EXHIBIT 12.1

                         REGENERON PHARMACEUTICALS, INC.
           COMPUTATION OF RATIO OF EARNINGS TO COMBINED FIXED CHARGES
                             (Dollars in thousands)



                                                                      Years ended December 31,
                                                   -------------------------------------------------------------
                                                     2000         2001         2002         2003         2004
                                                   ---------    ---------    ---------    ---------    ---------
                                                                                        
Earnings:
    Income (loss) from continuing operations
       before income (loss) from equity investee   ($ 17,077)   ($ 75,178)   ($124,350)   ($107,395)   $  41,565
    Fixed charges                                      1,309        3,888       13,685       14,108       14,060
    Amortization of capitalized interest                  --           --           --           33           78
    Interest capitalized                                  --           --         (222)        (276)          --
                                                   ---------    ---------    ---------    ---------    ---------
Adjusted earnings                                  ($ 15,768)   ($ 71,290)   ($110,887)   ($ 93,530)   $  55,703
                                                   =========    =========    =========    =========    =========

Fixed charges:
    Interest expense                               $     281    $   2,657    $  11,859    $  11,932    $  12,175
    Interest capitalized                                  --           --          222          276           --
    Assumed interest component of rental charges       1,028        1,231        1,604        1,900        1,885
                                                   ---------    ---------    ---------    ---------    ---------
Total fixed charges                                $   1,309    $   3,888    $  13,685    $  14,108    $  14,060
                                                   =========    =========    =========    =========    =========

Ratio of earnings to fixed charges                    (A)          (A)          (A)          (A)         3.96



   
(A)   Due to the registrant's losses for the years ended December 31, 2000,
      2001, 2002, and 2003, the ratio coverage was less than 1:1. To achieve a
      coverage ratio of 1:1, the registrant must generate additional earnings of
      the amounts shown in the table below.




                                                             Years ended December 31,
                                                   ------------------------------------------------
                                                     2000          2001         2002        2003
                                                   ---------    ---------    ---------    ---------
                                                                              
Coverage deficiency                                $  17,077    $  75,178    $ 124,572    $ 107,638