EXHIBIT 5.1

                               [HMS&C LETTERHEAD]

                                  July 13, 2005

Rockwell Medical Technologies, Inc.
30142 Wixom Rd.
Wixom, MI 48393

Ladies and Gentlemen:

      We have represented Rockwell Medical Technologies, Inc., a Michigan
corporation (the "Company"), in connection with the preparation and filing with
the Securities and Exchange Commission (the "Commission") of a registration
statement on Form S-8 (the "Registration Statement"), for registration under the
Securities Act of 1933, as amended (the "Securities Act"), of a maximum of
3,416,973 of the Company's Common Shares (the "Common Shares") to be issued
pursuant to options granted under the Rockwell Medical Technologies, Inc. 1997
Stock Option Plan (the "Plan").

      Based upon our examination of such documents and other matters as we deem
relevant, it is our opinion that the Common Shares to be offered by the
Company under the Plan pursuant to the Registration Statement (1) have been duly
authorized and, (2) when issued and sold by the Company in accordance with the
Plan and the stock options granted thereunder, will be legally issued, fully
paid and nonassessable.

      We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement. In giving such consent, we do not admit hereby that we
come within the category of persons whose consent is required under Section 7 of
the Securities Act or the Rules and Regulations of the Commission thereunder.

                                          Very truly yours,

                                          HONIGMAN MILLER SCHWARTZ AND COHN LLP