EXHIBIT 10.2 AMENDMENT TO SECURITYHOLDERS AGREEMENT THIS AMENDMENT (the "Amendment") is made as of the 21st day of November, 2000 among Endeavor Pharmaceuticals, Inc. ("Endeavor"), the undersigned stockholders of Endeavor (the "Stockholders"), and the Origin Entities (as defined below). Whereas, pursuant to that certain Series E Preferred Stock Purchase Agreement (the "Series E Agreement") dated August 8, 2000 among Endeavor and the purchasers identified in Schedule 1 thereto (the "Purchasers"), as amended by that certain Amendment to Series E Preferred Stock Purchase Agreement dated November 21, 2000 among Endeavor, the Purchasers and the Origin Entities, the Origin Entities will purchase 505,305 shares of Series E Preferred Stock from Endeavor in the Second Closing for $19.79 per share; WHEREAS, capitalized but undefined terms used herein shall have the meanings ascribed to such terms in the Series E Agreement; WHEREAS, in connection with the Second Closing, Endeavor will issue to Sutro a warrant to purchase up to 6,316 shares of Common Stock at an exercise price of $21.77 per share, subject to adjustment under the terms and conditions of such warrant; WHEREAS, Section 11.2 of that certain Securityholders Agreement dated August 8, 2000 between Endeavor and those securityholders signatories thereto or otherwise bound thereby, including the Stockholders, as in effect on the date hereof (the "Securityholders Agreement"), provides that the holders of 662/3% of the Shares (as defined in the Securityholders Agreement) may waive the rights of all securityholders under any provision of such agreement or amend any provision thereof if the waiver or amendment is in writing, identifies the specific purpose for which it is given, and is signed by (1) the holders of 662/3% of the Shares, and (2) so long as each owns any Shares, each of GS Capital Partners II, L.P., GS Capital Partners II Offshore, L.P., Goldman, Sachs & Co. Verwaltungs GmbH, Stone Street Fund 1995, L.P., Bridge Street Fund 1995, L.P. (collectively, the "Goldman Entities"), MPM BioVentures II, L.P., MPM BioVentures II-QP, L.P., MPM BioVentures GmbH & Co. Parallel-Beteiligungs KG, MPM Asset Management Investors 2000 B LLC (collectively, the "MPM Entities"), Applied Analytical Industries, Inc., Schering Berlin Venture Corporation, Noro-Moseley Partners II, L.P. and Wakefield Group Limited Partnership; WHEREAS, the Stockholders hold 662/3% or more of the Shares; WHEREAS, in connection with the Second Closing, the following entities are willing to become parties to, and Securityholders under, the Securityholders Agreement and be bound by the terms and conditions thereof: Origin Investors, L.P., No Margin Fund, L.P., Duquesne Fund, L.P., Steeler Fund, Ltd., Aswin Continental, S.A., and Quantum Partners LDC (collectively, the "Origin Entities"); WHEREAS, the Stockholders are willing to consent to the Origin Entities becoming parties to the Securityholders Agreement upon the Origin Entities agreeing in writing to be bound by the terms and conditions thereof; WHEREAS, the parties hereto desire to enter into this Amendment to amend the Securityholders Agreement to reflect the transactions that will occur in connection with the Second Closing; NOW, THEREFORE, in consideration of the covenants, promises and representations set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 1. The Origin Entities are hereby made parties to the Securityholders Agreement and Securityholders thereunder, and the Origin Entities agree hereby to be bound, and are hereby bound, by all of the terms and conditions contained in the Securityholders Agreement, as amended by this Amendment. 2. Schedule 1 to the Securityholders Agreement is hereby deleted and replaced in its entirety in the form attached hereto as Schedule 1, reflecting the Origin Entities as Securityholders and setting forth opposite the name of each Securityholder the aggregate number of securities held by such Securityholder immediately following the Second Closing to which the Securityholders Agreement applies. 3. The definition of Registrable Securities set forth in Section 1 of the Securityholders Agreement is hereby deleted and replaced in its entirety as follows: "Registrable Securities" means (i) shares of Common Stock issued or issuable upon conversion of shares of Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, or Series E Preferred Stock, (ii) shares of Common Stock issued or issuable upon exercise of the Sutro Warrant, the Robinson-Humphrey Warrants or the Key Employee Warrants, (iii) any shares of Common Stock acquired by any Securityholder pursuant to this Agreement, and (iv) any shares of Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange for, or in replacement of, the shares of Common Stock referenced in (i), (ii) and (iii) above, excluding in all cases, however, any securities sold (y) pursuant to a registration statement that has been declared effective and such securities have been disposed of pursuant to such effective registration statement, or (z) in a transaction in which such Registrable Securities are sold pursuant to Rule 144 (or any similar provision then in force) under the Securities Act. For purposes of this Agreement, a Person will be deemed to be a holder of Registrable Securities whenever such Person is the holder of record or has the right to acquire such Registrable Securities (by conversion or otherwise but disregarding any restrictions upon the exercise of such right), whether or not such acquisition has actually been effected. 4. The definition of Sutro Warrant set forth in Section 1 of the Securityholders Agreement is hereby deleted and replaced in its entirety as follows: 2 "Sutro Warrant" means the "Sutro Warrant" as defined in the Series E Purchase Agreement, subject to adjustment under Section 2.5 thereof, and the warrant to purchase up to 6,316 shares of Common Stock at an exercise price of $21.77 per share, subject to adjustment under the terms and conditions of such warrant, issued by the Company to Sutro in connection with the "Second Closing" as defined in the Series E Purchase Agreement. 5. Section 1 of the Securityholders Agreement is hereby amended to add the following definition: "Subsequent Offering" has the meaning assigned to such term in Section 7.12. 6. Section 7.4 of the Securityholders Agreement is hereby deleted in its entirety. 7. Section 7.12 of the Securityholders Agreement is hereby deleted and replaced in its entirety as follows: 7.12 "Market Stand-Off" Agreement. Each holder of Registrable Securities hereby agrees that it will not, without the prior written consent of the Company and the managing underwriter, during each of the one hundred and eighty (180) day periods (or such lesser periods as may be specified by the Company and the managing underwriter) commencing on the date of the final prospectus relating to the Company's Initial Public Offering and the effective date of the first public offering of equity securities of the Company in which Registerable Securities are included following the Initial Public Offering (the "Subsequent Offering"), (i) lend, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock (whether such shares or any such securities are then owned by such holder or are thereafter acquired), or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of the Common Stock, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Common Stock or such other securities, in cash or otherwise. The foregoing provisions of this Section 7.12 shall apply only to the Company's Initial Public Offering and the Subsequent Offering, shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, and shall only be applicable to the holders of Registrable Securities if officers, directors and greater than five percent (5%) stockholders of the Company enter into similar agreements. The underwriters in connection with the Company's Initial Public Offering and Subsequent Offering are intended third party beneficiaries of this Section 7.12 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Notwithstanding the foregoing, nothing in this Section 7.12 shall prevent the undersigned from making a transfer of any Common Stock that was listed on a national stock exchange or 3 traded on Nasdaq at the time it was acquired by the holder or was acquired by the undersigned pursuant to Rule 144A of the Securities Act, including any shares acquired in the Company's Initial Public Offering or Subsequent Offering. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to the Registrable Securities of each holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 8. Except as otherwise provided herein, the Securityholders Agreement shall remain in full force and effect. 9. This Amendment may be executed in counterparts, all of which together shall constitute one and the same instrument. 10. This amendment shall be governed by and construed in accordance with the laws of the State of Delaware without giving effect to the principles of conflicts of laws. 11. If any one or more of the provisions contained herein, or the application thereof in any circumstance, is held invalid, illegal or unenforceable in any respect for any reason, the validity, legality and enforceability of any such provision in every other respect and of the remaining provisions hereof shall not be in any way impaired, unless the provisions held invalid, illegal or unenforceable shall substantially impair the benefits of the remaining provisions hereof. [Remainder of this page intentionally left blank - signature pages to follow] 4 IN WITNESS WHEREOF, each of the undersigned has executed, or has caused to be executed, this Amendment as of the date first written above. ENDEAVOR PHARMACEUTICALS, INC. By: /s/ R. Forrest Waldon -------------------------------- Name: R. Forrest Waldon Title: President Date: ------------ ORIGIN CAPITAL MANAGEMENT, LLC By: /s/ -------------------------------- Name: Title: Date: ------------ Stockholders NORO-MOSELEY PARTNERS II, L.P. By: Moseley & Company, II its General Partner By: /s/ Charles D. Moseley -------------------------------- Name: Charles D. Moseley Title: President Date: ------------ WAKEFIELD GROUP LIMITED PARTNERSHIP By: /s/ -------------------------------- Name: Title: Date: ------------ SCHERING BERLIN VENTURE CORPORATION By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE APPLIED ANALYTICAL INDUSTRIES, INC. By: /s/ -------------------------------- Name: Title: Date: ------------ GS CAPITAL PARTNERS II, L.P. By: GS Advisors, L.P. its general partner By: /s/ -------------------------------- Name: Title: Date: ------------ GS CAPITAL PARTNERS II OFFSHORE, L.P. By: GS Advisors, II (Cayman), L.P. its General Partner By: GS Advisors II, Inc. its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ GOLDMAN SACHS & CO. VERWALTUNGS GmbH By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE STONE STREET FUND 1995, L.P. By: Stone Street Value Corp. its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ BRIDGE STREET FUND 1995, L.P. By: Stone Street Value Corp. its Managing General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ FREDERICK D. SANCILIO, Ph.D. /s/ Frederick D. Sancilio - ------------------------------- Frederick D. Sancilio, Ph. D. Date: ------------ WATERS FOUNDATION By: /s/ James L. Waters -------------------------------- Name: James L. Waters Title: Trustee Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE MPM BIOVENTURES II, L.P. By: MPM Asset Management II, L.P. its General Partner By: MPM Asset Management II LLC its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ MPM BIOVENTURES II-QP, L.P. By: MPM Asset Management II, L.P. its General Partner By: MPM Asset Management II LLC its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ MPM BIOVENTURES GMBH & CO. PARALLEL-BETEILIGUNGS KG By: MPM Asset Management II, L.P. its General Partner By: MPM Asset Management II LLC its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE MPM ASSET MANAGEMENT INVESTORS 2000 B LLC By: /s/ -------------------------------- Name: Title: Date: ------------ ALTA BIOPHARMA PARTNERS, L.P. By: Alta BioPharma Management, LLC By: /s/ -------------------------------- Name: Title: Managing Director Date: ------------ ENDEAVOR PHARMACEUTICALS CHASE PARTNERS (ALTA BIO), LLC By: Alta/Chase BioPharma Management, LLC By: /s/ -------------------------------- Name: Title: Member Date: ------------ ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC By: /s/ -------------------------------- Name: Title: Under Power of Attorney Date: ------------ SUTRO INVESTMENT PARTNERS VI LLC By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE SUTRO & CO. INCORPORATED By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE ORIGIN INVESTORS, L.P. By: Origin Capital Management, LLC its General Partner By: /s/ -------------------------------- Name: Title: Date: ------------ NO MARGIN FUND, L.P. By: Origin Capital Management, LLC its Manager By: /s/ -------------------------------- Name: Title: Date: ------------ DUQUESNE FUND, L.P. By: Origin Capital Management, LLC its Manager By: /s/ -------------------------------- Name: Title: Date: ------------ STEELER FUND, L.P. By: Origin Capital Management, LLC its Manager By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE ASWIN CONTINENTAL, S.A. By: Origin Capital Management, LLC its Manager By: /s/ -------------------------------- Name: Title: Date: ------------ QUANTUM PARTNERS LDC By: /s/ -------------------------------- Name: Title: Date: ------------ AMENDMENT TO SECURITYHOLDERS AGREEMENT - SIGNATURE PAGE Schedule 1 to Securityholders Agreement dated August 8, 2000, as amended November 21, 2000 Name and Address of Number of Securityholder Security Held Shares - ------------------- ------------- --------- Stock: Alta BioPharma Partners, L.P. Series E Preferred Stock 235,567 One Embarcadero Center, Suite 4050 San Francisco, CA 94111 Alta Embarcadero BioPharma, LLC Series E Preferred Stock 8,879 One Embarcadero Center, Ste. 4050 San Francisco, CA 94111 Applied Analytical Series C Preferred Stock 651,728 Industries, Inc. 1206 North 23rd St. Wilmington, NC 28405 Attention: _______________________ Aswin Continental, S.A. Series E Preferred Stock 78,827 180 Maiden Lane, 8th Floor New York, NY 10038 Attention: Jeanette Fazioli and Sam Kobulnick Thomas J. Asher Series A Preferred Stock 4,073 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Bridge Street Fund 1995, L.P. Series D Preferred Stock 6,206 c/o Goldman, Sachs & Co. Series E Preferred Stock 14,725 85 Broad Street New York, NY 10004 Attention: Joseph H. Gleberman Mark A. Chancey Series A Preferred Stock 3,258 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 J. Storey Charbonnet Series A Preferred Stock 4,073 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 John C. Dancu Series A Preferred Stock 6,517 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Roderick A. Dowling Series A Preferred Stock 8,146 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Duquesne Fund, L.P. Series E Preferred Stock 10,106 180 Maiden Lane, 8th Floor New York, NY 10038 Attention: Jeanette Fazioli and Sam Kobulnick Endeavor Pharmaceuticals Chase Series E Preferred Stock 134,531 Partners (Alta Bio), LLC One Embarcadero Center, Ste. 4050 San Francisco, CA 94111 Reynolds C. Faulkner Series A Preferred Stock 4,073 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 GS Capital Partners II, L.P. Series D Preferred Stock 73,546 c/o Goldman, Sachs & Co. Series E Preferred Stock 174,495 85 Broad Street New York, NY 10004 Attention: Joseph H. Gleberman GS Capital Partners II Series D Preferred Stock 29,237 Offshore, L.P. Series E Preferred Stock 69,368 c/o Goldman, Sachs & Co. 85 Broad Street New York, NY 10004 Attention: Joseph H. Gleberman Goldman, Sachs & Co. Series D Preferred Stock 2,712 Verwaltungs GmbH Series E Preferred Stock 6,436 c/o Goldman, Sachs & Co. 85 Broad Street New York, NY 10004 Attention: Joseph H. Gleberman C. MacLaine Kenan Series A Preferred Stock 4,073 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Garrison M. Kitchen Series A Preferred Stock 3,258 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 John D. Lowenberg Series A Preferred Stock 8,146 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Edward D. McCrady Series A Preferred Stock 1,629 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Nicholas A. Merrick Series A Preferred Stock 1,629 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 MPM Asset Management Investors Series E Preferred Stock 15,664 2000 B LLC One Cambridge Center, 9th Floor Cambridge, Massachusetts 02142 MPM BioVentures II, L.P. Series E Preferred Stock 75,088 One Cambridge Center, 9th Floor Cambridge, Massachusetts 02142 MPM BioVentures II-QP, L.P. Series E Preferred Stock 680,343 One Cambridge Center, 9th Floor Cambridge, Massachusetts 02142 MPM BioVentures GmbH & Co. Series E Preferred Stock 239,514 Parallel-Beteiligungs KG One Cambridge Center, 9th Floor Cambridge, Massachusetts 02142 No Margin Fund, L.P. Series E Preferred Stock 4,548 180 Maiden Lane, 8th Floor New York, NY 10038 Attention: Jeanette Fazioli and Sam Kobulnick Noro-Moseley Series A Preferred Stock 244,398 Partners II, L.P. Series E Preferred Stock 26,540 4200 Northside Parkway Building 9 Atlanta, GA 30327 Attention: Charles D. Moseley George P. Novak Series A Preferred Stock 16,293 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Origin Investors, L.P. Series E Preferred Stock 159,171 120 Kearny Street, Suite 3300 San Francisco, CA 94104 Attention: Swift C. Barnes Quantum Partners LDC Series E Preferred Stock 227,893 180 Maiden Lane, 8th Floor New York, NY 10038 Attention: Jeanette Fazioli and Sam Kobulnick Alexander Purdie Series A Preferred Stock 8,146 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Frederick D. Sancilio, Ph.D. Series E Preferred Stock 38,927 2332 Ocean Point Drive Wilmington, NC 28405 Jerome D. Sands Series A Preferred Stock 8,146 c/o The Robinson-Humphrey Company, Inc. 3333 Peachtree Road, NE Atlanta, GA 30326 Schering Berlin Series B Preferred Stock 162,932 Venture Corporation Series E Preferred Stock 17,693 110 East Hanover Avenue P.O. Box 567 Cedar Hills, NJ 07927 Attention: John Nicholson Steeler Fund, L.P. Series E Preferred Stock 24,760 180 Maiden Lane, 8th Floor New York, NY 10038 Attention: Jeanette Fazioli and Sam Kobulnick Stone Street Fund 1995, L.P. Series D Preferred Stock 5,515 c/o Goldman, Sachs & Co. Series E Preferred Stock 13,084 85 Broad Street New York, NY 10004 Attention: Joseph H. Gleberman Sutro Investment Partners VI LLC Series E Preferred Stock 12,632 11150 Santa Monica Boulevard Suite 1500 Los Angeles, CA 90025 Attention: Mark Tunney Wakefield Group Limited Series A Preferred Stock 244,398 Partnership Series E Preferred Stock 26,540 1110 East Morehead St. Charlotte, NC 28204 Attention: Thomas C. Nelson Waters Foundation Series E Preferred Stock 31,849 47 New York Avenue Framingham, MA 01701 Options: Angela D. Davis Options exercisable for Common Stock 3,000 3507 Tall Pine Court Wilmington, NC 28409 Michelle C. Hughes Options exercisable for Common Stock 1,100 7401 Montfaye Court Wilmington, NC 28411 Dr. Thomas W. Leonard Options exercisable for Common Stock 72,018 2201 South Live Oak Parkway Wilmington, NC 28403 Stephen F. Rizzo Options exercisable for Common Stock 72,018 105 MacKenzie Drive Wilmington, NC 28409 Christopher Smith Options exercisable for Common Stock 18,000 7950 Old River Road Burgaw, NC 28425 Dr. Wulf H. Utian Options exercisable for Common Stock 11,144 27500 Cedar Road Beachwood, OH 44122 R. Forrest Waldon Options exercisable for Common Stock 144,037 6310 Seamist Court Wilmington, NC 28409 Warrants: Ashok J. Desai Warrant exercisable for Common Stock 500 3412 Hampshire Drive Wilmington, NC 28409 Steven A. Fontana, Esq. Warrant exercisable for Common Stock 300 4708 Wedgefield Court Wilmington, NC 28409 Mark P. Hayes, Ph.D. Warrant exercisable for Common Stock 300 1302 Hawthorne Road Wilmington, NC 28403 Edward N. Hill Warrant exercisable for Common Stock 300 2709 Willow Street Wilmington, NC 28405 Edward N. Hill Warrant exercisable for Common Stock 150 2709 Willow Street Wilmington, NC 28405 Glen Meyer, Ph.D. Warrant exercisable for Common Stock 200 6117 Clairidge Road Wilmington, NC 28403 The Robinson-Humphrey Robinson-Humphrey Warrant 13,500 Company, Inc. exercisable for Common Stock 3333 Peachtree Road, NE Atlanta, GA 30326 Attention: Charles H.- Ogburn Dean G. Shirazi, Ph.D. Warrant exercisable for Common Stock 500 6906 Myric Court Wilmington, NC 28411 Christopher Smith Warrant exercisable for Common Stock 400 7950 Old River Road Burgaw, NC 28425 Sutro & Co. Incorporated Warrant exercisable for 70,111 11150 Santa Monica Boulevard Common Stock Suite 1500 Los Angeles, CA 90025 Attention: Mark Tunney Sutro & Co. Incorporated Warrant exercisable for 6,316 11150 Santa Monica Boulevard Common Stock Suite 1500 Los Angeles, CA 90025 Attention: Mark Tunney James Swarbrick Warrant exercisable for Common Stock 500 106 Blue Heron Lane Hampstead, NC 28443 William H. Underwood Warrant exercisable for Common Stock 500 1518 Portsmouth Drive Wilmington, NC 28411 Daniel White Warrant exercisable for Common Stock 300 3506 Melissa Court Wilmington, NC 28409 Daniel White Warrant exercisable for Common Stock 200 3506 Melissa Court Wilmington, NC 28409 Robert R. Whittle, Ph.D. Warrant exercisable for Common Stock 500 2709 Willow Street Wilmington, NC 28403 Robert R. Whittle, Ph.D. Warrant exercisable for Common Stock 250 2709 Willow Street Wilmington, NC 28403