EXHIBIT 23



            CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM


The Board of Directors
OSI Pharmaceuticals, Inc.:


We consent to the incorporation by reference in the registration statements on
Form S-8 (No. 333-129749, No. 333-91118, No. 333-65072, No. 333-42274, No.
333-39509, No. 333-06861, No. 33-64713, No. 33-38443) and on Form S-3
(333-124279) of OSI Pharmaceuticals, Inc. and subsidiaries of our reports dated
March 15, 2006, relating to (i) the consolidated balance sheets of OSI
Pharmaceuticals, Inc. and subsidiaries as of December 31, 2005 and 2004, and the
related consolidated statements of operations, stockholders' equity, and cash
flows, for the year ended December 31, 2005, for the three months ended December
31, 2004, and for each of the two fiscal years in the period ended September 30,
2004, and (ii) management's assessment of the effectiveness of internal control
over financial reporting as of December 31, 2005, and the effectiveness of
internal control over financial reporting as of December 31, 2005, which reports
appear in the December 31, 2005 Annual Report on Form 10-K/A of OSI
Pharmaceuticals, Inc. Our report described in (ii) above contains an explanatory
paragraph relating to the exclusion of internal control over financial reporting
associated with one entity acquired during 2005 from management's assessment and
our assessment of the effectiveness of internal control over financial reporting
of OSI Pharmaceuticals, Inc. as of December 31, 2005.

As discussed in note 1(b) to the consolidated financial statements, the Company
adopted EITF 00-21 "Revenue Arrangements with Multiple Deliverables" in fiscal
2004.

As discussed in note 1(j) to the consolidated financial statements, the Company
fully adopted the provisions of Statement of Financial Accounting Standards No.
142, "Goodwill and Other Intangible Assets" in fiscal 2003.




                                       /s/ KPMG LLP



Melville, New York
March 23, 2006