Securities and Exchange Commission
Washington, DC 20549

Form 10-K

Annual Report Pursuant
to Section 13 or 15(d) of
the Securities Exchange Act of 1934,
For the fiscal year ended December 31, 1999.

Commission file number 1-10706

Comerica Incorporated
Comerica Tower at Detroit Center
500 Woodward Avenue, MC 3391
Detroit, Michigan 48226
1-800-521-1190

Incorporated in the State of Delaware,
IRS Employer Identification No. 38-1998421.

Securities registered pursuant to Section 12(b) of the Act:

- - Common Stock, $5 par value

- - Rights to acquire Series D
Preferred Stock, no par value

- - Preferred Stock Series E, $50.00 liquidation preference per share

These securities are registered on the New York Stock Exchange.

Securities registered pursuant to Section 12(g) of the Act:

- - 9 3/4 percent Subordinated
Notes due 1999

- - 7 1/4 percent Subordinated
Notes due in 2007

The registrant: (1) has filed all reports required to be filed by Section 13 or
15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or
for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days.

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Disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is
contained in the definitive proxy statement incorporated by reference in Part
III of this Form 10-K.

At March 22, 2000, the registrant's common stock, $5 par value, held by
nonaffiliates had an aggregate market value of $6,403,836,447 based on the
closing price on the New York Stock Exchange on that date of $43.00 per share
and 148,926,429 shares of common stock held by nonaffiliates. For purposes of
this Form 10-K only, it has been assumed that all common shares Comerica's Trust
Department holds for Comerica and Comerica's employee plans, and all common
shares the registrant's directors and executive officers hold, are held by
affiliates.

At March 22, 2000, the registrant had outstanding 157,233,088 shares of its
common stock, $5 par value.

DOCUMENTS INCORPORATED
BY REFERENCE:

1. Parts I and II:
Items 1-8--Annual Report to Shareholders for the year ended December 31, 1999.

2. Part III:
Items 10-13--Proxy Statement for the Annual Meeting of Shareholders to be held
May 19, 2000.

PART I

ITEM 1. BUSINESS

GENERAL

Comerica Incorporated ("Comerica" or the "Corporation") is a registered bank
holding company incorporated under the laws of the State of Delaware,
headquartered in Detroit, Michigan. Based on assets as of December 31, 1999, it
was the 24th largest bank holding company in the United States and the largest
bank holding company headquartered in Michigan in terms of both total assets and
total deposits. Comerica was formed in 1973 to acquire the outstanding common
stock of Comerica Bank (formerly Comerica Bank-Detroit), one of Michigan's
oldest banks ("Comerica Bank"). Since that time, Comerica has acquired financial
institutions in California, Texas and Florida, and, in 1998 and 1997, Comerica
formed Comerica Bank-Canada and Comerica Bank-Mexico, S.A., respectively. As of
December 31, 1999, Comerica owned directly or indirectly all the outstanding
common stock of seven banking and thirty-one non-banking subsidiaries. At
December 31, 1999, Comerica had total assets of approximately $38.7 billion,
total deposits of approximately $23.3 billion, total loans (net of unearned
income) of approximately $32.7 billion and common shareholders' equity of
approximately $3.2 billion.

BUSINESS STRATEGY

Comerica has strategically aligned its operations into three major lines of
business: the Business Bank, the Individual Bank and the Investment Bank. The
Business Bank is comprised of middle market lending, asset-based lending, large
corporate banking, treasury management and international

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financial services. This line of business meets the needs of medium-size
businesses, multinational corporations and governmental entities by offering
various products and services, including commercial loans and lines of credit,
deposits, cash management, capital market products, international trade finance,
letters of credit, foreign exchange management services and loan syndication
services.

The Individual Bank includes consumer lending, consumer deposit gathering,
mortgage loan origination and servicing, small business banking (annual sales
under $5 million) and private banking. This line of business offers a variety of
consumer products, including deposit accounts, direct and indirect installment
loans, credit cards, home equity lines of credit and residential mortgage loans.
In addition, a full range of financial services is provided to small businesses
and municipalities. Private lending and personal trust services are also
provided to meet the personal financial needs of affluent individuals (as
defined by individual net income or wealth).

The Investment Bank is responsible for the sale of mutual fund and annuity
products, as well as life, disability and long-term care insurance products.
This line of business also offers institutional trust products, retirement
services and provides investment management and advisory services, investment
banking and discount securities brokerage services.

The core businesses are tailored to each of Comerica's four primary geographic
markets: Michigan, Texas, California and Florida.

In addition to the three major lines of business, the Finance segment is also
significant. The Finance segment includes Comerica's securities portfolio and
asset and liability management activities. This segment is responsible for
managing Comerica's funding, liquidity and capital needs, performing interest
sensitivity gap and earnings simulation analysis and executing various
strategies to manage Comerica's exposure to interest rate risk.

Phase III of Direction 2000

In 1996, Comerica finalized the design of Direction 2000, the strategic effort
to prepare the organization for the new millennium. Following Comerica's 1995
organization of its business units into the Business, Individual and Investment
Banks, and the subsequent alignment and consolidation of back-office areas,
Comerica in 1996 identified which business lines it believed were best managed
on a local basis and a national basis, and realigned its support functions to
optimally link them to business strategies and corporate objectives. In the
third and final phase of this effort, Comerica employees systematically reviewed
all functions of the organization. The full effect of the plan was realized in
fiscal year 1999.

SUPERVISION AND REGULATION

Banks, bank holding companies and financial institutions are highly regulated at
both the state and federal level. As a bank holding company, Comerica is subject
to supervision and regulation by the Federal Reserve Board ("FRB") under the
Bank Holding Company Act of 1956, as amended (the "Act"). Under the Act, the
Corporation historically has been prohibited from engaging in activities other
than those of banking or managing or controlling banks, or from acquiring or
retaining direct or indirect ownership or control of voting shares of any
company which is not a bank or bank holding company or of an entity whose
activities the FRB determines to be so closely related to banking as to be a
proper incident thereto. However, under the Gramm-Leach-Bliley Act of 1999,
effective March 11, 2000,

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this prohibition does not apply if the activities engaged in by the Corporation
or the company whose voting shares are acquired by the Corporation are
activities which, generally, the FRB determines to be financial in nature or
incidental to such financial activity, or complementary to a financial activity
and do not pose a substantial risk to the safety or soundness of depository
institutions or the financial system generally.

Comerica Bank is chartered by the State of Michigan and is supervised and
regulated by the Financial Institutions Bureau of the State of Michigan.
Comerica Bank-Texas is chartered by the State of Texas and is supervised and
regulated by the Texas Department of Banking. Comerica Bank, National
Association and Comerica Bank & Trust, National Association are chartered under
federal law and subject to supervision and regulation by the Office of the
Comptroller of the Currency ("OCC"). Comerica Bank-California is chartered by
the State of California and is supervised and regulated by the California State
Banking Department. Comerica Bank, Comerica Bank & Trust, National Association
and Comerica Bank, National Association are members of the Federal Reserve
System ("FRS"). State member banks are also regulated by the FRB, and state
non-member banks are also regulated by the Federal Deposit Insurance Corporation
("FDIC"). The deposits of all the foregoing banks are insured by the Bank
Insurance Fund ("BIF") of the FDIC to the extent provided by law. Comerica
Bank-Mexico, S.A. is chartered under the laws of Mexico and is supervised and
regulated by the Ministry of Finance and Public Credit, the Bank of Mexico, and
the Mexican National Banking Commission. Comerica Bank-Canada is chartered under
the laws of Ontario, Canada and is supervised and regulated by the Office of the
Superintendent of Financial Institutions Canada and the Canada Deposit Insurance
Corporation.

The FRB supervises non-banking activities conducted by companies Comerica and
Comerica Bank own and the OCC supervises non-banking activities conducted by
companies owned by Comerica Bank & Trust, National Association. In addition,
Comerica's non-banking subsidiaries are subject to supervision and regulation by
various state and federal agencies, including, but not limited to, the National
Association of Securities Dealers, Inc. (in the case of Comerica Securities,
Inc.) the Department of Insurance of the State of Michigan (in the case of
Comerica Insurance, Inc.), and the Securities and Exchange Commission (in the
case of Munder Capital Management).

Set forth below are summaries of selected laws and regulations applicable to
Comerica and its subsidiaries. The summaries are not complete and are qualified
in their entirety by references to the particular statutes and regulations. A
change in applicable law or regulation could have a material effect on the
business of Comerica.

Interstate Banking and Branching

Pursuant to the Riegle-Neal Interstate Banking and Branching Efficiency Act of
1994 (the "Interstate Act"), a bank holding company became able to acquire banks
in states other than its home state, beginning September 29, 1995, without
regard to the permissibility of such acquisition under state law, but subject to
any state requirement that the bank has been organized and operating for a
minimum period of time, not to exceed five years, and the requirement that the
bank holding company, prior to and following the proposed acquisition, control
no more than ten percent of the total amount of deposits of insured depository
institutions in the United States and no more than thirty percent of such
deposits in that state (or such amount as established by state law).

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The Interstate Act also authorizes banks to merge across state lines, thereby
creating interstate branching. All of the states in which Comerica's banking
subsidiaries are located allow interstate branching. Furthermore, under the
Interstate Act, a bank is now able to open new branches in a state in which it
does not already have banking operations if such state enacts a law permitting
such de novo branching.

Since the provision permitting interstate bank acquisitions became effective,
Comerica has had enhanced opportunities to acquire banks in any state subject to
approval by the appropriate federal and state regulatory agencies. Under the
Interstate Act, Comerica has the opportunity to consolidate its affiliate banks
to create one bank with branches in more than one state, or to establish
branches in different states, subject to any state "opt-in" and "opt-out"
provisions.

Financial Modernization

Pursuant to the Gramm-Leach-Bliley Act of 1999, effective March 11, 2000, the
activities in which a bank holding company (each of the deposit institution
subsidiaries of which is well-capitalized and well-managed) may lawfully engage
have been expanded to include insurance underwriting, unlimited securities
underwriting, travel agent services, real estate development, and merchant
banking (the passive investment in equity securities in unlimited amounts).
Comerica is currently studying the advisability of undertaking certain of these
activities.

Dividends

Comerica is a legal entity separate and distinct from its banking and other
subsidiaries. Most of Comerica's revenues result from dividends its bank
subsidiaries pay it. There are statutory and regulatory requirements applicable
to the payment of dividends by subsidiary banks to Comerica as well as by
Comerica to its shareholders. Certain, but not all, of these requirements are
discussed below.

Each state bank subsidiary that is a member of the FRS and each national banking
association is required by federal law to obtain the prior approval of the FRB
or the OCC, as the case may be, for the declaration and payment of dividends, if
the total of all dividends declared by the board of directors of such bank in
any year will exceed the total of (i) such bank's retained net income (as
defined and interpreted by regulation) for that year plus (ii) the retained net
income (as defined and interpreted by regulation) for the preceding two years,
less any required transfers to surplus. Further, federal regulatory agencies can
prohibit a banking institution or bank holding company from engaging in unsafe
and unsound business practices and could prohibit the payment of dividends if
such payment could be deemed an unsafe and unsound banking practice. In
addition, Comerica's state bank subsidiaries that are not members of the FRS are
also subject to limitations under state law regarding the amount of earnings
that may be paid out as dividends.

At January 1, 2000, Comerica's subsidiary banks, without obtaining prior
governmental approvals, could declare aggregate dividends of approximately $879
million from retained net profits of the preceding two years, plus an amount
approximately equal to the net profits (as measured under current regulations),
if any, earned for the period from January 1, 2000 through the date of
declaration. Comerica's subsidiary banks paid dividends of $261 million in 1999,
$442 million in 1998, and $354 million in 1997.

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Source of Strength

According to Federal Reserve Board Policy, bank holding companies are expected
to act as a source of strength to each subsidiary bank and to commit resources
to support each subsidiary bank. This support may be required at times when a
bank holding company may not be able to provide such support. Similarly, under
the cross-guarantee provisions of the Federal Deposit Insurance Act, in the
event of a loss suffered or anticipated by the FDIC (either as a result of the
default of a banking or thrift subsidiary or related to FDIC assistance provided
to a subsidiary in danger of default) one of the other banking subsidiaries may
be assessed for the FDIC's loss, subject to certain exceptions.

FDICIA

FDICIA substantially revised the bank regulatory and funding provisions of the
Federal Deposit Insurance Act and made revisions to several other federal
banking statutes. Among other things, FDICIA requires the federal banking
agencies to take "prompt corrective action" in respect of depository
institutions that do not meet minimum capital requirements. FDICIA establishes
five capital tiers: "well capitalized," "adequately capitalized,"
"undercapitalized," "significantly undercapitalized" and "critically
undercapitalized." A depository institution's capital tier will depend upon
where its capital levels are in relation to various relevant capital measures,
which, among others, include a Tier 1 and total risk-based capital measure and a
leverage ratio capital measure, and certain other factors.

Regulations establishing the specific capital tiers provide that, for an
institution to be well capitalized it must have a total risk-based capital ratio
of at least 10 percent, a Tier 1 risk-based capital ratio of at least 6 percent,
a Tier 1 leverage ratio of at least 5 percent and not be subject to any specific
capital order or directive. For an institution to be adequately capitalized it
must have a total risk-based capital ratio of at least 8 percent, a Tier 1
risk-based capital ratio of at least 4 percent and a Tier 1 leverage ratio of at
least 4 percent (and in some cases 3 percent). Under certain circumstances, the
appropriate banking agency may treat a well capitalized, adequately capitalized
or undercapitalized institution as if the institution were in the next lower
capital category. As of December 31, 1999, each of the banking subsidiaries of
Comerica were well capitalized under these regulations.

FDICIA generally prohibits a depository institution from making any capital
distribution (including payment of a dividend) or paying any management fee to
its holding company if the depository institution would thereafter be
undercapitalized. Undercapitalized depository institutions are subject to
limitations on growth and certain activities and are required to submit an
acceptable capital restoration plan. The federal banking agencies may not accept
a capital plan without determining, among other things, that the plan is based
on realistic assumptions and is likely to succeed in restoring the depository
institution's capital. In addition, for a capital restoration plan to be
acceptable, the depository institution's parent holding company must guarantee
for a specific time period that the institution will comply with such capital
restoration plan. The aggregate liability of the parent holding company under
the guaranty is limited to the lesser of (i) an amount equal to 5 percent of the
depository institution's total assets at the time it became undercapitalized,
and (ii) the amount that is necessary (or would have been necessary) to bring
the institution into compliance with all capital standards applicable with
respect to such institution as of the time it fails to comply with

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the plan. If a depository institution fails to submit or implement an acceptable
plan, it is treated as if it is significantly undercapitalized.

Significantly undercapitalized depository institutions are subject to a number
of requirements and restrictions, including orders to sell sufficient voting
stock to become adequately capitalized, requirements to reduce total assets,
restrictions on interest rates, deposits and asset growth and orders to improve
management cessation of receipt of deposits from correspondent banks. Critically
undercapitalized institutions are subject to the appointment of a receiver or
conservator.

Under FDICIA, the FDIC is permitted to provide financial assistance to an
insured bank before appointment of a conservator or receiver only if (i) such
assistance would be the least costly method of meeting the FDIC's insurance
obligations, (ii) grounds for appointment of a conservator or a receiver exist
or are likely to exist in the future, (iii) it is unlikely that the bank can
meet all capital standards without assistance and (iv) the bank's management has
been competent, has complied with applicable laws, regulations, rules and
supervisory directives and has not engaged in any insider dealing, speculative
practice or other abusive activity.

FDICIA also contains a variety of other provisions that may affect the
operations of depository institutions including new reporting requirements,
regulatory standards for real estate lending, "truth in savings" provisions, the
requirement that a depository institution give 90 days prior notice to customers
and regulatory authorities before closing any branch and a prohibition on the
acceptance or renewal of brokered deposits by depository institutions that are
not well capitalized or are adequately capitalized and have not received a
waiver from the FDIC. Under regulations relating to the brokered deposit
prohibition, Comerica's United States subsidiary banks are all well-capitalized
and may accept brokered deposits without restriction.

FDIC Insurance Assessments

Comerica's subsidiary banks are subject to FDIC deposit insurance assessments.
On January 1, 1994, a risk-based deposit premium assessment system became
effective under which each depository institution is placed in one of nine
assessment categories based on certain capital and supervisory measures. The
deposit insurance assessment schedule published by the FDIC for the assessment
period commencing January 1, 1998, maintained the nine categories but provided
for major reductions in the assessment rates for institutions insured by BIF.
These reductions occurred because the balance in BIF has reached or surpassed
the "designated reserve ratio" set by law for the balance in the fund to
maintain with respect to BIF-insured deposits. The FDIC has continued these
reduced assessment levels.

Enforcement Powers of Federal Banking Agencies

The FRB and other federal banking agencies have broad enforcement powers,
including the power to terminate deposit insurance, impose substantial fines and
other civil and criminal penalties and appoint a conservator or receiver.
Failure to comply with applicable laws, regulations and supervisory agreements
could subject Comerica or its banking subsidiaries, as well as officers and
directors of these organizations, to administrative sanctions and potentially
substantial civil penalties.

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COMPETITION

Banking is a highly competitive business. The Michigan banking subsidiary of the
Corporation competes primarily with Detroit and outstate Michigan banks for
loans, deposits and trust accounts. Through its offices in Arizona, California,
Colorado, Connecticut, Florida, Georgia, Indiana, Illinois, Nevada, Ohio and
Texas, Comerica competes with other financial institutions for various types of
loans. Through its Florida branches, Comerica competes with many companies,
including financial institutions, for trust business.

At year-end 1999, Comerica was the largest bank holding company headquartered in
Michigan in terms of total assets and deposits. Based on the Interstate Act as
described above, the Corporation believes that the level of competition in all
geographic markets will increase in the future. Comerica's banking subsidiaries
also face competition from other financial intermediaries, including savings and
loan associations, consumer finance companies, leasing companies and credit
unions.

EMPLOYEES

As of December 31, 1999, Comerica and its subsidiaries had 8,997 full-time and
1,845 part-time employees.

ITEM 2. PROPERTIES

The executive offices of the Corporation are located in the Comerica Tower at
Detroit Center, 500 Woodward Ave., Detroit, Michigan 48226. Comerica and its
subsidiaries occupy 13 floors of the building, which is leased through Comerica
Bank from an unaffiliated third party. This lease extends through January 2007.
As of December 31, 1999, Comerica Bank operated 290 offices within the States of
Michigan and Florida, of which 180 were owned and 110 were leased. Two other
banking affiliates operate 114 offices in California and Texas. The affiliates
own 50 of their offices and lease 64 offices. Banking affiliates also operate
from leased spaces in Toledo, Ohio; Mexico City, Mexico; and Toronto, Ontario,
Canada.

The Corporation owns an operations and check processing center in Livonia,
Michigan, a ten-story building in the central business district of Detroit that
houses certain departments of the Corporation and Comerica Bank and a building
in Auburn Hills, Michigan, used mainly for consumer lending functions.

In 1983, Comerica entered into a sale/leaseback agreement with an unaffiliated
party covering an operations center which was built in Auburn Hills, Michigan,
and now is occupied by various departments of the Corporation and Comerica Bank.

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ITEM 3. LEGAL PROCEEDINGS

The Corporation and its subsidiaries are parties to litigation and claims
arising in the normal course of their activities. Although the amount of
ultimate liability, if any, with respect to such matters cannot be determined
with reasonable certainty, management, after consultation with legal counsel,
believes that the litigation and claims, some of which are substantial, will not
have a material adverse effect on the Corporation's consolidated financial
position.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

No matters were submitted to shareholders in the fourth quarter of 1999.

PART II

ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS

The common stock of Comerica Incorporated is traded on the New York Stock
Exchange (NYSE Trading Symbol: CMA). At March 22, 2000, there were approximately
17,511 holders of the Corporation's common stock. The stock prices and dividend
information contained in this table have been adjusted to give effect to the
stock split effected in the form of a 50% stock dividend paid on April 1, 1998.

Quarterly cash dividends were declared during 1999 and 1998, totaling $1.44 and
$1.28 per common share per year, respectively. The following table sets forth,
for the periods indicated, the high and low sale prices per share of the
Corporation's common stock as reported on the NYSE Composite Transactions Tape
for all quarters of 1999 and 1998.

- -------------------------------------------------------------------------
Dividend Dividend*
Quarter High Low Per Share Yield
- -------------------------------------------------------------------------

1999

Fourth $61.38 $44.00 $0.36 2.7%

Third 61.63 47.63 0.36 2.6

Second 66.63 57.31 0.36 2.3

First 70.00 58.94 0.36 2.2

1998

Fourth $69.00 $46.50 $0.32 2.2%

Third 71.94 51.00 0.32 2.1

Second 73.00 61.94 0.32 1.9

First 72.13 54.33 0.32 2.0

* Dividend yield is calculated by annualizing the quarterly dividend per share
and dividing by an average of the high and low price in the quarter.

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ITEM 6. SELECTED FINANCIAL DATA

The response to this item is included on page 21 of the Corporation's Annual
Report to Shareholders for the year ended December 31, 1999, which page is
hereby incorporated by reference.

ITEM 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

The response to this item is included under the caption "Financial Review and
Report" on pages 22 through 39 of the Corporation's Annual Report to
Shareholders for the year ended December 31, 1999, which pages are hereby
incorporated by reference.

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

The response to this item is included on pages 34 through 38 of the
Corporation's Annual Report to Shareholders for the year ended December 31,
1999, which pages are hereby incorporated by reference.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The response to this item is included on pages 40 through 68 of the
Corporation's Annual Report to Shareholders for the year ended December 31,
1999, which pages are hereby incorporated by reference.

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
FINANCIAL DISCLOSURE

None.

PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

The response to this item will be included under the sections captioned
"Information About Nominees and Incumbent Directors," "Executive Officers" and
"Section 16(a) Beneficial Ownership Reporting Compliance" of the Corporation's
definitive Proxy Statement relating to the Annual Meeting of Shareholders to be
held on May 19, 2000, which sections are hereby incorporated by reference.

ITEM 11. EXECUTIVE COMPENSATION

The response to this item will be included under the sections captioned
"Compensation of Directors" and "Compensation of Executive Officers" of the
Corporation's definitive Proxy Statement relating to the Annual Meeting of
Shareholders to be held on May 19, 2000, which sections are hereby incorporated
by reference.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The response to this item will be included under the sections captioned
"Security Ownership of Certain Beneficial Owners" and "Security Ownership of
Management" of the Corporation's

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definitive Proxy Statement relating to the Annual Meeting of Shareholders to be
held on May 19, 2000, which sections are hereby incorporated by reference.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

The response to this item will be included under the sections captioned
"Transactions of Directors and Executive Officers with Comerica" and
"Information about Nominees and Incumbent Directors" of the Corporation's
definitive Proxy Statement relating to the Annual Meeting of Shareholders to be
held on May 19, 2000, which sections are hereby incorporated by reference.

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Comerica Incorporated and Subsidiaries
FORM 10-K CROSS-REFERENCE INDEX

Certain information required to be included in this Form 10-K is included in the
1999 Annual Report to Shareholders or in the 2000 Proxy Statement used in
connection with the 2000 annual meeting of share-holders to be held on May 19,
2000.

The following cross-reference index shows the page location in the 1999 Annual
Report or the section of the 2000 Proxy Statement of only that information which
is to be incorporated by reference into this Form 10-K.

All other sections of the 1999 Annual Report or the 2000 Proxy Statement are not
required in this Form 10-K and should not be considered a part thereof.

Page Number of 1999
Annual Report of Section
of 2000 Proxy Statement

PART I

ITEM 1. Business....................................................................................... Included herein
ITEM 2. Properties..................................................................................... Included herein
ITEM 3. Legal Proceedings.............................................................................. Included herein
ITEM 4. Submission of Matters to a Vote of Security Holders -- no matters were
voted upon by security holders in the fourth quarter of 1999.

PART II

ITEM 5. Market for Registrant's Common Equity and Related Security Holder Matters.................... Included herein
ITEM 6. Selected Financial Data................................................................................... 21
ITEM 7. Management's Discussion and Analysis of Financial Condition and Results of Operations ................. 22-39
ITEM 8. Financial Statements and Supplementary Data:
Comerica Incorporated and Subsidiaries
Consolidated Balance Sheets........................................................................... 40
Consolidated Statements of Income.................................................................... 41
Consolidated Statements of Changes in Shareholders' Equity ........................................... 42
Consolidated Statements of Cash Flows................................................................. 43
Notes to Consolidated Financial Statements................................................................ 44
Report of Management...................................................................................... 65
Report of Independent Auditors............................................................................ 65

Statistical Disclosure by Bank Holding Companies:
Analysis of Net Interest Income - Fully Taxable Equivalent............................................... 23
Rate-Volume Analysis - Fully Taxable Equivalent........................................................... 24
Analysis of the Allowance for Credit Losses............................................................... 26
Analysis of Investment Securities and Loans............................................................... 29
Allocation of the Allowance for Credit Losses............................................................. 30
Loan Maturities and Interest Rate Sensitivity............................................................. 30
International Cross-Border Risk........................................................................... 30
Maturity Distribution of Domestic Certificates of Deposit of $100,000 and Over............................ 31
Analysis of Investment Securities Portfolio - Fully Taxable Equivalent.................................... 33
Summary of Nonperforming Assets and Past Due Loans........................................................ 33

ITEM 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure - None.

PART III

ITEM 10. Directors and Executive Officers of the Registrant ... Information About Nominees and Incumbent Directors,
Executive Officers of the Corporation and
Section 16(a) Beneficial Ownership
Reporting Compliance

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ITEM 11. Executive Compensation.......................................................Compensation of Directors and
Compensation of Executive Officers

ITEM 12. Security Ownership of Certain Beneficial Owners and Management..........................Security Ownership
of Certain Beneficial Owners and Security
Ownership of Management

ITEM 13. Certain Relationships and Related Transactions...............................Transactions of Directors and
Executive Officers with Comerica and
Information about Nominees and Incumbent Directors

PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K

(a) The following documents are filed as a part of this report:

1. Financial Statements: The financial statements that are
filed as part of this report are listed under Item 8 in the
Form 10-K Cross-Reference Index on page 12.

2. All of the schedules for which provision is made in the
applicable accounting regulations of the Securities and
Exchange Commission are either not required under the
related instruction, the required information is contained
elsewhere in the Form 10-K, or the schedules are
inapplicable and therefore have been omitted.

Exhibits:

Exhibit Document Number

3.1 Restated Certificate of Incorporation of Comerica
Incorporated, as amended(2)

3.2 Amended and restated bylaws of Comerica Incorporated

4 Rights Agreement between Comerica Incorporated and Comerica
Bank(4)

10.1+ Comerica Incorporated 1997 Long-Term Incentive Plan(2)

10.2+ Comerica Incorporated Management Incentive Plan, 1997(2)

10.3+ Comerica Incorporated Director Fee Deferral Plan(2)

10.4+ Benefit Equalization Plan for Employees of Comerica
Incorporated(2)

10.5+ Comerica Incorporated's Directors Retirement Plan(5)

10.6+ Manufacturers National Corporation's 1987 and 1989 Stock
Option Plans for Key Employees(5)

10.7+ Manufacturers National Corporation's Executive Incentive
Plan(5)

10.8+ Manufacturers National Corporation's Key Employee Retention
Plan(5)

10.9+ Form of Employment Agreement (Exec Off.)(6)

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10.10+ Form of Director Indemnification Agreement between Comerica
Incorporated and its directors(2)

10.11+ Employment Continuation Agreement with Eugene A. Miller(5)

10.12+ Supplemental Pension and Retiree Medical Agreement with
Ralph W. Babb Jr.(7)

10.13+ Employment Agreement with Ralph W. Babb Jr.(7)

10.14+ Comerica Incorporated Deferred Compensation Plan, 1997
Amendment and Restatement(2)

10.15+ Amended and Restated Comerica Incorporated 1997 Long-Term
Incentive Plan, November 19, 1999

10.16+ Amended and Restated Comerica Incorporated Management
Incentive Plan, November 19, 1999

10.17+ Form of Comerica Incorporated Senior Officer Severance Plan
between registrant and listed officers, January 1, 1997(2)

10.18+ 1999 Comerica Incorporated Deferred Compensation Plan,
January 1, 1999

10.19+ 1999 Comerica Incorporated Deferred 3 Year ROE Award Plan,
January 1, 1999

10.20+ Amended and Restated Comerica Incorporated Stock Option Plan
For Non-Employee Directors, January 20, 2000

10.21+ Comerica Incorporated 1999 Discretionary Director Fee
Deferral Plan May 21, 1999

10.22+ Comerica Incorporated 1999 Common Stock Director Fee
Deferral Plan May 21, 1999

11 Statement regarding Computation of Per Share Earnings(8)

13 Registrant's 1999 Annual Report to Shareholders

21 Subsidiaries of Registrant

23 Consent of Ernst & Young LLP

27 1999 Financial Data Schedule (EDGAR version only)

(b) No reports on Form 8-K were filed by the Corporation during the
last quarter of 1999.

(2) Filed as the same exhibit number to Registrant's Annual Report on
Form 10-K for the year ended December 31, 1996, and incorporated
herein by reference.

(4) Incorporated by reference from a report filed by Registrant on Form
8-K dated June 18, 1996, regarding the Registrant's Rights Agreement
with Comerica Bank.

(5) Incorporated by reference from Registrant's Annual Report on Form
10-K for the year ended December 31, 1992 -- Commission File Number
0-7269.

14
15

(6) Incorporated by reference from Registrant's Annual Report on Form
10-K for the year ended December 31, 1997 -- Commission File Number
1-10706.

(7) Incorporated by reference from Registrant's Form 10-Q for the quarter
ended June 30, 1998 -- Commission File Number 1-1076.

(8) Incorporated by reference from Note 12 on page 50 of Registrant's
Annual Report to Shareholders attached hereto as Exhibit 13.
+ Management compensation plan.

15
16

SIGNATURES

Pursuant to the requirements of Section 13 and 15(d) of the Securities Exchange
Act of 1934, the registrant has duly caused this report to be signed on its
behalf by the undersigned thereunto duly authorized in the City of Detroit,
State of Michigan on the 29th day of March, 2000.

COMERICA INCORPORATED

/s/ Eugene A. Miller
- -----------------------------------------------
Eugene A. Miller
Chairman, President and Chief Executive Officer

/s/ Ralph W. Babb Jr.
- -----------------------------------------------
Ralph W. Babb Jr.
Vice Chairman and Chief Financial Officer

/s/ Marvin J. Elenbaas
- -----------------------------------------------
Marvin J. Elenbaas
Senior Vice President and Controller
(Chief Accounting Officer)

Pursuant to the requirements of the Securities Exchange Act of 1934, this report
has been signed by the following persons in the capacities indicated on the
29th day of March, 2000.

BY DIRECTORS

/s/ E. Paul Casey
- -----------------------------------------------
E. Paul Casey

/s/ James F. Cordes
- -----------------------------------------------
James F. Cordes

/s/ J. Philip DiNapoli
- -----------------------------------------------
J. Philip DiNapoli

/s/ Max M. Fisher
- -----------------------------------------------
Max M. Fisher

/s/ John D. Lewis
- -----------------------------------------------
John D. Lewis

16
17

/s/ Wayne B. Lyon
- -----------------------------------------------
Wayne B. Lyon

/s/ Eugene A. Miller
- -----------------------------------------------
Eugene A. Miller

/s/ Alfred A. Piergallini
- -----------------------------------------------
Alfred A. Piergallini

/s/ Howard F. Sims
- -----------------------------------------------
Howard F. Sims

/s/ Martin D. Walker
- -----------------------------------------------
Martin D. Walker

/s/ Patricia M. Wallington
- -----------------------------------------------
Patricia M. Wallington

/s/ Kenneth L. Way
- -----------------------------------------------
Kenneth L. Way

17
18
Exhibit Index
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Exhibit No. Description
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