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                                                                     EXHIBIT 4.3

NEITHER THIS WARRANT NOR THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE BEEN 
REGISTERED WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION (THE 
"COMMISSION") OR THE SECURITIES COMMISSION OF ANY STATE PURSUANT TO AN 
EXEMPTION FROM REGISTRATION UNDER REGULATION D PROMULGATED UNDER THE SECURITIES 
ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"). THIS WARRANT SHALL NOT 
CONSTITUTE AN OFFER TO SELL NOR A SOLICITATION OF AN OFFER TO BUY THE WARRANT 
OR THE SHARES ISSUABLE UPON EXERCISE HEREOF IN ANY JURISDICTION IN WHICH SUCH 
OFFER OR SOLICITATION WOULD BE UNLAWFUL.

NEITHER THIS WARRANT NOR THE SHARES ISSUABLE UPON EXERCISE HEREOF MAY BE SOLD, 
PLEDGED, TRANSFERRED OR ASSIGNED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION 
STATEMENT UNDER THE SECURITIES ACT AND UNDER APPLICABLE STATE SECURITIES LAWS, 
OR IN A TRANSACTION WHICH IS EXEMPT FROM REGISTRATION UNDER THE PROVISIONS OF 
THE SECURITIES ACT AND UNDER PROVISIONS OF APPLICABLE STATE SECURITIES LAWS; 
AND IN THE CASE OF AN EXEMPTION, ONLY IF THE COMPANY HAS RECEIVED AN OPINION OF 
COUNSEL THAT SUCH TRANSACTION DOES NOT REQUIRE REGISTRATION OF THE WARRANT OR 
SUCH SHARES, WHICH OPINION AND WHICH COUNSEL SHALL BE SATISFACTORY TO THE 
COMPANY IN ITS SOLE DISCRETION.

                             STOCK PURCHASE WARRANT
                                        
                  To Purchase        Shares of Common Stock of
                                        
                       INTEGRATED SURGICAL SYSTEMS, INC.

         THIS CERTIFIES that, for value received,                      (the 
"Holder"), is entitled, upon the terms and subject to the conditions 
hereinafter set forth, at any time on or after March 4, 1999 and on or prior 
to March 3, 2002 (the "Termination Date") but not thereafter, to subscribe for 
and purchase from INTEGRATED SURGICAL SYSTEMS, INC., a corporation incorporated 
in Delaware (the "Company"),                                  (      ) shares 
(the "Warrant Shares") of Common Stock, par value US $0.01 per share of the 
Company (the "Common Stock"). The purchase price of one share of Common Stock 
(the "Exercise Price") under this Warrant shall be equal to One Hundred Thirty 
(130%) percent of the Market Price on the Closing Date (as those terms are 
defined in the Preferred Stock Purchase Agreement dated as of August 25, 1998 
("Agreement"), between the Company and the Holder), as reported by Bloomberg, 
L.P. The Exercise Price and the number of shares for which the Warrant is 
exercisable shall be subject to adjustment as provided herein. This Warrant is 
being issued in connection with the Agreement and is subject to its terms and 
conditions. In the event of any conflict between the terms of this Warrant and 
the Agreement, the Agreement shall control.
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         1.  Title of Warrant. Prior to the expiration hereof and subject to
compliance with applicable laws, this Warrant and all rights hereunder are
transferable, in whole or in part, at the office or agency of the Company by the
holder hereof in person or by duly authorized attorney, upon surrender of this
Warrant together with the Assignment Form annexed hereto properly endorsed.

         2.  Authorization of Shares. The Company covenants that all shares of
Common Stock which may be issued upon the exercise of rights represented by this
Warrant will, upon exercise of the rights represented by this Warrant, be duly
authorized, validly issued, fully paid and nonassessable and free from all
taxes, liens and charges in respect of the issue thereof (other than taxes in
respect of any transfer occurring contemporaneously with such issue).

         3.  Exercise of Warrant. (a) Except as provided in Section 4 herein,
exercise of the purchase rights represented by this Warrant may be made at any
time or times, before the close of business on the Termination Date, or such
earlier date on which this Warrant may terminate as provided in this Warrant, by
the surrender of this Warrant and the Notice of Exercise Form annexed hereto
duly executed, at the office of the Company (or such other office or agency of
the Company as it may designate by notice in writing to the registered holder
hereof at the address of such holder appearing on the books of the Company) and
upon payment of the Exercise Price of the shares thereby purchased by cash,
check or bank draft payable to the Company or by wire transfer or cashier's
check drawn on a United States bank; whereupon the holder of this Warrant shall
be entitled to receive a certificate for the number of shares of Common Stock so
purchased. Certificates for shares purchased hereunder shall be delivered to the
holder hereof within three (3) business days after the date on which this
Warrant shall have been exercised as aforesaid. Payment of the Exercise Price of
the shares may be by certified check or cashier's check or by wire transfer to
an account designated by the Company in an amount equal to the Exercise Price
multiplied by the number of Warrant Shares. This Warrant shall be deemed to have
been exercised and such certificate or certificates shall be deemed to have been
issued, and Holder or any other person so designated to be named therein shall
be deemed to have become a holder of record of such shares for all purposes, as
of the date the Warrant has been exercised by payment to the Company of the
Warrant purchase price and all taxes required to be paid by Holder, if any,
pursuant to Section 5 prior to the issuance of such shares have been paid. If
this Warrant shall have been exercised in part, the Company shall, at the time
of delivery of the certificate or certificates representing Warrant Shares,
deliver to Holder a new Warrant evidencing the rights of Holder to purchase the
unpurchased shares of Common Stock called for by this Warrant, which new Warrant
shall in all other respects be identical with this Warrant.

         (b)  The holder shall be entitled to exercise the Warrant
notwithstanding the commencement of any case under 11 U.S.C. Section 101 et seq.
(the "Bankruptcy Code"). In the event the Company is a debtor under the
Bankruptcy Code, the Company hereby waives to the fullest extent permitted any
rights to relief it may have under 11 U.S.C. Section 362 in respect of the
Holder's exercise right. The Company hereby waives to the fullest extent
permitted any rights to relief it may have under 11 U.S.C. Section 362 in
respect of the exercise of the Warrant. The Company agrees, without cost or
expense to the Holder, to take or consent to any and all action necessary to
effectuate relief under 11 U.S.C. Section 362.


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         4. No Fractional Shares or Scrip. No fractional shares or scrip
representing fractional shares shall be issued upon the exercise of this
Warrant. As to any fraction of a share which Holder would otherwise be entitled
to purchase upon such exercise, the Company shall pay a cash adjustment in
respect of such final fraction in an amount equal to the same fraction of the
Market Price per share of Common Stock as of the Closing Date.


         5. Charges, Taxes and Expenses. Issuance of certificates for shares of
Common Stock upon the exercise of this Warrant shall be made without charge to
the holder hereof for any issue or transfer tax or other incidental expense in
respect of the issuance of such certificate, all of which taxes and expenses
shall be paid by the Company, and such certificates shall be issued in the name
of the holder of this Warrant or in such name or names as may be directed by the
holder of this Warrant; provided, however, that in the event certificates for
shares of Common Stock are to be issued in a name other than the name of the
holder of this Warrant, this Warrant when surrendered for exercise shall be
accompanied by the Assignment Form attached hereto duly executed by the holder
hereof; and provided further, that upon any transfer involved in the issuance or
delivery of any certificates for shares of Common Stock, the Company may
require, as a condition thereto, the payment of a sum sufficient to reimburse it
for any transfer tax incidental thereto.


         6. Closing of Books. The Company will not close its shareholder books
or records in any manner which prevents the timely exercise of this Warrant.


         7. Transfer, Division and Combination. (a) Subject to compliance with
any applicable securities laws, transfer of this Warrant and all rights
hereunder, in whole or in part, shall be registered on the books of the Company
to be maintained for such purpose, upon surrender of this Warrant at the
principal office of the Company, together with a written assignment of this
Warrant substantially in the form attached hereto duly executed by Holder or its
agent or attorney and funds sufficient to pay any transfer taxes payable upon
the making of such transfer. Upon such surrender and, if required, such payment,
the Company shall execute and deliver a new Warrant or Warrants in the name of
the assignee or assignees and in the denomination specified in such instrument
of assignment, and shall issue to the assignor a new Warrant evidencing the
portion of this Warrant not so assigned, and this Warrant shall promptly be
cancelled. A Warrant, if properly assigned, may be exercised by a new Holder for
the purchase of shares of Common Stock without having a new Warrant issued.


        (b) This Warrant may be divided or combined with other Warrants upon 
presentation hereof at the aforesaid office of the Company, together with a 
written notice specifying the names and denominations in which new Warrants are 
to be issued, signed by Holder or its agent or attorney. Subject to compliance 
with Section 7(a), as to any transfer which may be involved in such division or 
combination, the Company shall execute and deliver a new Warrant or Warrants in 
exchange for the Warrant or Warrants to be divided or combined in accordance 
with such notice.
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        (c) The Company shall prepare, issue and deliver at its own expense 
(other than transfer taxes) the new Warrant or Warrants under this Section 7.


        (d) The Company agrees to maintain, at its aforesaid office, books for 
the registration and the registration of transfer of the Warrants.


     8. No Rights as Shareholder until Exercise. This Warrant does not entitle 
the holder hereof to any voting rights or other rights as a shareholder of the 
Company prior to the exercise thereof. Upon the surrender of this Warrant and 
the payment of the aggregate Exercise Price, the Warrant Shares so purchased 
shall be and be deemed to be issued to such holder as the record owner of such 
shares as of the close of business on the later of the date of such surrender 
or payment.


     9. Loss, Theft, Destruction or Mutilation of Warrant. The Company 
represents and warrants that upon receipt by the Company of evidence reasonably 
satisfactory to it of the loss, theft, destruction or mutilation of this 
Warrant certificate or any stock certificate relating to the Warrant Shares, 
and in case of loss, theft or destruction, of indemnity or security reasonably 
satisfactory to it, and upon surrender and cancellation of such Warrant or 
stock certificate, if mutilated, the Company will make and deliver a new 
Warrant or stock certificate of like tenor and dated as of such cancellation, 
in lieu of such Warrant or stock certificate.


     10. Saturdays, Sundays, Holidays, etc. If the last or appointed day for 
the taking of any action or the expiration of any right required or granted 
herein shall be a Saturday, Sunday or a legal holiday, then such action may be 
taken or such right may be exercised on the next succeeding day not a Saturday, 
Sunday or legal holiday.


     11. (a) Adjustments of Exercise Price and Number of Warrant Shares. The 
number and kind of securities purchasable upon the exercise of this Warrant and 
the Exercise Price shall be subject to adjustment from time to time upon the 
happening of any of the following. In case the Company shall (i) declare or pay 
a dividend in shares of Common Stock or make a distribution in shares of Common 
Stock to holders of its outstanding Common Stock, (ii) subdivide its 
outstanding shares of Common Stock, (iii) combine its outstanding shares of 
Common Stock into a smaller number of shares of Common Stock or (iv) issue any 
shares of its capital stock in a reclassification of the Common Stock, then the 
number of Warrant Shares purchasable upon exercise of this Warrant immediately 
prior thereto shall be adjusted so that the holder of this Warrant shall be 
entitled to receive the kind and number of Warrant Shares or other securities 
of the Company which he would have owned or have been entitled to receive had 
such Warrant been exercised in advance thereof. Upon each such adjustment of 
the kind and number of Warrant Shares or other securities of the Company which 
are purchasable hereunder, the holder of this Warrant shall thereafter be 
entitled to purchase the number of Warrant Shares or other securities resulting 
from such adjustment at an Exercise Price per such Warrant Share or other 
security obtained by multiplying the Exercise Price in effect immediately prior 
to such adjustment by the number of Warrant Shares purchasable pursuant hereto 
immediately prior to such adjustment and dividing by the number of Warrant 
Shares or other securities of the Company resulting from such adjustment. An 
adjustment made pursuant to this paragraph shall become effective immediately 
after the effective date of such event retroactive to the record date, if any, 
for such event.

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          (b)  Reorganization, Reclassification, Merger, Consolidation or 
Disposition of Assets.  In case the Company shall reorganize its capital, 
reclassify its capital stock, consolidate or merge with or into another 
corporation (where the Company is not the surviving corporation or where there 
is a change in or distribution with respect to the Common Stock of the 
Company), or sell, transfer or otherwise dispose of all or substantially all 
its property, assets or business to another corporation and, pursuant to the 
terms of such reorganization, reclassification, merger, consolidation or 
disposition of assets, shares of common stock of the successor or acquiring 
corporation, or any cash, shares of stock or other securities or property of 
any nature whatsoever (including warrants or other subscription or purchase 
rights) in addition to or in lieu of common stock of the successor or 
acquiring corporation ("Other Property"), are to be received by or distributed 
to the holders of Common Stock of the Company, then Holder shall have the right 
thereafter to receive, upon exercise of the Warrant, the number of shares of 
common stock of the successor or acquiring corporation or of the Company, if it 
is the surviving corporation, and Other Property receivable upon or as a result 
of such reorganization, reclassification, merger, consolidation or disposition 
of assets by a holder of the number of shares of Common Stock for which this 
Warrant is exercisable immediately prior to such event. In case of any such 
reorganization, reclassification, merger, consolidation or disposition of 
assets, the successor or acquiring corporation (if other than the Company) 
shall expressly assume the due and punctual observance and performance of each 
and every covenant and condition of this Warrant to be performed and observed 
by the Company and all the obligations and liabilities hereunder, subject to 
such modifications as may be deemed appropriate (as determined by resolution of 
the Board of Directors of the Company) in order to provide for adjustments of 
shares of Common Stock for which this Warrant is exercisable which shall be as 
nearly equivalent as practicable to the adjustments provided for in this 
Section 11. For purposes of this Section 11, "common stock of the successor or 
acquiring corporation" shall include stock of such corporation of any class 
which is not preferred as to dividends or assets over any other class of stock 
of such corporation and which is not subject to redemption and shall also 
include any evidences of indebtedness, shares of stock or other securities 
which are convertible into or exchangeable for any such stock, either 
immediately or upon the arrival of a specified date or the happening of a 
specified event and any warrants or other rights to subscribe for or purchase 
any such stock. The foregoing provisions of this Section 11 shall similarly 
apply to successive reorganizations, reclassifications, mergers, consolidations 
or disposition of assets.

          (c)  Certain Limitations. Notwithstanding anything herein to the 
contrary, the Company agrees not to enter into any transaction which, by reason 
of any adjustment hereunder, would cause the Exercise Price to be less than the 
par value per share of Common Stock.

     12.  Voluntary Adjustment by the Company. The Company may at any time 
during the term of this Warrant, reduce the then current Exercise Price to any 
amount and for any period of time deemed appropriate by the Board of Directors 
of the Company.

     13.  Notice of Adjustment. Whenever the number of Warrant Shares or number 
or kind of securities or other property purchasable upon the exercise of this 
Warrant or the Exercise Price is adjusted, as herein provided, the Company 
shall promptly mail by registered or certified mail, return receipt requested, 
to the holder of this Warrant notice of such adjustment or adjustments setting 
forth the number of Warrant Shares (and other securities or property)


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purchasable upon the exercise of this Warrant and the Exercise Price of such
Warrant Shares (and other securities or property) after such adjustment, setting
forth a brief statement of the facts requiring such adjustment and setting forth
the computation by which such adjustment was made. Such notice, in absence of
manifest error, shall be conclusive evidence of the correctness of such
adjustment.

     14.  Notice of Corporate Action. If at any time

          (a) the Company shall take a record of the holders of its Common Stock
for the purpose of entitling them to receive a dividend or other distribution,
or any right to subscribe for or purchase any evidences of its indebtedness, any
shares of stock of any class or any other securities or property, or to receive
any other right, or

          (b) there shall be any capital reorganization of the Company, any
reclassification or recapitalization of the capital stock of the Company or any
consolidation or merger of the Company with, or any sale, transfer or other
disposition of all or substantially all the property, assets or business of the
Company to, another corporation or,

          (c) there shall be a voluntary or involuntary dissolution, liquidation
or winding up of the Company;

then, in any one or more of such cases, the Company shall give to Holder (i) at
least 30 days' prior written notice of the date on which a record date shall be
selected for such dividend, distribution or right or for determining rights to
vote in respect of any such reorganization, reclassification, merger,
consolidation, sale, transfer, disposition, liquidation or winding up, and (ii)
in the case of any such reorganization, reclassification, merger, consolidation,
sale, transfer, disposition, dissolution, liquidation or winding up, at least 30
days' prior written notice of the date when the same shall take place. Such
notice in accordance with the foregoing clause also shall specify (i) the date
on which any such record is to be taken for the purpose of such dividend,
distribution or right, the date on which the holders of Common Stock shall be
entitled to any such dividend, distribution or right, and the amount and
character thereof, and (ii) the date on which any such reorganization,
reclassification, merger, consolidation, sale, transfer, disposition,
dissolution, liquidation or winding up is to take place and the time, if any
such time is to be fixed, as of which the holders of Common Stock shall be
entitled to exchange their shares of Common Stock for securities or other
property deliverable upon such disposition, dissolution, liquidation or winding
up. Each such written notice shall be sufficiently given if addressed to Holder
at the last address of Holder appearing on the books of the Company and
delivered in accordance with Section 17(d).

     15.  Authorized Shares. The Company covenants that during the period the
Warrant is outstanding, it will reserve from its authorized and unissued Common
Stock a sufficient number of shares to provide for the issuance of the Warrant
Shares upon the exercise of any purchase rights under this Warrant. The Company
further covenants that its issuance of this Warrant shall constitute full
authority to its officers who are charged with the duty of executing stock
certificates to execute and issue the necessary certificates for the Warrant
Shares upon the exercise of the purchase rights under this Warrant. The Company
will take all such reasonable action as may be necessary to assure that such
Warrant Shares may be issued as

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provided herein without violation of any applicable law or regulation, or of any
requirements of NASDAQ or any domestic securities exchange upon which the Common
Stock may be listed.

          The Company shall not by any action, including, without limitation, 
amending its certificate of incorporation or through any reorganization, 
transfer of assets, consolidation, merger, dissolution, issue or sale of 
securities or any other voluntary action, avoid or seek to avoid the observance 
or performance of any of the terms of this Warrant, but will at all times in 
good faith assist in the carrying out of all such terms and in the taking of all
such actions as may be necessary or appropriate to protect the rights of Holder 
against impairment. Without limiting the generality of the foregoing, the 
Company will (a) not increase the par value of any shares of Common Stock 
receivable upon the exercise of this Warrant above the amount payable therefor 
upon such exercise immediately prior to such increase in par value, (b) take 
all such action as may be necessary or appropriate in order that the Company 
may validly and legally issue fully paid and nonassessable shares of Common 
Stock upon the exercise of this Warrant, and (c) use its best efforts to obtain 
all such authorizations, exemptions or consents from any public regulatory body 
having jurisdiction thereof as may be necessary to enable the Company to 
perform its obligations under this Warrant.

          Upon the request of Holder, the Company will at any time during the 
period this Warrant is outstanding acknowledge in writing, in form reasonably 
satisfactory to Holder, the continuing validity of this Warrant and the 
obligations of the Company hereunder.

          Before taking any action which would cause an adjustment reducing the 
current Exercise Price below the then par value, if any, of the shares of 
Common Stock issuable upon exercise of the Warrants, the Company shall take any 
corporate action which may be necessary in order that the Company may validly 
and legally issue fully paid and non-assessable shares of such Common Stock at 
such adjusted Exercise Price.

          Before taking any action which would result in an adjustment in the
number of shares of Common Stock for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions
thereof, or consents thereto, as may be necessary from any public regulatory
body or bodies having jurisdiction thereof.

     16.  Required Registration. Pursuant to the terms and conditions set forth
in the Registration Rights Agreement entered into between the Company and the
Holders as of the date of issuance of this Warrant, the Company shall prepare
and file with the Commission not later than the 45th day after the Closing Date,
a Registration Statement relating to the offer and sale of the Common Stock
issuable upon exercise of the Warrants and shall use its best efforts to cause
the Commission to declare such Registration Statement effective under the
Securities Act as promptly as practicable but no later than 90 days after the
closing date (or 120 days after the Closing Date if such Registration Statement
is not permitted to be filed on Form S-3).

     17.  Miscellaneous.

          (a)  Issue Date; Jurisdiction. The provisions of this Warrant shall be
construed and shall be given effect in all respects as if it had been issued and
delivered by the    


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Company on the date hereof. This Warrant shall be binding upon any successors 
or assigns of the Company. This Warrant shall constitute a contract under the 
laws of New York without regard to its conflict of law, principles or rules, 
and be subject to arbitration pursuant to the terms set forth in the Agreement.

          (b)  Restrictions. The holder hereof acknowledges that the Warrant 
Shares acquired upon the exercise of this Warrant, if not registered, will have 
restrictions upon resale imposed by state and federal securities laws.

          (c)  Nonwaiver and Expenses. No course of dealing or any delay or 
failure to exercise any right hereunder on the part of Holder shall operate as 
a waiver of such right or otherwise prejudice Holder's rights, powers or 
remedies, notwithstanding all rights hereunder terminate on the Termination 
Date. If the Company fails to make, when due, any payments provided for 
hereunder, or fails to comply with any other provision of this Warrant, the 
Company shall pay to Holder such amounts as shall be sufficient to cover any 
costs and expenses including, but not limited to, reasonable attorneys' fees, 
including those of appellate proceedings, incurred by Holder in collecting any 
amounts due pursuant hereto or in otherwise enforcing any of its rights, powers 
or remedies hereunder.

          (d)  Notices. Any notice, request or other document required or 
permitted to be given or delivered to the holder hereof by the Company shall be 
delivered in accordance with the notice provisions of the Agreement.

          (e)  Limitation of Liability. No provision hereof, in the absence of 
affirmative action by Holder to purchase shares of Common Stock, and no 
enumeration herein of the rights or privileges of Holder hereof, shall give 
rise to any liability of Holder for the purchase price of any Common Stock or 
as a stockholder of the Company, whether such liability is asserted by the 
Company or by creditors of the Company.

          (f)  Remedies. Holder, in addition to being entitled to exercise all 
rights granted by law, including recovery of damages, will be entitled to 
specific performance of its rights under this Warrant. The Company agrees that 
monetary damages would not be adequate compensation for any loss incurred by 
reason of a breach by it of the provisions of this Warrant and hereby agrees to 
waive the defense in any action for specific performance that a remedy at law 
would be adequate.

          (g)  Successors and Assigns. Subject to applicable securities laws, 
this Warrant and the rights evidenced hereby shall inure to the benefit of and 
be binding upon the successors of the Company and the successors and assigns of 
Holder. The provisions of this Warrant are intended to be for the benefit of 
all Holders from time to time of this Warrant and shall be enforceable by any 
such Holder or holder of Warrant Stock.

          (h)  Cooperation. The Company shall cooperate with Holder in supplying
such information as may be reasonably necessary for Holder to complete and file
any information reporting forms presently or hereafter required by the
Commission as a condition to the availability of an exemption from the
Securities Act for the sale of any Warrant or Restricted Common Stock.

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          (i) Indemnification. The Company agrees to indemnify and hold harmless
Holder from and against any liabilities, obligations, losses, damages,
penalties, actions, judgments, suits, claims, costs, attorneys' fees, expenses
and disbursements of any kind which may be imposed upon, incurred by or asserted
against Holder in any manner relating to or arising out of any failure by the
Company to perform or observe in any material respect any of its covenants,
agreements, undertakings or obligations set forth in this Warrant; provided,
however, that the Company will not be liable hereunder to the extent that any
liabilities, obligations, losses, damages, penalties, actions, judgments, suits,
claims, costs, attorneys' fees, expenses or disbursements are found in a final
non-appealable judgment by a court to have resulted from Holder's negligence,
bad faith or willful misconduct in its capacity as a stockholder or
warrantholder of the Company.

          (j) Amendment. This Warrant and all other Warrants may be modified or
amended or the provisions hereof waived with the written consent of the Company
and the Holder.

          (k) Severability. Wherever possible, each provision of this Warrant
shall be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Warrant shall be prohibited by or
invalid under applicable law, such provision shall be ineffective to the extent
of such prohibition or invalidity, without invalidating the remainder of such
provisions or the remaining provisions of this Warrant.

          (l) Headings. The headings used in this Warrant are for the
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

     IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by
its officer thereunto duly authorized.


Dated: September 10, 1998

                                           INTEGRATED SURGICAL SYSTEMS, INC.



                                           By: Ramesh C. Trivedi  
                                               _________________________________
                                               CFO, Authorized Signatory



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                               NOTICE OF EXERCISE


To:    INTEGRATED SURGICAL SYSTEMS, INC.


     (1) The undersigned hereby elects to purchase         shares of Common 
Stock, par value $0.01 per share (the "Common Stock"), of INTEGRATED SURGICAL 
SYSTEMS, INC. pursuant to the terms of the attached Warrant, and tenders 
herewith payment of the exercise price in full, together with all applicable 
transfer taxes, if any.


     (2) Please issue a certificate or certificates representing said shares of 
Common Stock in the name of the undersigned or in such other name as is 
specified below:


                        ------------------------------------
                        (Name)


                        ------------------------------------
                        (Address)


                        ------------------------------------


Dated:


                                                 -------------------------------
                                                 Signature
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                                ASSIGNMENT FORM


                   (To assign the foregoing warrant, execute
                   this form and supply required information.
                 Do not use this form to exercise the warrant.) 


          FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced 
thereby are hereby assigned to


- ------------------------------------------------------------- whose address is

- -------------------------------------------------------------------------------.


- --------------------------------------------------------------------------------

                                                         Dated: ---------------,


                               Holder's Signature: -----------------------------


                               Holder's Address: -------------------------------


                                                 -------------------------------



Signature Guaranteed: ----------------------------------------------------------



NOTE: The signature to this Assignment Form must correspond with the name as it 
appears on the face of the Warrant, without alteration or enlargement or any 
change whatsoever, and must be guaranteed by a bank or trust company. Officers 
of corporations and those acting in an fiduciary or other representative 
capacity should file proper evidence of authority to assign the foregoing 
Warrant.




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