Exhibit 3.1

                          TARGETED GENETICS CORPORATION

                        AMENDED AND RESTATED ARTICLES OF
                                 INCORPORATION

      Pursuant to RCW 23B.10.070, the following constitutes Amended and Restated
Articles of Incorporation of the undersigned, a Washington corporation. These
Amended and Restated Articles of Incorporation supersede the original Articles
of Incorporation and all amendments thereto.

      These Amended and Restated Articles of Incorporation contain amendments to
the Articles of Incorporation. The date of the adoption of the amendments by the
shareholders of this corporation was May 26, 2005. The date of the adoption of
the amendments by the Board of Directors of this corporation was April 1, 2005.

      The amendments were duly approved by the shareholders of this corporation
in accordance with the provisions of RCW 23B.10.030 and RCW 23B.10.040.

                                 ARTICLE 1. NAME

      The name of this corporation shall be Targeted Genetics Corporation.

                               ARTICLE 2. DURATION

      This corporation is organized under the Washington Business Corporation
Act and shall have perpetual existence.

                          ARTICLE 3. PURPOSE AND POWERS

      The purpose and powers of this corporation are as follows:

      3.1 To engage in the business of biotechnology research and development.

      3.2 To engage in any and all activities that may, in the judgment of the
Board of Directors, at any time be incidental or conducive to the attainment of
the foregoing purpose.

      3.3 To exercise any and all powers that a corporation formed under the
Washington Business Corporation Act, or any amendment thereto or substitute
therefor, may at the time lawfully exercise.

                            ARTICLE 4. CAPITAL STOCK

      4.1 AUTHORIZED CAPITAL

      The total authorized stock of this corporation shall consist of
180,000,000 shares of Common Stock, par value $.01 per share, and 6,000,000
shares of Preferred Stock, par value $.01 per share.

      4.2 ISSUANCE OF PREFERRED STOCK IN SERIES

      The Preferred Stock may be issued from time to time in one or more series,
the shares of each series to have such voting powers, full or limited, and such
designations, preferences and relative, participating, optional or other special
rights and qualifications, limitations or restrictions thereof as are stated and
expressed herein or in the resolution or resolutions providing for the issuance
of such series adopted by the Board of Directors.

            4.2.1 AUTHORITY OF THE BOARD OF DIRECTORS

      Authority is hereby expressly granted to the Board of Directors of this
corporation, subject to the provisions of this Article 4 and to the limitations
prescribed by law, to authorize the issuance of one or more series of Preferred
Stock, and with respect to each such series to fix by resolution or resolutions
providing for the issuance of each series the number of shares of such series,
the voting powers, full or limited, if any, of the shares of such series and the
designations, preferences and relative, participating, optional or other special
rights and the qualifications, limitations or restrictions thereof. The
authority of the Board of Directors with respect to each series of Preferred
Stock shall include, but shall not be limited to, the determination or fixing of
the following:

                  (a) The number of shares of such series;

                  (b) The designation of such series;

                  (c) The dividends of such series, the conditions and dates
upon which such dividends shall be payable, the relation which such dividends
shall bear to the dividends payable on any other class or classes of stock and
whether such dividends shall be cumulative or noncumulative;

                  (d) Whether the shares of such series shall be subject to
redemption by this corporation and, if made subject to such redemption, the
times, prices, rates, adjustments, and other terms and conditions of such
redemption;

                  (e) The terms and amounts of any sinking fund provided for the
purchase or redemption of the shares of such series;

                  (f) Whether or not the shares of such series shall be
convertible into or exchangeable for shares of any other class or classes or of
any other series of any class or classes of stock of this corporation and, if
provision be made for conversion or exchange, the times, prices, rates,
adjustments, and other terms and conditions of such conversion or exchange;

                  (g) The extent, if any, to which the holders of the shares of
such series shall be entitled to vote with respect to the election of directors
or otherwise, including the right to elect a specified number or class of
directors, the number or percentage of votes required for certain actions, and
the extent to which a vote by class or series shall be required for certain
actions;

                  (h) The restrictions, if any, on the issue or reissue of any
Preferred Stock;

                  (i) The rights of the holders of the shares of such series
upon the dissolution of, or upon the distribution of the assets of, this
corporation; and


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                  (j) The extent, if any, to which any committee of the Board of
Directors may fix the designations and any of the preferences or rights of the
shares of such series relating to dividends, redemption, dissolution, any
distribution of assets of this corporation or the conversion into or exchange of
such shares for shares of any other class or classes of stock of this
corporation or any other series of the same or any other class or classes of
stock of this corporation, or fix the number of shares of any such series or
authorize the increase or decrease in the shares of such series.

            4.2.2 DIVIDENDS

      Subject to any preferential rights granted for any series of Preferred
Stock, the holders of shares of the Common Stock shall be entitled to receive
dividends, out of the funds of this corporation legally available therefor, at
the rate and at the time or times, whether cumulative or noncumulative, as may
be provided by the Board of Directors. The holders of shares of the Preferred
Stock shall be entitled to receive dividends to the extent provided herein or by
the Board of Directors in designating the particular series of Preferred Stock.
The holders of shares of the Common Stock shall not be entitled to receive any
dividends thereon other than the dividends referred to in this section.

            4.2.3 VOTING

      The holders of shares of the Common Stock, on the basis of one vote per
share, shall have the right to vote for the election of members of the Board of
Directors of this corporation and the right to vote on all other matters, except
those matters on which a separate class of this corporation's shareholders vote
by class or series to the exclusion of the holders of the shares of the Common
Stock. To the extent provided herein or by resolution or resolutions of the
Board of Directors providing for the issue of a series of Preferred Stock, the
holders of each such series shall have the right to vote for the election of
members of the Board of Directors of this corporation and the right to vote on
all other matters, except those matters in which a separate class of this
corporation's shareholders vote by class or series to the exclusion of the
holders of the shares of such series.

            4.2.4 ISSUANCE OF SHARES

      This corporation may from time to time issue and dispose of any of the
authorized and unissued shares of the Common Stock or the Preferred Stock for
such consideration as may be fixed from time to time by the Board of Directors,
without action by the shareholders. The Board of Directors may provide for
payment therefor to be received by this corporation in cash, property, services
or such other consideration as is approved by the Board of Directors. Any and
all such shares of the Common Stock or the Preferred Stock of this corporation,
the issuance of which has been so authorized, and for which consideration so
fixed by the Board of Directors has been paid or delivered, shall be deemed
fully paid stock and shall not be liable to any further call or assessment
thereon.

      4.3 DESIGNATION OF RIGHTS AND PREFERENCES OF SERIES A PARTICIPATING
          CUMULATIVE PREFERRED STOCK

      The following series of Preferred Stock is hereby designated, which series
shall have the rights, preferences and privileges and limitations set forth
below:


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            4.3.1 DESIGNATION OF SERIES A PARTICIPATING CUMULATIVE PREFERRED
                  STOCK

      The shares of such series shall be designated the "Series A Participating
Cumulative Preferred Stock" (the "Series A Preferred Stock"), par value $.01 per
share. The number of shares initially constituting the Series A Preferred Stock
shall be 800,000; provided, however, if more than a total of 800,000 shares of
Series A Preferred Stock shall be issuable upon the exercise of Rights (the
"Rights") issued pursuant to the Rights Agreement dated as of October 17, 1996
between the corporation and ChaseMellon Shareholder Services, as Rights Agent
(the "Rights Agreement"), the corporation's Board of Directors, pursuant to
Section 23B.06.020 of the Revised Code of Washington, shall direct by resolution
or resolutions that Articles of Amendment be properly executed and filed with
the Washington Secretary of State providing for the total number of shares of
Series A Preferred Stock authorized for issuance to be increased (to the extent
that the Restated Articles of Incorporation then permits) to the largest number
of whole shares (rounded up to the nearest whole number) issuable upon exercise
of such Rights. In addition, such number of shares may be decreased by
resolution of the Board of Directors; provided, however, that no decrease shall
reduce the number of shares of Series A Preferred Stock to a number less than
the number of shares then outstanding plus the number of shares reserved for
issuance upon the exercise of outstanding options, rights or warrants or upon
the conversion of any outstanding securities issued by the corporation
convertible into Series A Preferred Stock.

            4.3.2 DIVIDENDS AND DISTRIBUTIONS

            (a) Subject to the prior and superior rights of the holders of
shares of any other series of Preferred Stock or other class of capital stock of
the corporation ranking prior and superior to the shares of Series A Preferred
Stock with respect to dividends, the holders of shares of Series A Preferred
Stock shall be entitled to receive, when, as, and if declared by the Board of
Directors, out of the assets of the corporation legally available therefor,
quarterly dividends payable in cash on the last day of each fiscal quarter in
each year, or such other dates as the corporation's Board of Directors shall
approve (each such date being referred to in this Designation as a "Quarterly
Dividend Payment Date"), commencing on the first Quarterly Dividend Payment Date
after the first issuance of a share or a fraction of a share of Series A
Preferred Stock, in an amount per share (rounded to the nearest cent) equal to
the greater of (i) $.01 and (ii) the Formula Number (as hereinafter defined)
then in effect times the cash dividends then to be paid on each share of Common
Stock. In addition, if the corporation shall pay any dividend or make any
distribution on the Common Stock payable in assets, securities or other forms of
noncash consideration (other than dividends or distributions solely in shares of
Common Stock), then, in each such case, the corporation shall simultaneously pay
or make on each outstanding whole share of Series A Preferred Stock a dividend
or distribution in like kind equal to the Formula Number then in effect times
such dividend or distribution on each share of Common Stock. As used in this
Designation and in the Rights Agreement, the "Formula Number" shall be 100;
provided, however, that if at any time after October 17, 1996 the corporation
shall (i) declare or pay any dividend on the Common Stock payable in shares of
Common Stock or make any distribution on the Common Stock in shares of Common
Stock, (ii) subdivide (by a stock split or otherwise) the outstanding shares of
Common Stock into a larger number of shares of Common Stock, or (iii) combine
(by a reverse stock split or otherwise) the outstanding shares of Common Stock
into a smaller number of shares of Common Stock, then in each such event the
Formula Number shall be adjusted to a number determined by multiplying the
Formula Number in effect immediately prior to such event by a fraction, the
numerator of which is the number of shares of Common Stock that are outstanding
immediately after such event and the denominator of which is the number of
shares of Common Stock that are


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outstanding immediately prior to such event (and rounding the result to the
nearest whole number); and provided further, that if at any time after October
17, 1996 the corporation shall issue any shares of its capital stock in a
merger, reclassification or change of the outstanding shares of Common Stock,
then in each such event the Formula Number shall be appropriately adjusted to
reflect such merger, reclassification or change so that each share of Preferred
Stock continues to be the economic equivalent of a Formula Number of shares of
Common Stock prior to such merger, reclassification or change.

            (b) The Corporation shall declare a dividend or distribution on the
Series A Preferred Stock as provided in Section 4.3.2(a) immediately prior to or
at the same time it declares a dividend or distribution on the Common Stock
(other than a dividend or distribution solely in shares of Common Stock);
provided, however, that in the event no dividend or distribution (other than a
dividend or distribution in shares of Common Stock) shall have been declared on
the Common Stock during the period between any Quarterly Dividend Payment Date
and the next subsequent Quarterly Dividend Payment Date, a dividend of $.01 per
share on the Series A Preferred Stock shall nevertheless be payable on such
subsequent Quarterly Dividend Payment Date. The Corporation's Board of Directors
may fix a record date for the determination of holders of shares of Series A
Preferred Stock entitled to receive a dividend or distribution declared thereon,
which record date shall be the same as the record date for any corresponding
dividend or distribution on the Common Stock and which shall not be more than 60
days prior to the date fixed for payment thereof.

            (c) Dividends shall begin to accrue and be cumulative on outstanding
shares of Series A Preferred Stock from and after the Quarterly Dividend Payment
Date next preceding the date of original issue of such shares of Series A
Preferred Stock; provided, however, that dividends on such shares that are
originally issued after the record date for the determination of holders of
shares of Series A Preferred Stock entitled to receive a quarterly dividend on
or prior to the next succeeding Quarterly Dividend Payment Date shall begin to
accrue and be cumulative from and after such Quarterly Dividend Payment Date.
Notwithstanding the foregoing, dividends on shares of Series A Preferred Stock
that are originally issued prior to the record date for the determination of
holders of shares of Series A Preferred Stock entitled to receive a quarterly
dividend on or prior to the first Quarterly Dividend Payment Date shall be
calculated as if cumulative from and after the last day of the fiscal quarter
(or such other Quarterly Dividend Payment Date as the corporation's Board of
Directors shall approve) next preceding the date of original issuance of such
shares. Accrued but unpaid dividends shall not bear interest. Dividends paid on
the shares of Series A Preferred Stock in an amount less than the total amount
of such dividends at the time accrued and payable on such shares shall be
allocated pro rata on a share-by-share basis among all such shares at the time
outstanding.

            (d) So long as any shares of Series A Preferred Stock are
outstanding, no dividends or other distributions shall be declared, paid or
distributed, or set aside for payment or distribution, on the Common Stock
unless, in each case, the dividend required by this Section 4.3.2 to be declared
on the Series A Preferred Stock shall have been declared.

            (e) The holders of shares of Series A Preferred Stock shall not be
entitled to receive any dividends or other distributions except as provided in
this Designation.

            4.3.3 VOTING RIGHTS

      The holders of shares of Series A Preferred Stock shall have the following
voting rights:


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            (a) Each holder of Series A Preferred Stock shall be entitled to a
number of votes equal to the Formula Number then in effect for each share of
Series A Preferred Stock held of record on each matter on which holders of the
Common Stock or shareholders generally are entitled to vote, multiplied by the
maximum number of votes per share that any holders of the Common Stock or
shareholders generally then have with respect to such matter (assuming any
holding period or other requirement to vote a greater number of shares is
satisfied).

            (b) Except as otherwise provided in this Designation or by
applicable law, the holders of shares of Series A Preferred Stock and the
holders of shares of Common Stock and any other capital stock of the corporation
having general voting rights shall vote together as one class for the election
of directors of the corporation and on all other matters submitted to a vote of
shareholders of the corporation.

            (c) Except as provided in this Designation or by applicable law,
holders of Series A Preferred Stock shall have no special voting rights and
their consent shall not be required (except to the extent they are entitled to
vote with holders of Common Stock as set forth in this Designation) for
authorizing or taking any corporate action.

                  4.3.4       CERTAIN RESTRICTIONS

                  (a) Whenever quarterly dividends or other dividends or
distributions payable on the Series A Preferred Stock as provided in Section
4.3.2 are in arrears, thereafter and until all accrued and unpaid dividends and
distributions, whether or not declared, on shares of Series A Preferred Stock
outstanding shall have been paid in full, the corporation shall not:

                        (i) declare or pay dividends on, make any other
      distributions on, or redeem or purchase or otherwise acquire for
      consideration any shares of stock ranking junior (either as to dividends
      or upon liquidation, dissolution or winding up) to the Series A Preferred
      Stock;

                        (ii) declare or pay dividends on or make any other
      distributions on any shares of stock ranking on a parity (either as to
      dividends or upon liquidation, dissolution or winding up) with the Series
      A Preferred Stock, except dividends paid ratably on the Series A Preferred
      Stock and all such parity stock on which dividends are payable or in
      arrears in proportion to the total amounts to which the holders of all
      such shares are then entitled;

                        (iii) redeem or purchase or otherwise acquire for
      consideration shares of any stock ranking junior (either as to dividends
      or upon liquidation, dissolution or winding up) with the Series A
      Preferred Stock; provided, however, that the corporation may at any time
      redeem, purchase or otherwise acquire shares of any such junior stock in
      exchange for shares of any stock of the corporation ranking junior (either
      as to dividends or upon dissolution, liquidation or winding up) to the
      Series A Preferred Stock; or

                        (iv) redeem or purchase or otherwise acquire for
      consideration any shares of Series A Preferred Stock, or any shares of
      stock ranking on a parity with the Series A Preferred Stock, except in
      accordance with a purchase offer made in writing or by publication (as
      determined by the corporation's Board of Directors) to all holders of such
      shares upon such terms as the corporation's Board of Directors, after
      consideration of the respective annual dividend rates and other relative
      rights and preferences of the respective


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      series and classes, shall determine in good faith will result in fair and
      equitable treatment among the respective series or classes.

            (b) The corporation shall not permit any subsidiary of the
corporation to purchase or otherwise acquire for consideration any shares of
stock of the corporation unless the corporation could, under paragraph (a) of
this Section 4.3.4, purchase or otherwise acquire such shares at such time and
in such manner.

            4.3.5 LIQUIDATION RIGHTS

                        Upon the liquidation, dissolution or winding up of the
                  corporation, whether voluntary or involuntary, no distribution
                  shall be made to (a) the holders of shares of stock ranking
                  junior (either as to dividends or upon liquidation,
                  dissolution or winding up) to the Series A Preferred Stock
                  unless, prior thereto, the holders of shares of Series A
                  Preferred Stock shall have received an amount equal to the
                  greater of (i) $.01 per share and (ii) the accrued and unpaid
                  dividends and distributions thereon, whether or not declared,
                  to the date of such payment, plus an aggregate amount per
                  share equal to the Formula Number then in effect times the
                  aggregate amount to be distributed per share to holders of
                  Common Stock or (b) the holders of shares of stock ranking on
                  a parity (either as to dividends or upon liquidation,
                  dissolution or winding up) with the Series A Preferred Stock,
                  except distributions made ratably on the Series A Preferred
                  Stock and all other such parity stock in proportion to the
                  total amounts to which the holders of all such shares are
                  entitled upon such liquidation, dissolution or winding up.

            4.3.6 CONSOLIDATION, MERGER, ETC.

                        In case the corporation shall enter into any
                  consolidation, merger, combination or other transaction in
                  which the shares of Common Stock are exchanged for or changed
                  into other stock or securities, cash and/or any other
                  property, then in any such case the then outstanding shares of
                  Series A Preferred Stock shall at the same time be similarly
                  exchanged or changed into an amount per share equal to the
                  Formula Number then in effect times the aggregate amount of
                  stock, securities, cash and/or any other property (payable in
                  kind), as the case may be, into which or for which each share
                  of Common Stock is exchanged or changed. In the event both
                  this Section 4.3.6 and Section 4.3.2 appear to apply to a
                  transaction, this Section 4.3.6 will control.

            4.3.7 NO REDEMPTION; NO SINKING FUND

            (a) The shares of Series A Preferred Stock shall not be subject to
redemption by the corporation or at the option of any holder of Series A
Preferred Stock; provided, however, that the corporation may purchase or
otherwise acquire outstanding shares of Series A Preferred Stock in the open
market or by offer to any holder or holders of shares of Series A Preferred
Stock.

            (b) The shares of Series A Preferred Stock shall not be subject to
or entitled to the operation of a retirement or sinking fund.

            4.3.8 RANKING

                        The Series A Preferred Stock shall rank junior to all
                  other series of Preferred Stock of the corporation, unless the
                  corporation's Board of Directors shall specifically determine
                  otherwise in fixing the powers, preferences and relative,
                  participating, optional and other special rights of the shares
                  of such series and the qualifications, limitations and
                  restrictions thereof.


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            4.3.9 FRACTIONAL SHARES

      The Series A Preferred Stock shall be issuable upon exercise of the Rights
issued pursuant to the Rights Agreement in whole shares or in any fractional
share that is one one-hundredth (1/100th) of a share or any integral multiple of
such fraction, and shall entitle the holder, in proportion to such holder's
fractional shares, to receive dividends, exercise voting rights, participate in
distributions and have the benefit of all other rights of holders of Series A
Preferred Stock. In lieu of fractional shares, the corporation, prior to the
first issuance of a share or a fractional share of Series A Preferred Stock, may
elect to (a) make a cash payment as provided in the Rights Agreement for a
fractional share other than one one-hundredth (1/100th) of a share or any
integral multiple thereof or (b) issue depository receipts evidencing such
authorized fractional share of Series A Preferred Stock pursuant to an
appropriate agreement between the corporation and a depository selected by the
corporation; provided, however, that such agreement shall provide that the
holders of such depository receipts shall have all the rights, privileges and
preferences to which they are entitled as holders of the Series A Preferred
Stock.

            4.3.10 REACQUIRED SHARES

      Any shares of Series A Preferred Stock purchased or otherwise acquired by
the corporation in any manner whatsoever shall be retired and canceled promptly
after the acquisition thereof. All such shares shall upon their cancellation
become authorized but unissued shares of Preferred Stock, without designation as
to series until such shares are once more designated as part of a particular
series by the corporation's Board of Directors pursuant to the provisions of
Article 4 of the Restated Articles of Incorporation.

            4.3.11 AMENDMENT

      None of the powers, preferences and relative, participating, optional and
other special rights of the Series A Preferred Stock as provided in this
Designation or in the Restated Articles of Incorporation shall be amended in any
manner that would alter or change the powers, preferences, rights or privileges
of the holders of Series A Preferred Stock so as to affect them adversely
without the affirmative vote of the holders of at least 66-2/3% of the
outstanding shares of Series A Preferred Stock, voting as a separate class.

                          ARTICLE 5. PREEMPTIVE RIGHTS

      No preemptive rights shall exist with respect to shares of stock or
securities convertible into shares of stock of this corporation.

                          ARTICLE 6. CUMULATIVE VOTING

      The right to cumulate votes in the election of Directors shall not exist
with respect to shares of stock of this corporation.

                                ARTICLE 7. BYLAWS

      The Board of Directors shall have the power to adopt, amend or repeal the
Bylaws of this corporation subject to approval by a majority of the Continuing
Directors (as defined in Article 13); provided, however, the Board of Directors
may not repeal or amend any bylaw that the shareholders have expressly provided
may not be amended or repealed by the Board of Directors. The shareholders shall
also have the power to adopt, amend or repeal the Bylaws of this corporation by


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the affirmative vote of the holders of not less than two-thirds of the
outstanding shares and, to the extent, if any, provided by resolution or
resolutions of the Board of Directors providing for the issuance of a series of
Common or Preferred Stock, not less than two-thirds of the outstanding shares
entitled to vote thereon, voting as a class.

                     ARTICLE 8. REGISTERED OFFICE AND AGENT

      The name of the registered agent of this corporation and the address of
its current registered office are as follows:

                             H. Stewart Parker
                             1100 Olive Way, Suite 100
                             Seattle, Washington  98101

                              ARTICLE 9. DIRECTORS

      The number of Directors of this corporation shall be determined in the
manner provided by the Bylaws and may be increased or decreased from time to
time in the manner provided therein. The Board of Directors shall be divided
into three classes, with such classes to be as equal in number as may be
possible, with any Director or Directors in excess of the number divisible by
three being assigned to Class 3 and Class 2, as appropriate. At each annual
meeting of shareholders, the number of Directors equal to the number of
Directors in the class whose term expires at the time of such meeting shall be
elected to serve until the third ensuing annual meeting of shareholders.
Notwithstanding any of the foregoing provisions of this Article 9, Directors
shall serve until their successors are elected and qualified or until their
earlier death, resignation or removal from office, or until there is a decrease
in the number of Directors.

      The Directors of this corporation may be removed only for cause by the
holders of not less than two-thirds of the shares entitled to elect the Director
or Directors whose removal is sought in the manner provided by the Bylaws.

               ARTICLE 10. AMENDMENTS TO ARTICLES OF INCORPORATION

      This corporation reserves the right to amend or repeal, by the affirmative
vote of the holders of a majority of the outstanding shares and, to the extent,
if any, provided by resolution or resolutions of the Board of Directors
providing for the issuance of a series of Common or Preferred stock, a majority
of the outstanding shares entitled to vote thereon, voting as a class, any of
the provisions contained in these Articles of Incorporation; provided, however,
that amendment or repeal of Article 7, Article 9, Article 10, Article 12 or
Article 13 shall require the affirmative vote of the holders of two-thirds of
the outstanding shares. The rights of the shareholders of this corporation are
granted subject to this reservation; provided, however, that the holders of the
outstanding shares of a class shall be entitled to vote as a class upon a
proposed amendment if the amendment would increase or decrease the aggregate
number of authorized shares of such class, increase or decrease the par value of
the shares of such class, or alter or change the powers, preferences or special
rights of the shares of such class so as to affect them adversely. If any
proposed amendment would alter or change the powers, preferences or special
rights of one or more series of any class so as to affect them adversely, but
shall not affect the entire class, then only the shares of the series so
affected by the amendment shall be considered as a separate class for the
purposes of this Article 10. Notwithstanding the provisions of this Article 10,
the number of authorized shares of any such class or classes of stock may be
increased by the affirmative vote of


                                       9

the holders of a majority of the outstanding shares entitled to vote thereon or
decreased (but not below the number of shares thereof then outstanding) by the
affirmative vote of the holders of a majority of the outstanding shares entitled
to vote thereon, if so provided in any amendment which created such class or
classes of stock or which was adopted prior to the issuance of any shares of
such class or classes of stock, or in any amendment which was authorized by a
resolution or resolutions adopted by the affirmative vote of the holders of a
majority of such class or classes of stock.

                  ARTICLE 11. LIMITATION OF DIRECTOR LIABILITY

      To the full extent that the Washington Business Corporation Act, as it
exists on the date hereof or may hereafter be amended, permits the limitation or
elimination of the liability of Directors, a Director of this corporation shall
not be liable to this corporation or its shareholders for monetary damages for
conduct as a Director. Any amendments to or repeal of this Article 11 shall not
adversely affect any right or protection of a Director of this corporation for
or with respect to any acts or omissions of such Director occurring prior to
such amendment or repeal.

                  ARTICLE 12. SPECIAL MEETINGS OF SHAREHOLDERS

      The Chairman of the Board of Directors, the President or the Board of
Directors may call special meetings of the shareholders for any purpose.
Further, a special meeting of the shareholders shall be held if the holders of
not less than thirty percent (30%) of all the votes entitled to be cast on any
issue proposed to be considered at such special meeting have dated, signed and
delivered to the Secretary one or more written demands for such meeting,
describing the purpose or purposes for which it is to be held.

                     ARTICLE 13. SPECIAL VOTING REQUIREMENTS

      In addition to any affirmative vote required by law, these Articles of
Incorporation or otherwise, any "Business Combination" (as hereinafter defined)
involving this corporation shall be subject to approval in the manner set forth
in this Article 13.

      13.1 DEFINITIONS.

      For the purposes of this Article 13:

      (a) "Business Combination" means (i) a merger, share exchange or
consolidation of this corporation or any of its Subsidiaries with any other
corporation; (ii) the sale, lease, exchange, mortgage, pledge, transfer or other
disposition or encumbrance, whether in one transaction or a series of
transactions, by this corporation or any of its Subsidiaries of all or a
substantial part of the corporation's assets otherwise than in the usual and
regular course of business, or (iii) any agreement, contract or other
arrangement providing for any of the foregoing transactions.

      (b) "Continuing Director" means any member of the Board of Directors who
was a member of the Board of Directors on January 1, 1994 or who is elected to
the Board of Directors after January 1, 1994 upon the recommendation of a
majority of the Continuing Directors voting separately and as a subclass of
Directors on such recommendation.

      (c) "Subsidiary" means a domestic or foreign corporation that has a
majority of its outstanding voting shares owned, directly or indirectly, by this
corporation.


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      13.2 VOTE REQUIRED FOR BUSINESS COMBINATIONS.

      13.2.1 Except as provided in subsection 13.2.2 of this Article 13, the
affirmative vote of not less than two-thirds of the outstanding shares and, to
the extent, if any, provided by resolution or resolutions of the Board of
Directors providing for the issuance of a series of Common or Preferred Stock,
not less than two-thirds of the outstanding shares entitled to vote thereon,
voting as a class, shall be required for the adoption or authorization of a
Business Combination.

      13.2.2 Notwithstanding subsection 13.2.1 of this Article 13, if a Business
Combination shall have been approved by a majority of the Continuing Directors,
voting separately and as a subclass of Directors, and is otherwise required by
law to be approved by this corporation's shareholders, such Business Combination
shall require the affirmative vote of not less than fifty-one percent (51%) of
the outstanding shares entitled to vote thereon and, to the extent, if any,
provided by resolution or resolutions of the Board of Directors providing for
the issuance of a series of Common or Preferred Stock, not less than fifty-one
percent (51%) of the outstanding shares of such series, voting as a class;
provided, however, that if a Business Combination approved by a majority of the
Continuing Directors is not otherwise required by law to be approved by this
corporation's shareholders, then no vote of the shareholders of this corporation
shall be required.

      In addition to any affirmative vote required by law, these Articles of
Incorporation or otherwise, any "Business Combination" (as hereinafter defined)
involving this corporation shall be subject to approval in the manner set forth
in this Article 13.

                SERIES B CONVERTIBLE EXCHANGEABLE PREFERRED STOCK

                      DESIGNATION OF RIGHTS AND PREFERENCES

      There is hereby designated a series of Preferred Stock to be known as
Series B Convertible Exchangeable Preferred Stock (the "Series B Stock"),
consisting of 12,015 shares, $0.01 par value per share, having the following
rights and preferences:

      1. DIVIDEND RIGHTS

      (a) When and if this corporation's Board of Directors shall declare a
dividend or distribution payable with respect to the then-outstanding shares of
Common Stock of this corporation, other than any such dividend or distribution
payable in shares of Common Stock or other securities of this corporation (which
is provided for in Sections 3.3 and 3.4), the holders of the Series B Stock
shall be entitled to the amount of dividends per share that would be payable on
the largest number of whole shares of Common Stock into which a holder's
aggregate shares of Series B Stock could then be converted pursuant to Section
3.1(a) without regard to the provisions of Section 4 (such number to be
determined as of the record date for the determination of holders of Common
Stock entitled to receive such dividend).

      (b) In addition to Section 1(a), subject to the rights of holders, if any,
of shares of Preferred Stock then outstanding having a right to dividends
ranking equal or superior to the rights of holders of Series B Stock, the
holders of the then outstanding Series B Stock shall be entitled to receive, out
of any assets of this corporation legally available therefor, a cumulative
dividend equal to 7.0% per year of $1,000.00 per share (the "Series B Original
Issue Price") (as adjusted for any combinations, consolidations, stock
distributions, stock dividends or other recapitalizations with


                                       11

respect to such shares) plus accrued dividends thereon, compounded on a
semi-annual basis for a period of six years from the date of issuance. Such
dividend shall be payable solely by the issuance of additional shares of Common
Stock upon conversion of the Series B Stock into Common Stock pursuant to
Section 3 hereof; provided, however, that if the Company exercises the
Redemption Right (as defined in Section 4), such dividend shall be payable in
cash upon such redemption in accordance with Section 4. The dividend to be paid
to a holder under this Section 1 upon a conversion of the Series B Stock shall
be equal to that number of shares of Common Stock determined by dividing the
total dividend accrued with respect such holder's Series B Stock by the Series B
Conversion Price, determined in accordance with Section 3 hereof, then in
effect. No dividends shall be payable under this Section 1 in the event the
Exchange Right is exercised pursuant to Section 5.

      (c) In the event of any liquidation, dissolution or winding-up of the
affairs of the Corporation, whether voluntary or involuntary (collectively, a
"Liquidation"), before any payment of cash or distribution of other property
shall be made to the holders of the Common Stock or any other class or series of
stock subordinate in liquidation preference to the Series B Stock, the holders
of the Series B Stock shall be entitled to receive out of the assets of the
Corporation legally available for distribution to its shareholders, the Series B
Original Issue Price (as defined below) per share (as appropriately adjusted for
any combinations or divisions or similar recapitalizations affecting the Series
B Stock after issuance) (the "Series B Liquidation Preference"), out of funds
legally available therefor.

      (d) If, upon any Liquidation, the assets of the Corporation available for
distribution to its shareholders shall be insufficient to pay the holders of the
B Preferred Stock the full amounts to which they shall be entitled, the holders
of the Series B Stock shall share ratably in any distribution of assets in
proportion to the respective amounts which would be payable to them in respect
of the shares held by them if all amounts payable to them in respect of such
were paid in full pursuant to Section 1(c).

      (e) After the distribution described in Section 1(c) above have been paid,
subject to the rights of other series of preferred stock that may from time to
time come into existence, the remaining assets of the Corporation available for
distribution to shareholders shall be distributed among the holders of Common
Stock pro rata based on the number of shares of Common Stock held by each.

      2. VOTING RIGHTS

      Holders of Series B Stock shall not be entitled to vote together with
holders of Common Stock, including with respect to the election of directors of
this corporation, or as a separate class, except as otherwise provided by the
Washington Business Corporation Act (the "WBCA"). To the extent that, under the
WBCA, the vote of the holders of the Series B Stock, voting separately as a
class or series as applicable, is required to authorize a given action of this
corporation, the affirmative vote or consent of the holders of at least a
majority of the shares of the Series B Stock represented at a duly held meeting
at which a quorum is present or by written consent of a majority of the shares
of Series B Stock (except as otherwise may be required under the WBCA) shall
constitute the approval of such action by the class or series. Holders of the
Series B Stock shall be entitled to notice of all shareholder meetings or
written consents (and copies of proxy materials and other information sent to
shareholders) with respect to which they would be entitled as of right under the
WBCA which notice would be provided pursuant to the Company's Bylaws and the
WBCA.


                                       12

      3. CONVERSION

            3.1 RIGHT TO CONVERT; AUTOMATIC CONVERSION

      (a) Subject to Sections 3.3, 3.4, 3.5 and 3.6, each share of Series B
Stock shall be convertible, without payment of any additional consideration by
the holder thereof and at the option of such holder, into such number of fully
paid and nonassessable shares of Common Stock as is determined by dividing the
Series B Original Issue Price, plus any accrued and unpaid dividends, by the
Series B Conversion Price (as defined below) in effect at the time of
conversion, at any time from the date hereof, at the office of this corporation
or any transfer agent for such stock. The Series B Conversion Price shall
initially be $3.32 per share, subject to adjustment as provided below.

      (b) In the event that a Significant Transaction (as defined below) occurs,
then, in such event, the Series B Stock shall automatically be converted into
such number of fully paid and nonassessable shares of Common Stock determined by
dividing the Series B Original Issue Price, plus accrued and unpaid dividends,
by the Series B Conversion Price then in effect, provided that the Corporation
shall have given the holders of the Series B Stock notice that such significant
transaction shall occur. For purposes of this Certificate of Designation,
"Significant Transaction" shall mean (A) a reorganization, merger or
consolidation in which immediately after (by virtue of securities issued as
consideration for such transaction) the former shareholders of this corporation
do not hold at least 50% of the voting power of the surviving or acquiring
entity in approximately the same relative percentage after such acquisition or
sale as before such acquisition or sale, (B) an acquisition of all outstanding
capital stock of this corporation or (C) a sale or other transfer of all or
substantially all of this corporation's assets, but shall not include (1) a
commencement of any bankruptcy or insolvency proceedings, whether voluntary or
involuntary, (2) a filing for reorganization or relief under bankruptcy law, (3)
a consent to the appointment of a receiver, liquidator or trustee for this
corporation or its assets, (4) a making of a general assignment by this
corporation for the benefit of its creditors or (5) any other similar corporate
action.

            3.2 MECHANICS OF CONVERSION

      Before any holder of Series B Stock shall be entitled to convert the same
into shares of Common Stock, such holder shall surrender the certificate or
certificates therefor, duly endorsed, at the office of this corporation or of
any transfer agent for the Series B Stock, and shall give written notice by
mail, postage prepaid, to this corporation at its principal corporate office, of
the election to convert the same and shall state the name or names in which the
certificate or certificates for shares of Common Stock are to be issued. This
corporation shall, as soon as practicable, issue and deliver at such office to
such holder of Series B Stock or to the nominee or nominees of such holder, a
certificate or certificates for the number of shares of Common Stock to which
such holder shall be entitled. Such conversion shall be deemed to have been made
immediately prior to the close of business on the date of such surrender of the
shares of Series B Stock to be converted, and the person or persons entitled to
receive the shares of Common Stock issuable upon such conversion shall be
treated for all purposes as the record holder or holders of such shares of
Common Stock as of such date.

            3.3 CONVERSION PRICE ADJUSTMENTS FOR STOCK SPLITS AND COMBINATIONS

      If this corporation shall at any time or from time to time after the date
that the first share of Series B Stock is issued (the "Original Issue Date")
effect a subdivision of the outstanding Common


                                       13

Stock without a corresponding subdivision of the Series B Stock , the Series B
Conversion Price in effect immediately before that subdivision shall be
proportionately decreased. Conversely, if the Company shall at any time or from
time to time after the Original Issue Date combine the outstanding shares of
Common Stock into a smaller number of shares without a corresponding combination
of the Series B Stock , the Series B Conversion Price in effect immediately
before the combination shall be proportionately increased. Any adjustment under
this Section 3.3 shall become effective at the close of business on the date the
subdivision or combination becomes effective.

            3.4 OTHER DISTRIBUTIONS

      In the event this corporation shall declare a distribution payable in
securities of other persons, evidences of indebtedness issued by this
corporation or other persons, assets (excluding cash dividends) or options or
rights not referred to in Section 3.3, then, in each such case for the purpose
of this Section 3.4, the holders of the Series B Stock shall be entitled to a
proportionate share of any such distribution as though they were the holders of
the number of shares of Common Stock of this corporation into which their shares
of Series B Stock are convertible as of the record date fixed for the
determination of the holders of Common Stock of this corporation entitled to
receive such distribution.

            3.5 RECAPITALIZATIONS

      If the Common Stock issuable upon the conversion of Series B Stock shall
be changed into the same or a different number of shares of any class or classes
of stock of this corporation, whether by capital reorganization,
reclassification or otherwise (other than a subdivision or combination of shares
or stock dividend provided for elsewhere in this Section 3), then and in each
such event each share of Series B Stock shall be convertible into the kind and
amount of shares of stock and other securities and property receivable upon such
reorganization, reclassification or other change by the number of shares of
Common Stock into which such share of Series B Stock might have been converted
immediately prior to such reorganization, reclassification or change, all
subject to further adjustment as provided herein.

            3.6 NO FRACTIONAL SHARES; CERTIFICATES AS TO ADJUSTMENT

      (a) No fractional shares of Common Stock or scrip representing fractional
shares shall be issued upon the conversion of shares of Series B Stock, but this
corporation shall pay to the holder of such shares a cash adjustment in respect
of such fractional shares in an amount equal to the same fraction of the market
price per share of the Common Stock (as determined in a reasonable manner
prescribed by this corporation's Board of Directors) at the close of business on
the applicable conversion date. The determination as to whether or not any
fractional shares are issuable shall be based upon the total number of shares of
Series B Stock being converted at any one time by any holder, not upon each
share of Series B Stock being converted.

      (b) In each case of an adjustment or readjustment of the Series B
Conversion Price, this corporation at its expense will furnish each holder of
Series B Stock with a certificate, signed by this corporation's Chief Financial
Officer, showing such adjustment or readjustment and stating in detail the facts
upon which such adjustment or readjustment is based.


                                       14

            3.7 NOTICES OF RECORD DATE

      In the event of any taking by this corporation of a record of the holders
of any class of securities for the purpose of determining the holders thereof
who are entitled to receive any dividend (other than a cash dividend) or other
distribution, any right to subscribe for, purchase or otherwise acquire any
shares of stock of any class or other securities or property, or to receive any
other right, this corporation shall mail to each holder of Series B Stock, at
least twenty (20) days prior to the date specified therein, a notice specifying
the date on which any such record is to be taken for the purpose of such
dividend, distribution or right, and the amount and character of such dividend,
distribution or right.

            3.8 RESERVATION OF STOCK ISSUABLE UPON CONVERSION

      This corporation shall at all times reserve and keep available out of its
authorized but unissued shares of Common Stock such number of its shares of
Common Stock as shall be sufficient to effect the conversion of all outstanding
shares of the Series B Stock; and if at any time the number of authorized but
unissued shares of Common Stock shall not be sufficient to effect the conversion
of all then outstanding shares of the Series B Stock, in addition to such other
remedies as shall be available to the holder of such Preferred Stock, this
corporation will take such corporate action as may, in the opinion of its
counsel, be necessary to increase its authorized but unissued shares of Common
Stock to such number of shares as shall be sufficient for such purposes.

            3.9 NOTICES

      Any notice required by the provisions of this Section 3 to be given to the
holders of shares of Series B Stock shall be deemed given if deposited in the
United States mail, postage prepaid, and addressed to each holder of record at
such holder's address appearing on the books of this corporation.

      4. LIMITATION ON ISSUANCE OF SHARES UPON CONVERSION; REDEMPTION

      (a) The following definitions shall apply to this Section 4:

            (i)   "Maximum Share Amount" shall mean the number of shares of this
                  corporation's Common Stock equal to 19.99% of this
                  corporation's Common Stock then outstanding;

            (ii)  "Excess Shares" shall mean Common Stock of this corporation
                  which, upon issuance, results in the beneficial ownership (as
                  defined in Rule 13(d)-3 of the Securities Exchange Act of
                  1934) by a holder of shares of Common Stock in excess of the
                  Maximum Share Amount;

            (iii) "Exchange Rules" shall mean the rules or regulations of Nasdaq
                  or any other principal securities market upon which the Common
                  Stock of this corporation is or becomes traded.

      (b) Except as provided in Section 4(c), this corporation shall not be
obligated to issue upon conversion of the Series B Stock, in the aggregate,
Excess Shares if such issuance in excess of the Maximum Shares Amount would
constitute a breach a or violation of the Exchange Rules.


                                       15

      (c) To the extent this corporation will be required, or it appears likely
to the Board of Directors of this corporation that this corporation will be
required, to issue any Excess Shares, this corporation shall promptly use its
best efforts to obtain shareholder approval in accordance with the WBCA, the
applicable rules of the Securities and Exchange Commission and the Exchange
Rules. In the event this corporation does not obtain shareholder approval, this
corporation shall have the right, at its option (the "Redemption Right"), to
redeem, out of funds legally available therefor, all or any part of the Excess
Shares at a redemption price, payable in cash, equal to the Series B Original
Issue Price per share together with accrued and unpaid dividends on any such
shares that are redeemed (the "Redemption Price"). This corporation may exercise
the Redemption Right by providing notice by mail, first class postage prepaid,
to each holder of Series B Stock of record (at the close of business on the
business day preceding the day on which notice is given) of the Series B Stock
to be redeemed, at the address last shown on the records of this corporation for
such holder, notifying such holder of the redemption to be effected, specifying
the number of shares to be redeemed from such holder, the date that the
redemption is to occur (the "Redemption Date"), the place at which payment may
be obtained and calling upon such holder to surrender to this corporation, in
the manner and at the place designated, such holder's certificate or
certificates representing the shares to be redeemed (the "Redemption Notice").
On or after the Redemption Date, each holder of Series B Stock to be redeemed
shall surrender to this corporation the certificate or certificates representing
such shares in the manner and at the place designated in the Redemption Notice,
and thereupon the Redemption Price of such shares shall be payable to the order
of the person whose name appears on such certificate or certificates as the
owner thereof and each surrendered certificate shall be cancelled. In the event
less than all of the shares represented by any such certificate are redeemed, a
new certificate shall be issued representing the unredeemed shares. From and
after the Redemption Date, unless there shall have been a default in payment of
the Redemption Price, all rights of the holders of shares of Series B Stock
designated for redemption in the Redemption Notice as holders of Series B Stock
(except the right to receive the Redemption Price without interest upon
surrender of their certificate or certificates and except as provided in Section
6(c)) shall cease with respect to such shares, and such shares shall not
thereafter be transferred on the books of this corporation or be deemed to be
outstanding for any purpose whatsoever.

      5. EXCHANGE RIGHT

      (a) At any time beginning on the date hereof and ending on the later of
April 21, 2003 or six months after the end of the Research and Development Term
(as defined by the Joint Development and Operating Agreement among this
corporation, Elan Pharmaceuticals, plc, a public liability corporation
incorporated under the laws of Ireland, Elan International Services, Ltd., a
Bermuda corporation ("EIS") and Targeted Genetics Newco, Ltd., a Bermuda
corporation ("Newco")), provided that no shares of Series B Stock representing
the shares initially issued and sold by this corporation to EIS and its
affiliates, together with those issued or issuable in respect of dividends
provided for in Section 1, have been converted as provided in Section 3.1(a) or
3.1(b), the holders of the Series B Stock (by act of the holders of a majority
of the Series B Stock) shall have the right to exchange 100% of such shares of
Series B Stock (the "Exchange Right") with this corporation for 100% of the
outstanding preferred shares of Newco, held by this corporation, representing
30.1% of the beneficial interest in the aggregate issued and outstanding capital
stock of Newco on a fully diluted basis, so that, after giving effect to the
exercise of the Exchange Right, such holders will own such issued and
outstanding capital stock of Newco representing 50.0% of the beneficial interest
in the aggregate issued and outstanding capital stock of Newco on a fully
diluted basis.


                                       16

      (b) In order to exercise the Exchange Right, the holders shall provide
written notice thereof to this corporation, setting forth (i) the fact that such
holders intend to exercise the Exchange Right and (ii) the proposed date for
such exercise (the "Exercise Date"), which shall be between 10 and 30 days after
the date of such notice. On the Exercise Date, (x) the holders shall tender
their shares of Series B Stock to this corporation for cancellation and (y) this
corporation shall cause to be delivered to EIS, acting on behalf of such
holders, such shares of Newco. The holders and this corporation shall take all
other necessary or appropriate actions in connection with or to effect such
closing.

      (c) If any shares of Series B Stock are converted into shares of Common
Stock pursuant to Section 3.1(a) or 3.1(b), the Exchange Right shall terminate
and be of no further force or effect with respect to such shares or with respect
to those shares of Series B Stock issued as dividends pursuant to Section 1. If
all or any shares of the Series B Stock are converted to shares of Common Stock
upon the occurrence of a Significant Transaction, the Exchange Right shall be
preserved for its full term as provided in Section 5(a), except that, to
exercise the Exchange Right, EIS shall be obligated to tender the consideration
received by EIS upon the automatic conversion of the Series B Stock in
connection with such Significant Transaction. If this corporation exercises the
Redemption Right with respect to any shares of Series B Stock, the Exchange
Right shall be preserved for its full term, except that, to exercise the
Exchange Right, in addition to tendering any shares of Series B Stock then
outstanding, EIS shall be obligated to tender the consideration received by EIS
upon the redemption of any Excess Shares in connection with this corporation's
exercise of its Redemption Right.

      6. PROTECTIVE PROVISIONS

      So long as any shares of Series B Stock are outstanding, this corporation
shall not, without first obtaining the approval (by vote or written consent, as
provided by law) of the holders of at least a majority of the then outstanding
shares of Series B Stock, voting as a separate class or series, amend its
Articles of Incorporation so as to adversely affect the rights, preferences or
privileges of the Series B Stock or any holder thereof, including, without
limitation, by creating any series of Preferred Stock (or issuing shares under
any such series) that is senior in right of payment upon liquidation, in respect
of dividends or otherwise to the Series B Stock, or adversely change the rights
of the holders of the Series B Stock in any other respect; provided, however,
that the creation of any series of Preferred Stock (or issuance of shares under
any such series) that is pari passu in respect of dividends or otherwise with
the Series B Stock shall not be deemed to adversely affect the rights,
preferences or privileges of the Series B Stock or any holder thereof or change
the rights of the holders of the Series B Stock in any other respect.

      7. STATUS OF CONVERTED, REDEEMED OR EXCHANGED STOCK

      In the event any shares of Series B Stock shall be converted pursuant to
Section 3, redeemed pursuant to Section 4 or exchanged pursuant to Section 5,
the shares so converted, redeemed or exchanged shall be cancelled and shall not
be reissuable by this corporation.

      Dated: May 27, 2005

                                              TARGETED GENETICS CORPORATION

                                              By:  /S/ H. STEWART PARKER
                                                   ---------------------
                                                   H. Stewart Parker, President
                                                   and Chief Executive Officer


                                       17