Exhibit 32.1

          CERTIFICATION OF CHAIRMAN AND CHIEF EXECUTIVE OFFICER OF ENDO
                       PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report on Form 10-K of Endo Pharmaceuticals
Holdings Inc. (the "Company") for the fiscal year ended December 31, 2003 as
filed with the Securities and Exchange Commission on the date hereof (the
"Report"), I, Carol A. Ammon, as Chairman and Chief Executive Officer of the
Company, hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of
her knowledge:

         (1)      The Report fully complies with the requirements of Section
         13(a) or 15(d) of the Securities Exchange Act of 1934; and

         (2)      The information contained in the Report fairly presents, in
         all material respects, the financial condition and results of
         operations of the Company.

/s/ Carol A. Ammon
Name: Carol A. Ammon
Title: Chairman & Chief Executive Officer
Date: March 15, 2004

This certification accompanies this Quarterly Report pursuant to Section 906 of
the Sarbanes-Oxley Act of 2002 and shall not be deemed "filed" by the Company
for purposes of Section 18 of the Securities Exchange Act of 1934, as amended,
or otherwise subject to the liability of that Section.

A signed original of this written statement required by Section 906 has been
provided to, and will be retained by, Endo Pharmaceuticals Holdings Inc. and
furnished to the Securities and Exchange Commission or its staff upon request.