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.
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Exhibit 4.1
[AMICUS THERAPEUTICS, INC. LOGO]
NUMBER SHARES
A
<Table>
INCORPORATED UNDER THE LAWS AMICUS THERAPEUTICS, INC. CUSIP 03152W 10 9
OF THE STATE OF DELAWARE SEE REVERSE FOR CERTAIN DEFINITIONS
</Table>
THIS CERTIFIES THAT
is the owner of
FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK,
$.01 PAR VALUE PER SHARE, OF
- ----------=================AMICUS THERAPEUTICS, INC.=================---------
transferable on the books of the Corporation by said owner in person or by his
duly authorized attorney upon the surrender of this certificate properly
endorsed. This certificate is not valid until countersigned by the Transfer
Agent and registered by the Registrar.
Witness the facsimile of the Corporation's seal and the facsimile
signatures of its duly authorized officers.
Dated:
<Table>
- ----------------------- -------------------------- -------------------------------------
/s/ Illegible Signature [AMICUS THERAPEUTICS SEAL] /s/ Illegible Signature
SECRETARY PRESIDENT AND CHIEF EXECUTIVE OFFICER
</Table>
COUNTERSIGNED AND REGISTERED
AMERICAN STOCK TRANSFER & TRUST COMPANY
(New York, NY)
TRANSFER AGENT AND REGISTRAR
BY:
AUTHORIZED SIGNATURE
AMICUS THERAPEUTICS, INC.
The Corporation will furnish without charge to each stockholder who so requests
a statement of the powers, designations, preferences and relative,
participating, optional, or other special rights of each class of stock or
series thereof and the qualifications, limitations or restrictions of such
preferences and/or rights. Any such request should be addressed to the Secretary
of the Corporation at its principal place of business.
The following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:
<Table>
<Caption>
TEN COM -- as tenants in common UNIF GIFT MIN ACT-- Custodian
---------- --------
TEN ENT -- as tenants by the entireties (Cust) (Minor)
JT TEN -- as joint tenants with right of under Uniform Gifts to Minors
survivorship and not as tenants
in common Act
----------------------------------------
(State)
UNIF TRANS MIN ACT-- Custodian
--------- --------
(Cust) (Minor)
under Uniform Transfers to Minors
Act
----------------------------------
(State)
</Table>
Additional abbreviations may also be used though not in the above list.
For value received, ____________________________________________hereby sell(s),
assign(s) and transfer(s) unto
PLEASE INSERT SOCIAL SECURITY OR OTHER
IDENTIFYING NUMBER OF ASSIGNEE
- --------------------------------------
- --------------------------------------
- --------------------------------------------------------------------------------
(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
shares
- ------------------------------------------------------------------------
of the common stock represented by the within Certificate, and do hereby
irrevocably constitute and appoint
Attorney
- ------------------------------------------------------------------------
to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.
Dated
---------------------------
------------------------------------------------------------
THE SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND
NOTICE: WITH THE NAME(S) AS WRITTEN UPON THE FACE OF
THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT
ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.
SIGNATURE(S) GUARANTEED
By
-------------------------------------------------------------------------
THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION,
(Banks, Stockbrokers, Savings and Loan Associations and Credit Unions) WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM PURSUANT TO
S.E.C. RULE 17Ad-15.