Exhibit 3.1

                      RESTATED CERTIFICATE OF INCORPORATION

                                       OF

                             PTC THERAPEUTICS, INC.

    (Pursuant to Sections 242 and 245 of the General Corporation Law of the
                               State of Delaware)

          PTC Therapeutics, Inc., a Delaware corporation, hereby certifies as
follows:

     1. The name of the corporation is PTC Therapeutics, Inc. (the
"Corporation"). The date of filing of the original Certificate of Incorporation
of the Corporation with the Secretary of State of the State of Delaware was
March 31, 1998.

     2. This Restated Certificate of Incorporation amends, restates and
integrates the provisions of said Certificate of Incorporation, as heretofore
amended, supplemented or restated, of said Corporation, and has been duly
adopted pursuant to a resolution adopted by the Board of Directors, and by not
less than a majority of all of the outstanding shares of stock of the
Corporation, acting by written consent in accordance with the provisions of
Section 228 of the General Corporation Law of the State of Delaware. Written
notice of the taking of such action has been given in accordance with Section
228(e) of the General Corporation Law of the State of Delaware.

          The text of the Certificate of Incorporation is hereby amended and
restated to read in full as follows:

     FIRST The name of the Corporation is:

                             PTC THERAPEUTICS, INC.

     SECOND The address, including street, number, city, and county, of the
registered office of the Corporation in the State of Delaware is 2711
Centerville Road, Suite 400, City of Wilmington, County of New Castle; and the
name of the registered agent of the Corporation in the State of Delaware is
Corporation Service Company.

     THIRD The nature of the business to be conducted and the purposes of the
Corporation are:

          To purchase or otherwise acquire, invest in, own, lease, mortgage,
pledge, sell, assign and transfer or otherwise dispose of, trade and deal in and
with real property and personal property of every kind, class and description
(including, without limitation, goods, wares and merchandise of every kind,
class and description), to manufacture goods, wares and merchandise of every
kind, class and description, both on its own account and for others;

          To make and perform agreements and contracts of every kind and
description; and



          Generally to engage in any lawful act or activity or carry on any
business for which corporations may be organized under the Delaware General
Corporation Law or any successor statute.

     FOURTH The total number of shares of all classes of stock which the
Corporation shall have authority to issue is 171,636,120, consisting of:

          18,228,538 shares of Common Stock, Zero Dollars and One Tenth Cent
($0.001) Par Value per share (the "Common Stock"); and

          A. 153,407,582 shares of preferred stock, Zero Dollars and One Tenth
Cent ($0.001) Par Value per share (the "Preferred Stock"), 750,000 shares of
which have been designated as Series A Convertible Preferred Stock ("Series A
Preferred Stock"), 187,500 shares of which have been designated as Series B
Convertible Preferred Stock ("Series B Preferred Stock"), 6,295,000 shares of
which have been designated as Series C Convertible Preferred Stock ("Series C
Preferred Stock"), 13,800,000 shares of which have been designated as Series D
Preferred Stock ("Series D Preferred Stock"), 128,242,850 shares of which have
been designated as Series E Convertible Preferred Stock ("Series E Preferred
Stock") and 4,132,232 shares of which have been designated as Series E-2
Convertible Preferred Stock ("Series E-2 Preferred Stock"). The Series A
Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock, Series E Preferred Stock and Series E-2 Preferred Stock are
collectively hereinafter referred to as the "Designated Preferred Stock".

          B. Common Stock.

          1. General. The voting, dividend and liquidation and other rights of
the holders of the Common Stock are expressly made subject to and qualified by
the rights of the holders of any series of Designated Preferred Stock.

          2. Voting Rights. The holders of record of the Common Stock are
entitled to one vote per share on all matters to be voted on by the
Corporation's stockholders.

          3. Dividends. Dividends may be declared and paid on the Common Stock
from funds lawfully available therefor if, as and when determined by the Board
of Directors in their sole discretion, subject to provisions of law, any
provision of this Restated Certificate of Incorporation, as amended from time to
time, and subject to the relative rights and preferences of any shares of
Designated Preferred Stock authorized, issued and outstanding hereunder.

          4. Liquidation. Upon the dissolution, liquidation or winding up of the
Corporation, whether voluntary or involuntary, holders of record of the Common
Stock will be entitled to receive pro rata all assets of the Corporation
available for distribution to its stockholders, subject, however, to the
liquidation rights of the holders of Designated Preferred Stock authorized,
issued and outstanding hereunder.


                                       2



          5. Reverse Stock Split. For the avoidance of doubt, this Fourth
Section, Subsection B reflects a reverse stock split of the Common Stock in
which each 30,000 authorized shares were converted and combined into one share
of the Corporation's Common Stock (the "Reverse Stock Split"). The Reverse Stock
Split was effectuated by the Company in a Certificate of Amendment of the
Restated Certificate of Incorporation filed with the Secretary of State of the
State of Delaware on December 29, 2004.

          C. Preferred Stock.

          The Preferred Stock may be issued from time to time in one or more
series. The Board of Directors is authorized, subject to any limitations
prescribed by law, to provide for the issuance of shares of Preferred Stock in
series, and by filing a certificate pursuant to the applicable law of the State
of Delaware (such certificate being hereafter referred to as a "Preferred Stock
Designation"), to establish from time to time the number of shares to be
included in each such series, and to fix the designation, powers, preferences
and rights of the shares of each such series and any qualifications, limitations
or restrictions thereof. In the event that at any time the Board of Directors
shall have established and designated one or more series of Preferred Stock
consisting of a number of shares less than all of the authorized number of
shares of Preferred Stock, the remaining authorized shares of Preferred Stock
shall be deemed to be shares of an undesignated series of Preferred Stock unless
and until designated by the Board of Directors as being part of a series
previously established or a new series then being established by the Board of
Directors. Notwithstanding the fixing of the number of shares constituting a
particular series of Preferred Stock (other than the Designated Preferred
Stock), the Board of Directors may at any time thereafter authorize an increase
or decrease in the number of shares of any such series except as set forth in
the Preferred Stock Designation for such series. In case the number of shares of
any series of Preferred Stock shall be so decreased, the shares constituting
such decrease shall resume the status of authorized undesignated Preferred Stock
unless and until designated by the Board of Directors as being a part of a
series previously established or a new series then being established by the
Board of Directors. The number of authorized shares of Preferred Stock may be
increased or decreased (but not below the number of shares thereof then
outstanding) by the affirmative vote of the holders of a majority of the
outstanding shares of capital stock and the affirmative vote of the holders of a
majority of the outstanding Designated Preferred Stock, voting together as a
single class on an as-converted to Common Stock basis. The date of the first
issuance of Series E-2 Preferred Stock pursuant to the Subscription Agreement,
dated September 21, 2005, by and among the Corporation and the other signatories
thereto (the "Subscription Agreement"), after giving effect thereto, is
hereinafter referred to as the "Effective Date".

          D. Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock, Series D Preferred Stock, Series E Preferred Stock and Series
E-2 Preferred Stock.

          1. Liquidation, Dissolution or Winding Up; Certain Mergers,
Consolidations and Asset Sales.


                                       3



          (a) In the event of any voluntary or involuntary liquidation,
dissolution or winding up of the Corporation, (together with a Reorganization as
defined in Article FOURTH, D Section 1(c) herein, each such event, a
"Liquidation Event"), the holders of shares of Series A Preferred Stock, Series
B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, Series E
Preferred Stock and Series E-2 Preferred Stock then outstanding shall be
entitled to be paid out of the assets of the Corporation available for
distribution to its stockholders, before any payment shall be made to the
holders of Common Stock or any other class or series of stock ranking on
liquidation junior to the Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock, Series D Preferred Stock, Series E Preferred Stock or
Series E-2 Preferred Stock (such Common Stock and other stock being collectively
referred to as "Junior Stock") by reason of their ownership thereof, an amount
equal to $1.00 per share in the case of the Series A Preferred Stock, $2.00 per
share in the case of the Series B Preferred Stock, $2.50 per share in the case
of the Series C Preferred Stock, $3.25 per share in the case of the Series D
Preferred Stock, $0.397644 in the case of the Series E Preferred Stock and $7.26
in the case of the Series E-2 Preferred Stock, (in each case subject to
appropriate adjustment in the event of any stock dividend, stock split,
combination or other similar recapitalization affecting such shares), plus any
dividends declared but unpaid on such shares. If, upon any Liquidation Event,
the remaining assets of the Corporation available for distribution to its
stockholders shall be insufficient to pay the holders of shares of Series A
Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock, Series E Preferred Stock and Series E-2 Preferred Stock the
full amount to which they shall be entitled, the remaining assets and funds of
the Corporation legally available for distribution shall be distributed first,
ratably among the holders of shares of Series E Preferred Stock and Series E-2
Preferred Stock in proportion to the respective amounts which would otherwise be
payable in respect of the shares of Series E Preferred Stock and Series E-2
Preferred Stock held by them upon such distribution if all amounts payable on or
with respect to such shares were paid in full, second, ratably among the holders
of shares of Series D Preferred Stock in proportion to the respective amounts
which would otherwise be payable in respect of the shares of Series D Preferred
Stock held by them upon such distribution if all amounts payable on or with
respect to such shares were paid in full and, third, ratably among the holders
of shares of Series A Preferred Stock, the Series B Preferred Stock and Series C
Preferred Stock and any class or series of stock ranking on a parity as to
liquidation with the Series A Preferred Stock, the Series B Preferred Stock and
the Series C Preferred Stock in proportion to the respective amounts which would
otherwise be payable in respect of the shares held by them upon such
distribution if all amounts payable on or with respect to such shares were paid
in full.

          (b) After the payment of all preferential amounts required to be paid
to the holders of Designated Preferred Stock, as set forth in Section 1(a)
above, upon a Liquidation Event, the holders of shares of Junior Stock then
outstanding shall be entitled to receive the remaining assets and funds of the
Corporation available for distribution to its stockholders.

          (c) A Reorganization (as defined below) shall be regarded as a
liquidation, dissolution or winding up of the affairs of the Corporation within
the meaning of this Section 1. For the purposes hereof, a "Reorganization" shall
mean a capital reorganization of the Common


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Stock (other than a subdivision, combination, recapitalization, reclassification
or exchange of shares provided for elsewhere in Section 2) or a consolidation or
merger of the Corporation, or a sale, lease or other disposition of all or
substantially all of the assets or intellectual property of the Corporation,
other than a reorganization, merger or consolidation of the Corporation in a
transaction in which the shareholders of the Corporation immediately prior to
the transaction possess more than 50% of the voting power of the surviving
entity (or parent, if any) immediately after the transaction. Notwithstanding
the foregoing, a Reorganization, as defined herein, shall not include any
reorganization, merger or consolidation involving (1) only a change in the state
of incorporation of the Corporation, (2) a merger of the Corporation with or
into a wholly-owned subsidiary of the Corporation which is incorporated in the
United States of America, or (3) an acquisition by the Corporation through a
merger, reorganization or consolidation, in which the Corporation is
substantively the surviving corporation and operates as a going concern, of
another corporation which is incorporated in the United States of America and
which is engaged in a business similar to or related to the business of the
Corporation and which does not involve a change in the terms of the Series A
Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock, the
Series D Preferred Stock, the Series E Preferred Stock, the Series E-2 Preferred
Stock or of the Common Stock and of which the stockholders of the Corporation
immediately prior to such acquisition possess at least 51% of the voting power
of the surviving entity immediately following the consummation of such
acquisition.

          2. Conversion. The holders of Designated Preferred Stock shall have
conversion rights as follows (the "Conversion Rights"):

          (a) Right to Convert; Conversion Price.

               (i) Each share of Series A Preferred Stock shall be convertible,
without the payment of any additional consideration by the holder thereof and at
the option of the holder thereof, at any time after the date of issuance of such
share, at the office of the Corporation or any transfer agent for the Series A
Preferred Stock, into such number of fully paid and non-assessable shares of
Common Stock as is determined by dividing $1.00 by the relevant Conversion
Price, determined as hereinafter provided, in effect at the time of conversion.
The Conversion Price for purposes of calculating the number of shares of Common
Stock deliverable upon conversion without the payment of any additional
consideration by the holder of Series A Preferred Stock (the "Series A
Conversion Price") shall be $12.00 as of the Effective Date. Such Series A
Conversion Price shall be subject to adjustment, in order to adjust the number
of shares of Common Stock into which the Series A Preferred Stock is
convertible, as hereinafter provided.

               (ii) Each share of Series B Preferred Stock shall be convertible,
without the payment of any additional consideration by the holder thereof and at
the option of the holder thereof, at any time after the date of issuance of such
share, at the office of the Corporation or any transfer agent for the Series B
Preferred Stock, into such number of fully paid and non-assessable shares of
Common Stock as is determined by dividing $2.00 by the relevant


                                       5



Conversion Price, determined as hereinafter provided, in effect at the time of
conversion. The Conversion Price for purposes of calculating the number of
shares of Common Stock deliverable upon conversion without the payment of any
additional consideration by the holder of Series B Preferred Stock (the "Series
B Conversion Price") shall be $15.00 as of the Effective Date. Such Series B
Conversion Price shall be subject to adjustment, in order to adjust the number
of shares of Common Stock into which the Series B Preferred Stock is
convertible, as hereinafter provided.

               (iii) Each share of Series C Preferred Stock shall be
convertible, without the payment of any additional consideration by the holder
thereof and at the option of the holder thereof, at any time after the date of
issuance of such share, at the office of the Corporation or any transfer agent
for the Series C Preferred Stock, into such number of fully paid and
non-assessable shares of Common Stock as is determined by dividing $2.50 by the
relevant Conversion Price, determined as hereinafter provided, in effect at the
time of conversion. The Conversion Price for purposes of calculating the number
of shares of Common Stock deliverable upon conversion without the payment of any
additional consideration by the holder of Series C Preferred Stock (the "Series
C Conversion Price") shall be $18.00 as of the Effective Date. Such Series C
Conversion Price shall be subject to adjustment, in order to adjust the number
of shares of Common Stock into which the Series C Preferred Stock is
convertible, as hereinafter provided.

               (iv) Each share of Series D Preferred Stock shall be convertible,
without the payment of any additional consideration by the holder thereof and at
the option of the holder thereof, at any time after the date of issuance of such
share, at the office of the Corporation or any transfer agent for the Series D
Preferred Stock, into such number of fully paid and non-assessable shares of
Common Stock as is determined by dividing $3.25 by the relevant Conversion
Price, determined as hereinafter provided, in effect at the time of conversion.
The Conversion Price for purposes of calculating the number of shares of Common
Stock deliverable upon conversion without the payment of any additional
consideration by the holder of Series D Preferred Stock (the "Series D
Conversion Price") shall be $21.00 as of the Effective Date. Such Series D
Conversion Price shall be subject to adjustment, in order to adjust the number
of shares of Common Stock into which the Series D Preferred Stock is
convertible, as hereinafter provided.

               (v) Each share of Series E Preferred Stock shall be convertible,
without the payment of any additional consideration by the holder thereof and at
the option of the holder thereof, at any time after the date of issuance of such
share, at the office of the Corporation or any transfer agent for the Series E
Preferred Stock, into such number of fully paid and non-assessable shares of
Common Stock as is determined by dividing $0.397644 by the relevant Conversion
Price, determined as hereinafter provided, in effect at the time of conversion.
The Conversion Price for purposes of calculating the number of shares of Common
Stock deliverable upon conversion without the payment of any additional
consideration by the holder of Series E Preferred Stock (the "Series E
Conversion Price") shall be $7.26 as of the Effective Date. Such Series E
Conversion Price shall be subject to adjustment, in order to adjust


                                       6



the number of shares of Common Stock into which the Series E Preferred Stock is
convertible, as hereinafter provided.

               (vi) Each share of Series E-2 Preferred Stock shall be
convertible, without the payment of any additional consideration by the holder
thereof and at the option of the holder thereof, at any time after the date of
issuance of such share, at the office of the Corporation or any transfer agent
for the Series E-2 Preferred Stock, into such number of fully paid and
non-assessable shares of Common Stock as is determined by dividing $7.26 by the
relevant Conversion Price, determined as hereinafter provided, in effect at the
time of conversion. The Conversion Price for purposes of calculating the number
of shares of Common Stock deliverable upon conversion without the payment of any
additional consideration by the holder of Series E-2 Preferred Stock (the
"Series E-2 Conversion Price") shall be $7.26 as of the Effective Date. Such
Series E-2 Conversion Price shall be subject to adjustment, in order to adjust
the number of shares of Common Stock into which the Series E-2 Preferred Stock
is convertible, as hereinafter provided.

          Each of the Series A Conversion Price, the Series B Conversion Price,
the Series C Conversion Price, the Series D Conversion Price, the Series E
Conversion Price and the Series E-2 Conversion Price is sometimes referred to
herein, as the context requires, as the "Conversion Price."

          (b) Mechanics of Conversion.

               (i) Before any holder of Designated Preferred Stock shall be
entitled to convert the same into full shares of Common Stock, such holder shall
surrender the certificate or certificates therefor, duly endorsed, at the office
of the Corporation or of any designated transfer agent, and shall give written
notice to the Corporation at such office that such holder elects to convert the
same and shall state therein the name of such holder or the name or names of the
nominees of such holder in which such holder wishes the certificate or
certificates for shares of Common Stock to be issued. No fractional shares of
Common Stock shall be issued upon conversion of any shares of Series A Preferred
Stock, Series B Preferred Stock, Series C Preferred Stock, Series D Preferred
Stock, Series E Preferred Stock or Series E-2 Preferred Stock. In lieu of any
fractional shares of Common Stock to which the holder would otherwise be
entitled, the Corporation shall pay cash equal to such fraction multiplied by
the then effective applicable Conversion Price. The Corporation shall, as soon
as practicable thereafter, issue and deliver at such office to such holder of
Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock,
Series D Preferred Stock, Series E Preferred Stock or Series E-2 Preferred Stock
or to such holder's nominee or nominees, a certificate or certificates for the
number of shares of Common Stock to which such holder shall be entitled as
aforesaid, together with cash in lieu of any fraction of a share. Such
conversion shall be deemed to have been made immediately prior to the close of
business on the date of such surrender of the shares of Series A Preferred
Stock, Series B Preferred Stock, Series C Preferred Stock, Series D Preferred
Stock, Series E Preferred Stock or Series E-2 Preferred Stock to be converted,
and the person or persons


                                       7



entitled to receive the shares of Common Stock issuable upon conversion shall be
treated for all purposes as the record holder or holders of such shares of
Common Stock on such date.

               (ii) The issuance or delivery of certificates for Common Stock
upon the conversion of shares of Designated Preferred Stock pursuant to this
Section D.2 shall be made without charge to the converting holder of shares of
Designated Preferred Stock for such certificates or for any tax in respect of
the issuance or delivery of such certificates or the securities represented
thereby, and such certificates shall be issued or delivered in the respective
names of, or (subject to compliance with the applicable provisions of federal
and state securities laws) in such names as may be directed by, the holders of
the shares of Designated Preferred Stock converted; provided, however, that the
Corporation shall not be required to pay any tax which may be payable in respect
of any transfer involved in the issuance and delivery of any such certificates
in a name other than that of the holder of the shares of Designated Preferred
Stock converted, and the Corporation shall not be required to issue or deliver
such certificate unless or until the entity or entities requesting the issuance
or delivery thereof shall have paid to the Corporation the amount of such tax or
shall have established to the reasonable satisfaction of the Corporation that
such tax has been paid.

          (c) Adjustments to Conversion Price for Diluting Issues.

               (i) Special Definitions. For the purposes of this Section 2(c),
the following definitions shall apply:

                    (1) "Additional Closing" means the consummation of the sale
     and issuance by the Corporation of shares of Series E-2 Preferred Stock
     pursuant to the Subscription Agreement and the acceptance by a person or
     persons of such shares, occurring after the date of the Initial Closing.

                    (2) "Additional Shares of Common Stock" means all shares of
     Common Stock issued (or, pursuant to Subsection 2(c)(iii) deemed to be
     issued) by the Corporation after the Effective Date, other than Excluded
     Securities.

                    (3) "Convertible Securities" means any evidences of
     indebtedness, shares (other than the Common Stock or the Designated
     Preferred Stock), or other securities directly or indirectly convertible
     into or exchangeable for the Common Stock.

                    (4) "Excluded Securities" means any of the following
     Securities:

                         (A) any dividend or distribution payable pro rata to
               all holders of Common Stock or Designated Preferred Stock of the
               Corporation after the Effective Date;


                                       8



                         (B) Up to 2,326,008 shares of Common Stock (subject to
               equitable adjustment in the event of any stock dividend, stock
               split, combination, reorganization, recapitalization or similar
               event involving a change in the Common Stock), including Options
               therefor, issued pursuant to the Corporation's 1998 Employee
               Director and Consultant Stock Option Plan (as amended from
               time-to-time); provided that, shares of Common Stock or Options
               therefor in excess of such 2,326,008 shares may be issued or
               issuable pursuant to the Corporation's 1998 Employee, Director
               and Consultant Stock Option Plan (as amended from time-to-time),
               or such other arrangements, contracts, or plans as are
               recommended by management and approved by the Board of Directors
               or compensation committee established by the Board of Directors,
               and not considered "Additional Shares of Common Stock" upon
               written consent of the holders of a majority of the Designated
               Preferred Stock;

                         (C) securities issued in connection with the conversion
               or exercise of any Option (including securities issued in
               connection with any subsequent conversion of the securities
               issued upon the exercise of such Option), Convertible Securities
               outstanding on the Effective Date (including those issued on the
               Effective Date and Series E-2 Preferred Stock issued at any
               Additional Closing) or Designated Preferred Stock;

                         (D) up to that number of shares of Common Stock or
               Options equal to 1% of the aggregate number of shares of
               outstanding Common Stock on an as-converted, fully-diluted basis
               (after giving effect to the issuance of the Series E-2 Preferred
               Stock) measured as of the date of the latest issuance of Series
               E-2 Preferred Stock issued after the Effective Date (subject to
               equitable adjustment in the event of any stock dividend, stock
               split, combination, reorganization, recapitalization or similar
               event involving a change in the Common Stock) to institutional
               lenders in connection with the establishment or maintenance by
               the Corporation of credit facilities, including equipment lease
               facilities, approved in each case by a majority of the Board of
               Directors of the Corporation;

                         (E) securities issued pursuant to a registered public
               offering, the closing of which is on or after the Effective Date;

                         (F) up to that number of shares of Common Stock or
               Options equal to 1% of the aggregate number of shares of
               outstanding Common Stock on an as-converted, fully-diluted basis
               (after giving effect to the issuance of the Series E-2 Preferred
               Stock) measured as of the date of the latest issuance of Series
               E-2 Preferred Stock in connection with the sale of Common Stock
               or Convertible Securities of the Corporation issued


                                       9



               after the Effective Date (subject to equitable adjustment in the
               event of any stock dividend, stock split, combination,
               reorganization, recapitalization or similar event involving a
               change in the Common Stock) to any licensor of technology or
               patent rights to the Corporation or to any collaborative partner
               or licensee with respect to the development or commercialization
               of products;

                         (G) up to that number of shares of Common Stock or
               Options equal to 4% of the aggregate number of shares of
               outstanding Common Stock on an as-converted, fully-diluted basis
               (after giving effect to the issuance of the Series E-2 Preferred
               Stock) measured as of the date of the latest issuance of Series
               E-2 Preferred Stock by the Corporation issued after the Effective
               Date (subject to equitable adjustment in the event of any stock
               dividend, stock split, combination, reorganization,
               recapitalization or similar event involving a change in the
               Common Stock) in connection with the acquisition of another
               business entity by merger, purchase of all or substantially all
               of its assets or acquisition of all or substantially all of the
               equity interest of such business entity; or

                         (H) shares of Series E-2 Preferred Stock issued at the
               Initial Closing or any Additional Closing for consideration of
               not less than $7.26 per share.

                    (5) "Initial Closing" means the first consummation of the
     sale and issuance by the Corporation of shares of Series E-2 Preferred
     Stock and the acceptance by a person or persons of such shares.

                    (6) "Option" means any right, option or warrant to subscribe
     for, purchase or otherwise acquire Common Stock, Preferred Stock or
     Convertible Securities (as defined below).

               (ii) No Adjustment of Conversion Price. No adjustment shall be
made in the Series A Conversion Price as a result of the issuance of Additional
Shares of Common Stock or otherwise, unless the consideration per share
determined pursuant to Subsection 2(c)(vi) for an Additional Share of Common
Stock issued or deemed to be issued by the Corporation is less than the Series A
Conversion Price in effect on the date of, and immediately prior to, the issue
of such Additional Shares of Common Stock. In addition, no adjustment shall be
made in the Series A Conversion Price as a result of the issuance of Additional
Shares of Common Stock or otherwise, if the right to such adjustment is waived
by the holders of at least a majority of the then-outstanding shares of Series A
Preferred Stock. No adjustment shall be made in the Series B Conversion Price as
a result of the issuance of Additional Shares of Common Stock or otherwise,
unless the consideration per share determined pursuant to Subsection 2(c)(vi)
for an Additional Share of Common Stock issued or deemed to be issued by the
Corporation is less than the Series B Conversion Price in effect on the date of,
and immediately prior to, the issue of such Additional Shares of Common Stock.
In addition, no adjustment shall be made in the Series B


                                       10



Conversion Price as a result of the issuance of Additional Shares of Common
Stock or otherwise, if the right to such adjustment is waived by the holders of
at least a majority of the then-outstanding shares of Series B Preferred Stock.
No adjustment shall be made in the Series C Conversion Price as a result of the
issuance of Additional Shares of Common Stock or otherwise, unless the
consideration per share determined pursuant to Subsection 2(c)(vi) for an
Additional Share of Common Stock issued or deemed to be issued by the
Corporation is less than the Series C Conversion Price in effect on the date of,
and immediately prior to, the issue of such Additional Shares of Common Stock.
In addition, no adjustment shall be made in the Series C Conversion Price as a
result of the issuance of Additional Shares of Common Stock or otherwise, if the
right to such adjustment is waived by the holders of at least a majority of the
then-outstanding shares of Series C Preferred Stock. No adjustment shall be made
in the Series D Conversion Price as a result of the issuance of Additional
Shares of Common Stock or otherwise, unless the consideration per share
determined pursuant to Subsection 2(c)(vi) for an Additional Share of Common
Stock issued or deemed to be issued by the Corporation is less than the Series D
Conversion Price in effect on the date of, and immediately prior to, the issue
of such Additional Shares of Common Stock. In addition, no adjustment shall be
made in the Series D Conversion Price as a result of the issuance of Additional
Shares of Common Stock or otherwise, if the right to such adjustment is waived
by the holders of at least a majority of the then-outstanding shares of Series D
Preferred Stock. No adjustment shall be made in the Series E Conversion Price as
a result of the issuance of Additional Shares of Common Stock or otherwise,
unless the consideration per share determined pursuant to Subsection 2(c)(vi)
for an Additional Share of Common Stock issued or deemed to be issued by the
Corporation is less than the Series E Conversion Price in effect on the date of,
and immediately prior to, the issue of such Additional Shares of Common Stock.
In addition, no adjustment shall be made in the Series E Conversion Price as a
result of the issuance of Additional Shares of Common Stock or otherwise, if
each of the following conditions are met: (w) the right to such adjustment is
waived by the holders of at least sixty-six and two-thirds percent (66 2/3%) of
the then-outstanding shares of Series E Preferred Stock, (x) in connection with
the same circumstances giving rise to the waiver referred to in subclause (w)
above, the holders of the Series C Preferred Stock waive their right to
adjustment of the Series C Conversion Price in accordance with the terms set
forth in this Subsection 2(c)(ii), (y) in connection with the same circumstances
giving rise to the waiver referred to in subclause (w) above, the holders of the
Series D Preferred Stock have waived their right to adjustment of the Series D
Conversion Price as provided in this Subsection 2(c)(ii) and (z) in connection
with the same circumstances giving rise to the waiver referred to in subclause
(w) above, the holders of the Series E-2 Preferred Stock have waived their right
to adjustment of the Series E-2 Conversion Price as provided in this Subsection
2(c)(ii). No adjustment shall be made in the Series E-2 Conversion Price as a
result of the issuance of Additional Shares of Common Stock or otherwise, unless
the consideration per share determined pursuant to Subsection 2(c)(vi) for an
Additional Share of Common Stock issued or deemed to be issued by the
Corporation is less than the Series E-2 Conversion Price in effect on the date
of, and immediately prior to, the issue of such Additional Shares of Common
Stock. In addition, no adjustment shall be made in the Series E-2 Conversion
Price as a result of the issuance of Additional Shares of Common Stock or
otherwise, if each of the following conditions are met: (w) the right to such
adjustment is waived by the holders of at least sixty-six and two-thirds


                                       11



percent (66 2/3%) of the then-outstanding shares of Series E-2 Preferred Stock,
(x) in connection with the same circumstances giving rise to the waiver referred
to in subclause (w) above, the holders of the Series C Preferred Stock waive
their right to adjustment of the Series C Conversion Price in accordance with
the terms set forth in this Subsection 2(c)(ii), (y) in connection with the same
circumstances giving rise to the waiver referred to in subclause (w) above, the
holders of the Series D Preferred Stock have waived their right to adjustment of
the Series D Conversion Price as provided in this Subsection 2(c)(ii) and (z) in
connection with the same circumstances giving rise to the waiver referred to in
subclause (w) above, the holders of the Series E Preferred Stock have waived
their right to adjustment of the Series E Conversion Price as provided in this
Subsection 2(c)(ii).

               (iii) Issue of Options, Preferred Stock and Convertible
Securities Deemed Issue of Additional Shares of Common Stock. If the Corporation
at any time or from time to time after the Effective Date shall issue any
Options, Preferred Stock or Convertible Securities, or shall fix a record date
for the determination of holders of any class of securities entitled to receive
any such Options, Preferred Stock or Convertible Securities, then the maximum
number of shares of the Common Stock (as set forth in the instrument relating
thereto without regard to any provision contained therein for a subsequent
adjustment of such number) issuable upon the exercise of such Options or, in the
case of Preferred Stock or Convertible Securities and Options therefor, the
conversion or exchange of such Preferred Stock or Convertible Securities, shall
be deemed to be Additional Shares of Common Stock issued as of the time of such
issue or, in case such a record date shall have been fixed, as of the close of
business on such record date, provided, that with respect to the Series A
Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock, the
Series D Preferred Stock, the Series E Preferred Stock and the Series E-2
Preferred Stock, as the case may be, no Additional Shares of Common Stock shall
be deemed to have been issued unless the consideration per share determined
pursuant to Subsection 2(c)(vi) for such Additional Shares of Common Stock would
be less than the Series A Conversion Price, Series B Conversion Price, Series C
Conversion Price, the Series D Conversion Price, the Series E Conversion Price
or the Series E-2 Conversion Price, as the case may be, in effect on the date of
and immediately prior to such issue, or such record date, as the case may be,
and provided, further, that in any such case in which Additional Shares of
Common Stock are deemed to be issued:

                    (1) No further adjustment in the Series A Conversion Price,
     the Series B Conversion Price, the Series C Conversion Price, the Series D
     Conversion Price, the Series E Conversion Price or the Series E-2
     Conversion Price, as the case may be, shall be made upon the subsequent
     issue of Preferred Stock, Convertible Securities or shares of the Common
     Stock, in each case, upon the exercise of such Options, conversion or
     exchange of such Preferred Stock or Convertible Securities;

                    (2) If such Options, Preferred Stock or Convertible
     Securities by their terms provide, with the passage of time or otherwise,
     for any increase or decrease, other than any decrease due to anti-dilution
     provisions, in the consideration payable to the Corporation, or decrease or
     increase, other than any increase due to anti-


                                       12



     dilution provisions, in the number of shares of the Common Stock issuable,
     upon the exercise, conversion or exchange thereof, the Series A Conversion
     Price, the Series B Conversion Price, the Series C Conversion Price, the
     Series D Conversion Price, the Series E Conversion Price and the Series E-2
     Conversion Price computed upon the original issue thereof (or upon the
     occurrence of a record date with respect thereto), and any subsequent
     adjustments based thereon, shall, upon the effectiveness of any such
     increase or decrease in consideration, or decrease or increase in the
     number of shares, be recomputed to reflect such increase or decrease in
     consideration, or decrease or increase in the number of shares, insofar as
     it affects such Options or the right of conversion or exchange under such
     Preferred Stock or Convertible Securities;

                    (3) Upon the expiration or termination of any such Options
     or any rights of conversion or exchange under such Preferred Stock or
     Convertible Securities which shall not have been exercised, the Series A
     Conversion Price, the Series B Conversion Price, the Series C Conversion
     Price, the Series D Conversion Price, the Series E Conversion Price or the
     Series E-2 Conversion Price, as the case may be, computed upon the original
     issue thereof (or upon the occurrence of a record date with respect
     thereto) and any subsequent adjustments based thereon shall, upon such
     expiration, be recomputed as if:

                         (A) In the case of Preferred Stock, Convertible
               Securities or Options for Common Stock, the only Additional
               Shares of Common Stock issued were the shares of the Common
               Stock, if any, actually issued upon the exercise of such Options
               or the conversion or exchange of such Preferred Stock or
               Convertible Securities and the consideration received therefor
               was the consideration actually received by the Corporation for
               the issue of all such Options, whether or not exercised, plus the
               consideration actually received by the Corporation upon such
               exercise, or for the issue of all such Preferred Stock or
               Convertible Securities which were actually converted or
               exchanged, plus the additional consideration, if any, actually
               received by the Corporation upon such conversion or exchange; and

                         (B) In the case of Options for Preferred Stock or
               Convertible Securities, only the Preferred Stock or Convertible
               Securities, if any, actually issued upon the exercise thereof
               were issued at the time of issue of such Options, and the
               consideration received by the Corporation for the Additional
               Shares of Common Stock deemed to have been then issued was the
               consideration actually received by the Corporation for the issue
               of all such Options, whether or not exercised, plus the
               consideration deemed to have been received by the Corporation
               determined pursuant to Subsection 2(c)(iii) upon the issue of the
               Preferred Stock or Convertible Securities with respect to which
               such Options were actually exercised;


                                       13



                    (4) No recomputation pursuant to Subsection 2(c)(iii)(2) or
     Subsection 2(c)(iii)(3) above shall have the effect of (A) increasing the
     Series A Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series A Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series A Conversion Price that would have
     resulted from any issuance of Additional Shares of Common Stock between the
     original adjustment date and such recomputation date, (B) increasing the
     Series B Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series B Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series B Conversion Price that would have
     resulted from any issuance of Additional Shares of Common Stock between the
     original adjustment date and such recomputation date, (C) increasing the
     Series C Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series C Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series C Conversion Price that would have
     resulted from any issuance of Additional Shares of Common Stock between the
     original adjustment date and such recomputation date, (D) increasing the
     Series D Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series D Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series D Conversion Price that would have
     resulted from any issuance of Additional Shares of Common Stock between the
     original adjustment date and such recomputation date (E) increasing the
     Series E Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series E Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series E Conversion Price that would have
     resulted from any issuance of Additional Shares of Common Stock between the
     original adjustment date and such recomputation date or (F) increasing the
     Series E-2 Conversion Price to an amount that exceeds the lower of (i) the
     applicable Series E-2 Conversion Price prior to the original adjustment for
     such deemed issuance, or (ii) the Series E-2 Conversion Price that would
     have resulted from any issuance of Additional Shares of Common Stock
     between the original adjustment date and such recomputation date; and

                    (5) If such record date shall have been fixed and such
     Options, Preferred Stock or Convertible Securities are not issued on the
     date fixed therefor, the adjustment previously made in the Series A
     Conversion Price, Series B Conversion Price, Series C Conversion Price,
     Series D Conversion Price, Series E Conversion Price or Series E-2
     Conversion Price which became effective on such record date shall be
     canceled as of the close of business on such record date, and thereafter
     the Series A Conversion Price, Series B Conversion Price, Series C
     Conversion Price, Series D Conversion Price, Series E Conversion Price or
     Series E-2 Conversion Price shall be adjusted pursuant to this Subsection
     2(c)(iii) as of the actual date of their issuance.

               (iv) Stock Dividends and Stock Distributions. In case the
Corporation shall at any time or from time to time after the Effective Date
distribute to all holders of shares of its Common Stock (including any such
distribution made in connection with a consolidation or merger in which the
Corporation is the resulting or surviving corporation and the Common Stock is
not changed or exchanged) cash, evidences of indebtedness of the Corporation or
another


                                       14



issuer, securities of the Corporation or another issuer or other assets
(excluding (A) dividends or distributions paid or made to holders of shares of
Designated Preferred Stock in the manner provided in Section 4(a), and (B)
dividends payable in shares of Common Stock (or any options, warrants or other
rights to acquire Common Stock) for which adjustment is made under another
clause of this Section 2(c)(iv)), then, and in each such case, the Conversion
Price then in effect shall be adjusted by multiplying the Conversion Price in
effect immediately prior to the date of such distribution by a fraction (x) the
numerator of which shall be such Current Market Price of one share of the Common
Stock less the then Fair Market Value (as determined by the Board of Directors
of the Corporation) of the portion of the cash, evidences of indebtedness,
securities or other assets so distributed or of such subscription rights or
warrants applicable to one share of Common Stock and (y) the denominator of
which shall be the Current Market Price of the Common Stock on the record date
referred to below (but such denominator not to be less than one). Such
adjustment shall be made whenever any such distribution is made and shall become
effective retroactively to a date immediately following the close of business on
the record date for the determination of stockholders entitled to receive such
distribution. If such record date shall have been fixed and such dividend or
distribution shall not have been fully paid on the date fixed therefor, the
adjustment previously made in the Series A Conversion Price, Series B Conversion
Price, Series C Conversion Price, Series D Conversion Price, Series E Conversion
Price or Series E-2 Conversion Price which became effective on such record date
shall be canceled as of the close of business on such record date, and
thereafter the Series A Conversion Price, Series B Conversion Price, Series C
Conversion Price, Series D Conversion Price, Series E Conversion Price or Series
E-2 Conversion Price shall be adjusted pursuant to this Subsection 2(c)(iv) as
of the time of actual payment of such dividend.

          For purposes of this Section 2(c)(iv), the following definitions shall
apply:

                         (A) "Current Market Price" per share shall mean, on any
               date specified herein for the determination thereof, (a) the
               average daily Market Price of the Common Stock for those days
               during the period of 5 days, ending on such date, which are days
               on which national securities exchanges in the United States are
               open for trading, and (b) if the Common Stock is not then listed
               or admitted to trading on any national securities exchange or
               quoted in the over-the-counter market, the Market Price on such
               date.

                         (B) "Fair Market Value" shall mean (x) if available,
               the Current Market Price (determined without reference to the
               last sentence of the definition of Market Price) or (y) if there
               shall be no Current Market Price available, the amount which a
               willing buyer, under no compulsion to buy, would pay a willing
               seller, under no compulsion to sell, in an arm's-length
               transaction (assuming (i) that the Common Stock is valued "as if
               fully distributed" and (ii) no consideration is given for
               minority investment discounts, or discounts related to
               illiquidity or restrictions on transferability).


                                       15



                         (C) "Market Price" shall mean, per share of Common
               Stock on any date specified herein: (a) the closing price per
               share of the Common Stock on such date published in The Wall
               Street Journal or, if no such closing price on such date is
               published in The Wall Street Journal, the average of the closing
               bid and asked prices on such date, as officially reported on the
               principal national securities exchange on which the Common Stock
               is then listed or admitted to trading, (b) if the Common Stock is
               not then listed or admitted to trading on any national securities
               exchange but is designated as a national market system security,
               the last trading price of the Common Stock on such date, or (c)
               if there shall have been no trading on such date or if the Common
               Stock is not so designated, the average of the reported closing
               bid and asked prices of the Common Stock on such date as shown by
               NASDAQ and reported by any member firm of the NYSE, selected by
               the Corporation. If neither (a), (b) or (c) is applicable, Market
               Price shall mean the Fair Market Value per share determined in
               good faith by the Board of Directors of the Corporation which
               shall be deemed to be Fair Market Value unless holders of at
               least a majority of the outstanding shares of Designated
               Preferred Stock request, in writing, that the Corporation obtain
               an opinion of an investment banking firm chosen by the Company,
               which is reasonably satisfactory to such holders, (at the
               Corporation's expense), in which event Fair Market Value shall be
               as determined by such investment banking firm.

                         (D) "NASDAQ" shall mean the National Market System of
               The NASDAQ Stock Market, Inc.

                         (E) "NYSE" shall mean The New York Stock Exchange, Inc.

               (v) Adjustment of Conversion Price Upon Certain Events. If, after
the Effective Date, the Corporation shall issue Additional Shares of Common
Stock, including Additional Shares of Common Stock deemed to be issued pursuant
to Subsection 2(c)(iii) hereof, but excluding events described in Subsection
2(d) (which event is dealt with in such Subsection):

                    (1) Without consideration or for a consideration per share
     less than the Series A Conversion Price in effect immediately prior to such
     issue, then and in such event, the Series A Conversion Price shall be
     reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series A Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series A Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the


                                       16



     number of shares of the Common Stock which the aggregate consideration
     received by the Corporation for the total number of Additional Shares of
     Common Stock so issued would purchase at the Series A Conversion Price in
     effect immediately prior to such issue and (y) the denominator of which
     shall be (A) the number of shares of the Common Stock outstanding
     immediately prior to such issue (including shares of Common Stock issuable
     upon exercise or conversion of any outstanding Options, Designated
     Preferred Stock or Convertible Securities) plus (B) the number of such
     Additional Shares of Common Stock so issued or deemed to be issued.

                    (2) Without consideration or for a consideration per share
     less than the Series B Conversion Price in effect immediately prior to such
     issue, then and in such event, the Series B Conversion Price shall be
     reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series B Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series B Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the number of shares of the
     Common Stock which the aggregate consideration received by the Corporation
     for the total number of Additional Shares of Common Stock so issued would
     purchase at the Series B Conversion Price in effect immediately prior to
     such issue and (y) the denominator of which shall be (A) the number of
     shares of the Common Stock outstanding immediately prior to such issue
     (including shares of Common Stock issuable upon exercise or conversion of
     any outstanding Options, Designated Preferred Stock or Convertible
     Securities) plus (B) the number of such Additional Shares of Common Stock
     so issued or deemed to be issued.

                    (3) Without consideration or for a consideration per share
     less than the Series C Conversion Price in effect immediately prior to such
     issue, then and in such event, the Series C Conversion Price shall be
     reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series C Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series C Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the number of shares of the
     Common Stock which the aggregate consideration received by the Corporation
     for the total number of Additional Shares of Common Stock so issued would
     purchase at the Series C Conversion Price in effect immediately prior to
     such issue and (y) the denominator of which shall be (A) the number of
     shares of the Common Stock outstanding immediately prior to such issue
     (including shares of Common Stock issuable upon exercise or conversion of
     any outstanding Options, Designated Preferred


                                       17


     Stock or Convertible Securities) plus (B) the number of such Additional
     Shares of Common Stock so issued or deemed to be issued.

                    (4) Without consideration or for a consideration per share
     less than the Series D Conversion Price in effect immediately prior to such
     issue, then and in such event, the Series D Conversion Price shall be
     reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series D Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series D Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the number of shares of the
     Common Stock which the aggregate consideration received by the Corporation
     for the total number of Additional Shares of Common Stock so issued would
     purchase at the Series D Conversion Price in effect immediately prior to
     such issue and (y) the denominator of which shall be (A) the number of
     shares of the Common Stock outstanding immediately prior to such issue
     (including shares of Common Stock issuable upon exercise or conversion of
     any outstanding Options, Designated Preferred Stock or Convertible
     Securities) plus (B) the number of such Additional Shares of Common Stock
     so issued or deemed to be issued.

                    (5) Without consideration or for a consideration per share
     less than the Series E Conversion Price in effect immediately prior to such
     issue, then and in such event, the Series E Conversion Price shall be
     reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series E Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series E Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the number of shares of the
     Common Stock which the aggregate consideration received by the Corporation
     for the total number of Additional Shares of Common Stock so issued would
     purchase at the Series E Conversion Price in effect immediately prior to
     such issue and (y) the denominator of which shall be (A) the number of
     shares of the Common Stock outstanding immediately prior to such issue
     (including shares of Common Stock issuable upon exercise or conversion of
     any outstanding Options, Designated Preferred Stock or Convertible
     Securities) plus (B) the number of such Additional Shares of Common Stock
     so issued or deemed to be issued. For the avoidance of doubt, any
     adjustment to the Series E Conversion Price in connection with the issuance
     of Additional Shares of Common Stock (and/or deemed issuance pursuant to
     Subsection 2(c)(iii) hereof) for cash or other consideration shall be made
     in accordance with Subsection 2(c)(v)(7).


                                       18



                    (6) Without consideration or for a consideration per share
     less than the Series E-2 Conversion Price in effect immediately prior to
     such issue, then and in such event, the Series E-2 Conversion Price shall
     be reduced, concurrently with such issue in order to increase the number of
     shares of Common Stock into which a share of Series E-2 Preferred Stock is
     convertible, to a price (calculated at least to the nearest 1/100th of a
     cent) determined by multiplying the Series E-2 Conversion Price in effect
     immediately prior to such issue by a fraction (x) the numerator of which
     shall be (A) the number of shares of Common Stock outstanding immediately
     prior to such issue (including shares of the Common Stock issuable upon
     exercise or conversion of any outstanding Options, Designated Preferred
     Stock or Convertible Securities) plus (B) the number of shares of the
     Common Stock which the aggregate consideration received by the Corporation
     for the total number of Additional Shares of Common Stock so issued would
     purchase at the Series E-2 Conversion Price in effect immediately prior to
     such issue and (y) the denominator of which shall be (A) the number of
     shares of the Common Stock outstanding immediately prior to such issue
     (including shares of Common Stock issuable upon exercise or conversion of
     any outstanding Options, Designated Preferred Stock or Convertible
     Securities) plus (B) the number of such Additional Shares of Common Stock
     so issued or deemed to be issued. For the avoidance of doubt, any
     adjustment to the Series E-2 Conversion Price in connection with the
     issuance of Additional Shares of Common Stock (and/or deemed issuance
     pursuant to Subsection 2(c)(iii) hereof) for cash or other consideration
     shall be made in accordance with Subsection 2(c)(v)(8).

                    (7) Notwithstanding anything to the contrary set forth in
     Subsections 2(c)(v)(5) or 2(c)(v)(6), if the Corporation shall issue (or be
     deemed to have issued pursuant to Subsection 2(c)(iii) hereof) Additional
     Shares of Common Stock (other than in connection with any issuance or
     deemed issuance where the securities issued, but for the number of shares
     issued or deemed issued, would constitute an Excluded Security) for cash or
     other consideration (including any Options issued in connection therewith)
     per share less than the Series E Conversion Price in effect immediately
     prior to such issuance, then, and in such event, the Series E Conversion
     Price shall be reduced to equal the price per share of the Additional
     Shares of Common Stock so issued.

                    (8) Notwithstanding anything to the contrary set forth in
     Subsections 2(c)(v)(5) or 2(c)(v)(6), if the Corporation shall issue (or be
     deemed to have issued pursuant to Subsection 2(c)(iii) hereof) Additional
     Shares of Common Stock (other than in connection with any issuance or
     deemed issuance where the securities issued, but for the number of shares
     issued or deemed issued, would constitute an Excluded Security) for cash or
     other consideration (including any Options issued in connection therewith)
     per share less than the Series E-2 Conversion Price in effect immediately
     prior to such issuance, then, and in such event, the Series E-2 Conversion
     Price shall be reduced to equal the price per share of the Additional
     Shares of Common Stock so issued.


                                       19



               (vi) Determination of Consideration. For purposes of Subsection
2(c)(v), the consideration received by the Corporation for the issue of any
Additional Shares of Common Stock shall be computed as follows:

                    (1) Cash and Property: Such consideration shall:

                         (A) Insofar as it consists of cash, be computed at the
               aggregate of cash received by the Corporation, excluding amounts
               paid or payable for accrued interest or accrued dividends;

                         (B) Insofar as it consists of property other than cash,
               be computed at the fair market value thereof at the time of such
               issue, as determined in good faith by the Board of Directors; and

                         (C) In the event Additional Shares of Common Stock are
               issued together with other shares or securities or other assets
               of the Corporation for consideration which covers both, be the
               proportion of such consideration, computed as provided in
               Subsections 2(c)(vi)(1)(A) and 2(c)(vi)(1)(B) above, received in
               respect of the Additional Shares of Common Stock, as determined
               in good faith by the Board of Directors;

                    (2) Options, Designated Preferred Stock and Convertible
     Securities. The consideration per share received by the Corporation for
     Additional Shares of Common Stock deemed to have been issued pursuant to
     Subsection 2(c)(iii), relating to Options, Designated Preferred Stock and
     Convertible Securities, shall be determined by dividing:

                         (A) The total amount, if any, received or receivable by
               the Corporation as consideration for the issue of such Options,
               Designated Preferred Stock or Convertible Securities, plus the
               minimum aggregate amount of additional consideration (as set
               forth in the instruments relating thereto, without regard to any
               provision contained therein for a subsequent adjustment of such
               consideration until such subsequent adjustment occurs) payable to
               the Corporation upon the exercise of such Options or the
               conversion or exchange of such Designated Preferred Stock or
               Convertible Securities, or in the case of Options for Designated
               Preferred Stock or Convertible Securities, the exercise of such
               Options for Designated Preferred Stock or Convertible Securities
               and the conversion or exchange of such Designated Preferred Stock
               or Convertible Securities, by

                         (B) The maximum number of shares of the Common Stock
               (as set forth in the instruments relating thereto, without regard
               to any provision contained therein for a subsequent adjustment of
               such number until such subsequent adjustment occurs) issuable
               upon the exercise of such Options or the conversion or exchange
               of such


                                       20



               Designated Preferred Stock or Convertible Securities and, in the
               case of Options for Preferred Stock or Convertible Securities,
               the exercise of such Options for Preferred Stock or Convertible
               Securities and the conversion or exchange of such Preferred Stock
               or Convertible Securities.

          (d) Adjustment for Stock Splits, Stock Dividends, Subdivisions,
Combinations or Consolidation of Common Stock. In the event that at any time or
from time to time after the Effective Date the outstanding shares of the Common
Stock shall be split, subdivided, combined or consolidated, by reclassification
or otherwise, into a greater or lesser number of shares of Common Stock, and in
the event that the Corporation shall issue shares of the Common Stock by way of
a stock dividend or other distribution to the holders of the Common Stock, the
Series A Conversion Price, Series B Conversion Price, Series C Conversion Price,
Series D Conversion Price, Series E Conversion Price and Series E-2 Conversion
Price in effect immediately prior to such split, subdivision, stock dividend,
combination or consolidation shall, concurrently with the effectiveness of such
split, subdivision, stock dividend, combination or consolidation, be increased
or decreased proportionately, so that the holder of any share of Designated
Preferred Stock thereafter surrendered for conversion shall be entitled to
receive (in lieu of the number of shares of Common Stock that the holders would
otherwise have been entitled to receive) the number of shares of Common Stock or
other securities of the Corporation that such holder would have owned or would
have been entitled to receive upon or by reason of any of the events described
above, had such share of Designated Preferred Stock been converted immediately
prior to the occurrence of such event.

          (e) Automatic Conversion.

               (i) Each share of Series A Preferred Stock, Series B Preferred
Stock, Series C Preferred Stock, Series D Preferred Stock, Series E Preferred
Stock and Series E-2 Preferred Stock shall automatically be converted into
shares of Common Stock at the then effective relevant Conversion Price upon
either (i) the closing of a firm commitment underwritten public offering
pursuant to an effective registration statement under the Securities Act of
1933, as amended, covering the offer and sale of Common Stock for the account of
the Corporation to the public at an initial public offering price per share of
not less than an amount equal to two times the Series E-2 Conversion Price then
in effect with net proceeds to the Corporation of not less than $50,000,000 or
(ii) any other public offering upon the written election of the Company and
holders of at least sixty-six and two-thirds percent (66 2/3 %) of the
outstanding shares of Preferred Stock, voting together on an as-converted basis
(a "Qualified Initial Public Offering").

               (ii) Each share of Series A Preferred Stock, Series B Preferred
Stock, and Series C Preferred Stock shall automatically be converted into shares
of Common Stock at the then relevant Conversion Price upon the written election
of the holders of not less than sixty-six and two-thirds percent (66 2/3%) in
voting power of the then outstanding shares of Series A Preferred Stock, Series
B Preferred Stock and Series C Preferred Stock voting together, treating all
such shares as if converted, to require such mandatory conversion.


                                       21



               (iii) Each share of Series D Preferred Stock shall automatically
be converted into shares of Common Stock at the then relevant Series D
Conversion Price upon the written election of the holders of not less than
sixty-six and two-thirds percent (66 2/3%) in voting power of the then
outstanding shares of Series D Preferred Stock, voting as a separate class,
treating all such shares as if converted, to require such mandatory conversion.

               (iv) Each share of Series E Preferred Stock and Series E-2
Preferred Stock shall automatically be converted into shares of Common Stock at
the then relevant Series E Conversion Price and Series E-2 Conversion Price,
respectively, upon the written election of the holders of not less than
sixty-six and two-thirds percent (66 2/3%) in voting power of the then
outstanding shares of Series E Preferred Stock and Series E-2 Preferred Stock,
voting together, treating all such shares as if converted, to require such
mandatory conversion.

               (v) Upon the occurrence of an event specified in Sections 2(e)(i)
or 2(e)(ii) in the case of Series A Preferred Stock, Series B Preferred Stock
and Series C Preferred Stock or 2(e)(iii) in the case of Series D Preferred
Stock or 2(e)(iv) in the case of Series E Preferred Stock and Series E-2
Preferred Stock all applicable shares of Series A Preferred Stock, Series B
Preferred Stock and Series C Preferred Stock, or Series D Preferred Stock,
Series E Preferred Stock or Series E-2 Preferred Stock, as the case may be,
shall be converted automatically without any further action by any holder of
such shares and whether or not the certificate or certificates representing such
shares are surrendered to the Corporation or the designated transfer agent,
provided, however, that the Corporation shall not be obligated to issue a
certificate or certificates evidencing the shares of Common Stock into which
such shares of Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock, Series D Preferred Stock, Series E Preferred Stock or Series
E-2 Preferred Stock, as the case may be, are converted unless the certificate or
certificates representing such shares of Series A Preferred Stock, Series B
Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, Series E
Preferred Stock or Series E-2 Preferred Stock, as the case may be, being
converted are either delivered to the Corporation or the transfer agent, or the
holder notifies the Corporation or such transfer agent that such certificate or
certificates have been lost, stolen, or destroyed and executes and delivers an
agreement satisfactory to the Corporation to indemnify the Corporation from any
loss incurred by it in connection therewith and, if the Corporation so elects,
provides an appropriate indemnity.

               (vi) Upon the automatic conversion of Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock,
Series E Preferred Stock and Series E-2 Preferred Stock, as the case may be,
each holder of Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock, Series D Preferred Stock, Series E Preferred Stock and Series
E-2 Preferred Stock, as the case may be, shall surrender the certificate or
certificates representing such holder's shares of Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock,
Series E Preferred Stock and Series E-2 Preferred Stock, as the case may be, at
the office of the Corporation or of the transfer agent for such shares.
Thereupon, there shall be issued and delivered to such holder, promptly at such
office and in such holder's name as shown on such surrendered certificate or
certificates, a


                                       22



certificate or certificates for the number of shares of Common Stock into which
the shares of Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock, Series D Preferred Stock Series E Preferred Stock and Series
E-2 Preferred Stock, as the case may be, surrendered were convertible on the
date on which such automatic conversion occurred. No fractional shares of Common
Stock shall be issued upon the automatic conversion of Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock,
Series E Preferred Stock or Series E-2 Preferred Stock. In lieu of any
fractional shares of Common Stock to which the holder would otherwise be
entitled, the Corporation shall pay cash equal to such fraction multiplied by
the then effective Conversion Price.

          (f) In case of any capital reorganization or reclassification or other
change of outstanding shares of Common Stock (other than (i) a change in par
value, or from par value to no par value, or from no par value to par value or
(ii) a split, subdivision, combination or consolidation of shares of Common
Stock provided for in Section D.2(d) of this Article FOURTH), or in case of any
consolidation or merger of the Corporation with or into another entity (other
than a consolidation or merger in which the Corporation is the resulting or
surviving corporation and which does not result in any reclassification or
change of outstanding Common Stock), or in case of any sale, lease or other
disposition to another entity of all or substantially all of the assets or
intellectual property of the Corporation (any of the foregoing but excluding a
Reorganization (as defined in Section D.1(c) of this Article FOURTH), a
"Transaction"), the Corporation, or such successor or purchasing entity, as the
case may be, shall execute and deliver to each holder of Designated Preferred
Stock at least 10 business days prior to effecting any of the foregoing
Transactions a certificate that the holder of each share of Designated Preferred
Stock then outstanding shall have the right thereafter to convert such share of
Designated Preferred Stock into the kind and amount of shares of stock or other
securities (of the Corporation or another issuer) or property or cash receivable
upon such Transaction by a holder of the number of shares of Common Stock into
which such share of Designated Preferred Stock could have been converted
immediately prior to such Transaction. Such certificate shall provide for
adjustments which shall be as nearly equivalent as may be practicable to the
adjustments provided for in Section D.2(c)(v) of this Article FOURTH. If, in the
case of any such Transaction, the stock, other securities, cash or property
receivable thereupon by a holder of Common Stock includes shares of stock or
other securities of an entity other than the successor or purchasing entity and
other than the Corporation, which controls or is controlled by the successor or
purchasing entity or which, in connection with such Transaction, issues stock,
securities, other property or cash to holders of Common Stock, then such
certificate also shall be executed by such entity, and such entity shall, in
such certificate, specifically acknowledge the obligations of such successor or
purchasing entity and acknowledge its obligations to issue such stock,
securities, other property or cash to the holders of Designated Preferred Stock
upon conversion of the shares of Designated Preferred Stock as provided above.
The provisions of this Section D.2(f) and any equivalent thereof in any such
certificate shall apply similarly to successive Transactions. Compliance with
this Section D.2(f) shall be a condition for any Transaction.


                                       23



          (g) Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the relevant Conversion Price pursuant to this
Section 2, the Corporation at its expense shall promptly compute such adjustment
or readjustment in accordance with the terms hereof and furnish to each affected
holder of Designated Preferred Stock, a certificate setting forth such
adjustment or readjustment and showing in detail the facts upon which such
adjustment or readjustment is based. The Corporation shall, upon the written
request at any time of any affected holder of Designated Preferred Stock furnish
to such holder a like certificate setting forth (i) such adjustments and
readjustments, (ii) the Conversion Price at the time in effect and (iii) the
number of shares of Common Stock and the amount, if any, of other property which
at the time would be received upon conversion of each share of Designated
Preferred Stock.

          (h) Notices of Record Date. In the event that this Corporation shall
propose at any time:

               (i) to declare any dividend or distribution upon its Common
Stock, whether in cash, property, stock, or other securities, whether or not a
regular cash dividend and whether or not out of earnings or earned surplus;

               (ii) to offer for subscription pro rata to the holders of any
class or series of its stock any additional shares of stock of any class or
series or other rights, warrants, options or other securities;

               (iii) to effect any reclassification or recapitalization of its
Common Stock outstanding involving a change in the Common Stock; or

               (iv) to engage in any Reorganization or Transaction, or to
liquidate, dissolve, or wind up; then, in connection with each such event, this
Corporation shall send to the holders of the Designated Preferred Stock:

                    (1) at least 10 days' prior written notice of the date on
     which a record shall be taken for such dividend, distribution, or
     subscription rights (and specifying the date on which the holders of Common
     Stock shall be entitled thereto) or for determining rights to vote in
     respect of the matters referred to in (iii) and (iv) above; and

                    (2) in the case of the matters referred to in (iii) and (iv)
     above, at least 10 days' prior written notice of the date when the same
     shall take place (and specifying the date on which the holders of Common
     Stock shall be entitled to exchange their Common Stock for securities or
     other property deliverable upon the occurrence of such event or the record
     date for the determination of such holders if such record date is earlier).

          Each such written notice shall be delivered personally by carrier
service providing evidence of delivery or given by first class mail, postage
prepaid, addressed to the holders of the


                                       24



Designated Preferred Stock at the address for each such holder as shown on the
books of this Corporation; provided, however, that United States mail shall not
be used to effectuate the delivery of any such to addresses outside the United
States. Each such written notice shall state (x) the date on which a record is
to be taken for the purpose of such dividend, distribution or rights, warrants,
options or other securities, or if a record is not to be taken, the date as of
which the holders of Common Stock of record to be entitled to such dividend,
distribution or rights, warrants, options or other securities are to be
determined, or (y) the date on which such Reorganization, Transaction,
reclassification, recapitalization, dissolution, liquidation or winding up is
expected to become effective. Such notice also shall specify the date as of
which it is expected that holders of Common Stock of record shall be entitled to
exchange their Common Stock for shares of stock or other securities or property
or cash deliverable upon such Reorganization, Transaction, reclassification,
recapitalization, dissolution, liquidation or winding up.

          (i) Common Stock Reserved. The Corporation shall reserve and keep
available out of its authorized but unissued Common Stock such number of shares
of Common Stock as shall from time to time be sufficient to effect the
conversion of all outstanding shares of Designated Preferred Stock, and shall
take all action required to increase the authorized number of shares of Common
Stock if at any time there shall be insufficient authorized but unissued shares
of Common Stock to permit such reservation or to permit the conversion of all
outstanding shares of Designated Preferred Stock.

          (j) Certain Taxes. The Corporation shall pay any issue or transfer
taxes payable in connection with the conversion of any shares of Designated
Preferred Stock, provided, however, that the Corporation shall not be required
to pay any tax which may be payable in respect of any transfer to a name other
than that of the holder of such Designated Preferred Stock.

          (k) Closing of Books. The Corporation shall at no time close its
transfer books against the transfer of any Designated Preferred Stock, or of any
shares of Common Stock issued or issuable upon the conversion of any shares of
Designated Preferred Stock in any manner which interferes with the timely
conversion or transfer of such Designated Preferred Stock.

          (l) No Impairment. The Corporation shall not, by amendment of its
Certificate of Incorporation (other than by amendment approved by the Designated
Preferred Stock in accordance with the provisions of this Certificate of
Incorporation) or through any reorganization, transfer of assets, consolidation,
merger, dissolution, issue or sale of securities or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms to be
observed or performed hereunder by the Corporation but shall at all times in
good faith assist in the carrying out of all the provisions of this Section 2
and in the taking of all such action as may be necessary or appropriate in order
to protect the conversion rights of the holders of Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock,
Series E Preferred Stock and Series E-2 Preferred Stock against impairment.


                                       25



          3. Voting Rights.

          (a) Except as otherwise provided by applicable law and this Restated
Certificate of Incorporation, each holder of outstanding shares of Designated
Preferred Stock shall be entitled to the number of votes equal to the number of
whole shares of Common Stock into which the shares of Designated Preferred Stock
held by such holder are convertible (as adjusted from time to time pursuant to
Section 2 hereof) as of the record date, at each meeting of stockholders of the
Corporation (and written actions of stockholders in lieu of meetings) with
respect to any and all matters presented to the stockholders of the Corporation
for their action or consideration. Except as provided by law or by the
provisions of Section 3(b), (c), (d), (e) and (f) below or by the provisions
establishing any other series of stock, holders of Designated Preferred Stock
and of any other outstanding series of stock shall vote together with the
holders of Common Stock as a single class on an as-converted to Common Stock
basis.

          (b) Notwithstanding the provisions of Section 3(a), at each annual or
special meeting called for the purpose of electing directors, the holders of the
Designated Preferred Stock, voting as a single class, shall be entitled to elect
five (5) members of the Board of Directors and the holders of the Common Stock
shall be entitled to elect two (2) members of the Board of Directors and the
remaining directors shall be elected by the holders of Designated Preferred
Stock and the holders of Common Stock voting together as a single class. The
provisions of this Section 3(b) shall expire and be of no further force or
effect upon conversion of all outstanding shares of Designated Preferred Stock
into Common Stock pursuant to the provisions of Section 2(a) or 2(e) hereof. In
the case of any vacancy in the office of a director elected by a specified group
of stockholders, a successor shall be elected to hold office for the unexpired
term of such director by the affirmative vote of a majority of the shares of
such specified group given at a special meeting of such stockholders duly called
or by an action by written consent for that purpose. Any director who shall have
been elected by a specified group of stockholders may be removed during the
aforesaid term of office, either for or without cause, by, and only by, the
affirmative vote of the holders of a majority of the shares of such specified
group, given at a special meeting of such stockholders duly called or by an
action by written consent for that purpose, and any such vacancy thereby
created, may be filled by the vote of the holders of a majority of the shares of
such specified group represented at such meeting or in such consent.

          (c) The Corporation shall not, without first having obtained the
affirmative vote or written consent of a majority in voting power of the
outstanding shares of Designated Preferred Stock, voting together as a single
class on an as-converted to Common Stock basis:

               (i) Subject to the additional restrictions set forth in Sections
D.3(e) and (f) of this Article FOURTH, redeem, purchase or otherwise acquire for
value (or pay into or set aside for a sinking fund for such purpose) any shares
of Designated Preferred Stock otherwise than by conversion in accordance with
Section D.2 of this Article FOURTH;

               (ii) Authorize or issue, or obligate itself to issue, any other
equity security (including any security convertible into or exercisable for any
equity security) senior to


                                       26



or on a parity with any of the Designated Preferred Stock as to dividend rights,
redemption rights, liquidation preferences, voting rights, where any equity
security issued shall have more than one vote for each such security issued or
be convertible into a voting security which has more than one vote for such
equity security issued, or conversion rights, where any equity security issued
shall be convertible into more than one voting equity security, except for
adjustments made to all Preferred Stock in connection with (A) any stock split,
reverse stock split or like transaction, or (B) any dilutive issuances;

               (iii) Make any redemption, repurchase, payment of dividends or
other distributions with respect to Common Stock (except for acquisitions of
Common Stock by the Corporation pursuant to agreements which permit the
Corporation to repurchase such shares upon termination of services to the
Corporation or in exercise of the Corporation's right of first refusal upon a
proposed transfer);

               (iv) Effect any sale, lease, transfer or other conveyance of all
or substantially all of the assets or intellectual property of the Corporation
or any of its subsidiaries, or any consolidation or merger involving the
Corporation or any of its subsidiaries, or any reclassification or
recapitalization of the Corporation;

               (v) Increase the number of shares reserved under the Company's
1998 Employee, Director and Consultant Stock Option Plan (as amended from
time-to-time); or

               (vi) Increase the number of authorized shares of Preferred Stock.

          (d) The Corporation shall not, without first having obtained the
affirmative vote or written consent of a majority in voting power of the
outstanding shares of Series D Preferred Stock, Series E Preferred Stock and
Series E-2 Preferred Stock, voting together as a single class on an as converted
to Common Stock basis:

               (i) Alter or change the preferences, rights, privileges or powers
of, or the restrictions provided for the benefit of, the Series D Preferred
Stock, the Series E Preferred Stock or the Series E-2 Preferred Stock in a
material and adverse way;

               (ii) Authorize or issue, or obligate itself to issue, any other
equity security (including any security convertible into or exercisable for any
equity security) senior to or on a parity with any of the Series D Preferred
Stock, the Series E Preferred Stock or Series E-2 Preferred Stock as to dividend
rights, redemption rights, liquidation preferences, voting rights, where any
equity security issued shall have more than one vote for each such security
issued or be convertible into a voting security which has more than one vote for
such equity security issued, or conversion rights, where any equity security
issued shall be convertible into more than one voting equity security, except
for adjustments made to all Preferred Stock in connection with (A) any stock
split, reverse stock split or like transaction, or (B) any dilutive issuances;

               (iii) Increase or decrease the authorized number of shares of the
Series D Preferred Stock, the Series E Preferred Stock or the Series E-2
Preferred Stock;


                                       27



               (iv) Amend, alter or repeal any provision of the Restated
Certificate of Incorporation or the Corporation's Bylaws so as to adversely
affect the rights, powers, preferences and privileges of the Series D Preferred
Stock, the Series E Preferred Stock or the Series E-2 Preferred Stock
(including, without limitation, by merger, reconsolidation, recapitalization or
other transactions);

               (v) Effect any sale, lease, transfer or other conveyance of all
or substantially all of the Corporation's assets or intellectual property or
consummate a transaction which results in the holders of the Corporation's
capital stock prior to the transaction owning less than 50% of the voting power
of the Corporation's capital stock after the transaction;

               (vi) Increase or decrease the number of members of the
Corporation's Board of Directors from nine (9); or

               (vii) Effect a substantial change in the principal business of
the Corporation so that the principal business of the Corporation is no longer
related to the discovery, licensing, development and manufacturing of
prophylactic, therapeutic or diagnostic products; provided, that, such consent
shall not be required if the Corporation's Board of Directors has unanimously
approved such change in the Corporation's business.

          (e) The Corporation shall not, without first having obtained the
affirmative vote or written consent of sixty-six and two-thirds percent (66
2/3%) of the voting power of the outstanding shares of Series D Preferred Stock,
voting on an as converted to Common Stock basis, redeem, purchase or otherwise
acquire for value (or pay or set aside for a sinking fund or for any purpose)
any shares of Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock or any Junior Stock prior to redeeming, purchasing or otherwise
acquiring for value all of the outstanding shares of Series D Preferred Stock;
provided, however, that any Junior Stock subject to a restriction agreement (or
equivalent terms in any option agreement) may be reacquired by the Corporation
pursuant to the terms of such agreement, if, in the judgment of the Board of
Directors, such reacquisition is in the best interest of the stockholders.

          (f) The Corporation shall not, without first having obtained the
affirmative vote or written consent of sixty-six and two-thirds percent
(66-2/3%) of the voting power of the outstanding shares of Series E Preferred
Stock and Series E-2 Preferred Stock, voting together as a single class on an as
converted to Common Stock basis, (i) notwithstanding anything to the contrary
set forth in Subsection 3(d)(iv), amend the definition of Liquidation Event set
forth in Subsection 1(a) or Subsection 1(c), or (ii) redeem, purchase or
otherwise acquire for value (or pay or set aside for a sinking fund or for any
purpose) any shares of Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock, Series D Preferred Stock or any Junior Stock prior to
redeeming, purchasing or otherwise acquiring for value all of the outstanding
shares of Series E Preferred Stock and Series E-2 Preferred Stock, provided,
however, that any Junior Stock subject to a restriction agreement (or equivalent
terms in any option agreement) may be reacquired by the Corporation pursuant to
the terms of such agreement, if, in the judgment of the Board of Directors, such
reacquisition is in the best interest of the stockholders.


                                       28



          (g) The Corporation shall not, without first having obtained the
affirmative vote or written consent of seventy-five percent (75%) of the voting
power of the outstanding shares of Series E Preferred Stock, voting on an as
converted to Common Stock basis, amend the requirements with respect to the
effectiveness of any waivers of adjustments to the Series E Conversion Price as
a result of the issuance of Additional Shares of Common Stock or otherwise set
forth in Subsection 2(c)(ii).

          (h) The Corporation shall not, without first having obtained the
affirmative vote or written consent of seventy-five percent (75%) of the voting
power of the outstanding shares of Series E-2 Preferred Stock, voting on an as
converted to Common Stock basis, amend the requirements with respect to the
effectiveness of any waivers of adjustments to the Series E-2 Conversion Price
as a result of the issuance of Additional Shares of Common Stock or otherwise
set forth in Subsection 2(c)(ii).

          Notwithstanding the foregoing, approval of a majority of the voting
power of any series of Preferred Stock, voting as a single class, shall be
required for any action that (i) materially and adversely affects holders of
such series in a different manner than other series of Designated Preferred
Stock; provided, however, that the determination of whether any holder of
Preferred Stock or group of such holders is affected differently shall be made
without regard to the number of shares of Shares held by such holder or group of
holders; (ii) increases the Conversion Price of such series or (iii) alters or
changes the liquidation preferences of any such series.

          4. Dividends.

          (a) The Corporation shall not declare or pay any dividends or
distributions (as defined below) on shares of Common Stock unless the holders of
the Series A Preferred Stock, Series B Preferred Stock, Series C Preferred
Stock, Series D Preferred Stock, Series E Preferred Stock and Series E-2
Preferred Stock then outstanding shall have first received, or simultaneously
receive, a like distribution on each outstanding share of Series A Preferred
Stock, Series B Preferred Stock, Series C Preferred Stock, Series D Preferred
Stock, Series E Preferred Stock and Series E-2 Preferred Stock in an amount at
least equal to the product of (i) the per share amount, if any, of the dividends
or distributions to be declared or paid on the Common Stock, multiplied by (ii)
the number of whole shares of Common Stock into which such share of Series A
Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock, Series E Preferred Stock or Series E-2 Preferred Stock is
convertible as of the record date for such dividend or distribution.

          (b) The Corporation shall not declare or pay any dividends or
distributions on shares of Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock, Series D Preferred Stock. Series E Preferred Stock or
Series E-2 Preferred Stock unless the holders of the other series of Designated
Preferred Stock shall have first received, or simultaneously receive, a like
distribution on each outstanding share of Series A Preferred Stock, Series B
Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, Series E
Preferred Stock or Series E-2


                                       29



Preferred Stock, as the case may be, in an equal amount; provided, however, the
Corporation shall not pay any dividends or distributions on any shares of Series
A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock or any Junior Stock prior to paying in full such equal dividends
or distributions on all of the outstanding shares of the Series E Preferred
Stock and Series E-2 Preferred Stock; provided, further, the Corporation shall
not pay any dividends or distributions on any shares of Series A Preferred
Stock, Series B Preferred Stock, Series C Preferred Stock or any Junior Stock
prior to paying in full such equal dividends or distributions on all of the
outstanding shares of the Series D Preferred Stock. For purposes of this Section
4(b), the determination of whether such dividends or distributions are equal in
amount shall be made based on a comparison of the product of (i) the amount per
share of Designated Preferred Stock of the dividends or distributions to be
declared or set aside multiplied by (ii) the number of whole shares of Common
Stock into which such share of Designated Preferred Stock is convertible as of
the record date for such dividend or distribution.

          (c) For purposes of this Section 4, "distribution" shall mean the
transfer of cash or property without consideration, whether by way of dividend
or otherwise, or the purchase or redemption of shares of the Corporation (other
than repurchases of Common Stock held by employees or directors of, or
consultants to, the Corporation upon termination of their employment or services
pursuant to agreements approved by the Board of Directors providing for such
repurchase at a price equal to the original issue price of such shares or at
fair market value, provided such repurchase at fair market value is approved by
the Board of Directors) for cash or property, including any such transfer,
purchase or redemption by a subsidiary of the Corporation.

          5. No Reissuance of Designated Preferred Stock. No share or shares of
Preferred Stock acquired by the Corporation by reason of redemption, purchase,
conversion or otherwise shall be reissued, and all such shares shall be
canceled, retired and eliminated from the shares which the corporation shall be
authorized to issue.

          6. Residual Rights. All rights accruing to the outstanding shares of
the Corporation not expressly provided for in the terms of the Series A
Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D
Preferred Stock, Series E Preferred Stock and Series E-2 Preferred Stock shall
be vested in the Common Stock.

          7. Increasing Common Stock. The number of authorized shares of Common
Stock may be increased or decreased (but not below the number of shares of
Common Stock then outstanding) by an affirmative vote of the holders of a
majority of the Common Stock and the Designated Preferred Stock, voting together
as a single class, on an as-converted basis.

     FIFTH The Corporation is to have perpetual existence.

     SIXTH For the management of the business and for the conduct of the affairs
of the Corporation, and in further definition and not in limitation of the
powers of the Corporation and of its directors and of its stockholders or any
class thereof, as the case may be, conferred by the State of Delaware, it is
further provided that:


                                       30



          A. The management of the business and the conduct of the affairs of
the Corporation shall be vested in its Board of Directors. The number of
directors which shall constitute the whole Board of Directors shall be fixed by,
or in the manner provided in, the By-Laws. The phrase "whole Board" and the
phrase "total number of directors" shall be deemed to have the same meaning, to
wit, the total number of directors which the Corporation would have if there
were no vacancies. No election of directors need be by written ballot.

          B. After the original or other By-Laws of the Corporation have been
adopted, amended or repealed, as the case may be, in accordance with the
provisions of Section 109 of the General Corporation Law of the State of
Delaware, and, after the Corporation has received any payment for any of its
stock, the power to adopt, amend, or repeal the By-Laws of the Corporation may
be exercised by the Board of Directors of the Corporation.

          C. The books of the Corporation may be kept at such place within or
without the State of Delaware as the By-Laws of the Corporation may provide or
as may be designated from time to time by the Board of Directors of the
Corporation.

     SEVENTH The Corporation shall, to the fullest extent permitted by Section
145 of the General Corporation Law of the State of Delaware, as the same may be
amended and supplemented from time to time, indemnify and advance expenses to,
(i) its directors and officers and (ii) any person who at the request of the
Corporation is or was serving as a director, officer, employee or agent of
another corporation, partnership, joint venture, trust or other enterprise, from
and against any and all of the expenses, liabilities, or other matters referred
to in or covered by said section as amended or supplemented (or any successor),
provided, however, that except with respect to proceedings to enforce rights to
indemnification, the By-Laws of the Corporation may provide that the Corporation
shall indemnify any director, officer or such person in connection with a
proceeding (or part thereof) initiated by such director, officer or such person
only if such proceeding (or part thereof) was authorized by the Board of
Directors of the Corporation. The Corporation, by action of its Board of
Directors, may provide indemnification or advance expenses to employees and
agents of the Corporation or other persons only on such terms and conditions and
to the extent determined by the Board of Directors in its sole and absolute
discretion. The indemnification provided for herein shall not be deemed
exclusive of any other rights to which those indemnified may be entitled under
any By-Law, agreement, vote of stockholders or disinterested directors or
otherwise, both as to action in their official capacity and as to action in
another capacity while holding such office, and shall continue as to a person
who has ceased to be a director, officer, employee, or agent and shall inure to
the benefit of the heirs, executors and administrators of such a person.

     EIGHTH No director of this Corporation shall be personally liable to the
Corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director except to the extent that exemption from liability or
limitation thereof is not permitted under the General Corporation Law of the
State of Delaware as in effect at the time such liability or limitation thereof
is determined. No amendment, modification or repeal of this Article shall apply
to or have any effect on the liability or alleged liability of any director of
the Corporation for or with


                                       31



respect to any acts or omissions of such director occurring prior to such
amendment, modification or repeal. If the General Corporation Law of the State
of Delaware is amended after approval by the stockholders of this Article to
authorize corporate action further eliminating or limiting the personal
liability of directors, then the liability of a director of the Corporation
shall be eliminated or limited to the fullest extent permitted by the General
Corporation Law of the State of Delaware, as so amended.

     NINTH Whenever a compromise or arrangement is proposed between this
Corporation and its creditors or any class of them and/or between this
Corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this Corporation or of any creditor or stockholder thereof or on the
application of any receiver or receivers appointed for this Corporation under
the provisions of Section 291 of Title 8 of the Delaware Code or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this Corporation under the provisions of Section 279 of Title 8 of the
Delaware Code, order a meeting of the creditors or class of creditors, and/or of
the stockholders or class of stockholders of this Corporation, as the case may
be, to be summoned in such manner as the said court directs. If a majority in
number representing three-fourths (3/4) in value of the creditors or class of
creditors, and/or of the stockholders or class of stockholders of this
Corporation, as the case may be, agree to any compromise or arrangement and to
any reorganization of this Corporation as consequence of such compromise or
arrangement, the said compromise or arrangement and the said reorganization
shall, if sanctioned by the court to which the said application has been made,
be binding on all the creditors or class of creditors, and/or on all the
stockholders or class of stockholders, of this Corporation, as the case may be,
and also on this Corporation.

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                                       32



          IN WITNESS WHEREOF, the Corporation has caused this Restated
Certificate of Incorporation to be signed by its duly authorized officer this
21st day of September, 2005.

                                        PTC THERAPEUTICS, INC.


                                        By: /S/ STUART W. PELTZ
                                            ------------------------------------
                                        Name: Stuart W. Peltz
                                        Title: President