EXHIBIT 32.2

  CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350,
      AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the Quarterly Report of Cardiac Science Corporation
(the Company) on Form 10-Q for the quarter ended September 30, 2005 as filed
with the Securities and Exchange Commission on the date hereof (the Report), I,
Michael K. Matysik, Chief Financial Officer of the Company, certify, pursuant to
18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that:

      (1)   The Report fully complies with the requirements of Section 13(a) or
            15(d) of the Securities Exchange Act of 1934; and

      (2)   The information contained in the Report fairly presents, in all
            material respects, the financial condition and result of operations
            of the Company.
                                             /s/ MICHAEL K. MATYSIK
                                             ---------------------------
                                             Michael K. Matysik
                                             Chief Financial Officer

Date: November 9, 2005