EXHIBIT 1.1







                                6,800,000 SHARES

                          ALGORX PHARMACEUTICALS, INC.

                                  COMMON STOCK

                             UNDERWRITING AGREEMENT

                                                      [__________________], 2005



CREDIT SUISSE FIRST BOSTON LLC
CITIGROUP GLOBAL MARKETS INC.
PIPER JAFFRAY & CO.
LAZARD FRERES & CO. LLC

  As Representatives of the Several Underwriters,
    c/o Credit Suisse First Boston LLC,
             Eleven Madison Avenue,
                New York, N.Y. 10010-3629
    c/o Citigroup Global Markets Inc.
             388 Greenwich Street,
             New York, New York, 10013

Dear Sirs:

      1. Introductory. AlgoRx Pharmaceuticals, Inc, a Delaware corporation
("COMPANY"), proposes to issue and sell 6,800,000 shares ("FIRM SECURITIES") of
its Common Stock, $0.001 par value per share ("SECURITIES"). The Company also
proposes to sell to the Underwriters, at the option of the Underwriters, an
aggregate of not more than 1,020,000 additional shares of its Securities as set
forth below (such 1,020,000 additional shares being hereinafter referred to as
the "OPTIONAL SECURITIES"). The Firm Securities and the Optional Securities are
herein collectively called the "OFFERED SECURITIES". The Company hereby agrees
with the several Underwriters named in Schedule A hereto ("UNDERWRITERS") as
follows:

      2. Representations and Warranties of the Company. (a) The Company
represents and warrants to, and agrees with, the several Underwriters that:

                  (i) A registration statement (No. 333-120757) relating to the
            Offered Securities, including a form of prospectus, has been filed
            with the Securities and Exchange Commission ("COMMISSION") and
            either (A) has been declared effective under the Securities Act of
            1933 ("ACT") and is not proposed to be amended or (B) is proposed to
            be amended by amendment or post-effective amendment. If such
            registration statement (the "INITIAL REGISTRATION STATEMENT") has
            been declared effective, either (A)


                                       1

            an additional registration statement (the "ADDITIONAL REGISTRATION
            STATEMENT") relating to the Offered Securities may have been filed
            with the Commission pursuant to Rule 462(b) ("RULE 462(B)") under
            the Act and, if so filed, has become effective upon filing pursuant
            to such Rule and the Offered Securities all have been duly
            registered under the Act pursuant to the initial registration
            statement and, if applicable, the additional registration statement
            or (B) such an additional registration statement is proposed to be
            filed with the Commission pursuant to Rule 462(b) and will become
            effective upon filing pursuant to such Rule and upon such filing the
            Offered Securities will all have been duly registered under the Act
            pursuant to the initial registration statement and such additional
            registration statement. If the Company does not propose to amend the
            initial registration statement or if an additional registration
            statement has been filed and the Company does not propose to amend
            it, and if any post-effective amendment to either such registration
            statement has been filed with the Commission prior to the execution
            and delivery of this Agreement, the most recent amendment (if any)
            to each such registration statement has been declared effective by
            the Commission or has become effective upon filing pursuant to Rule
            462(c) ("RULE 462(C)") under the Act or, in the case of the
            additional registration statement, Rule 462(b). For purposes of this
            Agreement, "EFFECTIVE TIME" with respect to the initial registration
            statement or, if filed prior to the execution and delivery of this
            Agreement, the additional registration statement means (A) if the
            Company has advised the Representatives that it does not propose to
            amend such registration statement, the date and time as of which
            such registration statement, or the most recent post-effective
            amendment thereto (if any) filed prior to the execution and delivery
            of this Agreement, was declared effective by the Commission or has
            become effective upon filing pursuant to Rule 462(c), or (B) if the
            Company has advised the Representatives that it proposes to file an
            amendment or post-effective amendment to such registration
            statement, the date and time as of which such registration
            statement, as amended by such amendment or post-effective amendment,
            as the case may be, is declared effective by the Commission. If an
            additional registration statement has not been filed prior to the
            execution and delivery of this Agreement but the Company has advised
            the Representatives that it proposes to file one, "EFFECTIVE TIME"
            with respect to such additional registration statement means the
            date and time as of which such registration statement is filed and
            becomes effective pursuant to Rule 462(b). "EFFECTIVE DATE" with
            respect to the initial registration statement or the additional
            registration statement (if any) means the date of the Effective Time
            thereof. The initial registration statement, as amended at its
            Effective Time, including all information contained in the
            additional registration statement (if any) and deemed to be a part
            of the initial registration statement as of the Effective Time of
            the additional registration statement pursuant to the General
            Instructions of the Form on which it is filed and including all
            information (if any) deemed to be a part of the initial registration
            statement as of its Effective Time pursuant to Rule 430A(b) ("RULE
            430A(B)") under the Act, is hereinafter referred to as the "INITIAL
            REGISTRATION STATEMENT". The additional registration statement, as
            amended at its Effective Time, including the contents of the initial
            registration statement incorporated by reference therein and
            including all information (if any) deemed to be a part of the
            additional registration statement as of its Effective Time pursuant
            to Rule 430A(b), is hereinafter referred to as the "ADDITIONAL
            REGISTRATION STATEMENT". The Initial Registration Statement and the
            Additional Registration Statement are hereinafter referred to
            collectively as the "REGISTRATION STATEMENTS" and individually as a
            "REGISTRATION STATEMENT". The form of prospectus relating to the
            Offered Securities, as first filed with the Commission pursuant to
            and in accordance with Rule 424(b) ("RULE 424(B)") under the Act or
            (if no such filing is required) as included in a Registration
            Statement, is hereinafter referred to as the "PROSPECTUS". No
            document has been or will be prepared or distributed in reliance on
            Rule 434 under the Act.


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                  (ii) If the Effective Time of the Initial Registration
            Statement is prior to the execution and delivery of this Agreement:
            (A) on the Effective Date of the Initial Registration Statement, the
            Initial Registration Statement conformed in all material respects to
            the requirements of the Act and the rules and regulations of the
            Commission ("RULES AND REGULATIONS") and did not include any untrue
            statement of a material fact or omit to state any material fact
            required to be stated therein or necessary to make the statements
            therein not misleading, (B) on the Effective Date of the Additional
            Registration Statement (if any), each Registration Statement
            conformed or will conform, in all material respects to the
            requirements of the Act and the Rules and Regulations and did not
            include, or will not include, any untrue statement of a material
            fact and did not omit, or will not omit, to state any material fact
            required to be stated therein or necessary to make the statements
            therein not misleading, and (C) on the date of this Agreement, the
            Initial Registration Statement and, if the Effective Time of the
            Additional Registration Statement is prior to the execution and
            delivery of this Agreement, the Additional Registration Statement
            each conforms, and at the time of filing of the Prospectus pursuant
            to Rule 424(b) or (if no such filing is required) at the Effective
            Date of the Additional Registration Statement in which the
            Prospectus is included, each Registration Statement and the
            Prospectus will conform, in all material respects to the
            requirements of the Act and the Rules and Regulations, and neither
            of such documents includes, or will include, any untrue statement of
            a material fact or omits, or will omit, to state any material fact
            required to be stated therein or necessary to make the statements
            therein, and, in the case of the Prospectus, in light of the
            circumstance under which they were made, not misleading. If the
            Effective Time of the Initial Registration Statement is subsequent
            to the execution and delivery of this Agreement: on the Effective
            Date of the Initial Registration Statement, the Initial Registration
            Statement and the Prospectus will conform in all material respects
            to the requirements of the Act and the Rules and Regulations,
            neither of such documents will include any untrue statement of a
            material fact or will omit to state any material fact required to be
            stated therein or necessary to make the statements therein, and, in
            the case of the Prospectus, in light of the circumstance under which
            they were made, not misleading, and no Additional Registration
            Statement has been or will be filed. The two preceding sentences do
            not apply to statements in or omissions from a Registration
            Statement or the Prospectus based upon written information furnished
            to the Company by any Underwriter through the Representatives
            specifically for use therein, it being understood and agreed that
            the only such information is that described as such in Section 7(b)
            hereof.

                  (iii) The Company has been duly incorporated and is an
            existing corporation in good standing under the laws of the State of
            Delaware, with power and authority (corporate and other) to own its
            properties and conduct its business as described in the Prospectus;
            the Company is duly qualified to do business as a foreign
            corporation in good standing in all other jurisdictions in which its
            ownership or lease of property or the conduct of its business
            requires such qualification except for such jurisdictions where the
            failure to so qualify or to be in good standing would not,
            individually or in the aggregate, have a material adverse effect on
            the condition (financial or other), business, properties or results
            of operations of the Company and its subsidiaries taken as a whole
            ("Material Adverse Effect"); and New Jersey and California are the
            only jurisdictions in which the Company maintains an office or
            leases property.

                  (iv) Each subsidiary of the Company has been duly incorporated
            and is an existing corporation in good standing under the laws of
            the jurisdiction of its incorporation, with power and authority
            (corporate and other) to own its properties and conduct its business
            as described in the Prospectus; and each subsidiary of the Company


                                       3

            is duly qualified to do business as a foreign corporation in good
            standing in all other jurisdictions in which its ownership or lease
            of property or the conduct of its business requires such
            qualification except for such jurisdictions where the failure to so
            qualify or to be in good standing would not, individually or in the
            aggregate, have a Material Adverse Effect; the jurisdictions listed
            on Exhibit A to the opinion to be delivered to the Underwriters by
            Heller Ehrman White & McAuliffe LLP pursuant to Section 6(d)(ii)
            hereof are the only jurisdictions in which the Company's
            subsidiaries maintain an office or lease property; all of the issued
            and outstanding capital stock of each subsidiary of the Company has
            been duly authorized and validly issued and is fully paid and
            nonassessable; and the capital stock of each subsidiary owned by the
            Company, directly or through subsidiaries, is owned free from liens,
            encumbrances and defects.

                  (v) The Offered Securities and all other outstanding shares of
            capital stock of the Company have been duly authorized and conform
            to the description thereof contained in the Prospectus; all
            outstanding shares of capital stock of the Company are, and when the
            Offered Securities have been delivered and paid for in accordance
            with this Agreement on each Closing Date (as defined below), such
            Offered Securities will have been, validly issued, fully paid and
            nonassessable; and the stockholders of the Company have no
            preemptive rights with respect to the Securities.

                  (vi) Except as disclosed in the Prospectus, there are no
            contracts, agreements or understandings between the Company and any
            person that would give rise to a valid claim against the Company or
            any Underwriter for a brokerage commission, finder's fee or other
            like payment in connection with this offering.

                  (vii) Except as disclosed in the Prospectus, there are no
            contracts, agreements or understandings between the Company and any
            person granting such person the right to require the Company to file
            a registration statement under the Act with respect to any
            securities of the Company owned or to be owned by such person or to
            require the Company to include such securities in the securities
            registered pursuant to a Registration Statement or in any securities
            being registered pursuant to any other registration statement filed
            by the Company under the Act.

                  (viii) The Securities have been approved for listing subject
            to notice of issuance on the Nasdaq Stock Market's National Market.

                  (ix) No consent, approval, authorization, or order of, or
            filing with, any governmental agency or body or any court is
            required to be obtained or made by the Company for the consummation
            of the transactions contemplated by this Agreement in connection
            with the sale of the Offered Securities, except (i) such as have
            been obtained and made under the Act and the Securities Exchange Act
            of 1934, as amended, (ii) such as have been filed with and accepted
            by the Delaware Secretary of State, (iii) such consents, approvals
            or filings with the National Association of Securities Dealers, Inc.
            (the "NASD") which have been obtained and made by the Underwriters
            or their counsel in connection with the Offered Securities, (iv)
            such as have been obtained from the Nasdaq National Market and (v)
            such as may be required under state securities laws.

                  (x) The execution, delivery and performance of this Agreement,
            and the consummation of the transactions herein contemplated will
            not result in a breach or violation of any of the terms and
            provisions of, or constitute a default under, any statute,

                                       4

            any rule, regulation or order of any governmental agency or body or
            any court, domestic or foreign, having jurisdiction over the Company
            or any subsidiary of the Company or any of their properties, or any
            agreement or instrument to which the Company or any such subsidiary
            is a party or by which the Company or any such subsidiary is bound
            or to which any of the properties of the Company or any such
            subsidiary is subject, or the charter or by-laws of the Company or
            any such subsidiary.

                  (xi) This Agreement has been duly authorized, executed and
            delivered by the Company.

                  (xii) Except as disclosed in the Prospectus, the Company and
            its subsidiaries have good and marketable title to all real
            properties and all other properties and assets owned by them, in
            each case free from liens, encumbrances and defects that would
            materially affect the value thereof or materially interfere with the
            use made or to be made thereof by them; and except as disclosed in
            the Prospectus, the Company and its subsidiaries hold any leased
            real or personal property under valid and enforceable leases with no
            exceptions that would materially interfere with the use made or to
            be made thereof by them.

                  (xiii) The Company and its subsidiaries possess adequate
            certificates, authorities or permits issued by appropriate
            governmental agencies or bodies necessary to conduct the business
            now operated by them and have not received any notice of proceedings
            relating to the revocation or modification of any such certificate,
            authority or permit that, if determined adversely to the Company or
            any of its subsidiaries, would individually or in the aggregate have
            a Material Adverse Effect.

                  (xiv) No labor dispute with the employees of the Company or
            any subsidiary exists or, to the knowledge of the Company, is
            imminent that would reasonably be expected to have a Material
            Adverse Effect.

                  (xv) (i) The Company and its wholly-owned subsidiaries own, or
            have obtained valid and enforceable licenses for, or other rights to
            use, the inventions, patent applications, patents, trademarks (both
            registered and unregistered), tradenames, service names, copyrights,
            trade secrets and other proprietary information described in the
            Prospectus as being owned or licensed by them or which are necessary
            for the conduct of the Company's business as described in the
            Registration Statement and the Prospectus or necessary in connection
            with commercialization of the product candidates described in the
            Registration Statement and the Prospectus as being under
            development, except where the failure to own, license or have such
            rights would not, individually or in the aggregate, have a Material
            Adverse Effect (collectively, "INTELLECTUAL PROPERTY"); (ii) to the
            Company's knowledge, there are no third parties who have or will be
            able to establish rights to any intellectual property, except for
            the ownership rights of the owners of the intellectual property that
            is licensed to the Company or any of its subsidiaries; (iii) to the
            Company's knowledge, there is no infringement by third parties of
            any intellectual property; (iv) to the Company's knowledge, there is
            no pending or threatened action, suit, proceeding or claim by others
            challenging the rights of the Company or any of its subsidiaries in
            or to any intellectual property, and the Company is unaware of any
            facts which could form a reasonable basis for any such action, suit,
            proceeding or claim; (v) except as described in the Prospectus, to
            the Company's knowledge, there is no pending or threatened action,
            suit, proceeding or claim by others challenging the validity or
            scope of any intellectual property, and the Company is unaware of
            any facts which could form

                                       5

            a reasonable basis for any such action, suit, proceeding or claim;
            (vi) there is no pending against the Company or, to the Company's
            knowledge, threatened action, suit, proceeding or claim by others
            that the Company or any of its subsidiaries infringes, or upon
            commercialization of any product described in the Registration
            Statement or Prospectus as being under development, would infringe,
            or otherwise violates, or, except as would not individually or in
            the aggregate have a Material Adverse Effect, upon commercialization
            of any product described in the Registration Statement or Prospectus
            as being under development, would violate any patent, trademark,
            tradename, service name, copyright, trade secret or other
            proprietary rights of others, and the Company is unaware of any
            facts which could form a reasonable basis for any such action, suit,
            proceeding or claim; (vii) to the Company's knowledge, there is no
            patent or patent application that contains claims that interfere
            with the issued or pending claims of any of the intellectual
            property; and (viii) to the Company's knowledge, there is no prior
            art that may render any patent application owned by the Company or
            any of its subsidiaries of the intellectual property unpatentable.

                  (xvi) Except as disclosed in the Prospectus, neither the
            Company nor any of its subsidiaries is in violation of any statute,
            any rule, regulation, decision or order of any governmental agency
            or body or any court, domestic or foreign, relating to the use,
            disposal or release of hazardous or toxic substances or relating to
            the protection or restoration of the environment or human exposure
            to hazardous or toxic substances (collectively, "ENVIRONMENTAL
            LAWS"), owns or operates any real property contaminated with any
            substance that is subject to any environmental laws, is liable for
            any off-site disposal or contamination pursuant to any environmental
            laws, or is subject to any claim relating to any environmental laws,
            which violation, contamination, liability or claim would
            individually or in the aggregate have Material Adverse Effect; and
            the Company is not aware of any pending investigation which might
            lead to such a claim.

                  (xvii) Except as disclosed in the Prospectus, there are no
            pending actions, suits or proceedings against or, to the knowledge
            of the Company, affecting the Company, any of its subsidiaries or
            any of their respective properties that, if determined adversely to
            the Company or any of its subsidiaries, would individually or in the
            aggregate have a Material Adverse Effect, or would materially and
            adversely affect the ability of the Company to perform its
            obligations under this Agreement, or which are otherwise material in
            the context of the sale of the Offered Securities; and, to the
            Company's knowledge, no such actions, suits or proceedings are
            threatened or, contemplated.

                  (xviii) The financial statements included in each Registration
            Statement and the Prospectus present fairly the financial position
            of the Company and its consolidated subsidiaries as of the dates
            shown and their results of operations and cash flows for the periods
            shown, and, except as otherwise disclosed in the Prospectus, such
            financial statements have been prepared in conformity with the
            generally accepted accounting principles in the United States
            applied on a consistent basis; the schedules included in each
            Registration Statement present fairly the information required to be
            stated therein; and the assumptions used in preparing the pro forma
            financial statements included in each Registration Statement and the
            Prospectus provide a reasonable basis for presenting the significant
            effects directly attributable to the transactions or events
            described therein, the related pro forma adjustments give
            appropriate effect to those assumptions, and the pro forma columns
            therein reflect the proper application of those adjustments to the
            corresponding historical financial statement amounts.


                                       6

                  (xix) Except as disclosed in the Prospectus, since the date of
            the latest audited financial statements included in the Prospectus
            there has been no material adverse change, nor any development or
            event involving a prospective material adverse change, in the
            condition (financial or other), business, properties or results of
            operations of the Company and its subsidiaries taken as a whole,
            and, except as disclosed in or contemplated by the Prospectus, there
            has been no dividend or distribution of any kind declared, paid or
            made by the Company on any class of its capital stock.

                  (xx) The Company after this offering will be subject to the
            reporting requirements of either Section 13 or Section 15(d) of the
            Securities Exchange Act of 1934 and will file reports with the
            Commission on the Electronic Data Gathering, Analysis, and Retrieval
            (EDGAR) system.

                  (xxi) The Company is not and, after giving effect to the
            offering and sale of the Offered Securities and the application of
            the proceeds thereof as described in the Prospectus, will not be an
            "investment company" as defined in the Investment Company Act of
            1940.

                  (xxii) Any statistical and market-related data included in the
            Prospectus are based on or derived from sources that the Company
            reasonably believes to be reliable, and the Company has obtained the
            written consent to the use of such data from such sources to the
            extent required.

                  (xxiii) The clinical, pre-clinical and other studies and tests
            conducted by or on behalf of or sponsored by the Company or any of
            its subsidiaries or in which the Company, any of its subsidiaries or
            its product candidates have participated ("COMPANY STUDIES") that
            are described in the Prospectus or the results of which are referred
            to in the Prospectus were and, if still pending, are being conducted
            in all material respects in accordance with standard medical and
            scientific research procedures; the descriptions in the Prospectus
            of the results of such studies and tests are accurate in all
            material respects, disclose all material aspects of such studies and
            tests, fairly present the data derived from such studies and tests,
            and the Company has no knowledge of any other studies or tests the
            results of which are materially inconsistent with or otherwise
            materially call into question the results described or referred to
            in the Prospectus; the Company and each of its subsidiaries has
            operated and currently is in compliance in all material respects
            with all applicable rules, regulations and policies of the U.S. Food
            and Drug Administration and comparable drug regulatory agencies
            outside of the United States (collectively, the "REGULATORY
            AUTHORITIES"); and except to the extent disclosed in the
            Registration Statement and the Prospectus, neither the Company nor
            any of its subsidiaries has received any notice or other
            correspondence from any Regulatory Authority or any other
            governmental agency requiring the termination, suspension or
            material modification of any Company Studies that are described in
            the Prospectus or the results of which are referred to in the
            Prospectus.

                  (xxiv) Neither the Company nor any of its subsidiaries nor, to
            the knowledge of the Company, any director, officer, agent, employee
            or affiliate of the Company or any of its subsidiaries is aware of
            or has taken any action, directly or indirectly, that would result
            in a violation by such Persons of the FCPA, including, without
            limitation, making use of the mails or any means or instrumentality
            of interstate commerce corruptly in furtherance of an offer,
            payment, promise to pay or authorization of the

                                       7

            payment of any money, or other property, gift, promise to give, or
            authorization of the giving of anything of value to any "foreign
            official" (as such term is defined in the FCPA) or any foreign
            political party or official thereof or any candidate for foreign
            political office, in contravention of the FCPA and the Company, its
            subsidiaries and, to the knowledge of the Company, its affiliates
            have conducted their businesses in compliance with the FCPA and have
            instituted and maintain policies and procedures designed to ensure,
            and which are reasonably expected to continue to ensure, continued
            compliance therewith. "FCPA" means Foreign Corrupt Practices Act of
            1977, as amended, and the rules and regulations thereunder.

                  (xxv) The operations of the Company and its subsidiaries are
            and have been conducted at all times in compliance with applicable
            financial recordkeeping and reporting requirements of the Currency
            and Foreign Transactions Reporting Act of 1970, as amended, the
            money laundering statutes of all jurisdictions, the rules and
            regulations thereunder and any related or similar rules, regulations
            or guidelines, issued, administered or enforced by any governmental
            agency (collectively, the "MONEY LAUNDERING LAWS") and no action,
            suit or proceeding by or before any court or governmental agency,
            authority or body or any arbitrator involving the Company or any of
            its subsidiaries with respect to the Money Laundering Laws is
            pending or, to the best knowledge of the Company, threatened.

                  (xxvi) Neither the Company nor any of its subsidiaries nor, to
            the knowledge of the Company, any director, officer, agent, employee
            or affiliate of the Company or any of its subsidiaries is currently
            subject to any U.S. sanctions administered by the Office of Foreign
            Assets Control of the U.S. Treasury Department ("OFAC"); and the
            Company will not directly or indirectly use the proceeds of the
            offering, or lend, contribute or otherwise make available such
            proceeds to any subsidiary, joint venture partner or other person or
            entity, for the purpose of financing the activities of any person
            currently subject to any U.S. sanctions administered by OFAC.

      3. Purchase, Sale and Delivery of Offered Securities. On the basis of the
representations, warranties and agreements herein contained, but subject to the
terms and conditions herein set forth, the Company agrees to sell to each
Underwriter, and each Underwriter agrees, severally and not jointly, to purchase
from the Company, at a purchase price of $ [______] per share, that number of
Firm Securities set forth opposite the name of such Underwriter in Schedule A
hereto.

      The Company will deliver the Firm Securities to the Representatives for
the accounts of the Underwriters, against payment of the purchase price in
Federal (same day) funds by official bank check or checks or wire transfer to an
account at a bank acceptable to CSFB and Citigroup Global Markets Inc.
("CITIGROUP") drawn to the order of AlgoRx Pharmaceuticals, Inc. at the office
of Ropes & Gray LLP, 45 Rockefeller Plaza, New York, NY 10111, at 10:00 A.M.,
New York time, on [______], 2005, or at such other time not later than seven
full business days thereafter as CSFB and the Company determine, such time being
herein referred to as the "FIRST CLOSING DATE". For purposes of Rule 15c6-1
under the Securities Exchange Act of 1934, the First Closing Date (if later than
the otherwise applicable settlement date) shall be the settlement date for
payment of funds and delivery of securities for all the Offered Securities sold
pursuant to the offering. The certificates for the Firm Securities so to be
delivered will be in definitive form, in such denominations and registered in
such names as CSFB and Citigroup request and will be made available for checking
and packaging at the above office of Ropes & Gray LLP at least 24 hours prior to
the First Closing Date.

      In addition, upon written notice from CSFB and Citigroup given to the
Company from time to time not more than 30 days subsequent to the date of the
Prospectus, the Underwriters may purchase all or less than

                                       8

all of the Optional Securities at the purchase price per Security to be paid for
the Firm Securities. Such Optional Securities shall be purchased from the
Company for the account of each Underwriter in the same proportion as the number
of Firm Securities set forth opposite such Underwriter's name bears to the total
number of Firm Securities (subject to adjustment by CSFB and Citigroup to
eliminate fractions) and may be purchased by the Underwriters only for the
purpose of covering over-allotments made in connection with the sale of the Firm
Securities. No Optional Securities shall be sold or delivered unless the Firm
Securities previously have been, or simultaneously are, sold and delivered. The
right to purchase the Optional Securities or any portion thereof may be
exercised from time to time and to the extent not previously exercised may be
surrendered and terminated at any time upon notice by CSFB and Citigroup to the
Company.

      Each time for the delivery of and payment for the Optional Securities,
being herein referred to as an "OPTIONAL CLOSING DATE", which may be the First
Closing Date (the First Closing Date and each Optional Closing Date, if any,
being sometimes referred to as a "CLOSING DATE"), shall be determined by CSFB
and Citigroup but shall be not later than five full business days after written
notice of election to purchase Optional Securities is given. The Company will
deliver the Optional Securities being purchased on each Optional Closing Date to
the Representatives for the accounts of the several Underwriters, against
payment of the purchase price therefor in Federal (same day) funds by official
bank check or checks or wire transfer to an account at a bank acceptable to CSFB
and Citigroup drawn to the order of AlgoRx Pharmaceuticals, Inc. at the above
office of Ropes & Gray LLP. The certificates for the Optional Securities being
purchased on each Optional Closing Date will be in definitive form, in such
denominations and registered in such names as CSFB and Citigroup request upon
reasonable notice prior to such Optional Closing Date and will be made available
for checking and packaging at the above office of Ropes & Gray LLP at a
reasonable time in advance of such Optional Closing Date.

      4. Offering by Underwriters. It is understood that the several
Underwriters propose to offer the Offered Securities for sale to the public as
set forth in the Prospectus.

      5. Certain Agreements of the Company. The Company agrees with the several
Underwriters that:

            (a) If the Effective Time of the Initial Registration Statement is
      prior to the execution and delivery of this Agreement, the Company will
      file the Prospectus with the Commission pursuant to and in accordance with
      subparagraph (1) (or, if applicable and if consented to by CSFB and
      Citigroup, subparagraph (4)) of Rule 424(b) not later than the earlier of
      (A) the second business day following the execution and delivery of this
      Agreement or (B) the fifteenth business day after the Effective Date of
      the Initial Registration Statement.

      The Company will advise CSFB and Citigroup promptly of any such filing
      pursuant to Rule 424(b). If the Effective Time of the Initial Registration
      Statement is prior to the execution and delivery of this Agreement and an
      additional registration statement is necessary to register a portion of
      the Offered Securities under the Act but the Effective Time thereof has
      not occurred as of such execution and delivery, the Company will file the
      additional registration statement or, if filed, will file a post-effective
      amendment thereto with the Commission pursuant to and in accordance with
      Rule 462(b) on or prior to 10:00 P.M., New York time, on the date of this
      Agreement or, if earlier, on or prior to the time the Prospectus is
      printed and distributed to any Underwriter, or will make such filing at
      such later date as shall have been consented to by CSFB and Citigroup.

            (b) The Company will advise CSFB and Citigroup promptly of any
      proposal to amend or supplement the initial or any additional registration
      statement as filed or the related prospectus or the Initial Registration
      Statement, the Additional Registration Statement (if any) or the
      Prospectus and will not effect such amendment or supplementation without
      CSFB's and Citigroup's consent which will not be unreasonably withheld;
      and the Company will also advise

                                       9

      CSFB and Citigroup promptly of the effectiveness of each Registration
      Statement (if its Effective Time is subsequent to the execution and
      delivery of this Agreement) and of any amendment or supplementation of a
      Registration Statement or the Prospectus and of the institution by the
      Commission of any stop order proceedings in respect of a Registration
      Statement and will use its best efforts to prevent the issuance of any
      such stop order and to obtain as soon as possible its lifting, if issued.

            (c) If, at any time when a prospectus relating to the Offered
      Securities is required to be delivered under the Act in connection with
      sales by any Underwriter or dealer, any event occurs as a result of which
      the Prospectus as then amended or supplemented would include an untrue
      statement of a material fact or omit to state any material fact necessary
      to make the statements therein, in the light of the circumstances under
      which they were made, not misleading, or if it is necessary at any time to
      amend the Prospectus to comply with the Act, the Company will promptly
      notify CSFB and Citigroup of such event and will promptly prepare and file
      with the Commission, at its own expense, an amendment or supplement which
      will correct such statement or omission or an amendment which will effect
      such compliance. Neither CSFB's nor Citigroup's consent to, nor the
      Underwriters' delivery of, any such amendment or supplement shall
      constitute a waiver of any of the conditions set forth in Section 6.

            (d) As soon as practicable, but not later than the Availability Date
      (as defined below), the Company will make generally available to its
      securityholders an earnings statement covering a period of at least 12
      months beginning after the Effective Date of the Initial Registration
      Statement (or, if later, the Effective Date of the Additional Registration
      Statement) which will satisfy the provisions of Section 11(a) of the Act.
      For the purpose of the preceding sentence, "AVAILABILITY DATE" means the
      45th day after the end of the fourth fiscal quarter following the fiscal
      quarter that includes such Effective Date, except that, if such fourth
      fiscal quarter is the last quarter of the Company's fiscal year,
      "AVAILABILITY DATE" means the 90th day after the end of such fourth fiscal
      quarter.

            (e) The Company will furnish to the Representatives copies of each
      Registration Statement (5 of which will be signed and will include all
      exhibits), each related preliminary prospectus, and, so long as a
      prospectus relating to the Offered Securities is required to be delivered
      under the Act in connection with sales by any Underwriter or dealer, the
      Prospectus and all amendments and supplements to such documents, in each
      case in such quantities as CSFB and Citigroup request. The Prospectus
      shall be so furnished on or prior to 3:00 P.M., New York time, on the
      business day following the later of the execution and delivery of this
      Agreement or the Effective Time of the Initial Registration Statement. All
      other such documents shall be so furnished as soon as available. The
      Company will pay the expenses of printing and distributing to the
      Underwriters all such documents.

            (f) The Company will arrange for the qualification of the Offered
      Securities for sale under the laws of such jurisdictions as CSFB and
      Citigroup designates and will continue such qualifications in effect so
      long as required for the distribution, provided, that in connection
      therewith the Company shall not be required to qualify as a foreign
      corporation or to file a general consent to service of process in any
      jurisdiction or to subject itself to taxation for doing business in any
      jurisdiction where it is not now so subject.

            (g) For the period specified below (the "LOCK-UP PERIOD"), the
      Company will not offer, sell, contract to sell, pledge or otherwise
      dispose of, directly or indirectly, or file with the Commission a
      registration statement under the Act relating to, any additional shares of
      its Securities or securities convertible into or exchangeable or
      exercisable for any shares of its

                                       10

      Securities, or publicly disclose the intention to make any such offer,
      sale, pledge, disposition or filing, without the prior written consent of
      CSFB and Citigroup, except (i) issuances of Securities pursuant to the
      conversion or exchange of convertible or exchangeable securities or the
      exercise of warrants, options or other rights to acquire securities , in
      each case outstanding or issued under equity-based compensation plans
      existing on the date hereof (provided, in each case, the recipients have
      entered into lock-up agreements substantially in the form of Exhibit A
      hereto prior to the issuance of such securities), (ii) grants of
      stock-based awards to employees, directors or consultants pursuant to the
      terms of a plan in effect on the date hereof, or (iii) Form S-8 filings
      with respect to any plans in effect on the date hereof. The initial
      Lock-Up Period will commence on the date hereof and will continue and
      include the date 180 days after the date hereof or such earlier date that
      CSFB and Citigroup consent to in writing; provided, however, that if (1)
      during the last 17 days of the initial Lock-Up Period, the Company
      releases earnings results or material news or a material event relating to
      the Company occurs or (2) prior to the expiration of the initial Lock-Up
      period, the Company announces that it will release earnings results during
      the 16-day period beginning on the last day of the initial Lock-Up Period,
      then in each case the Lock-Up Period will be extended until the expiration
      of the 18-day period beginning on the date of release of the earnings
      results or the occurrence of the material news or material event, as
      applicable, unless CSFB and Citigroup waive, in writing, such extension.
      The Company will provide CSFB and Citigroup with notice of any
      announcement described in clause (2) of the preceding sentence that gives
      rise to an extension of the Lock-up Period.

            (h) The Company agrees with the several Underwriters that the
      Company will pay all expenses incident to the performance of the
      obligations of the Company under this Agreement, for any filing fees and
      other expenses (including fees and disbursements of counsel) in connection
      with qualification of the Offered Securities for sale under the laws of
      such jurisdictions as CSFB and Citigroup designates and the printing of
      memoranda relating thereto for the filing fee incident to the review by
      the National Association of Securities Dealers, Inc. (the "NASD") of the
      Offered Securities, for any travel expenses of the Company's officers and
      employees and any other expenses of the Company in connection with
      attending or hosting meetings with prospective purchasers of the Offered
      Securities, including the cost of any aircraft chartered by or on behalf
      of the Company in connection with attending or hosting such meetings and
      for expenses incurred in distributing preliminary prospectuses and the
      Prospectus (including any amendments and supplements thereto) to the
      Underwriters.

            (i) The Company will comply with all applicable securities and other
      applicable laws, rules and regulations, including, without limitation, the
      Sarbanes Oxley Act, and to use its best efforts to cause the Company's
      directors and officers, in their capacities as such, to comply with such
      laws, rules and regulations, including, without limitation, the provisions
      of the Sarbanes Oxley Act.

      6. Conditions of the Obligations of the Underwriters. The obligations of
the several Underwriters to purchase and pay for the Firm Securities on the
First Closing Date and the Optional Securities to be purchased on each Optional
Closing Date will be subject to the accuracy of the representations and
warranties on the part of the Company to the accuracy of the statements of
Company officers made pursuant to the provisions hereof, to the performance by
the Company of its obligations hereunder and to the following additional
conditions precedent:

            (a) The Representatives shall have received a letter, dated the date
      of delivery thereof (which, if the Effective Time of the Initial
      Registration Statement is prior to the execution and delivery of this
      Agreement, shall be on or prior to the date of this Agreement or, if the

                                       11

      Effective Time of the Initial Registration Statement is subsequent to the
      execution and delivery of this Agreement, shall be prior to the filing of
      the amendment or post-effective amendment to the registration statement to
      be filed shortly prior to such Effective Time), of Ernst & Young LLP
      confirming that they are independent public accountants within the meaning
      of the Act and the applicable published Rules and Regulations thereunder
      and stating to the effect that:

                  (i) in their opinion the financial statements and schedules
            examined by them and included in the Registration Statements comply
            as to form in all material respects with the applicable accounting
            requirements of the Act and the related published Rules and
            Regulations;

                  (ii) they have performed the procedures specified by the
            American Institute of Certified Public Accountants for a review of
            interim financial information as described in Statement of Auditing
            Standards No. 100, Interim Financial Information, on the unaudited
            financial statements included in the Registration Statements;

                  (iii) on the basis of the review referred to in clause (ii)
            above, a reading of the latest available interim financial
            statements of the Company, inquiries of officials of the Company who
            have responsibility for financial and accounting matters and other
            specified procedures, nothing came to their attention that caused
            them to believe that:

                        (A) the unaudited financial statements included in the
                  Registration Statements do not comply as to form in all
                  material respects with the applicable accounting requirements
                  of the Act and the related published Rules and Regulations or
                  any material modifications should be made to such unaudited
                  financial statements for them to be in conformity with
                  generally accepted accounting principles;

                        (B) at the date of the latest available balance sheet
                  read by such accountants, or at a subsequent specified date
                  not more than three business days prior to the date of this
                  Agreement, there was any change in the capital stock or any
                  increase in short-term indebtedness or long-term debt of the
                  Company and its consolidated subsidiaries or, at the date of
                  the latest available balance sheet read by such accountants,
                  there was any decrease in consolidated net assets, as compared
                  with amounts shown on the latest balance sheet included in the
                  Prospectus; or

                        (C) for the period from the closing date of the latest
                  income statement included in the Prospectus to the closing
                  date of the latest available income statement read by such
                  accountants there were any decreases, as compared with the
                  corresponding period of the previous year, in consolidated net
                  sales or net operating income in the total or per share
                  amounts of consolidated net income;

            except in all cases set forth in clauses (B) and (C) above for
            changes, increases or decreases which the Prospectus discloses have
            occurred or may occur or which are described in such letter; and

                  (iv) they have compared specified dollar amounts (or
            percentages derived from such dollar amounts) and other financial
            information contained in the Registration Statements (in each case
            to the extent that such dollar amounts, percentages and other
            financial information are derived from the general accounting
            records of the Company and

                                       12

            its subsidiaries subject to the internal controls of the Company's
            accounting system or are derived directly from such records by
            analysis or computation) with the results obtained from inquiries, a
            reading of such general accounting records and other procedures
            specified in such letter and have found such dollar amounts,
            percentages and other financial information to be in agreement with
            such results, except as otherwise specified in such letter.

      For purposes of this subsection, (i) if the Effective Time of the Initial
      Registration Statement is subsequent to the execution and delivery of this
      Agreement, "REGISTRATION STATEMENTS" shall mean the initial registration
      statement as proposed to be amended by the amendment or post-effective
      amendment to be filed shortly prior to its Effective Time, (ii) if the
      Effective Time of the Initial Registration Statement is prior to the
      execution and delivery of this Agreement but the Effective Time of the
      Additional Registration Statement is subsequent to such execution and
      delivery, "REGISTRATION STATEMENTS" shall mean the Initial Registration
      Statement and the additional registration statement as proposed to be
      filed or as proposed to be amended by the post-effective amendment to be
      filed shortly prior to its Effective Time, and (iii) "PROSPECTUS" shall
      mean the prospectus included in the Registration Statements.

            (b) If the Effective Time of the Initial Registration Statement is
      not prior to the execution and delivery of this Agreement, such Effective
      Time shall have occurred not later than 10:00 P.M., New York time, on the
      date of this Agreement or such later date as shall have been consented to
      by CSFB and Citigroup. If the Effective Time of the Additional
      Registration Statement (if any) is not prior to the execution and delivery
      of this Agreement, such Effective Time shall have occurred not later than
      10:00 P.M., New York time, on the date of this Agreement or, if earlier,
      the time the Prospectus is printed and distributed to any Underwriter, or
      shall have occurred at such later date as shall have been consented to by
      CSFB and Citigroup. If the Effective Time of the Initial Registration
      Statement is prior to the execution and delivery of this Agreement, the
      Prospectus shall have been filed with the Commission in accordance with
      the Rules and Regulations and Section 5(a) of this Agreement. Prior to
      such Closing Date, no stop order suspending the effectiveness of a
      Registration Statement shall have been issued and no proceedings for that
      purpose shall have been instituted, to the knowledge of the Company or the
      Representatives, shall be contemplated by the Commission.

            (c) Subsequent to the execution and delivery of this Agreement,
      there shall not have occurred (i) any change, or any development or event
      involving a prospective change, in the condition (financial or other),
      business, properties or results of operations of the Company and its
      subsidiaries taken as one enterprise which, in the judgment of the
      Representatives, is material and adverse and makes it impractical or
      inadvisable to proceed with completion of the public offering or the sale
      of and payment for the Offered Securities; (ii) any downgrading in the
      rating of any debt securities of the Company by any "nationally recognized
      statistical rating organization" (as defined for purposes of Rule 436(g)
      under the Act), or any public announcement that any such organization has
      under surveillance or review its rating of any debt securities of the
      Company (other than an announcement with positive implications of a
      possible upgrading, and no implication of a possible downgrading, of such
      rating); (iii) any change in U.S. or international financial, political or
      economic conditions or currency exchange rates or exchange controls as
      would, in the judgment of the Representatives, be likely to prejudice
      materially the success of the proposed issue, sale or distribution of the
      Offered Securities, whether in the primary market or in respect of
      dealings in the secondary market; (iv) any material suspension or material
      limitation of trading in securities generally on the New York Stock
      Exchange or any setting of minimum prices for trading on such exchange;
      (v) or any suspension of trading of any securities of the Company on any
      exchange or in the over-the-counter market; (vi) any banking moratorium
      declared by U.S. Federal or New York authorities; (vii) any major
      disruption of settlements of securities or clearance services in the
      United States or (viii) any attack on, outbreak or escalation of
      hostilities or act of terrorism involving the United States, any
      declaration of war by Congress or any other national or international
      calamity or emergency if, in the judgment of the

                                       13

      Representatives, the effect of any such attack, outbreak, escalation, act,
      declaration, calamity or emergency makes it impractical or inadvisable to
      proceed with completion of the public offering or the sale of and payment
      for the Offered Securities.

            (d) The Representatives shall have received an opinion, dated such
      Closing Date, of Heller Ehrman White & McAuliffe LLP, counsel for the
      Company, in the form set forth in Exhibit 6D.

            (e) The Representatives shall have received an opinion, dated such
      Closing Date, from Hogan & Hartson L.L.P., as special regulatory counsel
      for the Company in the U.S. Food and Drug Administration ("FDA") and the
      U.S. Centers for Medicare and Medicaid Services ("CMS") areas only, in the
      form set forth in Exhibit 6E.

            (f) The Representatives shall have received an opinion, dated such
      Closing Date, from Davidson, Davidson & Kappel, LLC, intellectual property
      counsel for the Company in the form set forth in Exhibit 6F.

            (g) The Representatives shall have received from Ropes & Gray LLP,
      counsel for the Underwriters, such opinion or opinions, dated such Closing
      Date, with respect to the incorporation of the Company, the validity of
      the Offered Securities delivered on such Closing Date, the Registration
      Statements, the Prospectus and other related matters as the
      Representatives may require, and the Company shall have furnished to such
      counsel such documents as they request for the purpose of enabling them to
      pass upon such matters.

            (h) The Representatives shall have received a certificate, dated
      such Closing Date, of the President or any Vice President and a principal
      financial or accounting officer of the Company in which such officers, to
      the best of their knowledge after reasonable investigation, shall state
      that: the representations and warranties of the Company in this Agreement
      are true and correct; the Company has complied with all agreements and
      satisfied all conditions on its part to be performed or satisfied
      hereunder at or prior to such Closing Date; no stop order suspending the
      effectiveness of any Registration Statement has been issued and no
      proceedings for that purpose have been instituted or are contemplated by
      the Commission; the Additional Registration Statement (if any) satisfying
      the requirements of subparagraphs (1) and (3) of Rule 462(b) was filed
      pursuant to Rule 462(b), including payment of the applicable filing fee in
      accordance with Rule 111(a) or (b) under the Act, prior to the time the
      Prospectus was printed and distributed to any Underwriter; and, subsequent
      to the date of the most recent financial statements in the Prospectus,
      there has been no material adverse change, nor any development or event
      involving a prospective material adverse change, in the condition
      (financial or other), business, properties or results of operations of the
      Company and its subsidiaries taken as a whole except as set forth in the
      Prospectus or as described in such certificate.

            (i) The Representatives shall have received a letter, dated such
      Closing Date, of Ernst & Young LLP which meets the requirements of
      subsection (a) of this Section, except that the specified date referred to
      in such subsection will be a date not more than three days prior to such
      Closing Date for the purposes of this subsection.

            (j) On or prior to the date of this Agreement, the Representatives
      shall have received a lockup letter Company in the form attached hereto as
      Exhibit A from each executive officer and director and from holders of at
      least 99% of all shares of the Common Stock of the Company treating all
      outstanding equity securities of the Company on a fully-diluted basis.

The Company will furnish the Representatives with such conformed copies of such
opinions, certificates, letters and documents as the Representatives reasonably
requests. CSFB and Citigroup may in their sole

                                       14

discretion waive on behalf of the Underwriters compliance with any conditions to
the obligations of the Underwriters hereunder, whether in respect of an Optional
Closing Date or otherwise.

      7. Indemnification and Contribution. (a) The Company will indemnify and
hold harmless each Underwriter, its partners, members, directors officers and
its affiliates and each person, if any who controls such Underwriter within the
meaning of Section 15 of the Act, against any losses, claims, damages or
liabilities, joint or several, to which such Underwriter may become subject,
under the Act or otherwise, insofar as such losses, claims, damages or
liabilities (or actions in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained in
any Registration Statement, the Prospectus, or any amendment or supplement
thereto, or any related preliminary prospectus, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
and will reimburse each Underwriter for any legal or other expenses reasonably
incurred by such Underwriter in connection with investigating or defending any
such loss, claim, damage, liability or action as such expenses are incurred;
provided, however, that the Company will not be liable in any such case to the
extent that any such loss, claim, damage or liability arises out of or is based
upon an untrue statement or alleged untrue statement in or omission or alleged
omission from any of such documents in reliance upon and in conformity with
written information furnished to the Company by any Underwriter through the
Representatives specifically for use therein, it being understood and agreed
that the only such information furnished by any Underwriter consists of the
information described as such in subsection (b) below; provided further, that
with respect to any untrue statement or omission of material fact made in any
preliminary prospectus, the indemnity agreement contained in this Section 8(a)
shall not inure to the benefit of any Underwriter from whom the person asserting
any such loss, claim, damage or liability purchased the securities concerned, to
the extent that any such loss, claim, damage or liability of such Underwriter
occurs under the circumstance where it shall have been determined by a court of
competent jurisdiction by final and nonappealable judgment that (v) the Company
had previously furnished copies of the Prospectus to the Representatives, (w)
delivery of the Prospectus was required by the Act to be made to such person,
(x) the untrue statement or omission of a material fact contained in the
Preliminary Prospectus was corrected in the Prospectus, (y) there was not sent
or given to such person, at or prior to the written confirmation of the sale of
such securities to such person, a copy of the Prospectus and (z) such failure to
send or give to such person, at or prior to the written confirmation of the sale
of such securities to such person, a copy of the Prospectus caused such person
any loss, claim, damage or liability.

      (b) Each Underwriter will severally and not jointly indemnify and hold
harmless the Company, its directors and officers and each person, if any, who
controls the Company within the meaning of Section 15 of the Act against any
losses, claims, damages or liabilities to which the Company may become subject,
under the Act or otherwise, insofar as such losses, claims, damages or
liabilities (or actions in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained in
any Registration Statement, the Prospectus, or any amendment or supplement
thereto, or any related preliminary prospectus, or arise out of or are based
upon the omission or the alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein not
misleading, in each case to the extent, but only to the extent, that such untrue
statement or alleged untrue statement or omission or alleged omission was made
in reliance upon and in conformity with written information furnished to the
Company by such Underwriter through the Representatives specifically for use
therein, and will reimburse any legal or other expenses reasonably incurred by
the Company in connection with investigating or defending any such loss, claim,
damage, liability or action as such expenses are incurred, it being understood
and agreed that the only such information furnished by any Underwriter consists
of the following information in the Prospectus furnished on behalf of each
Underwriter: the concession and reallowance figures appearing in the [fifth]
paragraph under the caption "Underwriting" and the information contained in the
fourteenth, fifteenth and sixteenth paragraphs under the caption "Underwriting."

      (c) Promptly after receipt by an indemnified party under this Section of
notice of the commencement of any action, such indemnified party will, if a
claim in respect thereof is to be made against an indemnifying party under
subsection (a) or (b) above, notify the indemnifying party of the commencement
thereof; but the failure to notify the indemnifying party shall not relieve it
from any liability that it may have under subsection (a) or (b) above except to
the extent that it has been materially prejudiced (through the forfeiture of
substantive rights or defenses) by such failure; and provided further that the
failure to notify the indemnifying party shall not relieve it from any liability
that it may have to an indemnified party otherwise than under subsection (a) or
(b) above. In case any such action is brought against any indemnified party and
it notifies an indemnifying party of the commencement thereof, the indemnifying
party will be entitled to participate therein and, to the extent that it may
wish, jointly with any other indemnifying party similarly notified, to assume
the defense thereof, with counsel satisfactory to such indemnified party (who
shall not, except with the consent of the indemnified party, be counsel to the
indemnifying party), and after notice from the indemnifying party to such
indemnified party of its election so to assume the defense thereof, the

                                       15

indemnifying party will not be liable to such indemnified party under this
Section for any legal or other expenses subsequently incurred by such
indemnified party in connection with the defense thereof other than reasonable
costs of investigation. No indemnifying party shall, without the prior written
consent of the indemnified party, effect any settlement of any pending or
threatened action in respect of which any indemnified party is or could have
been a party and indemnity could have been sought hereunder by such indemnified
party unless such settlement (i) includes an unconditional release of such
indemnified party from all liability on any claims that are the subject matter
of such action and (ii) does not include a statement as to, or an admission of,
fault, culpability or a failure to act by or on behalf of an indemnified party.

      (d) If the indemnification provided for in this Section is unavailable or
insufficient to hold harmless an indemnified party under subsection (a) or (b)
above, then each indemnifying party shall contribute to the amount paid or
payable by such indemnified party as a result of the losses, claims, damages or
liabilities referred to in subsection (a) or (b) above (i) in such proportion as
is appropriate to reflect the relative benefits received by the Company on the
one hand and the Underwriters on the other from the offering of the Securities
or (ii) if the allocation provided by clause (i) above is not permitted by
applicable law, in such proportion as is appropriate to reflect not only the
relative benefits referred to in clause (i) above but also the relative fault of
the Company on the one hand and the Underwriters on the other in connection with
the statements or omissions which resulted in such losses, claims, damages or
liabilities as well as any other relevant equitable considerations. The relative
benefits received by the Company on the one hand and the Underwriters on the
other shall be deemed to be in the same proportion as the total net proceeds
from the offering (before deducting expenses) received by the Company bear to
the total underwriting discounts and commissions received by the Underwriters.
The relative fault shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission or alleged omission to state a material fact relates to information
supplied by the Company or the Underwriters and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
untrue statement or omission. The amount paid by an indemnified party as a
result of the losses, claims, damages or liabilities referred to in the first
sentence of this subsection (d) shall be deemed to include any legal or other
expenses reasonably incurred by such indemnified party in connection with
investigating or defending any action or claim which is the subject of this
subsection (d). Notwithstanding the provisions of this subsection (d), no
Underwriter shall be required to contribute any amount in excess of the amount
by which the total price at which the Securities underwritten by it and
distributed to the public were offered to the public exceeds the amount of any
damages which such Underwriter has otherwise been required to pay by reason of
such untrue or alleged untrue statement or omission or alleged omission. No
person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Act) shall be entitled to contribution from any person who was not
guilty of such fraudulent misrepresentation. The Underwriters' obligations in
this subsection (d) to contribute are several in proportion to their respective
underwriting obligations and not joint.

      (e) The obligations of the Company under this Section shall be in addition
to any liability which the Company may otherwise have and shall extend, upon the
same terms and conditions, to each person, if any, who controls any Underwriter
within the meaning of the Act; and the obligations of the Underwriters under
this Section shall be in addition to any liability which the respective
Underwriters may otherwise have and shall extend, upon the same terms and
conditions, to each director of the Company, to each officer of the Company who
has signed a Registration Statement and to each person, if any, who controls the
Company within the meaning of the Act.

      8. Default of Underwriters. If any Underwriter or Underwriters default in
their obligations to purchase Offered Securities hereunder on either the First
or any Optional Closing Date and the aggregate number of shares of Offered
Securities that such defaulting Underwriter or Underwriters agreed but failed to
purchase does not exceed 10% of the total number of shares of Offered Securities
that the Underwriters are obligated to purchase on such Closing Date, CSFB and
Citigroup may make arrangements satisfactory to the Company for the purchase of
such Offered Securities by other persons, including any of the Underwriters, but
if no such arrangements are made by such Closing Date, the non-defaulting
Underwriters shall be obligated

                                       16

severally, in proportion to their respective commitments hereunder, to purchase
the Offered Securities that such defaulting Underwriters agreed but failed to
purchase on such Closing Date. If any Underwriter or Underwriters so default and
the aggregate number of shares of Offered Securities with respect to which such
default or defaults occur exceeds 10% of the total number of shares of Offered
Securities that the Underwriters are obligated to purchase on such Closing Date
and arrangements satisfactory to CSFB, Citigroup and the Company for the
purchase of such Offered Securities by other persons are not made within 36
hours after such default, this Agreement will terminate without liability on the
part of any non-defaulting Underwriter or the Company, except as provided in
Section 9 (provided that if such default occurs with respect to Optional
Securities after the First Closing Date, this Agreement will not terminate as to
the Firm Securities or any Optional Securities purchased prior to such
termination). As used in this Agreement, the term "Underwriter" includes any
person substituted for an Underwriter under this Section. Nothing herein will
relieve a defaulting Underwriter from liability for its default.

      9. Survival of Certain Representations and Obligations. The respective
indemnities, agreements, representations, warranties and other statements of the
Company or its officers and of the several Underwriters set forth in or made
pursuant to this Agreement will remain in full force and effect, regardless of
any investigation, or statement as to the results thereof, made by or on behalf
of any Underwriter, the Company or any of their respective representatives,
officers or directors or any controlling person, and will survive delivery of
and payment for the Offered Securities. If this Agreement is terminated pursuant
to Section 8 or if for any reason the purchase of the Offered Securities by the
Underwriters is not consummated, the Company shall remain responsible for the
expenses to be paid or reimbursed by it pursuant to Section 5 and the respective
obligations of the Company and the Underwriters pursuant to Section 7 shall
remain in effect, and if any Offered Securities have been purchased hereunder
the representations and warranties in Section 2 and all obligations under
Section 5 shall also remain in effect. If the purchase of the Offered Securities
by the Underwriters is not consummated for any reason other than solely because
of the termination of this Agreement pursuant to Section 8 or the occurrence of
any event specified in clauses (iii), (iv), (vi), (vii) or (viii) of Section
6(c), the Company will reimburse the Underwriters for all out-of-pocket expenses
(including fees and disbursements of counsel) reasonably incurred by them in
connection with the offering of the Offered Securities.

      10. Notices. All communications hereunder will be in writing and, if sent
to the Underwriters, will be mailed, delivered or faxed and confirmed to the
Representatives, c/o Credit Suisse First Boston LLC, Eleven Madison Avenue, New
York, N.Y. 10010-3629, Attention: IBD-Legal (fax: 212-325-4296) and Citigroup
Global Markets Inc., 388 Greenwich Street, New York, New York, 10013, Attention:
General Counsel (fax: 212-816-7912), or, if sent to the Company, will be mailed,
delivered or faxed and confirmed to it at 500 Plaza Drive, 2nd Floor, Secaucus,
New Jersey 07094-3619, Attention: Chief Financial Officer (fax: 201-325-6905);
provided, however, that any notice to an Underwriter pursuant to Section 7 will
be mailed, delivered or faxed and confirmed to such Underwriter.

      11. Successors. This Agreement will inure to the benefit of and be binding
upon the parties hereto and their respective personal representatives and
successors and the officers and directors and controlling persons referred to in
Section 7, and no other person will have any right or obligation hereunder.

      12. Representation. The Representatives will act for the several
Underwriters in connection with the transactions contemplated by this Agreement,
and any action under this Agreement taken by the Representatives jointly or by
CSFB and Citigroup will be binding upon all the Underwriters.

      13. Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, but all such
counterparts shall together constitute one and the same Agreement.

      14. APPLICABLE LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN
ACCORDANCE WITH,

                                       17

THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF
LAWS.

      The Company hereby submits to the non-exclusive jurisdiction of the
Federal and state courts in the Borough of Manhattan in The City of New York in
any suit or proceeding arising out of or relating to this Agreement or the
transactions contemplated hereby.




                                       18


      If the foregoing is in accordance with the Representatives'
understanding of our agreement, kindly sign and return to the Company one of the
counterparts hereof, whereupon it will become a binding agreement among the
Company and the several Underwriters in accordance with its terms.

                                    Very truly yours,



                                    ALGORX PHARMACEUTICALS, INC.



                                    By:.........................................

                                    Name:

                                    Title:

The foregoing Underwriting Agreement is hereby confirmed and accepted
  as of the date first above written.

CREDIT SUISSE FIRST BOSTON LLC
CITIGROUP GLOBAL MARKETS INC.
PIPER JAFFRAY & CO.
LAZARD FRERES & CO. LLC

    Acting on behalf of themselves and as the Representatives of the
    several Underwriters.


    By  CREDIT SUISSE FIRST BOSTON LLC



      By.....................................................

        Name:

        Title:


    By  CITIGROUP GLOBAL MARKETS INC.



      By.....................................................

        Name:

        Title:




                    Signature Page to Underwriting Agreement

                                   SCHEDULE A





                                                           NUMBER OF
                                                        FIRM SECURITIES
            UNDERWRITER                                 TO BE PURCHASED
            -----------                                 ---------------
                                                     
Credit Suisse First Boston LLC......................    [______________]
Citigroup Global Markets Inc........................    [______________]
Piper Jaffray & Co..................................    [______________]
Lazard Freres & Co. LLC.............................    [______________]

                  Total.............................         [6,800,000]
                                                              =========


                                    EXHIBIT A

                                 Form of Lock Up

                                                 _________________________, 2004

AlgoRx Pharmaceuticals, Inc.
500 Plaza Drive, 2nd Floor
Secaucus, NJ  07094

Credit Suisse First Boston LLC
Citigroup Global Markets
Piper Jaffray & Co.
Lazard Freres & Co. LLC

c/o Credit Suisse First Boston LLC
    Eleven Madison Avenue
    New York, NY   10010-3629

Dear Sirs:

      As an inducement to the Underwriters to execute the Underwriting
Agreement, pursuant to which an offering (the "OFFERING") will be made that is
intended to result in the establishment of a public market for the Common Stock
(the "SECURITIES") of AlgoRx Pharmaceuticals, Inc., a Delaware corporation, and
any successor (by merger or otherwise) thereto, (the "Company"), the undersigned
hereby agrees that during the period specified in the following two paragraphs
(the "LOCK-UP PERIOD"), the undersigned will not offer, sell, contract to sell,
pledge or otherwise dispose of, directly or indirectly, any shares of Securities
or securities convertible into or exchangeable or exercisable for any shares of
Securities, enter into a transaction which would have the same effect, or enter
into any swap, hedge or other arrangement that transfers, in whole or in part,
any of the economic consequences of ownership of the Securities, whether any
such aforementioned transaction is to be settled by delivery of the Securities
or such other securities, in cash or otherwise, or publicly disclose the
intention to make any such offer, sale, pledge or disposition, or to enter into
any such transaction, swap, hedge or other arrangement, without, in each case,
the prior written consent of Credit Suisse First Boston LLC ("CSFB") and
Citigroup Global Markets ("CITIGROUP"). In addition, the undersigned agrees
that, without the prior written consent of CSFB and Citigroup, it will not,
during the Lock-Up Period, make any demand for or exercise any right with
respect to, the registration of any Securities or any security convertible into
or exercisable or exchangeable for the Securities.

      The initial Lock-Up Period will commence on the later of (x) the date of
this Lock-Up Agreement or (y) the date of the initial filing with the Securities
and Exchange Commission of the Registration Statement on Form S-1 for the
Offering and continue and include the date 180 days after the public offering
date set forth on the final prospectus used to sell the Securities (the "PUBLIC
OFFERING DATE") pursuant to the Underwriting Agreement, to which you are or
expect to become parties; provided, however, that if (1) during the last 17 days
of the initial Lock-Up Period, the Company releases earnings results or material
news or a material event relating to the Company

occurs or (2) prior to the expiration of the initial Lock-Up Period, the Company
announces that it will release earnings results during the 16-day period
beginning on the last day of the initial Lock-Up Period, then in each case the
Lock-Up Period will be extended until the expiration of the 18-day period
beginning on the date of release of the earnings results or the occurrence of
the material news or material event, as applicable, unless CSFB and Citigroup
waives, in writing, such extension.

      The undersigned hereby acknowledges and agrees that written notice of any
extension of the Lock-Up Period pursuant to the previous paragraph will be
delivered by CSFB and Citigroup to the Company (in accordance with Section 10 of
the Underwriting Agreement) and that any such notice properly delivered will be
deemed to have been given to, and received by, the undersigned. The undersigned
further agrees that, prior to engaging in any transaction or taking any other
action that is subject to the restrictions of this Lock-Up Agreement during the
period from the date of this Lock-Up Agreement to an including the 34th day
following the expiration of the initial Lock-Up Period, it will give notice
thereof to the Company and will not consummate such transaction or take any such
action unless it has received written confirmation from the Company that the
Lock-Up Period (as may have been extended pursuant to the previous paragraph)
has expired.

      Any Securities received upon exercise of options granted to the
undersigned will also be subject to this Agreement. The foregoing restrictions
shall not apply to any transfer of Securities (a) to any underwriters in the
Offering pursuant to the underwriting agreement for the Offering; (b) as a bona
fide gift or gifts; (c) to any trust for the benefit of the undersigned or the
undersigned's family; (d) by will or intestacy to the undersigned's legal
representative, heir or legatee; (e) if the undersigned is a partnership,
corporation, limited liability company or similar entity, (1) to another
corporation, partnership or other business entity if the transferee and the
undersigned are "affiliates" as defined in Rule 405 promulgated under the
Securities Act of 1933, as amended, or (2) as a distribution to partners,
stockholders or members of the undersigned; or (f) acquired in the public market
on or after the date of the final prospectus filed by the Company with the
Securities and Exchange Commission in connection with the Offering, provided
that in the case of any transfer pursuant to any of clauses (b) through (f) each
donee, transferee or distributee shall execute and deliver to CSFB a duplicate
form of this letter and no filing by any party (donor, transferor, distributor,
donee, transferee or distributee) under the Securities Exchange Act of 1934, as
amended, shall be required or shall be voluntarily made in connection with such
donation, transfer or distribution (other than a filing on a Form 5 made after
the expiration of the Lock-Up Period).

      In furtherance of the foregoing, the Company and its transfer agent and
registrar are hereby authorized to decline to make any transfer of shares of
Securities if such transfer would constitute a violation or breach of this
Agreement.

      This Agreement shall be binding on the undersigned and the successors,
heirs, personal representatives and assigns of the undersigned. This Agreement
shall lapse and become null and void if the Public Offering Date shall not have
occurred on or before May 31, 2005 (or earlier if the Company or both CSFB and
Citigroup terminates the Offering by written notice to the other). THIS
AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF
THE STATE OF NEW YORK.



                                    Very truly yours,


                                    --------------------------------------------

                                    [SIGNATURE OF STOCKHOLDER]

                                    Print name:
                                               ---------------------------------

If stockholder is an institution,   Title:
trust or other entity, please             --------------------------------------
print name of such institution,
trust or entity and your title:     Entity name:
                                                --------------------------------

If Securities are jointly held,     Joint
joint holder should also sign       stockholder:
this letter:                                    --------------------------------
                                                [SIGNATURE OF JOINT STOCKHOLDER]