.

19.4      NON-CONFLICT WITH OTHER OBLIGATION


          The entry into and performance of the terms and conditions of the
          Transaction Documents by each relevant Obligor do not and shall not
          contravene or conflict with its memorandum and articles of
          association, any law, statute, rule, regulation, judgement, decree or
          other instrument binding on it or any of its assets, or any agreement
          or document to which it is a party or is binding on it or any of its
          assets and all acts, conditions and things required to be done,
          fulfilled and performed in order:

          (a)       to enable it lawfully to enter into, exercise its rights
                    under and perform the obligations expressed to be assumed by
                    it in the Transaction Documents; and

          (b)       to ensure that the obligations expressed to be assumed by it
                    in the Transaction Documents are legal, valid and binding,
                    have been undertaken;

19.5      NO DEFAULT

19.5.1    No Material Company is (nor with the giving of notice, lapse of time
          or satisfaction of any other condition would be) in breach of or in
          default under any agreement or document to which it is a party or by
          which it or any part of its assets may be bound which would have a
          Material Adverse Effect;

19.5.2    No Event of Default, Default or Mandatory Prepayment Event has
          occurred.

19.6      NO PROCEEDINGS PENDING OR THREATENED


          No action, litigation, arbitration or administrative proceeding is
          taking place, pending or so far as each Obligor is aware having made
          all appropriate enquiries threatened against any Material Company or
          any part of their respective

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          undertakings, assets or revenues which is, in the reasonable opinion
          of the Agent, likely to be adversely determined and if adversely
          determined is likely to have a Material Adverse Effect;

19.7      NO SECURITY


          No Material Company has assets which are affected by any Security, nor
          is any such company a party to, nor is it or any of its assets bound
          by, any order, agreement or instrument under which it is, or may be,
          required to create, assume or permit to arise any Security, other than
          in each case any Permitted Security Interest;

19.8      CORPORATE STRUCTURE


          The corporate structure of the Group following Closing and before the
          Intra Group Transfer shall be as set out in Schedule 12 and (other
          than the Overseas Companies) each Group Company is resident in the
          United Kingdom for tax purposes;

19.9      NO BORROWINGS


          No Group Company has any Financial Indebtedness save for Permitted
          Financial Indebtedness;

19.10     BUSINESS PLAN

19.10.1   All statements of fact recorded in the Business Plan are true and
          accurate in all material respects; the opinions and views expressed in
          the Business Plan represent the honestly held opinions and views of
          the Parent and Management Team and were arrived at after careful
          consideration and are based on reasonable grounds; the projections and
          forecasts contained in the Business Plan are based upon assumptions
          (including assumptions as to the future performance of the Target
          Group, inflation, price increases, interest rates and efficiency
          gains) which the Parent and Management Team have carefully considered
          and considered to be fair and reasonable; the Business Plan is not
          misleading in any material respect and does not omit to disclose any
          matter where failure to disclose such matter would result in the
          Business Plan (or any information or projection contained therein) to
          be misleading in any material respect; and nothing has occurred or
          come to light since the date as at which the Business Plan was
          prepared which renders any material facts contained in the Business
          Plan inaccurate or misleading or which makes any of the opinions,
          projections or forecasts contained therein other than fair and
          reasonable or renders any of the assumptions upon which the
          projections are based other than fair and reasonable;

19.11     REPORTS


          All written information supplied by or on behalf of the Parent and by
          their respective agents and advisers in connection with this Agreement
          and the preparation of the Reports was true, complete and accurate in
          all material respects at the dates supplied (or, if not, has
          subsequently been corrected and such correction is reflected in the
          Reports), all statements of fact recorded in the Reports are true and
          accurate in all material respects; none of the Reports (or any part
          thereof) is misleading in any material respect and there is no
          expression of opinion, forecast or projection contained in the Reports
          or any conclusion reached therein in relation to any material matter
          which is not fair and reasonable in all material respects so far as
          the Parent is or ought to be aware of having made due and diligent
          enquiries of the

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          Management Team and all other relevant parties and there is no such
          opinion, forecast, projection or conclusion with which any of the
          Management Team or any other director of the Parent disagrees in any
          material respect; and nothing has occurred or come to light since the
          date of any Report which renders any material facts contained in that
          Report inaccurate or misleading or which makes any of the opinions,
          projections, forecasts or conclusions contained in the relevant Report
          other than fair and reasonable;

19.12     TRANSACTION DOCUMENT REPRESENTATIONS


          All representations and warranties made by or on behalf of the Parent
          in the Merger Documents and Equity Documents are true and accurate in
          all material respects; and to the best of the Parent's knowledge and
          belief (having held discussions with the Chief Financial Officer of
          Target, the Chief Executive Officer of Clintrials BioResearches
          Limited and the Chief Financial Officer of Clintrials BioResearches
          Limited) all representations and warranties made by or on behalf of
          any Target Group Company in Merger Agreement are true and complete in
          all material respects;

19.13     TARGET ACCOUNTS


          To the best of the knowledge and belief of the Parent having held
          discussions with the Chief Financial Officer of the Target Group, the
          Target Accounts and Target Management Accounts were prepared in
          accordance with GAAP consistently applied and fairly presented the
          results of the operations of the Target Group for the periods to which
          they relate and the state of the affairs of the Target Group at the
          end of such period and, in particular, disclose or reserve against all
          liabilities (actual or contingent) of the Target Group to the extent
          required by GAAP and there are no material liabilities (whether
          actual, contingent, present or future) which are not disclosed or
          shown as being provided for in the relative Target Accounts and/or
          Target Management Accounts and which have not been disclosed or
          referred to in the Accountant's Report or, where they have arisen
          after the date of the Accountant's Report have not been disclosed in
          writing to the Lenders;

19.14     TAXES


          All necessary returns have been delivered by or on behalf of each
          Material Company to the relevant taxation authorities and no such
          member is in default in the payment of any Taxes taking into account
          any grace periods and no claim is being asserted with respect to Tax
          which is not disclosed in its latest published financial statements;

19.15     INTELLECTUAL PROPERTY RIGHTS


          Each Material Company owns all necessary Intellectual Property Rights
          and such information systems and equipment as are required by it in
          order for it to carry on its business and no notification has been
          received or is anticipated to be received alleging infringement of any
          such rights; all such rights are free from Security Interests (other
          than the Permitted Security Interests), are not subject to the rights
          of any other party and so far as the Parent is aware are not presently
          being infringed by any person;


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19.16     ENVIRONMENTAL


          No Material Company has infringed, or received any claim in respect
          of, any provision of Environmental Law or any Environmental Licence
          which would or would be reasonably likely to have Material Adverse
          Effect;

19.17     ERISA

19.17.1   As of the Closing Date, no Borrower, nor any Group Company, nor any
          ERISA Affiliate maintains or contributes to, or has any obligation
          under, any Employee Benefit Plans other than those identified on
          Schedule 6.1(I) hereto;

19.17.2   Each Borrower, each Group Company and each ERISA Affiliate is in
          compliance with all applicable provisions of ERISA and the regulations
          and published interpretations thereunder with respect to all Employee
          Benefit Plans except for any required amendments for which the
          remedial amendment period as defined in Section 401(b) of the Code has
          not yet expired. Each Employee Benefit Plan that is intended to be
          qualified under Section 401(a) of the Code has been determined by the
          Internal Revenue Service to be so qualified, and each trust related to
          such plan has been determined to be exempt under Section 501(a) of the
          Code. No liability has been incurred by any Borrower, any Group
          Company or any ERISA Affiliate which remains unsatisfied for any taxes
          or penalties with respect to any Employee Benefit Plan or any
          Multiemployer Plan;

19.17.3   No Pension Plan has been terminated, nor has any accumulated funding
          deficiency (as defined in Section 412 of the Code) been incurred
          (without regard to any waiver granted under Section 412 of the Code),
          nor has any funding waiver from the Internal Revenue Service been
          received or requested with respect to any Pension Plan, nor has any
          Borrower, any Subsidiary or any ERISA Affiliate failed to make any
          contributions or to pay any amounts due and owing as required by
          Section 412 of the Code, Section 302 of ERISA or the terms of any
          Pension Plan prior to the due dates of such contributions under
          Section 412 of the Code or Section 302 of ERISA, nor has there been
          any event requiring any disclosure under Section 4041(c)(3)(C) or
          4063(a) of ERISA with respect to any Pension Plan;

19.17.4   No Borrower, Group Company or ERISA Affiliate has:

          (a)       engaged in a nonexempt prohibited transaction described in
                    Section 406 of the ERISA or Section 4975 of the Code;

          (b)       incurred any liability to the PBGC which remains outstanding
                    other than the payment of premiums and there are no premium
                    payments which are due and unpaid;

          (c)       failed to make a required contribution or payment to a
                    Multiemployer Plan; or

          (d)       failed to make a required instalment or other required
                    payment under Section 412 of the Code;

19.17.5   No Termination Event has occurred or is reasonably expected to occur;
          and


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19.17.6   No proceeding, claim, lawsuit and/or investigation is existing or, to
          the best knowledge of each Borrower and each Group Company after due
          inquiry, threatened, concerning or involving any:

          (a)       employee welfare benefit plan (as defined in Section 3(1) of
                    ERISA) currently maintained or contributed to by any
                    Borrower, any Group Company or any ERISA Affiliate;

          (b)       Pension Plan; or

          (c)       Multiemployer Plan.


19.18     LICENCES


          All licences, consents, exemptions, clearances, filings,
          registrations, payments of duties or taxes, notarisations and
          authorisations as are or may be necessary or desirable for the proper
          conduct of its business, trade and ordinary activities and for the
          performance and discharge of its obligations and liabilities under
          each of the Transaction Documents and which are required in connection
          with the execution, delivery, validity, enforceability or
          admissibility in evidence of each of the Transaction Documents are in
          full force and effect where failure would be reasonably likely to have
          Material Adverse Effect;

19.19     MATERIAL FACTS

19.19.1   There are no material facts known to the Parent which if disclosed
          would be reasonably likely to affect the decision of a prudent lender
          whether or not to make facilities available to the Parent on the terms
          of this Agreement and:

          (a)       so far as the Parent is aware having had discussions with
                    the Management Team since the date to and as at which the
                    Target Accounts were made up, there has been no material
                    adverse change in the business, assets, financial
                    conditions, prospects or operations of the Target Group; and

          (b)       so far as the Parent is aware having held discussions with
                    the Management Team since the date to and as at which the
                    Target Management Account were made up there has been no
                    material adverse change in the business, assets, financial
                    conditions, prospects or operation of the Target Group;

19.20     FINANCIAL STATEMENTS

19.20.1   Its Original Financial Statements were prepared in accordance with
          GAAP consistently applied.

19.20.2   Its Original Financial Statements give a true and fair view of its
          financial condition and operations (consolidated in the case of the
          Parent) during the relevant financial period.

19.20.3   There has been no material adverse change in its business or financial
          condition (or the business or consolidated financial condition of the
          Group, in the case of the Parent) since the date to which its most
          recent unaudited annual financial statements were prepared


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19.21     MERGER

19.21.1   So far as the Parent is aware, no breach of any of the representations
          given by Target in the terms of the Merger Agreement (breach of which
          would have a Material Adverse Effect) has occurred.

19.21.2   The Parent and US Newco each has the power and authority under the
          laws of its state of incorporation and under its articles of
          incorporation and by-laws to enter into and perform the Merger
          Agreement (to which each is a party, respectively) and all other
          agreements, documents and actions required thereunder; and all actions
          (corporate or otherwise) necessary or appropriate for the execution
          and performance by each Parent and US Newco of the Share Purchase and
          the Merger Agreement (to which each is a party, respectively) and all
          other documents, agreements and actions required thereunder have been
          taken.

19.21.3   The making and performance of the Merger Agreement and all other
          agreements, documents and actions required thereunder, will not
          violate any provision of any law or regulation, federal, state or
          local, and will not violate any provisions of the articles of
          incorporation and by-laws of any of Parent or US Newco, or constitute
          a default under any agreement by which Parent or US Newco or its
          respective property may be bound which default would have a Material
          Adverse Effect .

19.22     MARGIN STOCK


          No Borrower or Group Company is engaged principally or as one of its
          activities in the business of extending credit for the purpose of
          purchasing or carrying any margin stock (as each such term is defined
          or used in Regulation U of the Board of Governors of the Federal
          Reserve System). No part of the proceeds of any of the Loans will be
          used for purchasing or carrying margin stock or for any purpose which
          violates, or which would be inconsistent with, the provisions of
          Regulation T, U or X of such Board of Governors.

19.23     SOLVENCY


          Excluding intercompany indebtedness, each Material Company
          incorporated in any state of the USA is, and after receipt and
          application of the first advance under this Agreement will be, solvent
          such that:

          (a)       the fair value of its assets (including without limitation
                    the fair saleable value of the goodwill and other intangible
                    property of such Material Company) is greater than the total
                    amount of its liabilities, including without limitation,
                    contingent liabilities;

          (b)       the present fair saleable value of its assets (including
                    without limitation the fair saleable value of the goodwill
                    and other intangible property of such Material Company) is
                    not less than the amount that will be required to pay the
                    probable liability on their debts as they become absolute
                    and matured; and

          (c)       they are able to realise upon their assets and pay their
                    debts and other liabilities, contingent obligations and
                    other commitments as they mature in the normal course of
                    business. No Material Company intends to, nor believes that
                    it will, incur debts or liabilities beyond its ability to
                    pay as such debts and liabilities mature, and no Material
                    Company is engaged in

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                    a business or transaction, or about to engage in a business
                    or transaction, for which its property would constitute
                    unreasonably small capital after giving due consideration to
                    the prevailing practice and industry in which it is engaged.
                    For purposes of this Clause, in computing the amount of
                    contingent liabilities at any time, it is intended that such
                    liabilities will be computed at the amount which, in light
                    of all the facts and circumstances existing at such time,
                    represents the amount that reasonably can be expected to
                    become an actual matured liability of the applicable
                    Material Company.

19.24     REPETITION


          The Repeating Representations are deemed to be made by each Obligor by
          reference to the facts and circumstances then existing on:

          (a)       the date of each Utilisation Request and the first day of
                    each Interest Period;

          (b)       the date of each Utilisation of the Working Capital
                    Facility; and

          (c)       in the case of an Additional Obligor, the day on which it
                    becomes (or it is proposed that it becomes) an Additional
                    Obligor.

19.25     LIMITATION DURING AVAILABILITY PERIOD


          No representation or warranty in any Finance Document will be given or
          deemed repeated pursuant to Clause 19.24 during the Availability
          Period except the Primary Warranties prior to the Drawdown Date.

20        INFORMATION UNDERTAKINGS


          The undertakings in this Clause 20 remain in force from the date of
          this Agreement for so long as any amount is outstanding under the
          Finance Documents or any Commitment is in force.

20.1      FINANCIAL INFORMATION


          The Parent undertakes to supply to the Agent (unless the Agent acting
          on the instruction of the Lenders otherwise agrees) in sufficient
          copies for the Lenders:-

          (a)       as soon as they become available but in any event within 90
                    days after the end of each of its financial years its
                    audited consolidated financial statements for that financial
                    year and the audited financial statements of each Material
                    Company for that financial year together with a Compliance
                    Certificate; from the directors of the Parent;

          (b)       as soon as they become available but in any event no later
                    than 30 days after the end of each successive Management
                    Accounting Period consolidated Management Accounts for that
                    Management Accounting Period, the Management Accounts of
                    each Material Company for that Management Accounting Period
                    and aggregated (in Sterling) Management Accounts for the
                    Ringfenced Group for that Management Accounting Period
                    together with a Compliance Certificate from the directors of
                    the Parent;


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          (c)       not later than 30 days prior to the beginning of each
                    financial year, an Operating Budget for the Group and an
                    Operating Budget for the Ringfenced Group in respect of the
                    financial year about to commence in a form and content
                    satisfactory to the Agent;

          (d)       as it becomes available but in any event not later than 90
                    days after the end of each financial year a certificate from
                    the financial director of the Parent or (if the Agent in the
                    exercise of its sole discretion so determines) Auditors
                    addressed to the Agent and the Lenders and in a form
                    acceptable to the Agent certifying (with supporting
                    calculations) the Parent's compliance (or otherwise) with
                    the financial covenants in Clause 21;

          (e)       promptly send such further information in its possession
                    regarding the financial condition and operation of the Group
                    as the Agent may reasonably request.

20.2      FINANCIAL STATEMENTS


          The Parent undertakes to ensure that all financial statements
          contemplated by Clause 20.1(a) and (b) shall be prepared in accordance
          with GAAP, consistently applied, and that all financial statements
          contemplated by Clause 20.1(a) are prepared in accordance with the
          Companies Act 1985 and show a true and fair view of the state of
          affairs of the relevant company and (in the case of the consolidated
          accounts) of the Group as at the date of the same.

20.3      INVESTIGATION


          The Parent hereby agrees that:

          (a)       following such period of discussion, if any, with the
                    finance director of the Parent as the Agent in its sole
                    discretion deems appropriate, it will if so required by the
                    Agent who believes in good faith that either:

                    (i)       any financial statements or calculations provided
                              by the Parent are inaccurate or incomplete in any
                              material respect; or

                    (ii)      the financial performance of the Group may give
                              rise (or has given rise) to a breach of one or
                              more of the financial covenants in Clause 21)


                    at the expense of the Parent (provided all such expenses are
                    estimated for the Parent in advance and properly incurred)
                    instruct the Auditors or other firm of accountants of
                    international repute selected by the Parent to discuss the
                    financial position of the Group with the Agent and to
                    disclose to the Agent (and provide that Agent with copies
                    of) such information as the Agent may reasonably request
                    regarding the financial condition and business of the Parent
                    and any of its Subsidiaries; and

          (b)       if, having taken the steps in 20.3(a) above, the Agent
                    acting in good faith continues to have concerns in relation
                    to the financial performance of the Group, the accuracy of
                    information provided by any member of the Group or
                    compliance with the financial covenants in Clause 21 or any
                    other legitimate concern relating to the affairs of the
                    Group, the Agent may instruct the Auditors or other firm of
                    accountants selected by the Agent to

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                    carry out an investigation at the Parent's expense (provided
                    all such expenses are estimated for the Parent in advance
                    and properly incurred) into the affairs of the Group and/or
                    the financial performance of the Group and/or the accounting
                    and other reporting procedures and standards of the Group
                    and the Parent will procure that full co-operation is given
                    to the Auditors or other firm of accountants so selected.

21        FINANCIAL COVENANTS

21.1      COVENANTS


          The Parent undertakes to and covenants with the Agent as follows:

21.1.1    The Parent undertakes that, except as hereinafter provided during the
          Security Period, the Ringfenced Group shall comply with the following
          financial undertakings which will be calculated in accordance with the
          provisions of this Clause 21 in each case by reference to the relative
          financial statements.

21.1.2    Aggregated Minimum Net Worth of the Ringfenced Group shall not during
          each period set out in Column A be less than the figure set out
          opposite that period in Column B:-




      COLUMN A                                                          COLUMN B
      (PERIOD)                                                            L000
- --------------------------------------------------------------------------------
                                                                    
Drawdown Date to 31 May 2001                                             69,000
1 June 2001 to 31 July 2001                                              72,000
1 August 2001 to 31 October 2001                                         74,000
1 November 2001 to 31 December 2001                                      77,000
1 January 2002 to 31 March 2002                                          78,000
1 April 2002 to 30 June 2002                                             80,000
1 July 2002 to 30 September 2002                                         82,000
1 October 2002 to 31 December 2002                                       85,000
1 January 2003 to 30 April 2003                                          88,000
1 May 2003 to 31 July 2003                                               90,000
1 August 2003 to 31 October 2003                                         93,000
1 November 2003 to 31 December 2003                                      96,000
each quarterly period thereafter                                        100,000


21.1.3    The ratio of Ringfenced PBITDA to Ringfenced Total Interest during
          each period set out in Column A below shall be not less than the ratio
          set out in Column B opposite for that period:-


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                COLUMN A                                                COLUMN B
                (PERIOD)                                                 (RATIO)
- --------------------------------------------------------------------------------
                                                                    
Drawdown date to 30 September 2001                                         3.1:1
Drawdown date to 31 December 2001                                          3.2:1
31 March 2001 to 31 March 2002                                             3.3:1
30 June 2001 to 30 June 2002                                               3.4:1
30 September 2001 to 30 September 2002                                     3.4:1
31 December 2001 to 31 December 2002                                       3.5:1
31 March 2002 to 31 March 2003                                             3.7:1
30 June 2002 to 30 June 2003                                               3.9:1
30 September 2002 to 30 September 2003                                     4.2:1
31 December 2002 to 31 December 2003                                       4.4:1
each twelve month period thereafter                                        5.0:1
beginning on 31 March, 30 June, 30
September, 31 December


21.1.4    The ratio of Cashflow to Debt Service during each period set out in
          Column A below shall not be less than the ratio indicated in Column B
          opposite for that period:-




                 COLUMN A                                               COLUMN B
                (PERIOD)                                                 (RATIO)
- --------------------------------------------------------------------------------
                                                                     
Drawdown Date to 31 December 2001                                            1:1
each twelve month period thereafter                                          1:1
beginning on 31 March, 30 June, 30
September and 31 December


21.1.5    The ratio of Senior Debt to Ringfenced PBITDA during each period set
          out in Column A below shall be not more than the ratio set out in
          Column B opposite for that period:-



                 COLUMN A                                               COLUMN B
                 (PERIOD)                                                (RATIO)
- --------------------------------------------------------------------------------
                                                                     
Drawdown date to 31 December 2001                                         5.1:1
31 March 2001 to 31 March 2002                                            3.75:1
30 June 2001 to 30 June 2002                                              3.5:1
30 September 2001 to 30 September 2002                                    3.5:1
31 December 2001 to 31 December 2002                                      3.25:1
31 March 2002 to 31 March 2003                                            3.2:1
30 June 2002 to 30 June 2003                                              2.9:1
30 September 2002 to 30 September 2003                                    2.75:1
31 December 2002 to 31 December 2003                                      2.5:1
each twelve month period thereafter                                       2.5:1
beginning on 31 March, 30 June, 30
September and 31 December



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21.1.6    The financial covenants set out above shall be tested as follows:

          (a)       the financial covenant in Clauses 21.1.2 shall be tested on
                    a monthly basis; and

          (b)       the financial covenants in Clauses 21.1.3, 21.1.5 and 21.1.4
                    shall be tested on a quarterly basis.

21.1.7    All financial covenants shall be tested by reference to the latest
          audited financial statements of the members of the Ringfenced Group
          or, if more recent, by reference to the latest aggregated Management
          Accounts of the Ringfenced Group provided that where any financial
          covenant is tested by reference to year end Management Accounts it
          shall be tested again by reference to the audited financial statements
          of the members of the Ringfenced Group for the relevant period when
          those audited financial statements become available.

21.1.8    In the event that the Parent is in default or breach of any of the
          financial covenants contained in this Clause 21.1, the Agent shall be
          entitled to make such investigations and obtain such legal,
          accountancy and/or valuation reports as it shall deem appropriate at
          the cost of the Parent and the Borrower and each Group Company shall
          provide all assistance required in connection with such investigations
          and reports.

21.1.9    The calculation of the financial covenants detailed in Clause 21.1
          shall be carried out by the Agent in accordance with the accounting
          principles and policies applied in the most recent audited financial
          statements and/or Management Accounts to which it is referring.

21.1.10   If the Parent changes the accounting policies applied, whether as a
          result of a change in GAAP or otherwise, in a way that affects the
          financial covenants detailed in this Clause 21.1 the Agent shall be
          entitled to recalculate such covenants (following such period of
          discussion, if any, with the finance director of the Parent as the
          Agent in its sole discretion considers appropriate in the
          circumstances) as if such changes had not taken place.

21.1.11   If there is any dispute as to any computation under Clause 21.1.7 or
          Clause 21.1.8 or as to the interpretation of any of the relevant
          definitions set out herein, the decision of the Agent (acting on the
          instructions of the Lenders) shall, in the absence of manifest error
          be conclusive and binding on each Borrower.

21.1.12   For the purposes of this Agreement and this Clause 21.1 in particular,
          the following expressions shall have the following meanings (unless
          the context otherwise requires):-


          "AGGREGATED MINIMUM NET WORTH" means the aggregate of the amount
          (including any share premium) for the time being paid up or credited
          as paid up on the issued share capital of the Parent at the time of
          calculation:


          PLUS      the amount standing to the credit (or, as the case may be,
                    MINUS the amount standing to the debit) of the aggregate
                    profit and loss account as reflected in the aggregated
                    balance sheet of the Ringfenced Group as at the end of the
                    latest accounting reference period for which aggregated
                    accounts of the Group have been (or are required to have
                    been) delivered to the Agent;


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          PLUS      any other aggregated reserves of the Ringfenced Group (but
                    excluding any positive revaluation reserve derived from any
                    writing up of book value of any assets of any member of the
                    Ringfenced Group above historic cost less accumulated
                    depreciations after Drawdown Date and any capital reserve
                    reflecting a pension fund surplus);


          PLUS      the amount of any goodwill written off (to the extent
                    written off against capital and revenue reserves of the
                    Ringfenced Group) or amortised;


          PLUS      an amount equal to the principal amount of the Loan Stock
                    together with any amounts of interest thereon which are
                    rolled up under the terms of the Loan Stock Instrument or by
                    resolution of the holders thereof (in each case so that such
                    interest is not payable until the end of the period to which
                    they relate) and any amounts of such interest which are
                    capitalised and issued as additional Loan Stock under the
                    Loan Stock Instrument;


          PLUS      an amount equal to the amount of all transaction costs in
                    relation to the Merger and its financing only to the extent
                    written off directly to reserves;


          MINUS     any amount which is attributable to:

                    (a)       titles, trademarks, copyrights, patents,
                              capitalised research and development expenditure,
                              capitalised redundancy and closure costs and other
                              intangible assets; and

                    (b)       deferred taxation (save to the extent that this
                              would result in the relevant deferred taxation
                              being effectively deducted more than once in any
                              determination of Aggregated Minimum Net Worth);


          MINUS     from profit before tax for the period a notional tax charge
                    at such rate as may be payable by the Parent from time to
                    time;


          MINUS     from profit after tax for the period Distributions paid or
                    payable in respect of that period;


          MINUS     any reserves or capital of the Group created by any surplus
                    on the sale of any investment or other asset (excluding
                    trading stock) of the Group;


          MINUS     (to the extent otherwise included) the amount attributable
                    to the interests (if any) of the outside holders of issued
                    share capital in any member of the Group other than the
                    Parent;


          For the purposes of the foregoing, all items shall be calculated on an
          aggregated basis and in accordance with applicable accounting
          principles and, where the calculation is being made at the end of any
          accounting reference period for which an aggregated balance sheet of
          the Group has been or is required to be delivered to the Agent, shall
          be as shown in that balance sheet;


          "CASHFLOW" means in relation to any period, Ringfenced PBITDA for that
          period adjusted as follows:-

          (a)       adding back any other non-cash charges and deducting any
                    other non-cash income, as the case may be, to the extent
                    already taken into account in Ringfenced PBITDA;


                                       71
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          (b)       deducting any profit, or adding any loss, as the case may
                    be, from the disposal of fixed assets, to the extent already
                    taken into account in Ringfenced PBITDA;

          (c)       adding any increase or deducting any decrease as the case
                    may be, in Current Liabilities;

          (d)       adding any decrease or deducting any increase, as the case
                    may be in Current Assets;

          (e)       adding the proceedings of the disposal of any fixed assets;

          (f)       adding the proceeds of any issue of shares in the Parent;

          (g)       adding any payments received in respect of Tax rebates;

          (h)       deducting Corporation Tax paid;

          (i)       deducting all amounts paid in respect of Capital Expenditure
                    excluding that funded under Finance Leases or under the
                    Capital Expenditure Facility;

          (j)       deducting any expenditure on the acquisition of share
                    capital in any third party;

          (k)       deducting all amounts paid in respect of any loans made by
                    any Group Company to any third party;

          (l)       deducting any exceptional or extraordinary expenditure and
                    adding any exceptional or extraordinary receipts;

          (m)       adding the proceeds of any subscription for shares or
                    additional Loan Stock (or other subordinated loan capital,
                    in the capital of, or issued by the Parent) to the extent
                    such proceeds are received in cash by the Parent in the
                    relevant period;

          (n)       adding any transaction costs in relation to the Merger and
                    its financing to the extent deducted from Ringfenced PBITDA,


          but without double counting in any case;


          "CURRENT ASSETS" means, in relation to each Ringfenced Group Member at
          any time, the aggregate value of its assets which are treated as
          current assets in accordance with GAAP;


          "CURRENT LIABILITIES" means, in relation to each Ringfenced Group
          Member at any time, the aggregate value of its liabilities which are
          treated as current liabilities in accordance with GAAP;


          "DEBT SERVICE" means, in relation to any relevant period, the
          aggregate of the following items:

          (a)       Aggregated Total Interest paid (including interest actually
                    paid on Loan Stock (other than issuance of additional Loan
                    Stock) but excluding any interest rolled up under the terms
                    of the Loan Stock or (unless the direct or

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                    indirect effect of such exclusion would be that it would no
                    longer be prohibited from being paid (in which case it shall
                    be included)) by the Intercreditor Agreement);

          (b)       Distributions declared or paid during that period;

          (c)       repaying of Borrowings made or due within that period (but
                    excluding any prepayments pursuant to Clause 8.7);

          (d)       the amount paid in respect of redemption of any shares or
                    Loan Stock by the Parent during that period; and

          (e)       capital payments under Finance Leases;


          "RINGFENCED PBITDA" means for any period, the aggregated profit of the
          Ringfenced Group before extraordinary and exceptional items (as
          defined by Statement of Standard Accounting Practice No 6 and
          Financial Report Standard No 3, both as amended or updated from time
          to time), Taxation and interest accrued during such period as an
          obligation of or owed to any member or members of the Ringfenced
          Group, whether or not paid, deferred or capitalised during such period
          and excluding, any gain on the revaluation of any assets (other than
          sale or other disposal of trading stock and work in progress) of the
          Ringfenced Group for such period, calculated on a consolidated basis
          and (subject only as may be required in order to reflect the express
          inclusion or exclusion of items as specified in this definition) in
          accordance with the applicable accounting principles and determined
          from the aggregated financial statements of the Ringfenced Group for
          such period adjusted as follows:-

          (a)       before depreciation of fixed assets (excluding any
                    additional depreciation arising from the write-up of the
                    book value of assets);

          (b)       before any charge for the amortisation of goodwill or any
                    other intangible assets; and

          (c)       excluding provisions (other than provisions for stock and
                    trade debtors) made before the Drawdown Date which have been
                    subsequently written back;

          (d)       before taking into account earnings or losses attributable
                    to Affiliates (other than to the extent earnings are
                    received in cash by a member of a Group);

          (e)       adding back an amount equal to the amount of all transaction
                    costs in relation to the Merger and its financing to the
                    extent deducted from such profits;


          "RINGFENCED TOTAL INTEREST" for any relevant period means the
          aggregate (calculated on an aggregated basis) of all interest, amounts
          in the nature of interest, commitment commission, guarantee fees and
          the interest element of Finance Leases incurred, paid or accrued in
          respect of Borrowings during such period as an obligation of any
          Ringfenced Group Member, other than, unless otherwise expressly
          stated:

          (a)       the Loan Stock; and


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          (b)       arrangement fees charged during such period;


          "SENIOR DEBT" means, in respect of the last day of each period set out
          in Column A in Clause 21.1.5, Series 1 Term Facility Loans, Series 2
          Term Facility Loans, Capital Expenditure Facility Loans and
          Utilisations of the Working Capital Facility outstanding on such date.

21.2      EXCHANGE RATE ADJUSTMENT


          The Lenders acknowledge that the terms of this Clause 21 have been
          agreed on the basis of the exchange rates set out in the Business Plan
          and that in the event that the Parent is able to demonstrate to the
          satisfaction of the Finance Parties (acting reasonably) that any
          breach of Clause 21.1 has arisen solely as a result of a movement in
          any exchange rates after the date of this Agreement, the Finance
          Parties will instruct the Agent to negotiate in good faith with the
          Parent to agree replacement financial covenants which provide the
          Finance Parties with equivalent protection to that offered by the
          financial covenants set out in Clause 21 as at the date of this
          Agreement.

22        GENERAL UNDERTAKINGS


          The undertakings in this Clause 22 remain in force from the Drawdown
          Date for so long as any amount is outstanding under the Finance
          Documents or any Commitment is in force.

22.1      POSITIVE UNDERTAKINGS

22.1.1    USE OF FACILITIES


          The Parent shall use and shall procure that the other Borrowers shall
          use the Facilities only for the relevant Specified Purposes.

22.1.2    NOTIFICATION OF DEFAULTS ETC


          The Parent undertakes to notify the Lender of:

          (a)       any Default or Event of Default immediately upon becoming
                    aware of its occurrence;

          (b)       any litigation, arbitration or administrative proceedings or
                    claims in which any Material Company is concerned or to
                    which it is a party involving a sum in excess of L100,000
                    immediately upon becoming aware that it is so concerned or
                    on becoming a party;

          (c)       any Security (other than a Permitted Security Interest)
                    attaching to any of the assets of any Material Company; and

          (d)       any company becoming or ceasing to be a Material Company.

22.1.3    The Parent undertakes to the Agent and the other Finance Parties that
          it shall, and it shall procure that each Material Company shall, save
          with the prior written consent of the Agent during the Security
          Period:-

          (a)       INSURANCES: effect and maintain such insurance over its
                    assets and business in such manner and to such extent as is
                    reasonable and customary

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                    for a business engaged in the same or a similar activity and
                    the same or similar localities to it (subject always to the
                    terms of any Security Document) and shall maintain such
                    policies of insurance in full force and effect and comply
                    with all its obligations relating thereto;

          (b)       BANKING: maintain and continue to maintain its current
                    accounts, exchange, interest hedging and electronic and
                    transmission banking business with the Working Capital Bank
                    or (in the case of Material Companies incorporated in the
                    United States of America only) the Approved Financier;

          (c)       PAYMENTS RECEIVED: ensure that all moneys which it may
                    receive in respect of its book debts and other debts are
                    paid into its account with the Working Capital Bank and that
                    all of its transmission banking business is carried out by
                    the Working Capital Bank or the Approved Financier;

          (d)       TAX: pay and discharge all Taxes and governmental charges
                    payable by or assessed upon it prior to the date on which
                    the same become overdue or before any material penalty is
                    incurred, unless and to the extent that such Taxes shall be
                    contested in good faith by appropriate proceedings, pending
                    determination of which payment may be lawfully withheld, and
                    there shall be set aside adequate reserves with respect to
                    such Taxes or charges so contested in accordance with GAAP;

          (e)       SECURITY: procure that subject to compliance with applicable
                    laws, each Material Company not being a member of the
                    Clinical Group shall grant Full Group Security and in such
                    form as the Security Trustee for the Agents and the Lenders,
                    the Working Capital Banks and the Working Capital Bank may
                    reasonably specify and shall take all such steps, sign all
                    such documents in relation to such security and give all
                    such assurances as may be necessary to protect such security
                    and ensure compliance with its obligations thereunder
                    (provided that nothing in this Clause 22.1.3(e) shall
                    require any Material Company to grant any Security any
                    earlier than is expressly contemplated by other provisions
                    of this Agreement);

          (f)       LICENCES: at all times have and keep in force all licences,
                    consents, permits and authorisations required:

                    (i)       for the conduct of its business, trade and
                              ordinary activities generally where failure to
                              comply or failure to obtain and maintain, as the
                              case may be, is reasonably likely to have a
                              Material Adverse Effect; and

                    (ii)      to enable it to perform its obligations under the
                              Finance Documents; and

                    (iii)     will upon request provide to the Agent a copy of
                              such licences, consents, permits and
                              authorisations, and will operate its business in
                              accordance with all applicable rules, regulations
                              and codes of good practice;

          (g)       INTRA GROUP TRANSACTIONS: ensure all transactions between it
                    and other members of the Group, whether or not otherwise
                    permitted hereunder, shall be on arm's length commercial
                    terms;


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        (h)     ENVIRONMENTAL COMPLIANCE: do all things necessary lawfully to
                comply with and to ensure compliance by all of its and their
                officers, employees and other persons with all Environmental
                Laws and Environmental Licences and promptly on:


               (i)    receipt of any communication alleging a breach of
                      Environmental Laws and/or Environmental Licences; and/or


               (ii)   becoming aware of any such breach or any claim relating to
                      Environmental Laws and/or Environmental Licences or to any
                      such breach;


               notify the Agent of that event and of the steps it is taking (and
               hereby agrees to take) to prevent, remove or mitigate that event;


        (i)    ENVIRONMENTAL INDEMNITY: indemnify the Finance Parties, any
               receiver appointed by the Security Trustee and their respective
               officers, employees and agents against all costs and reasonable
               expenses suffered or incurred by them (save in the case of such
               party's own gross negligence or wilful default) which arise as a
               result of :


               (i)    any actual or threatened breach of Environmental Law by
                      it;


               (ii)   any actual or threatened release or exposure to a
                      Dangerous Substance on, at or from the premises or
                      operations of any member of the Group; or


               (iii)  any actual or threatened claim referred to in (h) above;


        (j)     ENVIRONMENTAL PROTECTION ACT: where environmental harm in terms
                of the Environmental Protection Act 1990 (as amended by the
                Environment Act 1995) has been caused to any property belonging
                to any member of the Group over which the Security Agent has or
                will have a security interest pursuant to a Security Document,
                ensure that none of the Group is the "appropriate person" in
                terms of that Act who has caused or knowingly permitted that
                harm to occur and be aware both of the identity of the
                appropriate person and of that person's current financial
                condition;


        (k)     MAINTAIN INTELLECTUAL PROPERTY: preserve its Intellectual
                Property Rights and observe all covenants and stipulations
                affecting them where any failure to do so could have a Material
                Adverse Effect;


        (l)    KEYMAN INSURANCE: ensure that as soon as reasonably practicable
               and in any event by the date falling three months after Closing
               each Keyman Insurance is effective; and that thereafter each
               Keyman Insurance is maintained and nothing is done or omitted
               which would result in any such policy lapsing or not being
               renewed;


        (m)    DORMANT COMPANIES: procure that none of the companies listed in
               Part 2 of Schedule 16 ceases to be a Dormant Company, other than
               as a result of a liquidation of any such company which would not
               be an Event of Default, and do not acquire any assets which would
               make them a Material Company and do not assume any liabilities;


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        (n)    ACCESS: on receipt of reasonable notice from the Agent permit the
               Agent and any person authorised by the Agent to have at all
               reasonable times during normal business hours access to its
               premises and account books and records to make extracts from and
               take copies of its accounting records and to discuss any matter
               with its management;


        (o)    MERGER DOCUMENTS: take all reasonable and practical steps to
               preserve and enforce its rights under any Merger Document unless
               it is agreed between the Parent and the Agent that it is not
               commercially prudent to do so;


        (p)    RE-DENOMINATION HEDGING: use all reasonable endeavours to enter
               into, within 7 Business Days of today's date, such arrangements
               designed to hedge against exchange rate exposure on
               re-denomination of Parent Series 1 Acquisition Term Facility,
               Canada Holdco Series 1 Acquisition Term Facility, Parent Series 2
               Acquisition Term Facility and Canada Holdco Series 2 Acquisition
               Term Facility as the Agent may reasonably request, and in any
               event enter into such arrangements within 14 Business Days of
               today's date;


        (q)    HEDGING: within one month of Closing enter into such arrangements
               as the Agent may reasonably require in order to hedge against the
               Group's exposure to fluctuation of interest rates (in respect of
               not less than 66% of the aggregate maximum principal amount of
               the Series 1 Term Facilities, the Series 2 Term Facilities and
               the Capital Expenditure Facility) and thereafter from time to
               time enter into such other or amended arrangements as the Agent
               may reasonably require for the same purposes;


        (r)    COMPLIANCE WITH LAWS: comply in all respects with all laws to
               which it may be subject, if failure to do so would have a
               Material Adverse Effect;


        (s)    INFORMATION: Promptly inform the Agent of any matter which may
               constitute a breach of any of the representations, warranties or
               conditions contained in the Merger Agreement and the exercise of
               any statutory appraisal rights with regard to the Tender Offer;


        (t)    ERISA:


               (i)    comply with all applicable provisions of ERISA and the
                      regulations and published interpretations thereunder with
                      respect to all Employee Benefit Plans;


               (ii)   not take any action or fail to take action the result of
                      which could be a liability to the PBGC or to a
                      Multiemployer Plan;


               (iii)  not participate in any prohibited transaction that could
                      result in any civil penalty under ERISA or tax under the
                      Code;


               (iv)   operate each Employee Benefit Plan in such a manner that
                      will not incur any tax liability under Section 4980B of
                      the Code or any liability to any qualified beneficiary as
                      defined in Section 4980B of the Code; and


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               (v)    furnish to the Administrative Agent upon the
                      Administrative Agent's request such additional information
                      about any Employee Benefit Plan as may be reasonably
                      requested by the Administrative Agent.


22.1.4  The Parent undertakes to the Agent and the other Finance Parties that it
        shall procure the prompt (and in any event within seven Business Days of
        execution of the Merger Agreement) launch of the Tender Offer; the
        prompt commencement of the long form or short form (as appropriate)
        merger of US Newco and Target Company; and that all steps (including
        voting any Tender Offer Stock) will be taken with a view to obtaining
        stockholder approval of the Merger as soon as is reasonably practicable
        in all the circumstances.


22.1.5  The Parent shall use all reasonable endeavours to procure that on the
        day on which any Loan is made for the purpose specified in Clause
        3.1.2(b) the Agent shall have received the duly executed Second Stage
        Security; declaring that if the Parent has not delivered duly executed
        Second Stage Security pursuant to this Clause 22.1.5 by that date
        falling 90 days after Closing the Margin in respect of each Facility
        shall upon that date increase by seventy five basis points per annum
        (0.75%).


22.1.6  The Parent undertakes to the Agent and the other Finance Parties that it
        shall procure the completion of the Intra Group Transfer within 90 days
        of Closing.


22.1.7  The Parent undertakes to the Security Trustee and the other Finance
        Parties that it shall procure the execution and delivery to the Security
        Trustee as soon as reasonably practicable after completion of the Intra
        Group Transfer of the Third Stage Security.


22.1.8  The Parent undertakes to procure that within 90 days of Closing all
        required exemptions will be obtained from the Quebec Securities
        Commission in relation to the securities issued pursuant to Target's
        employee stock option plan to employees of Target or any Subsidiary
        resident in the province of Quebec (but for the avoidance of doubt
        excluding any additional exemptions as to re-sale of such securities
        other than following statutory hold periods and the like).


22.1.9  The Parent undertakes to procure the refinancing of the Target Group US
        Lender Indebtedness and the delivery to the Agent of:


        (a)    evidence that all Securities, guarantees and indemnities granted
               by any Target Group Company (subject to any Permitted Security
               Interests) have been discharged and that no Group Companies have
               granted any Securities, guarantees or indemnities other than
               Permitted Security Interests;


        (b)    US Pay-off Letter (in re Target Group US Lender Indebtedness);
               and


        (c)    UCC - 3 termination statements (in re Target Group US Lender
               Indebtedness),


        within 2 Business Days of the initial Utilisation of the Facilities.


22.1.10 The Parent undertakes to use all reasonable endeavours to procure
        release of the Letter of Credit issued by The Royal Bank of Canada in
        connection with the current


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        litigation between Clintrials BioResearches Limited and Technilab Inc
        (whether by use of a Utilisation under the Working Capital Facility or
        otherwise).


22.2    NEGATIVE UNDERTAKINGS


22.2.1  The Parent undertakes it shall not, and it shall procure that, save with
        the prior written consent of the Agent, none of the Material Companies
        will:-


        (a)    NEGATIVE PLEDGE: create or permit to subsist (with the exception
               of any Permitted Security) any Security on the whole or any part
               of its present or future assets, property or revenue;


        (b)    FINANCIAL INDEBTEDNESS: incur or permit to subsist any Financial
               Indebtedness other than Permitted Financial Indebtedness;


        (c)    LOANS: make any loans or grant any credit to or for the benefit
               of any person other than:


               (i)    amounts of credit allowed by the relevant Material Company
                      in the normal course of its trading activities; or


               (ii)   loans made by one Obligor to another Obligor; or


               (iii)  loans made by a Group Company which is not an Obligor to
                      another such Group Company; or


               (iv)   loans made by a Group Company to its employees where such
                      loans do not, when aggregated with all such loans made by
                      all Group Companies, exceed L100,000 at any time; or


               (v)    any loan which constitutes Permitted Financial
                      Indebtedness; or


               (vi)   any loan falling within the terms of Clause 22.3.5;


               (vii)  loans not included in paragraphs (i) to (vi) above which
                      when aggregated with all such loans do not exceed
                      L100,000;


        (d)    CAPITAL EXPENDITURE: incur any Capital Expenditure in any
               Financial Year of the Parent in excess of that provided for in
               the Business Plan for that Financial Year or in excess of that
               provided for in the Operating Budget agreed pursuant to Clause
               20.1(c) provided that nothing in this Clause 22.1.2(d) shall
               prevent any amount of Capital Expenditure contemplated in a
               previous year's Operating Budget which was not in fact incurred
               in that year being permissable Capital Expenditure in the
               succeeding year;


        (e)    CHANGE OF BUSINESS: make or threaten to make any material change
               in the nature or scope of its business as presently conducted
               except as specified in the Business Plan;


        (f)    DISPOSALS: (whether by a single transaction or a member of
               related or unrelated transactions and whether at the same time or
               over a period of time) sell, transfer, lease or otherwise dispose
               of or cease to exercise direct control over all or any part of
               its undertaking, assets or revenues or any interest thereon or
               the right to receive or be paid the same or agree or


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               attempt to do so, save that this restriction shall not apply to
               any Permitted Disposal;


        (g)    ACQUISITIONS: acquire or make any investment in any companies
               (other than in relation to the purchase of the Target Stock),
               joint ventures or partnerships or acquire any businesses (or
               interests therein) provided that any Group Company may:


               (i)    make two acquisitions of all (but not less than all) of
                      any company or business:


                      1)     whose business is clinical trial operations;


                      2)     which showed profits on its ordinary activities at
                             the date of its most recent audited financial
                             statements or its most recent financial statements
                             provided in the latter case that the Parent obtains
                             confirmation of the accuracy of such financial
                             statements from an internationally recognised firm
                             of accountants in their due diligence report
                             relating to the relevant acquisition;


                      3)     for which the total price paid if an acqusition by
                             a Ringfenced Group Member, when aggregated with any
                             previous acquisition by any Ringfenced Group
                             Member, does not exceed US$2,000,000 and if an
                             acquisition by a Clinical Group Member, when
                             aggregated with any previous acquisition by any
                             Clinical Group Member, does not exceed
                             USL5,000,000;


               (ii)   invest in any new joint venture or partnership provided
                      that the total investments pursuant to this Clause
                      22.2.1(g)(ii) during any financial year do not exceed a
                      maximum aggregate amount of L250,000 and the total
                      investments pursuant to this Clause 22.2.1(g)(ii) during
                      the Finance Period do not exceed a maximum aggregate
                      amount of L1,000,000; and


               (all of the above figures being inclusive of the costs and
               expenses incurred in making such acquisitions or investments)
               provided that no new Subsidiary may be acquired or incorporated
               for the purposes of improving the tax structure of the Group if
               such acquisition or incorporation would impair the security
               position of the Finance Parties and provided further that in the
               event that any Group Company purchases shares in a company which
               thereby becomes a Subsidiary, it shall procure that such
               Subsidiary promptly on being required (subject to the compliance
               with applicable laws) gives Full Group Security to the Security
               Trustee;


        (h)    CONSTITUTIONAL DOCUMENTS: amend or consent to the amendment of
               any provision of its memorandum or articles of association or
               equivalent constitutional documents in any way which is adverse
               to the interests of any Finance Party under the Finance
               Documents;


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        (i)    MERGER: merge or consolidate with any other person other than an
               Obligor or pursuant to the Merger (unless pursuant to a
               reconstruction or amalgamation previously approved in writing by
               the Agent);


        (j)    SHARE ISSUES ETC: other than pursuant to a rights issue or in
               accordance with the Equity Documents issue any shares or
               otherwise amend its authorised or issued share capital or convene
               any meeting of any member of the Group for any such purpose;


        (k)    REDEMPTIONS: redeem, purchase or otherwise acquire for
               consideration any shares or warrants issued by it or set apart
               any sum for any such purpose or otherwise reduce its capital;


        (l)    FEES: other than as required or permitted under the Transaction
               Documents, pay any fees or commissions to any persons other than
               any fees payable by an Obligor on arm's length terms to third
               parties who have rendered service or advice to that Obligor
               required by that Obligor in the ordinary course of its business;


        (m)    DEALINGS WITH AFFILIATES:  enter into:


               (i)    any arrangement or contract with any of its Affiliates
                      unless such arrangement or contract is entered into on an
                      arm's length basis and is fair and equitable to such
                      member of the Group; or


               (ii)   any other transaction, arrangement or contract with any of
                      its Affiliates which would not be entered into by a
                      prudent person in the position of the member of the Group
                      concerned or which is on terms which are less favourable
                      to that member of the Group than those obtainable from any
                      person who is not one of such members' Affiliates;


        (n)    ACCOUNTING POLICIES: it will not adopt any accounting policy or
               change the consistency of application of its accounting
               principles from the Appropriate Accounting Principles unless:


                (i)   the revised policy and practice adopted from time to
                      time is in accordance with GAAP; and


               (ii)   provided that prior to any revised policy and practice
                      being adopted the Parent will notify the Agent thereof
                      and, if required by the Agent, will negotiate in good
                      faith with the Agent in order that the financial covenants
                      set out in Clause 21 may be amended as required by the
                      Agent in order for the Finance Parties to be able to make
                      the same judgements as to the financial performance of the
                      Group as they are able to under the present accounting
                      policy provided that if such negotiations are not
                      concluded to the satisfaction of the Agent within a period
                      of 30 days from the commencement of such negotiations the
                      Parent agrees that it will provide either financial
                      statements on the same basis as before or provide
                      financial statements containing a statement reconciling
                      the previous and the then current accounting policy in
                      order that the Finance Parties may


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                      determine the financial condition of the Group having
                      regard to the terms of this Agreement;


        (o)    ACCOUNTING REFERENCE DATE: change its accounting reference date
               (or permit any of its Subsidiaries to do so) from 31 December or
               change its Auditors except to another firm of international
               repute and provided that such new Auditors have satisfied the
               Agent that they would be able to and would provide the
               information and documentation required of the Auditors under this
               Agreement;


        (p)    TAX RESIDENCE:  change its place of residence for tax purposes;


         (q)   SHAREHOLDER PAYMENTS: save to the extent permitted by the
               Interecreditor Deed, declare or pay, directly or indirectly, any
               Shareholder Payment other than in favour of an other Obligor
               which is a wholly owned Subsidiary of the Parent;


         (r)   BANK ACCOUNTS: open or maintain any account for banking purposes
               other than with the Working Capital Bank or any account with the
               Approved Financier;


         (s)   AMENDMENTS TO DOCUMENTS: amend or waive any provisions of the
               Merger Documents or the Equity Documents which have, or would be
               likely to have, an adverse effect on the interests of any Finance
               Party under the Finance Documents;


         (t)   OFF BALANCE SHEET FINANCE: enter into any off balance sheet
               financing;


         (u)   HEDGING: enter into any arrangements for the hedging of its
               exposure to floating interest rates other than in terms of the
               Hedging Agreements;


        (v)    PAYMENT OF INDEBTEDNESS:  repay, prepay or otherwise satisfy any
               indebtedness owed by it to any member of the Group other than an
               Obligor;


22.3    RINGFENCED UNDERTAKINGS


        The Parent undertakes to procure that (without prejudice to the terms of
        Clause 22.1.3(g)) save with the prior written consent of the Agent;


22.3.1  no asset title to which is held by a Ringfenced Group Member shall be
        sold or transferred to a Clinical Group Member other than for full value
        payable immediately and otherwise on arm's length commercial terms;


22.3.2  no liability of any Clinical Group Member shall pass or be transferred
        (howsoever) to any Ringfenced Group Member;


22.3.3  no Clinical Group Member (or any part of its business or undertaking)
        will be merged or integrated with any Ringfenced Group Member (or any
        part of its business or undertaking);


22.3.4  no Ringfenced Group Member will guarantee, assume (voluntarily or
        involuntarily) or grant any Security in respect of any liability (actual
        or contingent) of any Clinical Group Member;


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22.3.5  no cash shall be transferred from or by any Ringfenced Group Member to
        any Clinical Group Member save for the amount of cash held in the
        Ringfenced Group at Drawdown Date up to a maximum amount of
        US$12,000,000;


22.3.6  no Clinical Group Member shall incur any Financial Indebtedness to any
        Ringfenced Group Member.


22.4    MERGER - RELATED UNDERTAKINGS


22.4.1  The Parent undertakes that it shall not and it shall procure that, save
        with the prior written consent of the Agent, US Newco will not:


        (a)    AMENDMENTS: amend or seek to amend any of the terms or conditions
               of the Tender Offer or the Merger Agreement (other than for the
               purposes of corrections of typographical or other immaterial
               errors) provided that the Parent shall retain the right to amend,
               without the consent of the Agent, the terms and conditions of the
               Tender Offer and the Merger Agreement as required by the US
               Securities and Exchange Commission or any governmental or
               regulatory authority or to comply with any applicable laws;


        (b)    WAIVERS: waive or seek to waive any conditions of the Tender
               Offer set out in Annex A to the Merger Agreement or the Merger
               Agreement;


        (c)    TERMINATE: terminate or seek to terminate the Merger Agreement
               after the Drawdown Date.


22.4.2  The Parent undertakes that:


        (a)    ANNOUNCEMENTS: all publicity material, press releases and
               announcements intended to be published in relation to the Tender
               Offer and/or Merger shall as soon as practicable prior to
               publication be furnished to the Agent, and where such material
               refers to the Agent or any party hereto other than a Group
               Company shall require to be approved by such party prior to such
               publication (such approval not to be unreasonably withheld or
               delayed);


        (b)    PROGRESS OF OFFER: the Parent will provide the Agent with all
               information in respect of progress of the Tender Offer and Merger
               which is material to the interests of the Finance Parties and
               will provide the Agent with any information and copies of
               professional advice received as the Agent may reasonably request;


        (c)    DISCLOSURE: the Parent will make full disclosure to the Agent in
               writing as soon as practicable of all information which comes to
               the attention of the Parent and which is material to the decision
               whether to waive any condition of the Tender Offer or which
               suggests that any condition of the Tender Offer will or may not
               be satisfied, or will or may require to be waived;


        (d)    PRICE: it will not do anything that will result in the US
               Securities and Exchange Commission requiring an increase in the
               Common Stock Price.


23      EVENTS OF DEFAULT


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        Each of the events or circumstances set out in Clause 23 is an Event of
        Default, save that no event or circumstance relative to the Target Group
        which would otherwise constitute an Event of Default will do so prior to
        the Clean Up Date (provided that steps which are designed to remedy the
        relevant event or circumstance and which are satisfactory to the Agent
        (acting reasonably) are being taken) unless the relevant event or
        circumstance in the reasonable opinion of the Lenders could have a
        Material Adverse Effect.


23.1    NON-PAYMENT


        An Obligor fails to pay any amount of principal or interest payable by
        it under a Finance Document at the place and in the currency and funds
        in which it is expected to be payable on demand, if so payable, or on
        its due date or if such non-payment is caused by any technical
        malfunction in the banking system (as the same may be determined by the
        Agent or Lenders) within 3 Business Days after such demand or due date
        or fails to pay any other such amount within 3 Business Days of its due
        date; or


23.2    CERTAIN OBLIGATIONS


        If an Obligor fails to comply with any of the provisions of Clauses 21,
        22.1.3(p), 22.2.1(a), (b), (c), (d), (k), (q), (s), (u), 22.3, or 22.4
        of this agreement; or


23.3    OTHER OBLIGATIONS


        An Obligor fails to comply with any of the covenants or undertakings
        under any Finance Document (other than the obligations referred to in
        Clauses 23.1 and 23.2) and, if that breach is capable of remedy it is
        not remedied within ten Business Days after notice of that breach has
        been given by the Agent to the Parent; or


23.4    MISREPRESENTATION


        Any representation or warranty or statement by any Obligor in any
        Finance Document or in any notice or other document, certificate or
        statement delivered pursuant thereto or in connection therewith or
        repeated at any time in accordance with the terms thereof is or proves
        to have been incorrect in any material respect when made or when deemed
        to be repeated; or


23.5    CROSS DEFAULT


        Any Material Company defaults in the performance of any other agreement
        in respect of or relating to Financial Indebtedness in excess of, in
        aggregate L100,000, so as to accelerate or render capable of
        acceleration the due date of payment or repayment thereunder or any such
        Financial Indebtedness is not repaid or paid in full on the due date or
        repayment of any such Financial Indebtedness is due on demand and is not
        paid in full forthwith on such demand being made or any undrawn
        facilities are withdrawn by any creditor by reason of default or
        financial difficulties on the part of such Material Company; or


23.6    INABILITY TO PAY DEBTS


        Any Material Company is unable or admits its inability to pay its debts
        or otherwise suspends making payments to all or any class of its
        respective creditors or announces an intention to do so or begins
        negotiations with any creditor with a view


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        to the general readjustment or rescheduling of all or any class of its
        Financial Indebtedness or proposes or enters into any composition or
        other arrangement for the benefits of its creditors generally or any
        class of creditors; or


23.7    LEGAL PROCESS


        Any distress, execution, arrestment, attachment, inhibition or other
        diligence or legal process affects any asset of any Material Company in
        respect of a liability in excess of L100,000 (or its equivalent), other
        than any such distress, execution, arrestment, attachment, inhibition or
        other diligence or legal process which is contested in good faith and is
        fully discharged within 14 Business Days; or


23.8    INSOLVENCY PROCEEDINGS


        Any person takes any action or any legal proceedings are started or
        other steps taken (including the presentation of a petition) for:


        (a)    any Material Company to be adjudicated or found insolvent;


        (b)    the winding up or dissolution of any Material Company other than:


               (i)    for the purpose of a solvent reconstruction or
                      amalgamation the terms of which have previously been
                      approved by the Agent in writing; or


               (ii)   a winding up petition which is proved to the satisfaction
                      of the Agent acting reasonably to be frivolous or
                      vexatious and which is discharged within 21 days of its
                      presentation and before it is advertised; or


        (c)    the appointment of a trustee, receiver, administrative receiver
               or similar office in respect of any Material Company or any of
               its assets; or


23.9    INSOLVENCY ORDER


        Any adjudicative, order or appointment is made under or in relation to
        any of the proceedings referred to in Clause 23.8; or


23.10   ADMINISTRATION


        An application is made to the court for an administration order under
        the Insolvency Act 1986 against any member of the Group; or


23.11   REPOSSESSION OF GOODS


        Any other creditor(s) repossess any goods in the possession of any
        member of the Group under any hire purchase, conditional sale, leasing,
        retention of title or similar agreement and such steps have a Material
        Adverse Effect on the business assets or financial condition of any
        Material Company; or


23.12   ANALOGOUS PROCEEDINGS


        Any condition, event or action is taken, occurs or exists under the laws
        of any other country or political subdivision thereof, to the
        jurisdiction of which any member of the Group or its respective assets
        or revenues is subject, which has a substantially


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        equivalent effect to any of the conditions, events or acts mentioned in
        Clause 23.6 to 23.11 (inclusive); or


23.13   CHANGE OF CONTROL


        After the date of this Agreement, control (as defined in Clause 8.2.2)
        of the Parent passes without the consent of the Agent to any person, or
        persons acting either individually or in concert (other than the
        shareholders of the Parent as at the date of this Agreement)
        (disregarding for the purposes of this Clause 23.13 any sale by the
        Investors of up to 50% of the issued share capital of Parent in the
        context of any syndication by it); or


23.14   MANAGEMENT TEAM


        Save with the consent of the Finance Parties, any of the Management Team
        or a person who has replaced him under the provisions of this Clause
        23.14 ceases to be an employee (which shall be deemed to be the case if
        he dies or becomes permanently incapacitated or is unable to perform his
        executive functions for any other reason other than holiday or sickness
        not exceeding 60 days in any period of 120 days) and a replacement
        reasonably acceptable to the Finance Parties has not commenced
        employment with the Parent within 180 days of the date on which the
        relevant cessation occurred (which in the event of a deemed cessation
        through holiday or sickness shall occur on the 61st day); or


23.15   LITIGATION


        Any Material Company becomes subject to any litigation, arbitration or
        administrative, proceeding which in the reasonable opinion of the Agent
        is likely to be adversely determined and, if adversely determined, would
        have a Material Adverse Effect; or


23.16   SUBSIDIARIES


        Any Obligor (other than the Parent) ceases to be a wholly owned
        Subsidiary of the Parent on or after the first drawdown date save as
        permitted by this Agreement or with the prior written consent of the
        Agent;


23.17   INVALIDITY


        Any provision of this Agreement or the Security Documents which the
        Agent (acting reasonably) considers material is, or becomes for any
        reason, invalid or unenforceable; or


23.18   CHANGE IN NATURE OF BUSINESS


        Any Obligor changes the nature of its business, suspends, ceases or
        threatens to suspend or cease to carry on all or a substantial part of
        the present business and operations which it now conducts directly or
        indirectly, or any governmental authority expropriates or threatens to
        expropriate or nationalise all or a significant part of its assets and
        the result of any of the foregoing will, in the opinion of the Finance
        Parties have a Material Adverse Effect; or


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23.19   LICENCES


        Any authorisation, approval, consent, licence, exemption, filing,
        registration or notarisation or other requirement necessary to enable
        any Obligor to perform its material obligations under any Finance
        Document to which it is a party is modified, revoked or withheld or does
        not remain in full force and effect and the same has a Material Adverse
        Effect; or


23.20   QUALIFIED ACCOUNTS


        The Parent's Auditors qualify their report to any audited financial
        statements of the Group in any way which is (in the opinion of the
        Agent) material in the context of the Facilities; or


23.21   INTER CREDITOR DEED


        Any party to the Inter Creditor Agreement (other than any Finance Party)
        fail to comply with its obligations under the Inter Creditor Agreement
        or the Inter Creditor Agreement ceases to be binding upon any such party
        for whatever reason and, as a result the position of the Finance Parties
        under the Finance Documents is materially prejudiced;


23.22   ERISA TERMINATION EVENT


        The occurrence of any of the following events if it has or in the
        reasonable opinion of the Agent is likely to have a Material Adverse
        Effect:


23.22.1 any Borrower, any Group Company or any ERISA Affiliate fails to make
        full payment when due of all amounts which, under the provisions of any
        Pension Plan or Section 412 of the Code, such Borrower, Subsidiary or
        ERISA Affiliate is required to pay as contributions thereto;


23.22.2 an accumulated funding deficiency in excess of $100,000 occurs or
        exists, whether or not waived, with respect to any Pension Plan;


23.22.3 a Termination Event; or


23.22.4 any Borrower, any Group Company or any ERISA Affiliate as employers
        under one or more Multiemployer Plan makes a complete or partial
        withdrawal from any such Multiemployer Plan and the plan sponsor of such
        Multiemployer Plans notifies such withdrawing employer that such
        employer has incurred a withdrawal liability requiring payments in an
        amount exceeding $100,000.


23.23   MATERIAL ADVERSE EFFECT


        Any adverse change in the business, prospects of financial condition of
        an Obligor occurs which, in the reasonable opinion of the Lenders could
        have a Material Adverse Effect.


23.24   ACCELERATION


        On and at any time after the occurrence of an Event of Default which is
        continuing the Agent may, and shall if so directed by the Majority
        Lenders, by notice to the Parent:


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        (a)    cancel the Total Commitments whereupon they shall immediately be
               cancelled;


        (b)    declare that all or part of the Loans, together with accrued
               interest, and all other amounts accrued under the Finance
               Documents be immediately due and payable, whereupon they shall
               become immediately due and payable;


        (c)    declare that all or part of the Loans be payable on demand,
               whereupon they shall immediately become payable on demand by the
               Agent on the instructions of the Majority Lenders; and/or


        (d)    declare that all or part of the Working Capital Facility (insofar
               as not already payable on demand) be repayable on demand
               whereupon it shall become immediately due and payable.


23.25   LIMITATION DURING AVAILABILITY PERIOD


        Prior to the end of the Availability Period, and subject to compliance
        by the relevant Group Companies with Clauses 3.3 and 3.4 unless a
        Primary Default has occurred (in the period prior to the Drawdown Date)
        no Finance Party shall:


        (a)    be entitled to exercise any right of rescission or other remedy
               (whether under the Finance Documents or the general law) or
               exercise any remedy under Clause 23.24; or


        (b)    refuse to make available any Parent Series 1 Acquisition Term
               Facility Loan, Parent Series 2 Acquisition Term Facility Loan,
               Canada Holdco Series 1 Acquisition Term Facility Loan or Canada
               Holdco Series 2 Acquisition Term Facility Loan.


24      CHANGES TO THE LENDERS


24.1    ASSIGNMENT AND TRANSFERS BY THE LENDERS


        A Lender, or any successor or assignee of such Lender, (in this capacity
        the "EXISTING LENDER") may at any time assign, novate or otherwise
        transfer all or any part of its rights or obligations under the Finance
        Documents (or any of them) to any Qualifying Lender (a "NEW LENDER").


24.2    OBLIGATIONS


        A transfer of obligations will only be effective if made in accordance
        with Clause 24.6 or if the New Lender has, prior to the transfer taking
        effect, confirmed in writing to the Agent (acting on behalf of all the
        other Lenders) and to the Parent that it undertakes to be bound by the
        terms of each of the Finance Documents as a Lender in form and substance
        satisfactory to the Agent and the Parent, in the case of the Parent not
        to be unreasonably withheld or delayed. On any such transfer being made,
        the Existing Lender will be relieved of its obligations to the extent
        that they are transferred to the Transferee.


24.3    PARENT UNDERTAKING


        The Parent will execute such documents and agreements as are necessary
        to effect a transfer of rights or obligations to a New Lender hereunder.


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24.4    LENDERS ABILITY TO SUB-CONTRACT


        Nothing in this Agreement will restrict the ability of a Lender to
        sub-contract any or all of its obligations under the Finance Documents
        (or any of them) if such Lender remains liable under this Agreement in
        relation to those obligations.


24.5    LIMITATION OF RESPONSIBILITY OF EXISTING LENDERS


24.5.1  Unless expressly agreed to the contrary, an Existing Lender makes no
        representation or warranty and assumes no responsibility to a New Lender
        for:


        (a)    the legality, validity, effectiveness, adequacy or enforceability
               of the Finance Documents or any other documents;


        (b)    the financial condition of any Obligor;


        (c)    the performance and observance by any Obligor of its obligations
               under the Finance Documents or any other documents; or


        (d)    the accuracy of any statements (whether written or oral) made in
               or in connection with any Finance Document or any other document,


        and any representations or warranties implied by law are excluded.


24.5.2  Each New Lender confirms to the Existing Lender and the other Finance
        Parties that it:


        (a)    has made (and shall continue to make) its own independent
               investigation and assessment of the financial condition and
               affairs of each Obligor and its related entities in connection
               with its participation in this Agreement and has not relied
               exclusively on any information provided to it by the Existing
               Lender in connection with any Finance Document; and


        (b)    will continue to make its own independent appraisal of the
               creditworthiness of each Obligor and its related entities whilst
               any amount is or may be outstanding under the Finance Documents
               or any Commitment is in force.


24.5.3  Nothing in any Finance Document obliges an Existing Lender to:


        (a)    accept a re-transfer from a New Lender of any of the rights and
               obligations assigned or transferred under this Clause 24; or


        (b)    support any losses directly or indirectly incurred by the New
               Lender by reason of the non-performance by any Obligor of its
               obligations under the Finance Documents or otherwise.


24.6    PROCEDURE FOR TRANSFER


24.6.1  Subject to the conditions set out in Clause 24.2 a transfer is effected
        in accordance with Clause 24.6.2 when the Agent executes an otherwise
        duly completed Transfer Certificate delivered to it by the Existing
        Lender and the New Lender. The Agent shall, as soon as reasonably
        practicable after receipt by it of a duly completed Transfer Certificate
        appearing on its face to comply with the terms of this


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        Agreement and delivered in accordance with the terms of this Agreement,
        execute that Transfer Certificate.


24.6.2  On the Transfer Date:


        (a)    to the extent that in the Transfer Certificate the Existing
               Lender seeks to transfer by novation its rights and obligations
               under the Finance Documents each of the Obligors and the Existing
               Lender shall be released from further obligations towards one
               another under the Finance Documents and their respective rights
               against one another shall be cancelled (being the "DISCHARGED
               RIGHTS AND OBLIGATIONS");


        (b)    each of the Obligors and the New Lender shall assume obligations
               towards one another and/or acquire rights against one another
               which differ from the Discharged Rights and Obligations only
               insofar as that Obligor and the New Lender have assumed and/or
               acquired the same in place of that Obligor and the Existing
               Lender;


        (c)    the Agent, the Arranger, the New Lender and other Lenders shall
               acquire the same rights and assume the same obligations between
               themselves as they would have acquired and assumed had the New
               Lender been an Original Lender with the rights and/or obligations
               acquired or assumed by it as a result of the transfer and to that
               extent the Agent, the Arranger and the Existing Lender shall each
               be released from further obligations to each other under this
               Agreement; and


        (d)    the New Lender shall become a Party as a "Lender".


24.7    DISCLOSURE OF INFORMATION


        Any Lender may disclose to any of its Affiliates and any other person:


        (a)    to (or through) whom that Lender assigns or transfers (or may
               potentially assign or transfer) all or any of its rights and
               obligations under this Agreement;


        (b)    with (or through) whom that Lender enters into (or may
               potentially enter into) any sub-participation in relation to, or
               any other transaction under which payments are to be made by
               reference to, this Agreement or any Obligor; or


        (c)    to whom, and to the extent that, information is required to be
               disclosed by any applicable law or regulation,


        any information about any Obligor, the Group and the Finance Documents
        as that Lender shall consider appropriate.


25      CHANGES TO THE OBLIGORS


25.1    ASSIGNATIONS AND TRANSFER BY OBLIGORS


        No Obligor may assign any of its rights or transfer any of its rights or
        obligations under the Finance Documents.


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25.2    ADDITIONAL BORROWERS


25.2.1  The Parent may request that any of its wholly owned Subsidiaries becomes
        an Additional Borrower. That Subsidiary shall become an Additional
        Borrower if:


        (a)    the Agent approve the addition of that Subsidiary;


        (b)    the Parent delivers to the Agent a duly completed and executed
               Accession Letter;


        (c)    the Parent confirms that no Default is continuing or would occur
               as a result of that Subsidiary becoming an Additional Borrower;
               and


        (d)    the Agent has received all the documents and other evidence
               listed in Part 2 of Schedule 3 in relation to that Additional
               Borrower, each in form and substance satisfactory to the Agent.


25.2.2  The Agent shall notify the Parent and the Lenders promptly upon being
        satisfied that it has received (in form and substance satisfactory to
        it) all the documents and other evidence listed in Part 2 of Schedule 3.


25.3    RESIGNATION OF A BORROWER


25.3.1  The Parent may request that a Borrower (other than the Parent) ceases to
        be a Borrower by delivering a Resignation Letter to the Agent.


25.3.2  The Agent shall accept a Resignation Letter and notify the Parent and
        the Lenders of its acceptance if:


        (a)    no Default is continuing or would result from the acceptance of
               the Resignation Letter (and the Parent has confirmed this is the
               case); and


        (b)    the Borrower is under no actual or contingent obligations as a
               Borrower under any Finance Documents,


        whereupon that company shall cease to be a Borrower and shall have no
        further rights or obligations under the Finance Documents.


25.4    ADDITIONAL GUARANTORS


25.4.1  The Parent may request that any of its Subsidiaries become an Additional
        Guarantor. That Subsidiary shall become an Additional Guarantor if:


        (a)    the Parent delivers a duly completed and executed Accession
               Letter to the Agent; and


        (b)    the Agent has received all the documents and other evidence
               listed in Part 2 of Schedule 3 in relation to that Additional
               Guarantor, each in form and substance satisfactory to the Agent.


25.4.2  The Agent shall notify the Parent and the Finance Parties promptly upon
        being satisfied that it has received (in form and substance satisfactory
        to it) all the documents and other evidence listed in Part 2 of Schedule
        3.


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25.5    REPETITION OF REPRESENTATIONS


        Delivery of an Accession Letter constitutes confirmation by the relevant
        Subsidiary that the Repeating Representations are true and correct in
        relation to it as at the date of delivery as if made by reference to the
        facts and circumstances then existing.


25.6    RESIGNATION OF A GUARANTOR


25.6.1  The Parent may request that a Guarantor (other than the Parent) ceases
        to be a Guarantor by delivering a Resignation Letter to the Agent.


25.6.2  The Agent shall accept a Resignation Letter and notify the Parent and
        the Finance Parties of its acceptance if:


        (a)    no Default is continuing or would result from the acceptance of
               the Resignation Letter (and the Parent has confirmed this is the
               case); and


        (b)    all the Finance Parties have consented to the Parent's request.


25.6.3  The Security Trustee shall thereafter execute and deliver a Deed of
        Release from the Guarantee to the former Guarantor.


26      SYNDICATION


26.1    OBLIGORS' UNDERTAKINGS


        The Obligors acknowledge that syndication of the Facilities will take
        place and undertake to take reasonable steps to assist and co-operate
        with the Agent in syndication by, among other things:


        (a)    co-operating with site visits by the Lenders and persons invited
               by the Agent and/or any Lender to participate in the Facilities
               (each such person, a "PROPOSED SYNDICATE LENDER");


        (b)    participating in presentations to the Proposed Syndicate Lenders
               concerning the Group Companies and their activities;


        (c)    using reasonable endeavours to obtain appropriate authorisations
               from the Auditors, other accountants, consultants and
               professional advisers to release for the benefit of the Proposed
               Syndicate Lenders any information addressed to any Finance Party;


        (d)    refraining from making any statement, announcement or publication
               or doing any act or thing which is designed to obstruct
               syndication in any way;


        (e)    providing the Proposed Syndicate Lenders with such information
               relating to the Group Companies and their activities as the
               Proposed Syndicate Lenders reasonably request;


        (f)    assisting the Agent and each Lender in the preparation and review
               of any information which the Agent and/or a Lender reasonably
               requires for the purposes of syndication;


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        (g)    passing on to the Agent any enquiries received by them from
               potential Lenders;


        (h)    agreeing to amendments to the Finance Documents of an
               administrative or technical nature or to correct typographical or
               clerical errors; and


        (i)    instructing (at its cost) such additional diligence as may be
               requested by the Agent, a Lender or a Proposed Syndicate Lender.


26.2    COSTS OF SYNDICATION


        All legal costs and expenses payable by the Agent or any other Finance
        Party in connection with any syndication will be reimbursed by the
        Parent to the Agent on demand by the Agent together with value added tax
        (if any).


27      ROLE OF THE AGENT, THE SECURITY TRUSTEE AND THE ARRANGER

27.1    APPOINTMENT OF THE AGENT


27.1.1  Each of the Arranger and the Lenders appoints the Agent to act as its
        agent under and in connection with the Finance Documents.


27.1.2  Each of the Arranger and the Lenders authorises the Agent to exercise
        the rights, powers, authorities and discretions specifically given to
        the Agent under or in connection with the Finance Documents together
        with any other incidental rights, powers, authorities and discretions.


27.2    DUTIES OF THE AGENT


27.2.1  The Agent shall promptly forward to a Party the original or a copy of
        any document which is delivered to the Agent for that Party by any other
        Party.


27.2.2  If the Agent receives notice from a Party referring to this Agreement,
        describing a Default and stating that the circumstance described is a
        Default, it shall promptly notify the other Finance Parties.


27.2.3  The Agent shall promptly notify the other Finance Parties of any Default
        arising under Clause 23.1.


27.2.4  The Agent's duties under the Finance Documents are solely mechanical and
        administrative in nature.


27.3    ROLE OF THE ARRANGER


        Except as specifically provided in the Finance Documents, the Arranger
        has no obligations of any kind to any other Party under or in connection
        with any Finance Document.


27.4    NO FIDUCIARY DUTIES


27.4.1  Nothing in this Agreement constitutes the Agent or the Arranger as a
        trustee or fiduciary of any other person.


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27.4.2  Neither the Agent nor the Arranger shall be bound to account to any
        Lender for any sum or the profit element of any sum received by it for
        its own account.


27.5    BUSINESS WITH THE GROUP


        The Agent and the Arranger may accept deposits from, lend money to and
        generally engage in any kind of banking or other business with any
        member of the Group.


27.6    RIGHTS AND DISCRETIONS OF THE AGENT


27.6.1  The Agent may rely on:


        (a)    any representation, notice or document believed by it to be
               genuine, correct and appropriately authorised; and


        (b)    any statement made by a director, authorised signatory or
               employee of any person regarding any matters which may reasonably
               be assumed to be within his knowledge or within his power to
               verify.


27.6.2  The Agent may assume (unless it has received notice to the contrary in
        its capacity as agent for the Lenders) that:


        (a)    no Default has occurred (unless it has actual knowledge of a
               Default arising under Clause 23.1);


        (b)    any right, power, authority or discretion vested in any Party or
               the Majority Lenders has not been exercised; and


        (c)    any notice or request made by the Parent (other than a
               Utilisation Request or Selection Notice) is made on behalf of and
               with the consent and knowledge of all the Obligors.


27.6.3  The Agent may engage, pay for and rely on the advice or services of any
        lawyers, accountants, surveyors or other experts.


27.6.4  The Agent may act in relation to the Finance Documents through its
        personnel and agents.


27.7    MAJORITY LENDERS' INSTRUCTIONS


27.7.1  Unless a contrary indication appears in a Finance Document, the Agent
        shall:


        (a)    act in accordance with any instructions given to it by the
               Majority Lenders (or, if so instructed by the Majority Lenders,
               refrain from acting or exercising any right, power, authority or
               discretion vested in it as Agent); and


        (b)    not be liable for any act (or omission) if it acts (or refrains
               from taking any action) in accordance with such an instruction of
               the Majority Lenders.


27.7.2  Unless a contrary indication appears in a Finance Document, any
        instructions given by the Majority Lenders will be binding on all the
        Lenders and the Arranger.


27.7.3  The Agent may refrain from acting in accordance with the instructions of
        the Majority Lenders (or, if appropriate, the Lenders) until it has
        received such security


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        as it may require for any cost, loss or liability (together with any
        associated VAT) which it may incur in complying with the instructions.


27.7.4  In the absence of instructions from the Majority Lenders, (or, if
        appropriate, the Lenders) the Agent may act (or refrain from taking
        action) as it considers to be in the best interest of the Lenders.


27.7.5  The Agent is not authorised to act on behalf of a Lender (without first
        obtaining that Lender's consent) in any legal or arbitration proceedings
        relating to any Finance Document.


27.8    RESPONSIBILITY FOR DOCUMENTATION


        Neither the Agent nor the Arranger:


        (a)    is responsible for the adequacy, accuracy and/or completeness of
               any information (whether oral or written) supplied by the Agent,
               the Arranger, an Obligor or any other person given in or in
               connection with any Finance Document; or


        (b)    is responsible for the legality, validity, effectiveness,
               adequacy or enforceability of any Finance Document or any other
               agreement, arrangement or document entered into, made or executed
               in anticipation of or in connection with any Finance Document.


27.9    EXCLUSION OF LIABILITY


27.9.1  Without limiting Clause 27.9.2, the Agent will not be liable for any
        action taken by it under or in connection with any Finance Document,
        unless directly caused by its gross negligence or wilful misconduct.


27.9.2  No Party may take any proceedings against any officer, employee or agent
        of the Agent in respect of any claim it might have against the Agent or
        in respect of any act or omission of any kind by that officer, employee
        or agent in relation to any Finance Document and any officer, employee
        or agent of the Agent may rely on this Clause.


27.9.3  The Agent will not be liable for any delay (or any related consequences)
        in crediting an account with an amount required under the Finance
        Documents to be paid by the Agent if the Agent has taken all necessary
        steps as soon as reasonably practicable to comply with the regulations
        or operating procedures of any recognised clearing or settlement system
        used by the Agent for that purpose.


27.10   LENDERS' INDEMNITY TO THE AGENT


        Each Lender shall (in proportion to its share of the Total Commitments
        or, if the Total Commitments are then zero, to its share of the Total
        Commitments immediately prior to their reduction to zero) indemnify the
        Agent, within three Business Days of demand, against any cost, loss or
        liability incurred by the Agent (otherwise than by reason of the Agent's
        gross negligence or wilful misconduct) in acting as Agent under the
        Finance Documents (unless the Agent has been reimbursed by an Obligor
        pursuant to a Finance Document).


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27.11   RESIGNATION OF THE AGENT


27.11.1 The Agent may resign and appoint one of its Affiliates acting through an
        office in the United Kingdom as successor by giving notice to the
        Lenders and the Parent.


27.11.2 Alternatively the Agent may resign by giving notice to the Lenders and
        the Parent, in which case the Majority Lenders (after consultation with
        the Parent) may appoint a successor Agent.


27.11.3 If the Majority Lenders have not appointed a successor Agent in
        accordance with Clause 27.11.2 within 30 days after notice of
        resignation was given, the Agent (after consultation with the Parent)
        may appoint a successor Agent (acting through an office in the United
        Kingdom).


27.11.4 The retiring Agent shall, at its own cost, make available to the
        successor Agent such documents and records and provide such assistance
        as the successor Agent may reasonably request for the purposes of
        performing its functions as Agent under the Finance Documents.


27.11.5 The Agent's resignation notice shall only take effect upon the
        appointment of a successor.


27.11.6 Upon the appointment of a successor, the retiring Agent shall be
        discharged from any further obligation in respect of the Finance
        Documents but shall remain entitled to the benefit of this Clause 27.
        Its successor and each of the other Parties shall have the same rights
        and obligations amongst themselves as they would have had if such
        successor had been an original Party.


27.11.7 After consultation with the Parent, the Majority Lenders may, by notice
        to the Agent, require it to resign in accordance with Clause 27.11.2. In
        this event, the Agent shall resign in accordance with Clause 27.11.2.


27.12   CONFIDENTIALITY


27.12.1 In acting as agent for the Finance Parties, the Agent shall be regarded
        as acting through its agency division which shall be treated as a
        separate entity from any other of its divisions or departments.


27.12.2 If information is received by another division or department of the
        Agent, it may be treated as confidential to that division or department
        and the Agent shall not be deemed to have notice of it.


27.12.3 Notwithstanding any other provision of any Finance Document to the
        contrary, neither the Agent nor the Arranger are obliged to disclose to
        any other person:


        (a)    any confidential information; or


        (b)    any other information if the disclosure would or might in its
               reasonable opinion constitute a breach of any law or a breach of
               a fiduciary duty.


27.13   RELATIONSHIP WITH THE FINANCE PARTIES


27.13.1 The Agent may treat each Finance Party as a Finance Party, entitled to
        payments under this Agreement and acting through its Facility Office
        unless it has received


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        not less than five Business Days prior notice from that Finance Party to
        the contrary in accordance with the terms of this Agreement.


27.13.2 Each Finance Party shall supply the Agent with any information required
        by the Agent in order to calculate the Mandatory Cost in accordance with
        Schedule 6.


27.14   CREDIT APPRAISAL BY THE FINANCE PARTIES


        Without affecting the responsibility of any Obligor for information
        supplied by it or on its behalf in connection with any Finance Document,
        each Finance Party confirms to the Agent and the Arranger that it has
        been, and will continue to be, solely responsible for making its own
        independent appraisal and investigation of all risks arising under or in
        connection with any Finance Document including but not limited to:


        (a)    the financial condition, status and nature of each member of the
               Group;


        (b)    the legality, validity, effectiveness, adequacy or enforceability
               of any Finance Document and any other agreement, arrangement or
               document entered into, made or executed in anticipation of, under
               or in connection with any Finance Document;


        (c)    whether that Finance Party has recourse, and the nature and
               extent of that recourse, against any Party or any of its
               respective assets under or in connection with any Finance
               Document, the transactions contemplated by the Finance Documents
               or any other agreement, arrangement or document entered into,
               made or executed in anticipation of, under or in connection with
               any Finance Document; and


        (d)    the adequacy, accuracy and/or completeness of the Information
               Memorandum and any other information provided by the Agent, any
               Party or by any other person under or in connection with any
               Finance Document, the transactions contemplated by the Finance
               Documents or any other agreement, arrangement or document entered
               into, made or executed in anticipation of, under or in connection
               with any Finance Document.


27.15   FINANCE PARTY'S TAX STATUS CONFIRMATION


        Each Finance Party confirms in favour of the Agent on the date of this
        Agreement or, in the case of a Lender which becomes a Party pursuant to
        a transfer or assignment, on the date on which the relevant transfer or
        assignment becomes effective that either:


        (a)    it is not resident for tax purposes in the United Kingdom and is
               beneficially entitled to its share of the Loan and associated
               interest; or


        (b)    it is a bank as defined for the purposes of section 349 of the
               Taxes Act and is beneficially entitled to its share of the Loan
               and associated interest,


        and each Finance Party shall promptly notify the Agent if there is any
        change in its position from that set out above.


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27.16   REFERENCE LENDERS


        If a Reference Lender (or, if a Reference Lender is not a Finance Party,
        the Finance Party of which it is an Affiliate) ceases to be a Finance
        Party, the Agent shall (in consultation with the Parent) appoint another
        Finance Party or an Affiliate of a Finance Party to replace that
        Reference Lender.


27.17   APPOINTMENT OF THE SECURITY TRUSTEE


27.17.1 Each Finance Party (except the Security Trustee) appoints the Security
        Trustee (which accepts such appointment) as its trustee to hold the
        Security Documents and all rights, powers and benefits, and the proceeds
        of realisation thereunder in trust for the benefit of the Finance
        Parties according to their respective entitlements under this Agreement
        and the other Finance Documents, with the right and power to exercise
        the rights, powers, authorities and discretions conferred on the
        Security Trustee under the Security Documents and the other Finance
        Documents, together with any other incidental rights, powers,
        authorities and discretions, as if it were beneficially entitled thereto
        in its own right.


27.17.2 The provisions of Clause 15.3, Clause 17 and Clauses 27.5 to 27.12
        (inclusive) and Clause 27.11 shall apply mutatis mutandis to the
        Security Trustee as if reference to the "Agent" were references also to
        the Security Trustee, except that the Security Trustee's resignation or
        removal shall not take effect until all necessary documents have been
        entered into to substitute its successor as holder of the Security
        Documents under the trust hereby constituted.


28      CONDUCT OF BUSINESS BY THE FINANCE PARTIES


        No provision of this Agreement will:


        (a)    interfere with the right of any Finance Party to arrange its
               affairs (tax or otherwise) in whatever manner it thinks fit;


        (b)    oblige any Finance Party to investigate or claim any credit,
               relief, remission or repayment available to it or the extent,
               order and manner of any claim; or


        (c)    oblige any Finance Party to disclose any information relating to
               its affairs (tax or otherwise) or any computations in respect of
               Tax.


29      SHARING AMONG THE LENDERS


29.1    PAYMENTS TO LENDERS


        If a Lender (a "RECOVERING LENDER") receives or recovers any amount from
        an Obligor other than in accordance with Clause 30 and applies that
        amount to a payment due under the Finance Documents then:


        (a)    the Recovering Lender shall, within three Business Days, notify
               details of the receipt or recovery, to the Agent;


        (b)    the Agent shall determine whether the receipt or recovery is in
               excess of the amount the Recovering Lender would have been paid
               had the receipt or recovery been received or made by the Agent
               and distributed in accordance with Clause 30, without taking
               account of any Tax which


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              would be imposed on the Agent in relation to the receipt,
              recovery or distribution; and


        (c)    the Recovering Lender shall, within three Business Days of demand
               by the Agent, pay to the Agent an amount (the "SHARING PAYMENT")
               equal to such receipt or recovery less any amount which the Agent
               determines may be retained by the Recovering Lender as its share
               of any payment to be made, in accordance with Clause 30.5.


29.2    REDISTRIBUTION OF PAYMENTS


        The Agent shall treat the Sharing Payment as if it had been paid by the
        relevant Obligor and distribute it between the Finance Parties (other
        than the Recovering Lender) in accordance with Clause 30.5.


29.3    RECOVERING LENDER'S RIGHTS


29.3.1  On a distribution by the Agent under Clause 29.2, the Recovering Lender
        will be subrogated to the rights of the Finance Parties which have
        shared in the redistribution.


29.3.2  If and to the extent that the Recovering Lender is not able to rely on
        its rights under paragraph (a) above, the relevant Obligor shall be
        liable to the Recovering Lender for a debt equal to the Sharing Payment
        which is immediately due and payable.


29.4    REVERSAL OF REDISTRIBUTION


        If any part of the Sharing Payment received or recovered by a Recovering
        Lender becomes repayable and is repaid by that Recovering Lender, then:


        (a)    each Lender which has received a share of the relevant Sharing
               Payment pursuant to Clause 29.2 shall, upon request of the Agent,
               pay to the Agent for account of that Recovering Lender an amount
               equal to its share of the Sharing Payment (together with an
               amount as is necessary to reimburse that Recovering Lender for
               its proportion of any interest on the Sharing Payment which that
               Recovering Lender is required to pay); and


        (b)    that Recovering Lender's rights of subrogation in respect of any
               reimbursement shall be cancelled and the relevant Obligor will be
               liable to the reimbursing Lender for the amount so reimbursed.


29.5    EXCEPTIONS


29.5.1  This Clause 29 shall not apply to the extent that the Recovering Lender
        would not, after making any payment pursuant to this Clause, have a
        valid and enforceable claim against the relevant Obligor.


29.5.2  A Recovering Lender is not obliged to share with any other Lender any
        amount which the Recovering Lender has received or recovered as a result
        of taking legal or arbitration proceedings, if:


        (a)    it notified the other Lenders of the legal or arbitration
               proceedings; and


        (b)    the other Lender had an opportunity to participate in those legal
               or arbitration proceedings but did not do so as soon as
               reasonably practicable


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              having received notice or did not take separate legal or
              arbitration proceedings.


30      PAYMENT MECHANICS


30.1    PAYMENTS TO THE AGENT


30.1.1  On each date on which an Obligor or a Lender is required to make a
        payment under a Finance Document, that Obligor or Lender shall make the
        same available to the Agent (unless a contrary indication appears in a
        Finance Document) for value on the due date at the time and in such
        funds specified by the Agent as being customary at the time for
        settlement of transactions in the relevant currency in the place of
        payment.


30.1.2  Payment shall be made to such account in the principal financial centre
        of the country of that currency with such bank as the Agent specifies.


30.2    DISTRIBUTIONS BY THE AGENT


        Each payment received by the Agent under the Finance Documents for
        another Party shall, subject to Clause 30.3 and Clause 30.4 be made
        available by the Agent as soon as practicable after receipt to the Party
        entitled to receive payment in accordance with this Agreement (in the
        case of a Lender, for the account of its Facility Office), to such
        account as that Party may notify to the Agent by not less than five
        Business Days' notice with a bank in the principal financial centre of
        the country of that currency.


30.3    DISTRIBUTIONS TO AN OBLIGOR


        The Agent may (with the consent of the Obligor or in accordance with
        Clause 31) apply any amount received by it for that Obligor in or
        towards payment (on the date and in the currency and funds of receipt)
        of any amount due from that Obligor under the Finance Documents or in or
        towards purchase of any amount of any currency to be so applied.


30.4    CLAWBACK


30.4.1  Where a sum is to be paid to the Agent under the Finance Documents for
        another Party, the Agent is not obliged to pay that sum to that other
        Party (or to enter into or perform any related exchange contract) until
        it has been able to establish to its satisfaction that it has actually
        received that sum.


30.4.2  If the Agent pays an amount to another Party and it proves to be the
        case that the Agent had not actually received that amount, then the
        Party to whom that amount (or the proceeds of any related exchange
        contract) was paid by the Agent shall on demand refund the same to the
        Agent together with interest on that amount from the date of payment to
        the date of receipt by the Agent, calculated by the Agent to reflect its
        cost of funds.


30.5    PARTIAL PAYMENTS


30.5.1  If the Agent receives a payment that is insufficient to discharge all
        the amounts then due and payable by an Obligor under the Finance
        Documents, the Agent shall apply


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        that payment towards the obligations of that Obligor under the Finance
        Documents in the following order:


        (a)    FIRST, in or towards payment pro rata of any unpaid fees, costs
               and expenses of the Agent under the Finance Documents;


        (b)    SECONDLY, in or towards payment pro rata of any accrued interest
               or commission due but unpaid under this Agreement;


        (c)    THIRDLY, in or towards payment pro rata of any principal due but
               unpaid under this Agreement; and


        (d)    FOURTHLY, in or towards payment pro rata of any other sum due but
               unpaid under the Finance Documents.


30.5.2  The Agent shall, if so directed by the Majority Lenders, vary the order
        set out in Clause 30.5.1.


30.5.3  Clauses 30.5.1 and 30.5.2 will override any appropriation made by an
        Obligor.


30.6    NO SET-OFF BY OBLIGORS


        All payments to be made by an Obligor under the Finance Documents shall
        be calculated and be made without (and free and clear of any deduction
        for) set-off or counterclaim.


30.7    BUSINESS DAYS


30.7.1  Any payment which is due to be made on a day that is not a Business Day
        shall be made on the next Business Day in the same calendar month (if
        there is one) or the preceding Business Day (if there is not).


30.7.2  During any extension of the due date for payment of any principal or an
        Unpaid Sum under this Agreement interest is payable on the principal at
        the rate payable on the original due date.


30.8    CURRENCY OF ACCOUNT


30.8.1  Subject to Clause 30.8.2 to 30.8.5, the relevant Base Currency is the
        currency of account and payment for any sum due from an Obligor under
        any Finance Document.


30.8.2  A repayment of a Loan or Unpaid Sum or a part of a Loan or Unpaid Sum
        shall be made in the currency in which that Loan or Unpaid Sum is
        denominated on its due date.


30.8.3  Each payment of interest shall be made in the currency in which the sum
        in respect of which the interest is payable was denominated when that
        interest accrued.


30.8.4  Each payment in respect of costs, expenses or Taxes shall be made in the
        currency in which the costs, expenses or Taxes are incurred.


30.8.5  Any amount expressed to be payable in a currency other than Sterling, US
        Dollars or Canadian Dollars shall be paid in that other currency.


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30.9    CHANGE OF CURRENCY


30.9.1  Unless otherwise prohibited by law, if more than one currency or
        currency unit are at the same time recognised by the central bank of any
        country as the lawful currency of that country, then:


        (a)    any reference in the Finance Documents to, and any obligations
               arising under the Finance Documents in, the currency of that
               country shall be translated into, or paid in, the currency or
               currency unit of that country designated by the Agent (after
               consultation with the Parent); and


        (b)    any translation from one currency or currency unit to another
               shall be at the official rate of exchange recognised by the
               central bank for the conversion of that currency or currency unit
               into the other, rounded up or down by the Agent (acting
               reasonably).


30.9.2  If a change in any currency of a country occurs, this Agreement will, to
        the extent the Agent (acting reasonably and after consultation with the
        Parent) specifies to be necessary, be amended to comply with any
        generally accepted conventions and market practice in the Relevant
        Interbank Market and otherwise to reflect the change in currency.


31      SET-OFF


        A Finance Party may set off any matured obligation due from an Obligor
        under the Finance Documents (to the extent beneficially owned by that
        Finance Party) against any matured obligation owed by that Finance Party
        to that Obligor, regardless of the place of payment, booking branch or
        currency of either obligation. If the obligations are in different
        currencies, the Finance Party may convert either obligation at a market
        rate of exchange in its usual course of business for the purpose of the
        set-off.


32      NOTICES


32.1    COMMUNICATIONS IN WRITING


        Any communication to be made under or in connection with the Finance
        Documents shall be made in writing and, unless otherwise stated, may be
        made by fax or letter.


32.2    ADDRESSES


        The address and fax number (and the department or officer, if any, for
        whose attention the communication is to be made) of each Party for any
        communication or document to be made or delivered under or in connection
        with the Finance Documents is:


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        (a)    in the case of the Parent:-


               Address:   Elphinstone Research Centre
                          Tranent
                          EH33 2NE

               Fax:       01875 613844

               Attention: Walter Nimmo


        (b)    in the case of the Agent:-


               Address:   245 Park Avenue
                          New York
                          NY10167

               Fax:       001 212 272 9804

               Attention: G and A Services


        (c)    in the case of the Security Trustee:-


               Address:   245 Park Avenue
                          New York
                          NY10167

               Fax:       001 212 272 9804


               Attention: G and A Services


        (d)    in the case of the Working Capital Bank:-


               Address:   245 Park Avenue
                          New York
                          NY10167

               Fax:       001 212 272 9804


               Attention: G and A Services


        (e)    in the case of each other Lender or any other Original Obligor,
               that notified in writing to the Agent from time to time,


        or any substitute address, fax number or department or officer as the
        Party may notify to the Agent (or the Agent may notify to the other
        Parties, if a change is made by the Agent) by not less than five
        Business Days' notice.


32.3    DELIVERY


32.3.1  Any communication or document made or delivered by one person to another
        under or in connection with the Finance Documents will only be
        effective:


        (a)    if by way of fax, when received in legible form; or


        (b)    if by way of letter, when it has been left at the relevant
               address or two Business Days after being deposited in the post
               first class postage prepaid in an envelope addressed to it at
               that address; or


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        and, if a particular department or officer is specified as part of its
        address details provided under Clause 32.2, if addressed to that
        department or officer.


32.3.2  Any communication or document to be made or delivered to the Agent will
        be effective only when actually received by the Agent and then only if
        it is expressly marked for the attention of the department or officer
        specified as part of its address details provided under Clause 32.2.


32.3.3  All notices from or to an Obligor shall be sent through the Agent.


32.3.4  Any communication or document made or delivered to the Parent in
        accordance with this Clause will be deemed to have been made or
        delivered to each of the Obligors.


32.4    NOTIFICATION OF ADDRESS, FAX NUMBER AND TELEX NUMBER


        Promptly upon receipt of notification of an address, fax number and
        telex number or change of address, fax number or telex number pursuant
        to Clause 32.2 or changing its own address, fax number or telex number,
        the Agent shall notify the other Parties.


32.5    ENGLISH LANGUAGE


32.5.1  Any notice given under or in connection with any Finance Document must
        be in English.


32.5.2  All other documents provided under or in connection with any Finance
        Document must be:


        (a)    in English; or


        (b)    if not in English, and if so required by the Agent, accompanied
               by a certified English translation and, in this case, the English
               translation will prevail unless the document is a constitutional,
               statutory or other official document.


33      ANNOUNCEMENTS


        Without prejudice to Clause 22.2.1 the Arranger shall be entitled (at
        its own expense) to make any press release, tombstone, advertisement or
        other similar public announcement or otherwise publish any information
        relating to or concerning the Merger or the Facilities as it may wish
        (acting reasonably) provided that the Arranger shall obtain the consent
        of the Parent prior to making any such announcement.


34      CALCULATIONS AND CERTIFICATES


34.1    ACCOUNTS


        In any litigation or arbitration proceedings arising out of or in
        connection with a Finance Document, the entries made in the accounts
        maintained by a Finance Party are prima facie evidence of the matters to
        which they relate.


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34.2    CERTIFICATES AND DETERMINATIONS


        Any certification or determination by a Finance Party of a rate or
        amount under any Finance Document is, in the absence of manifest error,
        conclusive evidence of the matters to which it relates.


34.3    DAY COUNT CONVENTION


        Any interest, commission or fee accruing under a Finance Document will
        accrue from day to day and is calculated on the basis of the actual
        number of days elapsed and a year of 365 days in respect of Sterling
        borrowings and 360 days in respect of US Dollars or Canadian Dollars or,
        in any case where the practice in the Relevant Interbank Market differs,
        in accordance with that market practice.


35      PARTIAL INVALIDITY


        If, at any time, any provision of the Finance Documents is or becomes
        illegal, invalid or unenforceable in any respect under any law of any
        jurisdiction, neither the legality, validity or enforceability of the
        remaining provisions nor the legality, validity or enforceability of
        such provision under the law of any other jurisdiction will in any way
        be affected or impaired.


36      REMEDIES AND WAIVERS


        No failure to exercise, nor any delay in exercising, on the part of any
        Finance Party, any right or remedy under the Finance Documents shall
        operate as a waiver, nor shall any single or partial exercise of any
        right or remedy prevent any further or other exercise or the exercise of
        any other right or remedy. The rights and remedies provided in this
        Agreement are cumulative and not exclusive of any rights or remedies
        provided by law.


37      AMENDMENTS AND WAIVERS


37.1    REQUIRED CONSENTS


37.1.1  Subject to Clause 37.2 any term of the Finance Documents may be amended
        or waived only with the consent of the Majority Lenders and the Obligors
        and any such amendment or waiver will be binding on all Parties.


37.1.2  The Agent may effect, on behalf of any Finance Party, any amendment or
        waiver permitted by this Clause.


37.2    EXCEPTIONS

37.2.1  An amendment or waiver that has the effect of changing or which relates
        to:


        (a)    the definition of "Majority Lenders" in Clause 1.1;


        (b)    an extension to the date of payment of any amount under the
               Finance Documents;


        (c)    a reduction in the Margin or the amount of any payment of
               principal, interest, fees or commission payable;


        (d)    an increase in Commitment;


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   113

        (e)    a change to the Borrowers or Guarantors other than in accordance
               with Clause 25;


        (f)    any provision which expressly requires the consent of all the
               Lenders; or


        (g)    Clause 2.2, Clause 24 or this Clause 37;


        shall not be made without the prior consent of all the Lenders.


37.2.2  An amendment or waiver which relates to the rights or obligations of the
        Agent or the Arranger may not be effected without the consent of the
        Agent or the Arranger.


38      GOVERNING LAW


        This Agreement is governed by English law.


39      ENFORCEMENT


39.1    JURISDICTION OF ENGLISH COURTS


39.1.1  The courts of England have exclusive jurisdiction to settle any dispute
        arising out of or in connection with this Agreement (including a dispute
        regarding the existence, validity or termination of this Agreement) (a
        "DISPUTE").


39.1.2  The Parties agree that the courts of England are the most appropriate
        and convenient courts to settle Disputes and accordingly no Party will
        argue to the contrary.


39.1.3  This Clause 39.1 is for the benefit of the Finance Parties only. As a
        result, no Finance Party shall be prevented from taking proceedings
        relating to a Dispute in any other courts with jurisdiction. To the
        extent allowed by law, the Finance Parties may take concurrent
        proceedings in any number of jurisdictions.


39.2    SERVICE OF PROCESS


        Without prejudice to any other mode of service allowed under any
        relevant law, each Obligor (other than an Obligor incorporated in
        England and Wales):


        (a)    irrevocably appoints the Parent as its agent to accept service on
               its behalf in relation to any proceedings before the English
               courts in connection with any Finance Document; and


        (b)    agrees that failure by such agent to notify the relevant Obligor
               of such server of proceedings will not invalidate the proceedings
               concerned.

THIS AGREEMENT HAS BEEN ENTERED INTO ON THE DATE STATED AT THE BEGINNING OF THIS
AGREEMENT.


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                                   SCHEDULE 1

                              THE ORIGINAL OBLIGORS


 NAME OF ORIGINAL BORROWER  REGISTRATION NUMBER (OR   REGISTERED OFFICE
                              EQUIVALENT, IF ANY)      (OR EQUIVALENT)



Inveresk Research Group     198206                   Elphinstone
Limited                                              Research Centre,
                                                     Tranent, East
                                                     Lothian EH33 2NE

Canada Inc (now renamed     38444811                 1170 Peel Street,
Inveresk Research (Canada)                           Montreal, Quebec,
Inc)                                                 H3B 4S8




NAME OF ORIGINAL GUARANTOR  REGISTRATION NUMBER (OR   REGISTERED OFFICE
                              EQUIVALENT, IF ANY)      (OR EQUIVALENT)


Canada Inc (now renamed     38444811                 1170 Peel Street,
Inveresk Research (Canada)                           Montreal, Quebec,
Inc)                                                 H3B 4S8

Indigo Acquisition Corp                              1209 Orange
                                                     Street,
                                                     Wilmington,
                                                     Delaware

Inveresk Research Holdings  3662374                  Royal London
Limited                                              House, 22/25
                                                     Finsbury Square,
                                                     London EC2A  1DX

Inveresk Research           SC091725                 Elphinstone
International Limited                                Research Centre,
                                                     Tranent, East
                                                     Lothian EH33 2NE

Inveresk Clinical Research  SC109802                 Elphinstone
Limited                                              Research Centre,
                                                     Tranent, East
                                                     Lothian EH33 2NE


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                                   SCHEDULE 2

                              THE ORIGINAL LENDERS







- --------------------------------------------------------------------------------
NAME OF ORIGINAL LENDER                                        BEAR STEARNS
                                                                 CORPORATE
                                                                LENDING INC
- --------------------------------------------------------------------------------
                                                            
Parent Series 1 Refinancing Term Facility Commitment               L20.5m
- --------------------------------------------------------------------------------
Parent Series 2 Refinancing Term Facility Commitment                L5m
- --------------------------------------------------------------------------------
Parent Series 1 Acquisition Term Facility Commitment              US$5.25m
- --------------------------------------------------------------------------------
Parent Series 2 Acquisition Term Facility Commitment              US$2.5m
- --------------------------------------------------------------------------------
Canada Holdco Series 1 Acquisition Term Facility Commitment       US$37.5m
- --------------------------------------------------------------------------------
Canada Holdco Series 2 Acquisition Term Facility Commitment        US$10m
- --------------------------------------------------------------------------------
Capital Expenditure Facility Commitment                            C$15.3m
- --------------------------------------------------------------------------------
Working Capital Facility Commitment                                  L6m
- --------------------------------------------------------------------------------



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                                   SCHEDULE 3

                              CONDITIONS PRECEDENT

                                     PART 1

                      CONDITIONS PRECEDENT TO INITIAL UTILISATION


1       ORIGINAL OBLIGORS


        (a)    A copy of the constitutional documents of each Original Obligor.


        (b)    A copy of a resolution of the board of directors of each Original
               Obligor:


               (i)    approving the terms of, and the transactions contemplated
                      by, the Finance Documents to which it is a party and
                      resolving that it execute the Finance Documents to which
                      it is a party;


               (ii)   authorising a specified person or persons to execute the
                      Finance Documents to which it is a party on its behalf;
                      and


               (iii)  authorising a specified person or persons, on its behalf,
                      to sign and/or despatch all documents and notices
                      (including, if relevant, any Utilisation Request and
                      Selection Notice) to be signed and/or despatched by it
                      under or in connection with the Finance Documents to which
                      it is a party.


        (c)    A specimen of the signature of each person authorised by the
               resolution referred to in paragraph (b) above.


        (d)    A certificate of the Parent (signed by a director) confirming
               that borrowing or guaranteeing, as appropriate, the Total
               Commitments would not cause any borrowing, guaranteeing or
               similar limit binding on any Original Obligor to be exceeded.


        (e)    A certificate of an authorised signatory of the relevant Original
               Obligor certifying that each copy document relating to it
               specified in this Part I of Schedule 3 is correct, complete and
               in full force and effect as at a date no earlier than the date of
               this Agreement.


2       LEGAL OPINIONS


        A legal opinion, in the agreed form, to the Lenders from US counsel for
        US Newco concerning the Tender Offer and Merger Agreement, and including
        without limitation opinions that:


        (a)    US Newco have the corporate power to enter into the Merger
               Documents;


        (b)    the execution and performance of the Merger Documents have been
               duly authorised by all requisite action of the board of directors
               and shareholders of US Newco;


        (c)    US Newco has duly executed and delivered the Merger Documents;


                                      109
   117


        (d)    the Merger Documents are valid and binding obligations of US
               Newco, enforceable in accordance with their terms, subject to
               customary exceptions;


        (e)    execution and performance of the Merger Documents will not
               violate any laws (including without limitation Regulations T, U,
               and X of the Board of Governors of the Federal Reserve System,
               the Investment Company Act of 1940 and the Public Utility Holding
               Company Act of 1935), any formation documents of US Newco or
               Parent, any Merger Document, or any material contract of US Newco
               or Parent, result in the creation of any lien or encumbrance on
               the property of US Newco or Parent, or violate any existing
               order, writ, injunction or decree of any court or governmental
               instrumentality;


        (f)    no consents, approvals, authorisations or orders are required to
               enter into the Merger Documents or take any action in connection
               with the consummation of the transactions required therein.


3       EQUITY DOCUMENTS


        (a)    Certified Copies of the Investment Agreement, Loan Stock
               Instrument and Articles of Association with evidence satisfactory
               to the Agent that the Articles have been adopted except for any
               conditions precedent relating to availability of the Facilities.


        (b)    Evidence that all shares to be issued on or prior to the Drawdown
               Date have been issued fully paid and that all subscription funds
               have been paid to, or to the order of, the Parent.


        (c)    Evidence that all monies to be advanced to the Parent in respect
               of the Loan Stock have been paid to, or to the order of, the
               company.


4       SECURITY


        (a)    UK:


               (i)    a first and only standard security over each Property;


               (ii)   a first and only debenture/bond and floating charge from
                      the Parent, Inveresk Research Holding Limited, Inveresk
                      Research International Limited and Inveresk Clinical
                      Research Limited,


               each in the agreed form;


        (b)    Canada:


               (i)    pledge by Canada Holdco in respect of its shareholding in
                      US Newco in the agreed form;


               (ii)   deed of hypothecation by Canada Holdco in the agreed form;


        (c)    US:


               (i)    US Newco security agreement in the agreed form;


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   118

               (ii)   Inveresk Research North America Inc security agreement in
                      the agreed form; and


               (iii)  pledge/charge by US Newco in respect of the Tender Offer
                      Stock in the agreed form;


        (d)    Intercreditor Agreement in the agreed form.


5       FINANCIAL INFORMATION


        (a)    The Accountant's Report (and the engagement letter in relation to
               it).


        (b)    The Business Plan.


        (c)    The most recent audited financial statements of each Target Group
               Company (other than the Dormant Companies or any Target Group
               Companies incorporated since that date) for the period to 31
               December 2000.


        (d)    The most recent Target Management Accounts for the period ended
               31 December 2000.


        (e)     Management Accounts for the period to 31 December 2000.


6       DUE DILIGENCE REPORTS


        (a)    The Insurance Report.


        (b)    The Legal Report.


        (c)    The Pensions Report.


        (d)    The Environmental Report.


        (e)    The Market Report.


        (f)    Canadian Report on Title.


7       MERGER


        A Certified Copy of the executed Merger Agreement and the Stockholders
        Agreement.


8       INSURANCE


        (a)    A duly certified full, complete and up to date schedule of all
               insurances maintained by each member of the Group, referring to
               the relevant policies.


        (b)    A certificate from a broker approved by the Agent that such
               policies are in full force and effect with premiums paid to date,
               and stating that all the assets of the Group as (and will,
               following Closing remain) insured in the manner specified in the
               Insurance Report.


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9       US


        (a)    good standing certificates in re US incorporated Target Group
               Companies;


        (b)    lien searches against US incorporated Target Group Companies;


        (c)    a completed and executed Federal Reserve Form U-1.


10      MISCELLANEOUS


        A summary of the fees and expenses incurred in connection with the
        Acquisition.



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                                     PART 2

         CONDITIONS PRECEDENT REQUIRED TO BE DELIVERED BY AN ADDITIONAL OBLIGOR


1       An Accession Letter, duly executed by the Additional Obligor and the
        Parent.


2       A copy of the constitutional documents of the Additional Obligor.


3       A copy of a resolution of the board of directors of the Additional
        Obligor:


        (a)    approving the terms of, and the transactions contemplated by, the
               Accession Letter and the Finance Documents and resolving that it
               execute the Accession Letter;


        (b)    authorising a specified person or persons to execute the
               Accession Letter on its behalf; and


        (c)    authorising a specified person or persons, on its behalf, to sign
               and/or despatch all other documents and notices (including, in
               relation to an Additional Borrower, any Utilisation Request or
               Selection Notice) to be signed and/or despatched by it under or
               in connection with the Finance Documents.


4       A specimen of the signature of each person authorised by the resolution
        referred to in paragraph 3 above.


5       A certificate of the Additional Obligor (signed by a director)
        confirming that borrowing or guaranteeing, as appropriate, the Total
        Commitments would not cause any borrowing, guaranteeing or similar limit
        binding on it to be exceeded.


6       A certificate of an authorised signatory of the Additional Obligor
        certifying that each copy document listed in this Part 2 of Schedule 3
        is correct, complete and in full force and effect as at a date no
        earlier than the date of the Accession Letter.


7       A copy of any other Authorisation or other document, opinion or
        assurance which the Agent considers to be necessary or desirable in
        connection with the entry into and performance of the transactions
        contemplated by the Accession Letter or for the validity and
        enforceability of any Finance Document.


8       If available, the latest audited financial statements of the Additional
        Obligor.


9       A legal opinion of McGrigor Donald, legal advisers to the Arranger and
        the Agent in Scotland and England.


10      If the Additional Obligor is incorporated in a jurisdiction other than
        Scotland or England and Wales, a legal opinion of the legal advisers to
        the Agent in the jurisdiction in which the Additional Obligor is
        incorporated.


11      If the proposed Additional Obligor is incorporated in a jurisdiction
        other than England and Wales or Scotland, evidence that the process
        agent specified in Clause 39.2, if not an Obligor, has accepted its
        appointment in relation to the proposed Additional Obligor.


                                      113
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                                   SCHEDULE 4
                               UTILISATION REQUEST
From:    [Borrower]
To:      [Agent]
Dated:

Dear Sirs
             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")


1          We wish to borrow a Loan on the following terms:



                                                         
           Proposed Utilisation Date:                       [   ] (or, if that is not a Business
                                                            Day, the next Business Day)

           Facility to be utilised:                         [Relevant Series 1 Term Facility/Series 2 Term
                                                            Facility/Capital Expenditure Facility]

           Amount:                                          [   ] or, if less, the Available Facility

           Interest Period:                                 [   ]


2          We confirm that each condition specified in Clause 0 is satisfied on
           the date of this Utilisation Request.


3          The proceeds of this Loan should be credited to [account].


4          This Utilisation Request is irrevocable.


Yours faithfully

 .......................................
authorised signatory for
[name of relevant Borrower]


                                      114
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                                   SCHEDULE 5
                                SELECTION NOTICE
From:    [Borrower]
To:      [Agent]
Dated:

Dear Sirs
             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")


1          We refer to the following [ ] Loan[s] with an Interest Period ending
           on [ ]


           [We request that the next Interest Period for the above
           [                        ] Loan[s] is [     ]].


2          This Selection Notice is irrevocable.


Yours faithfully


 .....................................
authorised signatory for
[the Parent on behalf of]
[name of relevant Borrower]


                                      115
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                                   SCHEDULE 6
                             MANDATORY COST FORMULA

1          The Mandatory Costs percentage rate is an addition to the interest
           rate on an Advance to compensate any Lender for the cost attributable
           to an Advance resulting from the imposition from time to time under
           or pursuant to the Lender of England Act 1998 (the "Act") and/or by
           the Lender of England and/or the Financial Services Authority (the
           "FSA") (or other United Kingdom governmental authorities or agencies)
           of a requirement to place non interest-bearing or Special Deposits
           (whether interest bearing or not) with the Lender of England and/or
           pay fees to the FSA calculated by reference to liabilities used to
           fund the Advance.


           The Mandatory Costs percentage rate will be the rate determined by
           the Agent to be equal to the arithmetic mean (rounded upwards if
           necessary to four decimal places) of the respective rates notified by
           each of the Reference Lenders to the Agent as the rate resulting from
           the application (as appropriate) of the following formulae:


           in relation to Sterling Advances:

                                XL+S(L-C)+Fx0.01
                                ----------------
                                   100-(X+S)

           in relation to other Advances:

                                     Fx0.01
                                     ------
                                      300

           where:


           X      is the percentage of the Eligible Liabilities (in excess of
                  any stated minimum) by reference to which such Reference
                  Lender is required under or pursuant to the Act to maintain
                  cash ratio deposits with the Lender of England.


           L      is the percentage rate at which sterling deposits for the
                  relevant period are offered by such Reference Lender to
                  leading banks in the London Interbank Market at or about 11.00
                  am on that day.


           F      is the rate of charge payable by such Reference Lender to the
                  FSA pursuant to paragraph 2.02 or 2.03 (as appropriate) of the
                  Fees Regulations (but where for this purpose, the figure at
                  paragraph 2.02b or 2.03b (as appropriate) shall be deemed to
                  be zero) and expressed in pounds per L1 million of the Fee
                  Base of the Reference Lender.


           S      is the level of interest-bearing Special Deposits, expressed
                  as a percentage of Eligible Liabilities, which such Reference
                  Lender is required to maintain by the Lender of England (or
                  other United Kingdom governmental authorities or agencies).


           C      is the percentage rate per annum payable by the Lender of
                  England to such Reference Lender on Special Deposits.


                                      116
   124
2          For the purposes of this Part of the Schedule:


           (a)       the terms "Eligible Liabilities" and "Special Deposits"
                     shall bear the meanings ascribed to them under or pursuant
                     to the Act or by the Lender of England (as may as
                     appropriate) on the day of application of the formula;


           (b)       Fee Base has the meaning ascribed to it for the purpose of,
                     and shall be calculated in accordance with, the Fees
                     Regulations;


           (c)       Fees Regulations means, as appropriate, either:


                     (i)        the Banking Supervision (Fees) Regulations 1999;
                                or


                     (ii)       such regulations as from time to time may be in
                                force,


                     relating to the payment of fees for banking supervision;


           (d)       the Mandatory Costs rate attributable to an Advance or
                     other sum for any period shall be calculated at or about
                     11.00 am (London time) on the first day of such period for
                     the duration of such period;


           (e)       if any Reference Lender fails to notify any such rate to
                     the Agent, the Mandatory Costs rate shall be determined on
                     the basis of the rate(s) notified to the Agent by the
                     remaining Reference Lender(s);


           (f)       the determination of the Mandatory Costs rate in relation
                     to any period shall, in the absence of manifest error, be
                     conclusive and binding on all parties hereto;


           (g)       X, L, S and C are to be expressed in the above formula as
                     numbers and not as percentages. A negative result obtained
                     from subtracting C from L should be counted as zero;


           (h)       if there is any change in circumstances (including the
                     imposition of alternative or additional requirements) which
                     in the reasonable opinion of the Agent renders or will
                     render either of the above formulae (or any element thereof
                     or any defined term used therein), inappropriate or
                     inapplicable, the Agent (following consultation with the
                     Parent and an Instructing Group) shall be entitled to vary
                     the same. Any such variation shall, in the absence of
                     manifest error, be conclusive and binding on all parties
                     and shall apply from the date specified in such notice;


           (i)       any reference to a provision of any statute, directive,
                     order or regulation herein is a reference to that provision
                     as amended or re-enacted from time to time;


           (j)       any reference to Lender or Reference Lender in this Part of
                     the Schedule shall be deemed to include a reference to any
                     holding company of such Lender or Reference Lender to the
                     extent to which such holding company incurs any Mandatory
                     Costs.


                                      117
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                                   SCHEDULE 7
                          FORM OF TRANSFER CERTIFICATES


To:      [            ] as Agent
From:    [The Existing Lender] (the "EXISTING LENDER") and [The New Lender]
         (the "NEW LENDER")
Dated:

             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")


1          We refer to Clause 24.6:


           (a)       The Existing Lender and the New Lender agree to the
                     Existing Lender and the New Lender transferring by novation
                     all or part of the Existing Lender's Commitment, rights and
                     obligations referred to in the Schedule in accordance with
                     Clause 24.6.


           (b)       The proposed Transfer Date is [            ].


           (c)       The Facility Office and address, fax number and attention
                     details for notices of the New Lender for the purposes of
                     Clause 32.2 are set out in the Schedule.


2          The New Lender expressly acknowledges the limitations on the Existing
           Lender's obligations set out in paragraph (c) of Clause 24.5.


3          This Transfer Certificate is governed by English law.


4          Schedule of Commitment/rights and obligations to be transferred.


               COMMITMENT/RIGHTS AND OBLIGATIONS TO BE TRANSFERRED

                            [insert relevant details]
         [Facility Office address, fax number and attention details for
                   notices and account details for payments,]



                                                             
           [Existing Lender]                                    [New Lender]
           By:..............................................    By:.............................................
                     Director/Authorised Signatory                         Director/Authorised Signatory


           This Transfer Certificate is accepted by the Agent and the Transfer
           Date is confirmed as [ ].


           [Agent]


           By:.............................................
                    Director/Authorised Signatory


                                      118
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                                   SCHEDULE 8
                            FORM OF ACCESSION LETTER

To:      [        ] as Agent
From:    [Subsidiary] and [Parent]
Dated:
Dear Sirs
             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")


1          [Subsidiary] agrees to become an Additional [Borrower]/[Guarantor]
           and to be bound by the terms of the Facilities Agreement as an
           Additional [Borrower]/[Guarantor] pursuant to
           [Clause 25.2]/[Clause 25.4] of the Facilities Agreement. [Subsidiary]
           is a company duly incorporated under the laws of [name of relevant
           jurisdiction].


2          [Subsidiary's] administrative details are as follows:


           Address:


           Fax No:


           Attention:


3          [The liability of [Subsidiary] as a Guarantor shall be limited to the
           greater of:-


3.1        the highest amount the payment of which by [Subsidiary] is permitted
           as determined as of the date hereof in accordance with section 123.66
           of the Companies Act (Quebec); and


3.2        the highest amount the payment of which by [Subsidiary] is permitted
           as determined as of the date of payment in accordance with section
           123.66 of the Companies Act (Quebec).] [NOTE: TO BE INCLUDED ONLY
           WHEN QUEBEC INCORPORATED GROUP MEMBER BECOMING ADDITIONAL GUARANTOR]


4          This letter is governed by English law.



           [This Guarantor Accession Letter is entered into by deed.]


           [Parent]                                  [Subsidiary]


                                      119
   127
                                   SCHEDULE 9
                           FORM OF RESIGNATION LETTER

To:      [       ] as Agent
From:    [resigning Obligor] and Parent
Dated:
Dear Sirs
             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")


1          Pursuant to [Clause 25.3]/[Clause 25.6], we request that [resigning
           Obligor] be released from its obligations as a [Borrower]/[Guarantor]
           under the Facilities Agreement.


2          We confirm that:


           (a)       no Default is continuing or would result from the
                     acceptance of this request; and


           (b)       [[resigning Obligor] is under no actual or contingent
                     obligations as a Borrower under any Finance Documents]/[all
                     the Finance Parties have consented to the request that
                     [resigning Obligor] ceases to be a Guarantor].


3          This letter is governed by English law.


                                                          
           For and on behalf of                              For and on behalf of
           [Parent]                                          [Subsidiary]


           By:........................................       By:.............................................
                      Director/Authorised Signatory                   Director/Authorised Signatory


                                       120
   128
                                   SCHEDULE 10
                         FORM OF COMPLIANCE CERTIFICATE

To:      [       ] as Agent
From:    [Company]
Dated:
Dear Sirs

             INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT
               DATED 22 FEBRUARY 2001 (THE "FACILITIES AGREEMENT")



1          We refer to the Facilities Agreement. This is a Compliance
           Certificate.


2          We confirm that:  [Insert details of covenants to be certified]


3          [We confirm that no Default is continuing.]*


Signed:      .....................                [.....................

               Director                           Director
               Of                                 of
               [Parent]                           [Parent]]

[insert applicable certification language]

 ............................
for and on behalf of
[name of auditors of the Parent]

- ----------
* If this statement cannot be made, the certificate should identify any Default
that is continuing and the steps, if any, being taken to remedy it.


                                      121
   129
                                   SCHEDULE 11
                                   TIMETABLES



                            LOANS IN US$              LOANS IN L                LOANS IN C$
                            ------------              ----------                -----------
                                                                       
Delivery of a duly          such time as the Agent    such time as the Agent    such time as the Agent
completed Utilisation       (acting reasonably) may   (acting reasonably) may   (acting reasonably) may
Request (Clause 4.1.1) or   specify*                  specify*                  specify*
a Selection Notice
(10.1.1)

Agent notifies Lenders of   such time as the Agent    such time as the Agent    such time as the Agent
the Loan in accordance      (acting reasonably) may   (acting reasonably) may   (acting reasonably) may
with clause 4.1.4.3         specify*                  specify*                  specify*
(Lenders' participation)

LIBOR is fixed              Quotation Day as of       Quotation Day as of       Quotation Day as of
                            11.00 am London time      11.00 am London time      11.00 am London time


*    For the purposes of this Schedule 11 such time period may not in any
     circumstances exceed more than four Business Days.


                                      122
   130
                                   SCHEDULE 12
                           POST MERGER GROUP STRUCTURE


                                      123
   131
                                  [FLOW CHART]


                                      124
   132
                                   SCHEDULE 13
                            FORM OF GUARANTEE REQUEST

To:      [WORKING CAPITAL BANK]

From:    [BORROWER]

[date]


Dear Sirs,

INVERESK RESEARCH GROUP LIMITED - FACILITIES AGREEMENT DATED 22 FEBRUARY 2001
(THE "FACILITIES AGREEMENT")

Terms defined in the Facilities Agreement have the same meaning in this request.

We request a Bank Guarantee to be issued under the Working Capital Facility in
the form attached.


1          Issue Date:


2          Amount of Bank Guarantee;


3          Purpose of Bank Guarantee;


4          Expiry date of Bank Guarantee;

We confirm that today and on the Issue Date:


(a)      the representations in Clause 0 to be repeated are and will be correct;
         and


(b)      no Default has occurred and is continuing or will occur on the issue of
         the Bank Guarantee.


SIGNED



For and on behalf of
* [BORROWER]

(a company incorporated in [  ] under number [  ])


                                      125
   133
                                   SCHEDULE 14
                             CLINICAL GROUP MEMBERS


                                      126
   134
                                   SCHEDULE 15
                                KEY MAN INSURANCE



MANAGEMENT TEAM MEMBER                    AMOUNT                      PERIOD
- ----------------------                    ------                      ------
                                                                
Stewart G Leslie                          L250,000                    3 years

Nick Thornton                             L500,000                    3 years
(or any replacement CEO)

Dr Walter S Nimmo                         L1,000,000                  3 years

Mike Ankcorn                              L500,000                    3 years

Paul Bancroft                             L250,000                    3 years

Dr Ian P Sword                            L500,000                    3 years



                                      127
   135
                                   SCHEDULE 16
                            PART 1 MATERIAL COMPANIES


Inveresk Research Group Limited


Inveresk Research International Limited


Inveresk Clinical Research Limited


Inveresk Research Holdings Limited


Inveresk Research (North America) Inc


                                      128
   136
                                   SCHEDULE 16
                            PART 2 DORMANT COMPANIES



                                      129
   137
                                   SCHEDULE 16
                            PART 3 OVERSEAS COMPANIES

Inveresk Research (North America) Inc


Inveresk Research (Canada) Inc


Indigo Acquisition Corp.



                                      130
   138
                                   SIGNATORIES





INVERESK RESEARCH GROUP LIMITED


By Walter S Nimmo





INVERESK RESEARCH (CANADA) INC


By Walter S Nimmo





INDIGO ACQUISITION CORP


By Walter S Nimmo





INVERESK RESEARCH HOLDINGS LIMITED


By Walter S Nimmo





INVERESK RESEARCH INTERNATIONAL LIMITED


By Walter S Nimmo





INVERESK CLINICAL RESEARCH LIMITED


By Walter S Nimmo





BEAR STEARNS CORPORATE LENDING INC


By an authorised signatory


                                      131