1 FORM 10-K/A NO.2 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 (Mark One) /X/ Annual Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the fiscal year ended September 30, 1997 or / / Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission file number 0-15190 OSI Pharmaceuticals, Inc. (Exact name of Registrant as specified in its charter) Delaware 13-3159796 (State or other jurisdiction of (I.R.S. Employer incorporation or organization) Identification No.) 106 Charles Lindbergh Blvd., Uniondale, N.Y. 11553 (Address of principal executive offices) (Zip Code) Registrant's telephone number, including area code (516) 222-0023 SECURITIES REGISTERED PURSUANT TO SECTION 12(B) OF THE ACT: Title of each class Name of each exchange on which registered None None SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE ACT: Common Stock, par value $.01 per share (Title of Class) Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes /X/ No / / Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of Registrant's knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. / / As of November 28, 1997, the aggregate market value of the Registrant's voting stock held by non-affiliates was $133,215,769. For purposes of this calculation, shares of Common Stock held by directors, officers and stockholders whose ownership exceeds five percent of the Common Stock outstanding at November 28, 1997 were excluded. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant. As of November 28, 1997, there were 22,263,969 shares of the Registrant's $.01 par value common stock outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the Registrant's definitive proxy statement for its 1998 annual meeting of stockholders are incorporated by reference into Part III. 2 SIGNATURE Pursuant to the requirements of Section 13 or 15(d) of the Securities and Exchange Act of 1934, the Company has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized. OSI PHARMACEUTICALS, INC. By: /s/ Robert L. Van Nostrand -------------------------- Robert L. Van Nostrand Chief Financial Officer Date: April 9, 1998 -2- 3 INDEX TO EXHIBITS Exhibits 3.1 Certificate of Incorporation, as amended (1) 3.2 Bylaws, as amended (1) 10.1 1985 Stock Option Plan (filed as an exhibit to the Company's registration statement on Form S-1 (file no. 33-3148) and incorporated herein by reference) 10.2 1989 Incentive and Non-Qualified Stock Option Plan (filed as an exhibit to the Company's registration statement on Form S-8 (file no. 33-38443) and incorporated herein by reference) 10.3 1993 Incentive and Non-Qualified Stock Option Plan, as amended (filed as an exhibit to the Company's registration statement on Form S-8 (file no. 33-64713) and incorporated herein by reference) 10.4 Stock Purchase Plan for Non-Employee Directors (filed as an exhibit to the Company's registration statement on Form S-8 (file no. 333-06861) and incorporated herein by reference) 10.5 1995 Employee Stock Purchase Plan (filed as an exhibit to the Company's registration statement on Form S-8 (file no. 333-06861) and incorporated herein by reference) 10.6 1997 Incentive and Non-Qualified Stock Option Plan (filed as an exhibit to the Company's registration statement on Form S-8 (file no. 333-39509) and incorporated herein by reference) 10.7+ Collaborative Research Agreement dated April 1, 1996 between the Company and Pfizer Inc. (2) 10.8+ License Agreement dated April 1, 1996 between the Company and Pfizer Inc. (2) 10.9+ Stockholders' Agreement dated April 23, 1996 among Anaderm Research Corp., the Company, Pfizer Inc., New York University and certain individuals (2) 10.10+ Collaborative Research Agreement dated April 23,1996 amount the Company, Pfizer Inc. and Anaderm Research Corp. (2) 10.11 Registration Rights Agreement dated April 11, 1996 among the Company and the former stockholders of MYCOsearch, Inc. and their designees (2) -3- 4 10.12 Form of Warrants issued by the Company to the former stockholders of MYCOsearch, Inc. and their designees covering an aggregate of 100,000 shares of common stock (2) 10.13 Employment Agreement dated April 11, 1996 between the Company and Dr. Barry Katz (2) 10.14+ Collaborative Research Agreement dated as of December 31, 1991 between the Company and American Home Products Corporation (3) 10.15+ Amendatory Agreement dated as of December 31, 1993 between the Company and American Home Products Corporation (3) 10.16** Common Stock Purchase Warrant granted to Marion Merrell Dow, Inc. dated December 11, 1992 10.17 Collaborative Agreement dated as of April 19, 1995 between the Company and Novartis Pharma AG (4) 10.18 Letter Agreement dated as of April 19, 1995 between the Company and Novartis Pharma AG (4) 10.19 Registration Rights Agreement dated as of April 19, 1995 between the Company and Novartis Pharma AG (4) 10.20 Asset Purchase Agreement dated June 26, 1995 among the Company, Calbiochem-Novabiochem International, Inc. and Calbiochem-Novabiochem Corporation (5) 10.21 New Product License Right of First Refusal Agreement dated August 2, 1995 between the Company and Calbiochem-Novabiochem Corporation (5) 10.22 Employment Agreement dated as of February 9, 1990 between the Company and Gary E. Frashier (6) 10.23 Form of Employment Agreement dated as of August 27, 1991, which is substantially identical in all material respects to the Employment Agreement dated as of April 28, 1993 between the Company and Colin Goddard, Ph.D. (6) 10.24+ Agreement dated September 27, 1996 between the Company and Becton, Dickinson and Company (6) 10.25+ Collaborative Research and License Agreement dated as of January 1, 1997 between the Company and Bayer Corporation (7) 10.26+ Collaborative Research, Development and Commercialization Agreement dated as of May 1, 1996 between the Company and BioChem Pharma (International) Inc. (7) -4- 5 10.27+ EPO Collaborative Research and License Agreement dated as of January 1, 1997 between the Company and Hoechst Marion Roussel, Inc. (8) 10.28+ Collaborative Research, Development and License Agreement dated as of February 12, 1997 by and among the Company, Sankyo Company, Ltd., and MRC Collaborative Center (8) 10.29+ Collaborative Research, Development and Commercialization Agreement dated as of March 7, 1997 between the Company and Sepracor, Inc. (8) 10.30+ License Agreement dated as of March 18, 1997 between the Company and The Dow Chemical Company (8) 10.31 Amended and Restated Collaborative Research and License Agreement effective as of April 1, 1997 by and among the Company, Hoechst Marion Roussel, Inc. and Hoechst Aktiengesellschaft (9) 10.32**+ Stock Subscription Agreement dated as of July 17, 1997 by and between the Company and Helicon Therapeutics, Inc. 10.33*+ License and Services Agreement dated as of July 17, 1997 by and between the Company and Helicon Therapeutics, Inc. 10.34*+ Stockholders' Agreement dated as of July 17, 1997 by and among Helicon Therapeutics, Inc. and certain stockholders of Helicon Therapeutics, Inc. 10.35*+ Convertible Preferred Stock Purchase Agreement dated as of July 17, 1997 by and among Helicon Therapeutics, Inc., the Company, Hoffman-La Roche, Inc. and Cold Spring Harbor Laboratory. 10.36**+ Collaborative Research and License Agreement effective as of July 1, 1997 by and between Hoffman-La Roche, Inc. and Helicon Therapeutics, Inc. 21** Subsidiaries of the Company 23** Consent of KPMG Peat Marwick, LLP, independent public accountants 27** Financial Data Schedule 99** Additional Exhibits: Risk Factors - ------------------------------------ * Filed herewith. ** Previously filed. -5- 6 + Portions of this exhibit have been redacted and are subject to a confidential treatment request filed with the Secretary of the Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended. (1) Filed as an exhibit to the Company's registration statement on Form S-3 (file no. 333-937) and incorporated herein by reference. (2) Filed as an exhibit to the Company's quarterly report on Form 10-Q for the fiscal quarter ended March 31, 1996, as amended, and incorporated herein by reference. (3) Filed as an exhibit to the Company's quarterly report on Form 10-Q for the fiscal quarter ended December 31, 1995, as amended, and incorporated herein by reference. (4) Filed as an exhibit to the Company's annual report on Form 10-K for the fiscal year ended September 30, 1995, as amended, and incorporated herein by reference. (5) Filed as an exhibit to the Company's current report on Form 8-K dated August 2, 1995 and incorporated herein by reference. (6) Filed as an exhibit to the Company's annual report on Form 10-K for the fiscal year ended September 30, 1996 and incorporated herein by reference. (7) Filed as an exhibit to the Company's quarterly report on Form 10-Q for the fiscal quarter ended December 31, 1996 and incorporated herein by reference. (8) Filed as an exhibit to the Company's quarterly report on Form 10-Q for the fiscal quarter ended March 31, 1997 and incorporated herein by reference. (9) Filed as an exhibit to the Company's quarterly report on Form 10-Q for the fiscal quarter ended June 30, 1997 and incorporated herein by reference. -6-