1
 
    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 25, 1995
                                                    REGISTRATION NO. 33-59949-01
- - --------------------------------------------------------------------------------
- - --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
 
                         POST-EFFECTIVE AMENDMENT NO. 1
                                       ON
 
                                    FORM S-8
                                       TO
 
                                    FORM S-4
                             REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933*
                            ------------------------
 
                                GENENTECH, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
 

                                             
                    DELAWARE                                       94-2347624
            (STATE OF INCORPORATION)                  (I.R.S. EMPLOYER IDENTIFICATION NO.)

 
                            ------------------------
 
                         460 POINT SAN BRUNO BOULEVARD
                     SOUTH SAN FRANCISCO, CALIFORNIA 94080
                                 (415) 225-1000
         (ADDRESS AND TELEPHONE NUMBER OF PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------
 
                            1991 EMPLOYEE STOCK PLAN
                           (FULL TITLE OF THE PLANS)
 
                          STEPHEN G. JUELSGAARD, ESQ.
                       VICE PRESIDENT AND GENERAL COUNSEL
                                GENENTECH, INC.
                         460 POINT SAN BRUNO BOULEVARD
                         SOUTH SAN FRANCISCO, CA 94080
                                 (415) 225-1000
 (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE,
                             OF AGENT FOR SERVICE)
 
                            ------------------------
 
                        CALCULATION OF REGISTRATION FEE
 


- - ------------------------------------------------------------------------------------------------------
- - ------------------------------------------------------------------------------------------------------
                                                    PROPOSED MAXIMUM PROPOSED MAXIMUM
                                                     OFFERING PRICE      AGGREGATE       AMOUNT OF
TITLE OF SECURITIES                   AMOUNT TO BE         PER           OFFERING       REGISTRATION
TO BE REGISTERED                       REGISTERED         SHARE          PRICE(2)          FEE(2)
- - ------------------------------------------------------------------------------------------------------
                                                                             
Callable Putable Common Stock
  (par value $.02)(1).............  1,573,360 shares      N.A.(2)         N.A.(2)         N.A.(2)
- - ------------------------------------------------------------------------------------------------------
- - ------------------------------------------------------------------------------------------------------

 
(1) This Registration Statement also relates to the 1,573,360 shares of Common
    Stock, par value $.02, of the Registrant into which the 1,573,360 shares of
    Callable Putable Common Stock offered hereby are subject to conversion in
    accordance with the Certificate of Incorporation of the Registrant.
 
(2) All filing fees payable in connection with registration of these securities
    were paid in connection with the filing of (a) the Registrant's Schedule 14A
    dated June 2, 1995, (b) the Registrant's Form S-4, No. 33-59949, dated June
    5, 1995 (the "Form S-4") and (c) Amendment No. 1 to the Form S-4 dated
    September 8, 1995.
 
     APPROXIMATE DATE OF COMMENCEMENT OF THE PROPOSED SALE OF SECURITIES
PURSUANT TO THE PLAN: Promptly after the filing of this Post-Effective
Amendment.
 
* Filed as a Post-Effective Amendment on Form S-8 to such Form S-4 Registration
  Statement pursuant to the procedure described herein. See "INTRODUCTORY
  STATEMENT".
- - --------------------------------------------------------------------------------
- - --------------------------------------------------------------------------------
   2
 
                             INTRODUCTORY STATEMENT
 
     Genentech, Inc. (the "Company" or the "Registrant") hereby amends its
Registration Statement on Form S-4 (No. 33-59949) (the "Form S-4"), by filing
this Post-Effective Amendment No. 1 on Form S-8 ("Amendment No. 1") relating to
the sale of up to 1,573,360 shares of Callable Putable Common Stock, par value
$.02 per share ("Special Common Stock") issuable in connection with the
Company's 1991 Employee Stock Plan (the "Plan"). This Amendment No. 1 also
relates to the sale of a like number of shares of the Company's Common Stock,
par value $.02 per share ("Common Stock"), into which the Special Common Stock
issuable in connection with the Plan is subject to conversion in accordance with
the Company's Certificate of Incorporation. All of such shares were previously
registered under the Form S-4.
 
     On October 25, 1995, HLR (U.S.) II, Inc., a Delaware corporation and a
wholly owned subsidiary of Roche Holdings, Inc., a Delaware corporation
("Roche"), was merged into the Company (the "Merger"). As a result of the
Merger, each outstanding share of Common Stock (other than shares held by Roche
and its affiliates) was converted into one share of Special Common Stock. As a
result of the Merger, shares of Common Stock will no longer be issued pursuant
to the Plan. Instead, participants in the Plan will receive, in lieu of each
share of Common Stock which would have been acquired under the Plan, one share
of Special Common Stock.
 
     The designation of Amendment No. 1 as Registration No. 33-59949-01 denotes
that Amendment No. 1 relates only to the shares of Special Common Stock (or,
upon conversion thereof, Common Stock) issuable pursuant to the Plan and that
this is the first Post-Effective Amendment to the Form S-4 filed with respect to
such shares.
 
ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.
 
     The following documents which have heretofore been filed by the Company
with the Securities and Exchange Commission (the "Commission") pursuant to the
Securities Exchange Act of 1934, as amended (the "1934 Act"), are incorporated
by reference herein and shall be deemed to be a part hereof:
 
          1.  The Company's Annual Report on Form 10-K for the year ended
     December 31, 1994;
 
          2.  The Company's Annual Report to Stockholders for the year ended
     December 31, 1994;
 
          3.  The Company's Quarterly Report on Form 10-Q for the quarter ended
     March 31, 1995;
 
          4.  The Company's Quarterly Report on Form 10-Q for the quarter ended
     June 30, 1995;
 
          5.  The Company's Proxy Statement relating to Genentech's 1995 Annual
     Meeting of Stockholders;
 
          6.  The description of the Special Common Stock contained in
     Genentech's Registration Statement filed pursuant to the 1934 Act, and any
     amendment or report filed for the purpose of updating such description;
 
          7.  The Company's Current Reports on Form 8-K dated July 10, 1995 and
     July 18, 1995;
 
          8.  Amendment No. 1 on Form 10-K/A-1 (filed on September 18, 1995)
     amending the Annual Report on Form 10-K of the Company for the year ended
     December 31, 1994; and
 
          9.  Amendment No. 1 on Form 10-Q/A-1 (filed on September 18, 1995)
     amending the Quarterly Report on Form 10-Q of the Company for the quarter
     ended March 31, 1995.
 
     All documents filed by the Company with the Commission pursuant to Sections
13(a), 13(c), 14 and 15(d) of the 1934 Act prior to the filing of a
post-effective amendment to this Registration Statement which indicates that all
securities offered have been sold or which deregisters all securities then
remaining unsold shall be deemed to be incorporated by reference in this
Registration Statement and made a part hereof from their respective dates of
filing (such documents, and the documents enumerated above, being hereinafter
referred to as "Incorporated Documents"); provided, however, that the documents
enumerated above or subsequently filed by the Company of the 1934 Act in each
year during which the offering made by this Registration Statement is in effect
prior to the filing with the Commission of the Company's Annual Report
   3
 
on Form 10-K covering such year shall not be incorporated Documents or be
incorporated by reference in this Registration Statement or be a part hereof
from and after the filing of such Annual Report on Form 10-K.
 
     Any statement contained in an Incorporated Document shall be deemed to be
modified or superseded for purposes of this Registration Statement to the extent
that a statement contained herein or in any other subsequently filed
Incorporated Document modifies or supersedes such statement. Any such statement
so modified or superseded shall not be deemed, except as so modified or
superseded, to constitute a part of this Registration Statement.
 
ITEM 4.  DESCRIPTION OF SECURITIES.
 
     Not Applicable.
 
ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.
 
     Not Applicable.
 
ITEM 6.  INDEMNIFICATION OF OFFICERS AND DIRECTORS.
 
     The Company's Certificate of Incorporation empowers the Company to
indemnify any director, officer, employee or agent of the Company or any other
person who is serving at the Company's request in any such capacity with another
corporation, partnership, joint venture, trust or other enterprise (including,
without limitation, an employee benefit plan) to the fullest extent permitted
under the Delaware General Corporation law (the "DGCL") as the same exists or
may be amended (but, in the case of any such amendment, only to the extent that
such amendment permits the Company to provide broader indemnification rights
than said law permitted the Company to provide prior to such amendment), and any
such indemnification shall continue as to any person who has ceased to be a
director, officer, employee or agent and may inure to the benefit of the heirs,
executors and administrators of such a person.
 
     The Company's Certificate of Incorporation also empowers the Company to
purchase and maintain insurance, at its expense, to protect itself and any
director, officer, employee or agent of the Company or another corporation,
partnership, joint venture, trust or other enterprise against any such expense,
liability or loss, whether or not the Company would have the power to indemnify
any such person against such expense, liability or loss under the DGCL.
 
     In addition, the By-Laws of the Company provide that the Company may
purchase and maintain insurance on behalf of any person who is or was a
director, officer, employee or agent of the Company or is or was serving at the
request of the Company as a director, officer, employee or agent of another
corporation, partnership, joint venture, trust or other enterprise against any
liability asserted against him and incurred by him in any such capacity, or
arising out of his status as such, whether or not the Company would have the
power to indemnify him against such liability under the provisions of the DGCL.
 
ITEM 8. EXHIBITS.
 


        EXHIBIT
        NUMBER
        -------
                 
         5-A(1)     Opinion of Counsel
        15-A(1)     Letter re: unaudited financial information
        23-A(1)     Consent of Ernst & Young LLP, independent auditors
        23-B(1)     Consent of Counsel is contained in Exhibit 5-A(1) to this Registration
                    Statement
        25-A(1)     Power of Attorney is contained on the signature pages to this
                    Registration Statement
        99-A(1)     1991 Employee Stock Plan, as amended and restated as of October 25, 1995

 
                                        2
   4
 
ITEM 9.  UNDERTAKINGS.
 
     The Registrant hereby undertakes:
 
          (1) To file, during any period in which offers or sales are being
     made, a post-effective amendment to this registration statement;
 
             (i) To include any prospectus required by Section 10(a)(3) of the
        Securities Act of 1933;
 
             (ii) To reflect in the prospectus any facts or events arising after
        the effective date of the registration statement (or the most recent
        post-effective amendment thereof) which, individually or in the
        aggregate, represent a fundamental change in the information set forth
        in the registration statement. Notwithstanding the foregoing, any
        increase or decrease in volume of securities offered (if the total
        dollar value of securities offered would not exceed that which was
        registered) and any deviation from the low or high and of the estimated
        maximum offering range may be reflected in the form of prospectus filed
        with the Commission pursuant to Rule 424(b) if, in the aggregate, the
        changes in volume and price represent no more than 20 percent change in
        the maximum aggregate offering price set forth in the "Calculation of
        Registration Fee" table in the effective registration statement.
 
             (iii) To include any material information with respect to the plan
        of distribution not previously disclosed in the registration statement
        or any material change to such information in the registration
        statement.
 
          (2) That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.
 
          (3) To remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.
 
          (4) That, for purposes of determining any liability under the
     Securities Act of 1933, each filing of the Registrant's annual report
     pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934
     (and, where applicable, each filing of an employee benefit plan's annual
     report pursuant to Section 15(d) of the Securities Exchange Act of 1934)
     that is incorporated by reference in the registration statement shall be
     deemed to be a new registration statement relating to the securities
     offered therein, and the offering of such securities at that time shall be
     deemed to be the initial bona fide offering thereof.
 
          (5) Insofar as indemnification for liabilities arising under the
     Securities Act of 1933 may be permitted to directors, officers and
     controlling persons of the Registrant pursuant to the foregoing provisions,
     or otherwise, the Registrant has been advised that in the opinion of the
     Securities and Exchange Commission such indemnification is against public
     policy as expressed in the Act and is, therefore, unenforceable. In the
     event that a claim for indemnification against such liabilities (other than
     the payment by the registrant of expenses incurred or paid by a director,
     officer or controlling person of the registrant in the successful defense
     of any action, suit or proceeding) is asserted by such director, officer or
     controlling person in connection with the securities being registered, the
     Registrant will, unless in the opinion of its counsel the matter has been
     settled by controlling precedent, submit to a court of appropriate
     jurisdiction the question whether such indemnification by it is against
     public policy as expressed in the Act and will be governed by the final
     adjudication of such issue.
 
                                        3
   5
 
                                   SIGNATURES
 
     Pursuant to the requirements of the Securities Act of 1933, as amended, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing this Post-Effective Amendment No. 1 on Form S-8
to the Registration Statement on Form S-4 (Registration No. 33-59949) and has
duly caused this Post-Effective Amendment on Form S-8 to such Registration
Statement on Form S-4 to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of South San Francisco, State of California, on
October 25, 1995.
 
                                          GENENTECH, INC.
 
                                          By:  /s/  LOUIS J. LAVIGNE, JR.
                                          --------------------------------------
                                                  Louis J. Lavigne, Jr.
                                             Senior Vice President and Chief
                                                    Financial Officer
                                              (Principal Financial Officer)
 

                                            
PRINCIPAL EXECUTIVE OFFICER:

           /s/  ARTHUR D. LEVINSON                 President and Chief Executive Officer
- - ---------------------------------------------
             Arthur D. Levinson

PRINCIPAL FINANCIAL OFFICER:

         /s/  LOUIS J. LAVIGNE, JR.              Senior Vice President and Chief Financial
- - ---------------------------------------------                     Officer
            Louis J. Lavigne, Jr.

PRINCIPAL ACCOUNTING OFFICER:

          /s/  BRADFORD S. GOODWIN                     Vice President and Controller
- - ---------------------------------------------
             Bradford S. Goodwin

DIRECTORS:
           /s/  ARTHUR D. LEVINSON
- - ---------------------------------------------
             Arthur D. Levinson

           /s/  HERBERT W. BOYER*
- - ---------------------------------------------
              Herbert W. Boyer

             /s/   JURGEN DREWS*
- - ---------------------------------------------
                Jurgen Drews

            /s/   FRANZ B. HUMER*
- - ---------------------------------------------
               Franz B. Humer

 
                                        4
   6
 

                                            
          /s/   LINDA F. LEVINSON*
- - ---------------------------------------------
              Linda F. Levinson

           /s/   J. RICHARD MUNRO*
- - ---------------------------------------------
              J. Richard Munro

           /s/   DONALD L. MURFIN*
- - ---------------------------------------------
              Donald L. Murfin

          /s/   JOHN T. POTTS, JR.*
- - ---------------------------------------------
             John T. Potts, Jr.

         /s/   C. THOMAS SMITH, JR.*
- - ---------------------------------------------
            C. Thomas Smith, Jr.

          /s/   ROBERT A. SWANSON*
- - ---------------------------------------------
              Robert A. Swanson

         /s/   DAVID S. TAPPAN, JR.*
- - ---------------------------------------------
            David S. Tappan, Jr.

        *By: /s/  JOHN P. MCLAUGHLIN
- - ---------------------------------------------
              Attorney-in-Fact
              October 25, 1995

 
                                        5
   7
 
                               INDEX TO EXHIBITS
 


EXHIBIT
NUMBER                                                                                  PAGE
- - -------                                                                                 ----
                                                                                  
  5-A(1)  Opinion of Counsel..........................................................
 15-A(1)  Letter re: unaudited financial information..................................
 23-A(1)  Consent of Ernst & Young LLP, independent auditors..........................
 23-B(1)  Consent of Counsel is contained in Exhibit 5-A(1) to this Registration
            Statement.................................................................
 25-A(1)  Power of Attorney is contained on the signature pages to this Registration
            Statement.................................................................
 99-A(1)  1991 Employee Stock Plan, as amended and restated as of October 25, 1995....