EXHIBIT 32.2

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the accompanying Quarterly Report of Targeted Genetics
Corporation (the "Company") on Form 10-Q for the period ended September 30, 2005
as filed with the Securities and Exchange Commission on the date hereof (the
"Report"), I, David J. Poston, Acting Chief Financial Officer of the Company,
certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906
of the Sarbanes-Oxley Act of 2002, that:

      (1) The Report fully complies with the requirements of Section 13(a) or
      15(d) of the Securities Exchange Act of 1934, as amended; and

      (2) The information contained in the Report fairly presents, in all
      material respects, the financial condition and results of operations of
      the Company.

Date: November 3, 2005                       /s/ David J. Poston
                                             ----------------------------------
                                              David J. Poston
                                              Acting Chief Financial Officer