MERRILL LYNCH, PIERCE, FENNER & MORGAN STANLEY & CO. INCORPORATED SMITH INCORPORATED 1585 BROADWAY 4 WORLD FINANCIAL CENTER NEW YORK, NY 10036 NEW YORK, NY 10080 July 18, 2005 VIA EDGAR Securities and Exchange Commission Division of Corporate Finance 450 Fifth Street, N.W. Washington, D.C. 20549 Attention: Jeffrey P. Riedler - Legal Joseph Roesler - Accounting Re: Adams Respiratory Therapeutics, Inc. Registration Statement on Form S-1 (File Number 333-123585) Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended (the "Act"), on behalf of Merrill Lynch, Pierce, Fenner & Smith Incorporated, Morgan Stanley & Co. Incorporated, Deutsche Bank Securities Inc. and RBC Capital Markets Corporation, we hereby join Adams Respiratory Therapeutics, Inc. (the "Company") in requesting that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 2:00 p.m. Eastern Time on July 20, 2005, or as soon thereafter as possible. In connection with this acceleration request and pursuant to Rule 460 under the Act, the following information is provided with respect to the distribution through 12:00 p.m. July 15, 2005 of the Preliminary Prospectus dated July 6, 2005: To Whom Distributed Number of Copies Underwriters 9,050 Dealers 0 Institutions 751 Individuals 12,614 Total 22,415 This is to further advise you that the underwriters have complied and will continue to comply with SEC release No. 33-4968 and Rule 15c2-8 under the Securities Exchange Act of 1934, as amended. Securities and Exchange Commission -2- July 18, 2005 The Commission is further advised that the amount of compensation to be allowed or paid to the underwriters, to be disclosed in the Prospectus filed pursuant to Rule 424(b) under the Act, will not exceed an amount that has been cleared with the National Association of Securities Dealers, Inc. Very truly yours, MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED MORGAN STANLEY & CO. INCORPORATED DEUTSCHE BANK SECURITIES INC. RBC CAPITAL MARKETS CORPORATION As Representatives of the several Underwriters By: MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED By: /s/ Samuel Thong __________________________________ Name: Samuel Thong Title: Director By: MORGAN STANLEY & CO. INCORPORATED By: /s/ William L. Blais __________________________________ Name: William L. Blais Title: Managing Director